1
1 of 2
- Yale Pediatrics1 Long Wharf DriveSte 2nd FloorNew Haven, CT 06511
- Yale MS and Neuroimmunology Center6 Devine StreetSte 2BNorth Haven, CT 06473
Naila Makhani, MD, MPH
Neurology, Pediatric Neurology
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Child
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Board Certified in
Neurology
Biography
Naila Makhani, MD, MPH, created Yale Medicine’s Pediatric Multiple Sclerosis Program to meet the challenges of diagnosing central nervous system diseases in children, who account for up to 10 percent of all cases. She also treats children and adolescents who suffer from central nervous system inflammatory disorders. Dr. Makhani expects new insights into MS to improve the outlook for pediatric patients. “We are starting to learn why MS occurs in children and how they are different from adults with this disease,” she says.
An assistant professor of pediatrics and of neurology at Yale School of Medicine, Dr. Makhani focuses her research on biomarkers for pediatric MS, and is a site investigator for a clinical trial sponsored by Novartis, a Switzerland-based pharmaceutical company. “This is an exciting time for both advances in clinical care and research,” she says. “We have many new treatments for MS that can improve symptoms and long-term outcomes. The number of medications available to children with MS is ever-increasing.”
An advocate for the eradication of MS, Dr. Makhani works closely with the Connecticut chapter of the National MS Society, and is a recipient of a Race to Erase MS Junior Investigator Award.
Titles
- Associate Professor of Pediatrics (Neurology)
- Director, Pediatric MS Program
Education & Training
- FellowshipHospital for Sick Children (2012)
- ResidentHospital for Sick Children (2012)
- MPHHarvard School of Public Health (2011)
- MDUniversity of British Columbia (2005)
- BSSimon Fraser University, Kinesiology (2001)
Additional Information
Honors & Recognitions
- Young Investigator Award: European Congress on Treatment and Research in Multiple Sclerosis (2013)
- William J Logan Award for Excellence in Clinical Teaching: Division of Pediatric Neurology, Hospital for Sick Children (2012)
- American Academy of Neurology Resident Travel Award: (2009)
- Young Investigator Award: World Congress on Treatment and Research in Multiple Sclerosis (2008)
Board Certifications
- Royal College of Physicians & Surgeons of CANADA, Neurology (2010)
Professional Service
- International Pediatric MS Study Group (2012 - Present): Member, Education Committee
- Child Neurology Society (2012 - Present): Member
- American Academy of Neurology (2009 - Present): Member
Publications
- Hayes LH, Hopkins SE, Liu S, Pardo CA, Garcia-Dominguez MA, Oleszek J, Yea C, Ciftci-Kavaklioglu B, Yeh EA, Dean J, Sadowsky CL, Desai J, Wiegand S, Farias-Moeller R, Nash K, Thakur KT, Vargas WS, Hong-Routson SJ, Yeshokumar A, Zhou MS, Makhani N, Wilson-Murphy M, Bove R, Zhang B, Benson LA. Challenges in the Clinical Recognition of Acute Flaccid Myelitis and its Implications. The Journal Of Pediatrics 2022, 253: 55-62.e4. PMID: 36115622, DOI: 10.1016/j.jpeds.2022.09.012.
- Marrie RA, Allegretta M, Barcellos LF, Bebo B, Calabresi PA, Correale J, Davis B, De Jager PL, Gasperi C, Greenbaum C, Helme A, Hemmer B, Kanellis P, Kostich W, Landsman D, Lebrun-Frenay C, Makhani N, Munger KL, Okuda DT, Ontaneda D, Postuma RB, Quandt JA, Roman S, Saidha S, Sormani MP, Strum J, Valentine P, Walton C, Zackowski KM, Zhao Y, Tremlett H. From the prodromal stage of multiple sclerosis to disease prevention. Nature Reviews. Neurology 2022, 18: 559-572. PMID: 35840705, DOI: 10.1038/s41582-022-00686-x.
- Solomon AJ, Arrambide G, Brownlee W, Cross AH, Gaitan MI, Lublin FD, Makhani N, Mowry EM, Reich DS, Rovira À, Weinshenker BG, Cohen JA. Confirming a Historical Diagnosis of Multiple Sclerosis. Neurology Clinical Practice 2022, 12: 263-269. PMID: 35747540, PMCID: PMC9208427, DOI: 10.1212/cpj.0000000000001149.
- Tremlett H, Munger KL, Makhani N. The Multiple Sclerosis Prodrome: Evidence to Action. Frontiers In Neurology 2022, 12: 761408. PMID: 35173664, PMCID: PMC8841819, DOI: 10.3389/fneur.2021.761408.
- Lebrun-Frénay C, Rollot F, Mondot L, Zephir H, Louapre C, Le Page E, Durand-Dubief F, Labauge P, Bensa C, Thouvenot E, Laplaud D, de Seze J, Ciron J, Bourre B, Cabre P, Casez O, Ruet A, Mathey G, Berger E, Moreau T, Al Khedr A, Derache N, Clavelou P, Guennoc AM, Créange A, Neau JP, Tourbah A, Camdessanché JP, Maarouf A, Callier C, Vermersch P, Kantarci O, Siva A, Azevedo C, Makhani N, Cohen M, Pelletier D, Okuda D, Vukusic S, Kantarci O, Siva A, Pelletier D, Okuda D, Azevedo C, Makhani N, Radji F, Morel N, Grosset-Jeannin D, Ungureanu A, Boyer L, Suchet L, Elias Z, Lebrun-Frénay C, Cohen M, Mondot L, Thouvenot E, Ciron J, Durand-Dubief F, Brochet B, Ruet A, Ouallet J, Defer G, Branger P, Derache N, Clavelou P, Taithe F, Alkhedr A, Fromont A, Moreau T, Tourbah A, Casez O, Berger E, Zephir H, Outteryck O, Vermersch P, Hautecoeur P, Androdias G, Ionescu I, Pelletier J, Audoin B, Maarouf A, Ayrignac X, Carra-Dalliere C, Labauge P, Debouverie M, Mathey G, Cabre P, Laplaud D, Wiertlevski S, Bresch S, Castelnovo G, Papeix C, Louapre C, Maillart E, Lubetzki C, Stankoff B, Fontaine B, Giannesini C, Heinzleff O, Créange A, Bourre B, Gout O, Guegen A, Bensa C, Le Page E, Michel L, Magy L, De Seze J, Collongues N, Leray E, Guennoc A, Biotti D, Camdessanché J, De Broucker T, Sehaki S, Devys-Meyer N, Bereau M, Cappe C, Kounkou K, Dumont E, Lescieux E, Protin A, Kane M, Boucher J, Petit J, Tabellah Kasonde I, De Vilmarrest A, Nicol M, Malbezin M, Olaiz J, Rigaud-Bully C, Casey R, Rollot F, Vukusic I, Debard N, Cotton F, Abdelalli A, Di Lelio B, Pinna F, Guillemin F, Ziegler A, Callier C, Zehrouni K, Hodel J, Wahab A, Zedet M, Fagniez O, Laage C, Pottier C, Slesari I, Sampaio M, Neau J, Rabois E, Castex C, Hebant B, Guillaume M, Vimont C, Muraz R, Le Port D, Henry C, Berthe C, Freitas N, Visneux V, Forestier M, Beltran S, Meunier G, Servan J, Pico F, Chatagner V. Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome. JAMA Network Open 2021, 4: e2128271. PMID: 34633424, PMCID: PMC8506228, DOI: 10.1001/jamanetworkopen.2021.28271.
- Makhani N. The multiple sclerosis prodrome is just unspecific symptoms in radiologically isolated syndrome patients – Commentary. Multiple Sclerosis Journal 2021, 27: 1827-1828. PMID: 34494919, PMCID: PMC8740898, DOI: 10.1177/13524585211044951.
- Makhani N, Tremlett H. The multiple sclerosis prodrome. Nature Reviews Neurology 2021, 17: 515-521. PMID: 34155379, PMCID: PMC8324569, DOI: 10.1038/s41582-021-00519-3.
- Murphy O, Messacar K, Benson L, Bove R, Carpenter J, Crawford T, Dean J, DeBiasi R, Desai J, Elrick M, Farias-Moeller R, Gombolay G, Greenberg B, Harmelink M, Hong S, Hopkins S, Oleszek J, Otten C, Sadowsky C, Schreiner T, Thakur K, Van Haren K, Carballo C, Chong P, Fall A, Gowda V, Helfferich J, Kira R, Lim M, Lopez E, Wells E, Yeh E, Pardo C, group A, Salazar-Camelo A, Mithal D, Wilson-Murphy M, Bauer A, Watkins C, Abzug M, Dominguez S, Press C, Yang M, Ahsan N, Ramos-Platt L, Tiongson E, Seruya M, Tilton A, Katz E, Kirschen M, Shah A, Ulloa E, Yum S, Mondok L, Blaufuss M, Rosenfeld A, Vargas W, Zucker J, Yeshokumar A, Navis A, Chao K, Hagen K, Melicosta M, Porter C, Tunney M, Scheuermann R, Duggal P, Pekosz A, Bayliss A, Moore M, Belzberg A, Bembea M, O'Brien C, Riggs R, Nance J, Milstone A, Rice J, Garcia-Dominguez M, Flanagan E, Tillema J, Bosques G, Bhatia S, Gordon-Lipkin E, Deike D, Revivo G, Zlotolow D, deFiebre G, Lazerow P, Lotze T, Bitnun A, Davidge K, Vajsar J, Moore A, Konersman C, Nash K, Strober J, Gupta N, Chiu C, Sweeney M, Jackson W, Simon D, Thakkar K, Cheng J, Luce J, Das S, Vogt M, Vu N, Gofshteyn J, Makhani N, Patel P. Acute flaccid myelitis: cause, diagnosis, and management. The Lancet 2020, 397: 334-346. PMID: 33357469, PMCID: PMC7909727, DOI: 10.1016/s0140-6736(20)32723-9.
- Lebrun‐Frenay C, Kantarci O, Siva A, Sormani M, Pelletier D, Okuda D, Azevedo C, Amato M, Bensa C, Berger E, Brochet B, Ciron J, Cohen M, Inglese M, Keegan B, Labauge P, Laplaud D, Le Page E, Louapre C, Makhani N, Mathey G, Mondot L, Montalban X, Pelletier J, Seze J, deStefano N, Thouvenot E, Tintore M, Tutuncuoglu M, Uygunoglu U, Vermersch P, Weinshenker B, Zeydan B. Radiologically Isolated Syndrome: 10‐Year Risk Estimate of a Clinical Event. Annals Of Neurology 2020, 88: 407-417. PMID: 32500558, DOI: 10.1002/ana.25799.
- Brenton JN, Kammeyer R, Gluck L, Schreiner T, Makhani N. Multiple Sclerosis in Children: Current and Emerging Concepts. Seminars In Neurology 2020, 40: 192-200. PMID: 32294785, PMCID: PMC8514113, DOI: 10.1055/s-0040-1703000.
- Silverman A, Selvadurai C, Picard J, Gluck L, Fisayo A, Makhani N, Benitez V. Clinical Reasoning: A 16-year-old girl with ataxia, oscillopsia, and behavioral changes. Neurology 2020, 94: 10.1212/wnl.0000000000009297. PMID: 32234821, PMCID: PMC7282879, DOI: 10.1212/wnl.0000000000009297.
- Makhani N. Treatment Considerations in the Radiologically Isolated Syndrome. Current Treatment Options In Neurology 2020, 22: 3. PMID: 32009206, DOI: 10.1007/s11940-020-0608-8.
- Makhani N, Lebrun C, Siva A, Narula S, Wassmer E, Brassat D, Brenton JN, Cabre P, Carra Dallière C, de Seze J, Durand Dubief F, Inglese M, Langille M, Mathey G, Neuteboom RF, Pelletier J, Pohl D, Reich DS, Ignacio Rojas J, Shabanova V, Shapiro ED, Stone RT, Tenembaum S, Tintoré M, Uygunoglu U, Vargas W, Venkateswaren S, Vermersch P, Kantarci O, Okuda DT, Pelletier D, . Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome. Multiple Sclerosis Journal - Experimental Translational And Clinical 2019, 5: 2055217319836664. PMID: 30915227, PMCID: PMC6429663, DOI: 10.1177/2055217319836664.
- Aaen G, Waltz M, Vargas W, Makhani N, Ness J, Harris Y, Casper TC, Benson L, Candee M, Chitnis T, Gorman M, Graves J, Greenberg B, Lotze T, Mar S, Tillema JM, Rensel M, Rodriguez M, Rose J, Rubin J, Schreiner T, Waldman A, Weinstock-Guttman B, Belman A, Waubant E, Krupp L. Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis. Journal Of Child Neurology 2018, 34: 148-152. PMID: 30556452, PMCID: PMC6579723, DOI: 10.1177/0883073818815041.
- Messacar K, Sillau S, Hopkins S, Otten C, Wilson-Murphy M, Wong B, Santoro J, Treister A, Tokhie H, Torres A, Zabrocki L, Glanternik J, Hurst A, Martin J, Schreiner T, Makhani N, DeBiasi R, Kruer M, Tremoulet A, Van Haren K, Desai J, Benson L, Gorman M, Abzug M, Tyler K, Dominguez S. 1901. Safety, Tolerability, and Efficacy of Fluoxetine as an Antiviral for Enterovirus D68 Associated Acute Flaccid Myelitis: A Retrospective Multicenter Cohort Study. Open Forum Infectious Diseases 2018, 5: s546-s546. PMCID: PMC6254028, DOI: 10.1093/ofid/ofy210.1557.
- Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology 2018, 92: e2118-e2126. PMID: 30413631, PMCID: PMC6512883, DOI: 10.1212/wnl.0000000000006670.
- Makhani N. The Radiologically Isolated Syndrome: An Opportunity to Prevent Multiple Sclerosis in Children. Pediatric Neurology 2018, 85: 13-15. PMID: 30104110, DOI: 10.1016/j.pediatrneurol.2018.05.009.
- DeStefano K, Makhani N. Radiologically Isolated Syndrome. 2017, 61-65. DOI: 10.1007/978-3-319-61407-6_8.
- Sands T, Kedzierski K, Makhani N. Anti-NMDA Receptor Antibody Encephalitis. 2017, 75-82. DOI: 10.1007/978-3-319-61407-6_10.
- Makhani N, Lebrun C, Siva A, Brassat D, Carra Dallière C, de Seze J, Du W, Durand Dubief F, Kantarci O, Langille M, Narula S, Pelletier J, Rojas JI, Shapiro ED, Stone RT, Tintoré M, Uygunoglu U, Vermersch P, Wassmer E, Okuda DT, Pelletier D. Radiologically isolated syndrome in children. Neurology Neuroimmunology & Neuroinflammation 2017, 4: &na;. PMID: 28959703, PMCID: PMC5614726, DOI: 10.1212/nxi.0000000000000395.
- George I, Makhani N. Genetic and Environmental Risk Factors for Pediatric Multiple Sclerosis. Journal Of Pediatric Neurology 2017, 16: 141-147. DOI: 10.1055/s-0037-1604339.
- Malhotra A, Zhang M, Wu X, Jindal S, Durand D, Makhani N. MRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature. Journal Of Clinical Neuroscience 2017, 39: 63-67. PMID: 28209311, DOI: 10.1016/j.jocn.2016.12.049.
- Makhani N, Mahajan A. Abnormal Fluid-Attenuated Inversion Recovery Signal in the Internal Capsule: A Novel Brain Magnetic Resonance Imaging Finding in a Child With Acute Flaccid Myelitis. Pediatric Neurology 2017, 73: 108-109. PMID: 28262551, DOI: 10.1016/j.pediatrneurol.2017.01.031.
- Makhani N, Brenton J, Banwell B. 100 Acquired Disorders Affecting the White Matter. 2017, 759-766. DOI: 10.1016/b978-0-323-37101-8.00100-4.
- Wassmer E, Chitnis T, Pohl D, Amato MP, Banwell B, Ghezzi A, Hintzen RQ, Krupp LB, Makhani N, Rostásy K, Tardieu M, Tenembaum S, Waldman A, Waubant E, Kornberg AJ. International Pediatric MS Study Group Global Members Symposium report. Neurology 2016, 87: s110-s116. PMID: 27572855, PMCID: PMC10688073, DOI: 10.1212/wnl.0000000000002880.
- Ghezzi A, Amato MP, Makhani N, Shreiner T, Gärtner J, Tenembaum S. Pediatric multiple sclerosis. Neurology 2016, 87: s97-s102. PMID: 27572869, DOI: 10.1212/wnl.0000000000002823.
- Makhani N, Schreiner T. Oral Dimethyl Fumarate in Children With Multiple Sclerosis: A Dual-Center Study. Pediatric Neurology 2016, 57: 101-104. PMID: 26996405, DOI: 10.1016/j.pediatrneurol.2016.01.010.
- George IC, DeStefano K, Makhani N. Radiologically Isolated Syndrome in a Pediatric Patient. Pediatric Neurology 2015, 56: 86-87. PMID: 26724214, DOI: 10.1016/j.pediatrneurol.2015.10.013.
- Makhani N, Banwell B, Tellier R, Yea C, McGovern S, O’Mahony J, Ahorro JM, Arnold D, Sadovnick AD, Marrie RA, Bar-Or A, Network O. Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination. Multiple Sclerosis Journal 2015, 22: 385-388. PMID: 26199356, DOI: 10.1177/1352458515595876.
- Kimball S, Hanwell HE, Burton JM, Heaney RP, Holick MF, Hollis B, Lewanczuk R, Makhani N, Venkateswaran S. Vitamin D supplementation in multiple sclerosis: Making a case for clarity. Journal Of The Neurological Sciences 2014, 347: 391-392. PMID: 25456464, DOI: 10.1016/j.jns.2014.10.003.
- van Pelt ED, Mescheriakova JY, Makhani N, Ketelslegers IA, Neuteboom RF, Kundu S, Broer L, Janssens C, Catsman-Berrevoets CE, van Duijn CM, Banwell B, Bar-Or A, Hintzen RQ. Risk genes associated with pediatric-onset MS but not with monophasic acquired CNS demyelination. Neurology 2013, 81: 1996-2001. PMID: 24198294, DOI: 10.1212/01.wnl.0000436934.40034eb.
- Kingwell E, Marriott JJ, Jetté N, Pringsheim T, Makhani N, Morrow SA, Fisk JD, Evans C, Béland SG, Kulaga S, Dykeman J, Wolfson C, Koch MW, Marrie RA. Incidence and prevalence of multiple sclerosis in Europe: a systematic review. BMC Neurology 2013, 13: 128. PMID: 24070256, PMCID: PMC3856596, DOI: 10.1186/1471-2377-13-128.
- Makhani N, A. Yeh E. Advances in Therapies for Multiple Sclerosis. 2013, 38-68. DOI: 10.2174/9781608057580113010004.
- Makhani N, Morrow SA, Fisk J, Evans C, Beland SG, Kulaga S, Kingwell E, Marriott JJ, Dykeman J, Jetté N, Pringsheim T, Wolfson C, Marrie RA, Koch MW. MS incidence and prevalence in Africa, Asia, Australia and New Zealand: A systematic review. Multiple Sclerosis And Related Disorders 2013, 3: 48-60. PMID: 25877973, DOI: 10.1016/j.msard.2013.06.015.
- Makhani N, Ngan BY, Kamath BM, Yeh EA. Glatiramer acetate–induced acute hepatotoxicity in an adolescent with MS. Neurology 2013, 81: 850-852. PMID: 23884038, PMCID: PMC3908464, DOI: 10.1212/wnl.0b013e3182a2cc4a.
- Evans C, Beland SG, Kulaga S, Wolfson C, Kingwell E, Marriott J, Koch M, Makhani N, Morrow S, Fisk J, Dykeman J, Jetté N, Pringsheim T, Marrie RA. Incidence and Prevalence of Multiple Sclerosis in the Americas: A Systematic Review. Neuroepidemiology 2013, 40: 195-210. PMID: 23363936, DOI: 10.1159/000342779.
- Makhani N, Bigi S, Banwell B, Shroff M. Diagnosing Neuromyelitis Optica. Neuroimaging Clinics Of North America 2013, 23: 279-291. PMID: 23608690, DOI: 10.1016/j.nic.2012.12.007.
- Bigi S, Makhani N, Banwell B. Hiccups, Vomiting and the Brain. Neuropediatrics 2012, 43 DOI: 10.1055/s-0032-1307127.
- Makhani N, Banwell B. Chapter 72 Acquired Disorders Affecting the White Matter. 2012, 1052-1061. DOI: 10.1016/b978-1-4377-0435-8.00072-x.
- Makhani N, Banwell B. Noninfectious Central Nervous System Inflammatory Disorders. Seminars In Pediatric Neurology 2011, 18: 91-94. PMID: 22036488, DOI: 10.1016/j.spen.2011.05.005.
- Makhani N, Banwell B. Environmental Risk Factors for Paediatric Multiple Sclerosis. European Neurological Review 2011, 6: 175. DOI: 10.17925/enr.2011.06.03.175.
- Makhani N, Morris SK, Page AV, Brophy J, Lindsay LR, Banwell BL, Richardson SE. A Twist on Lyme: the Challenge of Diagnosing European Lyme Neuroborreliosis. Journal Of Clinical Microbiology 2010, 49: 455-457. PMID: 21068272, PMCID: PMC3020460, DOI: 10.1128/jcm.01584-10.
- Makhani N, Banwell B. Environmental Risk Factors for Pediatric Multiple Sclerosis. TouchREVIEWS In Neurology 2010, 06: 96. DOI: 10.17925/usn.2010.06.02.96.
- Makhani N, Gorman MP, Branson HM, Stazzone L, Banwell BL, Chitnis T. Cyclophosphamide therapy in pediatric multiple sclerosisSYMBOLSYMBOL. Neurology 2009, 72: 2076-2082. PMID: 19439723, PMCID: PMC2923592, DOI: 10.1212/wnl.0b013e3181a8164c.
- Kiraly SJ, Kiraly MA, Hawe RD, Makhani N. Vitamin D as a Neuroactive Substance: Review. The Scientific World JOURNAL 2006, 6: 125-139. PMID: 16493517, PMCID: PMC5917139, DOI: 10.1100/tsw.2006.25.
- Baross-Francis A, Makhani N, Liskay R, Jirik F. Elevated mutant frequencies and increased C : G→T : A transitions in Mlh1−/− versus Pms2−/− murine small intestinal epithelial cells. Oncogene 2001, 20: 619-625. PMID: 11313994, DOI: 10.1038/sj.onc.1204138.
Locations
1
1 of 2
- Yale Pediatrics1 Long Wharf DriveSte 2nd FloorNew Haven, CT 06511
- Yale MS and Neuroimmunology Center6 Devine StreetSte 2BNorth Haven, CT 06473
Biography
Naila Makhani, MD, MPH, created Yale Medicine’s Pediatric Multiple Sclerosis Program to meet the challenges of diagnosing central nervous system diseases in children, who account for up to 10 percent of all cases. She also treats children and adolescents who suffer from central nervous system inflammatory disorders. Dr. Makhani expects new insights into MS to improve the outlook for pediatric patients. “We are starting to learn why MS occurs in children and how they are different from adults with this disease,” she says.
An assistant professor of pediatrics and of neurology at Yale School of Medicine, Dr. Makhani focuses her research on biomarkers for pediatric MS, and is a site investigator for a clinical trial sponsored by Novartis, a Switzerland-based pharmaceutical company. “This is an exciting time for both advances in clinical care and research,” she says. “We have many new treatments for MS that can improve symptoms and long-term outcomes. The number of medications available to children with MS is ever-increasing.”
An advocate for the eradication of MS, Dr. Makhani works closely with the Connecticut chapter of the National MS Society, and is a recipient of a Race to Erase MS Junior Investigator Award.
Titles
- Associate Professor of Pediatrics (Neurology)
- Director, Pediatric MS Program
Education & Training
- FellowshipHospital for Sick Children (2012)
- ResidentHospital for Sick Children (2012)
- MPHHarvard School of Public Health (2011)
- MDUniversity of British Columbia (2005)
- BSSimon Fraser University, Kinesiology (2001)
Additional Information
Honors & Recognitions
- Young Investigator Award: European Congress on Treatment and Research in Multiple Sclerosis (2013)
- William J Logan Award for Excellence in Clinical Teaching: Division of Pediatric Neurology, Hospital for Sick Children (2012)
- American Academy of Neurology Resident Travel Award: (2009)
- Young Investigator Award: World Congress on Treatment and Research in Multiple Sclerosis (2008)
Board Certifications
- Royal College of Physicians & Surgeons of CANADA, Neurology (2010)
Professional Service
- International Pediatric MS Study Group (2012 - Present): Member, Education Committee
- Child Neurology Society (2012 - Present): Member
- American Academy of Neurology (2009 - Present): Member
Publications
- Hayes LH, Hopkins SE, Liu S, Pardo CA, Garcia-Dominguez MA, Oleszek J, Yea C, Ciftci-Kavaklioglu B, Yeh EA, Dean J, Sadowsky CL, Desai J, Wiegand S, Farias-Moeller R, Nash K, Thakur KT, Vargas WS, Hong-Routson SJ, Yeshokumar A, Zhou MS, Makhani N, Wilson-Murphy M, Bove R, Zhang B, Benson LA. Challenges in the Clinical Recognition of Acute Flaccid Myelitis and its Implications. The Journal Of Pediatrics 2022, 253: 55-62.e4. PMID: 36115622, DOI: 10.1016/j.jpeds.2022.09.012.
- Marrie RA, Allegretta M, Barcellos LF, Bebo B, Calabresi PA, Correale J, Davis B, De Jager PL, Gasperi C, Greenbaum C, Helme A, Hemmer B, Kanellis P, Kostich W, Landsman D, Lebrun-Frenay C, Makhani N, Munger KL, Okuda DT, Ontaneda D, Postuma RB, Quandt JA, Roman S, Saidha S, Sormani MP, Strum J, Valentine P, Walton C, Zackowski KM, Zhao Y, Tremlett H. From the prodromal stage of multiple sclerosis to disease prevention. Nature Reviews. Neurology 2022, 18: 559-572. PMID: 35840705, DOI: 10.1038/s41582-022-00686-x.
- Solomon AJ, Arrambide G, Brownlee W, Cross AH, Gaitan MI, Lublin FD, Makhani N, Mowry EM, Reich DS, Rovira À, Weinshenker BG, Cohen JA. Confirming a Historical Diagnosis of Multiple Sclerosis. Neurology Clinical Practice 2022, 12: 263-269. PMID: 35747540, PMCID: PMC9208427, DOI: 10.1212/cpj.0000000000001149.
- Tremlett H, Munger KL, Makhani N. The Multiple Sclerosis Prodrome: Evidence to Action. Frontiers In Neurology 2022, 12: 761408. PMID: 35173664, PMCID: PMC8841819, DOI: 10.3389/fneur.2021.761408.
- Lebrun-Frénay C, Rollot F, Mondot L, Zephir H, Louapre C, Le Page E, Durand-Dubief F, Labauge P, Bensa C, Thouvenot E, Laplaud D, de Seze J, Ciron J, Bourre B, Cabre P, Casez O, Ruet A, Mathey G, Berger E, Moreau T, Al Khedr A, Derache N, Clavelou P, Guennoc AM, Créange A, Neau JP, Tourbah A, Camdessanché JP, Maarouf A, Callier C, Vermersch P, Kantarci O, Siva A, Azevedo C, Makhani N, Cohen M, Pelletier D, Okuda D, Vukusic S, Kantarci O, Siva A, Pelletier D, Okuda D, Azevedo C, Makhani N, Radji F, Morel N, Grosset-Jeannin D, Ungureanu A, Boyer L, Suchet L, Elias Z, Lebrun-Frénay C, Cohen M, Mondot L, Thouvenot E, Ciron J, Durand-Dubief F, Brochet B, Ruet A, Ouallet J, Defer G, Branger P, Derache N, Clavelou P, Taithe F, Alkhedr A, Fromont A, Moreau T, Tourbah A, Casez O, Berger E, Zephir H, Outteryck O, Vermersch P, Hautecoeur P, Androdias G, Ionescu I, Pelletier J, Audoin B, Maarouf A, Ayrignac X, Carra-Dalliere C, Labauge P, Debouverie M, Mathey G, Cabre P, Laplaud D, Wiertlevski S, Bresch S, Castelnovo G, Papeix C, Louapre C, Maillart E, Lubetzki C, Stankoff B, Fontaine B, Giannesini C, Heinzleff O, Créange A, Bourre B, Gout O, Guegen A, Bensa C, Le Page E, Michel L, Magy L, De Seze J, Collongues N, Leray E, Guennoc A, Biotti D, Camdessanché J, De Broucker T, Sehaki S, Devys-Meyer N, Bereau M, Cappe C, Kounkou K, Dumont E, Lescieux E, Protin A, Kane M, Boucher J, Petit J, Tabellah Kasonde I, De Vilmarrest A, Nicol M, Malbezin M, Olaiz J, Rigaud-Bully C, Casey R, Rollot F, Vukusic I, Debard N, Cotton F, Abdelalli A, Di Lelio B, Pinna F, Guillemin F, Ziegler A, Callier C, Zehrouni K, Hodel J, Wahab A, Zedet M, Fagniez O, Laage C, Pottier C, Slesari I, Sampaio M, Neau J, Rabois E, Castex C, Hebant B, Guillaume M, Vimont C, Muraz R, Le Port D, Henry C, Berthe C, Freitas N, Visneux V, Forestier M, Beltran S, Meunier G, Servan J, Pico F, Chatagner V. Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome. JAMA Network Open 2021, 4: e2128271. PMID: 34633424, PMCID: PMC8506228, DOI: 10.1001/jamanetworkopen.2021.28271.
- Makhani N. The multiple sclerosis prodrome is just unspecific symptoms in radiologically isolated syndrome patients – Commentary. Multiple Sclerosis Journal 2021, 27: 1827-1828. PMID: 34494919, PMCID: PMC8740898, DOI: 10.1177/13524585211044951.
- Makhani N, Tremlett H. The multiple sclerosis prodrome. Nature Reviews Neurology 2021, 17: 515-521. PMID: 34155379, PMCID: PMC8324569, DOI: 10.1038/s41582-021-00519-3.
- Murphy O, Messacar K, Benson L, Bove R, Carpenter J, Crawford T, Dean J, DeBiasi R, Desai J, Elrick M, Farias-Moeller R, Gombolay G, Greenberg B, Harmelink M, Hong S, Hopkins S, Oleszek J, Otten C, Sadowsky C, Schreiner T, Thakur K, Van Haren K, Carballo C, Chong P, Fall A, Gowda V, Helfferich J, Kira R, Lim M, Lopez E, Wells E, Yeh E, Pardo C, group A, Salazar-Camelo A, Mithal D, Wilson-Murphy M, Bauer A, Watkins C, Abzug M, Dominguez S, Press C, Yang M, Ahsan N, Ramos-Platt L, Tiongson E, Seruya M, Tilton A, Katz E, Kirschen M, Shah A, Ulloa E, Yum S, Mondok L, Blaufuss M, Rosenfeld A, Vargas W, Zucker J, Yeshokumar A, Navis A, Chao K, Hagen K, Melicosta M, Porter C, Tunney M, Scheuermann R, Duggal P, Pekosz A, Bayliss A, Moore M, Belzberg A, Bembea M, O'Brien C, Riggs R, Nance J, Milstone A, Rice J, Garcia-Dominguez M, Flanagan E, Tillema J, Bosques G, Bhatia S, Gordon-Lipkin E, Deike D, Revivo G, Zlotolow D, deFiebre G, Lazerow P, Lotze T, Bitnun A, Davidge K, Vajsar J, Moore A, Konersman C, Nash K, Strober J, Gupta N, Chiu C, Sweeney M, Jackson W, Simon D, Thakkar K, Cheng J, Luce J, Das S, Vogt M, Vu N, Gofshteyn J, Makhani N, Patel P. Acute flaccid myelitis: cause, diagnosis, and management. The Lancet 2020, 397: 334-346. PMID: 33357469, PMCID: PMC7909727, DOI: 10.1016/s0140-6736(20)32723-9.
- Lebrun‐Frenay C, Kantarci O, Siva A, Sormani M, Pelletier D, Okuda D, Azevedo C, Amato M, Bensa C, Berger E, Brochet B, Ciron J, Cohen M, Inglese M, Keegan B, Labauge P, Laplaud D, Le Page E, Louapre C, Makhani N, Mathey G, Mondot L, Montalban X, Pelletier J, Seze J, deStefano N, Thouvenot E, Tintore M, Tutuncuoglu M, Uygunoglu U, Vermersch P, Weinshenker B, Zeydan B. Radiologically Isolated Syndrome: 10‐Year Risk Estimate of a Clinical Event. Annals Of Neurology 2020, 88: 407-417. PMID: 32500558, DOI: 10.1002/ana.25799.
- Brenton JN, Kammeyer R, Gluck L, Schreiner T, Makhani N. Multiple Sclerosis in Children: Current and Emerging Concepts. Seminars In Neurology 2020, 40: 192-200. PMID: 32294785, PMCID: PMC8514113, DOI: 10.1055/s-0040-1703000.
- Silverman A, Selvadurai C, Picard J, Gluck L, Fisayo A, Makhani N, Benitez V. Clinical Reasoning: A 16-year-old girl with ataxia, oscillopsia, and behavioral changes. Neurology 2020, 94: 10.1212/wnl.0000000000009297. PMID: 32234821, PMCID: PMC7282879, DOI: 10.1212/wnl.0000000000009297.
- Makhani N. Treatment Considerations in the Radiologically Isolated Syndrome. Current Treatment Options In Neurology 2020, 22: 3. PMID: 32009206, DOI: 10.1007/s11940-020-0608-8.
- Makhani N, Lebrun C, Siva A, Narula S, Wassmer E, Brassat D, Brenton JN, Cabre P, Carra Dallière C, de Seze J, Durand Dubief F, Inglese M, Langille M, Mathey G, Neuteboom RF, Pelletier J, Pohl D, Reich DS, Ignacio Rojas J, Shabanova V, Shapiro ED, Stone RT, Tenembaum S, Tintoré M, Uygunoglu U, Vargas W, Venkateswaren S, Vermersch P, Kantarci O, Okuda DT, Pelletier D, . Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome. Multiple Sclerosis Journal - Experimental Translational And Clinical 2019, 5: 2055217319836664. PMID: 30915227, PMCID: PMC6429663, DOI: 10.1177/2055217319836664.
- Aaen G, Waltz M, Vargas W, Makhani N, Ness J, Harris Y, Casper TC, Benson L, Candee M, Chitnis T, Gorman M, Graves J, Greenberg B, Lotze T, Mar S, Tillema JM, Rensel M, Rodriguez M, Rose J, Rubin J, Schreiner T, Waldman A, Weinstock-Guttman B, Belman A, Waubant E, Krupp L. Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis. Journal Of Child Neurology 2018, 34: 148-152. PMID: 30556452, PMCID: PMC6579723, DOI: 10.1177/0883073818815041.
- Messacar K, Sillau S, Hopkins S, Otten C, Wilson-Murphy M, Wong B, Santoro J, Treister A, Tokhie H, Torres A, Zabrocki L, Glanternik J, Hurst A, Martin J, Schreiner T, Makhani N, DeBiasi R, Kruer M, Tremoulet A, Van Haren K, Desai J, Benson L, Gorman M, Abzug M, Tyler K, Dominguez S. 1901. Safety, Tolerability, and Efficacy of Fluoxetine as an Antiviral for Enterovirus D68 Associated Acute Flaccid Myelitis: A Retrospective Multicenter Cohort Study. Open Forum Infectious Diseases 2018, 5: s546-s546. PMCID: PMC6254028, DOI: 10.1093/ofid/ofy210.1557.
- Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology 2018, 92: e2118-e2126. PMID: 30413631, PMCID: PMC6512883, DOI: 10.1212/wnl.0000000000006670.
- Makhani N. The Radiologically Isolated Syndrome: An Opportunity to Prevent Multiple Sclerosis in Children. Pediatric Neurology 2018, 85: 13-15. PMID: 30104110, DOI: 10.1016/j.pediatrneurol.2018.05.009.
- DeStefano K, Makhani N. Radiologically Isolated Syndrome. 2017, 61-65. DOI: 10.1007/978-3-319-61407-6_8.
- Sands T, Kedzierski K, Makhani N. Anti-NMDA Receptor Antibody Encephalitis. 2017, 75-82. DOI: 10.1007/978-3-319-61407-6_10.
- Makhani N, Lebrun C, Siva A, Brassat D, Carra Dallière C, de Seze J, Du W, Durand Dubief F, Kantarci O, Langille M, Narula S, Pelletier J, Rojas JI, Shapiro ED, Stone RT, Tintoré M, Uygunoglu U, Vermersch P, Wassmer E, Okuda DT, Pelletier D. Radiologically isolated syndrome in children. Neurology Neuroimmunology & Neuroinflammation 2017, 4: &na;. PMID: 28959703, PMCID: PMC5614726, DOI: 10.1212/nxi.0000000000000395.
- George I, Makhani N. Genetic and Environmental Risk Factors for Pediatric Multiple Sclerosis. Journal Of Pediatric Neurology 2017, 16: 141-147. DOI: 10.1055/s-0037-1604339.
- Malhotra A, Zhang M, Wu X, Jindal S, Durand D, Makhani N. MRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature. Journal Of Clinical Neuroscience 2017, 39: 63-67. PMID: 28209311, DOI: 10.1016/j.jocn.2016.12.049.
- Makhani N, Mahajan A. Abnormal Fluid-Attenuated Inversion Recovery Signal in the Internal Capsule: A Novel Brain Magnetic Resonance Imaging Finding in a Child With Acute Flaccid Myelitis. Pediatric Neurology 2017, 73: 108-109. PMID: 28262551, DOI: 10.1016/j.pediatrneurol.2017.01.031.
- Makhani N, Brenton J, Banwell B. 100 Acquired Disorders Affecting the White Matter. 2017, 759-766. DOI: 10.1016/b978-0-323-37101-8.00100-4.
- Wassmer E, Chitnis T, Pohl D, Amato MP, Banwell B, Ghezzi A, Hintzen RQ, Krupp LB, Makhani N, Rostásy K, Tardieu M, Tenembaum S, Waldman A, Waubant E, Kornberg AJ. International Pediatric MS Study Group Global Members Symposium report. Neurology 2016, 87: s110-s116. PMID: 27572855, PMCID: PMC10688073, DOI: 10.1212/wnl.0000000000002880.
- Ghezzi A, Amato MP, Makhani N, Shreiner T, Gärtner J, Tenembaum S. Pediatric multiple sclerosis. Neurology 2016, 87: s97-s102. PMID: 27572869, DOI: 10.1212/wnl.0000000000002823.
- Makhani N, Schreiner T. Oral Dimethyl Fumarate in Children With Multiple Sclerosis: A Dual-Center Study. Pediatric Neurology 2016, 57: 101-104. PMID: 26996405, DOI: 10.1016/j.pediatrneurol.2016.01.010.
- George IC, DeStefano K, Makhani N. Radiologically Isolated Syndrome in a Pediatric Patient. Pediatric Neurology 2015, 56: 86-87. PMID: 26724214, DOI: 10.1016/j.pediatrneurol.2015.10.013.
- Makhani N, Banwell B, Tellier R, Yea C, McGovern S, O’Mahony J, Ahorro JM, Arnold D, Sadovnick AD, Marrie RA, Bar-Or A, Network O. Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination. Multiple Sclerosis Journal 2015, 22: 385-388. PMID: 26199356, DOI: 10.1177/1352458515595876.
- Kimball S, Hanwell HE, Burton JM, Heaney RP, Holick MF, Hollis B, Lewanczuk R, Makhani N, Venkateswaran S. Vitamin D supplementation in multiple sclerosis: Making a case for clarity. Journal Of The Neurological Sciences 2014, 347: 391-392. PMID: 25456464, DOI: 10.1016/j.jns.2014.10.003.
- van Pelt ED, Mescheriakova JY, Makhani N, Ketelslegers IA, Neuteboom RF, Kundu S, Broer L, Janssens C, Catsman-Berrevoets CE, van Duijn CM, Banwell B, Bar-Or A, Hintzen RQ. Risk genes associated with pediatric-onset MS but not with monophasic acquired CNS demyelination. Neurology 2013, 81: 1996-2001. PMID: 24198294, DOI: 10.1212/01.wnl.0000436934.40034eb.
- Kingwell E, Marriott JJ, Jetté N, Pringsheim T, Makhani N, Morrow SA, Fisk JD, Evans C, Béland SG, Kulaga S, Dykeman J, Wolfson C, Koch MW, Marrie RA. Incidence and prevalence of multiple sclerosis in Europe: a systematic review. BMC Neurology 2013, 13: 128. PMID: 24070256, PMCID: PMC3856596, DOI: 10.1186/1471-2377-13-128.
- Makhani N, A. Yeh E. Advances in Therapies for Multiple Sclerosis. 2013, 38-68. DOI: 10.2174/9781608057580113010004.
- Makhani N, Morrow SA, Fisk J, Evans C, Beland SG, Kulaga S, Kingwell E, Marriott JJ, Dykeman J, Jetté N, Pringsheim T, Wolfson C, Marrie RA, Koch MW. MS incidence and prevalence in Africa, Asia, Australia and New Zealand: A systematic review. Multiple Sclerosis And Related Disorders 2013, 3: 48-60. PMID: 25877973, DOI: 10.1016/j.msard.2013.06.015.
- Makhani N, Ngan BY, Kamath BM, Yeh EA. Glatiramer acetate–induced acute hepatotoxicity in an adolescent with MS. Neurology 2013, 81: 850-852. PMID: 23884038, PMCID: PMC3908464, DOI: 10.1212/wnl.0b013e3182a2cc4a.
- Evans C, Beland SG, Kulaga S, Wolfson C, Kingwell E, Marriott J, Koch M, Makhani N, Morrow S, Fisk J, Dykeman J, Jetté N, Pringsheim T, Marrie RA. Incidence and Prevalence of Multiple Sclerosis in the Americas: A Systematic Review. Neuroepidemiology 2013, 40: 195-210. PMID: 23363936, DOI: 10.1159/000342779.
- Makhani N, Bigi S, Banwell B, Shroff M. Diagnosing Neuromyelitis Optica. Neuroimaging Clinics Of North America 2013, 23: 279-291. PMID: 23608690, DOI: 10.1016/j.nic.2012.12.007.
- Bigi S, Makhani N, Banwell B. Hiccups, Vomiting and the Brain. Neuropediatrics 2012, 43 DOI: 10.1055/s-0032-1307127.
- Makhani N, Banwell B. Chapter 72 Acquired Disorders Affecting the White Matter. 2012, 1052-1061. DOI: 10.1016/b978-1-4377-0435-8.00072-x.
- Makhani N, Banwell B. Noninfectious Central Nervous System Inflammatory Disorders. Seminars In Pediatric Neurology 2011, 18: 91-94. PMID: 22036488, DOI: 10.1016/j.spen.2011.05.005.
- Makhani N, Banwell B. Environmental Risk Factors for Paediatric Multiple Sclerosis. European Neurological Review 2011, 6: 175. DOI: 10.17925/enr.2011.06.03.175.
- Makhani N, Morris SK, Page AV, Brophy J, Lindsay LR, Banwell BL, Richardson SE. A Twist on Lyme: the Challenge of Diagnosing European Lyme Neuroborreliosis. Journal Of Clinical Microbiology 2010, 49: 455-457. PMID: 21068272, PMCID: PMC3020460, DOI: 10.1128/jcm.01584-10.
- Makhani N, Banwell B. Environmental Risk Factors for Pediatric Multiple Sclerosis. TouchREVIEWS In Neurology 2010, 06: 96. DOI: 10.17925/usn.2010.06.02.96.
- Makhani N, Gorman MP, Branson HM, Stazzone L, Banwell BL, Chitnis T. Cyclophosphamide therapy in pediatric multiple sclerosisSYMBOLSYMBOL. Neurology 2009, 72: 2076-2082. PMID: 19439723, PMCID: PMC2923592, DOI: 10.1212/wnl.0b013e3181a8164c.
- Kiraly SJ, Kiraly MA, Hawe RD, Makhani N. Vitamin D as a Neuroactive Substance: Review. The Scientific World JOURNAL 2006, 6: 125-139. PMID: 16493517, PMCID: PMC5917139, DOI: 10.1100/tsw.2006.25.
- Baross-Francis A, Makhani N, Liskay R, Jirik F. Elevated mutant frequencies and increased C : G→T : A transitions in Mlh1−/− versus Pms2−/− murine small intestinal epithelial cells. Oncogene 2001, 20: 619-625. PMID: 11313994, DOI: 10.1038/sj.onc.1204138.
Locations
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- Yale Pediatrics1 Long Wharf DriveSte 2nd FloorNew Haven, CT 06511
- Yale MS and Neuroimmunology Center6 Devine StreetSte 2BNorth Haven, CT 06473
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1 of 2
- Yale Pediatrics1 Long Wharf DriveSte 2nd FloorNew Haven, CT 06511
- Yale MS and Neuroimmunology Center6 Devine StreetSte 2BNorth Haven, CT 06473