Nixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neuroscience
Chair, Neurosurgery
Chief, Neurosurgery, Yale New Haven Health System
Chair, Perioperative Executive Leadership Committee
Member, National Academy of Medicine
Co-Director, Yale Program on Neurogenetics

Education & Training

Chief Resident
Yale-New Haven Hospital (1998)
Resident
Yale-New Haven Hospital (1997)
Intern
Yale-New Haven Hospital (1992)
MD
Istanbul University (1991)

Languages Spoken

English
Türkçe (Turkish)

Additional Information

Honors & Recognitions

Publications

P11.46.A Whole exome sequencing identifies novel SLIT2 mutations in primary CNS lymphoma
Kaulen L, Erson-Omay E, Henegariu O, Karschnia P, Huttner A, Günel M, Baehring J. P11.46.A Whole exome sequencing identifies novel SLIT2 mutations in primary CNS lymphoma Neuro-Oncology 2022, 24: ii68-ii68. PMCID: PMC9443199, DOI: 10.1093/neuonc/noac174.235.
Abstract 3312: A CRISPR-Cas9 screen in meningioma reveals GCN2/ATF4 is a novel target that enhances the response to radiation
Baro M, Gunel M, Moliterno J, Contessa J. Abstract 3312: A CRISPR-Cas9 screen in meningioma reveals GCN2/ATF4 is a novel target that enhances the response to radiation Cancer Research 2022, 82: 3312-3312. DOI: 10.1158/1538-7445.am2022-3312.
The quest to unravel the complex genomics of intracranial aneurysms
Barak T, Günel M. The quest to unravel the complex genomics of intracranial aneurysms Nature Cardiovascular Research 2022, 1: 281-282. DOI: 10.1038/s44161-022-00051-7.
Clinical Implications of the Genomic Profiling of Sporadic Multiple Meningiomas
Vetsa S, Vasandani S, Barak T, Yalcin K, Jalal M, Nadar A, Aguilera S, Mishra-Gorur K, Miyagishima D, Marianayanam N, Fulbright R, McGuone D, Günel M, Erson-Omay E, Moliterno J. Clinical Implications of the Genomic Profiling of Sporadic Multiple Meningiomas Journal Of Neurological Surgery Part B Skull Base 2022, 83: s1-s270. DOI: 10.1055/s-0042-1743783.
TRAF7 Mutated Subgroups Differ in Sphenoid Wing Meningiomas with Hyperostosis
Jin L, Vetsa S, Vasandani S, Nadar A, Youngblood M, Gupte T, Barak T, Yalcin K, Aguilera S, Mishra-Gorur K, Blondin N, Gorelick E, Omay S, Pointdujour-Lim R, Judson B, Alperovich M, Aboian M, Marianayagam N, McGuone D, Gunel M, Erson-Omay Z, Fulbright R, Moliterno J. TRAF7 Mutated Subgroups Differ in Sphenoid Wing Meningiomas with Hyperostosis Journal Of Neurological Surgery Part B Skull Base 2022, 83: s1-s270. DOI: 10.1055/s-0042-1743640.
NF2 Mutant Sporadic Meningiomas Differ Based on Location Relative to the Tentorium
Vasandani S, Vetsa S, Jalal M, Kanat Y, Marianayagam N, Jin L, Fulbright R, Erson-Omay E, Gunel M, Moliterno J. NF2 Mutant Sporadic Meningiomas Differ Based on Location Relative to the Tentorium Journal Of Neurological Surgery Part B Skull Base 2022, 83: s1-s270. DOI: 10.1055/s-0042-1743734.
Abstract 105: Polygenic Burden Of Hypertension-related Alleles Leads To Non-traumatic Subarachnoid Hemorrhage At Younger Ages
Vanent K, Acosta J, Both C, Leasure A, Noche R, Levitt M, Matouk C, Gunel M, Sheth K, Falcone G. Abstract 105: Polygenic Burden Of Hypertension-related Alleles Leads To Non-traumatic Subarachnoid Hemorrhage At Younger Ages Stroke 2022, 53: a105-a105. DOI: 10.1161/str.53.suppl_1.105.
EPCO-29. GENOMIC PROFILING OF SPORADIC MULTIPLE MENINGIOMAS
Erson-Omay Z, Barak T, Vetsa S, Nadar A, Miyagishima D, Yalcin K, Aguilera S, Mishra-Gorur K, McGuone D, Fulbright R, Gunel M, Moliterno-Gunel J. EPCO-29. GENOMIC PROFILING OF SPORADIC MULTIPLE MENINGIOMAS Neuro-Oncology 2021, 23: vi8-vi8. DOI: 10.1093/neuonc/noab196.028.
INNV-09. SURGICAL STRATEGIES FOR OLDER PATIENTS WITH GLIOBLASTOMA
Barak T, Hwang L, Chen J, Jin L, Miyagishima D, Yalcin K, Ogilvie S, Antonios J, Theriault B, Huttner A, McGuone D, Lifton N, Blondin N, Corbin Z, Zhang Y, Gunel M, Erson-Omay Z, Fulbright R, Tabar T, Moliterno-Gunel J. INNV-09. SURGICAL STRATEGIES FOR OLDER PATIENTS WITH GLIOBLASTOMA Neuro-Oncology 2021, 23: vi107-vi107. PMCID: PMC8598632, DOI: 10.1093/neuonc/noab196.421.
NIMG-64. TYPE OF BONY INVOLVEMENT PREDICTS GENOMIC SUBGROUP IN SPHENOID WING MENINGIOMAS
Jin L, Youngblood M, Gupte T, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera S, Mishra-Gorur K, Blondin N, Omay S, Pointdujour-Lim R, Judson B, Alperovich M, Aboian M, McGuone D, Gunel M, Erson-Omay Z, Fulbright R, Moliterno J. NIMG-64. TYPE OF BONY INVOLVEMENT PREDICTS GENOMIC SUBGROUP IN SPHENOID WING MENINGIOMAS Neuro-Oncology 2021, 23: vi144-vi144. PMCID: PMC8598770, DOI: 10.1093/neuonc/noab196.562.
Abstract P412: Klotho -vS Heterozygosity is Associated With Lower Risk of Non-Traumatic Subarachnoid Hemorrhage
Acosta J, Szejko N, Torres Lopez V, Both C, Sansing L, Sheth K, Matouk C, Gunel M, Falcone G. Abstract P412: Klotho -vS Heterozygosity is Associated With Lower Risk of Non-Traumatic Subarachnoid Hemorrhage Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p412.
The Genomic Landscape of Meningiomas
Zhao A, Youngblood M, Erson-Omay E, Moliterno J, Gunel M. The Genomic Landscape of Meningiomas 2020, 35-55. DOI: 10.1007/978-3-030-59558-6_4.
Clinical and Genomic Factors Associated With Seizures in Meningiomas
Gupte T, Jin L, Li C, Yalcin K, Youngblood M, Miyagishima D, Gorur K, Zhao A, Fulbright R, Omay Z, Gunel M, Moliterno Gunel J. Clinical and Genomic Factors Associated With Seizures in Meningiomas Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_796.
NCOG-50. CLINICAL AND GENOMIC FACTORS ASSOCIATED WITH SEIZURES IN MENINGIOMAS
Gupte T, Jin L, Li C, Yalcin K, Youngblood M, Miyagishima D, Mishra K, Fulbright R, Erson-omay Z, Gunel M, Moliterno J. NCOG-50. CLINICAL AND GENOMIC FACTORS ASSOCIATED WITH SEIZURES IN MENINGIOMAS Neuro-Oncology 2020, 22: ii140-ii140. PMCID: PMC7651386, DOI: 10.1093/neuonc/noaa215.588.
PATH-39. ASSOCIATIONS OF GENOMIC SUBGROUP WITH RECURRENCE IN LOW-GRADE MENINGIOMAS
Youngblood M, Miyagishima D, Jin L, Gupte T, Li C, Duran D, Montejo J, Zhao A, Sheth A, Tyrtova E, Özduman K, Iacoangeli F, Peyre M, Boetto J, Pease M, Avşar T, Huttner A, Bilguvar K, Kilic T, Pamir M, Amankulor N, Kalamarides M, Erson-omay Z, Gunel M, Moliterno J. PATH-39. ASSOCIATIONS OF GENOMIC SUBGROUP WITH RECURRENCE IN LOW-GRADE MENINGIOMAS Neuro-Oncology 2020, 22: ii172-ii173. PMCID: PMC7651600, DOI: 10.1093/neuonc/noaa215.720.
Micro-RNA Mutations Across Multiple Resections of a Giant Nonfunctional Pituitary Adenoma
Gummadavelli A, McCarthy L, Erson Z, Vining E, Gunel M, Omay S. Micro-RNA Mutations Across Multiple Resections of a Giant Nonfunctional Pituitary Adenoma Journal Of Neurological Surgery Part B Skull Base 2020, 81: s1-s272. DOI: 10.1055/s-0040-1702680.
Abstract 66: Causal Associations Between Genetically-determined Smoking and Risk of Subarachnoid Hemorrhage
Acosta J, Both C, Brown S, Leasure A, Vanent K, Noche R, Kirsch E, Petersen N, Matouk C, Gunel M, Gill T, Sheth K, Falcone G. Abstract 66: Causal Associations Between Genetically-determined Smoking and Risk of Subarachnoid Hemorrhage Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.66.
Abstract 71: Sex and Genetic Predisposition Synergistically Influence Risk of Stroke and Myocardial Infarction in Middle-Aged Persons Without Risk Factors
Falcone G, Acosta J, Leasure A, Vanent K, Noche R, Kirsch E, Petersen N, Schindler J, Sansing L, Gill T, Matouk C, Gunel M, Sheth K. Abstract 71: Sex and Genetic Predisposition Synergistically Influence Risk of Stroke and Myocardial Infarction in Middle-Aged Persons Without Risk Factors Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.71.
GENE-56. MENINGIOMA GENOMIC SUBGROUP AS A PREDICTOR OF POST-OPERATIVE PATIENT OUTCOMES: IMPLICATIONS FOR TREATMENT AND FOLLOW-UP
Youngblood M, Sheth A, Zhao A, Montejo J, Duran D, Li C, Tyrtova E, Özduman K, Peyre M, Boetto J, Omay S, Kalamarides M, Zeynep Erson-Omay E, Günel M, Moliterno J. GENE-56. MENINGIOMA GENOMIC SUBGROUP AS A PREDICTOR OF POST-OPERATIVE PATIENT OUTCOMES: IMPLICATIONS FOR TREATMENT AND FOLLOW-UP Neuro-Oncology 2019, 21: vi109-vi110. PMCID: PMC6846980, DOI: 10.1093/neuonc/noz175.458.
Identification of Peptidyl-Prolyl Cis-Trans Isomerase-Like 4 as a Disease Causing Gene in Intracranial Aneurysms and its Role in Vertebrate CNS Specific Angiogenesis
Barak T, Sencicek A, Miyagishima D, Henegariu O, Gorur K, Bilguvar K, Gunel M. Identification of Peptidyl-Prolyl Cis-Trans Isomerase-Like 4 as a Disease Causing Gene in Intracranial Aneurysms and its Role in Vertebrate CNS Specific Angiogenesis Neurosurgery 2019, 66: 310-303. DOI: 10.1093/neuros/nyz310_303.
Outcome Analysis Among Meningioma Genomic Subgroups Identifies Decreased Recurrence Free Survival in PI3K Activated Tumors
Youngblood M, Sheth A, Zhao A, Montejo J, Duran D, Li C, Tyrtova E, Ozduman K, Miyagishima D, Boetto J, Peyre M, Omay S, Kalamarides M, Omay Z, Gunel M, Moliterno J. Outcome Analysis Among Meningioma Genomic Subgroups Identifies Decreased Recurrence Free Survival in PI3K Activated Tumors Neurosurgery 2019, 66: 310-646. DOI: 10.1093/neuros/nyz310_646.
Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis
Timberlake AT, Jin SC, Nelson-Williams C, Wu R, Furey CG, Islam B, Haider S, Loring E, Galm A, Steinbacher D, Larysz D, Staffenberg D, Flores R, Rodriguez E, Boggon T, Persing J, Lifton R, Lifton RP, Gunel M, Mane S, Bilguvar K, Gerstein M, Loring E, Nelson-Williams C, Lopez F, Knight J. Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 15116-15121. PMID: 31292255, PMCID: PMC6660739, DOI: 10.1073/pnas.1902041116.
P04.60 Genomic profile of tumorigenesis in a patient with Turcot syndrome
Karschnia P, Erson-Omay E, Huttner A, Fulbright R, Günel M, Baehring J. P04.60 Genomic profile of tumorigenesis in a patient with Turcot syndrome Neuro-Oncology 2018, 20: iii293-iii293. PMCID: PMC6143975, DOI: 10.1093/neuonc/noy139.294.
116 Exome Sequencing Uncovers Molecular Determinants of Trigeminal Neuralgia
Choi J, Zeng X, Jin S, Gaillard J, Duran D, Nelson-Williams C, Panchagnula S, Dib-Hajj S, Barker F, Sekula R, Waxman S, Gunel M, Lifton R, T. K. 116 Exome Sequencing Uncovers Molecular Determinants of Trigeminal Neuralgia Neurosurgery 2018, 65: 85-86. DOI: 10.1093/neuros/nyy303.116.
141 Meningioma With Multiple Drivers
Tyrtova E, Li C, Youngblood M, Duran D, Montejo J, Coskun S, Miyagishima D, Bilguvar K, Gunel M. 141 Meningioma With Multiple Drivers Neurosurgery 2018, 65: 94. DOI: 10.1093/neuros/nyy303.141.
9p24 triplication in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus
Furey C, Antwi P, Duran D, Timberlake AT, Nelson-Williams C, Matouk CC, DiLuna ML, Günel M, Kahle KT. 9p24 triplication in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus Molecular Case Studies 2018, 4: a003145. PMID: 29895553, PMCID: PMC6169828, DOI: 10.1101/mcs.a003145.
Predictors of Vessel Wall Enhancement in Unruptured Intracranial Aneurysms
Sommaruga S, Cord B, Santarosa C, Malhotra A, Jonhson M, Sheth K, Gunel M, Herbert R, Bijlenga P, Schaller K, Falcone G, Matouk C. Predictors of Vessel Wall Enhancement in Unruptured Intracranial Aneurysms Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660769.
Abstract WMP31: Vessel Wall Enhancement is Associated With Clinical and Imaging Markers of Aneurysm Instability
Sommaruga S, Cord B, Molhotra A, Johnson M, Minja F, Gunel M, Sheth K, Herbert R, Melnikov F, Schaller K, Mandell D, Bijlenga P, Falcone G, Matouk C. Abstract WMP31: Vessel Wall Enhancement is Associated With Clinical and Imaging Markers of Aneurysm Instability Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wmp31.
Production of 2-Hydroxyglutarate by IDH Mutant Malignancies Induces a BRCAness State That Can be Exploited By PARP Inhibitors and Radiation
Corso C, Bindra R, Glazer P, Sulkowski P, Robinson N, Scanlon S, Purshouse K, Bai H, Liu Y, Sundaram R, Hegan D, Fons N, Breuer G, Song Y, Mishra-Gorur K, De Feyter H, de Graaf R, Surovtseva Y, Kachman M, Halene S, Gunel M. Production of 2-Hydroxyglutarate by IDH Mutant Malignancies Induces a BRCAness State That Can be Exploited By PARP Inhibitors and Radiation International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e68. DOI: 10.1016/j.ijrobp.2017.06.754.
102 Exome Sequencing Identifies Novel Molecular Determinants of Human Congenital Hydrocephalus
Furey C, Choi J, Duran D, Timberlake A, Zeng X, Nelson-Williams C, Khanna A, Iskandar B, Butler W, Heuer G, Bayri Y, Sahin Y, Limbrick D, Warf B, Duncan C, DiLuna M, Gunel M, Lifton R, Kahle K. 102 Exome Sequencing Identifies Novel Molecular Determinants of Human Congenital Hydrocephalus Neurosurgery 2017, 64: 220. DOI: 10.1093/neuros/nyx417.102.
168 Wall Enhancement in Unruptured Aneurysms is Associated with Symptomatic Presentation and Size
Cord B, Sommaruga S, Hebert R, Malhotra A, Johnson M, Minja F, Gunel M, Sheth K, Falcone G, Matouk C. 168 Wall Enhancement in Unruptured Aneurysms is Associated with Symptomatic Presentation and Size Neurosurgery 2017, 64: 243. DOI: 10.1093/neuros/nyx417.168.
Personalized Medicine Through Advanced Genomics
Youngblood M, Erson-Omay E, Günel M. Personalized Medicine Through Advanced Genomics 2016, 31-48. DOI: 10.1007/978-3-319-49864-5_3.
GENO-15IDENTIFICATION AND GENOMIC ANALYSIS OF HYPER-MUTATED AND ULTRA-MUTATED GBMS
Erson-Omay E, Schultz N, Omay S, Ozduman K, Harmanci A, Clark V, Baranoski J, Gunel J, Pamir M, Bilguvar K, Yasuno K, Vortmeyer A, Huttner A, Sander C, Gunel M. GENO-15IDENTIFICATION AND GENOMIC ANALYSIS OF HYPER-MUTATED AND ULTRA-MUTATED GBMS Neuro-Oncology 2015, 17: v94-v94. PMCID: PMC4638807, DOI: 10.1093/neuonc/nov215.15.
Mutations in the Type IV Collagens, COL4A1 and COL4A2 are Associated with Intraventricular Hemorrhage in Preterm Infants
DiLuna M, Bilguvar K, Louvi A, Bizzarro M, Bayrakli F, Bayri Y, Bydon M, Schneider K, Duncan C, State M, Lifton R, Ment L, Gunel M. Mutations in the Type IV Collagens, COL4A1 and COL4A2 are Associated with Intraventricular Hemorrhage in Preterm Infants Neurosurgery 2009, 65: 419. DOI: 10.1227/01.neu.0000358727.92507.ea.
Linkage and Copy Number Variation Analysis of Large Families and Sibling Pairs Demonstrates Locus Heterogeneity for Familial Intracranial Aneurysms
Bilguvar K, Bayrakli F, Bayri Y, Ozturk A, DiLuna M, Bydon M, Gunel M. Linkage and Copy Number Variation Analysis of Large Families and Sibling Pairs Demonstrates Locus Heterogeneity for Familial Intracranial Aneurysms Neurosurgery 2007, 61: 198. DOI: 10.1227/01.neu.0000279890.51914.ec.
Contributor's List
Berkovic S, Bilguvar K, Blackstone C, Bloch M, Blumenfeld H, Bredesen D, Bressman S, Brucal M, Burton E, Dalmau J, Dawson T, Dawson V, Depondt C, DiLuna M, DiMauro S, Ferrari M, Fink D, Flügel A, Frants R, Glorioso J, Goadsby P, Goldin A, Gunel M, Harel N, Helbig I, Hemmen T, Hisama F, Hyman B, Ingelsson M, Johnson D, Kamholz J, Kaul M, Kocsis J, Lammers G, Leckman J, Li J, Lipton S, Maragakis N, Mehlen P, Morimoto R, Orton K, Overeem S, Ozelius L, Pandolfo M, Pascual J, Paulson H, Peroutka S, Petroff O, Ransom C, Rao R, Rismanchi N, Rothstein J, Savitt J, Scheffer I, Schon E, Shy M, Strittmatter S, Tafti M, Tanriover G, Todi S, van den Maagdenberg A, Vance J, Vincent A, Voisine C, Waxman S, Wekerle H, Williams A, Wood J, Yang Y, Zivin J. Contributor's List 2007, vii-ix. DOI: 10.1016/b978-012369509-3.50001-9.
13 Hemorrhagic Brain Disease
DiLuna M, Bilguvar K, Tanriover G, Gunel M. 13 Hemorrhagic Brain Disease 2007, 187-205. DOI: 10.1016/b978-012369509-3.50015-9.
Hypertension, Age, and Location Predict Rupture of Small Intracranial Aneurysms
Nahed B, DiLuna M, Morgan T, Ocal E, Hawkins A, Ozduman K, Kahle K, Chamberlain A, Amar A, Gunel M. Hypertension, Age, and Location Predict Rupture of Small Intracranial Aneurysms Neurosurgery 2005, 57: 676-683. DOI: 10.1093/neurosurgery/57.4.676.
765 Genome-wide Linkage Analysis of Intracranial Aneurysms
Nahed B, Hawkins A, Diluna M, Seker A, Guclu B, Chamberlain A, State M, Gunel M. 765 Genome-wide Linkage Analysis of Intracranial Aneurysms Neurosurgery 2004, 55: 474. DOI: 10.1097/00006123-200408000-00101.
765 Genome-wide Linkage Analysis of Intracranial Aneurysms
Nahed B, Hawkins A, Diluna M, Seker A, Guclu B, Chamberlain A, State M, Gunel M. 765 Genome-wide Linkage Analysis of Intracranial Aneurysms Neurosurgery 2004, 55: 474-474. DOI: 10.1227/00006123-200408000-00101.

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Titles

Nixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neuroscience
Chair, Neurosurgery
Chief, Neurosurgery, Yale New Haven Health System
Chair, Perioperative Executive Leadership Committee
Member, National Academy of Medicine
Co-Director, Yale Program on Neurogenetics

Education & Training

Chief Resident
Yale-New Haven Hospital (1998)
Resident
Yale-New Haven Hospital (1997)
Intern
Yale-New Haven Hospital (1992)
MD
Istanbul University (1991)

Languages Spoken

English
Türkçe (Turkish)

Additional Information

Honors & Recognitions

Publications

P11.46.A Whole exome sequencing identifies novel SLIT2 mutations in primary CNS lymphoma
Kaulen L, Erson-Omay E, Henegariu O, Karschnia P, Huttner A, Günel M, Baehring J. P11.46.A Whole exome sequencing identifies novel SLIT2 mutations in primary CNS lymphoma Neuro-Oncology 2022, 24: ii68-ii68. PMCID: PMC9443199, DOI: 10.1093/neuonc/noac174.235.
Abstract 3312: A CRISPR-Cas9 screen in meningioma reveals GCN2/ATF4 is a novel target that enhances the response to radiation
Baro M, Gunel M, Moliterno J, Contessa J. Abstract 3312: A CRISPR-Cas9 screen in meningioma reveals GCN2/ATF4 is a novel target that enhances the response to radiation Cancer Research 2022, 82: 3312-3312. DOI: 10.1158/1538-7445.am2022-3312.
The quest to unravel the complex genomics of intracranial aneurysms
Barak T, Günel M. The quest to unravel the complex genomics of intracranial aneurysms Nature Cardiovascular Research 2022, 1: 281-282. DOI: 10.1038/s44161-022-00051-7.
Clinical Implications of the Genomic Profiling of Sporadic Multiple Meningiomas
Vetsa S, Vasandani S, Barak T, Yalcin K, Jalal M, Nadar A, Aguilera S, Mishra-Gorur K, Miyagishima D, Marianayanam N, Fulbright R, McGuone D, Günel M, Erson-Omay E, Moliterno J. Clinical Implications of the Genomic Profiling of Sporadic Multiple Meningiomas Journal Of Neurological Surgery Part B Skull Base 2022, 83: s1-s270. DOI: 10.1055/s-0042-1743783.
TRAF7 Mutated Subgroups Differ in Sphenoid Wing Meningiomas with Hyperostosis
Jin L, Vetsa S, Vasandani S, Nadar A, Youngblood M, Gupte T, Barak T, Yalcin K, Aguilera S, Mishra-Gorur K, Blondin N, Gorelick E, Omay S, Pointdujour-Lim R, Judson B, Alperovich M, Aboian M, Marianayagam N, McGuone D, Gunel M, Erson-Omay Z, Fulbright R, Moliterno J. TRAF7 Mutated Subgroups Differ in Sphenoid Wing Meningiomas with Hyperostosis Journal Of Neurological Surgery Part B Skull Base 2022, 83: s1-s270. DOI: 10.1055/s-0042-1743640.
NF2 Mutant Sporadic Meningiomas Differ Based on Location Relative to the Tentorium
Vasandani S, Vetsa S, Jalal M, Kanat Y, Marianayagam N, Jin L, Fulbright R, Erson-Omay E, Gunel M, Moliterno J. NF2 Mutant Sporadic Meningiomas Differ Based on Location Relative to the Tentorium Journal Of Neurological Surgery Part B Skull Base 2022, 83: s1-s270. DOI: 10.1055/s-0042-1743734.
Abstract 105: Polygenic Burden Of Hypertension-related Alleles Leads To Non-traumatic Subarachnoid Hemorrhage At Younger Ages
Vanent K, Acosta J, Both C, Leasure A, Noche R, Levitt M, Matouk C, Gunel M, Sheth K, Falcone G. Abstract 105: Polygenic Burden Of Hypertension-related Alleles Leads To Non-traumatic Subarachnoid Hemorrhage At Younger Ages Stroke 2022, 53: a105-a105. DOI: 10.1161/str.53.suppl_1.105.
EPCO-29. GENOMIC PROFILING OF SPORADIC MULTIPLE MENINGIOMAS
Erson-Omay Z, Barak T, Vetsa S, Nadar A, Miyagishima D, Yalcin K, Aguilera S, Mishra-Gorur K, McGuone D, Fulbright R, Gunel M, Moliterno-Gunel J. EPCO-29. GENOMIC PROFILING OF SPORADIC MULTIPLE MENINGIOMAS Neuro-Oncology 2021, 23: vi8-vi8. DOI: 10.1093/neuonc/noab196.028.
INNV-09. SURGICAL STRATEGIES FOR OLDER PATIENTS WITH GLIOBLASTOMA
Barak T, Hwang L, Chen J, Jin L, Miyagishima D, Yalcin K, Ogilvie S, Antonios J, Theriault B, Huttner A, McGuone D, Lifton N, Blondin N, Corbin Z, Zhang Y, Gunel M, Erson-Omay Z, Fulbright R, Tabar T, Moliterno-Gunel J. INNV-09. SURGICAL STRATEGIES FOR OLDER PATIENTS WITH GLIOBLASTOMA Neuro-Oncology 2021, 23: vi107-vi107. PMCID: PMC8598632, DOI: 10.1093/neuonc/noab196.421.
NIMG-64. TYPE OF BONY INVOLVEMENT PREDICTS GENOMIC SUBGROUP IN SPHENOID WING MENINGIOMAS
Jin L, Youngblood M, Gupte T, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera S, Mishra-Gorur K, Blondin N, Omay S, Pointdujour-Lim R, Judson B, Alperovich M, Aboian M, McGuone D, Gunel M, Erson-Omay Z, Fulbright R, Moliterno J. NIMG-64. TYPE OF BONY INVOLVEMENT PREDICTS GENOMIC SUBGROUP IN SPHENOID WING MENINGIOMAS Neuro-Oncology 2021, 23: vi144-vi144. PMCID: PMC8598770, DOI: 10.1093/neuonc/noab196.562.
Abstract P412: Klotho -vS Heterozygosity is Associated With Lower Risk of Non-Traumatic Subarachnoid Hemorrhage
Acosta J, Szejko N, Torres Lopez V, Both C, Sansing L, Sheth K, Matouk C, Gunel M, Falcone G. Abstract P412: Klotho -vS Heterozygosity is Associated With Lower Risk of Non-Traumatic Subarachnoid Hemorrhage Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p412.
The Genomic Landscape of Meningiomas
Zhao A, Youngblood M, Erson-Omay E, Moliterno J, Gunel M. The Genomic Landscape of Meningiomas 2020, 35-55. DOI: 10.1007/978-3-030-59558-6_4.
Clinical and Genomic Factors Associated With Seizures in Meningiomas
Gupte T, Jin L, Li C, Yalcin K, Youngblood M, Miyagishima D, Gorur K, Zhao A, Fulbright R, Omay Z, Gunel M, Moliterno Gunel J. Clinical and Genomic Factors Associated With Seizures in Meningiomas Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_796.
NCOG-50. CLINICAL AND GENOMIC FACTORS ASSOCIATED WITH SEIZURES IN MENINGIOMAS
Gupte T, Jin L, Li C, Yalcin K, Youngblood M, Miyagishima D, Mishra K, Fulbright R, Erson-omay Z, Gunel M, Moliterno J. NCOG-50. CLINICAL AND GENOMIC FACTORS ASSOCIATED WITH SEIZURES IN MENINGIOMAS Neuro-Oncology 2020, 22: ii140-ii140. PMCID: PMC7651386, DOI: 10.1093/neuonc/noaa215.588.
PATH-39. ASSOCIATIONS OF GENOMIC SUBGROUP WITH RECURRENCE IN LOW-GRADE MENINGIOMAS
Youngblood M, Miyagishima D, Jin L, Gupte T, Li C, Duran D, Montejo J, Zhao A, Sheth A, Tyrtova E, Özduman K, Iacoangeli F, Peyre M, Boetto J, Pease M, Avşar T, Huttner A, Bilguvar K, Kilic T, Pamir M, Amankulor N, Kalamarides M, Erson-omay Z, Gunel M, Moliterno J. PATH-39. ASSOCIATIONS OF GENOMIC SUBGROUP WITH RECURRENCE IN LOW-GRADE MENINGIOMAS Neuro-Oncology 2020, 22: ii172-ii173. PMCID: PMC7651600, DOI: 10.1093/neuonc/noaa215.720.
Micro-RNA Mutations Across Multiple Resections of a Giant Nonfunctional Pituitary Adenoma
Gummadavelli A, McCarthy L, Erson Z, Vining E, Gunel M, Omay S. Micro-RNA Mutations Across Multiple Resections of a Giant Nonfunctional Pituitary Adenoma Journal Of Neurological Surgery Part B Skull Base 2020, 81: s1-s272. DOI: 10.1055/s-0040-1702680.
Abstract 66: Causal Associations Between Genetically-determined Smoking and Risk of Subarachnoid Hemorrhage
Acosta J, Both C, Brown S, Leasure A, Vanent K, Noche R, Kirsch E, Petersen N, Matouk C, Gunel M, Gill T, Sheth K, Falcone G. Abstract 66: Causal Associations Between Genetically-determined Smoking and Risk of Subarachnoid Hemorrhage Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.66.
Abstract 71: Sex and Genetic Predisposition Synergistically Influence Risk of Stroke and Myocardial Infarction in Middle-Aged Persons Without Risk Factors
Falcone G, Acosta J, Leasure A, Vanent K, Noche R, Kirsch E, Petersen N, Schindler J, Sansing L, Gill T, Matouk C, Gunel M, Sheth K. Abstract 71: Sex and Genetic Predisposition Synergistically Influence Risk of Stroke and Myocardial Infarction in Middle-Aged Persons Without Risk Factors Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.71.
GENE-56. MENINGIOMA GENOMIC SUBGROUP AS A PREDICTOR OF POST-OPERATIVE PATIENT OUTCOMES: IMPLICATIONS FOR TREATMENT AND FOLLOW-UP
Youngblood M, Sheth A, Zhao A, Montejo J, Duran D, Li C, Tyrtova E, Özduman K, Peyre M, Boetto J, Omay S, Kalamarides M, Zeynep Erson-Omay E, Günel M, Moliterno J. GENE-56. MENINGIOMA GENOMIC SUBGROUP AS A PREDICTOR OF POST-OPERATIVE PATIENT OUTCOMES: IMPLICATIONS FOR TREATMENT AND FOLLOW-UP Neuro-Oncology 2019, 21: vi109-vi110. PMCID: PMC6846980, DOI: 10.1093/neuonc/noz175.458.
Identification of Peptidyl-Prolyl Cis-Trans Isomerase-Like 4 as a Disease Causing Gene in Intracranial Aneurysms and its Role in Vertebrate CNS Specific Angiogenesis
Barak T, Sencicek A, Miyagishima D, Henegariu O, Gorur K, Bilguvar K, Gunel M. Identification of Peptidyl-Prolyl Cis-Trans Isomerase-Like 4 as a Disease Causing Gene in Intracranial Aneurysms and its Role in Vertebrate CNS Specific Angiogenesis Neurosurgery 2019, 66: 310-303. DOI: 10.1093/neuros/nyz310_303.
Outcome Analysis Among Meningioma Genomic Subgroups Identifies Decreased Recurrence Free Survival in PI3K Activated Tumors
Youngblood M, Sheth A, Zhao A, Montejo J, Duran D, Li C, Tyrtova E, Ozduman K, Miyagishima D, Boetto J, Peyre M, Omay S, Kalamarides M, Omay Z, Gunel M, Moliterno J. Outcome Analysis Among Meningioma Genomic Subgroups Identifies Decreased Recurrence Free Survival in PI3K Activated Tumors Neurosurgery 2019, 66: 310-646. DOI: 10.1093/neuros/nyz310_646.
Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis
Timberlake AT, Jin SC, Nelson-Williams C, Wu R, Furey CG, Islam B, Haider S, Loring E, Galm A, Steinbacher D, Larysz D, Staffenberg D, Flores R, Rodriguez E, Boggon T, Persing J, Lifton R, Lifton RP, Gunel M, Mane S, Bilguvar K, Gerstein M, Loring E, Nelson-Williams C, Lopez F, Knight J. Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 15116-15121. PMID: 31292255, PMCID: PMC6660739, DOI: 10.1073/pnas.1902041116.
P04.60 Genomic profile of tumorigenesis in a patient with Turcot syndrome
Karschnia P, Erson-Omay E, Huttner A, Fulbright R, Günel M, Baehring J. P04.60 Genomic profile of tumorigenesis in a patient with Turcot syndrome Neuro-Oncology 2018, 20: iii293-iii293. PMCID: PMC6143975, DOI: 10.1093/neuonc/noy139.294.
116 Exome Sequencing Uncovers Molecular Determinants of Trigeminal Neuralgia
Choi J, Zeng X, Jin S, Gaillard J, Duran D, Nelson-Williams C, Panchagnula S, Dib-Hajj S, Barker F, Sekula R, Waxman S, Gunel M, Lifton R, T. K. 116 Exome Sequencing Uncovers Molecular Determinants of Trigeminal Neuralgia Neurosurgery 2018, 65: 85-86. DOI: 10.1093/neuros/nyy303.116.
141 Meningioma With Multiple Drivers
Tyrtova E, Li C, Youngblood M, Duran D, Montejo J, Coskun S, Miyagishima D, Bilguvar K, Gunel M. 141 Meningioma With Multiple Drivers Neurosurgery 2018, 65: 94. DOI: 10.1093/neuros/nyy303.141.
9p24 triplication in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus
Furey C, Antwi P, Duran D, Timberlake AT, Nelson-Williams C, Matouk CC, DiLuna ML, Günel M, Kahle KT. 9p24 triplication in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus Molecular Case Studies 2018, 4: a003145. PMID: 29895553, PMCID: PMC6169828, DOI: 10.1101/mcs.a003145.
Predictors of Vessel Wall Enhancement in Unruptured Intracranial Aneurysms
Sommaruga S, Cord B, Santarosa C, Malhotra A, Jonhson M, Sheth K, Gunel M, Herbert R, Bijlenga P, Schaller K, Falcone G, Matouk C. Predictors of Vessel Wall Enhancement in Unruptured Intracranial Aneurysms Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660769.
Abstract WMP31: Vessel Wall Enhancement is Associated With Clinical and Imaging Markers of Aneurysm Instability
Sommaruga S, Cord B, Molhotra A, Johnson M, Minja F, Gunel M, Sheth K, Herbert R, Melnikov F, Schaller K, Mandell D, Bijlenga P, Falcone G, Matouk C. Abstract WMP31: Vessel Wall Enhancement is Associated With Clinical and Imaging Markers of Aneurysm Instability Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wmp31.
Production of 2-Hydroxyglutarate by IDH Mutant Malignancies Induces a BRCAness State That Can be Exploited By PARP Inhibitors and Radiation
Corso C, Bindra R, Glazer P, Sulkowski P, Robinson N, Scanlon S, Purshouse K, Bai H, Liu Y, Sundaram R, Hegan D, Fons N, Breuer G, Song Y, Mishra-Gorur K, De Feyter H, de Graaf R, Surovtseva Y, Kachman M, Halene S, Gunel M. Production of 2-Hydroxyglutarate by IDH Mutant Malignancies Induces a BRCAness State That Can be Exploited By PARP Inhibitors and Radiation International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e68. DOI: 10.1016/j.ijrobp.2017.06.754.
102 Exome Sequencing Identifies Novel Molecular Determinants of Human Congenital Hydrocephalus
Furey C, Choi J, Duran D, Timberlake A, Zeng X, Nelson-Williams C, Khanna A, Iskandar B, Butler W, Heuer G, Bayri Y, Sahin Y, Limbrick D, Warf B, Duncan C, DiLuna M, Gunel M, Lifton R, Kahle K. 102 Exome Sequencing Identifies Novel Molecular Determinants of Human Congenital Hydrocephalus Neurosurgery 2017, 64: 220. DOI: 10.1093/neuros/nyx417.102.
168 Wall Enhancement in Unruptured Aneurysms is Associated with Symptomatic Presentation and Size
Cord B, Sommaruga S, Hebert R, Malhotra A, Johnson M, Minja F, Gunel M, Sheth K, Falcone G, Matouk C. 168 Wall Enhancement in Unruptured Aneurysms is Associated with Symptomatic Presentation and Size Neurosurgery 2017, 64: 243. DOI: 10.1093/neuros/nyx417.168.
Personalized Medicine Through Advanced Genomics
Youngblood M, Erson-Omay E, Günel M. Personalized Medicine Through Advanced Genomics 2016, 31-48. DOI: 10.1007/978-3-319-49864-5_3.
GENO-15IDENTIFICATION AND GENOMIC ANALYSIS OF HYPER-MUTATED AND ULTRA-MUTATED GBMS
Erson-Omay E, Schultz N, Omay S, Ozduman K, Harmanci A, Clark V, Baranoski J, Gunel J, Pamir M, Bilguvar K, Yasuno K, Vortmeyer A, Huttner A, Sander C, Gunel M. GENO-15IDENTIFICATION AND GENOMIC ANALYSIS OF HYPER-MUTATED AND ULTRA-MUTATED GBMS Neuro-Oncology 2015, 17: v94-v94. PMCID: PMC4638807, DOI: 10.1093/neuonc/nov215.15.
Mutations in the Type IV Collagens, COL4A1 and COL4A2 are Associated with Intraventricular Hemorrhage in Preterm Infants
DiLuna M, Bilguvar K, Louvi A, Bizzarro M, Bayrakli F, Bayri Y, Bydon M, Schneider K, Duncan C, State M, Lifton R, Ment L, Gunel M. Mutations in the Type IV Collagens, COL4A1 and COL4A2 are Associated with Intraventricular Hemorrhage in Preterm Infants Neurosurgery 2009, 65: 419. DOI: 10.1227/01.neu.0000358727.92507.ea.
Linkage and Copy Number Variation Analysis of Large Families and Sibling Pairs Demonstrates Locus Heterogeneity for Familial Intracranial Aneurysms
Bilguvar K, Bayrakli F, Bayri Y, Ozturk A, DiLuna M, Bydon M, Gunel M. Linkage and Copy Number Variation Analysis of Large Families and Sibling Pairs Demonstrates Locus Heterogeneity for Familial Intracranial Aneurysms Neurosurgery 2007, 61: 198. DOI: 10.1227/01.neu.0000279890.51914.ec.
Contributor's List
Berkovic S, Bilguvar K, Blackstone C, Bloch M, Blumenfeld H, Bredesen D, Bressman S, Brucal M, Burton E, Dalmau J, Dawson T, Dawson V, Depondt C, DiLuna M, DiMauro S, Ferrari M, Fink D, Flügel A, Frants R, Glorioso J, Goadsby P, Goldin A, Gunel M, Harel N, Helbig I, Hemmen T, Hisama F, Hyman B, Ingelsson M, Johnson D, Kamholz J, Kaul M, Kocsis J, Lammers G, Leckman J, Li J, Lipton S, Maragakis N, Mehlen P, Morimoto R, Orton K, Overeem S, Ozelius L, Pandolfo M, Pascual J, Paulson H, Peroutka S, Petroff O, Ransom C, Rao R, Rismanchi N, Rothstein J, Savitt J, Scheffer I, Schon E, Shy M, Strittmatter S, Tafti M, Tanriover G, Todi S, van den Maagdenberg A, Vance J, Vincent A, Voisine C, Waxman S, Wekerle H, Williams A, Wood J, Yang Y, Zivin J. Contributor's List 2007, vii-ix. DOI: 10.1016/b978-012369509-3.50001-9.
13 Hemorrhagic Brain Disease
DiLuna M, Bilguvar K, Tanriover G, Gunel M. 13 Hemorrhagic Brain Disease 2007, 187-205. DOI: 10.1016/b978-012369509-3.50015-9.
Hypertension, Age, and Location Predict Rupture of Small Intracranial Aneurysms
Nahed B, DiLuna M, Morgan T, Ocal E, Hawkins A, Ozduman K, Kahle K, Chamberlain A, Amar A, Gunel M. Hypertension, Age, and Location Predict Rupture of Small Intracranial Aneurysms Neurosurgery 2005, 57: 676-683. DOI: 10.1093/neurosurgery/57.4.676.
765 Genome-wide Linkage Analysis of Intracranial Aneurysms
Nahed B, Hawkins A, Diluna M, Seker A, Guclu B, Chamberlain A, State M, Gunel M. 765 Genome-wide Linkage Analysis of Intracranial Aneurysms Neurosurgery 2004, 55: 474. DOI: 10.1097/00006123-200408000-00101.
765 Genome-wide Linkage Analysis of Intracranial Aneurysms
Nahed B, Hawkins A, Diluna M, Seker A, Guclu B, Chamberlain A, State M, Gunel M. 765 Genome-wide Linkage Analysis of Intracranial Aneurysms Neurosurgery 2004, 55: 474-474. DOI: 10.1227/00006123-200408000-00101.

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Yale Physicians Building
800 Howard Avenue, Ste 3rd Floor
New Haven, CT 06519
- 1-203-737-2096
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