Classical Hematology
Smilow Cancer Hospital Care Center - Spring Brook Common
240 Indian River Road
Orange, CT 06477
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477
Alfred Lee, MD, PhD
Hematology, Hematology & Oncology
Telehealth is available
Patient type treated
Adult
Accepting new patients
Yes
Referral required
From patients or physicians
Biography
Alfred Ian Lee, MD, PhD, is Professor of Medicine (Hematology) and Program Director for the hematology/oncology fellowship program. He received his MD/PhD from the Yale School of Medicine in 2004. Dr. Lee completed residency in internal medicine at Brigham & Women’s Hospital, where he served as Chief Medical Resident, followed by a fellowship in hematology/oncology at Dana-Farber Cancer Institute. His primary academic interests are classical hematology, thrombosis, and medical education.
He has received such honors as the Charles W. Bohmfalk Prize for teaching in the basic sciences, the Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education, the Yale Cancer Center Award for Mentorship Excellence, and the David J. Lefell Prize for Clinical Excellence.
Titles
- Professor of Medicine (Hematology)
- Chief, Classical Hematology Program
Education & Training
- FellowshipDana Farber Cancer Institute (2011)
- Chief Medical ResidentBrigham & Women's Hospital (2010)
- ResidencyBrigham & Women's Hospital (2007)
- MDYale School of Medicine (2004)
- PhDYale University (2003)
Additional Information
Honors & Recognitions
- Yale Cancer Center Award for Mentorship Excellence: Yale Cancer Center (2022)
- David J. Lefell Prize for clinical excellence: Yale Medicine (2020)
- Fred Kantor Teacher of the Year Award: Yale Internal Medicine Traditional Residency Program (2018)
- Inspiring Yale Award: Yale University Graduate & Professional Student Senate (2018)
- Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education: Yale School of Medicine (2017)
- Connecticut Top Doc: Connecticut Magazine (2017), (2019), (2020), (2021)
- Charles W. Bohmfalk Prize for teaching in the basic sciences: Yale School of Medicine (2016)
- David S. Fischer Annual Award for outstanding teaching and mentoring of fellows in Hematology: Yale Cancer Center (2012), (2015), (2019)
- Faculty Teacher of the Year Award: Yale Internal Medicine Traditional Residency Program (2012)
Professional Service
- Guideline Panel on the Use of Anticoagulation in Patients with COVID-19, American Society of Hematology (2020 - Present): Member
- NIH ClinGen Hemostasis/Thrombosis Variant Curation Expert Panel (2020 - Present): Member
- Medical Educators Institute, American Society of Hematology (2019 - Present): Faculty Member
- NIH ClinGen Hemostasis/Thrombosis Expert Panel (2019 - Present): Member
- Recruitment & Retention Working Group, American Society of Hematology (2017 - Present): Chair
- Committee on Training, American Society of Hematology (2015 - Present): Member
- National Comprehensive Cancer Network Cancer-Associated Venous Thromboembolic Disease Panel (2015 - Present): Member
Publications
- Kewan T, Lee A, Van Doren L. Prospective Evaluation of Large Language Model Integration Into a Classical Hematology Case Conference. JMIR Formative Research 2026, 10: e89939. PMID: 41849561, PMCID: PMC12998601, DOI: 10.2196/89939.
- Allen C, Streiff M, Naik R, Seam N, Kadri S, Lee A, Knauert M, Goshua G. Utilization patterns of hematology consultation in the intensive care unit: an 11-year single-center experience. Blood Advances 2026, 10: 1943-1946. PMID: 41348859, PMCID: PMC12995476, DOI: 10.1182/bloodadvances.2025018327.
- Goshua G, Lee A. Thrombopoietin-Receptor Agonists in Chemotherapy-Induced Thrombocytopenia. The New England Journal Of Medicine 2026, 394: 1125-1126. PMID: 41812200, DOI: 10.1056/nejme2517578.
- Restrepo V, Marshall A, Feder K, Afranie-Sakyi J, Carrithers B, Jones-Wonni B, Mensah C, Zhou B, Mistry R, McGann P, Azar S, De Castro L, Calhoun C, Bozang K, Brown T, Lee A, Van Doren L. Burnout in Sickle Cell Disease-Focused Hematology-Oncology Trained Physicians: A National Cross-Sectional Study. Blood Advances 2026 PMID: 41817318, DOI: 10.1182/bloodadvances.2025018338.
- Wang D, Sra M, Ito S, Ng D, Glaeser-Khan S, Wang D, Hirniak S, Lee A, Cuker A, Goshua G. Cost-effectiveness of first-line IV vs oral iron for iron-deficiency anemia in women with heavy menstrual bleeding. Blood Advances 2026, 10: 1508-1517. PMID: 41504430, PMCID: PMC12952766, DOI: 10.1182/bloodadvances.2025018315.
- Ryu J, Lee A. When genotype and phenotype disagree: rethinking thrombophilia testing in the genomic era. Journal Of Thrombosis And Haemostasis 2025, 23: 3806-3808. PMID: 41260738, DOI: 10.1016/j.jtha.2025.07.044.
- Ryu J, Lee A. Molecular clues to venous thromboembolism recurrence. Blood 2025, 146: 2281-2282. PMID: 41196621, DOI: 10.1182/blood.2025030460.
- Pine A, Butt A, Andreoli L, Knight J, Gerosa M, Cecchi I, Branch D, Lopez-Pedrera R, Belmont H, Kello N, Petri M, Cervera R, Pengo V, Meroni P, Cohen H, Willis R, Bertolccini M, Goshua G, Gu S, Hwa J, Lee A, Erkan D, Sharda A. A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry. Frontiers In Immunology 2025, 16: 1676578. PMID: 41181143, PMCID: PMC12571811, DOI: 10.3389/fimmu.2025.1676578.
- Butt A, Sharda A, Lee A, Knight J. Analytical Review: Neutrophil Extracellular Traps and Antiphospholipid syndrome. Transfusion Medicine Reviews 2025, 40: 150909. PMID: 40783311, DOI: 10.1016/j.tmrv.2025.150909.
- Stempel J, Wang R, Lee A, Zeidan A, Ma X, Podoltsev N. Calcineurin inhibitor and eltrombopag combination for acquired aplastic anemia: results from a large national database. Therapeutic Advances In Hematology 2025, 16: 20406207251394775. PMID: 41333634, PMCID: PMC12665816, DOI: 10.1177/20406207251394775.
- Roy A, Bakouny Z, Dizman N, Paul M, Ozay Z, Lal B, Nawfal R, Eid M, Chehade R, Machaalani M, Butt A, Aggarwal C, Bekaii-Saab T, Chavez-MacGregor M, Lopes G, Marshall A, Murphy M, Owonikoko T, Xie W, Lee A, Choueiri T. International Medical Graduates Representation at International Oncology Conference Meetings: An Analysis of ASCO Annual Meetings. JCO Oncology Practice 2025, 22: 708-716. PMID: 40577682, DOI: 10.1200/op-25-00067.
- Hundito A, Wells N, Tuttle M, Alameddine D, Huttler J, Slade M, Strosberg D, Lee A, Guzman R, Ochoa Chaar C. The incidence and significance of delayed bleeding events after lower extremity revascularization in patients with advanced peripheral arterial disease. Journal Of Vascular Surgery 2025, 82: 969-977.e5. PMID: 40187383, DOI: 10.1016/j.jvs.2025.03.394.
- Siegal D, Tseng E, Schünemann H, Angchaisuksiri P, Cuker A, Dane K, DeSancho M, Diuguid D, Griffin D, Klok F, Lee A, Neumann I, Pai A, Righini M, Sanfilippo K, Terrell D, Akl E, Al Jabiri R, Al Jabiri Y, Barbara A, Bognanni A, Akl I, Boulos M, Brignardello-Petersen R, Chan M, Charide R, Colunga-Lozano L, Dearness K, Darzi A, Hussein H, Karam S, Kolb P, Mansour R, Morgano G, Morsi R, Muti-Schünemann G, Nadim M, Noori A, Philip B, Piggott T, Qiu Y, Benitez Y, Schünemann F, Stevens A, Solo K, Wiercioch W, Mustafa R, Nieuwlaat R. American Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary. Blood Advances 2025, 9: 1247-1260. PMID: 39437797, PMCID: PMC11950770, DOI: 10.1182/bloodadvances.2024014219.
- Stempel J, Wang R, Lee A, Zeidan A, Ma X, Podoltsev N. Initial management of patients with acquired aplastic anemia in the United States: results from a large national claims database. Annals Of Hematology 2025, 104: 2507-2515. PMID: 40102305, PMCID: PMC12052795, DOI: 10.1007/s00277-025-06307-z.
- Chaar C, Chan S, Lee A, Bikdeli B, Tiberio G, Chopard R, Weinberg I, Yamashita Y, Nikandish R, Monreal M. Intercontinental variations in the presentation and management of venous thromboembolism. JVS-Vascular Insights 2025, 3: 100201. DOI: 10.1016/j.jvsvi.2025.100201.
- Ali S, Chan S, Brahmandam A, Xu Y, Deng Y, Elbadawy A, Lee A, Ochoa Chaar C. The Incidence and Significance of Iliac Vein Stenosis in Patients with Deep Vein Thrombosis. Annals Of Vascular Surgery 2024, 111: 310-318. PMID: 39617297, DOI: 10.1016/j.avsg.2024.11.016.
- Restrepo-Espinosa V, Lee A, Prozora S, Patel P, Nassiri N. In-human clinical experience with direct stick embolization of low-flow vascular malformations using a mammalian target of rapamycin inhibitor. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2024, 13: 101997. PMID: 39515753, PMCID: PMC12014304, DOI: 10.1016/j.jvsv.2024.101997.
- Ito S, Chetlapalli K, Wang D, Potnis K, Richmond R, Krumholz H, Lee A, Cuker A, Goshua G. Cost-effectiveness of iptacopan for paroxysmal nocturnal hemoglobinuria. Blood 2024, 145: 127-140. PMID: 39374533, PMCID: PMC11738035, DOI: 10.1182/blood.2024025176.
- Dizman N, Bakouny Z, Haykal T, Riano I, Desai A, Butt A, Basu A, Zhao D, Saad E, Saliby R, Gosain R, Gosain R, Ardeshir F, Deng L, Matt-Amaral L, Arnaoutakis K, Bekaii-Saab T, Manochakian R, Marshall A, Forde P, Murphy M, Subbiah V, Chavez-MacGregor M, Owonikoko T, Lopes G, Aggarwal C, Lee A, Choueiri T. Guide to Understanding and Supporting International Medical Graduates in Hematology/Oncology by the ASCO International Medical Graduates Community of Practice. JCO Oncology Practice 2024, 21: 292-299. PMID: 39374449, PMCID: PMC12455576, DOI: 10.1200/op-24-00565.
- Qureshy Z, Nair P, Vesely S, King A, Lee A, Connell N, von Drygalski A, Wong-Sefidan I, Murphy M, Mistry R, Zon R, Reid E, Fritz J, Park S. Evaluating the impact of a year-long external mentorship pilot program in classical hematology. Blood Advances 2024, 8: 4833-4844. PMID: 39087874, PMCID: PMC11416643, DOI: 10.1182/bloodadvances.2024013218.
- Gu S, Butt A, Schulz V, Rinder H, Lee A, Gallagher P, Hwa J, Bona R. Phenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies. Blood Cells Molecules And Diseases 2024, 110: 102893. PMID: 39260211, DOI: 10.1016/j.bcmd.2024.102893.
- Allen C, Heskel M, Butt A, Tormey C, Pine A, Lee A, Gautam S. Factor VIII Levels and ISTH Disseminated Intravascular Coagulation Scores Do Not Distinguish Disseminated Intravascular Coagulation from the Coagulopathy of Liver Disease. Acta Haematologica 2024, 148: 220-225. PMID: 39004080, PMCID: PMC12106121, DOI: 10.1159/000540239.
- Prince E, Feder K, Calhoun C, Lee A, Carroll C, Restrepo V, Van Doren L. Trainees’ perspectives on sickle cell education: a qualitative needs assessment. BMC Medical Education 2024, 24: 715. PMID: 38956512, PMCID: PMC11220977, DOI: 10.1186/s12909-024-05696-5.
- Ito S, Wang D, Purcell A, Chetlapalli K, Lee A, Cuker A, Goshua G. Cost‐effectiveness of sutimlimab in cold agglutinin disease. American Journal Of Hematology 2024, 99: 1475-1484. PMID: 38733355, DOI: 10.1002/ajh.27358.
- Butt A, Christian J, Kress A, Lu B, Hurwitz M, Goldberg S, Podoltsev N, Gilkes L, Lee A. Providing 0.1 Full-Time Equivalent (FTE) Support to Fellowship Core Faculty Improves Faculty Involvement in Fellowship Education and Recruitment. Journal Of Cancer Education 2024, 39: 325-334. PMID: 38430454, PMCID: PMC12279297, DOI: 10.1007/s13187-024-02414-z.
- Rodriguez P, Brahmandam A, Turner J, Lee A, Chaar C. Endovascular treatment of renal vein thrombosis in a young patient with lung transplant. Journal Of Vascular Surgery Cases And Innovative Techniques 2024, 10: 101437. PMID: 38464891, PMCID: PMC10924198, DOI: 10.1016/j.jvscit.2024.101437.
- Chase M, Drews R, Zumberg M, Ellis L, Reid E, Gerds A, Lee A, Hobbs G, Berry J, Freed J. Consensus Recommendations on Peripheral Blood Smear Review: Defining Curricular Standards and Fellow Competency. Blood Advances 2023, 7: 3244-3252. PMID: 36930800, PMCID: PMC10336252, DOI: 10.1182/bloodadvances.2023009843.
- Lee A, Masselink LE, De Castro LM, Marshall AL, Connell NT, Dent GA, Fritz J, Homer M, Lucas TL, Naik RP, Nelson M, O'Connell C, Rajasekhar A, Reynolds R, Sharma D, Smith M, Weeks LD, Erikson CE. Burnout in U.S. hematologists and oncologists: impact of compensation models and advanced practice provider support. Blood Advances 2023, 7: 3058-3068. PMID: 35476017, PMCID: PMC10331414, DOI: 10.1182/bloodadvances.2021006140.
- Al-Samkari H, Panch S, Lee A. Please Do Call Us Classical Hematologists. The Hematologist 2023, 20 DOI: 10.1182/hem.v20.4.202347.
- Allen C, Gautam S, Cheng W, Pine A, Podoltsev N, Zeidan A, Lee A, Shallis R. Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome. Acta Haematologica 2023, 146: 287-292. PMID: 37166332, PMCID: PMC12106122, DOI: 10.1159/000530153.
- Goshua G, Lee A. Summiting thrombotic hazards in glioma. Blood 2023, 141: 1245-1246. PMID: 36929442, DOI: 10.1182/blood.2022019020.
- Goshua G, Bendapudi P, Lee A. Thrombosis questions from the inpatient wards. Hematology 2022, 2022: 481-490. PMID: 36485139, PMCID: PMC9819989, DOI: 10.1182/hematology.2022000384.
- Butt A, Mankbadi M, Erikson C, Marshall A, Masselink LE, Tong G, Hafler J, Podoltsev N, Lee AI. Bias Against International Medical Graduates in the Hematology/Oncology Fellowship Recruitment Process: Findings From a Nationwide Survey of Fellowship Program Directors. JCO Oncology Practice 2022, 18: 783-787. PMID: 36108253, DOI: 10.1200/op.22.00219.
- Butt A, Erkan D, Lee A. COVID-19 and antiphospholipid antibodies. Best Practice & Research Clinical Haematology 2022, 35: 101402. PMID: 36494152, PMCID: PMC9568270, DOI: 10.1016/j.beha.2022.101402.
- Stempel JM, Podoltsev NA, Zeidan AM, Lee AI, Shallis RM. Concealed by the convenient: acquired von Willebrand syndrome in myeloproliferative neoplasm requires a thorough evaluation. Annals Of Hematology 2022, 101: 2559-2561. PMID: 35984499, DOI: 10.1007/s00277-022-04943-3.
- Butt A, Muradashvili T, Soliman S, Li F, Burns AJ, Brooks A, Browning S, Bar N, Borgman G, Goshua G, Hwa J, Martin K, Rinder H, Tormey C, Pine AB, Bona RD, Lee AI, Neparidze N. Association of iron infusion reactions with ABO blood type. European Journal Of Haematology 2022, 109: 519-525. PMID: 35871468, DOI: 10.1111/ejh.13838.
- Al-Samkari H, Loren AW, Lee AI. The case for classical haematology: the impact of a name and the future of a field. The Lancet Haematology 2022, 9: e455-e459. PMID: 35500590, DOI: 10.1016/s2352-3026(22)00096-5.
- Tyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.
- Lee EJ, Lee AI. Cerebral venous sinus thrombosis after vaccination: the UK experience. The Lancet 2021, 398: 1107-1109. PMID: 34370974, PMCID: PMC8346246, DOI: 10.1016/s0140-6736(21)01788-8.
- Pischel L, Geirsson A, Magaldi J, Martinello RA, Lee AI. A Brewing Back Pain. The New England Journal Of Medicine 2021, 385: 66-72. PMID: 34192434, PMCID: PMC9273048, DOI: 10.1056/nejmcps2034802.
- McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee A, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. Journal Of Hepatology 2021, 75: 647-658. PMID: 33991637, PMCID: PMC8285256, DOI: 10.1016/j.jhep.2021.04.050.
- Ma L, Sahu S, Cano M, Kuppuswamy V, Bajwa J, McPhatter J, Pine A, Meizlish M, Goshua G, Chang C, Zhang H, Price C, Bahel P, Rinder H, Lei T, Day A, Reynolds D, Wu X, Schriefer R, Rauseo A, Goss C, O’Halloran J, Presti R, Kim A, Gelman A, Dela Cruz C, Lee A, Mudd P, Chun H, Atkinson J, Kulkarni H. Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection. Science Immunology 2021, 6: eabh2259. PMID: 34446527, PMCID: PMC8158979, DOI: 10.1126/sciimmunol.abh2259.
- Goshua G, Sinha P, Hendrickson J, Tormey C, Bendapudi PK, Lee AI. Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura. Blood 2020, 137: 969-976. PMID: 33280030, PMCID: PMC7918179, DOI: 10.1182/blood.2020006052.
- Odio CD, O'Brien CR, Jacox J, Jain D, Lee AI. Cryptic Cachexia. The New England Journal Of Medicine 2020, 383: 68-74. PMID: 32609985, DOI: 10.1056/nejmcps1817531.
- Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/s2352-3026(20)30216-7.
- Schwartz AR, Siegel MD, Lee AI. A novel approach to the program evaluation committee. BMC Medical Education 2019, 19: 465. PMID: 31842868, PMCID: PMC6916454, DOI: 10.1186/s12909-019-1899-x.
- Lee AI, Connors JM. The next(gen) step in coagulation testing. Blood 2019, 134: 2002-2003. PMID: 31805193, DOI: 10.1182/blood.2019001414.
- Sharma D, Wallace N, Levinsohn EA, Marshall AL, Kayoumi K, Madero J, Homer M, Reynolds R, Hafler J, Podoltsev NA, Lee AI. Trends and factors affecting the US adult hematology workforce: a mixed methods study. Blood Advances 2019, 3: 3550-3561. PMID: 31738829, PMCID: PMC6880914, DOI: 10.1182/bloodadvances.2019000307.
- Masselink LE, Erikson CE, Connell NT, De Castro LM, Dent GA, Marshall AL, Naik RP, Nelson M, O’Connell C, Rajasekhar A, Sharma D, Smith M, Lee AI. Associations between hematology/oncology fellows’ training and mentorship experiences and hematology-only career plans. Blood Advances 2019, 3: 3278-3286. PMID: 31698456, PMCID: PMC6855099, DOI: 10.1182/bloodadvances.2019000569.
- Djulbegovic M, Dugdale LS, Lee AI. Evaluation of Polycythemia: A Teachable Moment. JAMA Internal Medicine 2018, 178: 128-130. PMID: 29131894, DOI: 10.1001/jamainternmed.2017.6213.
- Lee A, Lee E. Anticoagulation for Proximal Deep Vein Thrombosis. 2017, 299-313. DOI: 10.1007/978-3-319-65226-9_23.
- Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI. Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances 2017, 1: 1224-1237. PMID: 29296762, PMCID: PMC5728544, DOI: 10.1182/bloodadvances.2017005249.
- Lee A, Tormey C. The Hidden Lesion. The New England Journal Of Medicine 2016, 375: 1199. PMID: 27653584, DOI: 10.1056/nejmc1608553.
- Lee AI, Chaar C. The Hidden Lesion. The New England Journal Of Medicine 2016, 374: 2160-2165. PMID: 27248622, DOI: 10.1056/nejmcps1406615.
- Varughese N, Duong A, Emre S, Xu M, Lee AI. Venting the Spleen. The New England Journal Of Medicine 2013, 369: 1357-1363. PMID: 24088096, DOI: 10.1056/nejmcps1210943.
- Lee AI, Koo S, Vaidya A, Katz JT, Loscalzo J. A Bird's-Eye View of Fever. The New England Journal Of Medicine 2011, 365: 1727-1732. PMID: 22047564, DOI: 10.1056/nejmcps1012518.
- Fugmann S, Lee A, Shockett P, Villey I, Schatz D. The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition. Annual Review Of Immunology 2000, 18: 495-527. PMID: 10837067, DOI: 10.1146/annurev.immunol.18.1.495.
Locations
Classical Hematology
Smilow Cancer Hospital Care Center - Spring Brook Common
240 Indian River Road
Orange, CT 06477
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477
Biography
Alfred Ian Lee, MD, PhD, is Professor of Medicine (Hematology) and Program Director for the hematology/oncology fellowship program. He received his MD/PhD from the Yale School of Medicine in 2004. Dr. Lee completed residency in internal medicine at Brigham & Women’s Hospital, where he served as Chief Medical Resident, followed by a fellowship in hematology/oncology at Dana-Farber Cancer Institute. His primary academic interests are classical hematology, thrombosis, and medical education.
He has received such honors as the Charles W. Bohmfalk Prize for teaching in the basic sciences, the Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education, the Yale Cancer Center Award for Mentorship Excellence, and the David J. Lefell Prize for Clinical Excellence.
Titles
- Professor of Medicine (Hematology)
- Chief, Classical Hematology Program
Education & Training
- FellowshipDana Farber Cancer Institute (2011)
- Chief Medical ResidentBrigham & Women's Hospital (2010)
- ResidencyBrigham & Women's Hospital (2007)
- MDYale School of Medicine (2004)
- PhDYale University (2003)
Additional Information
Honors & Recognitions
- Yale Cancer Center Award for Mentorship Excellence: Yale Cancer Center (2022)
- David J. Lefell Prize for clinical excellence: Yale Medicine (2020)
- Fred Kantor Teacher of the Year Award: Yale Internal Medicine Traditional Residency Program (2018)
- Inspiring Yale Award: Yale University Graduate & Professional Student Senate (2018)
- Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education: Yale School of Medicine (2017)
- Connecticut Top Doc: Connecticut Magazine (2017), (2019), (2020), (2021)
- Charles W. Bohmfalk Prize for teaching in the basic sciences: Yale School of Medicine (2016)
- David S. Fischer Annual Award for outstanding teaching and mentoring of fellows in Hematology: Yale Cancer Center (2012), (2015), (2019)
- Faculty Teacher of the Year Award: Yale Internal Medicine Traditional Residency Program (2012)
Professional Service
- Guideline Panel on the Use of Anticoagulation in Patients with COVID-19, American Society of Hematology (2020 - Present): Member
- NIH ClinGen Hemostasis/Thrombosis Variant Curation Expert Panel (2020 - Present): Member
- Medical Educators Institute, American Society of Hematology (2019 - Present): Faculty Member
- NIH ClinGen Hemostasis/Thrombosis Expert Panel (2019 - Present): Member
- Recruitment & Retention Working Group, American Society of Hematology (2017 - Present): Chair
- Committee on Training, American Society of Hematology (2015 - Present): Member
- National Comprehensive Cancer Network Cancer-Associated Venous Thromboembolic Disease Panel (2015 - Present): Member
Publications
- Kewan T, Lee A, Van Doren L. Prospective Evaluation of Large Language Model Integration Into a Classical Hematology Case Conference. JMIR Formative Research 2026, 10: e89939. PMID: 41849561, PMCID: PMC12998601, DOI: 10.2196/89939.
- Allen C, Streiff M, Naik R, Seam N, Kadri S, Lee A, Knauert M, Goshua G. Utilization patterns of hematology consultation in the intensive care unit: an 11-year single-center experience. Blood Advances 2026, 10: 1943-1946. PMID: 41348859, PMCID: PMC12995476, DOI: 10.1182/bloodadvances.2025018327.
- Goshua G, Lee A. Thrombopoietin-Receptor Agonists in Chemotherapy-Induced Thrombocytopenia. The New England Journal Of Medicine 2026, 394: 1125-1126. PMID: 41812200, DOI: 10.1056/nejme2517578.
- Restrepo V, Marshall A, Feder K, Afranie-Sakyi J, Carrithers B, Jones-Wonni B, Mensah C, Zhou B, Mistry R, McGann P, Azar S, De Castro L, Calhoun C, Bozang K, Brown T, Lee A, Van Doren L. Burnout in Sickle Cell Disease-Focused Hematology-Oncology Trained Physicians: A National Cross-Sectional Study. Blood Advances 2026 PMID: 41817318, DOI: 10.1182/bloodadvances.2025018338.
- Wang D, Sra M, Ito S, Ng D, Glaeser-Khan S, Wang D, Hirniak S, Lee A, Cuker A, Goshua G. Cost-effectiveness of first-line IV vs oral iron for iron-deficiency anemia in women with heavy menstrual bleeding. Blood Advances 2026, 10: 1508-1517. PMID: 41504430, PMCID: PMC12952766, DOI: 10.1182/bloodadvances.2025018315.
- Ryu J, Lee A. When genotype and phenotype disagree: rethinking thrombophilia testing in the genomic era. Journal Of Thrombosis And Haemostasis 2025, 23: 3806-3808. PMID: 41260738, DOI: 10.1016/j.jtha.2025.07.044.
- Ryu J, Lee A. Molecular clues to venous thromboembolism recurrence. Blood 2025, 146: 2281-2282. PMID: 41196621, DOI: 10.1182/blood.2025030460.
- Pine A, Butt A, Andreoli L, Knight J, Gerosa M, Cecchi I, Branch D, Lopez-Pedrera R, Belmont H, Kello N, Petri M, Cervera R, Pengo V, Meroni P, Cohen H, Willis R, Bertolccini M, Goshua G, Gu S, Hwa J, Lee A, Erkan D, Sharda A. A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry. Frontiers In Immunology 2025, 16: 1676578. PMID: 41181143, PMCID: PMC12571811, DOI: 10.3389/fimmu.2025.1676578.
- Butt A, Sharda A, Lee A, Knight J. Analytical Review: Neutrophil Extracellular Traps and Antiphospholipid syndrome. Transfusion Medicine Reviews 2025, 40: 150909. PMID: 40783311, DOI: 10.1016/j.tmrv.2025.150909.
- Stempel J, Wang R, Lee A, Zeidan A, Ma X, Podoltsev N. Calcineurin inhibitor and eltrombopag combination for acquired aplastic anemia: results from a large national database. Therapeutic Advances In Hematology 2025, 16: 20406207251394775. PMID: 41333634, PMCID: PMC12665816, DOI: 10.1177/20406207251394775.
- Roy A, Bakouny Z, Dizman N, Paul M, Ozay Z, Lal B, Nawfal R, Eid M, Chehade R, Machaalani M, Butt A, Aggarwal C, Bekaii-Saab T, Chavez-MacGregor M, Lopes G, Marshall A, Murphy M, Owonikoko T, Xie W, Lee A, Choueiri T. International Medical Graduates Representation at International Oncology Conference Meetings: An Analysis of ASCO Annual Meetings. JCO Oncology Practice 2025, 22: 708-716. PMID: 40577682, DOI: 10.1200/op-25-00067.
- Hundito A, Wells N, Tuttle M, Alameddine D, Huttler J, Slade M, Strosberg D, Lee A, Guzman R, Ochoa Chaar C. The incidence and significance of delayed bleeding events after lower extremity revascularization in patients with advanced peripheral arterial disease. Journal Of Vascular Surgery 2025, 82: 969-977.e5. PMID: 40187383, DOI: 10.1016/j.jvs.2025.03.394.
- Siegal D, Tseng E, Schünemann H, Angchaisuksiri P, Cuker A, Dane K, DeSancho M, Diuguid D, Griffin D, Klok F, Lee A, Neumann I, Pai A, Righini M, Sanfilippo K, Terrell D, Akl E, Al Jabiri R, Al Jabiri Y, Barbara A, Bognanni A, Akl I, Boulos M, Brignardello-Petersen R, Chan M, Charide R, Colunga-Lozano L, Dearness K, Darzi A, Hussein H, Karam S, Kolb P, Mansour R, Morgano G, Morsi R, Muti-Schünemann G, Nadim M, Noori A, Philip B, Piggott T, Qiu Y, Benitez Y, Schünemann F, Stevens A, Solo K, Wiercioch W, Mustafa R, Nieuwlaat R. American Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary. Blood Advances 2025, 9: 1247-1260. PMID: 39437797, PMCID: PMC11950770, DOI: 10.1182/bloodadvances.2024014219.
- Stempel J, Wang R, Lee A, Zeidan A, Ma X, Podoltsev N. Initial management of patients with acquired aplastic anemia in the United States: results from a large national claims database. Annals Of Hematology 2025, 104: 2507-2515. PMID: 40102305, PMCID: PMC12052795, DOI: 10.1007/s00277-025-06307-z.
- Chaar C, Chan S, Lee A, Bikdeli B, Tiberio G, Chopard R, Weinberg I, Yamashita Y, Nikandish R, Monreal M. Intercontinental variations in the presentation and management of venous thromboembolism. JVS-Vascular Insights 2025, 3: 100201. DOI: 10.1016/j.jvsvi.2025.100201.
- Ali S, Chan S, Brahmandam A, Xu Y, Deng Y, Elbadawy A, Lee A, Ochoa Chaar C. The Incidence and Significance of Iliac Vein Stenosis in Patients with Deep Vein Thrombosis. Annals Of Vascular Surgery 2024, 111: 310-318. PMID: 39617297, DOI: 10.1016/j.avsg.2024.11.016.
- Restrepo-Espinosa V, Lee A, Prozora S, Patel P, Nassiri N. In-human clinical experience with direct stick embolization of low-flow vascular malformations using a mammalian target of rapamycin inhibitor. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2024, 13: 101997. PMID: 39515753, PMCID: PMC12014304, DOI: 10.1016/j.jvsv.2024.101997.
- Ito S, Chetlapalli K, Wang D, Potnis K, Richmond R, Krumholz H, Lee A, Cuker A, Goshua G. Cost-effectiveness of iptacopan for paroxysmal nocturnal hemoglobinuria. Blood 2024, 145: 127-140. PMID: 39374533, PMCID: PMC11738035, DOI: 10.1182/blood.2024025176.
- Dizman N, Bakouny Z, Haykal T, Riano I, Desai A, Butt A, Basu A, Zhao D, Saad E, Saliby R, Gosain R, Gosain R, Ardeshir F, Deng L, Matt-Amaral L, Arnaoutakis K, Bekaii-Saab T, Manochakian R, Marshall A, Forde P, Murphy M, Subbiah V, Chavez-MacGregor M, Owonikoko T, Lopes G, Aggarwal C, Lee A, Choueiri T. Guide to Understanding and Supporting International Medical Graduates in Hematology/Oncology by the ASCO International Medical Graduates Community of Practice. JCO Oncology Practice 2024, 21: 292-299. PMID: 39374449, PMCID: PMC12455576, DOI: 10.1200/op-24-00565.
- Qureshy Z, Nair P, Vesely S, King A, Lee A, Connell N, von Drygalski A, Wong-Sefidan I, Murphy M, Mistry R, Zon R, Reid E, Fritz J, Park S. Evaluating the impact of a year-long external mentorship pilot program in classical hematology. Blood Advances 2024, 8: 4833-4844. PMID: 39087874, PMCID: PMC11416643, DOI: 10.1182/bloodadvances.2024013218.
- Gu S, Butt A, Schulz V, Rinder H, Lee A, Gallagher P, Hwa J, Bona R. Phenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies. Blood Cells Molecules And Diseases 2024, 110: 102893. PMID: 39260211, DOI: 10.1016/j.bcmd.2024.102893.
- Allen C, Heskel M, Butt A, Tormey C, Pine A, Lee A, Gautam S. Factor VIII Levels and ISTH Disseminated Intravascular Coagulation Scores Do Not Distinguish Disseminated Intravascular Coagulation from the Coagulopathy of Liver Disease. Acta Haematologica 2024, 148: 220-225. PMID: 39004080, PMCID: PMC12106121, DOI: 10.1159/000540239.
- Prince E, Feder K, Calhoun C, Lee A, Carroll C, Restrepo V, Van Doren L. Trainees’ perspectives on sickle cell education: a qualitative needs assessment. BMC Medical Education 2024, 24: 715. PMID: 38956512, PMCID: PMC11220977, DOI: 10.1186/s12909-024-05696-5.
- Ito S, Wang D, Purcell A, Chetlapalli K, Lee A, Cuker A, Goshua G. Cost‐effectiveness of sutimlimab in cold agglutinin disease. American Journal Of Hematology 2024, 99: 1475-1484. PMID: 38733355, DOI: 10.1002/ajh.27358.
- Butt A, Christian J, Kress A, Lu B, Hurwitz M, Goldberg S, Podoltsev N, Gilkes L, Lee A. Providing 0.1 Full-Time Equivalent (FTE) Support to Fellowship Core Faculty Improves Faculty Involvement in Fellowship Education and Recruitment. Journal Of Cancer Education 2024, 39: 325-334. PMID: 38430454, PMCID: PMC12279297, DOI: 10.1007/s13187-024-02414-z.
- Rodriguez P, Brahmandam A, Turner J, Lee A, Chaar C. Endovascular treatment of renal vein thrombosis in a young patient with lung transplant. Journal Of Vascular Surgery Cases And Innovative Techniques 2024, 10: 101437. PMID: 38464891, PMCID: PMC10924198, DOI: 10.1016/j.jvscit.2024.101437.
- Chase M, Drews R, Zumberg M, Ellis L, Reid E, Gerds A, Lee A, Hobbs G, Berry J, Freed J. Consensus Recommendations on Peripheral Blood Smear Review: Defining Curricular Standards and Fellow Competency. Blood Advances 2023, 7: 3244-3252. PMID: 36930800, PMCID: PMC10336252, DOI: 10.1182/bloodadvances.2023009843.
- Lee A, Masselink LE, De Castro LM, Marshall AL, Connell NT, Dent GA, Fritz J, Homer M, Lucas TL, Naik RP, Nelson M, O'Connell C, Rajasekhar A, Reynolds R, Sharma D, Smith M, Weeks LD, Erikson CE. Burnout in U.S. hematologists and oncologists: impact of compensation models and advanced practice provider support. Blood Advances 2023, 7: 3058-3068. PMID: 35476017, PMCID: PMC10331414, DOI: 10.1182/bloodadvances.2021006140.
- Al-Samkari H, Panch S, Lee A. Please Do Call Us Classical Hematologists. The Hematologist 2023, 20 DOI: 10.1182/hem.v20.4.202347.
- Allen C, Gautam S, Cheng W, Pine A, Podoltsev N, Zeidan A, Lee A, Shallis R. Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome. Acta Haematologica 2023, 146: 287-292. PMID: 37166332, PMCID: PMC12106122, DOI: 10.1159/000530153.
- Goshua G, Lee A. Summiting thrombotic hazards in glioma. Blood 2023, 141: 1245-1246. PMID: 36929442, DOI: 10.1182/blood.2022019020.
- Goshua G, Bendapudi P, Lee A. Thrombosis questions from the inpatient wards. Hematology 2022, 2022: 481-490. PMID: 36485139, PMCID: PMC9819989, DOI: 10.1182/hematology.2022000384.
- Butt A, Mankbadi M, Erikson C, Marshall A, Masselink LE, Tong G, Hafler J, Podoltsev N, Lee AI. Bias Against International Medical Graduates in the Hematology/Oncology Fellowship Recruitment Process: Findings From a Nationwide Survey of Fellowship Program Directors. JCO Oncology Practice 2022, 18: 783-787. PMID: 36108253, DOI: 10.1200/op.22.00219.
- Butt A, Erkan D, Lee A. COVID-19 and antiphospholipid antibodies. Best Practice & Research Clinical Haematology 2022, 35: 101402. PMID: 36494152, PMCID: PMC9568270, DOI: 10.1016/j.beha.2022.101402.
- Stempel JM, Podoltsev NA, Zeidan AM, Lee AI, Shallis RM. Concealed by the convenient: acquired von Willebrand syndrome in myeloproliferative neoplasm requires a thorough evaluation. Annals Of Hematology 2022, 101: 2559-2561. PMID: 35984499, DOI: 10.1007/s00277-022-04943-3.
- Butt A, Muradashvili T, Soliman S, Li F, Burns AJ, Brooks A, Browning S, Bar N, Borgman G, Goshua G, Hwa J, Martin K, Rinder H, Tormey C, Pine AB, Bona RD, Lee AI, Neparidze N. Association of iron infusion reactions with ABO blood type. European Journal Of Haematology 2022, 109: 519-525. PMID: 35871468, DOI: 10.1111/ejh.13838.
- Al-Samkari H, Loren AW, Lee AI. The case for classical haematology: the impact of a name and the future of a field. The Lancet Haematology 2022, 9: e455-e459. PMID: 35500590, DOI: 10.1016/s2352-3026(22)00096-5.
- Tyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.
- Lee EJ, Lee AI. Cerebral venous sinus thrombosis after vaccination: the UK experience. The Lancet 2021, 398: 1107-1109. PMID: 34370974, PMCID: PMC8346246, DOI: 10.1016/s0140-6736(21)01788-8.
- Pischel L, Geirsson A, Magaldi J, Martinello RA, Lee AI. A Brewing Back Pain. The New England Journal Of Medicine 2021, 385: 66-72. PMID: 34192434, PMCID: PMC9273048, DOI: 10.1056/nejmcps2034802.
- McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee A, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. Journal Of Hepatology 2021, 75: 647-658. PMID: 33991637, PMCID: PMC8285256, DOI: 10.1016/j.jhep.2021.04.050.
- Ma L, Sahu S, Cano M, Kuppuswamy V, Bajwa J, McPhatter J, Pine A, Meizlish M, Goshua G, Chang C, Zhang H, Price C, Bahel P, Rinder H, Lei T, Day A, Reynolds D, Wu X, Schriefer R, Rauseo A, Goss C, O’Halloran J, Presti R, Kim A, Gelman A, Dela Cruz C, Lee A, Mudd P, Chun H, Atkinson J, Kulkarni H. Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection. Science Immunology 2021, 6: eabh2259. PMID: 34446527, PMCID: PMC8158979, DOI: 10.1126/sciimmunol.abh2259.
- Goshua G, Sinha P, Hendrickson J, Tormey C, Bendapudi PK, Lee AI. Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura. Blood 2020, 137: 969-976. PMID: 33280030, PMCID: PMC7918179, DOI: 10.1182/blood.2020006052.
- Odio CD, O'Brien CR, Jacox J, Jain D, Lee AI. Cryptic Cachexia. The New England Journal Of Medicine 2020, 383: 68-74. PMID: 32609985, DOI: 10.1056/nejmcps1817531.
- Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/s2352-3026(20)30216-7.
- Schwartz AR, Siegel MD, Lee AI. A novel approach to the program evaluation committee. BMC Medical Education 2019, 19: 465. PMID: 31842868, PMCID: PMC6916454, DOI: 10.1186/s12909-019-1899-x.
- Lee AI, Connors JM. The next(gen) step in coagulation testing. Blood 2019, 134: 2002-2003. PMID: 31805193, DOI: 10.1182/blood.2019001414.
- Sharma D, Wallace N, Levinsohn EA, Marshall AL, Kayoumi K, Madero J, Homer M, Reynolds R, Hafler J, Podoltsev NA, Lee AI. Trends and factors affecting the US adult hematology workforce: a mixed methods study. Blood Advances 2019, 3: 3550-3561. PMID: 31738829, PMCID: PMC6880914, DOI: 10.1182/bloodadvances.2019000307.
- Masselink LE, Erikson CE, Connell NT, De Castro LM, Dent GA, Marshall AL, Naik RP, Nelson M, O’Connell C, Rajasekhar A, Sharma D, Smith M, Lee AI. Associations between hematology/oncology fellows’ training and mentorship experiences and hematology-only career plans. Blood Advances 2019, 3: 3278-3286. PMID: 31698456, PMCID: PMC6855099, DOI: 10.1182/bloodadvances.2019000569.
- Djulbegovic M, Dugdale LS, Lee AI. Evaluation of Polycythemia: A Teachable Moment. JAMA Internal Medicine 2018, 178: 128-130. PMID: 29131894, DOI: 10.1001/jamainternmed.2017.6213.
- Lee A, Lee E. Anticoagulation for Proximal Deep Vein Thrombosis. 2017, 299-313. DOI: 10.1007/978-3-319-65226-9_23.
- Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI. Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances 2017, 1: 1224-1237. PMID: 29296762, PMCID: PMC5728544, DOI: 10.1182/bloodadvances.2017005249.
- Lee A, Tormey C. The Hidden Lesion. The New England Journal Of Medicine 2016, 375: 1199. PMID: 27653584, DOI: 10.1056/nejmc1608553.
- Lee AI, Chaar C. The Hidden Lesion. The New England Journal Of Medicine 2016, 374: 2160-2165. PMID: 27248622, DOI: 10.1056/nejmcps1406615.
- Varughese N, Duong A, Emre S, Xu M, Lee AI. Venting the Spleen. The New England Journal Of Medicine 2013, 369: 1357-1363. PMID: 24088096, DOI: 10.1056/nejmcps1210943.
- Lee AI, Koo S, Vaidya A, Katz JT, Loscalzo J. A Bird's-Eye View of Fever. The New England Journal Of Medicine 2011, 365: 1727-1732. PMID: 22047564, DOI: 10.1056/nejmcps1012518.
- Fugmann S, Lee A, Shockett P, Villey I, Schatz D. The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition. Annual Review Of Immunology 2000, 18: 495-527. PMID: 10837067, DOI: 10.1146/annurev.immunol.18.1.495.
Locations
Classical Hematology
Smilow Cancer Hospital Care Center - Spring Brook Common
240 Indian River Road
Orange, CT 06477
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477
Classical Hematology
Smilow Cancer Hospital Care Center - Spring Brook Common
240 Indian River Road
Orange, CT 06477
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477