- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Yale Therapeutic RadiologyHunter Building15 York StreetNew Haven, CT 06510
James E. Hansen, MD, MS
Biography
James E. Hansen, MD, is a therapeutic radiologist who specializes in treating a variety of conditions, including brain tumors, head and neck cancers, lung cancer, lymphoma, skin cancer, and cancers of the gastrointestinal and genitourinary systems.
Dr. Hansen employs advanced techniques such as stereotactic radiosurgery and stereotactic body radiation therapy to target tumors precisely while minimizing damage to surrounding healthy tissue. He is committed to finding the right balance between effective treatment and protecting normal organ function, especially in patients with brain tumors.
“Every patient journey is unique. Please know that in good times or challenging times, you are never battling this disease alone,” Dr. Hansen says. As an associate professor of therapeutic radiology at Yale School of Medicine, Dr. Hansen's research explores how certain autoantibodies—molecules generated in autoimmune disorders—might be harnessed to fight cancer.
Dr. Hansen is particularly excited about advancements in drug design that allow treatments to cross the blood-brain barrier, offering new hope for brain tumor patients. “I have never been more excited and optimistic about the future benefits of therapies that cross the blood-brain barrier and target brain tumors,” he explains. Dr. Hansen completed his medical training at UCLA School of Medicine, followed by a residency and chief residency in therapeutic radiology at Yale School of Medicine.
Titles
- Associate Professor of Therapeutic Radiology
- Chief, Gamma Knife Program, Therapeutic Radiology
- Radiation Safety, Therapeutic Radiology
- Co-Director, Stereotactic Radiosurgery and Body Radiotherapy Fellowship, Therapeutic Radiology
Education & Training
- Chief ResidentYale School of Medicine (2012)
- ResidentYale School of Medicine (2011)
- Postdoctoral ScholarUCLA (2007)
- MDUCLA School of Medicine (2004)
- MSUniversity of California, Los Angeles, Biochemistry and Molecular Biology (1999)
Additional Information
- AB of Radiology, Radiation Oncology (2013)
- Chung A, Ghankot R, Li D, Omiunu A, Singh M, Jester N, Tommasini S, Hansen J, Chiang V, Buono F, Mahajan A, Schwartz N. Volumetric Assessment of Vestibular Schwannomas Exhibiting Internal Growth After Stereotactic Radiosurgery: Application of Artificial Intelligence. Clinical Neuroradiology 2026, 1-11. PMID: 42584671, DOI: 10.1007/s00062-026-01707-8.
- Becht K, Lindsay M, Soulos P, Singh C, Hansen J, An Y, Aneja S, Goldberg S, Chiang V, Park H. Disparities in stereotactic radiosurgery receipt in patients with brain metastases from non-small cell lung cancer. Journal Of Neuro-Oncology 2026, 177: 151. PMID: 42141140, DOI: 10.1007/s11060-026-05615-2.
- Robert S, Hansen J, Chiang V. Recognition and Management of Adverse Radiation Effects. 2026, 362-374. DOI: 10.1201/9781003649335-35.
- Jin Y, Cao F, Xie Y, Davis S, Dong G, Nigwekar S, Hansen J, Guzman R, Cai Y. High Phosphate and Low Protein Mediate Arterial and Cutaneous Vascular Calcification in CKD Mice. Journal Of The American Society Of Nephrology 2025, 37: 683-699. PMID: 40960881, PMCID: PMC12448113, DOI: 10.1681/asn.0000000875.
- Chen X, Tang X, Xie Y, Cuffari B, Tang C, Cao F, Gao X, Meng Z, Noble P, Young M, Turk O, Shirali A, Gera J, Nishimura R, Zhou J, Hansen J. A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells. Science Signaling 2025, 18: eadk3320-eadk3320. PMID: 40132052, PMCID: PMC12076517, DOI: 10.1126/scisignal.adk3320.
- Cao F, Tang C, Chen X, Tu Z, Jin Y, Turk O, Nishimura R, Ebens A, Dubljevic V, Campbell J, Zhou J, Hansen J. Cathepsin B Nuclear Flux in a DNA-Guided “Antinuclear Missile” Cancer Therapy. ACS Central Science 2024, 10: 1562-1572. PMID: 39220699, PMCID: PMC11363321, DOI: 10.1021/acscentsci.4c00559.
- May C, Noble P, Herzog E, Meffre E, Hansen J. Nuclear-penetrating scleroderma autoantibody inhibits topoisomerase 1 cleavage complex formation. Biochemical And Biophysical Research Communications 2024, 720: 150123. PMID: 38759301, DOI: 10.1016/j.bbrc.2024.150123.
- Hino C, Chan G, Jordaan G, Chang S, Saunders J, Bashir M, Hansen J, Gera J, Weisbart R, Nishimura R. Cellular protection from H2O2 toxicity by Fv-Hsp70: protection via catalase and gamma-glutamyl-cysteine synthase. Cell Stress And Chaperones 2023, 28: 429-439. PMID: 37171750, PMCID: PMC10352194, DOI: 10.1007/s12192-023-01349-6.
- Draeger E, Chen Z, Hansen J, Chiang V, Tien C. Preliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems. Journal Of Applied Clinical Medical Physics 2023, 24: e13907. PMID: 36660774, PMCID: PMC10161057, DOI: 10.1002/acm2.13907.
- Chen X, Cuffari BJ, Dubljevic V, Shirali A, Zhou J, Campbell JA, Suits SC, O'Sullivan KM, Hansen JE. Inhibition of NETosis by a Nuclear-Penetrating Anti-DNA Autoantibody. ImmunoHorizons 2022, 6: 356-365. PMID: 35697479, DOI: 10.4049/immunohorizons.2100091.
- Glauzy S, Olson B, May CK, Parisi D, Massad C, Hansen JE, Ryu C, Herzog EL, Meffre E. Defective Early B Cell Tolerance Checkpoints in Patients With Systemic Sclerosis Allow the Production of Self Antigen–Specific Clones. Arthritis & Rheumatology 2021, 74: 307-317. PMID: 34279059, PMCID: PMC8766600, DOI: 10.1002/art.41927.
- Cheok S, Hansen J, Chiang V. Recognition and Management of Adverse Radiation Effects. 2021, 391-404. DOI: 10.1201/9781003167464-36.
- Rattray Z, Deng G, Zhang S, Shirali A, May CK, Chen X, Cuffari BJ, Liu J, Zou P, Rattray N, Johnson CH, Dubljevic V, Campbell JA, Huttner A, Baehring JM, Zhou J, Hansen JE. ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody. JCI Insight 2021, 6: e145875. PMID: 34128837, PMCID: PMC8410084, DOI: 10.1172/jci.insight.145875.
- Peters GW, Tien CJ, Chiang V, Yu J, Hansen JE, Aneja S. Impact of tissue heterogeneity correction on Gamma Knife stereotactic radiosurgery of acoustic neuromas. Journal Of Radiosurgery And SBRT 2021, 7: 207-212. PMID: 33898084, PMCID: PMC8055239.
- Ladouceur A, Tissera H, Clarke A, Ramsey-Goldman R, Gordon C, Hansen J, Bernatsky S. Chapter 48 Malignancies in systemic lupus erythematosus. 2021, 461-467. DOI: 10.1016/b978-0-12-814551-7.00048-9.
- Chen Y, Jiang T, Zhang H, Gou X, Han C, Wang J, Chen AT, Ma J, Liu J, Chen Z, Jing X, Lei H, Wang Z, Bao Y, Baqri M, Zhu Y, Bindra RS, Hansen JE, Dou J, Huang C, Zhou J. LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy. Nature Cell Biology 2020, 22: 1276-1285. PMID: 33005030, PMCID: PMC7962994, DOI: 10.1038/s41556-020-00586-6.
- Miccio JA, Barsky A, Gao S, Verma V, Noticewala SS, Jairam V, Johnson SB, Yu JB, Hansen JE, Aneja S, An Y, Decker RH, Bulent Omay S, Li J, Kurtz GA, Alonso-Basanta M, Lee JYK, Chiang VL, Park HS. Multi-institutional retrospective review of stereotactic radiosurgery for brain metastasis in patients with small cell lung cancer without prior brain-directed radiotherapy. Journal Of Radiosurgery And SBRT 2020, 7: 19-27. PMID: 32802575, PMCID: PMC7406345.
- Hansen J, Dilektasli A, Porszasz J, Stringer W, Pak Y, Rossiter H, Casaburi R. A New Bronchodilator Response Grading Strategy Identifies Distinct Patient Populations. Annals Of The American Thoracic Society 2019, 16: 1504-1517. PMID: 31404502, PMCID: PMC6956832, DOI: 10.1513/annalsats.201901-030oc.
- Yu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Mahajan A, Omay S, Chiang V. Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials. Journal Of Radiation Oncology 2019, 8: 39-46. DOI: 10.1007/s13566-018-0370-7.
- Isenberg D, Giles I, Hansen J, Rahman A. 27 Antinuclear Antibodies, Antibodies to DNA, Histones, and Nucleosomes. 2019, 355-365. DOI: 10.1016/b978-0-323-47927-1.00027-x.
- Kim C, Van Iterson E, Hansen J, MacCarter D, Johnson B. Streamlining cardiopulmonary exercise testing for use as a screening and tracking tool in primary care. Pulmonary Circulation 2018, 8: 1-8. PMID: 29693481, PMCID: PMC5987906, DOI: 10.1177/2045894018776489.
- Loganadane G, Kelly JR, Lee NC, Kann BH, Mahajan A, Hansen JE, Belkacémi Y, Yarbrough W, Husain ZA. Incidence of radiographically occult nodal metastases in HPV+ oropharyngeal carcinoma: Implications for reducing elective nodal coverage. Practical Radiation Oncology 2018, 8: 397-403. PMID: 29730282, DOI: 10.1016/j.prro.2018.03.009.
- Tan C, Rossiter H, Porszasz J, Bowen T, Witte K, Stringer W, Casaburi R, Hansen J. Reliability and Physiological Interpretation of Pulmonary Gas Exchange by “Circulatory Equivalents” in Chronic Heart Failure. Journal Of The American Heart Association 2018, 7: e008072. PMID: 29588313, PMCID: PMC5907590, DOI: 10.1161/jaha.117.008072.
- Rattray Z, Dubljevic V, Rattray NJW, Greenwood DL, Johnson CH, Campbell JA, Hansen JE. Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications. Biochemical And Biophysical Research Communications 2018, 496: 858-864. PMID: 29374508, DOI: 10.1016/j.bbrc.2018.01.139.
- Bernatsky S, Ramsey-Goldman R, Petri M, Urowitz MB, Gladman DD, Fortin PR, Yelin EH, Ginzler E, Hanly JG, Peschken C, Gordon C, Nived O, Aranow C, Bae SC, Isenberg D, Rahman A, Hansen JE, Pierre Y, Clarke AE. Smoking Is the Most Significant Modifiable Lung Cancer Risk Factor in Systemic Lupus Erythematosus. The Journal Of Rheumatology 2018, 45: 393-396. PMID: 29335347, PMCID: PMC5834350, DOI: 10.3899/jrheum.170652.
- Johnson CH, Santidrian AF, LeBoeuf SE, Kurczy ME, Rattray NJW, Rattray Z, Warth B, Ritland M, Hoang LT, Loriot C, Higa J, Hansen JE, Felding BH, Siuzdak G. Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids. Cancer & Metabolism 2017, 5: 9. PMID: 29093815, PMCID: PMC5663111, DOI: 10.1186/s40170-017-0171-2.
- Kim C, Hansen J, Anderson D, McCarter D, Anderson S, Johnson B. Algorithm For Predicting Disease Likelihood From Noninvasive Submaximal Cardiopulmonary Exercise Testing. Medicine & Science In Sports & Exercise 2017, 49: 408. DOI: 10.1249/01.mss.0000517998.06927.d0.
- Rattray NJW, Charkoftaki G, Rattray Z, Hansen JE, Vasiliou V, Johnson CH. Environmental Influences in the Etiology of Colorectal Cancer: the Premise of Metabolomics. Current Pharmacology Reports 2017, 3: 114-125. PMID: 28642837, PMCID: PMC5475285, DOI: 10.1007/s40495-017-0088-z.
- Kim C, Hansen J, MacCarter D, Johnson B. Algorithm for Predicting Disease Likelihood From a Submaximal Exercise Test. Therapeutic Advances In Pulmonary And Critical Care Medicine 2017, 11: 1179548417719248. PMID: 28757799, PMCID: PMC5513526, DOI: 10.1177/1179548417719248.
- Bernatsky S, Ramsey-Goldman R, Petri M, Urowitz MB, Gladman DD, Fortin P, Ginzler E, Romero-Diaz J, Peschken C, Jacobsen S, Hanly JG, Gordon C, Nived O, Yelin EH, Isenberg D, Rahman A, Bae SC, Joseph L, Witte T, Ruiz-Irastorza G, Aranow C, Kamen D, Sturfeldt G, Foulkes WD, Hansen JE, St Pierre Y, Raymer PC, Tessier-Cloutier B, Clarke AE. Breast cancer in systemic lupus. Lupus 2016, 26: 311-315. PMID: 27687028, PMCID: PMC5250552, DOI: 10.1177/0961203316664595.
- Chen Z, Patel JM, Noble PW, Garcia C, Hong Z, Hansen JE, Zhou J. A lupus anti-DNA autoantibody mediates autocatalytic, targeted delivery of nanoparticles to tumors. Oncotarget 2016, 7: 59965-59975. PMID: 27494868, PMCID: PMC5312362, DOI: 10.18632/oncotarget.11015.
- Dilektasli A, Porszasz J, Casaburi R, Stringer W, Bhatt S, Pak Y, Rossiter H, Washko G, Castaldi P, San Jose Estepar R, Hansen J, investigators C. A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria. Chest 2016, 150: 1080-1090. PMID: 27452770, PMCID: PMC5103018, DOI: 10.1016/j.chest.2016.06.047.
- Noble PW, Bernatsky S, Clarke AE, Isenberg DA, Ramsey-Goldman R, Hansen JE. DNA-damaging autoantibodies and cancer: the lupus butterfly theory. Nature Reviews Rheumatology 2016, 12: 429-434. PMID: 27009542, DOI: 10.1038/nrrheum.2016.23.
- Tissera H, Clarke A, Goldman R, Gordon C, Hansen J, Bernatsky S. Chapter 46 Malignancies in Systemic Lupus Erythematosus. 2016, 411-415. DOI: 10.1016/b978-0-12-801917-7.00046-2.
- Yao Y, Sun X, Zheng Z, Wang G, Hansen J, Stringer W, Wasserman K, Hu S. Better parameters of ventilation-CO₂output relationship predict death in CHF patients. Chinese Journal Of Applied Physiology 2015, 31: 508-16. PMID: 27215018.
- Weisbart RH, Chan G, Jordaan G, Noble PW, Liu Y, Glazer PM, Nishimura RN, Hansen JE. DNA-dependent targeting of cell nuclei by a lupus autoantibody. Scientific Reports 2015, 5: 12022. PMID: 26156563, PMCID: PMC4496662, DOI: 10.1038/srep12022.
- Noble PW, Chan G, Young MR, Weisbart RH, Hansen JE. Optimizing a Lupus Autoantibody for Targeted Cancer Therapy. Cancer Research 2015, 75: 2285-2291. PMID: 25832653, DOI: 10.1158/0008-5472.can-14-2278.
- Hansen J, Porszasz J. Rebuttal From Drs Hansen and Porszasz. Chest 2014, 146: 542-544. PMID: 25180720, DOI: 10.1378/chest.14-0618.
- Hansen J, Porszasz J. Counterpoint: Is an Increase in FEV1 and/or FVC ≥ 12% of Control and ≥ 200 mL the Best Way to Assess Positive Bronchodilator Response? No. Chest 2014, 146: 538-541. PMID: 25180718, DOI: 10.1378/chest.14-0437.
- Noble PW, Young MR, Bernatsky S, Weisbart RH, Hansen JE. A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells. Scientific Reports 2014, 4: 5958. PMID: 25091037, PMCID: PMC5380011, DOI: 10.1038/srep05958.
- Tessier-Cloutier B, Clarke AE, Ramsey-Goldman R, Gordon C, Hansen JE, Bernatsky S. Systemic Lupus Erythematosus and Malignancies A Review Article. Rheumatic Disease Clinics Of North America 2014, 40: 497-506. PMID: 25034158, DOI: 10.1016/j.rdc.2014.04.005.
- Hansen J, Porszasz J, Casaburi R, Stringer W. Re-Defining Lower Limit of Normal for FEV1/FEV6, FEV1/FVC, FEV3/FEV6 and FEV3/FVC to Improve Detection of Airway Obstruction. Chronic Obstructive Pulmonary Diseases Journal Of The COPD Foundation 2014, 2: 94-102. PMID: 28848835, PMCID: PMC5556964, DOI: 10.15326/jcopdf.2.2.2014.0144.
- Hansen J. Human Lung Acinar Structure and Function Are Even Better than Good. American Journal Of Respiratory And Critical Care Medicine 2013, 188: 623-623. PMID: 23992592, DOI: 10.1164/rccm.201302-0405le.
- Cloutier B, Clarke AE, Ramsey-Goldman R, Wang Y, Foulkes W, Gordon C, Hansen JE, Yelin E, Urowitz MB, Gladman D, Fortin PR, Wallace DJ, Petri M, Manzi S, Ginzler EM, Labrecque J, Edworthy S, Dooley MA, Senécal JL, Peschken CA, Bae SC, Isenberg D, Rahman A, Ruiz-Irastorza G, Hanly JG, Jacobsen S, Nived O, Witte T, Criswell LA, Barr SG, Dreyer L, Sturfelt G, Bernatsky S, Clinics S. Breast Cancer in Systemic Lupus Erythematosus. Oncology 2013, 85: 117-121. PMID: 23887245, PMCID: PMC3934367, DOI: 10.1159/000353138.
- Gläser S, Ittermann T, Koch B, Schäper C, Felix S, Völzke H, Könemann R, Ewert R, Hansen J. Influence of smoking and obesity on alveolar-arterial gas pressure differences and dead space ventilation at rest and peak exercise in healthy men and women. Respiratory Medicine 2013, 107: 919-926. PMID: 23510666, DOI: 10.1016/j.rmed.2013.02.013.
- Hansen J. Hooray for the Va/TLC and DlCO/Va. American Journal Of Respiratory And Critical Care Medicine 2013, 187: 107-107. PMID: 23281352, DOI: 10.1164/ajrccm.187.1.107.
- Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH, Glazer PM. Targeting Cancer with a Lupus Autoantibody. Science Translational Medicine 2012, 4: 157ra142. PMID: 23100628, PMCID: PMC3713477, DOI: 10.1126/scitranslmed.3004385.
- Weisbart RH, Gera JF, Chan G, Hansen JE, Li E, Cloninger C, Levine AJ, Nishimura RN. A Cell-Penetrating Bispecific Antibody for Therapeutic Regulation of Intracellular Targets. Molecular Cancer Therapeutics 2012, 11: 2169-2173. PMID: 22863609, DOI: 10.1158/1535-7163.mct-12-0476-t.
- Hansen J, Sun X, Stringer W. A Simple New Visualization of Exercise Data Discloses Pathophysiology and Severity of Heart Failure. Journal Of The American Heart Association 2012, 1: e001883. PMID: 23130146, PMCID: PMC3487328, DOI: 10.1161/jaha.112.001883.
- Hansen J. Has My Patient Responded? American Journal Of Respiratory And Critical Care Medicine 2012, 185: 895-895. PMID: 22505756, DOI: 10.1164/ajrccm.185.8.895.
- Hansen J. A Better Way to Assess Bronchoreversibility. Chest 2012, 141: 1118. PMID: 22474156, DOI: 10.1378/chest.11-2705.
- Sun X, Hansen J, Stringer W. Oxygen Uptake Efficiency Plateau Best Predicts Early Death in Heart Failure. Chest 2011, 141: 1284-1294. PMID: 22030802, PMCID: PMC4694089, DOI: 10.1378/chest.11-1270.
- Sun X, Hansen J, Stringer W. Oxygen uptake efficiency plateau: physiology and reference values. European Journal Of Applied Physiology 2011, 112: 919-928. PMID: 21695524, DOI: 10.1007/s00421-011-2030-0.
- Hansen J. Lower Limit of Normal Is Better Than 70% or 80%. Chest 2011, 139: 6-8. PMID: 21208872, DOI: 10.1378/chest.10-1117.
- Dumitrescu D, Oudiz R, Karpouzas G, Hovanesyan A, Jayasinghe A, Hansen J, Rosenkranz S, Wasserman K. Developing Pulmonary Vasculopathy in Systemic Sclerosis, Detected with Non-Invasive Cardiopulmonary Exercise Testing. PLOS ONE 2010, 5: e14293. PMID: 21179195, PMCID: PMC3001444, DOI: 10.1371/journal.pone.0014293.
- Hansen J. Lung age is a useful concept and calculation. Npj Primary Care Respiratory Medicine 2010, 19: 400-401. PMID: 21042695, PMCID: PMC6602464, DOI: 10.4104/pcrj.2010.00074.
- Chaudhry S, Arena R, Hansen J, Lewis G, Myers J, Sperling L, LaBudde B, Wasserman K. The Utility of Cardiopulmonary Exercise Testing to Detect and Track Early-Stage Ischemic Heart Disease. Mayo Clinic Proceedings 2010, 85: 928-932. PMID: 20884826, PMCID: PMC2947965, DOI: 10.4065/mcp.2010.0183.
- Hansen J. Assessment of bronchoreversibility in severe emphysema. European Respiratory Journal 2010, 36: 972-972. PMID: 20889470, DOI: 10.1183/09031936.00070010.
- Hansen J. Measuring the lung age of smokers. Npj Primary Care Respiratory Medicine 2010, 19: 286-287. PMID: 20676592, PMCID: PMC6602245, DOI: 10.4104/pcrj.2010.00048.
- Sven G, Koch B, Ittermann T, Christoph S, Marcus D, Felix S, Henry V, Ewert R, Hansen J. Influence of age, sex, body size, smoking, and β blockade on key gas exchange exercise parameters in an adult population. European Journal Of Preventive Cardiology 2010, 17: 469-476. PMID: 20305565, DOI: 10.1097/hjr.0b013e328336a124.
- Oudiz R, Midde R, Hovanesyan A, Sun X, Roveran G, Hansen J, Wasserman K. Usefulness of Right-to-Left Shunting and Poor Exercise Gas Exchange for Predicting Prognosis in Patients With Pulmonary Arterial Hypertension. The American Journal Of Cardiology 2010, 105: 1186-1191. PMID: 20381675, PMCID: PMC3031421, DOI: 10.1016/j.amjcard.2009.12.024.
- Sun X, Hansen J, Beshai J, Wasserman K. Oscillatory Breathing and Exercise Gas Exchange Abnormalities Prognosticate Early Mortality and Morbidity in Heart Failure. Journal Of The American College Of Cardiology 2010, 55: 1814-1823. PMID: 20413031, DOI: 10.1016/j.jacc.2009.10.075.
- Zhan X, Ander BP, Liao IH, Hansen JE, Kim C, Clements D, Weisbart RH, Nishimura RN, Sharp FR. Recombinant Fv-Hsp70 Protein Mediates Neuroprotection After Focal Cerebral Ischemia in Rats. Stroke 2010, 41: 538-543. PMID: 20075343, PMCID: PMC2957177, DOI: 10.1161/strokeaha.109.572537.
- Hansen J, Sun X, Wasserman K. Calculating gambling odds and lung ages for smokers. European Respiratory Journal 2009, 35: 776-780. PMID: 19797127, DOI: 10.1183/09031936.00107709.
- Heinze E, Baldwin S, Chan G, Hansen J, Song J, Clements D, Aragon R, Nishimura R, Reeves M, Weisbart R. Antibody-mediated FOXP3 protein therapy induces apoptosis in cancer cells in vitro and inhibits metastasis in vivo. International Journal Of Oncology 2009, 35: 167-73. PMID: 19513564, DOI: 10.3892/ijo_00000325.
- Chaudhry S, Arena R, Wasserman K, Hansen J, Lewis G, Myers J, Belardinelli R, LaBudde B, Menasco N, Boden W. The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia. International Journal Of Cardiology 2009, 148: e7-e9. PMID: 19233492, PMCID: PMC3062706, DOI: 10.1016/j.ijcard.2009.01.055.
- Robbins J, Duscha B, Bensimhon D, Wasserman K, Hansen J, Houmard J, Annex B, Kraus W. A sex-specific relationship between capillary density and anaerobic threshold. Journal Of Applied Physiology 2009, 106: 1181-1186. PMID: 19164774, PMCID: PMC2698638, DOI: 10.1152/japplphysiol.90947.2008.
- Chaudhry S, Arena R, Wasserman K, Hansen J, Lewis G, Myers J, Chronos N, Boden W. Exercise-Induced Myocardial Ischemia Detected by Cardiopulmonary Exercise Testing. The American Journal Of Cardiology 2009, 103: 615-619. PMID: 19231322, PMCID: PMC3035935, DOI: 10.1016/j.amjcard.2008.10.034.
- Hansen J. Assessing small airways disease. European Respiratory Journal 2008, 32: 1410-1410. PMID: 18978142, DOI: 10.1183/09031936.00088908.
- Hansen J, Sun X, Adame D, Wasserman K. Argument for changing criteria for bronchodilator responsiveness. Respiratory Medicine 2008, 102: 1777-1783. PMID: 18701269, DOI: 10.1016/j.rmed.2008.06.019.
- Ma QL, Yang F, Calon F, Ubeda OJ, Hansen JE, Weisbart RH, Beech W, Frautschy SA, Cole GM. p21-activated Kinase-aberrant Activation and Translocation in Alzheimer Disease Pathogenesis*. Journal Of Biological Chemistry 2008, 283: 14132-14143. PMID: 18347024, PMCID: PMC2376243, DOI: 10.1074/jbc.m708034200.
- Oudiz R, Roveran G, Hansen J, Sun X, Wasserman K. Effect of sildenafil on ventilatory efficiency and exercise tolerance in pulmonary hypertension. European Journal Of Heart Failure 2007, 9: 917-921. PMID: 17707133, PMCID: PMC2071948, DOI: 10.1016/j.ejheart.2007.06.013.
- Hansen J, Ulubay G, Chow B, Sun X, Wasserman K. Mixed-Expired and End-Tidal CO2 Distinguish Between Ventilation and Perfusion Defects During Exercise Testing in Patients With Lung and Heart Diseases. Chest 2007, 132: 977-983. PMID: 17573506, DOI: 10.1378/chest.07-0619.
- Hansen J, Sun X, Wasserman K. Shifting the Goalpost To Stay Younger Normal Spirometry but Short of Breath! Chest 2007, 131: 1990. DOI: 10.1016/s0012-3692(15)37550-4.
- Hansen JE, Tse CM, Chan G, Heinze ER, Nishimura RN, Weisbart RH. Intranuclear Protein Transduction through a Nucleoside Salvage Pathway*. Journal Of Biological Chemistry 2007, 282: 20790-20793. PMID: 17525162, DOI: 10.1074/jbc.c700090200.
- Wasserman K, Sun X, Hansen J. Effect of Biventricular Pacing on the Exercise Pathophysiology of Heart Failure. Chest 2007, 132: 250-261. PMID: 17505041, DOI: 10.1378/chest.06-2872.
- Hansen JE, Fischer LK, Chan G, Chang SS, Baldwin SW, Aragon RJ, Carter JJ, Lilly M, Nishimura RN, Weisbart RH, Reeves ME. Antibody-Mediated p53 Protein Therapy Prevents Liver Metastasis In vivo. Cancer Research 2007, 67: 1769-1774. PMID: 17308119, DOI: 10.1158/0008-5472.can-06-3783.
- Hansen J, Sun X, Wasserman K. Spirometric Criteria for Airway Obstruction Use Percentage of FEV1/FVC Ratio Below the Fifth Percentile, Not < 70%. Chest 2007, 131: 349-355. PMID: 17296632, DOI: 10.1378/chest.06-1349.
- Hansen J, Sun X, Wasserman K. From the authors. European Respiratory Journal 2006, 28: 1289-1290. DOI: 10.1183/09031936.00112706.
- Hansen J, Sun X, Wasserman K. Ethnic- and Sex-free Formulae for Detection of Airway Obstruction. American Journal Of Respiratory And Critical Care Medicine 2006, 174: 493-498. PMID: 16778160, DOI: 10.1164/rccm.200604-517oc.
- Hansen JE, Sohn W, Kim C, Chang SS, Huang NC, Santos DG, Chan G, Weisbart RH, Nishimura RN. Antibody-mediated Hsp70 protein therapy. Brain Research 2006, 1088: 187-196. PMID: 16630585, DOI: 10.1016/j.brainres.2006.03.025.
- Hansen J, Sun X, Wasserman K. Should forced expiratory volume in six seconds replace forced vital capacity to detect airway obstruction? European Respiratory Journal 2006, 27: 1244-1250. PMID: 16455822, DOI: 10.1183/09031936.06.00136905.
- Hansen J, Sun X, Wasserman K. Discriminating Measures and Normal Values for Expiratory Obstruction. Chest 2006, 129: 369-377. PMID: 16478854, DOI: 10.1378/chest.129.2.369.
- Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nature Neuroscience 2006, 9: 234-242. PMID: 16415866, DOI: 10.1038/nn1630.
- Cardiopulmonary Exercise Testing and Six-Minute Walk Correlations in Pulmonary Arterial HypertensionOudiz R, Barst R, Hansen J, Sun X, Garofano R, Wu X, Wasserman K. Cardiopulmonary Exercise Testing and Six-Minute Walk Correlations in Pulmonary Arterial Hypertension. The American Journal Of Cardiology 2005, 97: 123-126. PMID: 16377296, DOI: 10.1016/j.amjcard.2005.07.129.
- Hansen JE, Weisbart RH, Nishimura RN. Antibody Mediated Transduction of Therapeutic Proteins into Living Cells. The Scientific World JOURNAL 2005, 5: 782-788. PMID: 16170440, PMCID: PMC5936519, DOI: 10.1100/tsw.2005.98.
- Wasserman K, Hansen J, Sue D, Stringer W, Whipp B. Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications, 4th Edition. Medicine & Science In Sports & Exercise 2005, 37: 1249. DOI: 10.1249/01.mss.0000172593.20181.14.
- Yasunobu Y, Oudiz R, Sun X, Hansen J, Wasserman K. End-tidal Pco2 Abnormality and Exercise Limitation in Patients With Primary Pulmonary Hypertension. Chest 2005, 127: 1637-1646. PMID: 15888840, DOI: 10.1378/chest.127.5.1637.
- Weisbart RH, Hansen JE, Nishimura RN, Chan G, Wakelin R, Chang SS, Baresi L, Chamberlain JS. An intracellular delivery vehicle for protein transduction of micro-dystrophin. Journal Of Drug Targeting 2005, 13: 81-87. PMID: 15823959, DOI: 10.1080/10611860400029002.
- Weisbart R, Chan G, Wakelin R, Nishimura R, Hansen J, Chang S, Baresi L, Chamberlain J. Development of a Lupus Anti-Dna Antibody as An Intracellular Delivery Vehicle for Protein Transduction of Micro-Dystrophin. Journal Of Investigative Medicine 2005, 53: 129-129. DOI: 10.1177/1081558905053001283.
- Weisbart RH, Hansen JE, Chan G, Wakelin R, Chang SS, Heinze E, Miller CW, Koeffler PH, Yang F, Cole GM, Min YS, Nishimura RN. Antibody-mediated transduction of p53 selectively kills cancer cells. International Journal Of Oncology 2004, 25: 1867-73. PMID: 15547728, DOI: 10.3892/ijo.25.6.1867.
- Hansen J, Sun X, Yasunobu Y, Garafano R, Gates G, Barst R, Wasserman K. Reproducibility of Cardiopulmonary Exercise Measurements in Patients With Pulmonary Arterial Hypertension. Chest 2004, 126: 816-824. PMID: 15364761, DOI: 10.1378/chest.126.3.816.
- Sun X, Hansen J, Oudiz R, Wasserman K. Pulmonary function in primary pulmonary hypertension. Journal Of The American College Of Cardiology 2003, 41: 1028-1035. PMID: 12651053, DOI: 10.1016/s0735-1097(02)02964-9.
- Sun X, Hansen J, Garatachea N, Storer T, Wasserman K. Ventilatory Efficiency during Exercise in Healthy Subjects. American Journal Of Respiratory And Critical Care Medicine 2002, 166: 1443-1448. PMID: 12450934, DOI: 10.1164/rccm.2202033.
- CHUANG M, TING H, OTSUKA T, SUN X, CHIU F, HANSEN J, WASSERMAN K. Muscle deoxygenation as related to work rate. Medicine & Science In Sports & Exercise 2002, 34: 1614-1623. PMID: 12370563, DOI: 10.1097/00005768-200210000-00013.
- Hansen J, Casaburi R. Mitochondrial disorders and exertional intolerance: Controversy continues. American Journal Of Respiratory And Critical Care Medicine 2002, 166: 118-120. PMID: 12091181, DOI: 10.1164/ajrccm.166.1.16611.
- Hansen J. Sarcoidosis and Gas Exchange Measures. Chest 2002, 121: 1004. PMID: 11888995, DOI: 10.1378/chest.121.3.1004.
- Sun X, Hansen J, Oudiz R, Wasserman K. Gas Exchange Detection of Exercise-Induced Right-to-Left Shunt in Patients With Primary Pulmonary Hypertension. Circulation 2002, 105: 54-60. PMID: 11772876, DOI: 10.1161/hc0102.101509.
- Godfrey S, Kazemi H, Systrom D, Wasserman K, Sun X, Hansen J, Ting H, Stringer W. Carbon Dioxide Pressure-Concentration Relationship in Arterial and Mixed Venous Blood. Journal Of Applied Physiology 2001, 91: 2412-2414. PMID: 11706820, DOI: 10.1152/jappl.2001.91.5.2412.
- Sun X, Hansen J, Oudiz R, Wasserman K. Exercise Pathophysiology in Patients With Primary Pulmonary Hypertension. Circulation 2001, 104: 429-435. PMID: 11468205, DOI: 10.1161/hc2901.093198.
- Sun X, Hansen J, Stringer W, Ting H, Wasserman K. Carbon dioxide pressure-concentration relationship in arterial and mixed venous blood during exercise. Journal Of Applied Physiology 2001, 90: 1798-1810. PMID: 11299270, DOI: 10.1152/jappl.2001.90.5.1798.
- Ting H, Sun X, Chuang M, Lewis D, Hansen J, Wasserman K. A Noninvasive Assessment of Pulmonary Perfusion Abnormality in Patients With Primary Pulmonary Hypertension. Chest 2001, 119: 824-832. PMID: 11243964, DOI: 10.1378/chest.119.3.824.
- Sun X, Hansen J, Ting H, Chuang M, Stringer W, Adame D, Wasserman K. Comparison of Exercise Cardiac Output by the Fick Principle Using Oxygen and Carbon Dioxide*. Chest 2000, 118: 631-640. PMID: 10988183, DOI: 10.1378/chest.118.3.631.
- KOROTZER B, ONG S, HANSEN J. Ethnic Differences in Pulmonary Function in Healthy Nonsmoking Asian-Americans and European-Americans. American Journal Of Respiratory And Critical Care Medicine 2000, 161: 1101-1108. PMID: 10764297, DOI: 10.1164/ajrccm.161.4.9902063.
- Chuang M, Ting H, Otsuka T, Sun X, Chiu F, Beaver W, Hansen J, Lewis D, Wasserman K. Aerobically generated CO2stored during early exercise. Journal Of Applied Physiology 1999, 87: 1048-1058. PMID: 10484576, DOI: 10.1152/jappl.1999.87.3.1048.
- Hansen J, Wasserman K. Exercise Testing in Patients With Interstitial Lung Disease. Chest 1998, 113: 1148. PMID: 9554672, DOI: 10.1378/chest.113.4.1148.
- Hansen J, Casaburi R. Patterns of Dissimilarities Among Instrument Models in Measuring Po2, Pco2, and pH in Blood Gas Laboratories. Chest 1998, 113: 780-787. PMID: 9515857, DOI: 10.1378/chest.113.3.780.
- Stringer W, Hansen J, Wasserman K. Cardiac output estimated noninvasively from oxygen uptake during exercise. Journal Of Applied Physiology 1997, 82: 908-912. PMID: 9074981, DOI: 10.1152/jappl.1997.82.3.908.
- Hansen J, Wasserman K. Pathophysiology of Activity Limitation in Patients With Interstitial Lung Disease. Chest 1996, 109: 1566-1576. PMID: 8769513, DOI: 10.1378/chest.109.6.1566.
- A Statistical Approach for Assessment of Bronchodilator Responsiveness in Pulmonary Function TestingHansen J, Casaburi R, Goldberg A. A Statistical Approach for Assessment of Bronchodilator Responsiveness in Pulmonary Function Testing. Chest 1993, 104: 1119-1126. PMID: 8404178, DOI: 10.1378/chest.104.4.1119.
- Hansen J. Participant Responses to Blood Gas Proficiency Testing Reports. Chest 1992, 101: 1240-1244. PMID: 1582278, DOI: 10.1378/chest.101.5.1240.
- Hansen J, Casaburi R, Crapo R, Jensen R. Assessing Precision and Accuracy in Blood Gas Proficiency Testing: Reply. American Journal Of Respiratory And Critical Care Medicine 1992, 145: 498-498. DOI: 10.1164/ajrccm/145.2_pt_1.498-a.
- Hansen J, Casaburi R, Crapo R, Jensen R. Assessing Precision and Accuracy in Blood Gas Proficiency Testing. American Journal Of Respiratory And Critical Care Medicine 1990, 141: 1190-1193. PMID: 2111104, DOI: 10.1164/ajrccm/141.5_pt_1.1190.
- Hansen J. Diet and flight hypoxemia. Annals Of Internal Medicine 1989, 111: 859-60. PMID: 2817638, DOI: 10.7326/0003-4819-111-10-859_2.
- Casaburi R, Daly J, Hansen J, Effros R. Abrupt changes in mixed venous blood gas composition after the onset of exercise. Journal Of Applied Physiology 1989, 67: 1106-1112. PMID: 2507504, DOI: 10.1152/jappl.1989.67.3.1106.
- Hansen J, Jensen R, Casaburi R, Crapo R. Comparison of Blood Gas Analyzer Biases in Measuring Tonometered Blood and a Fluorocarbon-containing, Proficiency-testing Material. American Journal Of Respiratory And Critical Care Medicine 1989, 140: 403-409. PMID: 2504088, DOI: 10.1164/ajrccm/140.2.403.
- Hansen J. Arterial Blood Gases. Clinics In Chest Medicine 1989, 10: 227-237. PMID: 2661120, DOI: 10.1016/s0272-5231(21)00624-9.
- Hansen J, Feil M. Blood Gas Quality Control Materials Compered to Tonometered Blood in Examining for Interinstrument Bias in Po2. Chest 1988, 94: 49-54. PMID: 3383656, DOI: 10.1378/chest.94.1.49.
- ROBINSON T, SUE D, HUSZCZUK A, WEILER-RAVELL D, HANSEN J. Infra-arterial arid cuff blood pressure responses during incremental cycle ergometry. Medicine & Science In Sports & Exercise 1988, 20: 142. DOI: 10.1249/00005768-198804001-00007.
- Hansen J, Casaburi R, Cooper D, Wasserman K. Oxygen uptake as related to work rate increment during cycle ergometer exercise. European Journal Of Applied Physiology 1988, 57: 140-145. PMID: 3349978, DOI: 10.1007/bf00640653.
- Baber S, Laks M, Hansen J, Selvester R. Effects of pulmonary emphysema on QRS infarct size score. Journal Of Electrocardiology 1988, 21: s112-s116. PMID: 3216165, DOI: 10.1016/0022-0736(88)90070-2.
- Robinson T, Sue D, Huszczuk A, Weiler-Ravell D, Hansen J. Intra-arterial and cuff blood pressure responses during incremental cycle ergometry. Medicine & Science In Sports & Exercise 1988, 20: 142-9. PMID: 3367749, DOI: 10.1249/00005768-198820020-00007.
- Sue D, Oren A, Hansen J, Wasserman K. Diffusing Capacity for Carbon Monoxide as a Predictor of Gas Exchange during Exercise. The New England Journal Of Medicine 1987, 316: 1301-1306. PMID: 3574401, DOI: 10.1056/nejm198705213162103.
- Wasserman K, Hansen J, Sue D, Whipp B, Froelicher V. Principles of Exercise Testing and Interpretation. Journal Of Cardiopulmonary Rehabilitation And Prevention 1987, 7: 189. DOI: 10.1097/00008483-198704000-00014.
- Hansen J, Sue D, Oren A, Wasserman K. Relation of oxygen uptake to work rate in normal men and men with circulatory disorders. The American Journal Of Cardiology 1987, 59: 669-674. PMID: 3825911, DOI: 10.1016/0002-9149(87)91190-8.
- Hansen J, Casaburi R. Validity of Ear Oximetry in Clinical Exercise Testing. Chest 1987, 91: 333-337. PMID: 3816311, DOI: 10.1378/chest.91.3.333.
- Oren A, Sue D, Hansen J, Torrance D, Wasserman K. The Role of Exercise Testing in Impairment Evaluation. American Journal Of Respiratory And Critical Care Medicine 1987, 135: 230-235. PMID: 3800148, DOI: 10.1164/arrd.1987.135.1.230.
- Ben-Dov I, Sue D, Hansen J, Wasserman K. Bronchodilatation and Attenuation of Exercise-Induced Bronchospasm by PY 108−068, a New Calcium Antagonist. American Journal Of Respiratory And Critical Care Medicine 1986, 133: 116-119. PMID: 3942368, DOI: 10.1164/arrd.1986.133.1.116.
- Olive S, Hansen J, Sue D, Ben-Dov I, Wasserman K. Comparison of PY 108-068, a New Calcium Antagonist, with Nifedipine in Exercise-Induced Asthma. Chest 1986, 90: 208-211. PMID: 3525023, DOI: 10.1378/chest.90.2.208.
- Hansen J, Clausen J, Levy S, Mohler J, Van Kessel A. Proficiency Testing Materials for pH and Blood Gases The California Thoracic Society Experience. Chest 1986, 89: 214-217. PMID: 3943381, DOI: 10.1378/chest.89.2.214.
- Sue D, Oren A, Hansen J, Wasserman K. Lung Function and Exercise Performance in Smoking and Nonsmoking Asbestos-exposed Workers. American Journal Of Respiratory And Critical Care Medicine 1985, 132: 612-618. PMID: 4037534, DOI: 10.1164/arrd.1985.132.3.612.
- Hirsch G, Sue D, Wasserman K, Robinson T, Hansen J. Immediate effects of cigarette smoking on cardiorespiratory responses to exercise. Journal Of Applied Physiology 1985, 58: 1975-1981. PMID: 4008417, DOI: 10.1152/jappl.1985.58.6.1975.
- Hansen J. Alcohol Consumption and Emphysema. Chest 1984, 86: 804. PMID: 6488933, DOI: 10.1378/chest.86.5.804-a.
- Sue D, Hansen J. Normal Values in Adults During Exercise Testing. Clinics In Chest Medicine 1984, 5: 89-98. PMID: 6723246, DOI: 10.1016/s0272-5231(21)00234-3.
- Hansen J, Sue D, Wasserman K. Predicted Values for Clinical Exercise Testing. American Journal Of Respiratory And Critical Care Medicine 1984, 129: s49-s55. PMID: 6421218, DOI: 10.1164/arrd.1984.129.2p2.s49.
- Buchfuhrer M, Hansen J, Robinson T, Sue D, Wasserman K, Whipp B. Optimizing the exercise protocol for cardiopulmonary assessment. Journal Of Applied Physiology 1983, 55: 1558-1564. PMID: 6643191, DOI: 10.1152/jappl.1983.55.5.1558.
- Ray C, Sue D, Bray G, Hansen J, Wasserman K. Effects of Obesity on Respiratory Function. American Journal Of Respiratory And Critical Care Medicine 1983, 128: 501-506. PMID: 6614644, DOI: 10.1164/arrd.1983.128.3.501.
- Sue D, Van Meter L, Hansen J, Wasserman K. Exercise gas exchange in asthmatics after beta-adrenergic blockade. Journal Of Applied Physiology 1983, 55: 529-533. PMID: 6137468, DOI: 10.1152/jappl.1983.55.2.529.
- Nery L, Wasserman K, Andrews J, Huntsman D, Hansen J, Whipp B. Ventilatory and gas exchange kinetics during exercise in chronic airways obstruction. Journal Of Applied Physiology 1982, 53: 1594-1602. PMID: 6818216, DOI: 10.1152/jappl.1982.53.6.1594.
- Furuike A, Sue D, Hansen J, Wasserman K. Comparison of Physiologic Dead Space/Tidal Volume Ratio and Alveolar-Arterial PO2 Difference During Incremental and Constant Work Exercise. American Journal Of Respiratory And Critical Care Medicine 1982, 126: 579-583. PMID: 7125348, DOI: 10.1164/arrd.1982.126.3.579.
- Sue D, Hansen J, Wasserman K. The value of exercise in testing beta blockade and airway reactivity in asthmatic patients. American Heart Journal 1982, 104: 442-445. PMID: 7102529, DOI: 10.1016/0002-8703(82)90137-5.
- Hansen J, Stone M, Ong S, Van Kessel A. Evaluation of Blood Gas Quality Control and Proficiency Testing Materials by Tonometry. American Journal Of Respiratory And Critical Care Medicine 1982, 125: 480-483. PMID: 7073119, DOI: 10.1164/arrd.1982.125.4.480.
- Sue D, Hansen J, Wasserman K. Beta-Adrenergic Blockade with Pindolol (LB-46) in Mild to Moderate Asthma. Chest 1981, 80: 537-542. PMID: 7297143, DOI: 10.1378/chest.80.5.537.
- Sue D, Hansen J, Blais M, Wasserman K. Measurement and analysis of gas exchange during exercise using a programmable calculator. Journal Of Applied Physiology 1980, 49: 456-461. PMID: 6782049, DOI: 10.1152/jappl.1980.49.3.456.
- Hansen J, Sue D. Should Blood Gas Measurements Be Corrected for the Patient's Temperature? The New England Journal Of Medicine 1980, 303: 341. PMID: 7383135, DOI: 10.1056/nejm198008073030616.
- Schiffman P, Ryan A, Whipp B, Hansen J, Wasserman K. Hyperoxic attenuation of exercise-induced bronchospasm in asthmatics. Journal Of Clinical Investigation 1979, 63: 30-37. PMID: 762245, PMCID: PMC371914, DOI: 10.1172/jci109274.
- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Yale Therapeutic RadiologyHunter Building15 York StreetNew Haven, CT 06510
Biography
James E. Hansen, MD, is a therapeutic radiologist who specializes in treating a variety of conditions, including brain tumors, head and neck cancers, lung cancer, lymphoma, skin cancer, and cancers of the gastrointestinal and genitourinary systems.
Dr. Hansen employs advanced techniques such as stereotactic radiosurgery and stereotactic body radiation therapy to target tumors precisely while minimizing damage to surrounding healthy tissue. He is committed to finding the right balance between effective treatment and protecting normal organ function, especially in patients with brain tumors.
“Every patient journey is unique. Please know that in good times or challenging times, you are never battling this disease alone,” Dr. Hansen says. As an associate professor of therapeutic radiology at Yale School of Medicine, Dr. Hansen's research explores how certain autoantibodies—molecules generated in autoimmune disorders—might be harnessed to fight cancer.
Dr. Hansen is particularly excited about advancements in drug design that allow treatments to cross the blood-brain barrier, offering new hope for brain tumor patients. “I have never been more excited and optimistic about the future benefits of therapies that cross the blood-brain barrier and target brain tumors,” he explains. Dr. Hansen completed his medical training at UCLA School of Medicine, followed by a residency and chief residency in therapeutic radiology at Yale School of Medicine.
Titles
- Associate Professor of Therapeutic Radiology
- Chief, Gamma Knife Program, Therapeutic Radiology
- Radiation Safety, Therapeutic Radiology
- Co-Director, Stereotactic Radiosurgery and Body Radiotherapy Fellowship, Therapeutic Radiology
Education & Training
- Chief ResidentYale School of Medicine (2012)
- ResidentYale School of Medicine (2011)
- Postdoctoral ScholarUCLA (2007)
- MDUCLA School of Medicine (2004)
- MSUniversity of California, Los Angeles, Biochemistry and Molecular Biology (1999)
Additional Information
- AB of Radiology, Radiation Oncology (2013)
- Chung A, Ghankot R, Li D, Omiunu A, Singh M, Jester N, Tommasini S, Hansen J, Chiang V, Buono F, Mahajan A, Schwartz N. Volumetric Assessment of Vestibular Schwannomas Exhibiting Internal Growth After Stereotactic Radiosurgery: Application of Artificial Intelligence. Clinical Neuroradiology 2026, 1-11. PMID: 42584671, DOI: 10.1007/s00062-026-01707-8.
- Becht K, Lindsay M, Soulos P, Singh C, Hansen J, An Y, Aneja S, Goldberg S, Chiang V, Park H. Disparities in stereotactic radiosurgery receipt in patients with brain metastases from non-small cell lung cancer. Journal Of Neuro-Oncology 2026, 177: 151. PMID: 42141140, DOI: 10.1007/s11060-026-05615-2.
- Robert S, Hansen J, Chiang V. Recognition and Management of Adverse Radiation Effects. 2026, 362-374. DOI: 10.1201/9781003649335-35.
- Jin Y, Cao F, Xie Y, Davis S, Dong G, Nigwekar S, Hansen J, Guzman R, Cai Y. High Phosphate and Low Protein Mediate Arterial and Cutaneous Vascular Calcification in CKD Mice. Journal Of The American Society Of Nephrology 2025, 37: 683-699. PMID: 40960881, PMCID: PMC12448113, DOI: 10.1681/asn.0000000875.
- Chen X, Tang X, Xie Y, Cuffari B, Tang C, Cao F, Gao X, Meng Z, Noble P, Young M, Turk O, Shirali A, Gera J, Nishimura R, Zhou J, Hansen J. A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells. Science Signaling 2025, 18: eadk3320-eadk3320. PMID: 40132052, PMCID: PMC12076517, DOI: 10.1126/scisignal.adk3320.
- Cao F, Tang C, Chen X, Tu Z, Jin Y, Turk O, Nishimura R, Ebens A, Dubljevic V, Campbell J, Zhou J, Hansen J. Cathepsin B Nuclear Flux in a DNA-Guided “Antinuclear Missile” Cancer Therapy. ACS Central Science 2024, 10: 1562-1572. PMID: 39220699, PMCID: PMC11363321, DOI: 10.1021/acscentsci.4c00559.
- May C, Noble P, Herzog E, Meffre E, Hansen J. Nuclear-penetrating scleroderma autoantibody inhibits topoisomerase 1 cleavage complex formation. Biochemical And Biophysical Research Communications 2024, 720: 150123. PMID: 38759301, DOI: 10.1016/j.bbrc.2024.150123.
- Hino C, Chan G, Jordaan G, Chang S, Saunders J, Bashir M, Hansen J, Gera J, Weisbart R, Nishimura R. Cellular protection from H2O2 toxicity by Fv-Hsp70: protection via catalase and gamma-glutamyl-cysteine synthase. Cell Stress And Chaperones 2023, 28: 429-439. PMID: 37171750, PMCID: PMC10352194, DOI: 10.1007/s12192-023-01349-6.
- Draeger E, Chen Z, Hansen J, Chiang V, Tien C. Preliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems. Journal Of Applied Clinical Medical Physics 2023, 24: e13907. PMID: 36660774, PMCID: PMC10161057, DOI: 10.1002/acm2.13907.
- Chen X, Cuffari BJ, Dubljevic V, Shirali A, Zhou J, Campbell JA, Suits SC, O'Sullivan KM, Hansen JE. Inhibition of NETosis by a Nuclear-Penetrating Anti-DNA Autoantibody. ImmunoHorizons 2022, 6: 356-365. PMID: 35697479, DOI: 10.4049/immunohorizons.2100091.
- Glauzy S, Olson B, May CK, Parisi D, Massad C, Hansen JE, Ryu C, Herzog EL, Meffre E. Defective Early B Cell Tolerance Checkpoints in Patients With Systemic Sclerosis Allow the Production of Self Antigen–Specific Clones. Arthritis & Rheumatology 2021, 74: 307-317. PMID: 34279059, PMCID: PMC8766600, DOI: 10.1002/art.41927.
- Cheok S, Hansen J, Chiang V. Recognition and Management of Adverse Radiation Effects. 2021, 391-404. DOI: 10.1201/9781003167464-36.
- Rattray Z, Deng G, Zhang S, Shirali A, May CK, Chen X, Cuffari BJ, Liu J, Zou P, Rattray N, Johnson CH, Dubljevic V, Campbell JA, Huttner A, Baehring JM, Zhou J, Hansen JE. ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody. JCI Insight 2021, 6: e145875. PMID: 34128837, PMCID: PMC8410084, DOI: 10.1172/jci.insight.145875.
- Peters GW, Tien CJ, Chiang V, Yu J, Hansen JE, Aneja S. Impact of tissue heterogeneity correction on Gamma Knife stereotactic radiosurgery of acoustic neuromas. Journal Of Radiosurgery And SBRT 2021, 7: 207-212. PMID: 33898084, PMCID: PMC8055239.
- Ladouceur A, Tissera H, Clarke A, Ramsey-Goldman R, Gordon C, Hansen J, Bernatsky S. Chapter 48 Malignancies in systemic lupus erythematosus. 2021, 461-467. DOI: 10.1016/b978-0-12-814551-7.00048-9.
- Chen Y, Jiang T, Zhang H, Gou X, Han C, Wang J, Chen AT, Ma J, Liu J, Chen Z, Jing X, Lei H, Wang Z, Bao Y, Baqri M, Zhu Y, Bindra RS, Hansen JE, Dou J, Huang C, Zhou J. LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy. Nature Cell Biology 2020, 22: 1276-1285. PMID: 33005030, PMCID: PMC7962994, DOI: 10.1038/s41556-020-00586-6.
- Miccio JA, Barsky A, Gao S, Verma V, Noticewala SS, Jairam V, Johnson SB, Yu JB, Hansen JE, Aneja S, An Y, Decker RH, Bulent Omay S, Li J, Kurtz GA, Alonso-Basanta M, Lee JYK, Chiang VL, Park HS. Multi-institutional retrospective review of stereotactic radiosurgery for brain metastasis in patients with small cell lung cancer without prior brain-directed radiotherapy. Journal Of Radiosurgery And SBRT 2020, 7: 19-27. PMID: 32802575, PMCID: PMC7406345.
- Hansen J, Dilektasli A, Porszasz J, Stringer W, Pak Y, Rossiter H, Casaburi R. A New Bronchodilator Response Grading Strategy Identifies Distinct Patient Populations. Annals Of The American Thoracic Society 2019, 16: 1504-1517. PMID: 31404502, PMCID: PMC6956832, DOI: 10.1513/annalsats.201901-030oc.
- Yu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Mahajan A, Omay S, Chiang V. Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials. Journal Of Radiation Oncology 2019, 8: 39-46. DOI: 10.1007/s13566-018-0370-7.
- Isenberg D, Giles I, Hansen J, Rahman A. 27 Antinuclear Antibodies, Antibodies to DNA, Histones, and Nucleosomes. 2019, 355-365. DOI: 10.1016/b978-0-323-47927-1.00027-x.
- Kim C, Van Iterson E, Hansen J, MacCarter D, Johnson B. Streamlining cardiopulmonary exercise testing for use as a screening and tracking tool in primary care. Pulmonary Circulation 2018, 8: 1-8. PMID: 29693481, PMCID: PMC5987906, DOI: 10.1177/2045894018776489.
- Loganadane G, Kelly JR, Lee NC, Kann BH, Mahajan A, Hansen JE, Belkacémi Y, Yarbrough W, Husain ZA. Incidence of radiographically occult nodal metastases in HPV+ oropharyngeal carcinoma: Implications for reducing elective nodal coverage. Practical Radiation Oncology 2018, 8: 397-403. PMID: 29730282, DOI: 10.1016/j.prro.2018.03.009.
- Tan C, Rossiter H, Porszasz J, Bowen T, Witte K, Stringer W, Casaburi R, Hansen J. Reliability and Physiological Interpretation of Pulmonary Gas Exchange by “Circulatory Equivalents” in Chronic Heart Failure. Journal Of The American Heart Association 2018, 7: e008072. PMID: 29588313, PMCID: PMC5907590, DOI: 10.1161/jaha.117.008072.
- Rattray Z, Dubljevic V, Rattray NJW, Greenwood DL, Johnson CH, Campbell JA, Hansen JE. Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications. Biochemical And Biophysical Research Communications 2018, 496: 858-864. PMID: 29374508, DOI: 10.1016/j.bbrc.2018.01.139.
- Bernatsky S, Ramsey-Goldman R, Petri M, Urowitz MB, Gladman DD, Fortin PR, Yelin EH, Ginzler E, Hanly JG, Peschken C, Gordon C, Nived O, Aranow C, Bae SC, Isenberg D, Rahman A, Hansen JE, Pierre Y, Clarke AE. Smoking Is the Most Significant Modifiable Lung Cancer Risk Factor in Systemic Lupus Erythematosus. The Journal Of Rheumatology 2018, 45: 393-396. PMID: 29335347, PMCID: PMC5834350, DOI: 10.3899/jrheum.170652.
- Johnson CH, Santidrian AF, LeBoeuf SE, Kurczy ME, Rattray NJW, Rattray Z, Warth B, Ritland M, Hoang LT, Loriot C, Higa J, Hansen JE, Felding BH, Siuzdak G. Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids. Cancer & Metabolism 2017, 5: 9. PMID: 29093815, PMCID: PMC5663111, DOI: 10.1186/s40170-017-0171-2.
- Kim C, Hansen J, Anderson D, McCarter D, Anderson S, Johnson B. Algorithm For Predicting Disease Likelihood From Noninvasive Submaximal Cardiopulmonary Exercise Testing. Medicine & Science In Sports & Exercise 2017, 49: 408. DOI: 10.1249/01.mss.0000517998.06927.d0.
- Rattray NJW, Charkoftaki G, Rattray Z, Hansen JE, Vasiliou V, Johnson CH. Environmental Influences in the Etiology of Colorectal Cancer: the Premise of Metabolomics. Current Pharmacology Reports 2017, 3: 114-125. PMID: 28642837, PMCID: PMC5475285, DOI: 10.1007/s40495-017-0088-z.
- Kim C, Hansen J, MacCarter D, Johnson B. Algorithm for Predicting Disease Likelihood From a Submaximal Exercise Test. Therapeutic Advances In Pulmonary And Critical Care Medicine 2017, 11: 1179548417719248. PMID: 28757799, PMCID: PMC5513526, DOI: 10.1177/1179548417719248.
- Bernatsky S, Ramsey-Goldman R, Petri M, Urowitz MB, Gladman DD, Fortin P, Ginzler E, Romero-Diaz J, Peschken C, Jacobsen S, Hanly JG, Gordon C, Nived O, Yelin EH, Isenberg D, Rahman A, Bae SC, Joseph L, Witte T, Ruiz-Irastorza G, Aranow C, Kamen D, Sturfeldt G, Foulkes WD, Hansen JE, St Pierre Y, Raymer PC, Tessier-Cloutier B, Clarke AE. Breast cancer in systemic lupus. Lupus 2016, 26: 311-315. PMID: 27687028, PMCID: PMC5250552, DOI: 10.1177/0961203316664595.
- Chen Z, Patel JM, Noble PW, Garcia C, Hong Z, Hansen JE, Zhou J. A lupus anti-DNA autoantibody mediates autocatalytic, targeted delivery of nanoparticles to tumors. Oncotarget 2016, 7: 59965-59975. PMID: 27494868, PMCID: PMC5312362, DOI: 10.18632/oncotarget.11015.
- Dilektasli A, Porszasz J, Casaburi R, Stringer W, Bhatt S, Pak Y, Rossiter H, Washko G, Castaldi P, San Jose Estepar R, Hansen J, investigators C. A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria. Chest 2016, 150: 1080-1090. PMID: 27452770, PMCID: PMC5103018, DOI: 10.1016/j.chest.2016.06.047.
- Noble PW, Bernatsky S, Clarke AE, Isenberg DA, Ramsey-Goldman R, Hansen JE. DNA-damaging autoantibodies and cancer: the lupus butterfly theory. Nature Reviews Rheumatology 2016, 12: 429-434. PMID: 27009542, DOI: 10.1038/nrrheum.2016.23.
- Tissera H, Clarke A, Goldman R, Gordon C, Hansen J, Bernatsky S. Chapter 46 Malignancies in Systemic Lupus Erythematosus. 2016, 411-415. DOI: 10.1016/b978-0-12-801917-7.00046-2.
- Yao Y, Sun X, Zheng Z, Wang G, Hansen J, Stringer W, Wasserman K, Hu S. Better parameters of ventilation-CO₂output relationship predict death in CHF patients. Chinese Journal Of Applied Physiology 2015, 31: 508-16. PMID: 27215018.
- Weisbart RH, Chan G, Jordaan G, Noble PW, Liu Y, Glazer PM, Nishimura RN, Hansen JE. DNA-dependent targeting of cell nuclei by a lupus autoantibody. Scientific Reports 2015, 5: 12022. PMID: 26156563, PMCID: PMC4496662, DOI: 10.1038/srep12022.
- Noble PW, Chan G, Young MR, Weisbart RH, Hansen JE. Optimizing a Lupus Autoantibody for Targeted Cancer Therapy. Cancer Research 2015, 75: 2285-2291. PMID: 25832653, DOI: 10.1158/0008-5472.can-14-2278.
- Hansen J, Porszasz J. Rebuttal From Drs Hansen and Porszasz. Chest 2014, 146: 542-544. PMID: 25180720, DOI: 10.1378/chest.14-0618.
- Hansen J, Porszasz J. Counterpoint: Is an Increase in FEV1 and/or FVC ≥ 12% of Control and ≥ 200 mL the Best Way to Assess Positive Bronchodilator Response? No. Chest 2014, 146: 538-541. PMID: 25180718, DOI: 10.1378/chest.14-0437.
- Noble PW, Young MR, Bernatsky S, Weisbart RH, Hansen JE. A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells. Scientific Reports 2014, 4: 5958. PMID: 25091037, PMCID: PMC5380011, DOI: 10.1038/srep05958.
- Tessier-Cloutier B, Clarke AE, Ramsey-Goldman R, Gordon C, Hansen JE, Bernatsky S. Systemic Lupus Erythematosus and Malignancies A Review Article. Rheumatic Disease Clinics Of North America 2014, 40: 497-506. PMID: 25034158, DOI: 10.1016/j.rdc.2014.04.005.
- Hansen J, Porszasz J, Casaburi R, Stringer W. Re-Defining Lower Limit of Normal for FEV1/FEV6, FEV1/FVC, FEV3/FEV6 and FEV3/FVC to Improve Detection of Airway Obstruction. Chronic Obstructive Pulmonary Diseases Journal Of The COPD Foundation 2014, 2: 94-102. PMID: 28848835, PMCID: PMC5556964, DOI: 10.15326/jcopdf.2.2.2014.0144.
- Hansen J. Human Lung Acinar Structure and Function Are Even Better than Good. American Journal Of Respiratory And Critical Care Medicine 2013, 188: 623-623. PMID: 23992592, DOI: 10.1164/rccm.201302-0405le.
- Cloutier B, Clarke AE, Ramsey-Goldman R, Wang Y, Foulkes W, Gordon C, Hansen JE, Yelin E, Urowitz MB, Gladman D, Fortin PR, Wallace DJ, Petri M, Manzi S, Ginzler EM, Labrecque J, Edworthy S, Dooley MA, Senécal JL, Peschken CA, Bae SC, Isenberg D, Rahman A, Ruiz-Irastorza G, Hanly JG, Jacobsen S, Nived O, Witte T, Criswell LA, Barr SG, Dreyer L, Sturfelt G, Bernatsky S, Clinics S. Breast Cancer in Systemic Lupus Erythematosus. Oncology 2013, 85: 117-121. PMID: 23887245, PMCID: PMC3934367, DOI: 10.1159/000353138.
- Gläser S, Ittermann T, Koch B, Schäper C, Felix S, Völzke H, Könemann R, Ewert R, Hansen J. Influence of smoking and obesity on alveolar-arterial gas pressure differences and dead space ventilation at rest and peak exercise in healthy men and women. Respiratory Medicine 2013, 107: 919-926. PMID: 23510666, DOI: 10.1016/j.rmed.2013.02.013.
- Hansen J. Hooray for the Va/TLC and DlCO/Va. American Journal Of Respiratory And Critical Care Medicine 2013, 187: 107-107. PMID: 23281352, DOI: 10.1164/ajrccm.187.1.107.
- Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH, Glazer PM. Targeting Cancer with a Lupus Autoantibody. Science Translational Medicine 2012, 4: 157ra142. PMID: 23100628, PMCID: PMC3713477, DOI: 10.1126/scitranslmed.3004385.
- Weisbart RH, Gera JF, Chan G, Hansen JE, Li E, Cloninger C, Levine AJ, Nishimura RN. A Cell-Penetrating Bispecific Antibody for Therapeutic Regulation of Intracellular Targets. Molecular Cancer Therapeutics 2012, 11: 2169-2173. PMID: 22863609, DOI: 10.1158/1535-7163.mct-12-0476-t.
- Hansen J, Sun X, Stringer W. A Simple New Visualization of Exercise Data Discloses Pathophysiology and Severity of Heart Failure. Journal Of The American Heart Association 2012, 1: e001883. PMID: 23130146, PMCID: PMC3487328, DOI: 10.1161/jaha.112.001883.
- Hansen J. Has My Patient Responded? American Journal Of Respiratory And Critical Care Medicine 2012, 185: 895-895. PMID: 22505756, DOI: 10.1164/ajrccm.185.8.895.
- Hansen J. A Better Way to Assess Bronchoreversibility. Chest 2012, 141: 1118. PMID: 22474156, DOI: 10.1378/chest.11-2705.
- Sun X, Hansen J, Stringer W. Oxygen Uptake Efficiency Plateau Best Predicts Early Death in Heart Failure. Chest 2011, 141: 1284-1294. PMID: 22030802, PMCID: PMC4694089, DOI: 10.1378/chest.11-1270.
- Sun X, Hansen J, Stringer W. Oxygen uptake efficiency plateau: physiology and reference values. European Journal Of Applied Physiology 2011, 112: 919-928. PMID: 21695524, DOI: 10.1007/s00421-011-2030-0.
- Hansen J. Lower Limit of Normal Is Better Than 70% or 80%. Chest 2011, 139: 6-8. PMID: 21208872, DOI: 10.1378/chest.10-1117.
- Dumitrescu D, Oudiz R, Karpouzas G, Hovanesyan A, Jayasinghe A, Hansen J, Rosenkranz S, Wasserman K. Developing Pulmonary Vasculopathy in Systemic Sclerosis, Detected with Non-Invasive Cardiopulmonary Exercise Testing. PLOS ONE 2010, 5: e14293. PMID: 21179195, PMCID: PMC3001444, DOI: 10.1371/journal.pone.0014293.
- Hansen J. Lung age is a useful concept and calculation. Npj Primary Care Respiratory Medicine 2010, 19: 400-401. PMID: 21042695, PMCID: PMC6602464, DOI: 10.4104/pcrj.2010.00074.
- Chaudhry S, Arena R, Hansen J, Lewis G, Myers J, Sperling L, LaBudde B, Wasserman K. The Utility of Cardiopulmonary Exercise Testing to Detect and Track Early-Stage Ischemic Heart Disease. Mayo Clinic Proceedings 2010, 85: 928-932. PMID: 20884826, PMCID: PMC2947965, DOI: 10.4065/mcp.2010.0183.
- Hansen J. Assessment of bronchoreversibility in severe emphysema. European Respiratory Journal 2010, 36: 972-972. PMID: 20889470, DOI: 10.1183/09031936.00070010.
- Hansen J. Measuring the lung age of smokers. Npj Primary Care Respiratory Medicine 2010, 19: 286-287. PMID: 20676592, PMCID: PMC6602245, DOI: 10.4104/pcrj.2010.00048.
- Sven G, Koch B, Ittermann T, Christoph S, Marcus D, Felix S, Henry V, Ewert R, Hansen J. Influence of age, sex, body size, smoking, and β blockade on key gas exchange exercise parameters in an adult population. European Journal Of Preventive Cardiology 2010, 17: 469-476. PMID: 20305565, DOI: 10.1097/hjr.0b013e328336a124.
- Oudiz R, Midde R, Hovanesyan A, Sun X, Roveran G, Hansen J, Wasserman K. Usefulness of Right-to-Left Shunting and Poor Exercise Gas Exchange for Predicting Prognosis in Patients With Pulmonary Arterial Hypertension. The American Journal Of Cardiology 2010, 105: 1186-1191. PMID: 20381675, PMCID: PMC3031421, DOI: 10.1016/j.amjcard.2009.12.024.
- Sun X, Hansen J, Beshai J, Wasserman K. Oscillatory Breathing and Exercise Gas Exchange Abnormalities Prognosticate Early Mortality and Morbidity in Heart Failure. Journal Of The American College Of Cardiology 2010, 55: 1814-1823. PMID: 20413031, DOI: 10.1016/j.jacc.2009.10.075.
- Zhan X, Ander BP, Liao IH, Hansen JE, Kim C, Clements D, Weisbart RH, Nishimura RN, Sharp FR. Recombinant Fv-Hsp70 Protein Mediates Neuroprotection After Focal Cerebral Ischemia in Rats. Stroke 2010, 41: 538-543. PMID: 20075343, PMCID: PMC2957177, DOI: 10.1161/strokeaha.109.572537.
- Hansen J, Sun X, Wasserman K. Calculating gambling odds and lung ages for smokers. European Respiratory Journal 2009, 35: 776-780. PMID: 19797127, DOI: 10.1183/09031936.00107709.
- Heinze E, Baldwin S, Chan G, Hansen J, Song J, Clements D, Aragon R, Nishimura R, Reeves M, Weisbart R. Antibody-mediated FOXP3 protein therapy induces apoptosis in cancer cells in vitro and inhibits metastasis in vivo. International Journal Of Oncology 2009, 35: 167-73. PMID: 19513564, DOI: 10.3892/ijo_00000325.
- Chaudhry S, Arena R, Wasserman K, Hansen J, Lewis G, Myers J, Belardinelli R, LaBudde B, Menasco N, Boden W. The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia. International Journal Of Cardiology 2009, 148: e7-e9. PMID: 19233492, PMCID: PMC3062706, DOI: 10.1016/j.ijcard.2009.01.055.
- Robbins J, Duscha B, Bensimhon D, Wasserman K, Hansen J, Houmard J, Annex B, Kraus W. A sex-specific relationship between capillary density and anaerobic threshold. Journal Of Applied Physiology 2009, 106: 1181-1186. PMID: 19164774, PMCID: PMC2698638, DOI: 10.1152/japplphysiol.90947.2008.
- Chaudhry S, Arena R, Wasserman K, Hansen J, Lewis G, Myers J, Chronos N, Boden W. Exercise-Induced Myocardial Ischemia Detected by Cardiopulmonary Exercise Testing. The American Journal Of Cardiology 2009, 103: 615-619. PMID: 19231322, PMCID: PMC3035935, DOI: 10.1016/j.amjcard.2008.10.034.
- Hansen J. Assessing small airways disease. European Respiratory Journal 2008, 32: 1410-1410. PMID: 18978142, DOI: 10.1183/09031936.00088908.
- Hansen J, Sun X, Adame D, Wasserman K. Argument for changing criteria for bronchodilator responsiveness. Respiratory Medicine 2008, 102: 1777-1783. PMID: 18701269, DOI: 10.1016/j.rmed.2008.06.019.
- Ma QL, Yang F, Calon F, Ubeda OJ, Hansen JE, Weisbart RH, Beech W, Frautschy SA, Cole GM. p21-activated Kinase-aberrant Activation and Translocation in Alzheimer Disease Pathogenesis*. Journal Of Biological Chemistry 2008, 283: 14132-14143. PMID: 18347024, PMCID: PMC2376243, DOI: 10.1074/jbc.m708034200.
- Oudiz R, Roveran G, Hansen J, Sun X, Wasserman K. Effect of sildenafil on ventilatory efficiency and exercise tolerance in pulmonary hypertension. European Journal Of Heart Failure 2007, 9: 917-921. PMID: 17707133, PMCID: PMC2071948, DOI: 10.1016/j.ejheart.2007.06.013.
- Hansen J, Ulubay G, Chow B, Sun X, Wasserman K. Mixed-Expired and End-Tidal CO2 Distinguish Between Ventilation and Perfusion Defects During Exercise Testing in Patients With Lung and Heart Diseases. Chest 2007, 132: 977-983. PMID: 17573506, DOI: 10.1378/chest.07-0619.
- Hansen J, Sun X, Wasserman K. Shifting the Goalpost To Stay Younger Normal Spirometry but Short of Breath! Chest 2007, 131: 1990. DOI: 10.1016/s0012-3692(15)37550-4.
- Hansen JE, Tse CM, Chan G, Heinze ER, Nishimura RN, Weisbart RH. Intranuclear Protein Transduction through a Nucleoside Salvage Pathway*. Journal Of Biological Chemistry 2007, 282: 20790-20793. PMID: 17525162, DOI: 10.1074/jbc.c700090200.
- Wasserman K, Sun X, Hansen J. Effect of Biventricular Pacing on the Exercise Pathophysiology of Heart Failure. Chest 2007, 132: 250-261. PMID: 17505041, DOI: 10.1378/chest.06-2872.
- Hansen JE, Fischer LK, Chan G, Chang SS, Baldwin SW, Aragon RJ, Carter JJ, Lilly M, Nishimura RN, Weisbart RH, Reeves ME. Antibody-Mediated p53 Protein Therapy Prevents Liver Metastasis In vivo. Cancer Research 2007, 67: 1769-1774. PMID: 17308119, DOI: 10.1158/0008-5472.can-06-3783.
- Hansen J, Sun X, Wasserman K. Spirometric Criteria for Airway Obstruction Use Percentage of FEV1/FVC Ratio Below the Fifth Percentile, Not < 70%. Chest 2007, 131: 349-355. PMID: 17296632, DOI: 10.1378/chest.06-1349.
- Hansen J, Sun X, Wasserman K. From the authors. European Respiratory Journal 2006, 28: 1289-1290. DOI: 10.1183/09031936.00112706.
- Hansen J, Sun X, Wasserman K. Ethnic- and Sex-free Formulae for Detection of Airway Obstruction. American Journal Of Respiratory And Critical Care Medicine 2006, 174: 493-498. PMID: 16778160, DOI: 10.1164/rccm.200604-517oc.
- Hansen JE, Sohn W, Kim C, Chang SS, Huang NC, Santos DG, Chan G, Weisbart RH, Nishimura RN. Antibody-mediated Hsp70 protein therapy. Brain Research 2006, 1088: 187-196. PMID: 16630585, DOI: 10.1016/j.brainres.2006.03.025.
- Hansen J, Sun X, Wasserman K. Should forced expiratory volume in six seconds replace forced vital capacity to detect airway obstruction? European Respiratory Journal 2006, 27: 1244-1250. PMID: 16455822, DOI: 10.1183/09031936.06.00136905.
- Hansen J, Sun X, Wasserman K. Discriminating Measures and Normal Values for Expiratory Obstruction. Chest 2006, 129: 369-377. PMID: 16478854, DOI: 10.1378/chest.129.2.369.
- Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nature Neuroscience 2006, 9: 234-242. PMID: 16415866, DOI: 10.1038/nn1630.
- Cardiopulmonary Exercise Testing and Six-Minute Walk Correlations in Pulmonary Arterial HypertensionOudiz R, Barst R, Hansen J, Sun X, Garofano R, Wu X, Wasserman K. Cardiopulmonary Exercise Testing and Six-Minute Walk Correlations in Pulmonary Arterial Hypertension. The American Journal Of Cardiology 2005, 97: 123-126. PMID: 16377296, DOI: 10.1016/j.amjcard.2005.07.129.
- Hansen JE, Weisbart RH, Nishimura RN. Antibody Mediated Transduction of Therapeutic Proteins into Living Cells. The Scientific World JOURNAL 2005, 5: 782-788. PMID: 16170440, PMCID: PMC5936519, DOI: 10.1100/tsw.2005.98.
- Wasserman K, Hansen J, Sue D, Stringer W, Whipp B. Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications, 4th Edition. Medicine & Science In Sports & Exercise 2005, 37: 1249. DOI: 10.1249/01.mss.0000172593.20181.14.
- Yasunobu Y, Oudiz R, Sun X, Hansen J, Wasserman K. End-tidal Pco2 Abnormality and Exercise Limitation in Patients With Primary Pulmonary Hypertension. Chest 2005, 127: 1637-1646. PMID: 15888840, DOI: 10.1378/chest.127.5.1637.
- Weisbart RH, Hansen JE, Nishimura RN, Chan G, Wakelin R, Chang SS, Baresi L, Chamberlain JS. An intracellular delivery vehicle for protein transduction of micro-dystrophin. Journal Of Drug Targeting 2005, 13: 81-87. PMID: 15823959, DOI: 10.1080/10611860400029002.
- Weisbart R, Chan G, Wakelin R, Nishimura R, Hansen J, Chang S, Baresi L, Chamberlain J. Development of a Lupus Anti-Dna Antibody as An Intracellular Delivery Vehicle for Protein Transduction of Micro-Dystrophin. Journal Of Investigative Medicine 2005, 53: 129-129. DOI: 10.1177/1081558905053001283.
- Weisbart RH, Hansen JE, Chan G, Wakelin R, Chang SS, Heinze E, Miller CW, Koeffler PH, Yang F, Cole GM, Min YS, Nishimura RN. Antibody-mediated transduction of p53 selectively kills cancer cells. International Journal Of Oncology 2004, 25: 1867-73. PMID: 15547728, DOI: 10.3892/ijo.25.6.1867.
- Hansen J, Sun X, Yasunobu Y, Garafano R, Gates G, Barst R, Wasserman K. Reproducibility of Cardiopulmonary Exercise Measurements in Patients With Pulmonary Arterial Hypertension. Chest 2004, 126: 816-824. PMID: 15364761, DOI: 10.1378/chest.126.3.816.
- Sun X, Hansen J, Oudiz R, Wasserman K. Pulmonary function in primary pulmonary hypertension. Journal Of The American College Of Cardiology 2003, 41: 1028-1035. PMID: 12651053, DOI: 10.1016/s0735-1097(02)02964-9.
- Sun X, Hansen J, Garatachea N, Storer T, Wasserman K. Ventilatory Efficiency during Exercise in Healthy Subjects. American Journal Of Respiratory And Critical Care Medicine 2002, 166: 1443-1448. PMID: 12450934, DOI: 10.1164/rccm.2202033.
- CHUANG M, TING H, OTSUKA T, SUN X, CHIU F, HANSEN J, WASSERMAN K. Muscle deoxygenation as related to work rate. Medicine & Science In Sports & Exercise 2002, 34: 1614-1623. PMID: 12370563, DOI: 10.1097/00005768-200210000-00013.
- Hansen J, Casaburi R. Mitochondrial disorders and exertional intolerance: Controversy continues. American Journal Of Respiratory And Critical Care Medicine 2002, 166: 118-120. PMID: 12091181, DOI: 10.1164/ajrccm.166.1.16611.
- Hansen J. Sarcoidosis and Gas Exchange Measures. Chest 2002, 121: 1004. PMID: 11888995, DOI: 10.1378/chest.121.3.1004.
- Sun X, Hansen J, Oudiz R, Wasserman K. Gas Exchange Detection of Exercise-Induced Right-to-Left Shunt in Patients With Primary Pulmonary Hypertension. Circulation 2002, 105: 54-60. PMID: 11772876, DOI: 10.1161/hc0102.101509.
- Godfrey S, Kazemi H, Systrom D, Wasserman K, Sun X, Hansen J, Ting H, Stringer W. Carbon Dioxide Pressure-Concentration Relationship in Arterial and Mixed Venous Blood. Journal Of Applied Physiology 2001, 91: 2412-2414. PMID: 11706820, DOI: 10.1152/jappl.2001.91.5.2412.
- Sun X, Hansen J, Oudiz R, Wasserman K. Exercise Pathophysiology in Patients With Primary Pulmonary Hypertension. Circulation 2001, 104: 429-435. PMID: 11468205, DOI: 10.1161/hc2901.093198.
- Sun X, Hansen J, Stringer W, Ting H, Wasserman K. Carbon dioxide pressure-concentration relationship in arterial and mixed venous blood during exercise. Journal Of Applied Physiology 2001, 90: 1798-1810. PMID: 11299270, DOI: 10.1152/jappl.2001.90.5.1798.
- Ting H, Sun X, Chuang M, Lewis D, Hansen J, Wasserman K. A Noninvasive Assessment of Pulmonary Perfusion Abnormality in Patients With Primary Pulmonary Hypertension. Chest 2001, 119: 824-832. PMID: 11243964, DOI: 10.1378/chest.119.3.824.
- Sun X, Hansen J, Ting H, Chuang M, Stringer W, Adame D, Wasserman K. Comparison of Exercise Cardiac Output by the Fick Principle Using Oxygen and Carbon Dioxide*. Chest 2000, 118: 631-640. PMID: 10988183, DOI: 10.1378/chest.118.3.631.
- KOROTZER B, ONG S, HANSEN J. Ethnic Differences in Pulmonary Function in Healthy Nonsmoking Asian-Americans and European-Americans. American Journal Of Respiratory And Critical Care Medicine 2000, 161: 1101-1108. PMID: 10764297, DOI: 10.1164/ajrccm.161.4.9902063.
- Chuang M, Ting H, Otsuka T, Sun X, Chiu F, Beaver W, Hansen J, Lewis D, Wasserman K. Aerobically generated CO2stored during early exercise. Journal Of Applied Physiology 1999, 87: 1048-1058. PMID: 10484576, DOI: 10.1152/jappl.1999.87.3.1048.
- Hansen J, Wasserman K. Exercise Testing in Patients With Interstitial Lung Disease. Chest 1998, 113: 1148. PMID: 9554672, DOI: 10.1378/chest.113.4.1148.
- Hansen J, Casaburi R. Patterns of Dissimilarities Among Instrument Models in Measuring Po2, Pco2, and pH in Blood Gas Laboratories. Chest 1998, 113: 780-787. PMID: 9515857, DOI: 10.1378/chest.113.3.780.
- Stringer W, Hansen J, Wasserman K. Cardiac output estimated noninvasively from oxygen uptake during exercise. Journal Of Applied Physiology 1997, 82: 908-912. PMID: 9074981, DOI: 10.1152/jappl.1997.82.3.908.
- Hansen J, Wasserman K. Pathophysiology of Activity Limitation in Patients With Interstitial Lung Disease. Chest 1996, 109: 1566-1576. PMID: 8769513, DOI: 10.1378/chest.109.6.1566.
- A Statistical Approach for Assessment of Bronchodilator Responsiveness in Pulmonary Function TestingHansen J, Casaburi R, Goldberg A. A Statistical Approach for Assessment of Bronchodilator Responsiveness in Pulmonary Function Testing. Chest 1993, 104: 1119-1126. PMID: 8404178, DOI: 10.1378/chest.104.4.1119.
- Hansen J. Participant Responses to Blood Gas Proficiency Testing Reports. Chest 1992, 101: 1240-1244. PMID: 1582278, DOI: 10.1378/chest.101.5.1240.
- Hansen J, Casaburi R, Crapo R, Jensen R. Assessing Precision and Accuracy in Blood Gas Proficiency Testing: Reply. American Journal Of Respiratory And Critical Care Medicine 1992, 145: 498-498. DOI: 10.1164/ajrccm/145.2_pt_1.498-a.
- Hansen J, Casaburi R, Crapo R, Jensen R. Assessing Precision and Accuracy in Blood Gas Proficiency Testing. American Journal Of Respiratory And Critical Care Medicine 1990, 141: 1190-1193. PMID: 2111104, DOI: 10.1164/ajrccm/141.5_pt_1.1190.
- Hansen J. Diet and flight hypoxemia. Annals Of Internal Medicine 1989, 111: 859-60. PMID: 2817638, DOI: 10.7326/0003-4819-111-10-859_2.
- Casaburi R, Daly J, Hansen J, Effros R. Abrupt changes in mixed venous blood gas composition after the onset of exercise. Journal Of Applied Physiology 1989, 67: 1106-1112. PMID: 2507504, DOI: 10.1152/jappl.1989.67.3.1106.
- Hansen J, Jensen R, Casaburi R, Crapo R. Comparison of Blood Gas Analyzer Biases in Measuring Tonometered Blood and a Fluorocarbon-containing, Proficiency-testing Material. American Journal Of Respiratory And Critical Care Medicine 1989, 140: 403-409. PMID: 2504088, DOI: 10.1164/ajrccm/140.2.403.
- Hansen J. Arterial Blood Gases. Clinics In Chest Medicine 1989, 10: 227-237. PMID: 2661120, DOI: 10.1016/s0272-5231(21)00624-9.
- Hansen J, Feil M. Blood Gas Quality Control Materials Compered to Tonometered Blood in Examining for Interinstrument Bias in Po2. Chest 1988, 94: 49-54. PMID: 3383656, DOI: 10.1378/chest.94.1.49.
- ROBINSON T, SUE D, HUSZCZUK A, WEILER-RAVELL D, HANSEN J. Infra-arterial arid cuff blood pressure responses during incremental cycle ergometry. Medicine & Science In Sports & Exercise 1988, 20: 142. DOI: 10.1249/00005768-198804001-00007.
- Hansen J, Casaburi R, Cooper D, Wasserman K. Oxygen uptake as related to work rate increment during cycle ergometer exercise. European Journal Of Applied Physiology 1988, 57: 140-145. PMID: 3349978, DOI: 10.1007/bf00640653.
- Baber S, Laks M, Hansen J, Selvester R. Effects of pulmonary emphysema on QRS infarct size score. Journal Of Electrocardiology 1988, 21: s112-s116. PMID: 3216165, DOI: 10.1016/0022-0736(88)90070-2.
- Robinson T, Sue D, Huszczuk A, Weiler-Ravell D, Hansen J. Intra-arterial and cuff blood pressure responses during incremental cycle ergometry. Medicine & Science In Sports & Exercise 1988, 20: 142-9. PMID: 3367749, DOI: 10.1249/00005768-198820020-00007.
- Sue D, Oren A, Hansen J, Wasserman K. Diffusing Capacity for Carbon Monoxide as a Predictor of Gas Exchange during Exercise. The New England Journal Of Medicine 1987, 316: 1301-1306. PMID: 3574401, DOI: 10.1056/nejm198705213162103.
- Wasserman K, Hansen J, Sue D, Whipp B, Froelicher V. Principles of Exercise Testing and Interpretation. Journal Of Cardiopulmonary Rehabilitation And Prevention 1987, 7: 189. DOI: 10.1097/00008483-198704000-00014.
- Hansen J, Sue D, Oren A, Wasserman K. Relation of oxygen uptake to work rate in normal men and men with circulatory disorders. The American Journal Of Cardiology 1987, 59: 669-674. PMID: 3825911, DOI: 10.1016/0002-9149(87)91190-8.
- Hansen J, Casaburi R. Validity of Ear Oximetry in Clinical Exercise Testing. Chest 1987, 91: 333-337. PMID: 3816311, DOI: 10.1378/chest.91.3.333.
- Oren A, Sue D, Hansen J, Torrance D, Wasserman K. The Role of Exercise Testing in Impairment Evaluation. American Journal Of Respiratory And Critical Care Medicine 1987, 135: 230-235. PMID: 3800148, DOI: 10.1164/arrd.1987.135.1.230.
- Ben-Dov I, Sue D, Hansen J, Wasserman K. Bronchodilatation and Attenuation of Exercise-Induced Bronchospasm by PY 108−068, a New Calcium Antagonist. American Journal Of Respiratory And Critical Care Medicine 1986, 133: 116-119. PMID: 3942368, DOI: 10.1164/arrd.1986.133.1.116.
- Olive S, Hansen J, Sue D, Ben-Dov I, Wasserman K. Comparison of PY 108-068, a New Calcium Antagonist, with Nifedipine in Exercise-Induced Asthma. Chest 1986, 90: 208-211. PMID: 3525023, DOI: 10.1378/chest.90.2.208.
- Hansen J, Clausen J, Levy S, Mohler J, Van Kessel A. Proficiency Testing Materials for pH and Blood Gases The California Thoracic Society Experience. Chest 1986, 89: 214-217. PMID: 3943381, DOI: 10.1378/chest.89.2.214.
- Sue D, Oren A, Hansen J, Wasserman K. Lung Function and Exercise Performance in Smoking and Nonsmoking Asbestos-exposed Workers. American Journal Of Respiratory And Critical Care Medicine 1985, 132: 612-618. PMID: 4037534, DOI: 10.1164/arrd.1985.132.3.612.
- Hirsch G, Sue D, Wasserman K, Robinson T, Hansen J. Immediate effects of cigarette smoking on cardiorespiratory responses to exercise. Journal Of Applied Physiology 1985, 58: 1975-1981. PMID: 4008417, DOI: 10.1152/jappl.1985.58.6.1975.
- Hansen J. Alcohol Consumption and Emphysema. Chest 1984, 86: 804. PMID: 6488933, DOI: 10.1378/chest.86.5.804-a.
- Sue D, Hansen J. Normal Values in Adults During Exercise Testing. Clinics In Chest Medicine 1984, 5: 89-98. PMID: 6723246, DOI: 10.1016/s0272-5231(21)00234-3.
- Hansen J, Sue D, Wasserman K. Predicted Values for Clinical Exercise Testing. American Journal Of Respiratory And Critical Care Medicine 1984, 129: s49-s55. PMID: 6421218, DOI: 10.1164/arrd.1984.129.2p2.s49.
- Buchfuhrer M, Hansen J, Robinson T, Sue D, Wasserman K, Whipp B. Optimizing the exercise protocol for cardiopulmonary assessment. Journal Of Applied Physiology 1983, 55: 1558-1564. PMID: 6643191, DOI: 10.1152/jappl.1983.55.5.1558.
- Ray C, Sue D, Bray G, Hansen J, Wasserman K. Effects of Obesity on Respiratory Function. American Journal Of Respiratory And Critical Care Medicine 1983, 128: 501-506. PMID: 6614644, DOI: 10.1164/arrd.1983.128.3.501.
- Sue D, Van Meter L, Hansen J, Wasserman K. Exercise gas exchange in asthmatics after beta-adrenergic blockade. Journal Of Applied Physiology 1983, 55: 529-533. PMID: 6137468, DOI: 10.1152/jappl.1983.55.2.529.
- Nery L, Wasserman K, Andrews J, Huntsman D, Hansen J, Whipp B. Ventilatory and gas exchange kinetics during exercise in chronic airways obstruction. Journal Of Applied Physiology 1982, 53: 1594-1602. PMID: 6818216, DOI: 10.1152/jappl.1982.53.6.1594.
- Furuike A, Sue D, Hansen J, Wasserman K. Comparison of Physiologic Dead Space/Tidal Volume Ratio and Alveolar-Arterial PO2 Difference During Incremental and Constant Work Exercise. American Journal Of Respiratory And Critical Care Medicine 1982, 126: 579-583. PMID: 7125348, DOI: 10.1164/arrd.1982.126.3.579.
- Sue D, Hansen J, Wasserman K. The value of exercise in testing beta blockade and airway reactivity in asthmatic patients. American Heart Journal 1982, 104: 442-445. PMID: 7102529, DOI: 10.1016/0002-8703(82)90137-5.
- Hansen J, Stone M, Ong S, Van Kessel A. Evaluation of Blood Gas Quality Control and Proficiency Testing Materials by Tonometry. American Journal Of Respiratory And Critical Care Medicine 1982, 125: 480-483. PMID: 7073119, DOI: 10.1164/arrd.1982.125.4.480.
- Sue D, Hansen J, Wasserman K. Beta-Adrenergic Blockade with Pindolol (LB-46) in Mild to Moderate Asthma. Chest 1981, 80: 537-542. PMID: 7297143, DOI: 10.1378/chest.80.5.537.
- Sue D, Hansen J, Blais M, Wasserman K. Measurement and analysis of gas exchange during exercise using a programmable calculator. Journal Of Applied Physiology 1980, 49: 456-461. PMID: 6782049, DOI: 10.1152/jappl.1980.49.3.456.
- Hansen J, Sue D. Should Blood Gas Measurements Be Corrected for the Patient's Temperature? The New England Journal Of Medicine 1980, 303: 341. PMID: 7383135, DOI: 10.1056/nejm198008073030616.
- Schiffman P, Ryan A, Whipp B, Hansen J, Wasserman K. Hyperoxic attenuation of exercise-induced bronchospasm in asthmatics. Journal Of Clinical Investigation 1979, 63: 30-37. PMID: 762245, PMCID: PMC371914, DOI: 10.1172/jci109274.
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