- Yale Gynecologic OncologySmilow Cancer Hospital Care Center - Waterford230 Waterford Parkway SouthWaterford, CT 06385
- Yale Gynecologic OncologyStamford Hospital1 Hospital PlazaStamford, CT 06902
Mitchell Clark, MD
Biography
Mitchell Clark, MD, is a gynecologic oncologist with training in both surgical and medical oncology. He has expertise in chemotherapy, targeted therapies, and minimally invasive surgeries. He sees women with gynecologic malignancies and complex surgical problems, as well as genetic conditions that put them at risk for developing a gynecologic cancer.
Dr. Clark grew up in a small, rural community, where he began thinking about becoming a doctor after a close family member died from ovarian cancer. “I saw the lack of resources and advanced treatment options, and limitations in the system,” he says. “I was inspired to pursue a specialty where I could advocate for women to receive the highest quality of care close to home.”
Since then he’s seen improvements in both treatments and survival rates for women with gynecologic cancers. Surgery has evolved to the point where he can usually offer a minimally invasive approach that not only treats cancer, but also allows patients to return to their normal routines “faster than ever,” he says. “Being at Yale allows me to offer comprehensive cancer care that encompasses a multidisciplinary approach spanning from early detection to survivorship.”
In addition to caring for patients, Dr. Clark is interested in improving care for his patients through research. “I am passionate about leveraging the power of large health care administrative databases that include thousands of women to try and answer the important questions facing our specialty,” he says. Another interest is early detection and prevention of cervical cancer. “We know that most cervical cancers are due to human papillomavirus [HPV] infections, which can be prevented through vaccination,” Dr. Clark says.
Titles
- Assistant Professor of Obstetrics, Gynecology & Reproductive Sciences
- Director, Gynecologic Oncology at Waterford
- Assistant Program Director, Minimally Invasive Gynecological Surgery Program
- Member, Center for Precision Diagnosis of Trophoblastic Disease
Education & Training
- FellowUniversity of Toronto (2020)
- ResidentYale University Bridgeport Hospital (2017)
- BScSt. Francis Xavier University, Biology (2009)
- MDAUC School of Medicine
Languages Spoken
- English
- Français (French)
Additional Information
- Early Career Investigator: NRG Oncology (2021)
- Best Oral Presentation, Annual Research Day: Department of Obstetrics and Gynecology, University of Toronto (2019)
- Best Poster Presentation, Annual General Meeting: The Society of Gynecologic Oncology of Canada (2018)
- Award for Excellence in Female Pelvic Medicine and Reconstructive Surgery: American Urogynecologic Society (2017)
- Excellence in Minimally Invasive Gynecology in Residency: American Association of of Gynecologic Laparoscopists (2017)
- Medical Student Educator of the Year: Yale University School of Medicine (2017)
- Travel and Education Grant: Society of Laparoendoscopic Surgeons (2016)
- Medical Student Educator of the Year: Yale School of Medicine (2015)
- Dr. Asudulla-Bibijan Award for Excellence in Undergraduate Research: St. Francis Xavier University (2009)
- Young Researcher Award: Canadian Breast Cancer Foundation (2007)
- Royal College of Physicians & Surgeons of CANADA, Obstetrics & Gynecology (2018)
- Yale New Haven Healthy Lawrence and Memorial Hospital (2023 - Present): Physician Advisory Council
- Frontiers in Oncology (2023 - Present): Editor
- Connecticut Department of Health (2023 - Present): CT Cancer Partnership's HPV workgroup
- Insider (2022 - Present): https://www.insider.com/uterine-cancer-researchers-obgyn-want-more-data-on-hair-straightener-chemicals-2022-12
- Department of OBGYN Diversity, Equity and Inclusion, Research and Recruitment (2022 - Present): Co-Chair
- Yale University School of Medicine (2022 - Present): Medical Education Committee
- Medical Education Committee (2022 - Present): Member
- Diversity, Equity and Inclusion Committee of the Society of Gynecologic Oncology (2021 - Present): Committee Member
- Society of Gynecologic Oncologists of Canada (2017 - Present): Member
- American Association of Gynecologic Laparoscopists (2014 - Present): Member
- Harold J, Bellone S, Manavell D, Mutlu L, McNamara B, Hartwich T, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa M, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang G, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz P, Santin A. Corrigendum to “Elimusertib (BAY1895344), a novel ATR inhibitor, demonstrates in vivo activity in ATRX mutated models of uterine leiomyosarcoma” Gynecologic Oncology 2023, 170: 334. PMID: 36906375, DOI: 10.1016/j.ygyno.2023.01.029.
- Sullivan M, Michel L, Wasser T, Clark M, Chudnoff S, Andikyan V. Changes to same day discharge after minimally invasive hysterectomy throughout COVID‐19 pandemic Journal Of Obstetrics And Gynaecology Research 2023 PMID: 36808793, DOI: 10.1111/jog.15617.
- Han C, McNamara B, Bellone S, Harold J, Manara P, Hartwich T, Mutlu L, Yang-Hartwich Y, Zipponi M, Demirkiran C, Verzosa M, Altwerger G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Dottino P, Schwartz P, Santin A. The Poly (ADP-ribose) polymerase inhibitor olaparib and pan-ErbB inhibitor neratinib are highly synergistic in HER2 overexpressing epithelial ovarian carcinoma in vitro and in vivo Gynecologic Oncology 2023, 170: 172-178. PMID: 36706643, PMCID: PMC10023457, DOI: 10.1016/j.ygyno.2023.01.015.
- Mauricio D, Bellone S, Mutlu L, McNamara B, Manavella D, Demirkiran C, Verzosa M, Buza N, Hui P, Hartwich T, Harold J, Yang-Hartwich Y, Zipponi M, Altwerger G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Santin A. Trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody–drug conjugate with topoisomerase I inhibitor payload, shows antitumor activity in uterine and ovarian carcinosarcoma with HER2/neu expression Gynecologic Oncology 2023, 170: 38-45. PMID: 36610380, DOI: 10.1016/j.ygyno.2022.12.018.
- Manavella D, McNamara B, Harold J, Bellone S, Hartwich T, Yang-Hartwich Y, Mutlu L, Zipponi M, Demirkiran C, Verzosa M, Altwerger G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Dottino P, Choi J, Alexandrov L, Buza N, Hui P, Santin A. Ovarian and uterine carcinosarcomas are sensitive in vitro and in vivo to elimusertib, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor Gynecologic Oncology 2022, 169: 98-105. PMID: 36525930, PMCID: PMC9925406, DOI: 10.1016/j.ygyno.2022.12.003.
- Harold J, Manavella D, Bellone S, Siegel E, Hartwich T, Zammataro L, Mutlu L, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Alexandrov L, Santin A. EP007/#994 Bay 1895344, a novel ATR inhibitor, demonstrates in vivo activity against ATRX altered uterine leiomyosarcoma 2022, a51.1-a51. DOI: 10.1136/ijgc-2022-igcs.98.
- Piedimonte S, Kim R, Bernardini M, Atenafu E, Clark M, Lheureux S, May T. Validation of the KELIM score as a predictor of response to neoadjuvant treatment in patients with advanced high grade serous ovarian cancer Gynecologic Oncology 2022, 167: 417-422. DOI: 10.1016/j.ygyno.2022.10.014.
- Harold J, Bellone S, Manavella D, Mutlu L, McNamara B, Hartwich T, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa M, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang G, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz P, Santin A. Elimusertib (BAY1895344), a novel ATR inhibitor, demonstrates in vivo activity in ATRX mutated models of uterine leiomyosarcoma Gynecologic Oncology 2022, 168: 157-165. PMID: 36442427, PMCID: PMC9797429, DOI: 10.1016/j.ygyno.2022.11.014.
- Harold J, Manavella D, Bellone S, Siegel E, Mauricio D, Hartwich T, Zammataro L, Mutlu L, AlAshqar A, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Alexandrov L, Santin A. BAY1895344, a novel ataxia telangiectasia and RAD3-related (ATR) inhibitor, is active in vivo against ATRX mutated uterine leiomyosarcoma (212) Gynecologic Oncology 2022, 166: s118. DOI: 10.1016/s0090-8258(22)01437-8.
- Mauricio D, Bellone S, Manavella D, Harold J, Buza N, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Santin A. Trastuzumab deruxtecan (DS-8201a), a HER2-Targeting Antibody-Drug Conjugate with Topoisomerase I Inhibitor Payload, Shows Antitumor Activity in Uterine and Ovarian Carcinosarcoma with HER2/neu Expression (046) Gynecologic Oncology 2022, 166: s31-s32. DOI: 10.1016/s0090-8258(22)01265-3.
- Manavella D, Harold J, Bellone S, Hartwich T, Mutlu L, Tymon-Rosario J, Siegel E, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Alexandrov L, Santin A. Ovarian and uterine carcinosarcoma cell lines show preclinical sensitivity to BAY 1895344, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor (011) Gynecologic Oncology 2022, 166: s9. DOI: 10.1016/s0090-8258(22)01229-x.
- Tymon-Rosario J, Manara P, Manavella D, Bellone S, Siegel E, Hartwich T, Harold J, Zammataro L, Yang-Hartwich Y, Mutlu L, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Alexandrov L, Santin A. Homologous recombination deficiency (HRD) signature-3 in ovarian and uterine carcinosarcomas correlates with preclinical sensitivity to Olaparib, a Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor (043) Gynecologic Oncology 2022, 166: s30. DOI: 10.1016/s0090-8258(22)01262-8.
- Mutlu L, Manavella D, Bellone S, Harold J, Mauricio D, Tymon-Rosario J, Siegel E, Hartwich T, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Santin A. In Vivo and In Vitro Efficacy of Enhertu in Uterine Serous Carcinoma (047) Gynecologic Oncology 2022, 166: s32-s33. DOI: 10.1016/s0090-8258(22)01266-5.
- Piedimonte S, Kim S, Clark M, Lheureux S, May T, Bernardini M, Atenafu E. The modeled CA-125 elimination rate constant k (KELIM) score as a predictor of treatment response in patients with advanced high grade serous ovarian cancer (190) Gynecologic Oncology 2022, 166: s109. DOI: 10.1016/s0090-8258(22)01417-2.
- Bellone S, Roque DM, Siegel ER, Buza N, Hui P, Bonazzoli E, Guglielmi A, Zammataro L, Nagarkatti N, Zaidi S, Lee J, Silasi D, Huang GS, Andikyan V, Damast S, Clark M, Azodi M, Schwartz PE, Tymon‐Rosario J, Harold JA, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Alexandrov LB, Iwasaki A, Kong Y, Song E, Dong W, Elvin JA, Choi J, Santin AD. A phase 2 evaluation of pembrolizumab for recurrent Lynch‐like versus sporadic endometrial cancers with microsatellite instability Cancer 2021, 128: 1206-1218. PMID: 34875107, PMCID: PMC9465822, DOI: 10.1002/cncr.34025.
- Clark M, Tchrakian N, Clarke B, Metser U, Bouchard-Fortier G. Placenta increta mimicking placental site trophoblastic tumor. International Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society 2021, 31: 1481-1485. PMID: 34725244, DOI: 10.1136/ijgc-2021-002988.
- Mauricio D, Webster E, Harold J, Altwerger G, Azodi M, Clark M, Huang G, Menderes G, Ratner E, Santin A, Schwartz P, Andikyan V. Two-Port Robotic Laparoscopic Hysterectomy Journal Of Minimally Invasive Gynecology 2021, 28: s155. DOI: 10.1016/j.jmig.2021.09.315.
- Roque D, Siegel E, Buza N, Bellone S, Silasi D, Huang G, Andikyan V, Clark M, Azodi M, Schwartz P, Rao G, Reader J, Hui P, Tymon-Rosario J, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Santin A. Randomized phase II trial of weekly ixabepilone with or without biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer Gynecologic Oncology 2021, 162: s58. DOI: 10.1016/s0090-8258(21)00753-8.
- Webster E, Arkfeld C, Chang Y, Yadav G, Zeybek B, Tymon-Rosario J, Harold J, Clark M, Andikyan V, Huang G, Menderes G, Azodi M, Santin A, Schwartz P, Ratner E, Altwerger G. Charlson Comorbidity Index as a predictor of postoperative complication in octogenarians and nonagenarians with stage I endometrioid endometrial cancer: a single-institution retrospective review Gynecologic Oncology 2021, 162: s108. DOI: 10.1016/s0090-8258(21)00848-9.
- Zeybek B, Webster E, Pogosian N, Tymon-Rosario J, Mauricio D, Harold J, Menderes G, Altwerger G, Malette J, Luther M, Baker L, Balch A, Clark M, Huang G, Azodi M, Ratner E, Schwartz P, Santin A, Andikyan V. Financial toxicity in patients with gynecologic malignancies Gynecologic Oncology 2021, 162: s162. DOI: 10.1016/s0090-8258(21)00950-1.
- Tymon-Rosario J, Bonazzoli E, Guglielmi A, Bellone S, Nagarkatti N, Zammataro L, Zeybek B, Harold J, Mauricio D, Clark M, Andikyan V, Huang G, Altwerger G, Menderes G, Azodi M, Ratner E, Schwartz P, Santin A. In vitro and in vivo activity of DHES0815A, an antibody-drug conjugate targeting HER2/neu in uterine serous carcinoma Gynecologic Oncology 2021, 162: s186-s187. DOI: 10.1016/s0090-8258(21)01001-5.
- Clark M, Jembere N, Kupets R. The impact of a universal human papilloma virus (HPV) vaccination program on lower genital tract dysplasia and genital warts Preventive Medicine 2021, 150: 106641. PMID: 34048822, DOI: 10.1016/j.ypmed.2021.106641.
- Choi J, Manzano A, Dong W, Bellone S, Bonazzoli E, Zammataro L, Yao X, Deshpande A, Zaidi S, Guglielmi A, Gnutti B, Nagarkatti N, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Jeong K, Zhao S, Buza N, Hui P, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Ardighieri L, Bilguvar K, Quick CM, Silasi DA, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Imielinski M, Schwartz PE, Alexandrov LB, Lifton RP, Schlessinger J, Santin AD. Integrated mutational landscape analysis of uterine leiomyosarcomas Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2025182118. PMID: 33876771, PMCID: PMC8053980, DOI: 10.1073/pnas.2025182118.
- Clark M, Jembere N, Wang L, Kupets R. Survival of Older Women With Cervical Cancer Based on Screening History. Journal Of Lower Genital Tract Disease 2021, 25: 9-14. PMID: 33347044, DOI: 10.1097/lgt.0000000000000582.
- The impact of a universal HPV vaccination program on lower genital tract dysplasia and genital wartsClark M, Jembere N, Kupets R. The impact of a universal HPV vaccination program on lower genital tract dysplasia and genital warts Gynecologic Oncology 2020, 159: 173. DOI: 10.1016/j.ygyno.2020.05.257.
- Clark M, Kollara A, May T, Brown T. Resuming chemotherapy after interval cytoreductive surgery in ovarian cancer: The impact of time and temperature Gynecologic Oncology 2019, 154: 55-56. DOI: 10.1016/j.ygyno.2019.04.133.
- Clark M, houssan L, Liu Z, Bernardini M. Is there a benefit to the lowest possible CA-125: The relationship between biomarkers and survival in epithelial ovarian cancer Gynecologic Oncology 2019, 154: 261. DOI: 10.1016/j.ygyno.2019.04.603.
- Clark M, Lee A, Kupets R. Limitations in Correspondence Programs for Cervical Cancer Screening: Who Are the Women We Are Missing? Journal Of Obstetrics And Gynaecology Canada 2019, 41: 1410-1415. PMID: 30803876, DOI: 10.1016/j.jogc.2018.11.034.
- Seifi F, Parkash V, Clark M, Menderes G, Tierney C, Silasi DA, Azodi M. Pseudovascular Invasion: Minimally Invasive Surgery for Endometrial Cancer JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 2019, 23: e2019.00021. PMID: 31285650, PMCID: PMC6596444, DOI: 10.4293/jsls.2019.00021.
- Seifi F, Clark M, Menderes G, Silasi D, Azodi M. 500 Does Use of Manipulator for Endometrial Cancer Surgery Lead to Increased Use of Adjuvant Therapy? Journal Of Minimally Invasive Gynecology 2018, 25: s175. DOI: 10.1016/j.jmig.2018.09.512.
- Clark M, Seifi F, Parkash V, Silasi D, Azodi M. Does the use of manipulator for endometrial cancer surgery lead to increased use of adjuvant therapy? Gynecologic Oncology 2018, 149: 93. DOI: 10.1016/j.ygyno.2018.04.213.
- Cancer screening correspondence coverage in Ontario, Canada: Factors related to limitations in reachClark M, Lee A, Kupets R. Cancer screening correspondence coverage in Ontario, Canada: Factors related to limitations in reach Gynecologic Oncology 2018, 149: 126-127. DOI: 10.1016/j.ygyno.2018.04.292.
- Lennox G, Clark M, Zigras T, Rouzbahman M, Han G, Bernardini M, Gien L. Clinical stage II endometrial cancer: Is there a benefit to radical hysterectomy? Gynecologic Oncology 2018, 149: 103. DOI: 10.1016/j.ygyno.2018.04.239.
- Lee Y, Lee J, Paik E, Clark M, Kim R, Brown T, May T. Investigating the time intervals between primary cytoreductive surgery and initiation of adjuvant chemotherapy in patients with advanced epithelial ovarian cancer who had optimal cytoreduction surgery with bowel resection Gynecologic Oncology 2018, 149: 98. DOI: 10.1016/j.ygyno.2018.04.226.
- Clark M, Lee Y, Xu W, Brown T, May T. Does the time interval off neoadjuvant chemotherapy before and after interval debulking surgery affect the overall survival of women with advanced-epithelial ovarian cancer? Gynecologic Oncology 2018, 149: 92. DOI: 10.1016/j.ygyno.2018.04.210.
- Seifi F, Clark M, Sami A, Azodi M. 519 Recurrent Endometrial Cancer : Robotic-Assisted Laparoscopy, Debulking of Tumor with Dense Adhesion to Iliac Vessels, Involving Upper Vagina and Ureterovesical Junction Journal Of Minimally Invasive Gynecology 2017, 24: s183. DOI: 10.1016/j.jmig.2017.08.547.
- Seifi F, Davis M, Clark M, Paraiso E, Azodi M. 563 Robatic Tumor Debulking with Partial Cystectomy, Bladder Reconstruction, and Ureteral Implantation in Recurrent Endometrial Cancer Journal Of Minimally Invasive Gynecology 2017, 24: s184-s185. DOI: 10.1016/j.jmig.2017.08.591.
- Cocco E, Deng Y, Shapiro EM, Bortolomai I, Lopez S, Lin K, Bellone S, Cui J, Menderes G, Black JD, Schwab CL, Bonazzoli E, Yang F, Predolini F, Zammataro L, Altwerger G, de Haydu C, Clark M, Alvarenga J, Ratner E, Azodi M, Silasi DA, Schwartz PE, Litkouhi B, Saltzman WM, Santin AD. Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells Molecular Cancer Therapeutics 2017, 16: 323-333. PMID: 27956521, PMCID: PMC5292071, DOI: 10.1158/1535-7163.mct-16-0501.
- Clark M, Menderes G, Azodi M, Finberg K, Canosa S, Parkash V. Endometrial carcinoma as the presenting malignancy in an 18-year-old patient with Li-Fraumeni syndrome Gynecologic Oncology 2016, 141: 183-184. DOI: 10.1016/j.ygyno.2016.04.473.
- Menderes G, Clark M, Santin AD. Novel targeted therapies in uterine serous carcinoma, an aggressive variant of endometrial cancer. Discovery Medicine 2016, 21: 293-303. PMID: 27232515.
- Clark M, Glasgow M, Menderes G, Azodi M, Silasi D. Uterine Serous Carcinoma: Does surgical approach impact survival? Gynecologic Oncology 2015, 139: 592. DOI: 10.1016/j.ygyno.2015.09.045.
- Clark M, Glasgow M, Menderes G, Azodi M, Silasi DA. Early Stage Uterine Serous Carcinoma: Does Surgical Approach Impact Survival? Journal Of Minimally Invasive Gynecology 2015, 22: s48-s49. PMID: 27679256, DOI: 10.1016/j.jmig.2015.08.134.
- Clark Donat L, Tower A, Clark M, Silasi DA, Azodi M. Identifying Risk Factors for Urinar y Retention After Hysterectomy for Leiomyoma Journal Of Minimally Invasive Gynecology 2015, 22: s59. PMID: 27679285, DOI: 10.1016/j.jmig.2015.08.157.
- Minimally Invasive Non-Laparoscopic Ovarian Cystectomy: A Unique Way to Approach Large Ovarian CystsClark M, Zigras T, Bayat L, Kashani S. Minimally Invasive Non-Laparoscopic Ovarian Cystectomy: A Unique Way to Approach Large Ovarian Cysts Journal Of Minimally Invasive Gynecology 2015, 22: s150. PMID: 27678844, DOI: 10.1016/j.jmig.2015.08.547.
- Donat L, Clark M, Tower AM, Menderes G, Parkash V, Silasi DA, Azodi M. Transvaginal Morcellation JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 2015, 19: e2014.00255. PMID: 26005318, PMCID: PMC4432719, DOI: 10.4293/jsls.2014.00255.
- O’Sullivan R, Sauer C, Friedman P, Clark M, Menderes G. Rupture of the Unscarred Gravid Uterus: Case Series Journal Of Medical Cases 2015, 6: 330-332. DOI: 10.14740/jmc2203w.
- Clark L, Clark M, Menderes G, Silasi D, Azodi M. Risk Factors Associated with Urinary Retention after Robotic-Assisted Laparoscopic Hysterectomy Journal Of Minimally Invasive Gynecology 2014, 21: s205. DOI: 10.1016/j.jmig.2014.08.658.
Biography
Mitchell Clark, MD, is a gynecologic oncologist with training in both surgical and medical oncology. He has expertise in chemotherapy, targeted therapies, and minimally invasive surgeries. He sees women with gynecologic malignancies and complex surgical problems, as well as genetic conditions that put them at risk for developing a gynecologic cancer.
Dr. Clark grew up in a small, rural community, where he began thinking about becoming a doctor after a close family member died from ovarian cancer. “I saw the lack of resources and advanced treatment options, and limitations in the system,” he says. “I was inspired to pursue a specialty where I could advocate for women to receive the highest quality of care close to home.”
Since then he’s seen improvements in both treatments and survival rates for women with gynecologic cancers. Surgery has evolved to the point where he can usually offer a minimally invasive approach that not only treats cancer, but also allows patients to return to their normal routines “faster than ever,” he says. “Being at Yale allows me to offer comprehensive cancer care that encompasses a multidisciplinary approach spanning from early detection to survivorship.”
In addition to caring for patients, Dr. Clark is interested in improving care for his patients through research. “I am passionate about leveraging the power of large health care administrative databases that include thousands of women to try and answer the important questions facing our specialty,” he says. Another interest is early detection and prevention of cervical cancer. “We know that most cervical cancers are due to human papillomavirus [HPV] infections, which can be prevented through vaccination,” Dr. Clark says.
Titles
- Assistant Professor of Obstetrics, Gynecology & Reproductive Sciences
- Director, Gynecologic Oncology at Waterford
- Assistant Program Director, Minimally Invasive Gynecological Surgery Program
- Member, Center for Precision Diagnosis of Trophoblastic Disease
Education & Training
- FellowUniversity of Toronto (2020)
- ResidentYale University Bridgeport Hospital (2017)
- BScSt. Francis Xavier University, Biology (2009)
- MDAUC School of Medicine
Languages Spoken
- English
- Français (French)
Additional Information
- Early Career Investigator: NRG Oncology (2021)
- Best Oral Presentation, Annual Research Day: Department of Obstetrics and Gynecology, University of Toronto (2019)
- Best Poster Presentation, Annual General Meeting: The Society of Gynecologic Oncology of Canada (2018)
- Award for Excellence in Female Pelvic Medicine and Reconstructive Surgery: American Urogynecologic Society (2017)
- Excellence in Minimally Invasive Gynecology in Residency: American Association of of Gynecologic Laparoscopists (2017)
- Medical Student Educator of the Year: Yale University School of Medicine (2017)
- Travel and Education Grant: Society of Laparoendoscopic Surgeons (2016)
- Medical Student Educator of the Year: Yale School of Medicine (2015)
- Dr. Asudulla-Bibijan Award for Excellence in Undergraduate Research: St. Francis Xavier University (2009)
- Young Researcher Award: Canadian Breast Cancer Foundation (2007)
- Royal College of Physicians & Surgeons of CANADA, Obstetrics & Gynecology (2018)
- Yale New Haven Healthy Lawrence and Memorial Hospital (2023 - Present): Physician Advisory Council
- Frontiers in Oncology (2023 - Present): Editor
- Connecticut Department of Health (2023 - Present): CT Cancer Partnership's HPV workgroup
- Insider (2022 - Present): https://www.insider.com/uterine-cancer-researchers-obgyn-want-more-data-on-hair-straightener-chemicals-2022-12
- Department of OBGYN Diversity, Equity and Inclusion, Research and Recruitment (2022 - Present): Co-Chair
- Yale University School of Medicine (2022 - Present): Medical Education Committee
- Medical Education Committee (2022 - Present): Member
- Diversity, Equity and Inclusion Committee of the Society of Gynecologic Oncology (2021 - Present): Committee Member
- Society of Gynecologic Oncologists of Canada (2017 - Present): Member
- American Association of Gynecologic Laparoscopists (2014 - Present): Member
- Harold J, Bellone S, Manavell D, Mutlu L, McNamara B, Hartwich T, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa M, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang G, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz P, Santin A. Corrigendum to “Elimusertib (BAY1895344), a novel ATR inhibitor, demonstrates in vivo activity in ATRX mutated models of uterine leiomyosarcoma” Gynecologic Oncology 2023, 170: 334. PMID: 36906375, DOI: 10.1016/j.ygyno.2023.01.029.
- Sullivan M, Michel L, Wasser T, Clark M, Chudnoff S, Andikyan V. Changes to same day discharge after minimally invasive hysterectomy throughout COVID‐19 pandemic Journal Of Obstetrics And Gynaecology Research 2023 PMID: 36808793, DOI: 10.1111/jog.15617.
- Han C, McNamara B, Bellone S, Harold J, Manara P, Hartwich T, Mutlu L, Yang-Hartwich Y, Zipponi M, Demirkiran C, Verzosa M, Altwerger G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Dottino P, Schwartz P, Santin A. The Poly (ADP-ribose) polymerase inhibitor olaparib and pan-ErbB inhibitor neratinib are highly synergistic in HER2 overexpressing epithelial ovarian carcinoma in vitro and in vivo Gynecologic Oncology 2023, 170: 172-178. PMID: 36706643, PMCID: PMC10023457, DOI: 10.1016/j.ygyno.2023.01.015.
- Mauricio D, Bellone S, Mutlu L, McNamara B, Manavella D, Demirkiran C, Verzosa M, Buza N, Hui P, Hartwich T, Harold J, Yang-Hartwich Y, Zipponi M, Altwerger G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Santin A. Trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody–drug conjugate with topoisomerase I inhibitor payload, shows antitumor activity in uterine and ovarian carcinosarcoma with HER2/neu expression Gynecologic Oncology 2023, 170: 38-45. PMID: 36610380, DOI: 10.1016/j.ygyno.2022.12.018.
- Manavella D, McNamara B, Harold J, Bellone S, Hartwich T, Yang-Hartwich Y, Mutlu L, Zipponi M, Demirkiran C, Verzosa M, Altwerger G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Dottino P, Choi J, Alexandrov L, Buza N, Hui P, Santin A. Ovarian and uterine carcinosarcomas are sensitive in vitro and in vivo to elimusertib, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor Gynecologic Oncology 2022, 169: 98-105. PMID: 36525930, PMCID: PMC9925406, DOI: 10.1016/j.ygyno.2022.12.003.
- Harold J, Manavella D, Bellone S, Siegel E, Hartwich T, Zammataro L, Mutlu L, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Alexandrov L, Santin A. EP007/#994 Bay 1895344, a novel ATR inhibitor, demonstrates in vivo activity against ATRX altered uterine leiomyosarcoma 2022, a51.1-a51. DOI: 10.1136/ijgc-2022-igcs.98.
- Piedimonte S, Kim R, Bernardini M, Atenafu E, Clark M, Lheureux S, May T. Validation of the KELIM score as a predictor of response to neoadjuvant treatment in patients with advanced high grade serous ovarian cancer Gynecologic Oncology 2022, 167: 417-422. DOI: 10.1016/j.ygyno.2022.10.014.
- Harold J, Bellone S, Manavella D, Mutlu L, McNamara B, Hartwich T, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa M, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang G, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz P, Santin A. Elimusertib (BAY1895344), a novel ATR inhibitor, demonstrates in vivo activity in ATRX mutated models of uterine leiomyosarcoma Gynecologic Oncology 2022, 168: 157-165. PMID: 36442427, PMCID: PMC9797429, DOI: 10.1016/j.ygyno.2022.11.014.
- Harold J, Manavella D, Bellone S, Siegel E, Mauricio D, Hartwich T, Zammataro L, Mutlu L, AlAshqar A, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Alexandrov L, Santin A. BAY1895344, a novel ataxia telangiectasia and RAD3-related (ATR) inhibitor, is active in vivo against ATRX mutated uterine leiomyosarcoma (212) Gynecologic Oncology 2022, 166: s118. DOI: 10.1016/s0090-8258(22)01437-8.
- Mauricio D, Bellone S, Manavella D, Harold J, Buza N, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Santin A. Trastuzumab deruxtecan (DS-8201a), a HER2-Targeting Antibody-Drug Conjugate with Topoisomerase I Inhibitor Payload, Shows Antitumor Activity in Uterine and Ovarian Carcinosarcoma with HER2/neu Expression (046) Gynecologic Oncology 2022, 166: s31-s32. DOI: 10.1016/s0090-8258(22)01265-3.
- Manavella D, Harold J, Bellone S, Hartwich T, Mutlu L, Tymon-Rosario J, Siegel E, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Alexandrov L, Santin A. Ovarian and uterine carcinosarcoma cell lines show preclinical sensitivity to BAY 1895344, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor (011) Gynecologic Oncology 2022, 166: s9. DOI: 10.1016/s0090-8258(22)01229-x.
- Tymon-Rosario J, Manara P, Manavella D, Bellone S, Siegel E, Hartwich T, Harold J, Zammataro L, Yang-Hartwich Y, Mutlu L, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Alexandrov L, Santin A. Homologous recombination deficiency (HRD) signature-3 in ovarian and uterine carcinosarcomas correlates with preclinical sensitivity to Olaparib, a Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor (043) Gynecologic Oncology 2022, 166: s30. DOI: 10.1016/s0090-8258(22)01262-8.
- Mutlu L, Manavella D, Bellone S, Harold J, Mauricio D, Tymon-Rosario J, Siegel E, Hartwich T, Altwerger G, Menderes G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Santin A. In Vivo and In Vitro Efficacy of Enhertu in Uterine Serous Carcinoma (047) Gynecologic Oncology 2022, 166: s32-s33. DOI: 10.1016/s0090-8258(22)01266-5.
- Piedimonte S, Kim S, Clark M, Lheureux S, May T, Bernardini M, Atenafu E. The modeled CA-125 elimination rate constant k (KELIM) score as a predictor of treatment response in patients with advanced high grade serous ovarian cancer (190) Gynecologic Oncology 2022, 166: s109. DOI: 10.1016/s0090-8258(22)01417-2.
- Bellone S, Roque DM, Siegel ER, Buza N, Hui P, Bonazzoli E, Guglielmi A, Zammataro L, Nagarkatti N, Zaidi S, Lee J, Silasi D, Huang GS, Andikyan V, Damast S, Clark M, Azodi M, Schwartz PE, Tymon‐Rosario J, Harold JA, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Alexandrov LB, Iwasaki A, Kong Y, Song E, Dong W, Elvin JA, Choi J, Santin AD. A phase 2 evaluation of pembrolizumab for recurrent Lynch‐like versus sporadic endometrial cancers with microsatellite instability Cancer 2021, 128: 1206-1218. PMID: 34875107, PMCID: PMC9465822, DOI: 10.1002/cncr.34025.
- Clark M, Tchrakian N, Clarke B, Metser U, Bouchard-Fortier G. Placenta increta mimicking placental site trophoblastic tumor. International Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society 2021, 31: 1481-1485. PMID: 34725244, DOI: 10.1136/ijgc-2021-002988.
- Mauricio D, Webster E, Harold J, Altwerger G, Azodi M, Clark M, Huang G, Menderes G, Ratner E, Santin A, Schwartz P, Andikyan V. Two-Port Robotic Laparoscopic Hysterectomy Journal Of Minimally Invasive Gynecology 2021, 28: s155. DOI: 10.1016/j.jmig.2021.09.315.
- Roque D, Siegel E, Buza N, Bellone S, Silasi D, Huang G, Andikyan V, Clark M, Azodi M, Schwartz P, Rao G, Reader J, Hui P, Tymon-Rosario J, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Santin A. Randomized phase II trial of weekly ixabepilone with or without biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer Gynecologic Oncology 2021, 162: s58. DOI: 10.1016/s0090-8258(21)00753-8.
- Webster E, Arkfeld C, Chang Y, Yadav G, Zeybek B, Tymon-Rosario J, Harold J, Clark M, Andikyan V, Huang G, Menderes G, Azodi M, Santin A, Schwartz P, Ratner E, Altwerger G. Charlson Comorbidity Index as a predictor of postoperative complication in octogenarians and nonagenarians with stage I endometrioid endometrial cancer: a single-institution retrospective review Gynecologic Oncology 2021, 162: s108. DOI: 10.1016/s0090-8258(21)00848-9.
- Zeybek B, Webster E, Pogosian N, Tymon-Rosario J, Mauricio D, Harold J, Menderes G, Altwerger G, Malette J, Luther M, Baker L, Balch A, Clark M, Huang G, Azodi M, Ratner E, Schwartz P, Santin A, Andikyan V. Financial toxicity in patients with gynecologic malignancies Gynecologic Oncology 2021, 162: s162. DOI: 10.1016/s0090-8258(21)00950-1.
- Tymon-Rosario J, Bonazzoli E, Guglielmi A, Bellone S, Nagarkatti N, Zammataro L, Zeybek B, Harold J, Mauricio D, Clark M, Andikyan V, Huang G, Altwerger G, Menderes G, Azodi M, Ratner E, Schwartz P, Santin A. In vitro and in vivo activity of DHES0815A, an antibody-drug conjugate targeting HER2/neu in uterine serous carcinoma Gynecologic Oncology 2021, 162: s186-s187. DOI: 10.1016/s0090-8258(21)01001-5.
- Clark M, Jembere N, Kupets R. The impact of a universal human papilloma virus (HPV) vaccination program on lower genital tract dysplasia and genital warts Preventive Medicine 2021, 150: 106641. PMID: 34048822, DOI: 10.1016/j.ypmed.2021.106641.
- Choi J, Manzano A, Dong W, Bellone S, Bonazzoli E, Zammataro L, Yao X, Deshpande A, Zaidi S, Guglielmi A, Gnutti B, Nagarkatti N, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Jeong K, Zhao S, Buza N, Hui P, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Ardighieri L, Bilguvar K, Quick CM, Silasi DA, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Imielinski M, Schwartz PE, Alexandrov LB, Lifton RP, Schlessinger J, Santin AD. Integrated mutational landscape analysis of uterine leiomyosarcomas Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2025182118. PMID: 33876771, PMCID: PMC8053980, DOI: 10.1073/pnas.2025182118.
- Clark M, Jembere N, Wang L, Kupets R. Survival of Older Women With Cervical Cancer Based on Screening History. Journal Of Lower Genital Tract Disease 2021, 25: 9-14. PMID: 33347044, DOI: 10.1097/lgt.0000000000000582.
- The impact of a universal HPV vaccination program on lower genital tract dysplasia and genital wartsClark M, Jembere N, Kupets R. The impact of a universal HPV vaccination program on lower genital tract dysplasia and genital warts Gynecologic Oncology 2020, 159: 173. DOI: 10.1016/j.ygyno.2020.05.257.
- Clark M, Kollara A, May T, Brown T. Resuming chemotherapy after interval cytoreductive surgery in ovarian cancer: The impact of time and temperature Gynecologic Oncology 2019, 154: 55-56. DOI: 10.1016/j.ygyno.2019.04.133.
- Clark M, houssan L, Liu Z, Bernardini M. Is there a benefit to the lowest possible CA-125: The relationship between biomarkers and survival in epithelial ovarian cancer Gynecologic Oncology 2019, 154: 261. DOI: 10.1016/j.ygyno.2019.04.603.
- Clark M, Lee A, Kupets R. Limitations in Correspondence Programs for Cervical Cancer Screening: Who Are the Women We Are Missing? Journal Of Obstetrics And Gynaecology Canada 2019, 41: 1410-1415. PMID: 30803876, DOI: 10.1016/j.jogc.2018.11.034.
- Seifi F, Parkash V, Clark M, Menderes G, Tierney C, Silasi DA, Azodi M. Pseudovascular Invasion: Minimally Invasive Surgery for Endometrial Cancer JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 2019, 23: e2019.00021. PMID: 31285650, PMCID: PMC6596444, DOI: 10.4293/jsls.2019.00021.
- Seifi F, Clark M, Menderes G, Silasi D, Azodi M. 500 Does Use of Manipulator for Endometrial Cancer Surgery Lead to Increased Use of Adjuvant Therapy? Journal Of Minimally Invasive Gynecology 2018, 25: s175. DOI: 10.1016/j.jmig.2018.09.512.
- Clark M, Seifi F, Parkash V, Silasi D, Azodi M. Does the use of manipulator for endometrial cancer surgery lead to increased use of adjuvant therapy? Gynecologic Oncology 2018, 149: 93. DOI: 10.1016/j.ygyno.2018.04.213.
- Cancer screening correspondence coverage in Ontario, Canada: Factors related to limitations in reachClark M, Lee A, Kupets R. Cancer screening correspondence coverage in Ontario, Canada: Factors related to limitations in reach Gynecologic Oncology 2018, 149: 126-127. DOI: 10.1016/j.ygyno.2018.04.292.
- Lennox G, Clark M, Zigras T, Rouzbahman M, Han G, Bernardini M, Gien L. Clinical stage II endometrial cancer: Is there a benefit to radical hysterectomy? Gynecologic Oncology 2018, 149: 103. DOI: 10.1016/j.ygyno.2018.04.239.
- Lee Y, Lee J, Paik E, Clark M, Kim R, Brown T, May T. Investigating the time intervals between primary cytoreductive surgery and initiation of adjuvant chemotherapy in patients with advanced epithelial ovarian cancer who had optimal cytoreduction surgery with bowel resection Gynecologic Oncology 2018, 149: 98. DOI: 10.1016/j.ygyno.2018.04.226.
- Clark M, Lee Y, Xu W, Brown T, May T. Does the time interval off neoadjuvant chemotherapy before and after interval debulking surgery affect the overall survival of women with advanced-epithelial ovarian cancer? Gynecologic Oncology 2018, 149: 92. DOI: 10.1016/j.ygyno.2018.04.210.
- Seifi F, Clark M, Sami A, Azodi M. 519 Recurrent Endometrial Cancer : Robotic-Assisted Laparoscopy, Debulking of Tumor with Dense Adhesion to Iliac Vessels, Involving Upper Vagina and Ureterovesical Junction Journal Of Minimally Invasive Gynecology 2017, 24: s183. DOI: 10.1016/j.jmig.2017.08.547.
- Seifi F, Davis M, Clark M, Paraiso E, Azodi M. 563 Robatic Tumor Debulking with Partial Cystectomy, Bladder Reconstruction, and Ureteral Implantation in Recurrent Endometrial Cancer Journal Of Minimally Invasive Gynecology 2017, 24: s184-s185. DOI: 10.1016/j.jmig.2017.08.591.
- Cocco E, Deng Y, Shapiro EM, Bortolomai I, Lopez S, Lin K, Bellone S, Cui J, Menderes G, Black JD, Schwab CL, Bonazzoli E, Yang F, Predolini F, Zammataro L, Altwerger G, de Haydu C, Clark M, Alvarenga J, Ratner E, Azodi M, Silasi DA, Schwartz PE, Litkouhi B, Saltzman WM, Santin AD. Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells Molecular Cancer Therapeutics 2017, 16: 323-333. PMID: 27956521, PMCID: PMC5292071, DOI: 10.1158/1535-7163.mct-16-0501.
- Clark M, Menderes G, Azodi M, Finberg K, Canosa S, Parkash V. Endometrial carcinoma as the presenting malignancy in an 18-year-old patient with Li-Fraumeni syndrome Gynecologic Oncology 2016, 141: 183-184. DOI: 10.1016/j.ygyno.2016.04.473.
- Menderes G, Clark M, Santin AD. Novel targeted therapies in uterine serous carcinoma, an aggressive variant of endometrial cancer. Discovery Medicine 2016, 21: 293-303. PMID: 27232515.
- Clark M, Glasgow M, Menderes G, Azodi M, Silasi D. Uterine Serous Carcinoma: Does surgical approach impact survival? Gynecologic Oncology 2015, 139: 592. DOI: 10.1016/j.ygyno.2015.09.045.
- Clark M, Glasgow M, Menderes G, Azodi M, Silasi DA. Early Stage Uterine Serous Carcinoma: Does Surgical Approach Impact Survival? Journal Of Minimally Invasive Gynecology 2015, 22: s48-s49. PMID: 27679256, DOI: 10.1016/j.jmig.2015.08.134.
- Clark Donat L, Tower A, Clark M, Silasi DA, Azodi M. Identifying Risk Factors for Urinar y Retention After Hysterectomy for Leiomyoma Journal Of Minimally Invasive Gynecology 2015, 22: s59. PMID: 27679285, DOI: 10.1016/j.jmig.2015.08.157.
- Minimally Invasive Non-Laparoscopic Ovarian Cystectomy: A Unique Way to Approach Large Ovarian CystsClark M, Zigras T, Bayat L, Kashani S. Minimally Invasive Non-Laparoscopic Ovarian Cystectomy: A Unique Way to Approach Large Ovarian Cysts Journal Of Minimally Invasive Gynecology 2015, 22: s150. PMID: 27678844, DOI: 10.1016/j.jmig.2015.08.547.
- Donat L, Clark M, Tower AM, Menderes G, Parkash V, Silasi DA, Azodi M. Transvaginal Morcellation JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 2015, 19: e2014.00255. PMID: 26005318, PMCID: PMC4432719, DOI: 10.4293/jsls.2014.00255.
- O’Sullivan R, Sauer C, Friedman P, Clark M, Menderes G. Rupture of the Unscarred Gravid Uterus: Case Series Journal Of Medical Cases 2015, 6: 330-332. DOI: 10.14740/jmc2203w.
- Clark L, Clark M, Menderes G, Silasi D, Azodi M. Risk Factors Associated with Urinary Retention after Robotic-Assisted Laparoscopic Hysterectomy Journal Of Minimally Invasive Gynecology 2014, 21: s205. DOI: 10.1016/j.jmig.2014.08.658.
- Yale Gynecologic OncologySmilow Cancer Hospital Care Center - Waterford230 Waterford Parkway SouthWaterford, CT 06385
- Yale Gynecologic OncologyStamford Hospital1 Hospital PlazaStamford, CT 06902