Smilow Cancer Hospital
Smilow Cancer Hospital at Yale New Haven
35 Park Street
New Haven, CT 06511
- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
Samir Zaidi, MD, PhD
Genitourinary Oncology, Urologic Oncology, Hematology & Oncology
Patient type treated
Adult
Accepting new patients
Yes
Referral required
Not Applicable
Titles
- Assistant Professor of Internal Medicine (Medical Oncology/Hematology)
- Steven Sherwin MD Investigator, Yale Cancer Center
Education & Training
- Medical Oncology FellowMemorial Sloan Kettering Cancer Center (2022)
- ResidentMassachusetts General Hospital, Harvard (2018)
- MDYale School of Medicine (2016)
- PhDYale School of Medicine, Genetics (2015)
- BSMassachusetts Institute of Technology (MIT), Biology (2009)
Additional Information
Honors & Recognitions
- AACR Trailblazer Award: American Association for Cancer Research (AACR) (2026)
- ASCI Physician Scientist Award: The American Society for Clinical Investigation (2026)
- Burroughs Wellcome Fund Career Award for Medical Scientists (CAMS): Burroughs Wellcome Fund (2023)
- Louis V. Gerstner Scholar: Memorial Sloan Kettering Cancer Center (2022)
Publications
- Correia A, Dixon K, Milner J, Parker N, Roth T, Tsai J, Ubellacker J, Vokes N, Zaidi S, Apostolou E, Boire A, Chibwesha C, Merbl Y, Newman A, Tammela T. Insights on Future Directions in Cancer Research from the AACR Trailblazer Cancer Research Grant Awardees. Cancer Discovery 2026, 16: 1730-1738. PMID: 42676103, DOI: 10.1158/2159-8290.cd-26-1356.
- Zaidi S, Kuo P, Prudente T, Lacuna K, Babiker H, Aparicio R, Schonhoft J, Fernandez L, Messmann R, Groaning M, Tolcher A, Gordon M, Yoo D, Vaishampayan U, Picus J, Petrylak D, Sartor O, Morris M. Correlative Biomarker Analysis of PSMA Expression on CTCs and PSMA Imaging in a Phase I Study of PSMA Targeted Tubulysin Conjugate EC1169. Clinical Cancer Research 2026, 32: 1766-1776. PMID: 41591990, PMCID: PMC13034684, DOI: 10.1158/1078-0432.ccr-25-2313.
- Roudier M, Gulati R, Sayar E, Patel R, Tratt M, Richards H, Cejas P, Gomez M, Qiu X, Xie Y, Hanratty B, Zaidi S, Zhao J, Adil M, Mittal C, Zhao Y, Dumpit R, Coleman I, Low J, Persse T, Galipeau P, Lee J, Tretiakova M, Chambers M, Vakar-Lopez F, True L, Perrone M, Lam H, Kollath L, Ding C, Harmon S, Cheng H, Yu E, Montgomery R, Hawley J, Lin D, Corey E, Schweizer M, Setty M, Ha G, Sawyers C, Morrissey C, Long H, Nelson P, Haffner M. Patterns of intra- and inter-tumor phenotypic heterogeneity in lethal prostate cancer. Journal Of Clinical Investigation 2025, 135: e186599. PMID: 40493417, PMCID: PMC12321404, DOI: 10.1172/jci186599.
- Romero R, Chu T, González Robles T, Smith P, Xie Y, Kaur H, Yoder S, Zhao H, Mao C, Kang W, Pulina M, Lawrence K, Gopalan A, Zaidi S, Yoo K, Choi J, Fan N, Gerstner O, Karthaus W, DeStanchina E, Ruggles K, Westcott P, Chaligné R, Pe’er D, Sawyers C. The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1. Nature Cancer 2024, 5: 1641-1659. PMID: 39394434, PMCID: PMC11584404, DOI: 10.1038/s43018-024-00838-6.
- Zaidi S, Park J, Chan J, Roudier M, Zhao J, Gopalan A, Wadosky K, Patel R, Sayar E, Karthaus W, Kates D, Chaudhary O, Xu T, Masilionis I, Mazutis L, Chaligné R, Obradovic A, Linkov I, Barlas A, Jungbluth A, Rekhtman N, Silber J, Manova-Todorova K, Watson P, True L, Morrissey C, Scher H, Rathkopf D, Morris M, Goodrich D, Choi J, Nelson P, Haffner M, Sawyers C. Single-cell analysis of treatment-resistant prostate cancer: Implications of cell state changes for cell surface antigen–targeted therapies. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2322203121. PMID: 38968122, PMCID: PMC11252802, DOI: 10.1073/pnas.2322203121.
- Imberti C, De Gregorio R, Korsen J, Hoang T, Khitrov S, Kalidindi T, Nandakumar S, Park J, Zaidi S, Pillarsetty N, Lewis J. CEACAM5-Targeted Immuno-PET in Androgen Receptor–Negative Prostate Cancer. Journal Of Nuclear Medicine 2024, 65: 1043-1050. PMID: 38782457, PMCID: PMC11218725, DOI: 10.2967/jnumed.123.267107.
- Zaidi M, Zaidi S, Yuen T. Understanding osteokine biology. Cell Metabolism 2024, 36: 888-890. PMID: 38718755, PMCID: PMC11705590, DOI: 10.1016/j.cmet.2024.04.008.
- Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus W, Zaidi S, Zhan Y, Manoj P, Sridhar H, Shah N, Chow A, Bhanot U, Linkov I, Asher M, Yu H, Qiu J, de Stanchina E, Patel R, Morrissey C, Haffner M, Koche R, Sawyers C, Rudin C. Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers. Science Translational Medicine 2023, 15: eadf7006-eadf7006. PMID: 37531417, PMCID: PMC10777207, DOI: 10.1126/scitranslmed.adf7006.
- Chan J, Zaidi S, Love J, Zhao J, Setty M, Wadosky K, Gopalan A, Choo Z, Persad S, Chaudhary O, Xu T, Masilionis I, Morris M, Mazutis L, Chaligne R, Chen Y, Goodrich D, Karthaus W, Pe’er D, Sawyers C. 5 Oral Lineage plasticity in prostate cancer depends on FGFR and JAK/STAT inflammatory signaling. European Journal Of Cancer 2022, 174: s4-s5. DOI: 10.1016/s0959-8049(22)00818-8.
- Chan J, Zaidi S, Love J, Zhao J, Setty M, Wadosky K, Gopalan A, Choo Z, Persad S, Choi J, LaClair J, Lawrence K, Chaudhary O, Xu T, Masilionis I, Linkov I, Wang S, Lee C, Barlas A, Morris M, Mazutis L, Chaligne R, Chen Y, Goodrich D, Karthaus W, Pe’er D, Sawyers C. Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling. Science 2022, 377: 1180-1191. PMID: 35981096, PMCID: PMC9653178, DOI: 10.1126/science.abn0478.
- Miyahira A, Zarif J, Coombs C, Flavell R, Russo J, Zaidi S, Zhao D, Zhao S, Pienta K, Soule H. Prostate cancer research in the 21st century; report from the 2021 Coffey‐Holden prostate cancer academy meeting. The Prostate 2021, 82: 169-181. PMID: 34734426, PMCID: PMC8688282, DOI: 10.1002/pros.24262.
- Robson A, Makova SZ, Barish S, Zaidi S, Mehta S, Drozd J, Jin SC, Gelb BD, Seidman CE, Chung WK, Lifton RP, Khokha MK, Brueckner M. Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 14049-14054. PMID: 31235600, PMCID: PMC6628794, DOI: 10.1073/pnas.1808341116.
- Iqbal J, Yuen T, Zaidi N, Kim S, Zaidi S, Zallone A, Zaidi M, Sun L, Haider S. Chapter 20 Drug Repurposing by Connectivity Mapping and Structural Modeling. 2019, 609-623. DOI: 10.1016/b978-0-12-816125-8.00020-1.
- Gupta AR, Westphal A, Yang DYJ, Sullivan CAW, Eilbott J, Zaidi S, Voos A, Vander Wyk BC, Ventola P, Waqar Z, Fernandez TV, Ercan-Sencicek AG, Walker MF, Choi M, Schneider A, Hedderly T, Baird G, Friedman H, Cordeaux C, Ristow A, Shic F, Volkmar FR, Pelphrey KA. Neurogenetic analysis of childhood disintegrative disorder. Molecular Autism 2017, 8: 19. PMID: 28392909, PMCID: PMC5379515, DOI: 10.1186/s13229-017-0133-0.
- Zaidi S, Brueckner M. Genetics and Genomics of Congenital Heart Disease. Circulation Research 2017, 120: 923-940. PMID: 28302740, PMCID: PMC5557504, DOI: 10.1161/circresaha.116.309140.
- Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. American Journal Of Human Genetics 2016, 99: 1000. PMID: 27716515, PMCID: PMC5065682, DOI: 10.1016/j.ajhg.2016.09.003.
- McKean DM, Homsy J, Wakimoto H, Patel N, Gorham J, DePalma SR, Ware JS, Zaidi S, Ma W, Patel N, Lifton RP, Chung WK, Kim R, Shen Y, Brueckner M, Goldmuntz E, Sharp AJ, Seidman CE, Gelb BD, Seidman JG. Loss of RNA expression and allele-specific expression associated with congenital heart disease. Nature Communications 2016, 7: 12824. PMID: 27670201, PMCID: PMC5052634, DOI: 10.1038/ncomms12824.
- Timberlake AT, Choi J, Zaidi S, Lu Q, Nelson-Williams C, Brooks ED, Bilguvar K, Tikhonova I, Mane S, Yang JF, Sawh-Martinez R, Persing S, Zellner EG, Loring E, Chuang C, Galm A, Hashim PW, Steinbacher DM, DiLuna ML, Duncan CC, Pelphrey KA, Zhao H, Persing JA, Lifton RP. Two locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles. ELife 2016, 5: e20125. PMID: 27606499, PMCID: PMC5045293, DOI: 10.7554/elife.20125.
- Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. American Journal Of Human Genetics 2016, 98: 1082-1091. PMID: 27181681, PMCID: PMC4908195, DOI: 10.1016/j.ajhg.2016.03.022.
- Liu P, Ping Y, Ma M, Zhang D, Liu C, Zaidi S, Gao S, Ji Y, Lou F, Yu F, Lu P, Stachnik A, Bai M, Wei C, Zhang L, Wang K, Chen R, New M, Rowe D, Yuen T, Sun L, Zaidi M. Anabolic actions of Notch on mature bone. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e2152-e2161. PMID: 27036007, PMCID: PMC4839423, DOI: 10.1073/pnas.1603399113.
- Stuart BD, Choi J, Zaidi S, Xing C, Holohan B, Chen R, Choi M, Dharwadkar P, Torres F, Girod CE, Weissler J, Fitzgerald J, Kershaw C, Klesney-Tait J, Mageto Y, Shay JW, Ji W, Bilguvar K, Mane S, Lifton RP, Garcia CK. Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening. Nature Genetics 2015, 47: 512-517. PMID: 25848748, PMCID: PMC4414891, DOI: 10.1038/ng.3278.
- Choate KA, Lu Y, Zhou J, Elias PM, Zaidi S, Paller AS, Farhi A, Nelson-Williams C, Crumrine D, Milstone LM, Lifton RP. Frequent somatic reversion of KRT1 mutations in ichthyosis with confetti. Journal Of Clinical Investigation 2015, 125: 1703-1707. PMID: 25774499, PMCID: PMC4396494, DOI: 10.1172/jci64415.
- Yuan S, Zaidi S, Brueckner M. Congenital heart disease: emerging themes linking genetics and development. Current Opinion In Genetics & Development 2013, 23: 352-359. PMID: 23790954, PMCID: PMC4154700, DOI: 10.1016/j.gde.2013.05.004.
- Zaidi S, Choi M, Wakimoto H, Ma L, Jiang J, Overton JD, Romano-Adesman A, Bjornson RD, Breitbart RE, Brown KK, Carriero NJ, Cheung YH, Deanfield J, DePalma S, Fakhro KA, Glessner J, Hakonarson H, Italia MJ, Kaltman JR, Kaski J, Kim R, Kline JK, Lee T, Leipzig J, Lopez A, Mane SM, Mitchell LE, Newburger JW, Parfenov M, Pe’er I, Porter G, Roberts AE, Sachidanandam R, Sanders SJ, Seiden HS, State MW, Subramanian S, Tikhonova IR, Wang W, Warburton D, White PS, Williams IA, Zhao H, Seidman JG, Brueckner M, Chung WK, Gelb BD, Goldmuntz E, Seidman CE, Lifton RP. De novo mutations in histone-modifying genes in congenital heart disease. Nature 2013, 498: 220-223. PMID: 23665959, PMCID: PMC3706629, DOI: 10.1038/nature12141.
- Zaidi S, Zhu L, Mali R, Iqbal J, Yang G, Zaidi M, Sun L. Regulation of FSH receptor promoter activation in the osteoclast. Biochemical And Biophysical Research Communications 2007, 361: 910-915. PMID: 17681281, DOI: 10.1016/j.bbrc.2007.07.081.
- Zhu L, Zaidi S, Peng Y, Zhou H, Moonga B, Blesius A, Dupin-Roger I, Zaidi M, Sun L. Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Biochemical And Biophysical Research Communications 2007, 355: 307-311. PMID: 17300752, DOI: 10.1016/j.bbrc.2007.01.120.
- Sun L, Peng Y, Sharrow A, Iqbal J, Zhang Z, Papachristou D, Zaidi S, Zhu L, Yaroslavskiy B, Zhou H, Zallone A, Sairam M, Kumar T, Bo W, Braun J, Cardoso-Landa L, Schaffler M, Moonga B, Blair H, Zaidi M. FSH Directly Regulates Bone Mass. Cell 2006, 125: 247-260. PMID: 16630814, DOI: 10.1016/j.cell.2006.01.051.
- Sun L, Iqbal J, Zaidi S, Zhu L, Zhang X, Peng Y, Moonga B, Zaidi M. Structure and functional regulation of the CD38 promoter. Biochemical And Biophysical Research Communications 2006, 341: 804-809. PMID: 16442077, DOI: 10.1016/j.bbrc.2006.01.033.
- Zhu L, Zaidi S, Moonga B, Troen B, Sun L. RANK-L induces the expression of NFATc1, but not of NFκB subunits during osteoclast formation. Biochemical And Biophysical Research Communications 2004, 326: 131-135. PMID: 15567162, DOI: 10.1016/j.bbrc.2004.10.212.
Locations
Smilow Cancer Hospital
Smilow Cancer Hospital at Yale New Haven
35 Park Street
New Haven, CT 06511
- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
Titles
- Assistant Professor of Internal Medicine (Medical Oncology/Hematology)
- Steven Sherwin MD Investigator, Yale Cancer Center
Education & Training
- Medical Oncology FellowMemorial Sloan Kettering Cancer Center (2022)
- ResidentMassachusetts General Hospital, Harvard (2018)
- MDYale School of Medicine (2016)
- PhDYale School of Medicine, Genetics (2015)
- BSMassachusetts Institute of Technology (MIT), Biology (2009)
Additional Information
Honors & Recognitions
- AACR Trailblazer Award: American Association for Cancer Research (AACR) (2026)
- ASCI Physician Scientist Award: The American Society for Clinical Investigation (2026)
- Burroughs Wellcome Fund Career Award for Medical Scientists (CAMS): Burroughs Wellcome Fund (2023)
- Louis V. Gerstner Scholar: Memorial Sloan Kettering Cancer Center (2022)
Publications
- Correia A, Dixon K, Milner J, Parker N, Roth T, Tsai J, Ubellacker J, Vokes N, Zaidi S, Apostolou E, Boire A, Chibwesha C, Merbl Y, Newman A, Tammela T. Insights on Future Directions in Cancer Research from the AACR Trailblazer Cancer Research Grant Awardees. Cancer Discovery 2026, 16: 1730-1738. PMID: 42676103, DOI: 10.1158/2159-8290.cd-26-1356.
- Zaidi S, Kuo P, Prudente T, Lacuna K, Babiker H, Aparicio R, Schonhoft J, Fernandez L, Messmann R, Groaning M, Tolcher A, Gordon M, Yoo D, Vaishampayan U, Picus J, Petrylak D, Sartor O, Morris M. Correlative Biomarker Analysis of PSMA Expression on CTCs and PSMA Imaging in a Phase I Study of PSMA Targeted Tubulysin Conjugate EC1169. Clinical Cancer Research 2026, 32: 1766-1776. PMID: 41591990, PMCID: PMC13034684, DOI: 10.1158/1078-0432.ccr-25-2313.
- Roudier M, Gulati R, Sayar E, Patel R, Tratt M, Richards H, Cejas P, Gomez M, Qiu X, Xie Y, Hanratty B, Zaidi S, Zhao J, Adil M, Mittal C, Zhao Y, Dumpit R, Coleman I, Low J, Persse T, Galipeau P, Lee J, Tretiakova M, Chambers M, Vakar-Lopez F, True L, Perrone M, Lam H, Kollath L, Ding C, Harmon S, Cheng H, Yu E, Montgomery R, Hawley J, Lin D, Corey E, Schweizer M, Setty M, Ha G, Sawyers C, Morrissey C, Long H, Nelson P, Haffner M. Patterns of intra- and inter-tumor phenotypic heterogeneity in lethal prostate cancer. Journal Of Clinical Investigation 2025, 135: e186599. PMID: 40493417, PMCID: PMC12321404, DOI: 10.1172/jci186599.
- Romero R, Chu T, González Robles T, Smith P, Xie Y, Kaur H, Yoder S, Zhao H, Mao C, Kang W, Pulina M, Lawrence K, Gopalan A, Zaidi S, Yoo K, Choi J, Fan N, Gerstner O, Karthaus W, DeStanchina E, Ruggles K, Westcott P, Chaligné R, Pe’er D, Sawyers C. The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1. Nature Cancer 2024, 5: 1641-1659. PMID: 39394434, PMCID: PMC11584404, DOI: 10.1038/s43018-024-00838-6.
- Zaidi S, Park J, Chan J, Roudier M, Zhao J, Gopalan A, Wadosky K, Patel R, Sayar E, Karthaus W, Kates D, Chaudhary O, Xu T, Masilionis I, Mazutis L, Chaligné R, Obradovic A, Linkov I, Barlas A, Jungbluth A, Rekhtman N, Silber J, Manova-Todorova K, Watson P, True L, Morrissey C, Scher H, Rathkopf D, Morris M, Goodrich D, Choi J, Nelson P, Haffner M, Sawyers C. Single-cell analysis of treatment-resistant prostate cancer: Implications of cell state changes for cell surface antigen–targeted therapies. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2322203121. PMID: 38968122, PMCID: PMC11252802, DOI: 10.1073/pnas.2322203121.
- Imberti C, De Gregorio R, Korsen J, Hoang T, Khitrov S, Kalidindi T, Nandakumar S, Park J, Zaidi S, Pillarsetty N, Lewis J. CEACAM5-Targeted Immuno-PET in Androgen Receptor–Negative Prostate Cancer. Journal Of Nuclear Medicine 2024, 65: 1043-1050. PMID: 38782457, PMCID: PMC11218725, DOI: 10.2967/jnumed.123.267107.
- Zaidi M, Zaidi S, Yuen T. Understanding osteokine biology. Cell Metabolism 2024, 36: 888-890. PMID: 38718755, PMCID: PMC11705590, DOI: 10.1016/j.cmet.2024.04.008.
- Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus W, Zaidi S, Zhan Y, Manoj P, Sridhar H, Shah N, Chow A, Bhanot U, Linkov I, Asher M, Yu H, Qiu J, de Stanchina E, Patel R, Morrissey C, Haffner M, Koche R, Sawyers C, Rudin C. Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers. Science Translational Medicine 2023, 15: eadf7006-eadf7006. PMID: 37531417, PMCID: PMC10777207, DOI: 10.1126/scitranslmed.adf7006.
- Chan J, Zaidi S, Love J, Zhao J, Setty M, Wadosky K, Gopalan A, Choo Z, Persad S, Chaudhary O, Xu T, Masilionis I, Morris M, Mazutis L, Chaligne R, Chen Y, Goodrich D, Karthaus W, Pe’er D, Sawyers C. 5 Oral Lineage plasticity in prostate cancer depends on FGFR and JAK/STAT inflammatory signaling. European Journal Of Cancer 2022, 174: s4-s5. DOI: 10.1016/s0959-8049(22)00818-8.
- Chan J, Zaidi S, Love J, Zhao J, Setty M, Wadosky K, Gopalan A, Choo Z, Persad S, Choi J, LaClair J, Lawrence K, Chaudhary O, Xu T, Masilionis I, Linkov I, Wang S, Lee C, Barlas A, Morris M, Mazutis L, Chaligne R, Chen Y, Goodrich D, Karthaus W, Pe’er D, Sawyers C. Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling. Science 2022, 377: 1180-1191. PMID: 35981096, PMCID: PMC9653178, DOI: 10.1126/science.abn0478.
- Miyahira A, Zarif J, Coombs C, Flavell R, Russo J, Zaidi S, Zhao D, Zhao S, Pienta K, Soule H. Prostate cancer research in the 21st century; report from the 2021 Coffey‐Holden prostate cancer academy meeting. The Prostate 2021, 82: 169-181. PMID: 34734426, PMCID: PMC8688282, DOI: 10.1002/pros.24262.
- Robson A, Makova SZ, Barish S, Zaidi S, Mehta S, Drozd J, Jin SC, Gelb BD, Seidman CE, Chung WK, Lifton RP, Khokha MK, Brueckner M. Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 14049-14054. PMID: 31235600, PMCID: PMC6628794, DOI: 10.1073/pnas.1808341116.
- Iqbal J, Yuen T, Zaidi N, Kim S, Zaidi S, Zallone A, Zaidi M, Sun L, Haider S. Chapter 20 Drug Repurposing by Connectivity Mapping and Structural Modeling. 2019, 609-623. DOI: 10.1016/b978-0-12-816125-8.00020-1.
- Gupta AR, Westphal A, Yang DYJ, Sullivan CAW, Eilbott J, Zaidi S, Voos A, Vander Wyk BC, Ventola P, Waqar Z, Fernandez TV, Ercan-Sencicek AG, Walker MF, Choi M, Schneider A, Hedderly T, Baird G, Friedman H, Cordeaux C, Ristow A, Shic F, Volkmar FR, Pelphrey KA. Neurogenetic analysis of childhood disintegrative disorder. Molecular Autism 2017, 8: 19. PMID: 28392909, PMCID: PMC5379515, DOI: 10.1186/s13229-017-0133-0.
- Zaidi S, Brueckner M. Genetics and Genomics of Congenital Heart Disease. Circulation Research 2017, 120: 923-940. PMID: 28302740, PMCID: PMC5557504, DOI: 10.1161/circresaha.116.309140.
- Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. American Journal Of Human Genetics 2016, 99: 1000. PMID: 27716515, PMCID: PMC5065682, DOI: 10.1016/j.ajhg.2016.09.003.
- McKean DM, Homsy J, Wakimoto H, Patel N, Gorham J, DePalma SR, Ware JS, Zaidi S, Ma W, Patel N, Lifton RP, Chung WK, Kim R, Shen Y, Brueckner M, Goldmuntz E, Sharp AJ, Seidman CE, Gelb BD, Seidman JG. Loss of RNA expression and allele-specific expression associated with congenital heart disease. Nature Communications 2016, 7: 12824. PMID: 27670201, PMCID: PMC5052634, DOI: 10.1038/ncomms12824.
- Timberlake AT, Choi J, Zaidi S, Lu Q, Nelson-Williams C, Brooks ED, Bilguvar K, Tikhonova I, Mane S, Yang JF, Sawh-Martinez R, Persing S, Zellner EG, Loring E, Chuang C, Galm A, Hashim PW, Steinbacher DM, DiLuna ML, Duncan CC, Pelphrey KA, Zhao H, Persing JA, Lifton RP. Two locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles. ELife 2016, 5: e20125. PMID: 27606499, PMCID: PMC5045293, DOI: 10.7554/elife.20125.
- Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. American Journal Of Human Genetics 2016, 98: 1082-1091. PMID: 27181681, PMCID: PMC4908195, DOI: 10.1016/j.ajhg.2016.03.022.
- Liu P, Ping Y, Ma M, Zhang D, Liu C, Zaidi S, Gao S, Ji Y, Lou F, Yu F, Lu P, Stachnik A, Bai M, Wei C, Zhang L, Wang K, Chen R, New M, Rowe D, Yuen T, Sun L, Zaidi M. Anabolic actions of Notch on mature bone. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e2152-e2161. PMID: 27036007, PMCID: PMC4839423, DOI: 10.1073/pnas.1603399113.
- Stuart BD, Choi J, Zaidi S, Xing C, Holohan B, Chen R, Choi M, Dharwadkar P, Torres F, Girod CE, Weissler J, Fitzgerald J, Kershaw C, Klesney-Tait J, Mageto Y, Shay JW, Ji W, Bilguvar K, Mane S, Lifton RP, Garcia CK. Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening. Nature Genetics 2015, 47: 512-517. PMID: 25848748, PMCID: PMC4414891, DOI: 10.1038/ng.3278.
- Choate KA, Lu Y, Zhou J, Elias PM, Zaidi S, Paller AS, Farhi A, Nelson-Williams C, Crumrine D, Milstone LM, Lifton RP. Frequent somatic reversion of KRT1 mutations in ichthyosis with confetti. Journal Of Clinical Investigation 2015, 125: 1703-1707. PMID: 25774499, PMCID: PMC4396494, DOI: 10.1172/jci64415.
- Yuan S, Zaidi S, Brueckner M. Congenital heart disease: emerging themes linking genetics and development. Current Opinion In Genetics & Development 2013, 23: 352-359. PMID: 23790954, PMCID: PMC4154700, DOI: 10.1016/j.gde.2013.05.004.
- Zaidi S, Choi M, Wakimoto H, Ma L, Jiang J, Overton JD, Romano-Adesman A, Bjornson RD, Breitbart RE, Brown KK, Carriero NJ, Cheung YH, Deanfield J, DePalma S, Fakhro KA, Glessner J, Hakonarson H, Italia MJ, Kaltman JR, Kaski J, Kim R, Kline JK, Lee T, Leipzig J, Lopez A, Mane SM, Mitchell LE, Newburger JW, Parfenov M, Pe’er I, Porter G, Roberts AE, Sachidanandam R, Sanders SJ, Seiden HS, State MW, Subramanian S, Tikhonova IR, Wang W, Warburton D, White PS, Williams IA, Zhao H, Seidman JG, Brueckner M, Chung WK, Gelb BD, Goldmuntz E, Seidman CE, Lifton RP. De novo mutations in histone-modifying genes in congenital heart disease. Nature 2013, 498: 220-223. PMID: 23665959, PMCID: PMC3706629, DOI: 10.1038/nature12141.
- Zaidi S, Zhu L, Mali R, Iqbal J, Yang G, Zaidi M, Sun L. Regulation of FSH receptor promoter activation in the osteoclast. Biochemical And Biophysical Research Communications 2007, 361: 910-915. PMID: 17681281, DOI: 10.1016/j.bbrc.2007.07.081.
- Zhu L, Zaidi S, Peng Y, Zhou H, Moonga B, Blesius A, Dupin-Roger I, Zaidi M, Sun L. Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Biochemical And Biophysical Research Communications 2007, 355: 307-311. PMID: 17300752, DOI: 10.1016/j.bbrc.2007.01.120.
- Sun L, Peng Y, Sharrow A, Iqbal J, Zhang Z, Papachristou D, Zaidi S, Zhu L, Yaroslavskiy B, Zhou H, Zallone A, Sairam M, Kumar T, Bo W, Braun J, Cardoso-Landa L, Schaffler M, Moonga B, Blair H, Zaidi M. FSH Directly Regulates Bone Mass. Cell 2006, 125: 247-260. PMID: 16630814, DOI: 10.1016/j.cell.2006.01.051.
- Sun L, Iqbal J, Zaidi S, Zhu L, Zhang X, Peng Y, Moonga B, Zaidi M. Structure and functional regulation of the CD38 promoter. Biochemical And Biophysical Research Communications 2006, 341: 804-809. PMID: 16442077, DOI: 10.1016/j.bbrc.2006.01.033.
- Zhu L, Zaidi S, Moonga B, Troen B, Sun L. RANK-L induces the expression of NFATc1, but not of NFκB subunits during osteoclast formation. Biochemical And Biophysical Research Communications 2004, 326: 131-135. PMID: 15567162, DOI: 10.1016/j.bbrc.2004.10.212.
Locations
Smilow Cancer Hospital
Smilow Cancer Hospital at Yale New Haven
35 Park Street
New Haven, CT 06511
- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
Smilow Cancer Hospital
Smilow Cancer Hospital at Yale New Haven
35 Park Street
New Haven, CT 06511
- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511