- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477
Robert Bona, MD
Biography
Robert Bona, MD, is a Yale Cancer Center hematologist. He cares for individuals with blood disorders, including those with excessive bleeding or clotting, those with low red blood cell (anemia), low platelet, or white cell counts, and those with disorders of iron metabolism. He is medical director of the Yale Hemophilia Treatment Center.
Dr. Bona says he has been interested in blood disorders since medical school, where he studied with some of the top experts in the field. “I’ve always been interested in looking at blood cells under the microscope and studying blood coagulation and clotting,” he says.
As a Yale Medicine clinician, he often works with teams that include advanced practitioners, nurses, and other specialized physicians from medicine, laboratory medicine, and transfusion medicine, as well as medical providers from related areas such as surgery and radiology.
For those individuals asking for advice or care, he suggests they come to their visit with a sense of what they want to talk about. “Come with an agenda. It might be to discuss your diagnosis, treatment for your disease, or other diagnostic possibilities if the diagnosis has not yet been made,” he says. If you are coming from a medical center with a different medical record system, making your complete medical record available is important to have an optimal visit. It also helps, if you wish, to bring a family member or friend to talk to us about complex medical issues.”
In addition to his clinical work, Dr. Bona is a professor of medicine (hematology) at Yale School of Medicine. He has strong interests in medical education and research interests in new treatments for people with bleeding or clotting disorders. “The education and training of our next generation of physicians and medical educators is very important to me,” he says.
Prior to coming to Yale, Dr. Bona was a founding faculty member of the Frank H. Netter MD School of Medicine at Quinnipiac University. Prior to that, he worked in the Hematology-Oncology division at the University of Connecticut.
Titles
- Professor of Medicine (Hematology)
- Professor of Medicine, Hematology
- Medical Director, Hemophilia Treatment Center
Education & Training
- Non Degree ProgramUniversity of MA, Instructional Design-Certificate (2013)
- Fellow Hematology-OncologyUniversity of Connecticut (1986)
- Intern-ResidentBrown University-Rhode Island Hospital (1983)
- MDSUNY Upstate Medical Center (1980)
Additional Information
- AB of Internal Medicine, Hematology (Internal Medicine) (1986, recertified: 2015)
- AB of Internal Medicine, Medical Oncology (1985)
- AB of Internal Medicine, Internal Medicine (1983)
- Glaeser-Khan S, Ito S, Sra M, Richmond R, Bona R, Krumholz H, Croteau S, Cuker A, Goshua G. Emicizumab for preventing intracranial hemorrhage in infants with severe hemophilia A: a cost-effectiveness analysis. Blood Advances 2025, 9: 6237-6245. PMID: 40795232, PMCID: PMC12744270, DOI: 10.1182/bloodadvances.2025016822.
- Wilson M, Hsia C, Rowan K, Huang S, Ng T, Zypchen L, Bona R, Dehghan N, Chen L. Successful treatment of Kimura disease with Mycophenolate Mofetil: a report of two cases and review of the literature. Rheumatology International 2025, 45: 224. PMID: 40924180, DOI: 10.1007/s00296-025-05985-2.
- Ito S, Potnis K, Harvey J, Sra M, Bewersdorf J, Bona R, Krumholz H, Cuker A, Pandya A, Goshua G. Cost-effectiveness of prophylactic weekly efanesoctocog alfa versus standard-care factor VIII in patients with severe hemophilia A. Annals Of Internal Medicine 2025, 178: 819-828. PMID: 40258278, PMCID: PMC12170149, DOI: 10.7326/annals-24-02749.
- Gu S, Bona R, Hwa J. Technology Spotlight New Dimensions for Platelet Evaluation in Hematology Diagnostics. The Hematologist 2025, 22 DOI: 10.1182/hem.v22.3.202538.
- Gu S, Butt A, Schulz V, Rinder H, Lee A, Gallagher P, Hwa J, Bona R. Phenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies. Blood Cells Molecules And Diseases 2024, 110: 102893. PMID: 39260211, DOI: 10.1016/j.bcmd.2024.102893.
- Waldron C, Ito S, Wang D, Allen C, Viswanathan G, Bona R, Cuker A, Goshua G. Cost-effectiveness of prophylaxis with recombinant vs plasma-derived VWF in severe von Willebrand disease in the United States. Blood 2024, 143: 2332-2335. PMID: 38635764, PMCID: PMC11862817, DOI: 10.1182/blood.2024024209.
- Chiari J, Prozora S, Feinn R, Louizos E, Gallagher P, Bona R. Joint bleeds in mild hemophilia: Prevalence and clinical characteristics. Haemophilia 2024, 30: 331-335. PMID: 38240020, DOI: 10.1111/hae.14939.
- Potnis K, Viswanathan G, Bona R, Ito S, Kempton C, Pandya A, Krumholz H, Goshua G. Cost‐effectiveness of prophylactic emicizumab versus prophylactic recombinant factor VIII in patients with moderate or mild hemophilia A without inhibitors in the United States. American Journal Of Hematology 2023, 98: e247-e250. PMID: 37401660, DOI: 10.1002/ajh.27014.
- Meizlish ML, Goshua G, Liu Y, Fine R, Amin K, Chang E, DeFilippo N, Keating C, Liu Y, Mankbadi M, McManus D, Wang SY, Price C, Bona RD, Chaar C, Chun HJ, Pine AB, Rinder HM, Siner JM, Neuberg DS, Owusu KA, Lee AI. Intermediate‐dose anticoagulation, aspirin, and in‐hospital mortality in COVID‐19: A propensity score‐matched analysis. American Journal Of Hematology 2021, 96: 471-479. PMID: 33476420, PMCID: PMC8013588, DOI: 10.1002/ajh.26102.
- Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/s2352-3026(20)30216-7.
- Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM, Miorin L, Olmo EMD, Alon A, Delaforge E, Hennecker CD, Wang G, Pottel J, Bona R, Smith N, Hall JM, Shapiro G, Clark H, Mittermaier A, Kruse AC, García-Sastre A, Roth BL, Glasspool-Malone J, Francone V, Hertzog N, Fremont-Smith M, Ricke DO. COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms. Research Square 2020 PMID: 32702719, PMCID: PMC7336703, DOI: 10.21203/rs.3.rs-30934/v2.
- Yu E, Feinn R, Bona R, Brink B, Sindhar S, Kozel B, Pober B. Mild macrocytosis in Williams-Beuren syndrome. European Journal Of Medical Genetics 2019, 63: 103740. PMID: 31419598, DOI: 10.1016/j.ejmg.2019.103740.
- Usmani S, Choquette L, Bona R, Feinn R, Shahid Z, Lalla RV. Transient bacteremia induced by dental cleaning is not associated with infection of central venous catheters in patients with cancer. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 2018, 125: 286-294. PMID: 29428697, PMCID: PMC5944361, DOI: 10.1016/j.oooo.2017.12.022.
- Bona R. Hypercoagulable States What the Oral Surgeon Needs to Know. Oral And Maxillofacial Surgery Clinics Of North America 2016, 28: 491-495. PMID: 27745619, DOI: 10.1016/j.coms.2016.06.002.
- Metersky ML, Eldridge N, Wang Y, Jaser L, Bona R, Eckenrode S, Bakullari A, Andrawis M, Classen D, Krumholz HM. Predictors of warfarin‐associated adverse events in hospitalized patients: Opportunities to prevent patient harm. Journal Of Hospital Medicine 2015, 11: 276-282. PMID: 26662851, DOI: 10.1002/jhm.2528.
- Selinger HA, Ballesteros E, Bona R. Concurrent polycythemia vera and chronic lymphocytic leukemia: treatment response to pegylated interferon alpha 2a. American Journal Of Hematology 2013, 88: 535-6. PMID: 23553722, DOI: 10.1002/ajh.23449.
- Bockorny M, Chakravarty S, Schulman P, Bockorny B, Bona R. Severe Heart Failure after Bortezomib Treatment in a Patient with Multiple Myeloma: A Case Report and Review of the Literature. Acta Haematologica 2012, 128: 244-247. PMID: 22964848, DOI: 10.1159/000340050.
- Bona R. ACP Journal Club: review: factor Xa inhibitors reduce DVT more than LMWH in total knee or hip replacement. Annals Of Internal Medicine 2012, 157: jc2-5. PMID: 22910959, DOI: 10.7326/0003-4819-157-4-201208210-02005.
- Linkins L, Dans A, Moores L, Bona R, Davidson B, Schulman S, Crowther M. Treatment and Prevention of Heparin-Induced Thrombocytopenia Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012, 141: e495s-e530s. PMID: 22315270, PMCID: PMC3278058, DOI: 10.1378/chest.11-2303.
- Liu B, Yang Y, Qiu Z, Staron M, Hong F, Li Y, Wu S, Li Y, Hao B, Bona R, Han D, Li Z. Erratum: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nature Communications 2012, 3: 653. PMCID: PMC3464422, DOI: 10.1038/ncomms1398.
- Staron M, Wu S, Hong F, Stojanovic A, Du X, Bona R, Liu B, Li Z. Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex. Blood 2011, 117: 7136-7144. PMID: 21576699, PMCID: PMC3143555, DOI: 10.1182/blood-2011-01-330464.
- Bendel S, Bona R, Baker W. Dabigatran: an oral direct thrombin inhibitor for use in atrial fibrillation. Advances In Therapy 2011, 28: 460. PMID: 21533567, DOI: 10.1007/s12325-011-0025-1.
- Usmani S, Bona R, Chiosis G, Li Z. The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1. Journal Of Hematology & Oncology 2010, 3: 40. PMID: 20977755, PMCID: PMC2974653, DOI: 10.1186/1756-8722-3-40.
- Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperoneLiu B, Yang Y, Qiu Z, Staron M, Hong F, Li Y, Wu S, Li Y, Hao B, Bona R, Han D, Li Z. Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nature Communications 2010, 1: 79. PMID: 20865800, PMCID: PMC2982182, DOI: 10.1038/ncomms1070.
- Odesina V, Bellini S, Leger R, Bona R, Delaney C, Andemariam B, Bacarro N, Lundquist K, Donahoe S, D'Angelo S, Gorenbeyn A, Goodrich S, Tafas C. Evidence‐Based Sickle Cell Pain Management in the Emergency Department. Advanced Emergency Nursing Journal 2010, 32: 102-111. DOI: 10.1097/tme.0b013e3181da588c.
- Roper N, Storer B, Bona R, Fang M. Validation and Comparison of Pharmacogenetics-Based Warfarin Dosing Algorithms for Application of Pharmacogenetic Testing. Journal Of Molecular Diagnostics 2010, 12: 283-291. PMID: 20228265, PMCID: PMC2860463, DOI: 10.2353/jmoldx.2010.090110.
- Usmani S, Bona R, Li Z. 17 AAG for HSP90 inhibition in cancer--from bench to bedside. 2009, 9: 654-64. PMID: 19601813, DOI: 10.2174/156652409788488757.
- Aglieco F, Manickaratnam S, Bona R, Kaplan A. A Case Report of Refractory Warm Autoimmune Hemolytic Anemia Treated With Plasmapheresis and Rituximab. Therapeutic Apheresis And Dialysis 2008, 12: 185-189. PMID: 18387171, DOI: 10.1111/j.1744-9987.2008.00568.x.
- Kapadia P, Bona R. Acquired deficiency of vitamin K-dependent clotting factors due to brodifacoum ingestion. Connecticut Medicine 2008, 72: 207-9. PMID: 18478986.
- Shafique S, Bona R, Kaplan A. A Case Report of Therapeutic Leukapheresis in an Adult With Chronic Myelogenous Leukemia Presenting With Hyperleukocytosis and Leukostasis. Therapeutic Apheresis And Dialysis 2007, 11: 146-149. PMID: 17381536, DOI: 10.1111/j.1744-9987.2007.00417.x.
- Li Z, Qiao Y, Liu B, Laska E, Chakravarthi P, Kulko J, Bona R, Fang M, Hegde U, Moyo V, Tannenbaum S, Ménoret A, Gaffney J, Glynn L, Runowicz C, Srivastava P. Combination of Imatinib Mesylate with Autologous Leukocyte-Derived Heat Shock Protein and Chronic Myelogenous Leukemia. Clinical Cancer Research 2005, 11: 4460-4468. PMID: 15958631, DOI: 10.1158/1078-0432.ccr-05-0250.
- Bona R. Central line thrombosis in patients with cancer. Current Opinion In Pulmonary Medicine 2003, 9: 362-366. PMID: 12904704, DOI: 10.1097/00063198-200309000-00004.
- Tutschka P, Bilgrami S, Feingold J, Edwards R, Bona R, Naqvi B, Clive J. Cytoreduction and Stem Cell Mobilization with a Regimen of Paclitaxel, Etoposide and Cyclophosphamide Followed by Autologous Transplantation Using a Preparative Regimen of Busulfan, Etoposide and Cyclophosphamide for Patients with Advanced Lymphoma. Acta Haematologica 2001, 105: 222-232. PMID: 11528096, DOI: 10.1159/000046569.
- Naqvi B, Dorsky D, Ali S, Feingold J, Edwards R, Bona R, Clive J, Tutschka P, Bilgrami S. Efficacy of Clarithromycin in Preventing Viridans Streptococcal Bacteremia following autologous Stem Cell Transplantation. Infection 2001, 29: 201-204. PMID: 11545480, DOI: 10.1007/s15010-001-1028-7.
- Bilgrami S, Bona R, Edwards R, Li Z, Naqvi B, Shaikh A, Furlong F, Fox J, Clive J, Tutschka P. Dexamethasone, paclitaxel, etoposide, cyclophosphamide (d-TEC) and G-CSF for stem cell mobilisation in multiple myeloma. Bone Marrow Transplantation 2001, 28: 137-143. PMID: 11509931, DOI: 10.1038/sj.bmt.1703126.
- Saif M, Bona R, Greenberg B. AIDS and Thrombosis: Retrospective Study of 131 HIV-Infected Patients. AIDS Patient Care And STDs 2001, 15: 311-320. PMID: 11445013, DOI: 10.1089/108729101750279687.
- Bilgrami S, Metersky M, McNally D, Naqvi B, Kapur D, Raible D, Bona R, Edwards R, Feingold J, Clive J, Tutschka P. Idiopathic Pneumonia Syndrome following Myeloablative Chemotherapy and Autologous Transplantation. Annals Of Pharmacotherapy 2001, 35: 196-201. PMID: 11215840, DOI: 10.1345/aph.10071.
- Bilgrami S, Feingold J, Kapur D, Bona R, Edwards R, Khan A, Rodriguez-Pinero F, Tutschka P. Correspondence: A Novel Combination of Paclitaxel, Etoposide, and Cyclophosphamide for Stem Cell Mobilization and Tumor Cytoreduction in Ovarian Cancer. Stem Cells And Development 2000, 9: 133-135. PMID: 10813526, DOI: 10.1089/152581600319342.
- Bona R, Hickey A, Wallace D. Warfarin Is Safe as Secondary Prophylaxis in Patients With Cancer and a Previous Episode of Venous Thrombosis. American Journal Of Clinical Oncology 2000, 23: 71-73. PMID: 10683083, DOI: 10.1097/00000421-200002000-00020.
- Bilgrami S, Feingold J, Bona R, Edwards R, Khan A, Rodriguez-Pinero F, Khan I, Kazierad D, Clive J, Tutschka P. Dose-intense paclitaxel, etoposide and cyclophosphamide: a safe and active regimen for tumor cytoreduction and stem cell mobilization in metastatic breast cancer. Bone Marrow Transplantation 2000, 25: 123-130. PMID: 10673668, DOI: 10.1038/sj.bmt.1702125.
- Kapur D, Dorsky D, Feingold J, Bona R, Edwards R, Aslanzadeh J, Tutschka P, Bilgrami S. Incidence and outcome of vancomycin-resistant enterococcal bacteremia following autologous peripheral blood stem cell transplantation. Bone Marrow Transplantation 2000, 25: 147-152. PMID: 10673672, DOI: 10.1038/sj.bmt.1702123.
- de Medeiros B, Rezuke W, Ricci A, Tsongalis G, Shen P, Bona R, Feingold J, Edwards R, Tutschka P, Bilgrami S. Kaposi’s Sarcoma following Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia. Acta Haematologica 2000, 104: 115-118. PMID: 11154986, DOI: 10.1159/000039743.
- Bilgrami S, Edwards R, Bona R, Kazierad D, Furlong F, Fox J, Clive J, Naqvi B, Tutschka P. A Pilot Study of Busulfan, Cyclophosphamide and Etoposide Followed by Autologous Transplantation for Acute Myeloid Leukemia in Remission. Acta Haematologica 2000, 104: 144-147. PMID: 11154994, DOI: 10.1159/000039751.
- Bilgrami S, Aslanzadeh J, Feingold J, Bona R, Clive J, Dorsky D, Edwards R, Tutschka P. Cytomegalovirus viremia, viruria and disease after autologous peripheral blood stem cell transplantation: no need for surveillance. Bone Marrow Transplantation 1999, 24: 69-73. PMID: 10435738, DOI: 10.1038/sj.bmt.1701827.
- Bilgrami S, Feingold J, Dorsky D, Edwards R, Bona R, Khan A, Rodriguez-Pinero F, Clive J, Tutschka P. Incidence and outcome of Clostridium difficile infection following autologous peripheral blood stem cell transplantation. Bone Marrow Transplantation 1999, 23: 1039-1042. PMID: 10373070, DOI: 10.1038/sj.bmt.1701773.
- Bona R. Thrombotic Complications of Central Venous Catheters in Cancer Patients. Seminars In Thrombosis And Hemostasis 1999, 25: 147-155. PMID: 10357082, DOI: 10.1055/s-2007-994916.
- Bilgrami S, Chakraborty N, Rodriguez-Pinero F, Khan A, Feingold J, Bona R, Edwards R, Dorsky D, Clive J, Mukherji B, Tutschka P. Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. Bone Marrow Transplantation 1999, 23: 469-474. PMID: 10100561, DOI: 10.1038/sj.bmt.1701594.
- Schindler J, Bona R, Chen H, Feingold J, Edwards R, Tutschka P, Bilgrami S. Regional Thrombolysis with Urokinase for Central Venous Catheter-related Thrombosis in Patients Undergoing High-dose Chemotherapy with Autologous Blood Stem Cell Rescue. Clinical And Applied Thrombosis/Hemostasis 1999, 5: 25-29. PMID: 10725979, DOI: 10.1177/107602969900500106.
- Feingold J, Bilgrami S, Edwards R, Bona R, Tutschka P. #703 High dose mobilization chemotherapy followed by myeloblative therapy with stem cell support for the treatment of small, round, blue cell tumors. Journal Of Pediatric Hematology/Oncology 1998, 20: 412. DOI: 10.1097/00043426-199807000-00140.
- Heit J, Berkowitz S, Bona R, Cabanas V, Corson J, Elliott C, Lyons R. Efficacy and Safety of Low Molecular Weight Heparin (Ardeparin Sodium) Compared to Warfarin for the Prevention of Venous Thromboembolism after Total Knee Replacement Surgery: A Double-blind, Dose-ranging Study. Thrombosis And Haemostasis 1997, 77: 032-038. PMID: 9031445, DOI: 10.1055/s-0038-1655902.
- Bona R, Hickey A, Wallace D. Efficacy and Safety of Oral Anticoagulation in Patients with Cancer. Thrombosis And Haemostasis 1997, 78: 137-140. PMID: 9198143, DOI: 10.1055/s-0038-1657516.
- de Souza M, Nulsen J, Sequenzia L, Bona R, Walker F, Luciano A. The Effect of Medroxyprogesterone Acetate on Conjugated Equine Estrogen-Induced Changes in Coagulation Parameters in Postmenopausal Women. Journal Of Women's Health 1996, 5: 121-128. DOI: 10.1089/jwh.1996.5.121.
- Bona R, Hickey A, Greenwald L, Sullivan E, Livadiotis P, Johnson O, Kulak A, Wajcs S, Vose K. Low Risk of Subsequent Deep-Venous Thrombosis in Patients with a Negative Venous Duplex Scan. Clinical And Applied Thrombosis/Hemostasis 1996, 2: 30-34. DOI: 10.1177/107602969600200107.
- Bona R, Sivjee K, Hickey A, Wallace D, Wajcs S. The Efficacy and Safety of Oral Anticoagulation in Patients with Cancer. Thrombosis And Haemostasis 1995, 74: 1055-1058. PMID: 8560413, DOI: 10.1055/s-0038-1649881.
- Rickels F, Hair G, Zelf R, Lee E, Bona R. Tissue Factor Expression in Human Leukocytes and Tumor Cells. Thrombosis And Haemostasis 1995, 74: 391-395. PMID: 8578492, DOI: 10.1055/s-0038-1642709.
- Nulsen J, De Souza M, Walker F, Bona R, Luciano A. Poster Presentation. Menopause The Journal Of The North American Menopause Society 1994, 1: 172. DOI: 10.1097/00042192-199400130-00078.
- Seremetis S, Aledort L, Lau T, Bergman G, Bona R, Rickles F, Bray G, Kessler C, Brettler D, Eyster M, Lusher J. Three-year randomised study of high-purity or intermediate-purity factor VIII concentrates in symptom-free HIV-seropositive haemophiliacs: effects on immune status. The Lancet 1993, 342: 700-703. PMID: 8103820, DOI: 10.1016/0140-6736(93)91706-r.
- Dhami M, Bona R. Thrombosis in patients with cancer. Postgraduate Medicine 1993, 93: 131-140. PMID: 8506172, DOI: 10.1080/00325481.1993.11701721.
- Bona R, Riberio M, Klatsky A, Panek S, Magnifico M, Rickles F. Continuous infusion of porcine factor VIII for the treatment of patients with factor VIII inhibitors. Seminars In Hematology 1993, 30: 32-5. PMID: 8480196.
- Dhami M, Bona R, Calogero J, Hellman R. Venous Thromboembolism and High Grade Gliomas. Thrombosis And Haemostasis 1993, 70: 393-396. PMID: 8259536, DOI: 10.1055/s-0038-1649592.
- Morse E, Panek S, Pisciotto P, Kiraly T, Bona R, Vose K, Rickles F. Reemergence of the International Normalized Ratio for the standardization of prothrombin time. Annals Of Clinical & Laboratory Science 1993, 23: 184-8. PMID: 8323252.
- Parke A, Weinstein R, Bona R, Maier D, Walker F. The thrombotic diathesis associated with the presence of phospholipid antibodies may be due to low levels of free protein S. The American Journal Of Medicine 1992, 93: 49-56. PMID: 1385672, DOI: 10.1016/0002-9343(92)90679-6.
- Clarke B, Ofosu F, Sridhara S, Bona R, Rickles F, Blajchman M. The first epidermal growth factor domain of human coagulation factor VII is essential for binding with tissue factor. FEBS Letters 1992, 298: 206-210. PMID: 1371973, DOI: 10.1016/0014-5793(92)80058-o.
- Dhami M, Bona R. Using anticoagulants safely. Postgraduate Medicine 1991, 90: 121-132. PMID: 1883410, DOI: 10.1080/00325481.1991.11700985.
- Weinstein R, Bona R, Rickles F. Continuous infusion of monoclonal antibody‐purified factor VIII. American Journal Of Hematology 1991, 36: 211-212. PMID: 1899966, DOI: 10.1002/ajh.2830360311.
- Edwards R, Klaus M, Matthews E, McCullen C, Bona R, Rickles F. Heparin abolishes the chemotherapy-induced increase in plasma fibrinopeptide A levels. The American Journal Of Medicine 1990, 89: 25-28. PMID: 2368789, DOI: 10.1016/0002-9343(90)90093-s.
- Weinstein R, Bona R, Altman A, Quinn J, Weisman S, Bartolomeo A, Rickles F. Severe hyponatremia after repeated intravenous administration of desmopressin. American Journal Of Hematology 1989, 32: 258-261. PMID: 2816922, DOI: 10.1002/ajh.2830320405.
- Bona R, Weinstein R, Weisman S, Bartolomeo A, Rickles F. The use of continuous infusion of factor concentrates in the treatment of hemophilia. American Journal Of Hematology 1989, 32: 8-13. PMID: 2502914, DOI: 10.1002/ajh.2830320103.
- Bona R. Von Willebrand factor and von Willebrand's disease: a complex protein and a complex disease. Annals Of Clinical & Laboratory Science 1989, 19: 184-9. PMID: 2499240.
- Bona R, Lee E, Rickles F. Tissue factor apoprotein: Intracellular transport and expression in shed membrane vesicles. Thrombosis Research 1987, 48: 487-500. PMID: 3445230, DOI: 10.1016/0049-3848(87)90405-1.
- Bona R, Pasquale D, Kalish R, Witter B. Porcine factor VIII and plasmapheresis in the management of hemophiliac patients with inhibitors. American Journal Of Hematology 1986, 21: 201-207. PMID: 3079948, DOI: 10.1002/ajh.2830210209.
- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477
Biography
Robert Bona, MD, is a Yale Cancer Center hematologist. He cares for individuals with blood disorders, including those with excessive bleeding or clotting, those with low red blood cell (anemia), low platelet, or white cell counts, and those with disorders of iron metabolism. He is medical director of the Yale Hemophilia Treatment Center.
Dr. Bona says he has been interested in blood disorders since medical school, where he studied with some of the top experts in the field. “I’ve always been interested in looking at blood cells under the microscope and studying blood coagulation and clotting,” he says.
As a Yale Medicine clinician, he often works with teams that include advanced practitioners, nurses, and other specialized physicians from medicine, laboratory medicine, and transfusion medicine, as well as medical providers from related areas such as surgery and radiology.
For those individuals asking for advice or care, he suggests they come to their visit with a sense of what they want to talk about. “Come with an agenda. It might be to discuss your diagnosis, treatment for your disease, or other diagnostic possibilities if the diagnosis has not yet been made,” he says. If you are coming from a medical center with a different medical record system, making your complete medical record available is important to have an optimal visit. It also helps, if you wish, to bring a family member or friend to talk to us about complex medical issues.”
In addition to his clinical work, Dr. Bona is a professor of medicine (hematology) at Yale School of Medicine. He has strong interests in medical education and research interests in new treatments for people with bleeding or clotting disorders. “The education and training of our next generation of physicians and medical educators is very important to me,” he says.
Prior to coming to Yale, Dr. Bona was a founding faculty member of the Frank H. Netter MD School of Medicine at Quinnipiac University. Prior to that, he worked in the Hematology-Oncology division at the University of Connecticut.
Titles
- Professor of Medicine (Hematology)
- Professor of Medicine, Hematology
- Medical Director, Hemophilia Treatment Center
Education & Training
- Non Degree ProgramUniversity of MA, Instructional Design-Certificate (2013)
- Fellow Hematology-OncologyUniversity of Connecticut (1986)
- Intern-ResidentBrown University-Rhode Island Hospital (1983)
- MDSUNY Upstate Medical Center (1980)
Additional Information
- AB of Internal Medicine, Hematology (Internal Medicine) (1986, recertified: 2015)
- AB of Internal Medicine, Medical Oncology (1985)
- AB of Internal Medicine, Internal Medicine (1983)
- Glaeser-Khan S, Ito S, Sra M, Richmond R, Bona R, Krumholz H, Croteau S, Cuker A, Goshua G. Emicizumab for preventing intracranial hemorrhage in infants with severe hemophilia A: a cost-effectiveness analysis. Blood Advances 2025, 9: 6237-6245. PMID: 40795232, PMCID: PMC12744270, DOI: 10.1182/bloodadvances.2025016822.
- Wilson M, Hsia C, Rowan K, Huang S, Ng T, Zypchen L, Bona R, Dehghan N, Chen L. Successful treatment of Kimura disease with Mycophenolate Mofetil: a report of two cases and review of the literature. Rheumatology International 2025, 45: 224. PMID: 40924180, DOI: 10.1007/s00296-025-05985-2.
- Ito S, Potnis K, Harvey J, Sra M, Bewersdorf J, Bona R, Krumholz H, Cuker A, Pandya A, Goshua G. Cost-effectiveness of prophylactic weekly efanesoctocog alfa versus standard-care factor VIII in patients with severe hemophilia A. Annals Of Internal Medicine 2025, 178: 819-828. PMID: 40258278, PMCID: PMC12170149, DOI: 10.7326/annals-24-02749.
- Gu S, Bona R, Hwa J. Technology Spotlight New Dimensions for Platelet Evaluation in Hematology Diagnostics. The Hematologist 2025, 22 DOI: 10.1182/hem.v22.3.202538.
- Gu S, Butt A, Schulz V, Rinder H, Lee A, Gallagher P, Hwa J, Bona R. Phenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies. Blood Cells Molecules And Diseases 2024, 110: 102893. PMID: 39260211, DOI: 10.1016/j.bcmd.2024.102893.
- Waldron C, Ito S, Wang D, Allen C, Viswanathan G, Bona R, Cuker A, Goshua G. Cost-effectiveness of prophylaxis with recombinant vs plasma-derived VWF in severe von Willebrand disease in the United States. Blood 2024, 143: 2332-2335. PMID: 38635764, PMCID: PMC11862817, DOI: 10.1182/blood.2024024209.
- Chiari J, Prozora S, Feinn R, Louizos E, Gallagher P, Bona R. Joint bleeds in mild hemophilia: Prevalence and clinical characteristics. Haemophilia 2024, 30: 331-335. PMID: 38240020, DOI: 10.1111/hae.14939.
- Potnis K, Viswanathan G, Bona R, Ito S, Kempton C, Pandya A, Krumholz H, Goshua G. Cost‐effectiveness of prophylactic emicizumab versus prophylactic recombinant factor VIII in patients with moderate or mild hemophilia A without inhibitors in the United States. American Journal Of Hematology 2023, 98: e247-e250. PMID: 37401660, DOI: 10.1002/ajh.27014.
- Meizlish ML, Goshua G, Liu Y, Fine R, Amin K, Chang E, DeFilippo N, Keating C, Liu Y, Mankbadi M, McManus D, Wang SY, Price C, Bona RD, Chaar C, Chun HJ, Pine AB, Rinder HM, Siner JM, Neuberg DS, Owusu KA, Lee AI. Intermediate‐dose anticoagulation, aspirin, and in‐hospital mortality in COVID‐19: A propensity score‐matched analysis. American Journal Of Hematology 2021, 96: 471-479. PMID: 33476420, PMCID: PMC8013588, DOI: 10.1002/ajh.26102.
- Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/s2352-3026(20)30216-7.
- Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM, Miorin L, Olmo EMD, Alon A, Delaforge E, Hennecker CD, Wang G, Pottel J, Bona R, Smith N, Hall JM, Shapiro G, Clark H, Mittermaier A, Kruse AC, García-Sastre A, Roth BL, Glasspool-Malone J, Francone V, Hertzog N, Fremont-Smith M, Ricke DO. COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms. Research Square 2020 PMID: 32702719, PMCID: PMC7336703, DOI: 10.21203/rs.3.rs-30934/v2.
- Yu E, Feinn R, Bona R, Brink B, Sindhar S, Kozel B, Pober B. Mild macrocytosis in Williams-Beuren syndrome. European Journal Of Medical Genetics 2019, 63: 103740. PMID: 31419598, DOI: 10.1016/j.ejmg.2019.103740.
- Usmani S, Choquette L, Bona R, Feinn R, Shahid Z, Lalla RV. Transient bacteremia induced by dental cleaning is not associated with infection of central venous catheters in patients with cancer. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 2018, 125: 286-294. PMID: 29428697, PMCID: PMC5944361, DOI: 10.1016/j.oooo.2017.12.022.
- Bona R. Hypercoagulable States What the Oral Surgeon Needs to Know. Oral And Maxillofacial Surgery Clinics Of North America 2016, 28: 491-495. PMID: 27745619, DOI: 10.1016/j.coms.2016.06.002.
- Metersky ML, Eldridge N, Wang Y, Jaser L, Bona R, Eckenrode S, Bakullari A, Andrawis M, Classen D, Krumholz HM. Predictors of warfarin‐associated adverse events in hospitalized patients: Opportunities to prevent patient harm. Journal Of Hospital Medicine 2015, 11: 276-282. PMID: 26662851, DOI: 10.1002/jhm.2528.
- Selinger HA, Ballesteros E, Bona R. Concurrent polycythemia vera and chronic lymphocytic leukemia: treatment response to pegylated interferon alpha 2a. American Journal Of Hematology 2013, 88: 535-6. PMID: 23553722, DOI: 10.1002/ajh.23449.
- Bockorny M, Chakravarty S, Schulman P, Bockorny B, Bona R. Severe Heart Failure after Bortezomib Treatment in a Patient with Multiple Myeloma: A Case Report and Review of the Literature. Acta Haematologica 2012, 128: 244-247. PMID: 22964848, DOI: 10.1159/000340050.
- Bona R. ACP Journal Club: review: factor Xa inhibitors reduce DVT more than LMWH in total knee or hip replacement. Annals Of Internal Medicine 2012, 157: jc2-5. PMID: 22910959, DOI: 10.7326/0003-4819-157-4-201208210-02005.
- Linkins L, Dans A, Moores L, Bona R, Davidson B, Schulman S, Crowther M. Treatment and Prevention of Heparin-Induced Thrombocytopenia Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012, 141: e495s-e530s. PMID: 22315270, PMCID: PMC3278058, DOI: 10.1378/chest.11-2303.
- Liu B, Yang Y, Qiu Z, Staron M, Hong F, Li Y, Wu S, Li Y, Hao B, Bona R, Han D, Li Z. Erratum: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nature Communications 2012, 3: 653. PMCID: PMC3464422, DOI: 10.1038/ncomms1398.
- Staron M, Wu S, Hong F, Stojanovic A, Du X, Bona R, Liu B, Li Z. Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex. Blood 2011, 117: 7136-7144. PMID: 21576699, PMCID: PMC3143555, DOI: 10.1182/blood-2011-01-330464.
- Bendel S, Bona R, Baker W. Dabigatran: an oral direct thrombin inhibitor for use in atrial fibrillation. Advances In Therapy 2011, 28: 460. PMID: 21533567, DOI: 10.1007/s12325-011-0025-1.
- Usmani S, Bona R, Chiosis G, Li Z. The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1. Journal Of Hematology & Oncology 2010, 3: 40. PMID: 20977755, PMCID: PMC2974653, DOI: 10.1186/1756-8722-3-40.
- Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperoneLiu B, Yang Y, Qiu Z, Staron M, Hong F, Li Y, Wu S, Li Y, Hao B, Bona R, Han D, Li Z. Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nature Communications 2010, 1: 79. PMID: 20865800, PMCID: PMC2982182, DOI: 10.1038/ncomms1070.
- Odesina V, Bellini S, Leger R, Bona R, Delaney C, Andemariam B, Bacarro N, Lundquist K, Donahoe S, D'Angelo S, Gorenbeyn A, Goodrich S, Tafas C. Evidence‐Based Sickle Cell Pain Management in the Emergency Department. Advanced Emergency Nursing Journal 2010, 32: 102-111. DOI: 10.1097/tme.0b013e3181da588c.
- Roper N, Storer B, Bona R, Fang M. Validation and Comparison of Pharmacogenetics-Based Warfarin Dosing Algorithms for Application of Pharmacogenetic Testing. Journal Of Molecular Diagnostics 2010, 12: 283-291. PMID: 20228265, PMCID: PMC2860463, DOI: 10.2353/jmoldx.2010.090110.
- Usmani S, Bona R, Li Z. 17 AAG for HSP90 inhibition in cancer--from bench to bedside. 2009, 9: 654-64. PMID: 19601813, DOI: 10.2174/156652409788488757.
- Aglieco F, Manickaratnam S, Bona R, Kaplan A. A Case Report of Refractory Warm Autoimmune Hemolytic Anemia Treated With Plasmapheresis and Rituximab. Therapeutic Apheresis And Dialysis 2008, 12: 185-189. PMID: 18387171, DOI: 10.1111/j.1744-9987.2008.00568.x.
- Kapadia P, Bona R. Acquired deficiency of vitamin K-dependent clotting factors due to brodifacoum ingestion. Connecticut Medicine 2008, 72: 207-9. PMID: 18478986.
- Shafique S, Bona R, Kaplan A. A Case Report of Therapeutic Leukapheresis in an Adult With Chronic Myelogenous Leukemia Presenting With Hyperleukocytosis and Leukostasis. Therapeutic Apheresis And Dialysis 2007, 11: 146-149. PMID: 17381536, DOI: 10.1111/j.1744-9987.2007.00417.x.
- Li Z, Qiao Y, Liu B, Laska E, Chakravarthi P, Kulko J, Bona R, Fang M, Hegde U, Moyo V, Tannenbaum S, Ménoret A, Gaffney J, Glynn L, Runowicz C, Srivastava P. Combination of Imatinib Mesylate with Autologous Leukocyte-Derived Heat Shock Protein and Chronic Myelogenous Leukemia. Clinical Cancer Research 2005, 11: 4460-4468. PMID: 15958631, DOI: 10.1158/1078-0432.ccr-05-0250.
- Bona R. Central line thrombosis in patients with cancer. Current Opinion In Pulmonary Medicine 2003, 9: 362-366. PMID: 12904704, DOI: 10.1097/00063198-200309000-00004.
- Tutschka P, Bilgrami S, Feingold J, Edwards R, Bona R, Naqvi B, Clive J. Cytoreduction and Stem Cell Mobilization with a Regimen of Paclitaxel, Etoposide and Cyclophosphamide Followed by Autologous Transplantation Using a Preparative Regimen of Busulfan, Etoposide and Cyclophosphamide for Patients with Advanced Lymphoma. Acta Haematologica 2001, 105: 222-232. PMID: 11528096, DOI: 10.1159/000046569.
- Naqvi B, Dorsky D, Ali S, Feingold J, Edwards R, Bona R, Clive J, Tutschka P, Bilgrami S. Efficacy of Clarithromycin in Preventing Viridans Streptococcal Bacteremia following autologous Stem Cell Transplantation. Infection 2001, 29: 201-204. PMID: 11545480, DOI: 10.1007/s15010-001-1028-7.
- Bilgrami S, Bona R, Edwards R, Li Z, Naqvi B, Shaikh A, Furlong F, Fox J, Clive J, Tutschka P. Dexamethasone, paclitaxel, etoposide, cyclophosphamide (d-TEC) and G-CSF for stem cell mobilisation in multiple myeloma. Bone Marrow Transplantation 2001, 28: 137-143. PMID: 11509931, DOI: 10.1038/sj.bmt.1703126.
- Saif M, Bona R, Greenberg B. AIDS and Thrombosis: Retrospective Study of 131 HIV-Infected Patients. AIDS Patient Care And STDs 2001, 15: 311-320. PMID: 11445013, DOI: 10.1089/108729101750279687.
- Bilgrami S, Metersky M, McNally D, Naqvi B, Kapur D, Raible D, Bona R, Edwards R, Feingold J, Clive J, Tutschka P. Idiopathic Pneumonia Syndrome following Myeloablative Chemotherapy and Autologous Transplantation. Annals Of Pharmacotherapy 2001, 35: 196-201. PMID: 11215840, DOI: 10.1345/aph.10071.
- Bilgrami S, Feingold J, Kapur D, Bona R, Edwards R, Khan A, Rodriguez-Pinero F, Tutschka P. Correspondence: A Novel Combination of Paclitaxel, Etoposide, and Cyclophosphamide for Stem Cell Mobilization and Tumor Cytoreduction in Ovarian Cancer. Stem Cells And Development 2000, 9: 133-135. PMID: 10813526, DOI: 10.1089/152581600319342.
- Bona R, Hickey A, Wallace D. Warfarin Is Safe as Secondary Prophylaxis in Patients With Cancer and a Previous Episode of Venous Thrombosis. American Journal Of Clinical Oncology 2000, 23: 71-73. PMID: 10683083, DOI: 10.1097/00000421-200002000-00020.
- Bilgrami S, Feingold J, Bona R, Edwards R, Khan A, Rodriguez-Pinero F, Khan I, Kazierad D, Clive J, Tutschka P. Dose-intense paclitaxel, etoposide and cyclophosphamide: a safe and active regimen for tumor cytoreduction and stem cell mobilization in metastatic breast cancer. Bone Marrow Transplantation 2000, 25: 123-130. PMID: 10673668, DOI: 10.1038/sj.bmt.1702125.
- Kapur D, Dorsky D, Feingold J, Bona R, Edwards R, Aslanzadeh J, Tutschka P, Bilgrami S. Incidence and outcome of vancomycin-resistant enterococcal bacteremia following autologous peripheral blood stem cell transplantation. Bone Marrow Transplantation 2000, 25: 147-152. PMID: 10673672, DOI: 10.1038/sj.bmt.1702123.
- de Medeiros B, Rezuke W, Ricci A, Tsongalis G, Shen P, Bona R, Feingold J, Edwards R, Tutschka P, Bilgrami S. Kaposi’s Sarcoma following Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia. Acta Haematologica 2000, 104: 115-118. PMID: 11154986, DOI: 10.1159/000039743.
- Bilgrami S, Edwards R, Bona R, Kazierad D, Furlong F, Fox J, Clive J, Naqvi B, Tutschka P. A Pilot Study of Busulfan, Cyclophosphamide and Etoposide Followed by Autologous Transplantation for Acute Myeloid Leukemia in Remission. Acta Haematologica 2000, 104: 144-147. PMID: 11154994, DOI: 10.1159/000039751.
- Bilgrami S, Aslanzadeh J, Feingold J, Bona R, Clive J, Dorsky D, Edwards R, Tutschka P. Cytomegalovirus viremia, viruria and disease after autologous peripheral blood stem cell transplantation: no need for surveillance. Bone Marrow Transplantation 1999, 24: 69-73. PMID: 10435738, DOI: 10.1038/sj.bmt.1701827.
- Bilgrami S, Feingold J, Dorsky D, Edwards R, Bona R, Khan A, Rodriguez-Pinero F, Clive J, Tutschka P. Incidence and outcome of Clostridium difficile infection following autologous peripheral blood stem cell transplantation. Bone Marrow Transplantation 1999, 23: 1039-1042. PMID: 10373070, DOI: 10.1038/sj.bmt.1701773.
- Bona R. Thrombotic Complications of Central Venous Catheters in Cancer Patients. Seminars In Thrombosis And Hemostasis 1999, 25: 147-155. PMID: 10357082, DOI: 10.1055/s-2007-994916.
- Bilgrami S, Chakraborty N, Rodriguez-Pinero F, Khan A, Feingold J, Bona R, Edwards R, Dorsky D, Clive J, Mukherji B, Tutschka P. Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. Bone Marrow Transplantation 1999, 23: 469-474. PMID: 10100561, DOI: 10.1038/sj.bmt.1701594.
- Schindler J, Bona R, Chen H, Feingold J, Edwards R, Tutschka P, Bilgrami S. Regional Thrombolysis with Urokinase for Central Venous Catheter-related Thrombosis in Patients Undergoing High-dose Chemotherapy with Autologous Blood Stem Cell Rescue. Clinical And Applied Thrombosis/Hemostasis 1999, 5: 25-29. PMID: 10725979, DOI: 10.1177/107602969900500106.
- Feingold J, Bilgrami S, Edwards R, Bona R, Tutschka P. #703 High dose mobilization chemotherapy followed by myeloblative therapy with stem cell support for the treatment of small, round, blue cell tumors. Journal Of Pediatric Hematology/Oncology 1998, 20: 412. DOI: 10.1097/00043426-199807000-00140.
- Heit J, Berkowitz S, Bona R, Cabanas V, Corson J, Elliott C, Lyons R. Efficacy and Safety of Low Molecular Weight Heparin (Ardeparin Sodium) Compared to Warfarin for the Prevention of Venous Thromboembolism after Total Knee Replacement Surgery: A Double-blind, Dose-ranging Study. Thrombosis And Haemostasis 1997, 77: 032-038. PMID: 9031445, DOI: 10.1055/s-0038-1655902.
- Bona R, Hickey A, Wallace D. Efficacy and Safety of Oral Anticoagulation in Patients with Cancer. Thrombosis And Haemostasis 1997, 78: 137-140. PMID: 9198143, DOI: 10.1055/s-0038-1657516.
- de Souza M, Nulsen J, Sequenzia L, Bona R, Walker F, Luciano A. The Effect of Medroxyprogesterone Acetate on Conjugated Equine Estrogen-Induced Changes in Coagulation Parameters in Postmenopausal Women. Journal Of Women's Health 1996, 5: 121-128. DOI: 10.1089/jwh.1996.5.121.
- Bona R, Hickey A, Greenwald L, Sullivan E, Livadiotis P, Johnson O, Kulak A, Wajcs S, Vose K. Low Risk of Subsequent Deep-Venous Thrombosis in Patients with a Negative Venous Duplex Scan. Clinical And Applied Thrombosis/Hemostasis 1996, 2: 30-34. DOI: 10.1177/107602969600200107.
- Bona R, Sivjee K, Hickey A, Wallace D, Wajcs S. The Efficacy and Safety of Oral Anticoagulation in Patients with Cancer. Thrombosis And Haemostasis 1995, 74: 1055-1058. PMID: 8560413, DOI: 10.1055/s-0038-1649881.
- Rickels F, Hair G, Zelf R, Lee E, Bona R. Tissue Factor Expression in Human Leukocytes and Tumor Cells. Thrombosis And Haemostasis 1995, 74: 391-395. PMID: 8578492, DOI: 10.1055/s-0038-1642709.
- Nulsen J, De Souza M, Walker F, Bona R, Luciano A. Poster Presentation. Menopause The Journal Of The North American Menopause Society 1994, 1: 172. DOI: 10.1097/00042192-199400130-00078.
- Seremetis S, Aledort L, Lau T, Bergman G, Bona R, Rickles F, Bray G, Kessler C, Brettler D, Eyster M, Lusher J. Three-year randomised study of high-purity or intermediate-purity factor VIII concentrates in symptom-free HIV-seropositive haemophiliacs: effects on immune status. The Lancet 1993, 342: 700-703. PMID: 8103820, DOI: 10.1016/0140-6736(93)91706-r.
- Dhami M, Bona R. Thrombosis in patients with cancer. Postgraduate Medicine 1993, 93: 131-140. PMID: 8506172, DOI: 10.1080/00325481.1993.11701721.
- Bona R, Riberio M, Klatsky A, Panek S, Magnifico M, Rickles F. Continuous infusion of porcine factor VIII for the treatment of patients with factor VIII inhibitors. Seminars In Hematology 1993, 30: 32-5. PMID: 8480196.
- Dhami M, Bona R, Calogero J, Hellman R. Venous Thromboembolism and High Grade Gliomas. Thrombosis And Haemostasis 1993, 70: 393-396. PMID: 8259536, DOI: 10.1055/s-0038-1649592.
- Morse E, Panek S, Pisciotto P, Kiraly T, Bona R, Vose K, Rickles F. Reemergence of the International Normalized Ratio for the standardization of prothrombin time. Annals Of Clinical & Laboratory Science 1993, 23: 184-8. PMID: 8323252.
- Parke A, Weinstein R, Bona R, Maier D, Walker F. The thrombotic diathesis associated with the presence of phospholipid antibodies may be due to low levels of free protein S. The American Journal Of Medicine 1992, 93: 49-56. PMID: 1385672, DOI: 10.1016/0002-9343(92)90679-6.
- Clarke B, Ofosu F, Sridhara S, Bona R, Rickles F, Blajchman M. The first epidermal growth factor domain of human coagulation factor VII is essential for binding with tissue factor. FEBS Letters 1992, 298: 206-210. PMID: 1371973, DOI: 10.1016/0014-5793(92)80058-o.
- Dhami M, Bona R. Using anticoagulants safely. Postgraduate Medicine 1991, 90: 121-132. PMID: 1883410, DOI: 10.1080/00325481.1991.11700985.
- Weinstein R, Bona R, Rickles F. Continuous infusion of monoclonal antibody‐purified factor VIII. American Journal Of Hematology 1991, 36: 211-212. PMID: 1899966, DOI: 10.1002/ajh.2830360311.
- Edwards R, Klaus M, Matthews E, McCullen C, Bona R, Rickles F. Heparin abolishes the chemotherapy-induced increase in plasma fibrinopeptide A levels. The American Journal Of Medicine 1990, 89: 25-28. PMID: 2368789, DOI: 10.1016/0002-9343(90)90093-s.
- Weinstein R, Bona R, Altman A, Quinn J, Weisman S, Bartolomeo A, Rickles F. Severe hyponatremia after repeated intravenous administration of desmopressin. American Journal Of Hematology 1989, 32: 258-261. PMID: 2816922, DOI: 10.1002/ajh.2830320405.
- Bona R, Weinstein R, Weisman S, Bartolomeo A, Rickles F. The use of continuous infusion of factor concentrates in the treatment of hemophilia. American Journal Of Hematology 1989, 32: 8-13. PMID: 2502914, DOI: 10.1002/ajh.2830320103.
- Bona R. Von Willebrand factor and von Willebrand's disease: a complex protein and a complex disease. Annals Of Clinical & Laboratory Science 1989, 19: 184-9. PMID: 2499240.
- Bona R, Lee E, Rickles F. Tissue factor apoprotein: Intracellular transport and expression in shed membrane vesicles. Thrombosis Research 1987, 48: 487-500. PMID: 3445230, DOI: 10.1016/0049-3848(87)90405-1.
- Bona R, Pasquale D, Kalish R, Witter B. Porcine factor VIII and plasmapheresis in the management of hemophiliac patients with inhibitors. American Journal Of Hematology 1986, 21: 201-207. PMID: 3079948, DOI: 10.1002/ajh.2830210209.
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- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477