- Yale New Haven Transplantation CenterDanbury Hospital24 Hospital AvenueDanbury, CT 06810
- Yale Transplant & Immunology ProgramGreenwich Hospital5 Perryridge RdGreenwich, CT 06830
- Yale New Haven Transplantation CenterYale Physicians Building800 Howard Avenue, Fl 4th floorNew Haven, CT 06519
- Yale Transplantation Center; Long Ridge Medical Center260 Long Ridge RoadStamford, CT 06902
Michael Schilsky, MD
Biography
Michael Schilsky, MD, is the medical director of Adult Liver Transplant at Yale-New Haven Transplantation Center. He is an internationally recognized expert in Wilson disease, a rare genetic disorder in which excessive amounts of copper accumulate in the body.
Dr. Schilsky says he was drawn to the study and treatment of Wilson disease because of its complexity, and he is optimistic about the growing promise of new treatments that can help patients with this difficult medical condition. “Wilson disease can be hard to diagnose as it can present with a constellation of symptoms, but once considered we have great tools now to establish the diagnosis and treat this disorder,” he says. “The future is very bright. We hope to have a cure someday, perhaps by genetic therapy. In the meantime, new innovations and medications being tested in clinical trials are truly helping patients.”
An advisor to the Wilson Disease Association, Dr. Schilsky helped write guidelines for the diagnosis and treatment of the disorder for both the American Association for the Study of Liver Disease and the European Association for Liver Disease. Here in the Northeast, Yale is the only Center of Excellence designated by the Wilson Disease Association. We are one of a limited number of sites worldwide to participate in a clinical trial for a promising new therapy for Wilson disease, an oral medication known as WTX101.
Left untreated, Wilson disease can cause advanced liver disease or acute liver failure. Dr. Schilsky specializes in managing these challenging cases, including those caused by other metabolic liver diseases. If a liver transplant is required (these are performed at Yale-New Haven Hospital) Dr. Schilsky cares for patients both before and after the surgery. Dr. Schilsky is also a professor of medicine (digestive diseases) and surgery (transplant and immunology) at Yale School of Medicine.
Titles
- Professor of Medicine
- Medical Director, Adult Liver Transplant at Yale-New Haven Transplantation Center
Education & Training
- FellowAlbert Einstein College of Medicine (1989)
- FellowAlbert Einstein College of Medicine (1987)
- ResidentBronx Municipal Hospital Center/Albert Einstein College of Medicine (1985)
- MDUniversity of Chicago Pritzker School of Medicine (1982)
- BSSUNY at Stonybrook (1978)
Additional Information
- AB of Internal Medicine, Gastroenterology (1987)
- AB of Internal Medicine, Internal Medicine (1985)
- Yale New Haven Hospital (2008 - Present): Pharmacy and Therapeutics Committee
- Yale New Haven Transplantation Center (2007 - Present): Quality Assurance and Performance Improvement
- American Liver Foundation (2007 - Present): Medical Advisory Committee
- Wilson's Disease Association (1999 - Present): Medical Advisory Committee
- Camarata M, Ala A, Coskun A, Deng Y, Embel V, Gonzalez-Peralta R, Maciejewski K, Patel A, Rubman S, To U, Tomlin R, Schilsky M, Zimbrean P. Major Depressive Disorder in an International Multisite Wilson Disease Registry Journal Of The Academy Of Consultation-Liaison Psychiatry 2022, 64: 106-117. PMID: 36521682, DOI: 10.1016/j.jaclp.2022.12.001.
- Weiss K, Schilsky M, Czlonkowska A, Askari F, Ala A, Ferenci P, Ott P, Abdurakhmanov D, Szalay F, Socha P, Shimizu N, Bronstein J, Bega D, Hahn S, Swenson E, Chen Y, Poujois A. O01 Efficacy and safety of ALXN1840 versus standard of care in Wilson disease: primary results from an ongoing phase 3, randomized, controlled, rater-blinded trial 2022, a1-a1. DOI: 10.1136/gutjnl-2022-basl.1.
- Kamlin C, Schilsky M, Ott P, Weiss K, Zuin M, Poujois A, Ala A, D’Hollander K. FRI297 Defining the boundaries for “stability” in Wilson disease patients on maintenance chelation therapy: lessons from the CHELATE trial Journal Of Hepatology 2022, 77: s539. DOI: 10.1016/s0168-8278(22)01402-7.
- Weiss K, Schilsky M, Czlonkowska A, Askari F, Ala A, Ferenci P, Ott P, Abdurakhmanov D, Szalay F, Socha P, Shimizu N, Bronstein J, Bega D, Hahn S, Swenson E, Chen Y, Poujois A. GS001 Efficacy and safety of ALXN1840 versus standard of care in Wilson disease: primary results from an ongoing phase 3, randomized, controlled, rater-blinded trial Journal Of Hepatology 2022, 77: s1. DOI: 10.1016/s0168-8278(22)00428-7.
- Schilsky M, Poujois A, Zuin M, Ott P, Weiss K, Cassiman D, Ala A, Czlonkowska A, Dubois N, Amin N, Kamlin C. OS077 Clinical utility of non-ceruloplasmin copper determined by copper speciation for monitoring Wilson disease therapy: comparative data analysis with 24-hour urinary copper excretion from the CHELATE trial Journal Of Hepatology 2022, 77: s61-s62. DOI: 10.1016/s0168-8278(22)00524-4.
- Poujois A, Giovanni Z, Anna C, Obadia M, Henry A, Weiss K, Schilsky M. Résultats à un an de l’étude chelate : comparaison de la trientine tétrahydrochloride à la D-Pénicillamine chez des patients stables atteints de la maladie de Wilson Revue Neurologique 2022, 178: s47. DOI: 10.1016/j.neurol.2022.02.226.
- Zuin M, Czlonkowska A, Cassiman D, Poujois A, Ott P, Dubois N, Weiss K, Monico S, Battezzati P, Carnevali G, Schilsky M, Investigators C. Trientine tetrahydrochloride versus d-Penicillamine for the management of patients with Wilson Disease: results from the CHELATE trial a year after randomisation Digestive And Liver Disease 2022, 54: s2. DOI: 10.1016/j.dld.2022.01.007.
- Stravitz RT, Fontana RJ, Meinzer C, Durkalski‐Mauldin V, Hanje AJ, Olson J, Koch D, Hamid B, Schilsky M, McGuire B, Ganger D, Liou I, Karvellas CJ, Rule JA, Lisman T, Clasen K, Reuben A, Cripps M, Lee WM, Group A. Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure Hepatology 2021, 74: 937-949. PMID: 33636020, DOI: 10.1002/hep.31767.
- Moini M, To U, Schilsky M. Recent advances in Wilson disease Translational Gastroenterology And Hepatology 2021, 6: 21-21. DOI: 10.21037/tgh-2019-rld-10.
- Camarata M, Ala A, Maciejewski K, To U, Zimbrean P, Rubman S, Coskun A, Patel A, Wadhwa A, Apdik T, Tomlin R, Deng Y, Gonzalez-Peralta R, Schilsky M. P12 Effect of liver disease, neurological disease and mental health issues on quality of life in patients with wilson disease Gut 2020, 69: a13-a13. DOI: 10.1136/gutjnl-2020-basl.23.
- Camarata M, Ala A, Maciejewski K, To U, Zimbrean P, Rubman S, Patel A, Wadhwa A, Coskun A, Apdik T, Tomlin R, Deng Y, Schilsky M. P13 Major depressive disorder in patients with wilson’s disease: relationship with liver disease, neurological disease and quality of life Gut 2020, 69: a13-a13. DOI: 10.1136/gutjnl-2020-basl.24.
- Camarata M, Ala A, To U, Zimbrean P, Rubman S, Patel A, Wadhwa A, Maciejewski K, Song X, Deng Y, Tomlin R, Apdik T, Coskun A, Schilsky M. FRI303 Major depressive disorder in patients with Wilson’s disease: relationship with liver disease, neurological disease and quality of life Journal Of Hepatology 2020, 73: s550-s551. DOI: 10.1016/s0168-8278(20)31573-7.
- Zimbrean P, Rubman S, Maciejewski K, Coskun, Nalamada K, Camarata M, Tomlin R, Patel A, To U, Ala A, Gonzalez-Peralta R, Deng Y, Schilsky M. 257 Bipolar disorder in patients with Wilson disease Journal Of Psychosomatic Research 2020, 133: 110055. DOI: 10.1016/j.jpsychores.2020.110055.
- Schilsky M, Mistry P. Inherited diseases of copper metabolism: Wilson’s disease and Menkes’ disease 2020, c12.7.2-c12.7.2.s26. DOI: 10.1093/med/9780198746690.003.0234.
- Zimbrean P, Gold S, Nalamada K, Camarata M, Tomlin R, Patel A, Vives-Rodrigues A, Ekong U, Bramford N, Valentino P, To U, Deng Y, Song X, Ala A, Schilsky M. Major depressive disorder in patients with Wilson disease Journal Of Psychosomatic Research 2019, 121: 148. DOI: 10.1016/j.jpsychores.2019.03.145.
- Camarata M, Ala A, Schilsky M. FRI-425-Maintenance therapy for Wilson disease with zinc: A comparison between zinc acetate and alternative zinc salts Journal Of Hepatology 2019, 70: e581. DOI: 10.1016/s0618-8278(19)31162-4.
- Kelly C, Ala A, Schilsky M. Wilson's Disease 2019, 554-573. DOI: 10.1002/9781119211419.ch37.
- Schilsky M. Chapter 39 New Treatment Modalities in Wilson Disease 2019, 399-405. DOI: 10.1016/b978-0-12-810532-0.00039-2.
- Camarata M, Weiss K, Schilsky M. Chapter 15 General Considerations and the Need for Liver Transplantation 2019, 173-182. DOI: 10.1016/b978-0-12-811077-5.00015-3.
- Camarata M, Weiss K, Schilsky M. Chapter 23 Special Treatment Considerations for Wilson Disease 2019, 235-245. DOI: 10.1016/b978-0-12-811077-5.00023-2.
- Pericleous M, Kelly C, Ala A, Schilsky M. The Epidemiology of Rare Hereditary Metabolic Liver Diseases 2018, 307-330. DOI: 10.1007/978-3-319-94355-8_17.
- To U, Schilsky M. Introduction to Copper Metabolism and Wilson Disease 2018, 1-16. DOI: 10.1007/978-3-319-91527-2_1.
- Miloh T, Schilsky M. Monitoring Treatment of Wilson Disease 2018, 143-159. DOI: 10.1007/978-3-319-91527-2_8.
- Camarata M, Schilsky M. Wilson Disease: Special Circumstances 2018, 175-181. DOI: 10.1007/978-3-319-91527-2_10.
- Miloh T, Schilsky M. Liver Transplantation for Wilson Disease 2018, 183-202. DOI: 10.1007/978-3-319-91527-2_11.
- Kelly C, Pericleous M, Schilsky M. Treatment Options for Wilson Disease 2018, 45-61. DOI: 10.1007/978-3-319-91527-2_3.
- Camarata M, Schilsky M. Treating Other Symptoms of Wilson Disease: The Liver 2018, 87-106. DOI: 10.1007/978-3-319-91527-2_5.
- Pericleous M, Kelly C, Schilsky M. Diagnosis Confirmation and Screening of Wilson Disease 2018, 17-44. DOI: 10.1007/978-3-319-91527-2_2.
- Graper M, Schilsky M. Partnering for Care of Wilson Disease 2018, 203-212. DOI: 10.1007/978-3-319-91527-2_12.
- Weiss K, Askari F, Ferenci P, Ala A, Czlonkowska A, Nicholl D, Bronstein J, Bega D, Schilsky M. Posters Thursday, 12 April 2018 Journal Of Hepatology 2018, 68: s105-s364. DOI: 10.1016/s0168-8278(18)30428-8.
- Schilsky M. Chapter 19 Wilson Disease and Related Disorders 2018, 253-268. DOI: 10.1016/b978-0-323-47874-8.00019-5.
- Camarata M, Ala A, Schilsky M. Update on Wilson disease: focus on WTX-101 Drugs Of The Future 2018, 43: 501. DOI: 10.1358/dof.2018.043.07.2819432.
- Schilsky M, Ala A. Wilson Disease 2017, 799-819. DOI: 10.1002/9781119251316.ch29.
- Randesi M, Levran O, da Rosa J, Hankins J, Rule J, Kreek M, Lee W, Group A, Reuben A, Fontana R, Davern T, McGuire B, Stravitz R, Durkalski V, Liou I, Fix O, Schilsky M, Ganger D, Chung R, Koch D, Reddy K, Rossaro L. Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury Cellular And Molecular Gastroenterology And Hepatology 2017, 3: 500-505. PMID: 28462386, PMCID: PMC5404026, DOI: 10.1016/j.jcmgh.2017.01.008.
- Weiss K, Askari F, Ferenci P, Ala A, Czlonkowska A, Nicholl D, Bronstein J, Bega D, Schilsky M. GS-016 WTX101 in patients newly diagnosed with Wilson disease: final results of a global, prospective phase 2 trial Journal Of Hepatology 2017, 66: s88. DOI: 10.1016/s0168-8278(17)30440-3.
- Weiss K, Ala A, Askari F, Bega D, Bronstein J, Czlonkowska A, Ferenci P, Nicholl D, Schilsky M. PS020 An Ongoing Phase 2, Multi-Centre, Open-Label, Study of WTX101 in Newly Diagnosed Wilson Disease Patients – Early Observations Journal Of Hepatology 2016, 64: s145-s146. DOI: 10.1016/s0168-8278(16)00033-7.
- Do A, Lim J, Liapakis A, Babas G, Caldwell C, Fortune B, Emre S, Kulkarni S, Lempit S, Mistry P, Mulligan D, Rodriguez-Davalos M, Schilsky M, Tichy E, Yoo P, Jakab S. Tu1044 Sofosbuvir-Based Interferon-Free Regimens for Hepatitis C Infection in Patients With Compensated and Decompensated Cirrhosis: Interim Analysis of a Prospective Observational Cohort Gastroenterology 2015, 148: s-1094-s-1095. DOI: 10.1016/s0016-5085(15)33733-1.
- Weiss K, Askari F, Ferenci P, Czlonkowska A, Bronstein J, Schilsky M, Clark D, Hansson J. P1313 : WTX101–201 : Phase 2 study of bis-choline tetrathiomolybdate in newly diagnosed wilson disease patients Journal Of Hepatology 2015, 62: s847. DOI: 10.1016/s0168-8278(15)31492-6.
- Njei B, Schilsky M, Ditah I, Taddei T. Su1011 Should Liver Transplantation Be Reconsidered in Patients With Intrahepatic Cholangiocarcinoma? A Systematic Review and Meta-Regression Analysis of Epidemiologic Evidence Gastroenterology 2015, 148: s-1036. DOI: 10.1016/s0016-5085(15)33541-1.
- Ala A, Aliu E, Schilsky ML. Prospective Pilot Study of a Single Daily Dosage of Trientine for the Treatment of Wilson Disease Digestive Diseases And Sciences 2015, 60: 1433-1439. PMID: 25605552, PMCID: PMC4427615, DOI: 10.1007/s10620-014-3495-6.
- Karvellas CJ, Stravitz R, Battenhouse H, Lee WM, Schilsky ML, Group F. Therapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis Liver Transplantation 2014, 21: 4-12. PMID: 25308108, PMCID: PMC4939841, DOI: 10.1002/lt.24021.
- Kim A, Schilsky M. Radiology in Transplant Current Transplantation Reports 2014, 1: 238-245. DOI: 10.1007/s40472-014-0034-5.
- Thiessen C, Patrón‐Lozano R, Schilsky M, Rodríguez‐Dávalos M. Right Homonymous Hemianopsia and Seizures in a Liver Transplant Recipient American Journal Of Transplantation 2014, 14: 2427-2429. PMID: 25231067, DOI: 10.1111/ajt.12870.
- Kaler S, Schilsky M. In Memoriam: H. Ascher Sellner, M.D. Annals Of The New York Academy Of Sciences 2014, 1314: iv-iv. DOI: 10.1111/nyas.12449.
- Karvellas C, Stravitz R, Battenhouse H, Durkalski V, Lee W, Schilsky M. P319 HYPOTHERMIA IN ACUTE LIVER FAILURE: A MULTI-CENTRE RETROSPECTIVE COHORT ANALYSIS (IT'S ALRIGHT TO BE COOL) Journal Of Hepatology 2014, 60: s173. DOI: 10.1016/s0168-8278(14)60481-5.
- Karvellas C, Stravitz R, Battenhouse H, Durkalski V, Lee W, Schilsky M. A multicenter retrospective cohort analysis of therapeutic hypothermia in acute liver failure Critical Care 2014, 18: p200. PMCID: PMC4068622, DOI: 10.1186/cc13390.
- McGinniss J, Marshall P, Schilsky M, Honiden S. 730 Critical Care Medicine 2013, 41: a180-a181. DOI: 10.1097/01.ccm.0000439968.28678.d4.
- Russ K, Khan A, James L, Schilsky M, Fix O, Lee W, McGuire B. Acute Liver and Multi-organ Failure Secondary to Intentional Iron Overdose The American Journal Of Gastroenterology 2013, 108: s324. DOI: 10.14309/00000434-201310001-01086.
- Chung R, Gordon F, Curry M, Schiano T, Emre S, Corey K, Markmann J, Hertl M, Pomposelli J, Pomfret E, Florman S, Schilsky M, Broering T, Finberg R, Szabo G, Zamore P, Khettry U, Babcock G, Ambrosino D, Leav B, Leney M, Smith H, Molrine D. Human Monoclonal Antibody MBL‐HCV1 Delays HCV Viral Rebound Following Liver Transplantation: A Randomized Controlled Study American Journal Of Transplantation 2013, 13: 1047-1054. PMID: 23356386, PMCID: PMC3618536, DOI: 10.1111/ajt.12083.
- European Association for Study of Liver. J Hepatol. 56:671-685
- Schilsky M, Tavill A. Wilson Disease 2011, 803-824. DOI: 10.1002/9781119950509.ch29.
- Rosencrantz1 2, Schilsky2 3. Wilson Disease: Pathogenesis and Clinical Considerations in Diagnosis and Treatment Seminars In Liver Disease 2011, 31: 245-259. PMID: 21901655, DOI: 10.1055/s-0031-1286056.
- Ala1 A, Schilsky2 M. Genetic Modifiers of Liver Injury in Hereditary Liver Disease Seminars In Liver Disease 2011, 31: 208-214. PMID: 21538285, DOI: 10.1055/s-0031-1276648.
- Schilsky M, Mitchell K. Wilson’s Disease 2010, 5: 655-663. DOI: 10.1007/978-1-4419-7107-4_43.
- Schilsky M, Mistry P. Inherited diseases of copper metabolism: Wilson’s disease and Menkes’ disease 2010, 1688-1693. DOI: 10.1093/med/9780199204854.003.120702.
- Schilsky M, Thiele D. Copper Metabolism and the Liver 2009, 221-233. DOI: 10.1002/9780470747919.ch15.
- Wong R, Gish R, Schilsky M, Frenette C. T1002 Clinical Epidemiology of Wilson Disease in Patients with Concurrent Liver Disease Gastroenterology 2009, 136: a-844. DOI: 10.1016/s0016-5085(09)63889-0.
- Arnon R, Annunziato R, Schilsky M, Miloh T, Suchy F, Iyer K, Kerkar N. M1731 Wilson Disease and Outcomes After Liver Transplantation Gastroenterology 2009, 136: a-420. DOI: 10.1016/s0016-5085(09)61931-4.
- Schilsky M, Lee W, Wiands F. Reply: Hepatology 2009, 49: 1784-1784. DOI: 10.1002/hep.22954.
- Schilsky ML, Honiden S, Arnott L, Emre S. ICU Management of Acute Liver Failure Clinics In Chest Medicine 2009, 30: 71-87. PMID: 19186281, DOI: 10.1016/j.ccm.2008.10.001.
- Schilsky M, Mistry P. Chapter 42 Wilson Disease and the Kidney 2009, 709-713. DOI: 10.1016/b978-0-12-449851-8.00042-5.
- Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH, Fontana RJ, Lee WM, Schilsky ML, Groups P. Screening for Wilson disease in acute liver failure: A comparison of currently available diagnostic tests Hepatology 2008, 48: 1167-1174. PMID: 18798336, PMCID: PMC4881751, DOI: 10.1002/hep.22446.
- Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: An update Hepatology 2008, 47: 2089-2111. PMID: 18506894, DOI: 10.1002/hep.22261.
- Brewer G, Askari F, Lorincz M, Carlson M, Schilsky M, Kluin K, Hedera P, Moretti P, Fink J, Tankanow R, Dick R, Sitterly J. Tetrathiomolybdate versus Trientine in the Initial Treatment of Neurologic Wilson's Disease 2008, 153-166. DOI: 10.1017/cbo9780511666971.010.
- Brewer G, Askari F, Lorincz M, Carlson M, Schilsky M, Kluin K, Hedera P, Moretti P, Fink J, Tankanow R, Dick R, Sitterly J. Tetrathiomolybdate versus Trientine in the Initial Treatment of Neurologic Wilson's Disease Progress In Neurotherapeutics And Neuropsychopharmacology 2007, 3 DOI: 10.1017/s1748232107000043.
- Schilsky M, Kinkhabwala M, Emond J. Chapter 38 The Transplant Operation: What the Hepatologist Should Know 2006, 605-620. DOI: 10.1016/b978-0-323-03675-7.50042-1.
- KOWDLEY K, BRANDHAGEN D, GISH R, BASS N, WEINSTEIN J, SCHILSKY M, FONTANA R, MCCASHLAND T, COTLER S, BACON B. Survival After Liver Transplantation in Patients With Hepatic Iron Overload: The National Hemochromatosis Transplant Registry Gastroenterology 2005, 129: 494-503. DOI: 10.1016/j.gastro.2005.05.004.
- Schilsky M. Wilson's Disease 2004, 643-647. DOI: 10.1016/b0-12-386860-2/00731-0.
- Roberts E, Schilsky M. Corrections: A practice guideline on Wilson disease Hepatology 2003, 38: 536-536. DOI: 10.1002/hep.510380241.
- Korman J, Schiodt F, Balko J, Lee W, Schilsky M, Group A. Elevation of serum ferritin and survival of patients with acute liver failure Gastroenterology 2003, 124: a756. DOI: 10.1016/s0016-5085(03)83818-0.
- Joseph B, Bhargava K, Kandimalla J, Malhi H, Schilsky M, Palestro C, Jain D, Gupta S. Mechanism of sestamibi retention and clearance from myocardium and other organs Journal Of The American College Of Cardiology 2003, 41: 444. DOI: 10.1016/s0735-1097(03)81349-9.
- Branch A, Walewski J, Gutierrez J, Fernandez E, Im G, Dieterich D, Schiano T, Sigal S, Schilsky M, Schwartz M, Kyrk C, Muerhoff A, Leary T, Stewart J, Dawson G, Desai S. 640 HCV alternate reading frame proteins (ARFPS) may be virulence factors that help the virus survive adverse conditions Hepatology 2003, 38: 468-469. DOI: 10.1016/s0270-9139(03)80682-1.
- Wai C, Fontana R, Schilsky M, McCashland T, Han S, Polson J, Hussain M, Lee W, Lok A. 815 Molecular epidemiology of hepatitis B virus-related acute liver failure in the United States: a multicenter case control study Hepatology 2003, 38: 555. DOI: 10.1016/s0270-9139(03)80857-1.
- Schilsky M. The irony of treating Wilson's disease The American Journal Of Gastroenterology 2001, 96: ajg2001764. PMID: 11721750, DOI: 10.1111/j.1572-0241.2001.05254.x.
- Emre S, Atillasoy E, Ozdemir S, Schilsky M, Varma C, Thung S, Sternlieb I, Guy S, Sheiner P, Schwartz M, Miller C. ORTHOTOPIC LIVER TRANSPLANTATION FOR WILSON’S DISEASE Transplantation 2001, 72: 1232-1236. PMID: 11602847, DOI: 10.1097/00007890-200110150-00008.
- Schilsky M, Mistry P. Metabolic liver disease Current Opinion In Gastroenterology 2001, 17: 221-231. PMID: 17031163, DOI: 10.1097/00001574-200105000-00005.
- Irani A, Malhi H, Slehria S, Gorla G, Volenberg I, Schilsky M, Gupta S. Correction of Liver Disease Following Transplantation of Normal Rat Hepatocytes into Long–Evans Cinnamon Rats Modeling Wilson's Disease Molecular Therapy 2001, 3: 302-309. PMID: 11273771, DOI: 10.1006/mthe.2001.0271.
- Schilsky M. Treatment of Wilson’s disease: What are the relative roles of penicillamine, trientine, and zinc supplementation? Current Colorectal Cancer Reports 2001, 3: 54-59. PMID: 11177695, DOI: 10.1007/s11894-001-0041-4.
- Schilsky M, Mistry P. Inherited metabolic disease Current Opinion In Gastroenterology 2000, 16: 219-230. PMID: 17023879, DOI: 10.1097/00001574-200005000-00004.
- Schilsky M, Irani A, Gorla G, Volenberg I, Gupta S. Biliary copper excretion capacity in intact animals: Correlation between ATP7B function, hepatic mass, and biliary copper excretion Journal Of Biochemical And Molecular Toxicology 2000, 14: 210-214. PMID: 10789499, DOI: 10.1002/(sici)1099-0461(2000)14:4<210::aid-jbt5>3.0.co;2-g.
- Schilsky M. Inherited metabolic disease Current Opinion In Gastroenterology 1999, 15: 200-207. PMID: 17023946, DOI: 10.1097/00001574-199905000-00004.
- Tavill A, Schilsky M. Wilson’s disease Current Treatment Options In Gastroenterology 1999, 2: 68-71. PMID: 11096575, DOI: 10.1007/s11938-999-0021-6.
- Rajvanshi P, Liu D, Ott M, Gagandeep S, Schilsky M, Gupta S. Fractionation of Rat Hepatocyte Subpopulations with Varying Metabolic Potential, Proliferative Capacity, and Retroviral Gene Transfer Efficiency Experimental Cell Research 1998, 244: 405-419. PMID: 9806791, DOI: 10.1006/excr.1998.4223.
- Schilsky M, Stockert R, Kesner A, Gorla G, Gagliardi G, Terada K, Miura N, Czaja M. Copper resistant human hepatoblastoma mutant cell lines without metallothionein induction overexpress ATP7B Hepatology 1998, 28: 1347-1356. PMID: 9794921, DOI: 10.1002/hep.510280525.
- Terada K, Schilsky M, Miura N, Sugiyama T. ATP7B (WND) protein The International Journal Of Biochemistry & Cell Biology 1998, 30: 1063-1067. PMID: 9785470, DOI: 10.1016/s1357-2725(98)00073-9.
- Schilsky M. Inherited metabolic disease Current Opinion In Gastroenterology 1998, 14: 200-207. DOI: 10.1097/00001574-199805000-00004.
- Meerson N, Delautier D, Durand‐Schneider A, Moreau A, Schilsky M, Sternlieb I, Feldmann G, Maurice M. Identification of B10, an alkaline phosphodiesterase of the apical plasma membrane of hepatocytes and biliary cells, in rat serum: Increased levels following bile duct ligation and during the development of cholangiocarcinoma Hepatology 1998, 27: 563-568. PMID: 9462658, DOI: 10.1002/hep.510270234.
- Schilsky M, Sternlieb I. Wilson’s Disease 1998, 285-292. DOI: 10.1007/978-1-4612-1808-1_21.
- Schilsky M, Sternlieb I. Genetic Hemochromatosis 1998, 241-247. DOI: 10.1007/978-1-4612-1808-1_18.
- Schilsky M. Inherited metabolic disease Current Opinion In Gastroenterology 1997, 13: 194-198. DOI: 10.1097/00001574-199705000-00004.
- Sternlieb I, Quintana N, Volenberg I, Schilsky M. An array of mitochondrial alterations in the hepatocytes of long‐evans cinnamon rats Hepatology 1995, 22: 1782-1787. PMID: 7489989, DOI: 10.1002/hep.1840220626.
- Sternlieb I, Quintana N, Volenberg I, Schilsky M. An array of mitochondrial alterations in the hepatocytes of Long-Evans Cinnamon rats Hepatology 1995, 22: 1782-1787. DOI: 10.1016/0270-9139(95)90206-6.
- Schilsky M. In vitro modeling of liver membrane copper transport Hepatology 1995, 22: 1340-1342. PMID: 7557893, DOI: 10.1002/hep.1840220449.
- Schilsky M. In Vitro modeling of liver membrane copper transports Dijkstra M, Veld GI, van den Berg GJ, Muller M, Kuipers F, Vonk RJ. J. Clin Invest 1995; 95: 412–416 Hepatology 1995, 22: 1340-1342. DOI: 10.1016/0270-9139(95)90651-7.
- Terada K, Manchikalapudi P, Noiva R, Jauregui H, Stockert R, Schilsky M. Secretion, Surface Localization, Turnover, and Steady State Expression of Protein Disulfide Isomerase in Rat Hepatocytes (∗) Journal Of Biological Chemistry 1995, 270: 20410-20416. PMID: 7657616, DOI: 10.1074/jbc.270.35.20410.
- Fox I, Chowdhury N, Gupta S, Kondapalli R, Schilsky M, Stockert R, Chowdhury J. Conditional immortalization of gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin‐UDP‐glucuronosyltransferase gene transfer Hepatology 1995, 21: 837-846. PMID: 7875682, DOI: 10.1002/hep.1840210334.
- Fox I, Chowdhury N, Gupta S, Kondapalli R, Schilsky M, Stockert R, Chowdhury J. Conditional immortalization of gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin-UDP-glucuronosyltransferase gene transfer Hepatology 1995, 21: 837-846. DOI: 10.1016/0270-9139(95)90539-1.
- Schilsky M. Identification of the Wilson's disease gene: Clues for disease pathogenesis and the potential for molecular diagnosis Hepatology 1994, 20: 529-533. PMID: 8045514, DOI: 10.1002/hep.1840200235.
- Schilsky M, Scheinberg I, Sternlieb I. Liver transplantation for Wilson's disease: Indications and outcome Hepatology 1994, 19: 583-587. PMID: 8119682, DOI: 10.1002/hep.1840190307.
- Schilsky M, Shafritz D. Biochemistry and molecular biology of the liver Current Opinion In Gastroenterology 1992, 8: 418-425. DOI: 10.1097/00001574-199206000-00009.
- Schilsky M, Scheinberg I, Sternlieb I. Prognosis of Wilsonian chronic active hepatitis Gastroenterology 1991, 100: 762-767. PMID: 1993498, DOI: 10.1016/0016-5085(91)80023-3.
- Scheinberg I, Sternlieb I, Schilsky M, Stockert R. PENICILLAMINE MAY DETOXIFY COPPER IN WILSON'S DISEASE The Lancet 1987, 330: 95. PMID: 2885586, DOI: 10.1016/s0140-6736(87)92753-x.
Biography
Michael Schilsky, MD, is the medical director of Adult Liver Transplant at Yale-New Haven Transplantation Center. He is an internationally recognized expert in Wilson disease, a rare genetic disorder in which excessive amounts of copper accumulate in the body.
Dr. Schilsky says he was drawn to the study and treatment of Wilson disease because of its complexity, and he is optimistic about the growing promise of new treatments that can help patients with this difficult medical condition. “Wilson disease can be hard to diagnose as it can present with a constellation of symptoms, but once considered we have great tools now to establish the diagnosis and treat this disorder,” he says. “The future is very bright. We hope to have a cure someday, perhaps by genetic therapy. In the meantime, new innovations and medications being tested in clinical trials are truly helping patients.”
An advisor to the Wilson Disease Association, Dr. Schilsky helped write guidelines for the diagnosis and treatment of the disorder for both the American Association for the Study of Liver Disease and the European Association for Liver Disease. Here in the Northeast, Yale is the only Center of Excellence designated by the Wilson Disease Association. We are one of a limited number of sites worldwide to participate in a clinical trial for a promising new therapy for Wilson disease, an oral medication known as WTX101.
Left untreated, Wilson disease can cause advanced liver disease or acute liver failure. Dr. Schilsky specializes in managing these challenging cases, including those caused by other metabolic liver diseases. If a liver transplant is required (these are performed at Yale-New Haven Hospital) Dr. Schilsky cares for patients both before and after the surgery. Dr. Schilsky is also a professor of medicine (digestive diseases) and surgery (transplant and immunology) at Yale School of Medicine.
Titles
- Professor of Medicine
- Medical Director, Adult Liver Transplant at Yale-New Haven Transplantation Center
Education & Training
- FellowAlbert Einstein College of Medicine (1989)
- FellowAlbert Einstein College of Medicine (1987)
- ResidentBronx Municipal Hospital Center/Albert Einstein College of Medicine (1985)
- MDUniversity of Chicago Pritzker School of Medicine (1982)
- BSSUNY at Stonybrook (1978)
Additional Information
- AB of Internal Medicine, Gastroenterology (1987)
- AB of Internal Medicine, Internal Medicine (1985)
- Yale New Haven Hospital (2008 - Present): Pharmacy and Therapeutics Committee
- Yale New Haven Transplantation Center (2007 - Present): Quality Assurance and Performance Improvement
- American Liver Foundation (2007 - Present): Medical Advisory Committee
- Wilson's Disease Association (1999 - Present): Medical Advisory Committee
- Camarata M, Ala A, Coskun A, Deng Y, Embel V, Gonzalez-Peralta R, Maciejewski K, Patel A, Rubman S, To U, Tomlin R, Schilsky M, Zimbrean P. Major Depressive Disorder in an International Multisite Wilson Disease Registry Journal Of The Academy Of Consultation-Liaison Psychiatry 2022, 64: 106-117. PMID: 36521682, DOI: 10.1016/j.jaclp.2022.12.001.
- Weiss K, Schilsky M, Czlonkowska A, Askari F, Ala A, Ferenci P, Ott P, Abdurakhmanov D, Szalay F, Socha P, Shimizu N, Bronstein J, Bega D, Hahn S, Swenson E, Chen Y, Poujois A. O01 Efficacy and safety of ALXN1840 versus standard of care in Wilson disease: primary results from an ongoing phase 3, randomized, controlled, rater-blinded trial 2022, a1-a1. DOI: 10.1136/gutjnl-2022-basl.1.
- Kamlin C, Schilsky M, Ott P, Weiss K, Zuin M, Poujois A, Ala A, D’Hollander K. FRI297 Defining the boundaries for “stability” in Wilson disease patients on maintenance chelation therapy: lessons from the CHELATE trial Journal Of Hepatology 2022, 77: s539. DOI: 10.1016/s0168-8278(22)01402-7.
- Weiss K, Schilsky M, Czlonkowska A, Askari F, Ala A, Ferenci P, Ott P, Abdurakhmanov D, Szalay F, Socha P, Shimizu N, Bronstein J, Bega D, Hahn S, Swenson E, Chen Y, Poujois A. GS001 Efficacy and safety of ALXN1840 versus standard of care in Wilson disease: primary results from an ongoing phase 3, randomized, controlled, rater-blinded trial Journal Of Hepatology 2022, 77: s1. DOI: 10.1016/s0168-8278(22)00428-7.
- Schilsky M, Poujois A, Zuin M, Ott P, Weiss K, Cassiman D, Ala A, Czlonkowska A, Dubois N, Amin N, Kamlin C. OS077 Clinical utility of non-ceruloplasmin copper determined by copper speciation for monitoring Wilson disease therapy: comparative data analysis with 24-hour urinary copper excretion from the CHELATE trial Journal Of Hepatology 2022, 77: s61-s62. DOI: 10.1016/s0168-8278(22)00524-4.
- Poujois A, Giovanni Z, Anna C, Obadia M, Henry A, Weiss K, Schilsky M. Résultats à un an de l’étude chelate : comparaison de la trientine tétrahydrochloride à la D-Pénicillamine chez des patients stables atteints de la maladie de Wilson Revue Neurologique 2022, 178: s47. DOI: 10.1016/j.neurol.2022.02.226.
- Zuin M, Czlonkowska A, Cassiman D, Poujois A, Ott P, Dubois N, Weiss K, Monico S, Battezzati P, Carnevali G, Schilsky M, Investigators C. Trientine tetrahydrochloride versus d-Penicillamine for the management of patients with Wilson Disease: results from the CHELATE trial a year after randomisation Digestive And Liver Disease 2022, 54: s2. DOI: 10.1016/j.dld.2022.01.007.
- Stravitz RT, Fontana RJ, Meinzer C, Durkalski‐Mauldin V, Hanje AJ, Olson J, Koch D, Hamid B, Schilsky M, McGuire B, Ganger D, Liou I, Karvellas CJ, Rule JA, Lisman T, Clasen K, Reuben A, Cripps M, Lee WM, Group A. Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure Hepatology 2021, 74: 937-949. PMID: 33636020, DOI: 10.1002/hep.31767.
- Moini M, To U, Schilsky M. Recent advances in Wilson disease Translational Gastroenterology And Hepatology 2021, 6: 21-21. DOI: 10.21037/tgh-2019-rld-10.
- Camarata M, Ala A, Maciejewski K, To U, Zimbrean P, Rubman S, Coskun A, Patel A, Wadhwa A, Apdik T, Tomlin R, Deng Y, Gonzalez-Peralta R, Schilsky M. P12 Effect of liver disease, neurological disease and mental health issues on quality of life in patients with wilson disease Gut 2020, 69: a13-a13. DOI: 10.1136/gutjnl-2020-basl.23.
- Camarata M, Ala A, Maciejewski K, To U, Zimbrean P, Rubman S, Patel A, Wadhwa A, Coskun A, Apdik T, Tomlin R, Deng Y, Schilsky M. P13 Major depressive disorder in patients with wilson’s disease: relationship with liver disease, neurological disease and quality of life Gut 2020, 69: a13-a13. DOI: 10.1136/gutjnl-2020-basl.24.
- Camarata M, Ala A, To U, Zimbrean P, Rubman S, Patel A, Wadhwa A, Maciejewski K, Song X, Deng Y, Tomlin R, Apdik T, Coskun A, Schilsky M. FRI303 Major depressive disorder in patients with Wilson’s disease: relationship with liver disease, neurological disease and quality of life Journal Of Hepatology 2020, 73: s550-s551. DOI: 10.1016/s0168-8278(20)31573-7.
- Zimbrean P, Rubman S, Maciejewski K, Coskun, Nalamada K, Camarata M, Tomlin R, Patel A, To U, Ala A, Gonzalez-Peralta R, Deng Y, Schilsky M. 257 Bipolar disorder in patients with Wilson disease Journal Of Psychosomatic Research 2020, 133: 110055. DOI: 10.1016/j.jpsychores.2020.110055.
- Schilsky M, Mistry P. Inherited diseases of copper metabolism: Wilson’s disease and Menkes’ disease 2020, c12.7.2-c12.7.2.s26. DOI: 10.1093/med/9780198746690.003.0234.
- Zimbrean P, Gold S, Nalamada K, Camarata M, Tomlin R, Patel A, Vives-Rodrigues A, Ekong U, Bramford N, Valentino P, To U, Deng Y, Song X, Ala A, Schilsky M. Major depressive disorder in patients with Wilson disease Journal Of Psychosomatic Research 2019, 121: 148. DOI: 10.1016/j.jpsychores.2019.03.145.
- Camarata M, Ala A, Schilsky M. FRI-425-Maintenance therapy for Wilson disease with zinc: A comparison between zinc acetate and alternative zinc salts Journal Of Hepatology 2019, 70: e581. DOI: 10.1016/s0618-8278(19)31162-4.
- Kelly C, Ala A, Schilsky M. Wilson's Disease 2019, 554-573. DOI: 10.1002/9781119211419.ch37.
- Schilsky M. Chapter 39 New Treatment Modalities in Wilson Disease 2019, 399-405. DOI: 10.1016/b978-0-12-810532-0.00039-2.
- Camarata M, Weiss K, Schilsky M. Chapter 15 General Considerations and the Need for Liver Transplantation 2019, 173-182. DOI: 10.1016/b978-0-12-811077-5.00015-3.
- Camarata M, Weiss K, Schilsky M. Chapter 23 Special Treatment Considerations for Wilson Disease 2019, 235-245. DOI: 10.1016/b978-0-12-811077-5.00023-2.
- Pericleous M, Kelly C, Ala A, Schilsky M. The Epidemiology of Rare Hereditary Metabolic Liver Diseases 2018, 307-330. DOI: 10.1007/978-3-319-94355-8_17.
- To U, Schilsky M. Introduction to Copper Metabolism and Wilson Disease 2018, 1-16. DOI: 10.1007/978-3-319-91527-2_1.
- Miloh T, Schilsky M. Monitoring Treatment of Wilson Disease 2018, 143-159. DOI: 10.1007/978-3-319-91527-2_8.
- Camarata M, Schilsky M. Wilson Disease: Special Circumstances 2018, 175-181. DOI: 10.1007/978-3-319-91527-2_10.
- Miloh T, Schilsky M. Liver Transplantation for Wilson Disease 2018, 183-202. DOI: 10.1007/978-3-319-91527-2_11.
- Kelly C, Pericleous M, Schilsky M. Treatment Options for Wilson Disease 2018, 45-61. DOI: 10.1007/978-3-319-91527-2_3.
- Camarata M, Schilsky M. Treating Other Symptoms of Wilson Disease: The Liver 2018, 87-106. DOI: 10.1007/978-3-319-91527-2_5.
- Pericleous M, Kelly C, Schilsky M. Diagnosis Confirmation and Screening of Wilson Disease 2018, 17-44. DOI: 10.1007/978-3-319-91527-2_2.
- Graper M, Schilsky M. Partnering for Care of Wilson Disease 2018, 203-212. DOI: 10.1007/978-3-319-91527-2_12.
- Weiss K, Askari F, Ferenci P, Ala A, Czlonkowska A, Nicholl D, Bronstein J, Bega D, Schilsky M. Posters Thursday, 12 April 2018 Journal Of Hepatology 2018, 68: s105-s364. DOI: 10.1016/s0168-8278(18)30428-8.
- Schilsky M. Chapter 19 Wilson Disease and Related Disorders 2018, 253-268. DOI: 10.1016/b978-0-323-47874-8.00019-5.
- Camarata M, Ala A, Schilsky M. Update on Wilson disease: focus on WTX-101 Drugs Of The Future 2018, 43: 501. DOI: 10.1358/dof.2018.043.07.2819432.
- Schilsky M, Ala A. Wilson Disease 2017, 799-819. DOI: 10.1002/9781119251316.ch29.
- Randesi M, Levran O, da Rosa J, Hankins J, Rule J, Kreek M, Lee W, Group A, Reuben A, Fontana R, Davern T, McGuire B, Stravitz R, Durkalski V, Liou I, Fix O, Schilsky M, Ganger D, Chung R, Koch D, Reddy K, Rossaro L. Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury Cellular And Molecular Gastroenterology And Hepatology 2017, 3: 500-505. PMID: 28462386, PMCID: PMC5404026, DOI: 10.1016/j.jcmgh.2017.01.008.
- Weiss K, Askari F, Ferenci P, Ala A, Czlonkowska A, Nicholl D, Bronstein J, Bega D, Schilsky M. GS-016 WTX101 in patients newly diagnosed with Wilson disease: final results of a global, prospective phase 2 trial Journal Of Hepatology 2017, 66: s88. DOI: 10.1016/s0168-8278(17)30440-3.
- Weiss K, Ala A, Askari F, Bega D, Bronstein J, Czlonkowska A, Ferenci P, Nicholl D, Schilsky M. PS020 An Ongoing Phase 2, Multi-Centre, Open-Label, Study of WTX101 in Newly Diagnosed Wilson Disease Patients – Early Observations Journal Of Hepatology 2016, 64: s145-s146. DOI: 10.1016/s0168-8278(16)00033-7.
- Do A, Lim J, Liapakis A, Babas G, Caldwell C, Fortune B, Emre S, Kulkarni S, Lempit S, Mistry P, Mulligan D, Rodriguez-Davalos M, Schilsky M, Tichy E, Yoo P, Jakab S. Tu1044 Sofosbuvir-Based Interferon-Free Regimens for Hepatitis C Infection in Patients With Compensated and Decompensated Cirrhosis: Interim Analysis of a Prospective Observational Cohort Gastroenterology 2015, 148: s-1094-s-1095. DOI: 10.1016/s0016-5085(15)33733-1.
- Weiss K, Askari F, Ferenci P, Czlonkowska A, Bronstein J, Schilsky M, Clark D, Hansson J. P1313 : WTX101–201 : Phase 2 study of bis-choline tetrathiomolybdate in newly diagnosed wilson disease patients Journal Of Hepatology 2015, 62: s847. DOI: 10.1016/s0168-8278(15)31492-6.
- Njei B, Schilsky M, Ditah I, Taddei T. Su1011 Should Liver Transplantation Be Reconsidered in Patients With Intrahepatic Cholangiocarcinoma? A Systematic Review and Meta-Regression Analysis of Epidemiologic Evidence Gastroenterology 2015, 148: s-1036. DOI: 10.1016/s0016-5085(15)33541-1.
- Ala A, Aliu E, Schilsky ML. Prospective Pilot Study of a Single Daily Dosage of Trientine for the Treatment of Wilson Disease Digestive Diseases And Sciences 2015, 60: 1433-1439. PMID: 25605552, PMCID: PMC4427615, DOI: 10.1007/s10620-014-3495-6.
- Karvellas CJ, Stravitz R, Battenhouse H, Lee WM, Schilsky ML, Group F. Therapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis Liver Transplantation 2014, 21: 4-12. PMID: 25308108, PMCID: PMC4939841, DOI: 10.1002/lt.24021.
- Kim A, Schilsky M. Radiology in Transplant Current Transplantation Reports 2014, 1: 238-245. DOI: 10.1007/s40472-014-0034-5.
- Thiessen C, Patrón‐Lozano R, Schilsky M, Rodríguez‐Dávalos M. Right Homonymous Hemianopsia and Seizures in a Liver Transplant Recipient American Journal Of Transplantation 2014, 14: 2427-2429. PMID: 25231067, DOI: 10.1111/ajt.12870.
- Kaler S, Schilsky M. In Memoriam: H. Ascher Sellner, M.D. Annals Of The New York Academy Of Sciences 2014, 1314: iv-iv. DOI: 10.1111/nyas.12449.
- Karvellas C, Stravitz R, Battenhouse H, Durkalski V, Lee W, Schilsky M. P319 HYPOTHERMIA IN ACUTE LIVER FAILURE: A MULTI-CENTRE RETROSPECTIVE COHORT ANALYSIS (IT'S ALRIGHT TO BE COOL) Journal Of Hepatology 2014, 60: s173. DOI: 10.1016/s0168-8278(14)60481-5.
- Karvellas C, Stravitz R, Battenhouse H, Durkalski V, Lee W, Schilsky M. A multicenter retrospective cohort analysis of therapeutic hypothermia in acute liver failure Critical Care 2014, 18: p200. PMCID: PMC4068622, DOI: 10.1186/cc13390.
- McGinniss J, Marshall P, Schilsky M, Honiden S. 730 Critical Care Medicine 2013, 41: a180-a181. DOI: 10.1097/01.ccm.0000439968.28678.d4.
- Russ K, Khan A, James L, Schilsky M, Fix O, Lee W, McGuire B. Acute Liver and Multi-organ Failure Secondary to Intentional Iron Overdose The American Journal Of Gastroenterology 2013, 108: s324. DOI: 10.14309/00000434-201310001-01086.
- Chung R, Gordon F, Curry M, Schiano T, Emre S, Corey K, Markmann J, Hertl M, Pomposelli J, Pomfret E, Florman S, Schilsky M, Broering T, Finberg R, Szabo G, Zamore P, Khettry U, Babcock G, Ambrosino D, Leav B, Leney M, Smith H, Molrine D. Human Monoclonal Antibody MBL‐HCV1 Delays HCV Viral Rebound Following Liver Transplantation: A Randomized Controlled Study American Journal Of Transplantation 2013, 13: 1047-1054. PMID: 23356386, PMCID: PMC3618536, DOI: 10.1111/ajt.12083.
- European Association for Study of Liver. J Hepatol. 56:671-685
- Schilsky M, Tavill A. Wilson Disease 2011, 803-824. DOI: 10.1002/9781119950509.ch29.
- Rosencrantz1 2, Schilsky2 3. Wilson Disease: Pathogenesis and Clinical Considerations in Diagnosis and Treatment Seminars In Liver Disease 2011, 31: 245-259. PMID: 21901655, DOI: 10.1055/s-0031-1286056.
- Ala1 A, Schilsky2 M. Genetic Modifiers of Liver Injury in Hereditary Liver Disease Seminars In Liver Disease 2011, 31: 208-214. PMID: 21538285, DOI: 10.1055/s-0031-1276648.
- Schilsky M, Mitchell K. Wilson’s Disease 2010, 5: 655-663. DOI: 10.1007/978-1-4419-7107-4_43.
- Schilsky M, Mistry P. Inherited diseases of copper metabolism: Wilson’s disease and Menkes’ disease 2010, 1688-1693. DOI: 10.1093/med/9780199204854.003.120702.
- Schilsky M, Thiele D. Copper Metabolism and the Liver 2009, 221-233. DOI: 10.1002/9780470747919.ch15.
- Wong R, Gish R, Schilsky M, Frenette C. T1002 Clinical Epidemiology of Wilson Disease in Patients with Concurrent Liver Disease Gastroenterology 2009, 136: a-844. DOI: 10.1016/s0016-5085(09)63889-0.
- Arnon R, Annunziato R, Schilsky M, Miloh T, Suchy F, Iyer K, Kerkar N. M1731 Wilson Disease and Outcomes After Liver Transplantation Gastroenterology 2009, 136: a-420. DOI: 10.1016/s0016-5085(09)61931-4.
- Schilsky M, Lee W, Wiands F. Reply: Hepatology 2009, 49: 1784-1784. DOI: 10.1002/hep.22954.
- Schilsky ML, Honiden S, Arnott L, Emre S. ICU Management of Acute Liver Failure Clinics In Chest Medicine 2009, 30: 71-87. PMID: 19186281, DOI: 10.1016/j.ccm.2008.10.001.
- Schilsky M, Mistry P. Chapter 42 Wilson Disease and the Kidney 2009, 709-713. DOI: 10.1016/b978-0-12-449851-8.00042-5.
- Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH, Fontana RJ, Lee WM, Schilsky ML, Groups P. Screening for Wilson disease in acute liver failure: A comparison of currently available diagnostic tests Hepatology 2008, 48: 1167-1174. PMID: 18798336, PMCID: PMC4881751, DOI: 10.1002/hep.22446.
- Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: An update Hepatology 2008, 47: 2089-2111. PMID: 18506894, DOI: 10.1002/hep.22261.
- Brewer G, Askari F, Lorincz M, Carlson M, Schilsky M, Kluin K, Hedera P, Moretti P, Fink J, Tankanow R, Dick R, Sitterly J. Tetrathiomolybdate versus Trientine in the Initial Treatment of Neurologic Wilson's Disease 2008, 153-166. DOI: 10.1017/cbo9780511666971.010.
- Brewer G, Askari F, Lorincz M, Carlson M, Schilsky M, Kluin K, Hedera P, Moretti P, Fink J, Tankanow R, Dick R, Sitterly J. Tetrathiomolybdate versus Trientine in the Initial Treatment of Neurologic Wilson's Disease Progress In Neurotherapeutics And Neuropsychopharmacology 2007, 3 DOI: 10.1017/s1748232107000043.
- Schilsky M, Kinkhabwala M, Emond J. Chapter 38 The Transplant Operation: What the Hepatologist Should Know 2006, 605-620. DOI: 10.1016/b978-0-323-03675-7.50042-1.
- KOWDLEY K, BRANDHAGEN D, GISH R, BASS N, WEINSTEIN J, SCHILSKY M, FONTANA R, MCCASHLAND T, COTLER S, BACON B. Survival After Liver Transplantation in Patients With Hepatic Iron Overload: The National Hemochromatosis Transplant Registry Gastroenterology 2005, 129: 494-503. DOI: 10.1016/j.gastro.2005.05.004.
- Schilsky M. Wilson's Disease 2004, 643-647. DOI: 10.1016/b0-12-386860-2/00731-0.
- Roberts E, Schilsky M. Corrections: A practice guideline on Wilson disease Hepatology 2003, 38: 536-536. DOI: 10.1002/hep.510380241.
- Korman J, Schiodt F, Balko J, Lee W, Schilsky M, Group A. Elevation of serum ferritin and survival of patients with acute liver failure Gastroenterology 2003, 124: a756. DOI: 10.1016/s0016-5085(03)83818-0.
- Joseph B, Bhargava K, Kandimalla J, Malhi H, Schilsky M, Palestro C, Jain D, Gupta S. Mechanism of sestamibi retention and clearance from myocardium and other organs Journal Of The American College Of Cardiology 2003, 41: 444. DOI: 10.1016/s0735-1097(03)81349-9.
- Branch A, Walewski J, Gutierrez J, Fernandez E, Im G, Dieterich D, Schiano T, Sigal S, Schilsky M, Schwartz M, Kyrk C, Muerhoff A, Leary T, Stewart J, Dawson G, Desai S. 640 HCV alternate reading frame proteins (ARFPS) may be virulence factors that help the virus survive adverse conditions Hepatology 2003, 38: 468-469. DOI: 10.1016/s0270-9139(03)80682-1.
- Wai C, Fontana R, Schilsky M, McCashland T, Han S, Polson J, Hussain M, Lee W, Lok A. 815 Molecular epidemiology of hepatitis B virus-related acute liver failure in the United States: a multicenter case control study Hepatology 2003, 38: 555. DOI: 10.1016/s0270-9139(03)80857-1.
- Schilsky M. The irony of treating Wilson's disease The American Journal Of Gastroenterology 2001, 96: ajg2001764. PMID: 11721750, DOI: 10.1111/j.1572-0241.2001.05254.x.
- Emre S, Atillasoy E, Ozdemir S, Schilsky M, Varma C, Thung S, Sternlieb I, Guy S, Sheiner P, Schwartz M, Miller C. ORTHOTOPIC LIVER TRANSPLANTATION FOR WILSON’S DISEASE Transplantation 2001, 72: 1232-1236. PMID: 11602847, DOI: 10.1097/00007890-200110150-00008.
- Schilsky M, Mistry P. Metabolic liver disease Current Opinion In Gastroenterology 2001, 17: 221-231. PMID: 17031163, DOI: 10.1097/00001574-200105000-00005.
- Irani A, Malhi H, Slehria S, Gorla G, Volenberg I, Schilsky M, Gupta S. Correction of Liver Disease Following Transplantation of Normal Rat Hepatocytes into Long–Evans Cinnamon Rats Modeling Wilson's Disease Molecular Therapy 2001, 3: 302-309. PMID: 11273771, DOI: 10.1006/mthe.2001.0271.
- Schilsky M. Treatment of Wilson’s disease: What are the relative roles of penicillamine, trientine, and zinc supplementation? Current Colorectal Cancer Reports 2001, 3: 54-59. PMID: 11177695, DOI: 10.1007/s11894-001-0041-4.
- Schilsky M, Mistry P. Inherited metabolic disease Current Opinion In Gastroenterology 2000, 16: 219-230. PMID: 17023879, DOI: 10.1097/00001574-200005000-00004.
- Schilsky M, Irani A, Gorla G, Volenberg I, Gupta S. Biliary copper excretion capacity in intact animals: Correlation between ATP7B function, hepatic mass, and biliary copper excretion Journal Of Biochemical And Molecular Toxicology 2000, 14: 210-214. PMID: 10789499, DOI: 10.1002/(sici)1099-0461(2000)14:4<210::aid-jbt5>3.0.co;2-g.
- Schilsky M. Inherited metabolic disease Current Opinion In Gastroenterology 1999, 15: 200-207. PMID: 17023946, DOI: 10.1097/00001574-199905000-00004.
- Tavill A, Schilsky M. Wilson’s disease Current Treatment Options In Gastroenterology 1999, 2: 68-71. PMID: 11096575, DOI: 10.1007/s11938-999-0021-6.
- Rajvanshi P, Liu D, Ott M, Gagandeep S, Schilsky M, Gupta S. Fractionation of Rat Hepatocyte Subpopulations with Varying Metabolic Potential, Proliferative Capacity, and Retroviral Gene Transfer Efficiency Experimental Cell Research 1998, 244: 405-419. PMID: 9806791, DOI: 10.1006/excr.1998.4223.
- Schilsky M, Stockert R, Kesner A, Gorla G, Gagliardi G, Terada K, Miura N, Czaja M. Copper resistant human hepatoblastoma mutant cell lines without metallothionein induction overexpress ATP7B Hepatology 1998, 28: 1347-1356. PMID: 9794921, DOI: 10.1002/hep.510280525.
- Terada K, Schilsky M, Miura N, Sugiyama T. ATP7B (WND) protein The International Journal Of Biochemistry & Cell Biology 1998, 30: 1063-1067. PMID: 9785470, DOI: 10.1016/s1357-2725(98)00073-9.
- Schilsky M. Inherited metabolic disease Current Opinion In Gastroenterology 1998, 14: 200-207. DOI: 10.1097/00001574-199805000-00004.
- Meerson N, Delautier D, Durand‐Schneider A, Moreau A, Schilsky M, Sternlieb I, Feldmann G, Maurice M. Identification of B10, an alkaline phosphodiesterase of the apical plasma membrane of hepatocytes and biliary cells, in rat serum: Increased levels following bile duct ligation and during the development of cholangiocarcinoma Hepatology 1998, 27: 563-568. PMID: 9462658, DOI: 10.1002/hep.510270234.
- Schilsky M, Sternlieb I. Wilson’s Disease 1998, 285-292. DOI: 10.1007/978-1-4612-1808-1_21.
- Schilsky M, Sternlieb I. Genetic Hemochromatosis 1998, 241-247. DOI: 10.1007/978-1-4612-1808-1_18.
- Schilsky M. Inherited metabolic disease Current Opinion In Gastroenterology 1997, 13: 194-198. DOI: 10.1097/00001574-199705000-00004.
- Sternlieb I, Quintana N, Volenberg I, Schilsky M. An array of mitochondrial alterations in the hepatocytes of long‐evans cinnamon rats Hepatology 1995, 22: 1782-1787. PMID: 7489989, DOI: 10.1002/hep.1840220626.
- Sternlieb I, Quintana N, Volenberg I, Schilsky M. An array of mitochondrial alterations in the hepatocytes of Long-Evans Cinnamon rats Hepatology 1995, 22: 1782-1787. DOI: 10.1016/0270-9139(95)90206-6.
- Schilsky M. In vitro modeling of liver membrane copper transport Hepatology 1995, 22: 1340-1342. PMID: 7557893, DOI: 10.1002/hep.1840220449.
- Schilsky M. In Vitro modeling of liver membrane copper transports Dijkstra M, Veld GI, van den Berg GJ, Muller M, Kuipers F, Vonk RJ. J. Clin Invest 1995; 95: 412–416 Hepatology 1995, 22: 1340-1342. DOI: 10.1016/0270-9139(95)90651-7.
- Terada K, Manchikalapudi P, Noiva R, Jauregui H, Stockert R, Schilsky M. Secretion, Surface Localization, Turnover, and Steady State Expression of Protein Disulfide Isomerase in Rat Hepatocytes (∗) Journal Of Biological Chemistry 1995, 270: 20410-20416. PMID: 7657616, DOI: 10.1074/jbc.270.35.20410.
- Fox I, Chowdhury N, Gupta S, Kondapalli R, Schilsky M, Stockert R, Chowdhury J. Conditional immortalization of gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin‐UDP‐glucuronosyltransferase gene transfer Hepatology 1995, 21: 837-846. PMID: 7875682, DOI: 10.1002/hep.1840210334.
- Fox I, Chowdhury N, Gupta S, Kondapalli R, Schilsky M, Stockert R, Chowdhury J. Conditional immortalization of gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin-UDP-glucuronosyltransferase gene transfer Hepatology 1995, 21: 837-846. DOI: 10.1016/0270-9139(95)90539-1.
- Schilsky M. Identification of the Wilson's disease gene: Clues for disease pathogenesis and the potential for molecular diagnosis Hepatology 1994, 20: 529-533. PMID: 8045514, DOI: 10.1002/hep.1840200235.
- Schilsky M, Scheinberg I, Sternlieb I. Liver transplantation for Wilson's disease: Indications and outcome Hepatology 1994, 19: 583-587. PMID: 8119682, DOI: 10.1002/hep.1840190307.
- Schilsky M, Shafritz D. Biochemistry and molecular biology of the liver Current Opinion In Gastroenterology 1992, 8: 418-425. DOI: 10.1097/00001574-199206000-00009.
- Schilsky M, Scheinberg I, Sternlieb I. Prognosis of Wilsonian chronic active hepatitis Gastroenterology 1991, 100: 762-767. PMID: 1993498, DOI: 10.1016/0016-5085(91)80023-3.
- Scheinberg I, Sternlieb I, Schilsky M, Stockert R. PENICILLAMINE MAY DETOXIFY COPPER IN WILSON'S DISEASE The Lancet 1987, 330: 95. PMID: 2885586, DOI: 10.1016/s0140-6736(87)92753-x.
- Yale New Haven Transplantation CenterDanbury Hospital24 Hospital AvenueDanbury, CT 06810
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- Yale Transplantation Center; Long Ridge Medical Center260 Long Ridge RoadStamford, CT 06902