I. George Miller, Jr, MD

I. George Miller, Jr, MD
Pediatrics, Pediatric Infectious Diseases, Internal Medicine, Medical Oncology
Accepting new patients? Yes
Referrals required? From physicians only
Patient type treated: Child
Board Certified in Internal Medicine

Dr. Miller’s laboratory studies the mechanisms underlying the switch between latency and lytic replication of two oncogenic herpesviruses, Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus. Current experiments explore how viral and cellular transcription factors that selectively bind to methylated DNA control expression of viral and cellular genes, how cellular gene expression is selectively inhibited while viral gene expression is enhanced, and how viral DNA replication is regulated by cellular proteins. Recent studies focus on a new class of anti-viral agents that inhibit reactivation of Epstein-Barr virus from latency into lytic infection.