Krupa Jani, MD, PhD

Jani K, Lu S, Murphy J, Romesser P, Jethwa K, Li D, Chundury A, Wu A, Hathout L, Hallemeier C, Jabbour S. Malignancies diagnosed before and after anal squamous cell carcinomas: A SEER registry analysis. Cancer Medicine 2021, 10: 3575-3583. PMID: 33960690, PMCID: PMC8178496, DOI: 10.1002/cam4.3909.

Jabbour S, Hallemeier C, Chang D, Lu S, Hristidis V, Jethwa K, Baclay J, Li D, Chakrani Z, Haddock M, Toesca D, Jani K, Wu A, Sandhyavenu H, Minneci M, Romesser P. Increased Incidence of Malignancy Before and after Chemoradiation for Anal Squamous Cell Carcinoma: A Multi-Institutional Analysis. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e597-e598. DOI: 10.1016/j.ijrobp.2020.07.1824.

Khullar K, Patel N, Anderson C, Chundury A, Carpizo D, Feingold D, Grandhi M, Hochster H, Jani K, Kennedy T, Langan R, Spencer K, August D, Jabbour S, Department of Radiation Oncology R, Department of Surgery R, Division of Surgical Oncology R, Division of Medical Oncology R. The Evolving Role of Radiotherapy in Locally Advanced Rectal Cancer and the Potential for Nonoperative Management. TouchREVIEWS In Oncology & Haematology 2020, 16: 43. PMID: 32832093, PMCID: PMC7439775, DOI: 10.17925/ohr.2020.16.1.43.

Diehl K, Ge E, Weinberg D, Jani K, Allis C, Muir T. PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 22152-22157. PMID: 31611394, PMCID: PMC6825254, DOI: 10.1073/pnas.1911775116.

Ge E, Jani K, Diehl K, Müller M, Muir T. Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2. Journal Of The American Chemical Society 2019, 141: 15029-15039. PMID: 31479253, PMCID: PMC6941475, DOI: 10.1021/jacs.9b02321.

Jani K, Jain S, Ge E, Diehl K, Lundgren S, Müller M, Lewis P, Muir T. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 8295-8300. PMID: 30967505, PMCID: PMC6486736, DOI: 10.1073/pnas.1819029116.

Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon-Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science 2016, 352: 844-849. PMID: 27174990, PMCID: PMC4928577, DOI: 10.1126/science.aac7272.

Jani K, Dalafave D. Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1). Bioinformatics And Biology Insights 2012, 6: bbi.s8971. PMID: 22399850, PMCID: PMC3290105, DOI: 10.4137/bbi.s8971.

Dalafave D, Jani K. Computational Design of Small Molecules with Druglike Properties. Biophysical Journal 2011, 100: 216a. DOI: 10.1016/j.bpj.2010.12.1393.