Michael Chiorazzi, MD, PhD
Medical Oncology, Head & Neck Cancers
Titles
- Assistant Professor of Internal Medicine (Medical Oncology)
Education & Training
- Post-Doctoral Fellow, ImmunobiologyYale School of Medicine (2019)
- Fellow, ABIM Research Pathway, Hematology & Medical OncologyYale School of Medicine (2018)
- Resident, ABIM Research Pathway, Internal MedicineYale School of Medicine (2014)
- PhDThe Rockefeller University (2012)
- MDCornell University Medical College (2012)
- BAWilliams College, Biology (2002)
Additional Information
Board Certifications
- AB of Internal Medicine, Medical Oncology (2022)
- AB of Internal Medicine, Internal Medicine (2016)
Publications
- Chiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins K, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze L, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Goedegebuure S, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Kluger Y, Palucka K, Fields R, Flavell R. Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment. Journal For ImmunoTherapy Of Cancer 2023, 11: e006921. PMID: 37487666, PMCID: PMC10373695, DOI: 10.1136/jitc-2023-006921.
- Tyagi T, Jain K, Yarovinsky TO, Chiorazzi M, Du J, Castro C, Griffin J, Korde A, Martin KA, Takyar SS, Flavell RA, Patel AA, Hwa J. Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells. Journal Of Experimental Medicine 2022, 220: e20212218. PMID: 36305874, PMCID: PMC9814191, DOI: 10.1084/jem.20212218.
- Martinek J, Lin J, Kim KI, Wang VG, Wu TC, Chiorazzi M, Boruchov H, Gulati A, Seeniraj S, Sun L, Marches F, Robson P, Rongvaux A, Flavell RA, George J, Chuang JH, Banchereau J, Palucka K. Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function. Cell Reports Medicine 2022, 3: 100621. PMID: 35584631, PMCID: PMC9133468, DOI: 10.1016/j.xcrm.2022.100621.
- Martinek J, Kim K, Lin J, Wu T, Borouchov H, Gulati A, Sun L, Wang V, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract 3441: Transcriptional profiles of CD14+ cells in situ in melanoma reveal plasticity, localization dependent function and specific T cell interactions. Cancer Research 2020, 80: 3441-3441. DOI: 10.1158/1538-7445.am2020-3441.
- Martinek J, in Kim K, Wu T, Boruchov H, Gulati A, Sun L, Wang V, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract A103: Transcriptional profiles of CD14+ cells in situ in melanoma reveal plasticity, localization-dependent function, and specific T-cell interactions. Cancer Immunology Research 2020, 8: a103-a103. DOI: 10.1158/2326-6074.tumimm19-a103.
- Martinek J, Kim K, Wu T, Wang V, Brookes H, Sun L, Gulati A, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract 1507: Transcriptional profiles of CD14+ cells in situ in melanoma tumors reveal plasticity and localization dependent function. 2019, 1507-1507. DOI: 10.1158/1538-7445.sabcs18-1507.
- Martinek J, Kim K, Wu T, Wang V, Brookes H, Sun L, Gulati A, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract 1507: Transcriptional profiles of CD14+ cells in situ in melanoma tumors reveal plasticity and localization dependent function. Cancer Research 2019, 79: 1507-1507. DOI: 10.1158/1538-7445.am2019-1507.
- Bailis W, Shyer JA, Chiorazzi M, Flavell RA. No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs. Cancer Cell 2017, 32: 280-281. PMID: 28898693, PMCID: PMC6939383, DOI: 10.1016/j.ccell.2017.08.013.
- Chiorazzi M, Rui L, Yang Y, Ceribelli M, Tishbi N, Maurer CW, Ranuncolo SM, Zhao H, Xu W, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Shaham S, Staudt LM. Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3943-3948. PMID: 23431138, PMCID: PMC3593917, DOI: 10.1073/pnas.1217271110.
- Hystad M, Myklebust J, Bø T, Sivertsen E, Rian E, Forfang L, Munthe E, Rosenwald A, Chiorazzi M, Jonassen I, Staudt L, Smeland E. Characterization of early stages of human B cell development by gene expression profiling. The Journal Of Immunology 2009, 182: 5882-5882. DOI: 10.4049/jimmunol.0990031.
- Hystad ME, Myklebust JH, Bø TH, Sivertsen EA, Rian E, Forfang L, Munthe E, Rosenwald A, Chiorazzi M, Jonassen I, Staudt LM, Smeland EB. Characterization of Early Stages of Human B Cell Development by Gene Expression Profiling. The Journal Of Immunology 2007, 179: 3662-3671. PMID: 17785802, DOI: 10.4049/jimmunol.179.6.3662.
- Maurer CW, Chiorazzi M, Shaham S. Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene. Development 2007, 134: 1357-1368. PMID: 17329362, DOI: 10.1242/dev.02818.
- Wiestner A, Tehrani M, Chiorazzi M, Wright G, Gibellini F, Nakayama K, Liu H, Rosenwald A, Muller-Hermelink HK, Ott G, Chan WC, Greiner TC, Weisenburger DD, Vose J, Armitage JO, Gascoyne RD, Connors JM, Campo E, Montserrat E, Bosch F, Smeland EB, Kvaloy S, Holte H, Delabie J, Fisher RI, Grogan TM, Miller TP, Wilson WH, Jaffe ES, Staudt LM. Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival. Blood 2007, 109: 4599-4606. PMID: 17299095, PMCID: PMC1885523, DOI: 10.1182/blood-2006-08-039859.
- Hystad M, Bo T, Rian E, Myklebust J, Sivertsen E, Forfang L, Chiorazzi M, Rosenwald A, Jonassen I, Staudt L, Smeland E. Characterization of Early Human B Cell Development by Gene Expression Profiling. Blood 2006, 108: 1352. DOI: 10.1182/blood.v108.11.1352.1352.
- Fu K, Weisenburger DD, Greiner TC, Dave S, Wright G, Rosenwald A, Chiorazzi M, Iqbal J, Gesk S, Siebert R, De Jong D, Jaffe ES, Wilson WH, Delabie J, Ott G, Dave BJ, Sanger WG, Smith LM, Rimsza L, Braziel RM, Müller-Hermelink H, Campo E, Gascoyne RD, Staudt LM, Chan C. Cyclin D1–negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood 2005, 106: 4315-4321. PMID: 16123218, PMCID: PMC1895253, DOI: 10.1182/blood-2005-04-1753.
- Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan W, Fisher RI, Braziel RM, Rimsza LM, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Connors JM, Lansdorp PM, Ouyang Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe ES, Simon R, Yang L, Powell J, Zhao H, Goldschmidt N, Chiorazzi M, Staudt LM. Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells. New England Journal Of Medicine 2004, 351: 2159-2169. PMID: 15548776, DOI: 10.1056/nejmoa041869.
- Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD, Chan WC, Zhao T, Haioun C, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Campo E, Montserrat E, Lopez-Guillermo A, Ott G, Muller-Hermelink HK, Connors JM, Braziel R, Grogan TM, Fisher RI, Miller TP, LeBlanc M, Chiorazzi M, Zhao H, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Staudt LM. Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma. Journal Of Experimental Medicine 2003, 198: 851-862. PMID: 12975453, PMCID: PMC2194208, DOI: 10.1084/jem.20031074.
- Rosenwald A, Wright G, Wiestner A, Chan C, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt LM. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 2003, 3: 185-197. PMID: 12620412, DOI: 10.1016/s1535-6108(03)00028-x.
Departments and Programs
Titles
- Assistant Professor of Internal Medicine (Medical Oncology)
Education & Training
- Post-Doctoral Fellow, ImmunobiologyYale School of Medicine (2019)
- Fellow, ABIM Research Pathway, Hematology & Medical OncologyYale School of Medicine (2018)
- Resident, ABIM Research Pathway, Internal MedicineYale School of Medicine (2014)
- PhDThe Rockefeller University (2012)
- MDCornell University Medical College (2012)
- BAWilliams College, Biology (2002)
Additional Information
Board Certifications
- AB of Internal Medicine, Medical Oncology (2022)
- AB of Internal Medicine, Internal Medicine (2016)
Publications
- Chiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins K, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze L, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Goedegebuure S, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Kluger Y, Palucka K, Fields R, Flavell R. Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment. Journal For ImmunoTherapy Of Cancer 2023, 11: e006921. PMID: 37487666, PMCID: PMC10373695, DOI: 10.1136/jitc-2023-006921.
- Tyagi T, Jain K, Yarovinsky TO, Chiorazzi M, Du J, Castro C, Griffin J, Korde A, Martin KA, Takyar SS, Flavell RA, Patel AA, Hwa J. Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells. Journal Of Experimental Medicine 2022, 220: e20212218. PMID: 36305874, PMCID: PMC9814191, DOI: 10.1084/jem.20212218.
- Martinek J, Lin J, Kim KI, Wang VG, Wu TC, Chiorazzi M, Boruchov H, Gulati A, Seeniraj S, Sun L, Marches F, Robson P, Rongvaux A, Flavell RA, George J, Chuang JH, Banchereau J, Palucka K. Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function. Cell Reports Medicine 2022, 3: 100621. PMID: 35584631, PMCID: PMC9133468, DOI: 10.1016/j.xcrm.2022.100621.
- Martinek J, Kim K, Lin J, Wu T, Borouchov H, Gulati A, Sun L, Wang V, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract 3441: Transcriptional profiles of CD14+ cells in situ in melanoma reveal plasticity, localization dependent function and specific T cell interactions. Cancer Research 2020, 80: 3441-3441. DOI: 10.1158/1538-7445.am2020-3441.
- Martinek J, in Kim K, Wu T, Boruchov H, Gulati A, Sun L, Wang V, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract A103: Transcriptional profiles of CD14+ cells in situ in melanoma reveal plasticity, localization-dependent function, and specific T-cell interactions. Cancer Immunology Research 2020, 8: a103-a103. DOI: 10.1158/2326-6074.tumimm19-a103.
- Martinek J, Kim K, Wu T, Wang V, Brookes H, Sun L, Gulati A, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract 1507: Transcriptional profiles of CD14+ cells in situ in melanoma tumors reveal plasticity and localization dependent function. 2019, 1507-1507. DOI: 10.1158/1538-7445.sabcs18-1507.
- Martinek J, Kim K, Wu T, Wang V, Brookes H, Sun L, Gulati A, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract 1507: Transcriptional profiles of CD14+ cells in situ in melanoma tumors reveal plasticity and localization dependent function. Cancer Research 2019, 79: 1507-1507. DOI: 10.1158/1538-7445.am2019-1507.
- Bailis W, Shyer JA, Chiorazzi M, Flavell RA. No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs. Cancer Cell 2017, 32: 280-281. PMID: 28898693, PMCID: PMC6939383, DOI: 10.1016/j.ccell.2017.08.013.
- Chiorazzi M, Rui L, Yang Y, Ceribelli M, Tishbi N, Maurer CW, Ranuncolo SM, Zhao H, Xu W, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Shaham S, Staudt LM. Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3943-3948. PMID: 23431138, PMCID: PMC3593917, DOI: 10.1073/pnas.1217271110.
- Hystad M, Myklebust J, Bø T, Sivertsen E, Rian E, Forfang L, Munthe E, Rosenwald A, Chiorazzi M, Jonassen I, Staudt L, Smeland E. Characterization of early stages of human B cell development by gene expression profiling. The Journal Of Immunology 2009, 182: 5882-5882. DOI: 10.4049/jimmunol.0990031.
- Hystad ME, Myklebust JH, Bø TH, Sivertsen EA, Rian E, Forfang L, Munthe E, Rosenwald A, Chiorazzi M, Jonassen I, Staudt LM, Smeland EB. Characterization of Early Stages of Human B Cell Development by Gene Expression Profiling. The Journal Of Immunology 2007, 179: 3662-3671. PMID: 17785802, DOI: 10.4049/jimmunol.179.6.3662.
- Maurer CW, Chiorazzi M, Shaham S. Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene. Development 2007, 134: 1357-1368. PMID: 17329362, DOI: 10.1242/dev.02818.
- Wiestner A, Tehrani M, Chiorazzi M, Wright G, Gibellini F, Nakayama K, Liu H, Rosenwald A, Muller-Hermelink HK, Ott G, Chan WC, Greiner TC, Weisenburger DD, Vose J, Armitage JO, Gascoyne RD, Connors JM, Campo E, Montserrat E, Bosch F, Smeland EB, Kvaloy S, Holte H, Delabie J, Fisher RI, Grogan TM, Miller TP, Wilson WH, Jaffe ES, Staudt LM. Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival. Blood 2007, 109: 4599-4606. PMID: 17299095, PMCID: PMC1885523, DOI: 10.1182/blood-2006-08-039859.
- Hystad M, Bo T, Rian E, Myklebust J, Sivertsen E, Forfang L, Chiorazzi M, Rosenwald A, Jonassen I, Staudt L, Smeland E. Characterization of Early Human B Cell Development by Gene Expression Profiling. Blood 2006, 108: 1352. DOI: 10.1182/blood.v108.11.1352.1352.
- Fu K, Weisenburger DD, Greiner TC, Dave S, Wright G, Rosenwald A, Chiorazzi M, Iqbal J, Gesk S, Siebert R, De Jong D, Jaffe ES, Wilson WH, Delabie J, Ott G, Dave BJ, Sanger WG, Smith LM, Rimsza L, Braziel RM, Müller-Hermelink H, Campo E, Gascoyne RD, Staudt LM, Chan C. Cyclin D1–negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood 2005, 106: 4315-4321. PMID: 16123218, PMCID: PMC1895253, DOI: 10.1182/blood-2005-04-1753.
- Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan W, Fisher RI, Braziel RM, Rimsza LM, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Connors JM, Lansdorp PM, Ouyang Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe ES, Simon R, Yang L, Powell J, Zhao H, Goldschmidt N, Chiorazzi M, Staudt LM. Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells. New England Journal Of Medicine 2004, 351: 2159-2169. PMID: 15548776, DOI: 10.1056/nejmoa041869.
- Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD, Chan WC, Zhao T, Haioun C, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Campo E, Montserrat E, Lopez-Guillermo A, Ott G, Muller-Hermelink HK, Connors JM, Braziel R, Grogan TM, Fisher RI, Miller TP, LeBlanc M, Chiorazzi M, Zhao H, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Staudt LM. Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma. Journal Of Experimental Medicine 2003, 198: 851-862. PMID: 12975453, PMCID: PMC2194208, DOI: 10.1084/jem.20031074.
- Rosenwald A, Wright G, Wiestner A, Chan C, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt LM. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 2003, 3: 185-197. PMID: 12620412, DOI: 10.1016/s1535-6108(03)00028-x.
Departments and Programs