- Smilow Cancer Hospital Gastrointestinal Cancers ProgramSmilow Cancer Hospital at Trumbull5520 Park AvenueTrumbull, CT 06611
- Smilow Cancer Hospital Melanoma ProgramSmilow Cancer Hospital at Trumbull5520 Park AvenueTrumbull, CT 06611
- Yale Surgical OncologySmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Yale Surgical OncologyBridgeport Hospital267 Grant StreetBridgeport, CT 06610
Sajid A Khan, MD, FACS, FSSO
Biography
Sajid A. Khan, MD, is a surgical oncologist who treats both malignant (cancer) and premalignant tumors. He specializes in complex general surgical oncology and general surgery, and is dedicated to improving the lives of cancer patients through his clinical practice and research endeavors. He specializes in the surgical management of tumors that affect the pancreas, liver, bile duct, gallbladder, stomach, colon and rectum. He also provides surgery for patients with skin cancer and soft tissue sarcomas.
Dr. Khan believes patients do best when medical professionals work cohesively as a team. He appreciates being able to draw upon the expertise of a variety of specialists to collaborate in identifying the best approach to each patient’s case. He uses minimally invasive surgical techniques whenever possible.
He says one of the most important aspects of his work as a surgeon—especially one who treats cancer—is his ability to develop relationships with patients and their family before any operation. Dr. Khan takes the time to get to know his patients, providing each with a detailed description of their diagnosis and an explanation of how treatment will proceed. He is careful to answer all of their questions about the surgery and other treatments they will undergo as part of their multidisciplinary cancer treatment plan.
“I tell my patients that my care for them is a long-term commitment that extends well beyond the perioperative period,” Dr. Khan says. “I communicate with other cancer specialists in Yale Medicine to provide a comprehensive, team approach to their care.”
As an associate professor of surgery (oncology), Dr. Khan is also devoted to performing research that will help improve care for cancer patients. “I am very passionate about my work studying the tumor biology of cancer metastasis,” he says. He is currently working on research to identify which patients with a limited number of metastases (oligometastasis) will benefit most from curative therapies, including surgery.
Titles
- Associate Professor of Surgery (Oncology)
- Section Chief, Hepato-Pancreato-Biliary (HPB) and Mixed Tumors, Surgery
- Co-Director of Team Science, Yale Center for Clinical Investigation (YCCI)
- Co-Program Leader, Advanced Hepatobiliary Disease, Yale Cancer Center
Education & Training
- Non Degree ProgramYale School of Management, Advanced Emerging Leaders Program (2021)
- Non Degree ProgramYale School of Management, Emerging Leaders Program (2020)
- Fellowship (Clinical)University of Chicago Medical Center (2013)
- Residency (Chief)Oregon Health and Science University (2010)
- ResidencyOregon Health and Science University (2009)
- Fellowship (Research)Memorial Sloan-Kettering Cancer Center (2007)
- ResidencyAlbert Einstein College of Medicine/Montefiore Medical Center (2005)
- MDState University of New York Upstate Medical University, Medicine (2003)
- BSSiena College, Biology (1999)
Languages Spoken
- English
- हिन्दी (Hindi)
- اردو (Urdu)
Additional Information
- Elected Membership: Surgical Biology Club (2024)
- Medical Student Thesis Award (Mentor): Yale Medical School Thesis Committee (2023)
- Top Doctors In America: Castle Connolly (2023)
- Plenary Session Presentation: Society of Surgical Oncology, International Meeting (2023)
- Research Prize, Population Science: Yale Cancer Center Annual Conclave (2023)
- Basic Science Research Second Place: American College of Surgeons Clinical Congress (Medical Student Education) (2022)
- First Prize Research: American College of Surgeons, CT Chapter Meeting (2022)
- Top Doctors in America: Castle Connolly (2022)
- Membership Induction: Society of University Surgeons (2022)
- Platinum Quality Award: Yale New Haven Health, Smilow Cancer Hospital at Bridgeport (2021)
- AB of Surgery, Complex General Surgical Oncology (2015)
- AB of Surgery, Surgery General (2012, recertified: 2022)
- Surgical Biology Club (2024 - Present): Member
- Society of Surgical Oncology (2024 - Present): Committee Member
- Society for Surgery of the Alimentary Tract (2023 - Present): Chair
- Society of University Surgeons (2022 - Present): Representative
- Association for Academic Surgery (2021 - Present): Member
- Society for Surgery of the Alimentary Tract (SSAT), Research Committee (2019 - Present): Committee Member
- Society of Surgical Oncology (SSO), Colorectal Disease Site Working Group (2019 - 2021): Committee Member
- Society for Surgery of the Alimentary Tract (2018 - 2021): Committee Member
- National Comprehensive Cancer Network (NCCN) (2017 - Present): Neuroendocrine Tumor Panel Committee, Member
- Yale School of Medicine (2017 - Present): Admissions Committee, Member
- Shen X, Zhang Y, Li J, Zhou Y, Butensky S, Zhang Y, Cai Z, DeWan A, Khan S, Yan H, Johnson C, Zhu F. OncoSexome: the landscape of sex-based differences in oncologic diseases. Nucleic Acids Research 2024, gkae1003. PMID: 39535034, DOI: 10.1093/nar/gkae1003.
- Lu L, Johnson C, Khan S, Kluger H. 16S rRNA target sequencing of human tumors validates findings of Lachnoclostridium abundance in human melanomas that are heavily CD8+ T-cell infiltrated. European Journal Of Cancer 2024, 115084. PMID: 39477777, DOI: 10.1016/j.ejca.2024.115084.
- Jain A, Morris M, Berardi D, Arora T, Domingo-Almenara X, Paty P, Rattray N, Kerekes D, Lu L, Khan S, Johnson C. Charting the metabolic biogeography of the colorectum in cancer: challenging the right sided versus left sided classification. Molecular Cancer 2024, 23: 211. PMID: 39342363, PMCID: PMC11438248, DOI: 10.1186/s12943-024-02133-5.
- Dudkina N, Park H, Song D, Jain A, Khan S, Flavell R, Johnson C, Palm N, Crawford J. Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway. Cell Chemical Biology 2024 PMID: 39163853, DOI: 10.1016/j.chembiol.2024.07.011.
- Lu L, Zhang Q, Aladelokun O, Berardi D, Shen X, Marin A, Garcia‐Milian R, Roper J, Khan S, Johnson C. Asparagine synthetase and G‐protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer. International Journal Of Cancer 2024, 156: 52-68. PMID: 39039782, PMCID: PMC11537827, DOI: 10.1002/ijc.35104.
- Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancerLu, L, Zhang Q, Shen X, Zhen P, Marin P, Garcia-Milian R, Roper J, Khan S, Johnson C. In press at International Journal of Cancer.
- Aladelokun O, Lu L, Zheng J, Yan H, Jain A, Gibson J, Khan S, Johnson C. Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex. Human Genomics 2024, 18: 67. PMID: 38886847, PMCID: PMC11184737, DOI: 10.1186/s40246-024-00635-3.
- Butensky S, Billingsley K, Khan S. Reasonable expansion of surgical candidates for HCC treatment. Clinical Liver Disease 2024, 23: e0153. PMID: 38720794, PMCID: PMC11078523, DOI: 10.1097/cld.0000000000000153.
- Different patient populations: In reply to Higashi, et al.Khan SA, Kerekes D. JAMA Oncology 2024. 10.1001/jamaoncol.2024.1566.
- Different patient populations: In reply to YorioKhan SA, Kerekes D. JAMA Oncology 2024. doi: 10.1001/jamaoncol.2023.5932
- Kerekes D, Frey A, Prsic E, Tran T, Clune J, Sznol M, Kluger H, Forman H, Becher R, Olino K, Khan S. Immunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US. JAMA Oncology 2024, 10: 342-351. PMID: 38175659, PMCID: PMC10767643, DOI: 10.1001/jamaoncol.2023.6025.
- Frey A, Kerekes D, Khan S, Tran T, Kluger H, Clune J, Ariyan S, Sznol M, Ishizuka J, Olino K. Immunotherapy utilization in stage IIIA melanoma: less may be more. Frontiers In Oncology 2024, 14: 1336441. PMID: 38380358, PMCID: PMC10876869, DOI: 10.3389/fonc.2024.1336441.
- Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanomaSu D, Schoenfeld D, Wael I, Cabrejo R, Baumann R, Rimm D, Khan SA, Halaban R, Kluger H, Olino K, Galan A, Clune J, Kluger H, Clune J. Journal of ImmunoTherapy of Cancer 2024.12(3), e008646. https://doi.org/10.1136/jitc-2023-008646
- Zhang N, Tang W, Torres L, Wang X, Ajaj Y, Zhu L, Luan Y, Zhou H, Wang Y, Zhang D, Kurbatov V, Khan S, Kumar P, Hidalgo A, Wu D, Lu J. Cell surface RNAs control neutrophil recruitment. Cell 2024, 187: 846-860.e17. PMID: 38262409, PMCID: PMC10922858, DOI: 10.1016/j.cell.2023.12.033.
- Phase II Study of Peri-operative Modified FOLFIRINOX in Localized Pancreatic Ductal AdenocarcinomaCecchini M, Salem R, Robert M, Czerniak S, Rajaei M, Townsend J, Blaha O, Zelterman D, Thumar J, Kortmansky J, Zaheer W, Fischbach N, Persico J, Stein S, Khan SA, Cha C, Billingsley K, Kunstman J, Chowdhury S, Tseng R, Mauricio C, Yugawa D, Escobar-Hoyos L, Johung K, Wiess C, Spickard C, Aushev V, Laliotis G, Jurdi A, Liu M, Lacy JA. Phase II Study of Peri-operative Modified FOLFIRINOX in Localized Pancreatic Ductal Adenocarcinoma. In press at JAMA Oncology 2024.
- Prolonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resectionYing L, Ilaga-Ying, Kunstman J, Peters N, Almeida M, Blackburn H, Ferrucci L, Billingsley K, Khan SA, Chhoda A, John N, Salem R, Sharma A, Ahuja N. Prolonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resection. In press at Surgical Oncology Insight 2024.
- Precision Oncology in Gastrointestinal and Colorectal Cancer SurgeryMcDonald H, Kerekes D, Kim J, Khan SA. Precision Oncology in Gastrointestinal and Colorectal Cancer Surgery. In press at Surgical Oncology Clinics of North America. 2024
- Zheng J, Sun B, Berardi D, Lu L, Yan H, Zheng S, Aladelokun O, Xie Y, Cai Y, Pollitt K, Khan S, Johnson C. Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids. Environmental Science And Technology 2023, 57: 21016-21028. PMID: 38064429, DOI: 10.1021/acs.est.3c04844.
- Marks V, Kerekes D, Butensky S, Ahuja N, Johnson C, Turaga K, Khan S. Role of colectomy in the management of appendiceal tumors: a retrospective cohort study. BMC Gastroenterology 2023, 23: 398. PMID: 37978348, PMCID: PMC10655451, DOI: 10.1186/s12876-023-03019-4.
- Morris M, Jain A, Sun B, Kurbatov V, Muca E, Zeng Z, Jin Y, Roper J, Lu J, Paty P, Johnson C, Khan S. Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis. Cancer Letters 2023, 574: 216384. PMID: 37716465, PMCID: PMC10620771, DOI: 10.1016/j.canlet.2023.216384.
- Bakkila B, Marks V, Kerekes D, Kunstman J, Salem R, Billingsley K, Ahuja N, Laurans M, Olino K, Khan S. Impact of COVID-19 on the gastrointestinal surgical oncology patient population. Heliyon 2023, 9: e18459. PMID: 37534012, PMCID: PMC10391949, DOI: 10.1016/j.heliyon.2023.e18459.
- Kerekes D, Frey A, Bakkila B, Kunstman J, Khan S. Surgical treatment of stage IV gastroenteropancreatic neuroendocrine carcinoma: Experience and outcomes in the United States. Journal Of Surgical Oncology 2023, 128: 790-802. PMID: 37435780, DOI: 10.1002/jso.27392.
- Papageorge M, Maina R, King A, Lee V, Baumann R, Pucar D, Ariyan S, Khan S, Weiss S, Clune J, Olino K. The role of imaging and sentinel lymph node biopsy in patients with T3b-T4b melanoma with clinically negative disease. Frontiers In Oncology 2023, 13: 1143354. PMID: 37223678, PMCID: PMC10200883, DOI: 10.3389/fonc.2023.1143354.
- Marks V, Kerekes D, Ahuja N, Turaga K, Khan S. 76 ROLE OF COLECTOMY FOR APPENDICEAL TUMORS. Gastroenterology 2023, 164: s-1442. DOI: 10.1016/s0016-5085(23)04363-9.
- Yan H, Talty R, Jain A, Cai Y, Zheng J, Shen X, Muca E, Paty P, Bosenberg M, Khan S, Johnson C. Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations. Redox Biology 2023, 62: 102699. PMID: 37086630, PMCID: PMC10172914, DOI: 10.1016/j.redox.2023.102699.
- Kerekes D, Sznol J, Khan S, Becher R. Impact of nonmalignant ascites on outcomes of open inguinal hernia repair in the USA. Hernia 2023, 27: 1497-1506. PMID: 37029887, DOI: 10.1007/s10029-023-02790-3.
- Kerekes D, Frey A, Bakkila B, Johnson C, Becher R, Billingsley K, Khan S. Hepatopancreatobiliary malignancies: time to treatment matters. Journal Of Gastrointestinal Oncology 2023, 0: 0-0. PMID: 37201090, PMCID: PMC10186552, DOI: 10.21037/jgo-22-1067.
- Lu L, Ma W, Johnson C, Khan S, Irwin M, Pusztai L. In silico designed mRNA vaccines targeting CA-125 neoantigen in breast and ovarian cancer. Vaccine 2023, 41: 2073-2083. PMID: 36813666, PMCID: PMC10064809, DOI: 10.1016/j.vaccine.2023.02.048.
- Shen X, Ma S, Khan S, Johnson C. Identifying Sex-Specific Cancer Metabolites and Associations to Prognosis. Learning Materials In Biosciences 2023, 271-299. DOI: 10.1007/978-3-031-44256-8_11.
- Cai Y, Shen X, Lu L, Yan H, Huang H, Gaule P, Muca E, Theriot CM, Rattray Z, Rattray NJW, Lu J, Ahuja N, Zhang Y, Paty PB, Khan SA, Johnson CH. Bile acid distributions, sex-specificity, and prognosis in colorectal cancer. Biology Of Sex Differences 2022, 13: 61. PMID: 36274154, PMCID: PMC9590160, DOI: 10.1186/s13293-022-00473-9.
- Kerekes D, Frey A, Becher R, Khan S. Neoadjuvant vs Adjuvant Chemotherapy in Resected Ampullary Carcinoma: A Propensity-Matched Cohort Analysis. Journal Of The American College Of Surgeons 2022, 235: s248-s249. DOI: 10.1097/01.xcs.0000894956.83552.8d.
- Jain A, Morris M, Lin EZ, Khan SA, Ma X, Deziel NC, Godri Pollitt KJ, Johnson CH. Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study. The Science Of The Total Environment 2022, 854: 158716. PMID: 36113793, DOI: 10.1016/j.scitotenv.2022.158716.
- Shen X, Jain A, Aladelokun O, Yan H, Gilbride A, Ferrucci LM, Lu L, Khan SA, Johnson CH. Asparagine, colorectal cancer, and the role of sex, genes, microbes, and diet: A narrative review. Frontiers In Molecular Biosciences 2022, 9: 958666. PMID: 36090030, PMCID: PMC9453556, DOI: 10.3389/fmolb.2022.958666.
- Bakkila BF, Kerekes D, Nunez-Smith M, Billingsley KG, Ahuja N, Wang K, Oladele C, Johnson CH, Khan SA. Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery. JAMA Network Open 2022, 5: e225664. PMID: 35377425, PMCID: PMC8980937, DOI: 10.1001/jamanetworkopen.2022.5664.
- Bakkila B, Kerekes D, Johnson C, Khan S. HSR22-125: Quality of Gastrointestinal Surgical Oncology Care According to Insurance Status. Journal Of The National Comprehensive Cancer Network 2022, 20: hsr22-125. DOI: 10.6004/jnccn.2021.7261.
- Kerekes DM, Khan SA. Lipid Metabolism in Biliary Tract Cancer: A New Therapeutic Target? Annals Of Surgical Oncology 2022, 29: 2750-2751. PMID: 35243594, DOI: 10.1245/s10434-022-11383-w.
- Shen X, Cai Y, Lu L, Huang H, Yan H, Paty PB, Muca E, Ahuja N, Zhang Y, Johnson CH, Khan SA. Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study. Metabolites 2022, 12: 164. PMID: 35208238, PMCID: PMC8875032, DOI: 10.3390/metabo12020164.
- Hasan NM, Sharma A, Ruzgar NM, Deshpande H, Olino K, Khan S, Ahuja N. Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma. Oncotarget 2021, 12: 1566-1579. PMID: 34381562, PMCID: PMC8351604, DOI: 10.18632/oncotarget.28032.
- Shah MH, Goldner WS, Benson AB, Bergsland E, Blaszkowsky LS, Brock P, Chan J, Das S, Dickson PV, Fanta P, Giordano T, Halfdanarson TR, Halperin D, He J, Heaney A, Heslin MJ, Kandeel F, Kardan A, Khan SA, Kuvshinoff BW, Lieu C, Miller K, Pillarisetty VG, Reidy D, Salgado SA, Shaheen S, Soares HP, Soulen MC, Strosberg JR, Sussman CR, Trikalinos NA, Uboha NA, Vijayvergia N, Wong T, Lynn B, Hochstetler C. Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network : JNCCN 2021, 19: 839-868. PMID: 34340212, DOI: 10.6004/jnccn.2021.0032.
- Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, team Y, Ko AI, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid may underlie sex-specific immune responses to COVID-19. Science Signaling 2021, 14: eabf8483. PMID: 34230210, PMCID: PMC8432948, DOI: 10.1126/scisignal.abf8483.
- Zhu G, Su H, Johnson CH, Khan SA, Kluger H, Lu L. Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma. European Journal Of Cancer 2021, 151: 25-34. PMID: 33962358, PMCID: PMC8184628, DOI: 10.1016/j.ejca.2021.03.053.
- Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. 5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING. The EMBO Journal 2021, 40: embj2020106065. PMID: 33615517, PMCID: PMC8013832, DOI: 10.15252/embj.2020106065.
- Zhang Q, Cai Y, Kurbatov V, Khan SA, Lu L, Zhang Y, Johnson CH. Gene Alterations of N6‐Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study. BioMed Research International 2020, 2020: 8826456. PMID: 33415160, PMCID: PMC7769650, DOI: 10.1155/2020/8826456.
- Miccio JA, Talcott WJ, Patel T, Park HS, Cecchini M, Salem RR, Khan SA, Stein S, Kortmansky JS, Lacy J, Narang A, Herman J, Jabbour SK, Hallemeier CL, Johung K, Jethwa KR. Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis. Clinical And Translational Radiation Oncology 2020, 27: 15-23. PMID: 33392398, PMCID: PMC7772693, DOI: 10.1016/j.ctro.2020.12.003.
- Tang S, Liu F, Li Y, Zhao L, Wang X, Khan SA, Chen Y, Zhang Y. Treatment Selection and Survival Outcomes in Locally Advanced Proximal Gastric Cancer: A National Cancer Data Base Analysis. Frontiers In Oncology 2020, 10: 537051. PMID: 33102212, PMCID: PMC7546198, DOI: 10.3389/fonc.2020.537051.
- Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Muca E, Vollmar AKR, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage. Metabolites 2020, 10: 257. PMID: 32575361, PMCID: PMC7345993, DOI: 10.3390/metabo10060257.
- Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. Scientific Reports 2020, 10: 4905. PMID: 32184446, PMCID: PMC7078199, DOI: 10.1038/s41598-020-61851-0.
- Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysmsLiu S, Heller DR, Jean RA, Chiu AS, Khan SA, Dardik A. Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysms. Surgery 2020, 168: 234-236. PMID: 32139140, PMCID: PMC7748368, DOI: 10.1016/j.surg.2020.01.017.
- Heller DR, Nicolson NG, Ahuja N, Khan S, Kunstman JW. Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma Survival. JAMA Surgery 2020, 155: e195047. PMID: 31800002, PMCID: PMC6902102, DOI: 10.1001/jamasurg.2019.5047.
- Kurbatov V, Resio BJ, Cama CA, Heller DR, Cha C, Zhang Y, Lu J, Khan SA. Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases. Journal Of Gastrointestinal Oncology 2020, 11: 76-83. PMID: 32175108, PMCID: PMC7052756, DOI: 10.21037/jgo.2020.01.03.
- Kurbatov V, Khan SA. Exploring Microsatellite Instability (MSI) in Colorectal Cancer at Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST). Annals Of Surgical Oncology 2019, 27: 973-974. PMID: 31788754, DOI: 10.1245/s10434-019-08051-x.
- Sun Y, Mironova V, Chen Y, Lundh EPF, Zhang Q, Cai Y, Vasiliou V, Zhang Y, Garcia-Milian R, Khan SA, Johnson CH. Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon Cancer. Translational Oncology 2019, 13: 42-56. PMID: 31760268, PMCID: PMC6883319, DOI: 10.1016/j.tranon.2019.09.004.
- Heller DR, Jean RA, Khan SA. Lymph Node Status In Reply to Carr. Journal Of The American College Of Surgeons 2019, 229: 516-517. PMID: 31655706, DOI: 10.1016/j.jamcollsurg.2019.07.007.
- Heller DR, Jean RA, Khan SA. Appendiceal Carcinoid Tumors In Reply to Sugarbaker. Journal Of The American College Of Surgeons 2019, 229: 519. PMID: 31655709, DOI: 10.1016/j.jamcollsurg.2019.07.005.
- Miccio JA, Jairam V, Gao S, Augustyn A, Oladeru OT, Onderdonk BE, Chowdhary M, Han D, Khan S, Friedlaender G, Lindskog DM, Desphande HA, Osborn H, Roberts KB, Patel KR. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database. Cureus 2019, 11: e6038. PMID: 31824805, PMCID: PMC6886621, DOI: 10.7759/cureus.6038.
- Uhlig J, Sellers CM, Khan SA, Cha C, Kim HS. Hepatocellular carcinoma: Impact of academic setting and hospital volume on patient survival. Surgical Oncology 2019, 31: 111-118. PMID: 31654956, DOI: 10.1016/j.suronc.2019.10.009.
- Kurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma. The Annals Of Thoracic Surgery 2019, 109: 343-349. PMID: 31568747, DOI: 10.1016/j.athoracsur.2019.08.050.
- Rubinstein JC, Khan SA, Christison‐Lagay E, Cha C. APC mutational patterns in gastric adenocarcinoma are enriched for missense variants with associated decreased survival. Genes Chromosomes And Cancer 2019, 59: 64-68. PMID: 31353684, DOI: 10.1002/gcc.22792.
- Liu Z, Luo JJ, Pei KY, Khan SA, Wang XX, Zhao ZX, Yang M, Johnson CH, Wang XS, Zhang Y. Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy. Gastroenterology Report 2019, 8: 151-157. PMID: 32280475, PMCID: PMC7136710, DOI: 10.1093/gastro/goz033.
- Klemen ND, Wang M, Feingold PL, Cooper K, Pavri SN, Han D, Detterbeck FC, Boffa DJ, Khan SA, Olino K, Clune J, Ariyan S, Salem RR, Weiss SA, Kluger HM, Sznol M, Cha C. Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma. Journal For ImmunoTherapy Of Cancer 2019, 7: 196. PMID: 31340861, PMCID: PMC6657062, DOI: 10.1186/s40425-019-0672-3.
- Wang X, Liu F, Li Y, Tang S, Zhang Y, Chen Y, Khan SA. Comparison on Clinicopathological Features, Treatments and Prognosis between Proximal Gastric Cancer and Distal Gastric Cancer: A National Cancer Data Base Analysis. Journal Of Cancer 2019, 10: 3145-3153. PMID: 31289585, PMCID: PMC6603385, DOI: 10.7150/jca.30371.
- Luo J, Liu Z, Pei KY, Khan SA, Wang X, Yang M, Wang X, Zhang Y. The Role of Bowel Preparation in Open, Minimally Invasive, and Converted-to-Open Colectomy. Journal Of Surgical Research 2019, 242: 183-192. PMID: 31085366, DOI: 10.1016/j.jss.2019.02.039.
- Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid TumorsHeller DR, Jean RA, Luo J, Kurbatov V, Grisotti G, Jacobs D, Chiu AS, Zhang Y, Khan SA. Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors. Journal Of The American College Of Surgeons 2019, 228: 839-851. PMID: 30898583, PMCID: PMC6751559, DOI: 10.1016/j.jamcollsurg.2019.02.050.
- Pavri SN, Han G, Khan S, Han D. Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma? Journal Of Surgical Oncology 2019, 119: 1060-1069. PMID: 30883783, DOI: 10.1002/jso.25445.
- Uhlig J, Sellers CM, Cha C, Khan SA, Lacy J, Stein SM, Kim HS. Intrahepatic Cholangiocarcinoma: Socioeconomic Discrepancies, Contemporary Treatment Approaches and Survival Trends from the National Cancer Database. Annals Of Surgical Oncology 2019, 26: 1993-2000. PMID: 30693451, DOI: 10.1245/s10434-019-07175-4.
- How I Treat Gastric and Esophageal Cancer, Surgery.Khan SA, Kurbatov V, Posner MC. Handbook of Gastrointestinal Cancers: Evidence-Based Treatment and Multidisciplinary Patient Care 2019.
- Blakaj A, Stein SM, Khan SA, Johung KL. Review and current state of radiation therapy for locally advanced pancreatic adenocarcinoma. Journal Of Gastrointestinal Oncology 2018, 9: 1027-1036. PMID: 30603121, PMCID: PMC6286948, DOI: 10.21037/jgo.2018.03.07.
- Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018, 9: 4827. PMID: 30425251, PMCID: PMC6233186, DOI: 10.1038/s41467-018-07303-w.
- Jacobs D, Zhu R, Luo J, Grisotti G, Heller DR, Kurbatov V, Johnson CH, Zhang Y, Khan SA. Defining Early-Onset Colon and Rectal Cancers. Frontiers In Oncology 2018, 8: 504. PMID: 30460196, PMCID: PMC6232522, DOI: 10.3389/fonc.2018.00504.
- Miccio J, Jairam V, Gao S, Augustyn A, Oladeru O, Onderdonk B, Costa J, Han D, Khan S, Friedlaender G, Lindskog D, Deshpande H, Tara H, Osborn H, Roberts K, Patel K. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma: An Analysis of the National Cancer Database (NCDB). International Journal Of Radiation Oncology • Biology • Physics 2018, 102: e335. DOI: 10.1016/j.ijrobp.2018.07.1028.
- Pitroda S, Khodarev N, Huang L, Uppal A, Wightman S, Ganai S, Joseph N, Xue L, Weber C, Segal J, Stack M, Khan S, Paty P, Kaul K, Andrade J, White K, Talamonti M, Posner M, Hellman S, Weichselbaum R. Integrated Molecular Subtyping of Clinical Metastasis: Implications for Defining a Curable Oligometastatic State. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: s12. DOI: 10.1016/j.ijrobp.2018.06.122.
- Impact of Hepatectomy-First in Management of Stage IV Colon Cancer with Synchronous Liver MetastasesKurbatov V, Heller D, Lu J, Khan S. Impact of Hepatectomy-First in Management of Stage IV Colon Cancer with Synchronous Liver Metastases. Journal Of The American College Of Surgeons 2018, 227: s66. DOI: 10.1016/j.jamcollsurg.2018.07.139.
- Kurbatov V, Heller D, Zeng Z, Paty P, Lu J, Khan S. Long Noncoding RNA HOTTIP Is Biomarker for Recurrence after Hepatic Metastasectomy for Colorectal Cancer. Journal Of The American College Of Surgeons 2018, 227: s67. DOI: 10.1016/j.jamcollsurg.2018.07.141.
- Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid TumorsHeller D, Jean R, Kurbatov V, Chiu A, Khan S. Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors. Journal Of The American College Of Surgeons 2018, 227: e218. DOI: 10.1016/j.jamcollsurg.2018.08.590.
- Heller DR, Jean RA, Chiu AS, Feder SI, Kurbatov V, Cha C, Khan SA. Regional Differences in Palliative Care Utilization Among Geriatric Colorectal Cancer Patients Needing Emergent Surgery. Journal Of Gastrointestinal Surgery 2018, 23: 153-162. PMID: 30328071, PMCID: PMC6751557, DOI: 10.1007/s11605-018-3929-0.
- Shah MH, Goldner WS, Halfdanarson TR, Bergsland E, Berlin JD, Halperin D, Chan J, Kulke MH, Benson AB, Blaszkowsky LS, Eads J, Engstrom PF, Fanta P, Giordano T, He J, Heslin MJ, Kalemkerian GP, Kandeel F, Khan SA, Kidwai WZ, Kunz PL, Kuvshinoff BW, Lieu C, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Sussman CA, Trikalinos NA, Uboha NA, Whisenant J, Wong T, Yao JC, Burns JL, Ogba N, Zuccarino-Catania G. NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018. Journal Of The National Comprehensive Cancer Network 2018, 16: 693-702. PMID: 29891520, DOI: 10.6004/jnccn.2018.0056.
- Zhu R, Liu F, Grisotti G, Perez-Irizarry J, Salem RR, Cha CH, Johung KL, Boffa DJ, Zhang Y, Khan SA. Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma. Journal Of Gastrointestinal Oncology 2018, 9: 517-526. PMID: 29998017, PMCID: PMC6006033, DOI: 10.21037/jgo.2018.03.05.
- Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018, 9: 1793. PMID: 29728604, PMCID: PMC5935683, DOI: 10.1038/s41467-018-04278-6.
- Heller D, Jean R, Chiu A, Feder S, Kurbatov V, Cha C, Khan S. 420 - Regional Differences in the Utilization of Palliative Care in Geriatric Colorectal Cancer Patients Requiring Emergent Surgery. Gastroenterology 2018, 154: s-1269. DOI: 10.1016/s0016-5085(18)34158-1.
- Zhu R, Liu F, Grisotti G, Pérez-Irizarry J, Cha CH, Johnson CH, Boffa DJ, Han D, Johung KL, Zhang Y, Khan SA. Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum. Journal Of Gastrointestinal Oncology 2018, 9: 231-240. PMID: 29755761, PMCID: PMC5934147, DOI: 10.21037/jgo.2017.11.12.
- Rattray NJW, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JPA, Johnson CH. Beyond genomics: understanding exposotypes through metabolomics. Human Genomics 2018, 12: 4. PMID: 29373992, PMCID: PMC5787293, DOI: 10.1186/s40246-018-0134-x.
- Gao SJ, Park HS, Corso CD, Rutter CE, Khan SA, Johung KL. Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive surgical margins. Journal Of Gastrointestinal Oncology 2017, 8: 953-961. PMID: 29299354, PMCID: PMC5750177, DOI: 10.21037/jgo.2017.08.12.
- Pan W, Zhu S, Qu K, Meeth K, Cheng J, He K, Ma H, Liao Y, Wen X, Roden C, Tobiasova Z, Wei Z, Zhao J, Liu J, Zheng J, Guo B, Khan SA, Bosenberg M, Flavell RA, Lu J. The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression. Immunity 2017, 47: 284-297.e5. PMID: 28813659, PMCID: PMC5710009, DOI: 10.1016/j.immuni.2017.07.020.
- Rubinstein JC, Majumdar SK, Laskin W, Lazaga F, Prasad ML, Carling T, Khan SA. Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 Deletion. Journal Of The Endocrine Society 2017, 1: 926-930. PMID: 29264543, PMCID: PMC5686645, DOI: 10.1210/js.2016-1089.
- Khan S, Paty P, Zeng Z, Lu J. Prognostic signatures of oligometastasis in colorectal cancer liver metastasis. Journal Of Clinical Oncology 2017, 35: 3588-3588. DOI: 10.1200/jco.2017.35.15_suppl.3588.
- Kole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of Nonadherence to NCCN Guideline Recommendations for the Management of Stage I Anal Canal Cancer. Journal Of The National Comprehensive Cancer Network 2017, 15: 355-362. PMID: 28275036, DOI: 10.6004/jnccn.2017.0035.
- Liu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S, Kyba M, Fan R, Guo S, Lu J. miR-125b promotes MLL-AF9–driven murine acute myeloid leukemia involving a VEGFA-mediated non–cell-intrinsic mechanism. Blood 2017, 129: 1491-1502. PMID: 28053194, PMCID: PMC5356452, DOI: 10.1182/blood-2016-06-721027.
- Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancerKole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancer. Journal of National Comprehensive Cancer Network 2017.
- Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complicationAlkukhun A, Grisotti G, Salem RR, Cha C, Khan SA. Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complication. In press at American College of Surgeons Case Reviews in Surgery 2017.
- Khan SA, Zeng Z, Shia J, Paty PB. EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer. Pathology & Oncology Research 2016, 23: 673-677. PMID: 28025786, PMCID: PMC5451302, DOI: 10.1007/s12253-016-0166-2.
- Khan SA, Morris M, Idrees K, Gimbel MI, Rosenberg S, Zeng Z, Li F, Gan G, Shia J, LaQuaglia MP, Paty PB. Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients. Journal Of Pediatric Surgery 2016, 51: 1812-1817. PMID: 27558481, PMCID: PMC5312708, DOI: 10.1016/j.jpedsurg.2016.07.015.
- Grisotti G, Khan S. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumors. Difficult Decisions In Surgery: An Evidence-Based Approach 2016, 641-653. DOI: 10.1007/978-3-319-27365-5_56.
- Zhu R, Grisotti G, Salem RR, Khan SA. Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer. World Journal Of Surgical Oncology 2015, 14: 12. PMID: 26769110, PMCID: PMC4714509, DOI: 10.1186/s12957-015-0755-7.
- Wightman SC, Uppal A, Pitroda SP, Ganai S, Burnette B, Stack M, Oshima G, Khan S, Huang X, Posner MC, Weichselbaum RR, Khodarev NN. Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome. British Journal Of Cancer 2015, 113: 327-335. PMID: 26042934, PMCID: PMC4506383, DOI: 10.1038/bjc.2015.193.
- Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer TherapeuticsGrisotti G, Khan SA. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer Therapeutics. Difficult Decisions in Hepatobiliary and Pancreatic Surgery – An Evidence Based Approach 2015
- Skin and Subcutaneous TissueKhan SA, Bank J, Choi E, Song D. Skin and Subcutaneous Tissue. Schwartz's Principles of Surgery, Tenth Edition, 2014.
- Lussier Y, Khodarev N, Regan K, Corbin K, Li H, Ganai S, Khan S, Gnerlich J, Darga T, Fan H, Karpenko O, Paty P, Posner M, Chmura S, Hellman S, Ferguson M, Weichselbaum R. Correction: Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs. PLOS ONE 2013, 8: 10.1371/annotation/2489ae5e-3650-4897-8df6-3e974ca585c4. PMCID: PMC3676315, DOI: 10.1371/annotation/2489ae5e-3650-4897-8df6-3e974ca585c4.
- Khan SA, Matthews JB. Intraoperative margin re-resection for colorectal cancer liver metastases. Hepatobiliary Surgery And Nutrition 2013, 2: 108-12. PMID: 24570924, PMCID: PMC3924657, DOI: 10.3978/j.issn.2304-3881.2012.10.16.
- Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich J, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs. PLOS ONE 2012, 7: e50141. PMID: 23251360, PMCID: PMC3518475, DOI: 10.1371/journal.pone.0050141.
- Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR. Tumor Endothelial Inflammation Predicts Clinical Outcome in Diverse Human Cancers. PLOS ONE 2012, 7: e46104. PMID: 23056240, PMCID: PMC3464251, DOI: 10.1371/journal.pone.0046104.
- Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. MicroRNA Expression Characterizes Oligometastasis(es). PLOS ONE 2011, 6: e28650. PMID: 22174856, PMCID: PMC3236765, DOI: 10.1371/journal.pone.0028650.
- Owen RP, Khan SA, Negassa A, Beitler JJ, Bello JA, Brook A, Farinhas J, Garg MK, Haigentz M, Miller TS, Hsu MS, Ravikumar TS, Shifteh K, Smith RV, Silver CE. Radiofrequency ablation of advanced head and neck cancer. Archives Of Otolaryngology--head & Neck Surgery 2011, 137: 493-8. PMID: 21576561, DOI: 10.1001/archoto.2011.62.
- Esemuede I, Forslund A, Khan SA, Qin LX, Gimbel MI, Nash GM, Zeng Z, Rosenberg S, Shia J, Barany F, Paty PB. Improved Testing for Microsatellite Instability in Colorectal Cancer Using a Simplified 3-Marker Assay. Annals Of Surgical Oncology 2010, 17: 3370-3378. PMID: 20703819, PMCID: PMC3269820, DOI: 10.1245/s10434-010-1147-4.
- Cheng Y, Idrees K, Shattock R, Khan SA, Zeng Z, Brennan CW, Paty P, Barany F. Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. International Journal Of Cancer 2010, 127: 568-577. PMID: 19957330, PMCID: PMC3270092, DOI: 10.1002/ijc.25086.
- Cheng YW, Pincas H, Bacolod MD, Schemmann G, Giardina SF, Huang J, Barral S, Idrees K, Khan SA, Zeng Z, Rosenberg S, Notterman DA, Ott J, Paty P, Barany F. CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal Cancer. Clinical Cancer Research 2008, 14: 6005-6013. PMID: 18829479, PMCID: PMC3268558, DOI: 10.1158/1078-0432.ccr-08-0216.
- Zeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT, D’Alessio M, Barany F, Paty PB. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Letters 2008, 265: 258-269. PMID: 18395971, PMCID: PMC4367187, DOI: 10.1016/j.canlet.2008.02.049.
- Khan SA, Idrees K, Forslund A, Zeng Z, Rosenberg S, Pincas H, Barany F, Offit K, LaQuaglia MP, Paty PB. Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer. Journal Of Surgical Oncology 2008, 97: 621-625. PMID: 18381604, PMCID: PMC4381874, DOI: 10.1002/jso.20996.
- Smilow Cancer Hospital Gastrointestinal Cancers ProgramSmilow Cancer Hospital at Trumbull5520 Park AvenueTrumbull, CT 06611
- Smilow Cancer Hospital Melanoma ProgramSmilow Cancer Hospital at Trumbull5520 Park AvenueTrumbull, CT 06611
- Yale Surgical OncologySmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Yale Surgical OncologyBridgeport Hospital267 Grant StreetBridgeport, CT 06610
Biography
Sajid A. Khan, MD, is a surgical oncologist who treats both malignant (cancer) and premalignant tumors. He specializes in complex general surgical oncology and general surgery, and is dedicated to improving the lives of cancer patients through his clinical practice and research endeavors. He specializes in the surgical management of tumors that affect the pancreas, liver, bile duct, gallbladder, stomach, colon and rectum. He also provides surgery for patients with skin cancer and soft tissue sarcomas.
Dr. Khan believes patients do best when medical professionals work cohesively as a team. He appreciates being able to draw upon the expertise of a variety of specialists to collaborate in identifying the best approach to each patient’s case. He uses minimally invasive surgical techniques whenever possible.
He says one of the most important aspects of his work as a surgeon—especially one who treats cancer—is his ability to develop relationships with patients and their family before any operation. Dr. Khan takes the time to get to know his patients, providing each with a detailed description of their diagnosis and an explanation of how treatment will proceed. He is careful to answer all of their questions about the surgery and other treatments they will undergo as part of their multidisciplinary cancer treatment plan.
“I tell my patients that my care for them is a long-term commitment that extends well beyond the perioperative period,” Dr. Khan says. “I communicate with other cancer specialists in Yale Medicine to provide a comprehensive, team approach to their care.”
As an associate professor of surgery (oncology), Dr. Khan is also devoted to performing research that will help improve care for cancer patients. “I am very passionate about my work studying the tumor biology of cancer metastasis,” he says. He is currently working on research to identify which patients with a limited number of metastases (oligometastasis) will benefit most from curative therapies, including surgery.
Titles
- Associate Professor of Surgery (Oncology)
- Section Chief, Hepato-Pancreato-Biliary (HPB) and Mixed Tumors, Surgery
- Co-Director of Team Science, Yale Center for Clinical Investigation (YCCI)
- Co-Program Leader, Advanced Hepatobiliary Disease, Yale Cancer Center
Education & Training
- Non Degree ProgramYale School of Management, Advanced Emerging Leaders Program (2021)
- Non Degree ProgramYale School of Management, Emerging Leaders Program (2020)
- Fellowship (Clinical)University of Chicago Medical Center (2013)
- Residency (Chief)Oregon Health and Science University (2010)
- ResidencyOregon Health and Science University (2009)
- Fellowship (Research)Memorial Sloan-Kettering Cancer Center (2007)
- ResidencyAlbert Einstein College of Medicine/Montefiore Medical Center (2005)
- MDState University of New York Upstate Medical University, Medicine (2003)
- BSSiena College, Biology (1999)
Languages Spoken
- English
- हिन्दी (Hindi)
- اردو (Urdu)
Additional Information
- Elected Membership: Surgical Biology Club (2024)
- Medical Student Thesis Award (Mentor): Yale Medical School Thesis Committee (2023)
- Top Doctors In America: Castle Connolly (2023)
- Plenary Session Presentation: Society of Surgical Oncology, International Meeting (2023)
- Research Prize, Population Science: Yale Cancer Center Annual Conclave (2023)
- Basic Science Research Second Place: American College of Surgeons Clinical Congress (Medical Student Education) (2022)
- First Prize Research: American College of Surgeons, CT Chapter Meeting (2022)
- Top Doctors in America: Castle Connolly (2022)
- Membership Induction: Society of University Surgeons (2022)
- Platinum Quality Award: Yale New Haven Health, Smilow Cancer Hospital at Bridgeport (2021)
- AB of Surgery, Complex General Surgical Oncology (2015)
- AB of Surgery, Surgery General (2012, recertified: 2022)
- Surgical Biology Club (2024 - Present): Member
- Society of Surgical Oncology (2024 - Present): Committee Member
- Society for Surgery of the Alimentary Tract (2023 - Present): Chair
- Society of University Surgeons (2022 - Present): Representative
- Association for Academic Surgery (2021 - Present): Member
- Society for Surgery of the Alimentary Tract (SSAT), Research Committee (2019 - Present): Committee Member
- Society of Surgical Oncology (SSO), Colorectal Disease Site Working Group (2019 - 2021): Committee Member
- Society for Surgery of the Alimentary Tract (2018 - 2021): Committee Member
- National Comprehensive Cancer Network (NCCN) (2017 - Present): Neuroendocrine Tumor Panel Committee, Member
- Yale School of Medicine (2017 - Present): Admissions Committee, Member
- Shen X, Zhang Y, Li J, Zhou Y, Butensky S, Zhang Y, Cai Z, DeWan A, Khan S, Yan H, Johnson C, Zhu F. OncoSexome: the landscape of sex-based differences in oncologic diseases. Nucleic Acids Research 2024, gkae1003. PMID: 39535034, DOI: 10.1093/nar/gkae1003.
- Lu L, Johnson C, Khan S, Kluger H. 16S rRNA target sequencing of human tumors validates findings of Lachnoclostridium abundance in human melanomas that are heavily CD8+ T-cell infiltrated. European Journal Of Cancer 2024, 115084. PMID: 39477777, DOI: 10.1016/j.ejca.2024.115084.
- Jain A, Morris M, Berardi D, Arora T, Domingo-Almenara X, Paty P, Rattray N, Kerekes D, Lu L, Khan S, Johnson C. Charting the metabolic biogeography of the colorectum in cancer: challenging the right sided versus left sided classification. Molecular Cancer 2024, 23: 211. PMID: 39342363, PMCID: PMC11438248, DOI: 10.1186/s12943-024-02133-5.
- Dudkina N, Park H, Song D, Jain A, Khan S, Flavell R, Johnson C, Palm N, Crawford J. Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway. Cell Chemical Biology 2024 PMID: 39163853, DOI: 10.1016/j.chembiol.2024.07.011.
- Lu L, Zhang Q, Aladelokun O, Berardi D, Shen X, Marin A, Garcia‐Milian R, Roper J, Khan S, Johnson C. Asparagine synthetase and G‐protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer. International Journal Of Cancer 2024, 156: 52-68. PMID: 39039782, PMCID: PMC11537827, DOI: 10.1002/ijc.35104.
- Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancerLu, L, Zhang Q, Shen X, Zhen P, Marin P, Garcia-Milian R, Roper J, Khan S, Johnson C. In press at International Journal of Cancer.
- Aladelokun O, Lu L, Zheng J, Yan H, Jain A, Gibson J, Khan S, Johnson C. Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex. Human Genomics 2024, 18: 67. PMID: 38886847, PMCID: PMC11184737, DOI: 10.1186/s40246-024-00635-3.
- Butensky S, Billingsley K, Khan S. Reasonable expansion of surgical candidates for HCC treatment. Clinical Liver Disease 2024, 23: e0153. PMID: 38720794, PMCID: PMC11078523, DOI: 10.1097/cld.0000000000000153.
- Different patient populations: In reply to Higashi, et al.Khan SA, Kerekes D. JAMA Oncology 2024. 10.1001/jamaoncol.2024.1566.
- Different patient populations: In reply to YorioKhan SA, Kerekes D. JAMA Oncology 2024. doi: 10.1001/jamaoncol.2023.5932
- Kerekes D, Frey A, Prsic E, Tran T, Clune J, Sznol M, Kluger H, Forman H, Becher R, Olino K, Khan S. Immunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US. JAMA Oncology 2024, 10: 342-351. PMID: 38175659, PMCID: PMC10767643, DOI: 10.1001/jamaoncol.2023.6025.
- Frey A, Kerekes D, Khan S, Tran T, Kluger H, Clune J, Ariyan S, Sznol M, Ishizuka J, Olino K. Immunotherapy utilization in stage IIIA melanoma: less may be more. Frontiers In Oncology 2024, 14: 1336441. PMID: 38380358, PMCID: PMC10876869, DOI: 10.3389/fonc.2024.1336441.
- Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanomaSu D, Schoenfeld D, Wael I, Cabrejo R, Baumann R, Rimm D, Khan SA, Halaban R, Kluger H, Olino K, Galan A, Clune J, Kluger H, Clune J. Journal of ImmunoTherapy of Cancer 2024.12(3), e008646. https://doi.org/10.1136/jitc-2023-008646
- Zhang N, Tang W, Torres L, Wang X, Ajaj Y, Zhu L, Luan Y, Zhou H, Wang Y, Zhang D, Kurbatov V, Khan S, Kumar P, Hidalgo A, Wu D, Lu J. Cell surface RNAs control neutrophil recruitment. Cell 2024, 187: 846-860.e17. PMID: 38262409, PMCID: PMC10922858, DOI: 10.1016/j.cell.2023.12.033.
- Phase II Study of Peri-operative Modified FOLFIRINOX in Localized Pancreatic Ductal AdenocarcinomaCecchini M, Salem R, Robert M, Czerniak S, Rajaei M, Townsend J, Blaha O, Zelterman D, Thumar J, Kortmansky J, Zaheer W, Fischbach N, Persico J, Stein S, Khan SA, Cha C, Billingsley K, Kunstman J, Chowdhury S, Tseng R, Mauricio C, Yugawa D, Escobar-Hoyos L, Johung K, Wiess C, Spickard C, Aushev V, Laliotis G, Jurdi A, Liu M, Lacy JA. Phase II Study of Peri-operative Modified FOLFIRINOX in Localized Pancreatic Ductal Adenocarcinoma. In press at JAMA Oncology 2024.
- Prolonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resectionYing L, Ilaga-Ying, Kunstman J, Peters N, Almeida M, Blackburn H, Ferrucci L, Billingsley K, Khan SA, Chhoda A, John N, Salem R, Sharma A, Ahuja N. Prolonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resection. In press at Surgical Oncology Insight 2024.
- Precision Oncology in Gastrointestinal and Colorectal Cancer SurgeryMcDonald H, Kerekes D, Kim J, Khan SA. Precision Oncology in Gastrointestinal and Colorectal Cancer Surgery. In press at Surgical Oncology Clinics of North America. 2024
- Zheng J, Sun B, Berardi D, Lu L, Yan H, Zheng S, Aladelokun O, Xie Y, Cai Y, Pollitt K, Khan S, Johnson C. Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids. Environmental Science And Technology 2023, 57: 21016-21028. PMID: 38064429, DOI: 10.1021/acs.est.3c04844.
- Marks V, Kerekes D, Butensky S, Ahuja N, Johnson C, Turaga K, Khan S. Role of colectomy in the management of appendiceal tumors: a retrospective cohort study. BMC Gastroenterology 2023, 23: 398. PMID: 37978348, PMCID: PMC10655451, DOI: 10.1186/s12876-023-03019-4.
- Morris M, Jain A, Sun B, Kurbatov V, Muca E, Zeng Z, Jin Y, Roper J, Lu J, Paty P, Johnson C, Khan S. Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis. Cancer Letters 2023, 574: 216384. PMID: 37716465, PMCID: PMC10620771, DOI: 10.1016/j.canlet.2023.216384.
- Bakkila B, Marks V, Kerekes D, Kunstman J, Salem R, Billingsley K, Ahuja N, Laurans M, Olino K, Khan S. Impact of COVID-19 on the gastrointestinal surgical oncology patient population. Heliyon 2023, 9: e18459. PMID: 37534012, PMCID: PMC10391949, DOI: 10.1016/j.heliyon.2023.e18459.
- Kerekes D, Frey A, Bakkila B, Kunstman J, Khan S. Surgical treatment of stage IV gastroenteropancreatic neuroendocrine carcinoma: Experience and outcomes in the United States. Journal Of Surgical Oncology 2023, 128: 790-802. PMID: 37435780, DOI: 10.1002/jso.27392.
- Papageorge M, Maina R, King A, Lee V, Baumann R, Pucar D, Ariyan S, Khan S, Weiss S, Clune J, Olino K. The role of imaging and sentinel lymph node biopsy in patients with T3b-T4b melanoma with clinically negative disease. Frontiers In Oncology 2023, 13: 1143354. PMID: 37223678, PMCID: PMC10200883, DOI: 10.3389/fonc.2023.1143354.
- Marks V, Kerekes D, Ahuja N, Turaga K, Khan S. 76 ROLE OF COLECTOMY FOR APPENDICEAL TUMORS. Gastroenterology 2023, 164: s-1442. DOI: 10.1016/s0016-5085(23)04363-9.
- Yan H, Talty R, Jain A, Cai Y, Zheng J, Shen X, Muca E, Paty P, Bosenberg M, Khan S, Johnson C. Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations. Redox Biology 2023, 62: 102699. PMID: 37086630, PMCID: PMC10172914, DOI: 10.1016/j.redox.2023.102699.
- Kerekes D, Sznol J, Khan S, Becher R. Impact of nonmalignant ascites on outcomes of open inguinal hernia repair in the USA. Hernia 2023, 27: 1497-1506. PMID: 37029887, DOI: 10.1007/s10029-023-02790-3.
- Kerekes D, Frey A, Bakkila B, Johnson C, Becher R, Billingsley K, Khan S. Hepatopancreatobiliary malignancies: time to treatment matters. Journal Of Gastrointestinal Oncology 2023, 0: 0-0. PMID: 37201090, PMCID: PMC10186552, DOI: 10.21037/jgo-22-1067.
- Lu L, Ma W, Johnson C, Khan S, Irwin M, Pusztai L. In silico designed mRNA vaccines targeting CA-125 neoantigen in breast and ovarian cancer. Vaccine 2023, 41: 2073-2083. PMID: 36813666, PMCID: PMC10064809, DOI: 10.1016/j.vaccine.2023.02.048.
- Shen X, Ma S, Khan S, Johnson C. Identifying Sex-Specific Cancer Metabolites and Associations to Prognosis. Learning Materials In Biosciences 2023, 271-299. DOI: 10.1007/978-3-031-44256-8_11.
- Cai Y, Shen X, Lu L, Yan H, Huang H, Gaule P, Muca E, Theriot CM, Rattray Z, Rattray NJW, Lu J, Ahuja N, Zhang Y, Paty PB, Khan SA, Johnson CH. Bile acid distributions, sex-specificity, and prognosis in colorectal cancer. Biology Of Sex Differences 2022, 13: 61. PMID: 36274154, PMCID: PMC9590160, DOI: 10.1186/s13293-022-00473-9.
- Kerekes D, Frey A, Becher R, Khan S. Neoadjuvant vs Adjuvant Chemotherapy in Resected Ampullary Carcinoma: A Propensity-Matched Cohort Analysis. Journal Of The American College Of Surgeons 2022, 235: s248-s249. DOI: 10.1097/01.xcs.0000894956.83552.8d.
- Jain A, Morris M, Lin EZ, Khan SA, Ma X, Deziel NC, Godri Pollitt KJ, Johnson CH. Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study. The Science Of The Total Environment 2022, 854: 158716. PMID: 36113793, DOI: 10.1016/j.scitotenv.2022.158716.
- Shen X, Jain A, Aladelokun O, Yan H, Gilbride A, Ferrucci LM, Lu L, Khan SA, Johnson CH. Asparagine, colorectal cancer, and the role of sex, genes, microbes, and diet: A narrative review. Frontiers In Molecular Biosciences 2022, 9: 958666. PMID: 36090030, PMCID: PMC9453556, DOI: 10.3389/fmolb.2022.958666.
- Bakkila BF, Kerekes D, Nunez-Smith M, Billingsley KG, Ahuja N, Wang K, Oladele C, Johnson CH, Khan SA. Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery. JAMA Network Open 2022, 5: e225664. PMID: 35377425, PMCID: PMC8980937, DOI: 10.1001/jamanetworkopen.2022.5664.
- Bakkila B, Kerekes D, Johnson C, Khan S. HSR22-125: Quality of Gastrointestinal Surgical Oncology Care According to Insurance Status. Journal Of The National Comprehensive Cancer Network 2022, 20: hsr22-125. DOI: 10.6004/jnccn.2021.7261.
- Kerekes DM, Khan SA. Lipid Metabolism in Biliary Tract Cancer: A New Therapeutic Target? Annals Of Surgical Oncology 2022, 29: 2750-2751. PMID: 35243594, DOI: 10.1245/s10434-022-11383-w.
- Shen X, Cai Y, Lu L, Huang H, Yan H, Paty PB, Muca E, Ahuja N, Zhang Y, Johnson CH, Khan SA. Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study. Metabolites 2022, 12: 164. PMID: 35208238, PMCID: PMC8875032, DOI: 10.3390/metabo12020164.
- Hasan NM, Sharma A, Ruzgar NM, Deshpande H, Olino K, Khan S, Ahuja N. Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma. Oncotarget 2021, 12: 1566-1579. PMID: 34381562, PMCID: PMC8351604, DOI: 10.18632/oncotarget.28032.
- Shah MH, Goldner WS, Benson AB, Bergsland E, Blaszkowsky LS, Brock P, Chan J, Das S, Dickson PV, Fanta P, Giordano T, Halfdanarson TR, Halperin D, He J, Heaney A, Heslin MJ, Kandeel F, Kardan A, Khan SA, Kuvshinoff BW, Lieu C, Miller K, Pillarisetty VG, Reidy D, Salgado SA, Shaheen S, Soares HP, Soulen MC, Strosberg JR, Sussman CR, Trikalinos NA, Uboha NA, Vijayvergia N, Wong T, Lynn B, Hochstetler C. Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network : JNCCN 2021, 19: 839-868. PMID: 34340212, DOI: 10.6004/jnccn.2021.0032.
- Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, team Y, Ko AI, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid may underlie sex-specific immune responses to COVID-19. Science Signaling 2021, 14: eabf8483. PMID: 34230210, PMCID: PMC8432948, DOI: 10.1126/scisignal.abf8483.
- Zhu G, Su H, Johnson CH, Khan SA, Kluger H, Lu L. Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma. European Journal Of Cancer 2021, 151: 25-34. PMID: 33962358, PMCID: PMC8184628, DOI: 10.1016/j.ejca.2021.03.053.
- Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. 5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING. The EMBO Journal 2021, 40: embj2020106065. PMID: 33615517, PMCID: PMC8013832, DOI: 10.15252/embj.2020106065.
- Zhang Q, Cai Y, Kurbatov V, Khan SA, Lu L, Zhang Y, Johnson CH. Gene Alterations of N6‐Methyladenosine (m6A) Regulators in Colorectal Cancer: A TCGA Database Study. BioMed Research International 2020, 2020: 8826456. PMID: 33415160, PMCID: PMC7769650, DOI: 10.1155/2020/8826456.
- Miccio JA, Talcott WJ, Patel T, Park HS, Cecchini M, Salem RR, Khan SA, Stein S, Kortmansky JS, Lacy J, Narang A, Herman J, Jabbour SK, Hallemeier CL, Johung K, Jethwa KR. Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis. Clinical And Translational Radiation Oncology 2020, 27: 15-23. PMID: 33392398, PMCID: PMC7772693, DOI: 10.1016/j.ctro.2020.12.003.
- Tang S, Liu F, Li Y, Zhao L, Wang X, Khan SA, Chen Y, Zhang Y. Treatment Selection and Survival Outcomes in Locally Advanced Proximal Gastric Cancer: A National Cancer Data Base Analysis. Frontiers In Oncology 2020, 10: 537051. PMID: 33102212, PMCID: PMC7546198, DOI: 10.3389/fonc.2020.537051.
- Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Muca E, Vollmar AKR, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage. Metabolites 2020, 10: 257. PMID: 32575361, PMCID: PMC7345993, DOI: 10.3390/metabo10060257.
- Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. Scientific Reports 2020, 10: 4905. PMID: 32184446, PMCID: PMC7078199, DOI: 10.1038/s41598-020-61851-0.
- Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysmsLiu S, Heller DR, Jean RA, Chiu AS, Khan SA, Dardik A. Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysms. Surgery 2020, 168: 234-236. PMID: 32139140, PMCID: PMC7748368, DOI: 10.1016/j.surg.2020.01.017.
- Heller DR, Nicolson NG, Ahuja N, Khan S, Kunstman JW. Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma Survival. JAMA Surgery 2020, 155: e195047. PMID: 31800002, PMCID: PMC6902102, DOI: 10.1001/jamasurg.2019.5047.
- Kurbatov V, Resio BJ, Cama CA, Heller DR, Cha C, Zhang Y, Lu J, Khan SA. Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases. Journal Of Gastrointestinal Oncology 2020, 11: 76-83. PMID: 32175108, PMCID: PMC7052756, DOI: 10.21037/jgo.2020.01.03.
- Kurbatov V, Khan SA. Exploring Microsatellite Instability (MSI) in Colorectal Cancer at Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST). Annals Of Surgical Oncology 2019, 27: 973-974. PMID: 31788754, DOI: 10.1245/s10434-019-08051-x.
- Sun Y, Mironova V, Chen Y, Lundh EPF, Zhang Q, Cai Y, Vasiliou V, Zhang Y, Garcia-Milian R, Khan SA, Johnson CH. Molecular Pathway Analysis Indicates a Distinct Metabolic Phenotype in Women With Right-Sided Colon Cancer. Translational Oncology 2019, 13: 42-56. PMID: 31760268, PMCID: PMC6883319, DOI: 10.1016/j.tranon.2019.09.004.
- Heller DR, Jean RA, Khan SA. Lymph Node Status In Reply to Carr. Journal Of The American College Of Surgeons 2019, 229: 516-517. PMID: 31655706, DOI: 10.1016/j.jamcollsurg.2019.07.007.
- Heller DR, Jean RA, Khan SA. Appendiceal Carcinoid Tumors In Reply to Sugarbaker. Journal Of The American College Of Surgeons 2019, 229: 519. PMID: 31655709, DOI: 10.1016/j.jamcollsurg.2019.07.005.
- Miccio JA, Jairam V, Gao S, Augustyn A, Oladeru OT, Onderdonk BE, Chowdhary M, Han D, Khan S, Friedlaender G, Lindskog DM, Desphande HA, Osborn H, Roberts KB, Patel KR. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database. Cureus 2019, 11: e6038. PMID: 31824805, PMCID: PMC6886621, DOI: 10.7759/cureus.6038.
- Uhlig J, Sellers CM, Khan SA, Cha C, Kim HS. Hepatocellular carcinoma: Impact of academic setting and hospital volume on patient survival. Surgical Oncology 2019, 31: 111-118. PMID: 31654956, DOI: 10.1016/j.suronc.2019.10.009.
- Kurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma. The Annals Of Thoracic Surgery 2019, 109: 343-349. PMID: 31568747, DOI: 10.1016/j.athoracsur.2019.08.050.
- Rubinstein JC, Khan SA, Christison‐Lagay E, Cha C. APC mutational patterns in gastric adenocarcinoma are enriched for missense variants with associated decreased survival. Genes Chromosomes And Cancer 2019, 59: 64-68. PMID: 31353684, DOI: 10.1002/gcc.22792.
- Liu Z, Luo JJ, Pei KY, Khan SA, Wang XX, Zhao ZX, Yang M, Johnson CH, Wang XS, Zhang Y. Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy. Gastroenterology Report 2019, 8: 151-157. PMID: 32280475, PMCID: PMC7136710, DOI: 10.1093/gastro/goz033.
- Klemen ND, Wang M, Feingold PL, Cooper K, Pavri SN, Han D, Detterbeck FC, Boffa DJ, Khan SA, Olino K, Clune J, Ariyan S, Salem RR, Weiss SA, Kluger HM, Sznol M, Cha C. Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma. Journal For ImmunoTherapy Of Cancer 2019, 7: 196. PMID: 31340861, PMCID: PMC6657062, DOI: 10.1186/s40425-019-0672-3.
- Wang X, Liu F, Li Y, Tang S, Zhang Y, Chen Y, Khan SA. Comparison on Clinicopathological Features, Treatments and Prognosis between Proximal Gastric Cancer and Distal Gastric Cancer: A National Cancer Data Base Analysis. Journal Of Cancer 2019, 10: 3145-3153. PMID: 31289585, PMCID: PMC6603385, DOI: 10.7150/jca.30371.
- Luo J, Liu Z, Pei KY, Khan SA, Wang X, Yang M, Wang X, Zhang Y. The Role of Bowel Preparation in Open, Minimally Invasive, and Converted-to-Open Colectomy. Journal Of Surgical Research 2019, 242: 183-192. PMID: 31085366, DOI: 10.1016/j.jss.2019.02.039.
- Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid TumorsHeller DR, Jean RA, Luo J, Kurbatov V, Grisotti G, Jacobs D, Chiu AS, Zhang Y, Khan SA. Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors. Journal Of The American College Of Surgeons 2019, 228: 839-851. PMID: 30898583, PMCID: PMC6751559, DOI: 10.1016/j.jamcollsurg.2019.02.050.
- Pavri SN, Han G, Khan S, Han D. Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma? Journal Of Surgical Oncology 2019, 119: 1060-1069. PMID: 30883783, DOI: 10.1002/jso.25445.
- Uhlig J, Sellers CM, Cha C, Khan SA, Lacy J, Stein SM, Kim HS. Intrahepatic Cholangiocarcinoma: Socioeconomic Discrepancies, Contemporary Treatment Approaches and Survival Trends from the National Cancer Database. Annals Of Surgical Oncology 2019, 26: 1993-2000. PMID: 30693451, DOI: 10.1245/s10434-019-07175-4.
- How I Treat Gastric and Esophageal Cancer, Surgery.Khan SA, Kurbatov V, Posner MC. Handbook of Gastrointestinal Cancers: Evidence-Based Treatment and Multidisciplinary Patient Care 2019.
- Blakaj A, Stein SM, Khan SA, Johung KL. Review and current state of radiation therapy for locally advanced pancreatic adenocarcinoma. Journal Of Gastrointestinal Oncology 2018, 9: 1027-1036. PMID: 30603121, PMCID: PMC6286948, DOI: 10.21037/jgo.2018.03.07.
- Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018, 9: 4827. PMID: 30425251, PMCID: PMC6233186, DOI: 10.1038/s41467-018-07303-w.
- Jacobs D, Zhu R, Luo J, Grisotti G, Heller DR, Kurbatov V, Johnson CH, Zhang Y, Khan SA. Defining Early-Onset Colon and Rectal Cancers. Frontiers In Oncology 2018, 8: 504. PMID: 30460196, PMCID: PMC6232522, DOI: 10.3389/fonc.2018.00504.
- Miccio J, Jairam V, Gao S, Augustyn A, Oladeru O, Onderdonk B, Costa J, Han D, Khan S, Friedlaender G, Lindskog D, Deshpande H, Tara H, Osborn H, Roberts K, Patel K. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma: An Analysis of the National Cancer Database (NCDB). International Journal Of Radiation Oncology • Biology • Physics 2018, 102: e335. DOI: 10.1016/j.ijrobp.2018.07.1028.
- Pitroda S, Khodarev N, Huang L, Uppal A, Wightman S, Ganai S, Joseph N, Xue L, Weber C, Segal J, Stack M, Khan S, Paty P, Kaul K, Andrade J, White K, Talamonti M, Posner M, Hellman S, Weichselbaum R. Integrated Molecular Subtyping of Clinical Metastasis: Implications for Defining a Curable Oligometastatic State. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: s12. DOI: 10.1016/j.ijrobp.2018.06.122.
- Impact of Hepatectomy-First in Management of Stage IV Colon Cancer with Synchronous Liver MetastasesKurbatov V, Heller D, Lu J, Khan S. Impact of Hepatectomy-First in Management of Stage IV Colon Cancer with Synchronous Liver Metastases. Journal Of The American College Of Surgeons 2018, 227: s66. DOI: 10.1016/j.jamcollsurg.2018.07.139.
- Kurbatov V, Heller D, Zeng Z, Paty P, Lu J, Khan S. Long Noncoding RNA HOTTIP Is Biomarker for Recurrence after Hepatic Metastasectomy for Colorectal Cancer. Journal Of The American College Of Surgeons 2018, 227: s67. DOI: 10.1016/j.jamcollsurg.2018.07.141.
- Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid TumorsHeller D, Jean R, Kurbatov V, Chiu A, Khan S. Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors. Journal Of The American College Of Surgeons 2018, 227: e218. DOI: 10.1016/j.jamcollsurg.2018.08.590.
- Heller DR, Jean RA, Chiu AS, Feder SI, Kurbatov V, Cha C, Khan SA. Regional Differences in Palliative Care Utilization Among Geriatric Colorectal Cancer Patients Needing Emergent Surgery. Journal Of Gastrointestinal Surgery 2018, 23: 153-162. PMID: 30328071, PMCID: PMC6751557, DOI: 10.1007/s11605-018-3929-0.
- Shah MH, Goldner WS, Halfdanarson TR, Bergsland E, Berlin JD, Halperin D, Chan J, Kulke MH, Benson AB, Blaszkowsky LS, Eads J, Engstrom PF, Fanta P, Giordano T, He J, Heslin MJ, Kalemkerian GP, Kandeel F, Khan SA, Kidwai WZ, Kunz PL, Kuvshinoff BW, Lieu C, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Sussman CA, Trikalinos NA, Uboha NA, Whisenant J, Wong T, Yao JC, Burns JL, Ogba N, Zuccarino-Catania G. NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018. Journal Of The National Comprehensive Cancer Network 2018, 16: 693-702. PMID: 29891520, DOI: 10.6004/jnccn.2018.0056.
- Zhu R, Liu F, Grisotti G, Perez-Irizarry J, Salem RR, Cha CH, Johung KL, Boffa DJ, Zhang Y, Khan SA. Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma. Journal Of Gastrointestinal Oncology 2018, 9: 517-526. PMID: 29998017, PMCID: PMC6006033, DOI: 10.21037/jgo.2018.03.05.
- Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018, 9: 1793. PMID: 29728604, PMCID: PMC5935683, DOI: 10.1038/s41467-018-04278-6.
- Heller D, Jean R, Chiu A, Feder S, Kurbatov V, Cha C, Khan S. 420 - Regional Differences in the Utilization of Palliative Care in Geriatric Colorectal Cancer Patients Requiring Emergent Surgery. Gastroenterology 2018, 154: s-1269. DOI: 10.1016/s0016-5085(18)34158-1.
- Zhu R, Liu F, Grisotti G, Pérez-Irizarry J, Cha CH, Johnson CH, Boffa DJ, Han D, Johung KL, Zhang Y, Khan SA. Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum. Journal Of Gastrointestinal Oncology 2018, 9: 231-240. PMID: 29755761, PMCID: PMC5934147, DOI: 10.21037/jgo.2017.11.12.
- Rattray NJW, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JPA, Johnson CH. Beyond genomics: understanding exposotypes through metabolomics. Human Genomics 2018, 12: 4. PMID: 29373992, PMCID: PMC5787293, DOI: 10.1186/s40246-018-0134-x.
- Gao SJ, Park HS, Corso CD, Rutter CE, Khan SA, Johung KL. Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive surgical margins. Journal Of Gastrointestinal Oncology 2017, 8: 953-961. PMID: 29299354, PMCID: PMC5750177, DOI: 10.21037/jgo.2017.08.12.
- Pan W, Zhu S, Qu K, Meeth K, Cheng J, He K, Ma H, Liao Y, Wen X, Roden C, Tobiasova Z, Wei Z, Zhao J, Liu J, Zheng J, Guo B, Khan SA, Bosenberg M, Flavell RA, Lu J. The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression. Immunity 2017, 47: 284-297.e5. PMID: 28813659, PMCID: PMC5710009, DOI: 10.1016/j.immuni.2017.07.020.
- Rubinstein JC, Majumdar SK, Laskin W, Lazaga F, Prasad ML, Carling T, Khan SA. Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 Deletion. Journal Of The Endocrine Society 2017, 1: 926-930. PMID: 29264543, PMCID: PMC5686645, DOI: 10.1210/js.2016-1089.
- Khan S, Paty P, Zeng Z, Lu J. Prognostic signatures of oligometastasis in colorectal cancer liver metastasis. Journal Of Clinical Oncology 2017, 35: 3588-3588. DOI: 10.1200/jco.2017.35.15_suppl.3588.
- Kole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of Nonadherence to NCCN Guideline Recommendations for the Management of Stage I Anal Canal Cancer. Journal Of The National Comprehensive Cancer Network 2017, 15: 355-362. PMID: 28275036, DOI: 10.6004/jnccn.2017.0035.
- Liu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S, Kyba M, Fan R, Guo S, Lu J. miR-125b promotes MLL-AF9–driven murine acute myeloid leukemia involving a VEGFA-mediated non–cell-intrinsic mechanism. Blood 2017, 129: 1491-1502. PMID: 28053194, PMCID: PMC5356452, DOI: 10.1182/blood-2016-06-721027.
- Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancerKole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancer. Journal of National Comprehensive Cancer Network 2017.
- Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complicationAlkukhun A, Grisotti G, Salem RR, Cha C, Khan SA. Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complication. In press at American College of Surgeons Case Reviews in Surgery 2017.
- Khan SA, Zeng Z, Shia J, Paty PB. EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer. Pathology & Oncology Research 2016, 23: 673-677. PMID: 28025786, PMCID: PMC5451302, DOI: 10.1007/s12253-016-0166-2.
- Khan SA, Morris M, Idrees K, Gimbel MI, Rosenberg S, Zeng Z, Li F, Gan G, Shia J, LaQuaglia MP, Paty PB. Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients. Journal Of Pediatric Surgery 2016, 51: 1812-1817. PMID: 27558481, PMCID: PMC5312708, DOI: 10.1016/j.jpedsurg.2016.07.015.
- Grisotti G, Khan S. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumors. Difficult Decisions In Surgery: An Evidence-Based Approach 2016, 641-653. DOI: 10.1007/978-3-319-27365-5_56.
- Zhu R, Grisotti G, Salem RR, Khan SA. Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer. World Journal Of Surgical Oncology 2015, 14: 12. PMID: 26769110, PMCID: PMC4714509, DOI: 10.1186/s12957-015-0755-7.
- Wightman SC, Uppal A, Pitroda SP, Ganai S, Burnette B, Stack M, Oshima G, Khan S, Huang X, Posner MC, Weichselbaum RR, Khodarev NN. Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome. British Journal Of Cancer 2015, 113: 327-335. PMID: 26042934, PMCID: PMC4506383, DOI: 10.1038/bjc.2015.193.
- Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer TherapeuticsGrisotti G, Khan SA. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer Therapeutics. Difficult Decisions in Hepatobiliary and Pancreatic Surgery – An Evidence Based Approach 2015
- Skin and Subcutaneous TissueKhan SA, Bank J, Choi E, Song D. Skin and Subcutaneous Tissue. Schwartz's Principles of Surgery, Tenth Edition, 2014.
- Lussier Y, Khodarev N, Regan K, Corbin K, Li H, Ganai S, Khan S, Gnerlich J, Darga T, Fan H, Karpenko O, Paty P, Posner M, Chmura S, Hellman S, Ferguson M, Weichselbaum R. Correction: Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs. PLOS ONE 2013, 8: 10.1371/annotation/2489ae5e-3650-4897-8df6-3e974ca585c4. PMCID: PMC3676315, DOI: 10.1371/annotation/2489ae5e-3650-4897-8df6-3e974ca585c4.
- Khan SA, Matthews JB. Intraoperative margin re-resection for colorectal cancer liver metastases. Hepatobiliary Surgery And Nutrition 2013, 2: 108-12. PMID: 24570924, PMCID: PMC3924657, DOI: 10.3978/j.issn.2304-3881.2012.10.16.
- Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich J, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs. PLOS ONE 2012, 7: e50141. PMID: 23251360, PMCID: PMC3518475, DOI: 10.1371/journal.pone.0050141.
- Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR. Tumor Endothelial Inflammation Predicts Clinical Outcome in Diverse Human Cancers. PLOS ONE 2012, 7: e46104. PMID: 23056240, PMCID: PMC3464251, DOI: 10.1371/journal.pone.0046104.
- Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. MicroRNA Expression Characterizes Oligometastasis(es). PLOS ONE 2011, 6: e28650. PMID: 22174856, PMCID: PMC3236765, DOI: 10.1371/journal.pone.0028650.
- Owen RP, Khan SA, Negassa A, Beitler JJ, Bello JA, Brook A, Farinhas J, Garg MK, Haigentz M, Miller TS, Hsu MS, Ravikumar TS, Shifteh K, Smith RV, Silver CE. Radiofrequency ablation of advanced head and neck cancer. Archives Of Otolaryngology--head & Neck Surgery 2011, 137: 493-8. PMID: 21576561, DOI: 10.1001/archoto.2011.62.
- Esemuede I, Forslund A, Khan SA, Qin LX, Gimbel MI, Nash GM, Zeng Z, Rosenberg S, Shia J, Barany F, Paty PB. Improved Testing for Microsatellite Instability in Colorectal Cancer Using a Simplified 3-Marker Assay. Annals Of Surgical Oncology 2010, 17: 3370-3378. PMID: 20703819, PMCID: PMC3269820, DOI: 10.1245/s10434-010-1147-4.
- Cheng Y, Idrees K, Shattock R, Khan SA, Zeng Z, Brennan CW, Paty P, Barany F. Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. International Journal Of Cancer 2010, 127: 568-577. PMID: 19957330, PMCID: PMC3270092, DOI: 10.1002/ijc.25086.
- Cheng YW, Pincas H, Bacolod MD, Schemmann G, Giardina SF, Huang J, Barral S, Idrees K, Khan SA, Zeng Z, Rosenberg S, Notterman DA, Ott J, Paty P, Barany F. CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal Cancer. Clinical Cancer Research 2008, 14: 6005-6013. PMID: 18829479, PMCID: PMC3268558, DOI: 10.1158/1078-0432.ccr-08-0216.
- Zeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT, D’Alessio M, Barany F, Paty PB. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Letters 2008, 265: 258-269. PMID: 18395971, PMCID: PMC4367187, DOI: 10.1016/j.canlet.2008.02.049.
- Khan SA, Idrees K, Forslund A, Zeng Z, Rosenberg S, Pincas H, Barany F, Offit K, LaQuaglia MP, Paty PB. Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer. Journal Of Surgical Oncology 2008, 97: 621-625. PMID: 18381604, PMCID: PMC4381874, DOI: 10.1002/jso.20996.
- Smilow Cancer Hospital Gastrointestinal Cancers ProgramSmilow Cancer Hospital at Trumbull5520 Park AvenueTrumbull, CT 06611
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- Yale Surgical OncologySmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Yale Surgical OncologyBridgeport Hospital267 Grant StreetBridgeport, CT 06610
- Smilow Cancer Hospital Gastrointestinal Cancers ProgramSmilow Cancer Hospital at Trumbull5520 Park AvenueTrumbull, CT 06611
- Smilow Cancer Hospital Melanoma ProgramSmilow Cancer Hospital at Trumbull5520 Park AvenueTrumbull, CT 06611
- Yale Surgical OncologySmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Yale Surgical OncologyBridgeport Hospital267 Grant StreetBridgeport, CT 06610