1
Liver Clinic
Bridgeport Hospital-226 Mill Hill Avenue
226 Mill Hill Avenue
Bridgeport, CT 06610
1 of 2
- Liver ClinicBridgeport Hospital-226 Mill Hill Avenue226 Mill Hill AvenueBridgeport, CT 06610
- Yale Digestive DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510
Michael H Nathanson, MD, PhD
Internal Medicine, Hepatology
Telehealth is available
Patient type treated
Adult
Accepting new patients
Yes
Referral required
From patients or physicians
Board Certified in
Gastroenterology and Internal Medicine
Biography
Michael H. Nathanson, MD, PhD, specializes in treating patients with liver disease.
He is a professor of medicine (digestive diseases) and of cell biology at Yale School of Medicine. In addition to his clinical work, he serves as section chief of digestive diseases; director of both the Yale Liver Center and the Center for Cell and Molecular Imaging; and an active researcher.
Titles
- Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology
- Director, Yale Liver Center
- Director, Center for Cell and Molecular Imaging
Education & Training
- Postdoctoral FellowYale University (1990)
- ResidentColumbia-Presbyterian Medical Center (1988)
- MDCase Western Reserve Univ (1985)
- PhDCase Western Reserve Univ (1983)
- MSMassachusetts Institute of Technology (1977)
- BSUniversity of California, Berkeley (1976)
Additional Information
Honors & Recognitions
- Assoc of American Physicians (AAP): (2017)
- American Society for Clinical Investigation (ASCI): (2017)
- FAPESP Fullbright Scholar: (2007)
Board Certifications
- AB of Internal Medicine, Internal Medicine (1988)
Professional Service
- Hepatology (2012 - 2016): Editor
- VA (2009 - Present): Medical Research Eligibility Committee
- AASLD (2009 - Present): Nominating Committee, Abstract Review Committee
- NIH (2009 - Present): Special Emphasis panel ZDK1 GRB-8
- NIH (2008 - 2009): Shared Instrument Grant Study Section
- NIH (2007 - Present): Special Emphasis Panel ZDK1 GRB-G
- NIH (2002 - 2006): Shared Instrument Grant Study Section
Publications
- Herta T, Kersten R, Chang J, Hubers L, Go S, Tolenaars D, Paulusma C, Nathanson M, Elferink R, van de Graaf S, Beuers U. Serum autoantibodies against annexin A11 might weaken the biliary bicarbonate umbrella in IgG4-related cholangitis. Zeitschrift Für Gastroenterologie 2023, 61: e448-e448. DOI: 10.1055/s-0043-1771806.
- LAMOIA T, HUBBARD B, GUERRA M, GOODMAN R, NATHANSON M, SHULMAN G. 1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo. Diabetes 2023, 72 DOI: 10.2337/db23-1558-p.
- Guerra M, Nathanson M. Above the legal limit: Alcohol brings ER and mitochondria too close together. Cell Calcium 2023, 113: 102763. PMID: 37235972, PMCID: PMC10726477, DOI: 10.1016/j.ceca.2023.102763.
- Arumugam S, Li B, Boodapati S, Nathanson M, Sun B, Ouyang X, Mehal W. Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation. Hepatology 2023, 78: 1448-1461. PMID: 37013923, PMCID: PMC10804318, DOI: 10.1097/hep.0000000000000388.
- Loyola-Machado A, Guerra M, Nathanson M. Mitochondrial calcium signaling in cholangiocarcinoma. Hepatoma Research 2023, 9: null-null. DOI: 10.20517/2394-5079.2023.28.
- LAMOIA T, HUBBARD B, GUERRA M, GOODMAN R, NATHANSON M, MOOTHA V, SHULMAN G. 219-LB: The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial Oxidation. Diabetes 2022, 71 DOI: 10.2337/db22-219-lb.
- Takeuchi M, Vidigal P, Guerra M, Hundt M, Robert M, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, Banales J, Nathanson M, Weerachayaphorn J. AS080 Interaction between neutrophils and cholangiocytes causes cholestasis in alcoholic hepatitis. Journal Of Hepatology 2020, 73: s58-s59. DOI: 10.1016/s0168-8278(20)30659-0.
- Hernandez E, Nathanson M. Calcium Signaling in Cholangiocytes. 2020, 105-111. DOI: 10.1201/9780367813888-10.
- McLaren G, Nathanson M, Saidel G. Compartmental analysis of intestinal iron absorption and mucosal iron kinetics. 2020, 187-204. DOI: 10.1201/9780367811716-20.
- Guerra M, Leite M, Nathanson M. Ca2+ Signaling in the Liver. 2020, 496-508. DOI: 10.1002/9781119436812.ch40.
- Leite M, Guerra M, Andrade V, Nathanson M. Signaling pathways in biliary epithelial cells. 2015, 15-33. DOI: 10.1002/9781118663387.ch2.
- Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH. Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes. Gastroenterology 2015, 149: 211-222.e10. PMID: 25796361, PMCID: PMC4478166, DOI: 10.1053/j.gastro.2015.03.014.
- Omary MB, Wallace MB, El‐Omar E, Jalan R, Nathanson MH. A multi‐journal partnership to highlight joint first‐authors of manuscripts. Hepatology 2015, 61: 416-417. PMID: 25476851, DOI: 10.1002/hep.27631.
- Amaya MJ, Oliveira AG, Schroeder LK, Allgeyer ES, Bewersdorf J, Nathanson MH. Apical Localization of Inositol 1,4,5-Trisphosphate Receptors Is Independent of Extended Synaptotagmins in Hepatocytes. PLOS ONE 2014, 9: e114043. PMID: 25437447, PMCID: PMC4250053, DOI: 10.1371/journal.pone.0114043.
- Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH. Post-translational Regulation of the Type III Inositol 1,4,5-Trisphosphate Receptor by miRNA-506*. Journal Of Biological Chemistry 2014, 290: 184-196. PMID: 25378392, PMCID: PMC4281721, DOI: 10.1074/jbc.m114.587030.
- Wong S, Nathanson M, Chen J, Jain D. Evaluation of Barrett Esophagus by Multiphoton Microscopy. Archives Of Pathology & Laboratory Medicine 2014, 138: 204-12. PMID: 24476518, PMCID: PMC4089503, DOI: 10.5858/arpa.2012-0675-oa.
- Amaya MJ, Oliveira AG, Guimarães ES, Casteluber MC, Carvalho SM, Andrade LM, Pinto MC, Mennone A, Oliveira CA, Resende RR, Menezes GB, Nathanson MH, Leite MF. The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology 2013, 59: 274-283. PMID: 23839970, PMCID: PMC3823683, DOI: 10.1002/hep.26609.
- Nathanson M. Something old, something new. Hepatology 2011, 55: 1-2. DOI: 10.1002/hep.24817.
- Melo F, Guerra M, Andrade V, Fonseca E, Souza-Fagundes E, Menezes G, de Paula A, Nathanson M, Leite M. Mitochondrial Calcium Regulates Liver Regeneration Through Modulation of Apoptosis. Gastroenterology 2011, 140: s-472. DOI: 10.1016/s0016-5085(11)61941-0.
- Reed A, Husain S, Gorelick F, Nathanson M. Low pH Inhibits Gap Junction Communication in the Pancreatic Acinar Cell. Gastroenterology 2011, 140: s-385. DOI: 10.1016/s0016-5085(11)61577-1.
- Kruglov E, Gautam S, Nathanson M. 539 Inositol 1,4,5-Trisphosphate Receptor Type 2 Modulates Bsep Activity in Hepatocytes. Gastroenterology 2010, 138: s-791. DOI: 10.1016/s0016-5085(10)63642-6.
- Guerra M, Cruz L, Kruglov E, Garcia C, Chen J, Nathanson M. 538 Regulation of MRP2 by Calcium Signaling. Gastroenterology 2010, 138: s-790. DOI: 10.1016/s0016-5085(10)63641-4.
- Chaudhuri A, Shah A, Husain S, Gorelick F, Nathanson M. T1935 Low pH Enhances Calcium Signaling in the Pancreatic Acinar Cell. Gastroenterology 2010, 138: s-610. DOI: 10.1016/s0016-5085(10)62812-0.
- 537 The Epidermal Growth Factor Receptor (EGFR) Reaches the Nucleus via a Caveolin-Dependent PathwayRodrigues M, Campos A, Goes A, Nathanson M, Gomes D. 537 The Epidermal Growth Factor Receptor (EGFR) Reaches the Nucleus via a Caveolin-Dependent Pathway. Gastroenterology 2010, 138: s-790. DOI: 10.1016/s0016-5085(10)63640-2.
- Shieh F, Nathanson M, Drumm H, Jamidar P. S1426: High-Definition In-Vivo Probe-Based Confocal Laser Endomicroscopy of the Common Bile Duct. Gastrointestinal Endoscopy 2010, 71: ab158-ab159. DOI: 10.1016/j.gie.2010.03.200.
- Leite M, Andrade V, Nathanson M. Signaling Pathways in Biliary Epithelial Cells. 2009, 25-39. DOI: 10.1007/978-3-642-00150-5_2.
- Leite F, Guerra M, Nathanson M. Ca2+ Signaling in the Liver. 2009, 485-510. DOI: 10.1002/9780470747919.ch32.
- Loeser C, Nathanson M, Jamidar P. Probe-based Laser Confocal Endomicroscopy for the Diagnosis of Biliary Malignancies. The American Journal Of Gastroenterology 2009, 104: s75-s76. DOI: 10.14309/00000434-200910003-00193.
- Andrade V, Jardim C, Melo F, Silva W, Nathanson M, Ortega J, Leite M. 87 Nucleoplasmic Calcium Regulates Proliferation of Hepatocytes Through Legumain and Reticulon4. Gastroenterology 2009, 136: a-792. DOI: 10.1016/s0016-5085(09)63653-2.
- Lagoudakis L, Garcin I, Nahum K, Combettes L, Nathanson M, Tordjmann T. 521 CYTOSOLIC CALCIUM MEDIATES LIVER REGENERATION IN THE RAT. Journal Of Hepatology 2008, 48: s196. DOI: 10.1016/s0168-8278(08)60523-1.
- Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM, Nathanson MH. c-Met Must Translocate to the Nucleus to Initiate Calcium Signals* ♦. Journal Of Biological Chemistry 2007, 283: 4344-4351. PMID: 18073207, PMCID: PMC2825875, DOI: 10.1074/jbc.m706550200.
- Renato P, Correa A, Nathanson M, Wolkoff A, Novikoff P, Thevananther S, Karpen S, Elferink R, Püschel G, Stieger B. Functions of the Liver. 2007, 89-128. DOI: 10.1002/9780470691861.ch2b.
- O'Brien EM, Gomes DA, Sehgal S, Nathanson MH. Hormonal Regulation of Nuclear Permeability* ♦. Journal Of Biological Chemistry 2006, 282: 4210-4217. PMID: 17158097, PMCID: PMC2835336, DOI: 10.1074/jbc.m606300200.
- Marius P, Guerra M, Nathanson M, Ehrlich B, Leite M. Corrigendum to “Calcium release from ryanodine receptors in the nucleoplasmic reticulum” [Cell Calcium 39 (2006) 65–73]. Cell Calcium 2006, 39: 551. DOI: 10.1016/j.ceca.2006.02.001.
- Husain S, Grant W, Kolodecik T, Nathanson M, Gorelick F. DISTINCT CALCIUM SIGNALS REGULATE PANCREATIC ZYMOGEN ACTIVATION. Pancreas 2005, 31: 446-447. DOI: 10.1097/01.mpa.0000193686.75459.3a.
- Nathanson M. Discussion of Basic Science Presentations. Journal Of Clinical Gastroenterology 2005, 39: s210. DOI: 10.1097/01.mcg.0000156106.75129.3f.
- Leite M, Nathanson M. Signaling Pathways in Biliary Epithelial Cells. 2005, 17-26. DOI: 10.1007/3-540-27194-5_2.
- Husain S, Prasad P, Kolodecik T, Nathanson M, Gorelick F. O0093 THE RYANODINE RECEPTOR MODULATES SECRETAGOGUE STIMULATED PANCREATIC ZYMOGEN ACTIVATION. Journal Of Pediatric Gastroenterology And Nutrition 2004, 39: s43-s44. DOI: 10.1097/00005176-200406001-00095.
- Echevarría W, Nathanson M. Gap Junctions in the Liver. 2004, 36-47. DOI: 10.1007/978-1-4419-9034-1_4.
- Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nature Cell Biology 2003, 5: 440-446. PMID: 12717445, PMCID: PMC3572851, DOI: 10.1038/ncb980.
- Guerra M, de Fatima Leite M, Echevarria W, Nathanson M. Ca2+ in the nucleus is independently regulated and has distinct effects on protein kinase C (PKC) in a liver cell line. Gastroenterology 2003, 124: a689. DOI: 10.1016/s0016-5085(03)83484-4.
- Shibao K, Hirata K, Robert M, Nathanson M. Loss of inositol 1,4,5-trisphosphate receptors from cholangiocytes is a final common pathway for cholestasis. Gastroenterology 2003, 124: a692. DOI: 10.1016/s0016-5085(03)83502-3.
- Leite MF, Thrower EC, Echevarria W, Koulen P, Hirata K, Bennett AM, Ehrlich BE, Nathanson MH. Nuclear and cytosolic calcium are regulated independently. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 2975-2980. PMID: 12606721, PMCID: PMC151451, DOI: 10.1073/pnas.0536590100.
- Pusl T, Nathanson M. Chronic Viral Hepatitis: Diagnosis and Therapeutics. Journal Of Clinical Gastroenterology 2002, 34: 496. DOI: 10.1097/00004836-200204000-00033.
- Dranoff J, Masyuk A, Kruglov E, LaRusso N, Nathanson M. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. AJP Gastrointestinal And Liver Physiology 2001, 281: g1059-g1067. PMID: 11557527, DOI: 10.1152/ajpgi.2001.281.4.g1059.
- Pusl T, Nathanson M. Transplantation of the Liver, Third Edition. Journal Of Clinical Gastroenterology 2001, 33: 347-348. DOI: 10.1097/00004836-200110000-00026.
- NATHANSON M, BURGSTAHLER A, MASYUK A, LaRUSSO N. Stimulation of ATP secretion in the liver by therapeutic bile acids. Biochemical Journal 2001, 358: 1-5. DOI: 10.1042/bj3580001.
- Hirata K, Nathanson M. Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver. Gastroenterology 2001, 121: 396-406. PMID: 11487549, DOI: 10.1053/gast.2001.26280.
- Spirlı̀ C, Nathanson M, Fiorotto R, Duner E, Denson L, Sanz J, Di Virgilio F, Okolicsanyi L, Casagrande F, Strazzabosco M. Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium. Gastroenterology 2001, 121: 156-169. PMID: 11438505, DOI: 10.1053/gast.2001.25516.
- HIRATA K, NATHANSON M. Bile duct epithelia regulate biliary bicarbonate excretion in the isolated bivascularly perfused rat liver. Gastroenterology 2001, 120: a357-a357. DOI: 10.1016/s0016-5085(01)81773-x.
- HIRATA K, ONEILL A, LEITE M, NATHANSON M. Regulation of Ca2+ signating in bile duct epithelia by InsP3 receptor isoforms. Gastroenterology 2001, 120: a91-a91. DOI: 10.1016/s0016-5085(01)80448-0.
- Hirata K, O'Neill A, Leite M, Nathanson M. Regulation of Ca2+ signating in bile duct epithelia by InsP3 receptor isoforms. Gastroenterology 2001, 120: a91. DOI: 10.1016/s0016-5085(08)80448-9.
- Hirata K, Nathanson M. Bile duct epithelia regulate biliary bicarbonate excretion in the isolated bivascularly perfused rat liver. Gastroenterology 2001, 120: a357. DOI: 10.1016/s0016-5085(08)81773-8.
- Dranoff J, O'Neill A, Franco A, Cai S, Connolly G, Ballatori N, Boyer J, Nathanson M. A Primitive ATP Receptor from the Little Skate Raja erinacea *. Journal Of Biological Chemistry 2000, 275: 30701-30706. PMID: 10900200, DOI: 10.1074/jbc.m003366200.
- Dranoff J, Nathanson M. It's swell to have ATP in the liver. Journal Of Hepatology 2000, 33: 323-325. PMID: 10952251, DOI: 10.1016/s0168-8278(00)80374-8.
- Leite M, Salgado A, Franco A, Burgstahler A, Nathanson M. CA2+ waves require sequential activation of inositol 1,4,5-trisphosphate receptors, then ryanodine receptors in pancreatic acinar cell. Gastroenterology 2000, 118: a875. DOI: 10.1016/s0016-5085(00)85639-5.
- Dranoff J, O’Neill A, Cai S, Franco A, Connelly G, Ballatori N, Boyer J, Nathanson M. Molecular identification of a primitive P2Y ATP receptor in liver from the little skate Raja erinacea. Gastroenterology 2000, 118: a911. DOI: 10.1016/s0016-5085(00)85777-7.
- Dranoff J, McClure M, Burgstahler A, Denson L, Crawford A, Crawford J, Karpen S, Nathanson M. Short‐term regulation of bile acid uptake by microfilament‐dependent translocation of rat ntcp to the plasma membrane. Hepatology 1999, 30: 223-229. PMID: 10385660, DOI: 10.1002/hep.510300136.
- Dranoff J, Nathanson M. Regulation of bile acid transport: Beyond molecular cloning. Hepatology 1999, 29: 1912-1913. PMID: 10347140, DOI: 10.1002/hep.510290643.
- Nathanson M, Rios–Velez L, Burgstahler A, Mennone A. Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. Gastroenterology 1999, 116: 1176-1183. PMID: 10220510, DOI: 10.1016/s0016-5085(99)70021-1.
- LEITE M, DRANOFF J, Ling G, NATHANSON M. Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells. Biochemical Journal 1999, 337: 305-309. DOI: 10.1042/bj3370305.
- Hagar R, Burgstahler A, Nathanson M, Ehrlich B. Type III InsP3 receptor channel stays open in the presence of increased calcium. Nature 1998, 396: 81-84. PMID: 9817204, PMCID: PMC2825878, DOI: 10.1038/23954.
- Hirata K, Nathanson M, Sears M. Novel paracrine signaling mechanism in the ocular ciliary epithelium. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 8381-8386. PMID: 9653195, PMCID: PMC20984, DOI: 10.1073/pnas.95.14.8381.
- Schmid S, Modlin I, Tang L, Stoch A, Rhee S, Nathanson M, Scheele G, Gorelick F. Telenzepine-sensitive muscarinic receptors on rat pancreatic acinar cells. American Journal Of Physiology 1998, 274: g734-g741. PMID: 9575856, DOI: 10.1152/ajpgi.1998.274.4.g734.
- Burgstahler A, Nathanson M. Coordination of calcium waves among hepatocytes: Teamwork gets the job done. Hepatology 1998, 27: 634-635. PMID: 9462668, DOI: 10.1002/hep.510270244.
- Jeffrey L, BURGSTAHLER A, NATHANSON M. Mechanism of long-range Ca2+ signalling in the nucleus of isolated rat hepatocytes. Biochemical Journal 1997, 326: 491-495. PMID: 9291123, PMCID: PMC1218696, DOI: 10.1042/bj3260491.
- Nathanson M, Fallon M, Burgstahler A, Mennone A, Schlosser S, Gonzalez C, Sáez J. Intercellular Calcium Signaling in Liver. 1997, 469-481. DOI: 10.1007/978-1-4899-1795-9_27.
- Fiarman G, Nathanson M, Brian West A, Deckelbaum L, Kelly L, Kapadia C. Differences in laser-induced autofluorescence between adenomatous and hyperplastic polyps and normal colonic mucosa by confocal microscopy. Digestive Diseases And Sciences 1995, 40: 1261-1268. PMID: 7781444, DOI: 10.1007/bf02065535.
- Nathanson M, Mariwalla K. Characterization and function of ATP receptors on hepatocytes from the little skate Raja erinacea. Gastroenterology 1995, 108: a1132. DOI: 10.1016/0016-5085(95)28828-7.
- Bruck R, Nathanson M, Roelofsen H, Boyer J. Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver. Hepatology 1994, 20: 1032-1040. PMID: 7927205, DOI: 10.1002/hep.1840200436.
- Nathanson M. Cellular and subcellular calcium signaling in gastrointestinal epithelium. Gastroenterology 1994, 106: 1349-1364. PMID: 8174894, DOI: 10.1016/0016-5085(94)90030-2.
- Beuers U, Nathanson M, Boyer J. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993, 104: 604-612. PMID: 8425704, DOI: 10.1016/0016-5085(93)90433-d.
- Rosales O, Isales C, Nathanson M, Sumpio B. Immunocytochemical expression and localization of protein kinase C in bovine aortic endothelial cells. Biochemical And Biophysical Research Communications 1992, 189: 40-46. PMID: 1449492, DOI: 10.1016/0006-291x(92)91522-r.
- Nathanson M, Gautam A, Bruck R, Isales C, Boyer J. Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver. Hepatology 1992, 15: 107-116. PMID: 1727785, DOI: 10.1002/hep.1840150119.
- Nathanson M, Boyer J. Mechanisms and regulation of bile secretion. Hepatology 1991, 14: 551-566. PMID: 1874500, DOI: 10.1002/hep.1840140324.
- Wisnieski J, Nathanson M, Anderson J, Davis A, Alper C, Naff G. Metabolism of C4 and linkage analysis in a kindred with hereditary incomplete C4 deficiency. Arthritis & Rheumatism 1987, 30: 919-926. PMID: 3477232, DOI: 10.1002/art.1780300812.
- Nathanson M, Saidel G, McLaren G. Analysis of iron kinetics: Identifiability, experiment design, and deterministic interpretations of a stochastic model. Mathematical Biosciences 1984, 68: 1-21. DOI: 10.1016/0025-5564(84)90072-5.
- Nathanson M, Hillman R, Georgakis C. Towards an optimal drug-delivery regimen for methotrexate chemotherapy. Applied Mathematics And Computation 1983, 12: 99-117. DOI: 10.1016/0096-3003(83)90002-4.
Departments and Programs
Locations
1
Liver Clinic
Bridgeport Hospital-226 Mill Hill Avenue
226 Mill Hill Avenue
Bridgeport, CT 06610
1 of 2
- Liver ClinicBridgeport Hospital-226 Mill Hill Avenue226 Mill Hill AvenueBridgeport, CT 06610
- Yale Digestive DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510
Biography
Michael H. Nathanson, MD, PhD, specializes in treating patients with liver disease.
He is a professor of medicine (digestive diseases) and of cell biology at Yale School of Medicine. In addition to his clinical work, he serves as section chief of digestive diseases; director of both the Yale Liver Center and the Center for Cell and Molecular Imaging; and an active researcher.
Titles
- Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology
- Director, Yale Liver Center
- Director, Center for Cell and Molecular Imaging
Education & Training
- Postdoctoral FellowYale University (1990)
- ResidentColumbia-Presbyterian Medical Center (1988)
- MDCase Western Reserve Univ (1985)
- PhDCase Western Reserve Univ (1983)
- MSMassachusetts Institute of Technology (1977)
- BSUniversity of California, Berkeley (1976)
Additional Information
Honors & Recognitions
- Assoc of American Physicians (AAP): (2017)
- American Society for Clinical Investigation (ASCI): (2017)
- FAPESP Fullbright Scholar: (2007)
Board Certifications
- AB of Internal Medicine, Internal Medicine (1988)
Professional Service
- Hepatology (2012 - 2016): Editor
- VA (2009 - Present): Medical Research Eligibility Committee
- AASLD (2009 - Present): Nominating Committee, Abstract Review Committee
- NIH (2009 - Present): Special Emphasis panel ZDK1 GRB-8
- NIH (2008 - 2009): Shared Instrument Grant Study Section
- NIH (2007 - Present): Special Emphasis Panel ZDK1 GRB-G
- NIH (2002 - 2006): Shared Instrument Grant Study Section
Publications
- Herta T, Kersten R, Chang J, Hubers L, Go S, Tolenaars D, Paulusma C, Nathanson M, Elferink R, van de Graaf S, Beuers U. Serum autoantibodies against annexin A11 might weaken the biliary bicarbonate umbrella in IgG4-related cholangitis. Zeitschrift Für Gastroenterologie 2023, 61: e448-e448. DOI: 10.1055/s-0043-1771806.
- LAMOIA T, HUBBARD B, GUERRA M, GOODMAN R, NATHANSON M, SHULMAN G. 1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo. Diabetes 2023, 72 DOI: 10.2337/db23-1558-p.
- Guerra M, Nathanson M. Above the legal limit: Alcohol brings ER and mitochondria too close together. Cell Calcium 2023, 113: 102763. PMID: 37235972, PMCID: PMC10726477, DOI: 10.1016/j.ceca.2023.102763.
- Arumugam S, Li B, Boodapati S, Nathanson M, Sun B, Ouyang X, Mehal W. Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation. Hepatology 2023, 78: 1448-1461. PMID: 37013923, PMCID: PMC10804318, DOI: 10.1097/hep.0000000000000388.
- Loyola-Machado A, Guerra M, Nathanson M. Mitochondrial calcium signaling in cholangiocarcinoma. Hepatoma Research 2023, 9: null-null. DOI: 10.20517/2394-5079.2023.28.
- LAMOIA T, HUBBARD B, GUERRA M, GOODMAN R, NATHANSON M, MOOTHA V, SHULMAN G. 219-LB: The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial Oxidation. Diabetes 2022, 71 DOI: 10.2337/db22-219-lb.
- Takeuchi M, Vidigal P, Guerra M, Hundt M, Robert M, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, Banales J, Nathanson M, Weerachayaphorn J. AS080 Interaction between neutrophils and cholangiocytes causes cholestasis in alcoholic hepatitis. Journal Of Hepatology 2020, 73: s58-s59. DOI: 10.1016/s0168-8278(20)30659-0.
- Hernandez E, Nathanson M. Calcium Signaling in Cholangiocytes. 2020, 105-111. DOI: 10.1201/9780367813888-10.
- McLaren G, Nathanson M, Saidel G. Compartmental analysis of intestinal iron absorption and mucosal iron kinetics. 2020, 187-204. DOI: 10.1201/9780367811716-20.
- Guerra M, Leite M, Nathanson M. Ca2+ Signaling in the Liver. 2020, 496-508. DOI: 10.1002/9781119436812.ch40.
- Leite M, Guerra M, Andrade V, Nathanson M. Signaling pathways in biliary epithelial cells. 2015, 15-33. DOI: 10.1002/9781118663387.ch2.
- Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH. Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes. Gastroenterology 2015, 149: 211-222.e10. PMID: 25796361, PMCID: PMC4478166, DOI: 10.1053/j.gastro.2015.03.014.
- Omary MB, Wallace MB, El‐Omar E, Jalan R, Nathanson MH. A multi‐journal partnership to highlight joint first‐authors of manuscripts. Hepatology 2015, 61: 416-417. PMID: 25476851, DOI: 10.1002/hep.27631.
- Amaya MJ, Oliveira AG, Schroeder LK, Allgeyer ES, Bewersdorf J, Nathanson MH. Apical Localization of Inositol 1,4,5-Trisphosphate Receptors Is Independent of Extended Synaptotagmins in Hepatocytes. PLOS ONE 2014, 9: e114043. PMID: 25437447, PMCID: PMC4250053, DOI: 10.1371/journal.pone.0114043.
- Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH. Post-translational Regulation of the Type III Inositol 1,4,5-Trisphosphate Receptor by miRNA-506*. Journal Of Biological Chemistry 2014, 290: 184-196. PMID: 25378392, PMCID: PMC4281721, DOI: 10.1074/jbc.m114.587030.
- Wong S, Nathanson M, Chen J, Jain D. Evaluation of Barrett Esophagus by Multiphoton Microscopy. Archives Of Pathology & Laboratory Medicine 2014, 138: 204-12. PMID: 24476518, PMCID: PMC4089503, DOI: 10.5858/arpa.2012-0675-oa.
- Amaya MJ, Oliveira AG, Guimarães ES, Casteluber MC, Carvalho SM, Andrade LM, Pinto MC, Mennone A, Oliveira CA, Resende RR, Menezes GB, Nathanson MH, Leite MF. The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology 2013, 59: 274-283. PMID: 23839970, PMCID: PMC3823683, DOI: 10.1002/hep.26609.
- Nathanson M. Something old, something new. Hepatology 2011, 55: 1-2. DOI: 10.1002/hep.24817.
- Melo F, Guerra M, Andrade V, Fonseca E, Souza-Fagundes E, Menezes G, de Paula A, Nathanson M, Leite M. Mitochondrial Calcium Regulates Liver Regeneration Through Modulation of Apoptosis. Gastroenterology 2011, 140: s-472. DOI: 10.1016/s0016-5085(11)61941-0.
- Reed A, Husain S, Gorelick F, Nathanson M. Low pH Inhibits Gap Junction Communication in the Pancreatic Acinar Cell. Gastroenterology 2011, 140: s-385. DOI: 10.1016/s0016-5085(11)61577-1.
- Kruglov E, Gautam S, Nathanson M. 539 Inositol 1,4,5-Trisphosphate Receptor Type 2 Modulates Bsep Activity in Hepatocytes. Gastroenterology 2010, 138: s-791. DOI: 10.1016/s0016-5085(10)63642-6.
- Guerra M, Cruz L, Kruglov E, Garcia C, Chen J, Nathanson M. 538 Regulation of MRP2 by Calcium Signaling. Gastroenterology 2010, 138: s-790. DOI: 10.1016/s0016-5085(10)63641-4.
- Chaudhuri A, Shah A, Husain S, Gorelick F, Nathanson M. T1935 Low pH Enhances Calcium Signaling in the Pancreatic Acinar Cell. Gastroenterology 2010, 138: s-610. DOI: 10.1016/s0016-5085(10)62812-0.
- 537 The Epidermal Growth Factor Receptor (EGFR) Reaches the Nucleus via a Caveolin-Dependent PathwayRodrigues M, Campos A, Goes A, Nathanson M, Gomes D. 537 The Epidermal Growth Factor Receptor (EGFR) Reaches the Nucleus via a Caveolin-Dependent Pathway. Gastroenterology 2010, 138: s-790. DOI: 10.1016/s0016-5085(10)63640-2.
- Shieh F, Nathanson M, Drumm H, Jamidar P. S1426: High-Definition In-Vivo Probe-Based Confocal Laser Endomicroscopy of the Common Bile Duct. Gastrointestinal Endoscopy 2010, 71: ab158-ab159. DOI: 10.1016/j.gie.2010.03.200.
- Leite M, Andrade V, Nathanson M. Signaling Pathways in Biliary Epithelial Cells. 2009, 25-39. DOI: 10.1007/978-3-642-00150-5_2.
- Leite F, Guerra M, Nathanson M. Ca2+ Signaling in the Liver. 2009, 485-510. DOI: 10.1002/9780470747919.ch32.
- Loeser C, Nathanson M, Jamidar P. Probe-based Laser Confocal Endomicroscopy for the Diagnosis of Biliary Malignancies. The American Journal Of Gastroenterology 2009, 104: s75-s76. DOI: 10.14309/00000434-200910003-00193.
- Andrade V, Jardim C, Melo F, Silva W, Nathanson M, Ortega J, Leite M. 87 Nucleoplasmic Calcium Regulates Proliferation of Hepatocytes Through Legumain and Reticulon4. Gastroenterology 2009, 136: a-792. DOI: 10.1016/s0016-5085(09)63653-2.
- Lagoudakis L, Garcin I, Nahum K, Combettes L, Nathanson M, Tordjmann T. 521 CYTOSOLIC CALCIUM MEDIATES LIVER REGENERATION IN THE RAT. Journal Of Hepatology 2008, 48: s196. DOI: 10.1016/s0168-8278(08)60523-1.
- Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM, Nathanson MH. c-Met Must Translocate to the Nucleus to Initiate Calcium Signals* ♦. Journal Of Biological Chemistry 2007, 283: 4344-4351. PMID: 18073207, PMCID: PMC2825875, DOI: 10.1074/jbc.m706550200.
- Renato P, Correa A, Nathanson M, Wolkoff A, Novikoff P, Thevananther S, Karpen S, Elferink R, Püschel G, Stieger B. Functions of the Liver. 2007, 89-128. DOI: 10.1002/9780470691861.ch2b.
- O'Brien EM, Gomes DA, Sehgal S, Nathanson MH. Hormonal Regulation of Nuclear Permeability* ♦. Journal Of Biological Chemistry 2006, 282: 4210-4217. PMID: 17158097, PMCID: PMC2835336, DOI: 10.1074/jbc.m606300200.
- Marius P, Guerra M, Nathanson M, Ehrlich B, Leite M. Corrigendum to “Calcium release from ryanodine receptors in the nucleoplasmic reticulum” [Cell Calcium 39 (2006) 65–73]. Cell Calcium 2006, 39: 551. DOI: 10.1016/j.ceca.2006.02.001.
- Husain S, Grant W, Kolodecik T, Nathanson M, Gorelick F. DISTINCT CALCIUM SIGNALS REGULATE PANCREATIC ZYMOGEN ACTIVATION. Pancreas 2005, 31: 446-447. DOI: 10.1097/01.mpa.0000193686.75459.3a.
- Nathanson M. Discussion of Basic Science Presentations. Journal Of Clinical Gastroenterology 2005, 39: s210. DOI: 10.1097/01.mcg.0000156106.75129.3f.
- Leite M, Nathanson M. Signaling Pathways in Biliary Epithelial Cells. 2005, 17-26. DOI: 10.1007/3-540-27194-5_2.
- Husain S, Prasad P, Kolodecik T, Nathanson M, Gorelick F. O0093 THE RYANODINE RECEPTOR MODULATES SECRETAGOGUE STIMULATED PANCREATIC ZYMOGEN ACTIVATION. Journal Of Pediatric Gastroenterology And Nutrition 2004, 39: s43-s44. DOI: 10.1097/00005176-200406001-00095.
- Echevarría W, Nathanson M. Gap Junctions in the Liver. 2004, 36-47. DOI: 10.1007/978-1-4419-9034-1_4.
- Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nature Cell Biology 2003, 5: 440-446. PMID: 12717445, PMCID: PMC3572851, DOI: 10.1038/ncb980.
- Guerra M, de Fatima Leite M, Echevarria W, Nathanson M. Ca2+ in the nucleus is independently regulated and has distinct effects on protein kinase C (PKC) in a liver cell line. Gastroenterology 2003, 124: a689. DOI: 10.1016/s0016-5085(03)83484-4.
- Shibao K, Hirata K, Robert M, Nathanson M. Loss of inositol 1,4,5-trisphosphate receptors from cholangiocytes is a final common pathway for cholestasis. Gastroenterology 2003, 124: a692. DOI: 10.1016/s0016-5085(03)83502-3.
- Leite MF, Thrower EC, Echevarria W, Koulen P, Hirata K, Bennett AM, Ehrlich BE, Nathanson MH. Nuclear and cytosolic calcium are regulated independently. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 2975-2980. PMID: 12606721, PMCID: PMC151451, DOI: 10.1073/pnas.0536590100.
- Pusl T, Nathanson M. Chronic Viral Hepatitis: Diagnosis and Therapeutics. Journal Of Clinical Gastroenterology 2002, 34: 496. DOI: 10.1097/00004836-200204000-00033.
- Dranoff J, Masyuk A, Kruglov E, LaRusso N, Nathanson M. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. AJP Gastrointestinal And Liver Physiology 2001, 281: g1059-g1067. PMID: 11557527, DOI: 10.1152/ajpgi.2001.281.4.g1059.
- Pusl T, Nathanson M. Transplantation of the Liver, Third Edition. Journal Of Clinical Gastroenterology 2001, 33: 347-348. DOI: 10.1097/00004836-200110000-00026.
- NATHANSON M, BURGSTAHLER A, MASYUK A, LaRUSSO N. Stimulation of ATP secretion in the liver by therapeutic bile acids. Biochemical Journal 2001, 358: 1-5. DOI: 10.1042/bj3580001.
- Hirata K, Nathanson M. Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver. Gastroenterology 2001, 121: 396-406. PMID: 11487549, DOI: 10.1053/gast.2001.26280.
- Spirlı̀ C, Nathanson M, Fiorotto R, Duner E, Denson L, Sanz J, Di Virgilio F, Okolicsanyi L, Casagrande F, Strazzabosco M. Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium. Gastroenterology 2001, 121: 156-169. PMID: 11438505, DOI: 10.1053/gast.2001.25516.
- HIRATA K, NATHANSON M. Bile duct epithelia regulate biliary bicarbonate excretion in the isolated bivascularly perfused rat liver. Gastroenterology 2001, 120: a357-a357. DOI: 10.1016/s0016-5085(01)81773-x.
- HIRATA K, ONEILL A, LEITE M, NATHANSON M. Regulation of Ca2+ signating in bile duct epithelia by InsP3 receptor isoforms. Gastroenterology 2001, 120: a91-a91. DOI: 10.1016/s0016-5085(01)80448-0.
- Hirata K, O'Neill A, Leite M, Nathanson M. Regulation of Ca2+ signating in bile duct epithelia by InsP3 receptor isoforms. Gastroenterology 2001, 120: a91. DOI: 10.1016/s0016-5085(08)80448-9.
- Hirata K, Nathanson M. Bile duct epithelia regulate biliary bicarbonate excretion in the isolated bivascularly perfused rat liver. Gastroenterology 2001, 120: a357. DOI: 10.1016/s0016-5085(08)81773-8.
- Dranoff J, O'Neill A, Franco A, Cai S, Connolly G, Ballatori N, Boyer J, Nathanson M. A Primitive ATP Receptor from the Little Skate Raja erinacea *. Journal Of Biological Chemistry 2000, 275: 30701-30706. PMID: 10900200, DOI: 10.1074/jbc.m003366200.
- Dranoff J, Nathanson M. It's swell to have ATP in the liver. Journal Of Hepatology 2000, 33: 323-325. PMID: 10952251, DOI: 10.1016/s0168-8278(00)80374-8.
- Leite M, Salgado A, Franco A, Burgstahler A, Nathanson M. CA2+ waves require sequential activation of inositol 1,4,5-trisphosphate receptors, then ryanodine receptors in pancreatic acinar cell. Gastroenterology 2000, 118: a875. DOI: 10.1016/s0016-5085(00)85639-5.
- Dranoff J, O’Neill A, Cai S, Franco A, Connelly G, Ballatori N, Boyer J, Nathanson M. Molecular identification of a primitive P2Y ATP receptor in liver from the little skate Raja erinacea. Gastroenterology 2000, 118: a911. DOI: 10.1016/s0016-5085(00)85777-7.
- Dranoff J, McClure M, Burgstahler A, Denson L, Crawford A, Crawford J, Karpen S, Nathanson M. Short‐term regulation of bile acid uptake by microfilament‐dependent translocation of rat ntcp to the plasma membrane. Hepatology 1999, 30: 223-229. PMID: 10385660, DOI: 10.1002/hep.510300136.
- Dranoff J, Nathanson M. Regulation of bile acid transport: Beyond molecular cloning. Hepatology 1999, 29: 1912-1913. PMID: 10347140, DOI: 10.1002/hep.510290643.
- Nathanson M, Rios–Velez L, Burgstahler A, Mennone A. Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. Gastroenterology 1999, 116: 1176-1183. PMID: 10220510, DOI: 10.1016/s0016-5085(99)70021-1.
- LEITE M, DRANOFF J, Ling G, NATHANSON M. Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells. Biochemical Journal 1999, 337: 305-309. DOI: 10.1042/bj3370305.
- Hagar R, Burgstahler A, Nathanson M, Ehrlich B. Type III InsP3 receptor channel stays open in the presence of increased calcium. Nature 1998, 396: 81-84. PMID: 9817204, PMCID: PMC2825878, DOI: 10.1038/23954.
- Hirata K, Nathanson M, Sears M. Novel paracrine signaling mechanism in the ocular ciliary epithelium. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 8381-8386. PMID: 9653195, PMCID: PMC20984, DOI: 10.1073/pnas.95.14.8381.
- Schmid S, Modlin I, Tang L, Stoch A, Rhee S, Nathanson M, Scheele G, Gorelick F. Telenzepine-sensitive muscarinic receptors on rat pancreatic acinar cells. American Journal Of Physiology 1998, 274: g734-g741. PMID: 9575856, DOI: 10.1152/ajpgi.1998.274.4.g734.
- Burgstahler A, Nathanson M. Coordination of calcium waves among hepatocytes: Teamwork gets the job done. Hepatology 1998, 27: 634-635. PMID: 9462668, DOI: 10.1002/hep.510270244.
- Jeffrey L, BURGSTAHLER A, NATHANSON M. Mechanism of long-range Ca2+ signalling in the nucleus of isolated rat hepatocytes. Biochemical Journal 1997, 326: 491-495. PMID: 9291123, PMCID: PMC1218696, DOI: 10.1042/bj3260491.
- Nathanson M, Fallon M, Burgstahler A, Mennone A, Schlosser S, Gonzalez C, Sáez J. Intercellular Calcium Signaling in Liver. 1997, 469-481. DOI: 10.1007/978-1-4899-1795-9_27.
- Fiarman G, Nathanson M, Brian West A, Deckelbaum L, Kelly L, Kapadia C. Differences in laser-induced autofluorescence between adenomatous and hyperplastic polyps and normal colonic mucosa by confocal microscopy. Digestive Diseases And Sciences 1995, 40: 1261-1268. PMID: 7781444, DOI: 10.1007/bf02065535.
- Nathanson M, Mariwalla K. Characterization and function of ATP receptors on hepatocytes from the little skate Raja erinacea. Gastroenterology 1995, 108: a1132. DOI: 10.1016/0016-5085(95)28828-7.
- Bruck R, Nathanson M, Roelofsen H, Boyer J. Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver. Hepatology 1994, 20: 1032-1040. PMID: 7927205, DOI: 10.1002/hep.1840200436.
- Nathanson M. Cellular and subcellular calcium signaling in gastrointestinal epithelium. Gastroenterology 1994, 106: 1349-1364. PMID: 8174894, DOI: 10.1016/0016-5085(94)90030-2.
- Beuers U, Nathanson M, Boyer J. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993, 104: 604-612. PMID: 8425704, DOI: 10.1016/0016-5085(93)90433-d.
- Rosales O, Isales C, Nathanson M, Sumpio B. Immunocytochemical expression and localization of protein kinase C in bovine aortic endothelial cells. Biochemical And Biophysical Research Communications 1992, 189: 40-46. PMID: 1449492, DOI: 10.1016/0006-291x(92)91522-r.
- Nathanson M, Gautam A, Bruck R, Isales C, Boyer J. Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver. Hepatology 1992, 15: 107-116. PMID: 1727785, DOI: 10.1002/hep.1840150119.
- Nathanson M, Boyer J. Mechanisms and regulation of bile secretion. Hepatology 1991, 14: 551-566. PMID: 1874500, DOI: 10.1002/hep.1840140324.
- Wisnieski J, Nathanson M, Anderson J, Davis A, Alper C, Naff G. Metabolism of C4 and linkage analysis in a kindred with hereditary incomplete C4 deficiency. Arthritis & Rheumatism 1987, 30: 919-926. PMID: 3477232, DOI: 10.1002/art.1780300812.
- Nathanson M, Saidel G, McLaren G. Analysis of iron kinetics: Identifiability, experiment design, and deterministic interpretations of a stochastic model. Mathematical Biosciences 1984, 68: 1-21. DOI: 10.1016/0025-5564(84)90072-5.
- Nathanson M, Hillman R, Georgakis C. Towards an optimal drug-delivery regimen for methotrexate chemotherapy. Applied Mathematics And Computation 1983, 12: 99-117. DOI: 10.1016/0096-3003(83)90002-4.
Departments and Programs
Locations
1
Liver Clinic
Bridgeport Hospital-226 Mill Hill Avenue
226 Mill Hill Avenue
Bridgeport, CT 06610
1 of 2
- Liver ClinicBridgeport Hospital-226 Mill Hill Avenue226 Mill Hill AvenueBridgeport, CT 06610
- Yale Digestive DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510
1
Liver Clinic
Bridgeport Hospital-226 Mill Hill Avenue
226 Mill Hill Avenue
Bridgeport, CT 06610
1 of 2
- Liver ClinicBridgeport Hospital-226 Mill Hill Avenue226 Mill Hill AvenueBridgeport, CT 06610
- Yale Digestive DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510