- Yale Medicine NeurologyYale Physicians Building800 Howard AvenueNew Haven, CT 06519
- Yale Medicine Neurology8 Devine StreetNorth Haven, CT 06473
Sayed (Ausim) Azizi, MD, PhD, FANA
Biography
Ausim Azizi, MD, PhD, is the clinical chief of neurodegenerative disorders and specializes in treating patients with cognitive and memory problems.
“More than 20 percent of the U.S. population is over age 65 and given that cognitive and memory disorders are more common in older adults, it’s an important public health issue,” Dr. Azizi says. “Memory and cognition are at the core of one’s personality and there is a stigma and fear attached to dementia. People worry about genetics and transmission, and patients worry about becoming a shell of themselves.”
Dr. Azizi says he focuses on family members and caregivers as well. “Dementia doesn’t just affect the patient. In fact, when a patient stops remembering things, they perhaps suffer the least,” he says. “So, it becomes more about working with family and caregivers to keep patients comfortable and independent and to support the care givers.”
The most rewarding part of his job, he says, is educating patients and families. “I enjoy teaching them about their conditions and how to maintain their independence and give them power to live with their disease and treat the disease as best as we can,” he says.
Dr. Azizi’s research is focused on taking the functional, social, and biological aspects of dementia and determining how to deliver the best quality care to patients, which will also help caregivers, families, and the community.
Education & Training
- PhDSouthwestern Medical Center, Neuroscience/Medicine (1990)
- MDSouthwestern Medical Center, Neuroscience/Medicine (1990)
Languages Spoken
- English
Additional Information
- United Council for Neurologic Subspecialties, Neurology (2017)
- United Council for Neurologic Subspecialties, Neurocritical Care (2010)
- Azizi S. A role for the prefrontal cortex in reward, punishment, and animal behavior: an anatomical/functional framework. Neuroscience Letters 2023, 808: 137296. DOI: 10.1016/j.neulet.2023.137296.
- Kim M, Cleymaet S, Kim S, Andres J, Ruchalski C, Kim Y, Azizi S, Sharrief A, Naqvi I. Interdisciplinary patient-centred poststroke care in Follow-up After Stroke, Screening and Treatment (FASST) clinic model: a proof-of-concept pilot study. Integrated Healthcare Journal 2022, 4: e000118. PMID: 37440858, PMCID: PMC10327447, DOI: 10.1136/ihj-2021-000118.
- Azizi S. Role of the cerebellum in the phenotype of neurodegenerative diseases: Mitigate or exacerbate? Neuroscience Letters 2021, 760: 136105. PMID: 34246702, DOI: 10.1016/j.neulet.2021.136105.
- Azizi S. Monoamines: Dopamine, Norepinephrine, and Serotonin, Beyond Modulation, “Switches” That Alter the State of Target Networks. The Neuroscientist 2020, 28: 121-143. PMID: 33292070, DOI: 10.1177/1073858420974336.
- Azizi S, Azizi S. Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells. Journal Of NeuroVirology 2020, 26: 631-641. PMID: 32876900, PMCID: PMC7465881, DOI: 10.1007/s13365-020-00903-7.
- Kim S, Kim Y, Andres J, Hellerslia V, Azizi S, Sharrief A, Naqvi I. Design and Implementation of a Multidisciplinary Integrated Stroke Prevention Clinic (P3.3-001). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p3.3-001.
- Azizi S, Azizi S. Synucleinopathies in neurodegenerative diseases: Accomplices, an inside job and selective vulnerability. Neuroscience Letters 2017, 672: 150-152. PMID: 29217261, DOI: 10.1016/j.neulet.2017.12.003.
- Kelley R, Azizi S. Milton Alter, MD, PhD (1929–2016). Neurology 2016, 87: 976-977. DOI: 10.1212/wnl.0000000000003074.
- Fox R, Chan A, Gold R, Phillips J, Selmaj K, Chang I, Novas M, Rana J, Marantz J, Ambler Z, Ehler E, Havrdova E, Meluzinova E, Rektor I, Talab R, Gold R, Hartung H, Csanyi A, Csiba L, Jakab G, Hintzen R, Polman C, Drozdowski W, Fryze W, Kochanowicz J, Kwiecinski H, Maciejek Z, Schimrigk S, Selmaj K, Szczudlik A, Wajgt A, Belova A, Boiko A, Elchaninov A, Kozlov V, Odinak M, Shvarkov S, Skoromets A, Stolyarov I, Vorobieva O, Zavalishin I, Hillert J, Olsson T, Kappos L, Eraksoy M, Karabudak R, Siva A, Giovannoni G, Hawkins C, Sharief M, Sharrack B, Confavreux C, Ware J, Barnett M, Paine M, Lechner-Scott J, Beran R, Chapman C, Schwartz R, Butzkueven H, Casse R, Macdonell R, Berger T, Fazekas F, Ransmayr G, Vass K, Belachew S, De Deyn P, Decoo D, Dubois B, Medaer R, Seeldrayers P, Sindic C, Gaer L, Vanopdenbosch L, Grgic S, Bar-Or A, Bhan V, Bouchard J, Christie S, Grammond P, Jacques F, Veloso F, Vorobeychik G, Brinar V, Demarin V, Rudež J, Soldo-Butković S, Vurdelja R, Ambler Z, Doležil D, Havrdova E, Kanovsky P, Meluzinova E, Nova'k J, Rektor I, Skoda O, Duchcovská M, Camu W, Antoanela P, Coman I, Confavreux C, Edan G, Gout O, Lebrun-Frenay C, Papeix A, Vermersch P, Bachus-Banaschak K, Berghoff M, Bethke F, Boldt H, Chan A, Diener H, Eisensehr I, Emrich P, Griewing B, Haas J, Heesen C, Hoffmann F, Hufnagel A, Heidenreich F, Kleiter I, Lüer W, Marckmann-Böenke S, Marziniak M, Stangel M, Oschmann P, Rosenkranz T, Schneider H, Siefjediers V, Springub J, Stangel M, Stögbauer F, Bergh F, Tiel-Wilck K, Tinschert K, Grigoriadis N, Karageorgiou C, Kyritsis A, Papadimitriou A, Thomaides T, Vlaikidis N, Salguero Gonzalez L, Chon D, Ordoñez Sarg H, Agrawal C, Behari M, Cu V, Dwivedee S, Kothari S, Kulkarni R, Kushwaha S, Meena A, Mehndiratta M, Chandra Mukherjee S, Pandit L, Shah A, Shukla R, Vijayan K, Achiron A, Flechter S, Milo R, Vaknin-Dembinsky A, Pozzilli C, Daskalovska V, Castro Farfan F, Rangel Guerra R, Leyva I, Oropeza de Alba J, Revilla R, Rivera J, Gavriliuc M, Groppa S, Odainic O, Sanders E, Hupperts R, Mason D, Timmings P, Willoughby E, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kleczkowska M, Kochanowicz J, Kwieciński H, Nowacki P, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Wajgt A, Zielinski T, Daskalovska V, Bajenaru A, Muresanu F, Nica S, Simu M, Drakulić S, Nadj C, Obradovic D, Vojinovic S, Turčáni P, Kahancová E, Kurca E, Lisý L, Krajnak V, Badenhorst F, Green J, Heckmann J, Isaacs M, Kappos L, Linnebank M, Müller S, Buchakchyys'ka N, Goloborodko A, Kobys T, Lebedynets V, Lytvynenko N, Nehrych T, Pasyura I, Ryabichenko T, Voloshina N, Duddy M, Hawkins C, Nicholas R, Palace J, Sharrack B, Silber E, Turner B, Camac A, Chumley W, Crayton H, Dixit S, Edwards K, English J, Freedman S, Gordon N, Gazda S, Goldstick L, Gottschalk P, Grazioli E, Grainger W, Green B, Grelinger B, Gudesblatt M, Gupta A, Hayat G, Hendin B, Henson L, Hentati A, Herrman C, Itkin A, Janus T, Kasper L, Lathi E, Mowry E, Parry G, Perel A, Rao T, Riskind P, Rizvi S, Rossman H, Scott T, Shafer S, Storey J, Thrower B, Rossen M, Tosches W, Trefts L, Turel A, Weinstock-Guttman B, Gold R, Kappos L, Arnold D, Bar-Or A, Giovannoni G, Selmaj K, Dawson K, Gallacher P, Milla C, Yang M, Antel J, Bakris G, Chung R, Kowey P, Polman C, Richert J, Seibert B, Ware J, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Kneebone C, Fedulau A, Likhachev S, Mikhailova E, Naumova H, Decoo D, Sindic C, Gaer L, Grgic S, Sinanovic O, Suljic E, Deleva N, Georgiev D, Haralanov L, Ivanova S, Manchev I, Minchev D, Stamenova P, Tournev I, Vacheva E, Zahariev Z, Howell R, Vindas A, Bar-Or A, Blevins G, Kremenchutzky M, Veloso F, Witt N, Habek M, Rudež J, Soldo-Butković S, Vurdelja R, Doležil D, Havrdova E, Nova'k J, Vaclavik D, Antsov K, Gross-Paju K, Haldre S, Palu A, Toomsoo T, Al Khedr A, Camu W, De Seze J, Debouverie M, Defer G, Labauge P, Moreau T, Rumbach L, Angnstwurm K, Benes H, Berthele A, Boldt H, Christopher A, Derfuß T, Eisensehr I, Emrich P, Feneberg W, Hoffmann F, Hohlfeld R, Hüntemann R, Kallmann B, Kieseier B, Kleiter I, Landefeld H, Lüer W, Masri S, Mäurer M, Nelles G, Oschmann P, Paschen C, Reifschneider G, Sailer M, Schimrigk S, Spiegel-Meixensberger M, Steinbrecher A, Storch-Hagenlocher B, Tackenberg B, Tiel-Wilck K, Karageorgiou C, Papathanasopoulos P, Thomaides T, Vlaikidis N, Arjundas D, Behari M, Shah S, Ghosh A, Ghosh P, Ichaporia N, Khurana D, Kulkarni R, Mehndiratta M, Mehta N, Misra U, Mukherji J, Nellikunja S, Radhakrishnan S, Salem A, Sethi P, Singh G, Lines C, Singh M, Singh Y, Srinivasa R, Vijayan K, Hutchinson M, Sweeney B, Gilad R, Shahien R, Metra M, Paegle A, Daskalovska V, Delgado C, Escamilla J, Estañol B, Lopez N, Macias M, Punzo G, Quiñones S, Renteria M, Santos C, Gavriliuc M, Groppa S, Odainic O, Timmings P, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kaminska A, Kapelusiak-Pielok M, Kleczkowska M, Kochanowicz J, Kwieciński H, Losy J, Nowacki P, Nyka W, Pierzchala K, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Szczudlik A, Tutaj A, Wajgt A, Zielinski T, Chinea A, Balasa R, Ionescu-Dimancea V, Mihancea P, Popescu C, Protosevici L, Drakulić S, Nadj C, Raicevic R, Vojinovic S, Kahancová E, Kurca E, Lisý L, Turčáni P, Arroyo R, Fernández O, Guijarro C, Izquierdo G, Montalbán X, Oreja-Guevara C, Prieto J, Lopez F, Buchakchyys'ka N, Chmyr G, Goloborodko A, Grytsay N, Kobys T, Kushnir G, Lebedynets V, Lytvynenko N, Moskovko S, Nehrych T, Palamar B, Pasyura I, Ryabichenko T, Voloshina N, Apperson M, Applebee A, Asher S, Ayala R, Ayres D, Azizi S, Baker M, Bauer B, Bomprezzi R, Buckler R, Carlini W, Cohan S, Crowell G, Edwards K, Eubank G, Felton W, Fodor P, Foley J, Ford C, Forester M, Fox E, Fox R, Freedman S, Garmany G, Gazda S, Giang D, Glaun B, Gold S, Gottesman M, Gudesblatt M, Herbert J, Herskowitz A, Honeycutt W, Huddlestone J, Hull R, Hunter S, Hutton G, Jacobs D, Janicki M, Khatri B, Kinkel R, Kita M, Krolczyk S, Krupp L, LaGanke C, Levin M, Licht J, Luzzio C, Lynch S, Mattson D, Mikol D, Miller T, Minagar A, Mitchell G, Moses H, Negroski D, Newman S, Pardo G, Patel M, Perel A, Phillips J, Picone M, Rammohan K, Rao T, Rinker J, Sadiq S, Schaeffer J, Sheremata W, Shin R, Shubin R, Silverman S, Smith R, Stein L, Stein M, Steiner D, Steingo B, Sullivan H, Sunter W, Vaishnav A, Vasquez A, Voci J, Warach J, Weinstock-Guttman B, Williams M, Wray S, Fox R, Phillips J, Hutchinson M, Havrdova E, Kita M, Wilson K, Yang M, Dawson K, Antel J, Ware J, Polman C, Kowey P, Chung R, Bakris G, Richert J, Seibert B, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Alfaro-Vidal T, Crespo C, Foster J, Hunter K, Garcia-Gomez A, MacManus D, Miller D, Santana V, Tozer D, Kingshott-Wheeler C, Yousry T. Characterizing absolute lymphocyte count profiles in dimethyl fumarate–treated patients with MS. Neurology Clinical Practice 2016, 6: 220-229. PMID: 27347439, PMCID: PMC4909524, DOI: 10.1212/cpj.0000000000000238.
- Mahta A, Katz P, Kamel H, Azizi S. Intracerebral hemorrhage with intraventricular extension and no hydrocephalus may not increase mortality or severe disability. Journal Of Clinical Neuroscience 2016, 30: 56-59. PMID: 26972705, DOI: 10.1016/j.jocn.2015.11.028.
- Patira R, Azizi S. The dementia factor: A retrospective analysis of care of patients with Dementia in tertiary medical center. (P6.178). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p6.178.
- Miller D, Fox R, Phillips J, Hutchinson M, Havrdova E, Kita M, Wheeler-Kingshott C, Tozer D, MacManus D, Yousry T, Goodsell M, Yang M, Zhang R, Viglietta V, Dawson K, Fox R, Phillips J, Hutchinson M, Havrdova E, Kita M, Wilson K, Yang M, Dawson K, Antel J, Ware J, Polman C, Kowey P, Chung R, Bakris G, Richert J, Seibert B, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Alfaro-Vidal T, Crespo C, Foster J, Hunter K, Garcia-Gomez A, MacManus D, Miller D, Santana V, Tozer D, Wheeler-Kingshott C, Yousry T, Kneebone C, Fedulau A, Likhachev S, Mikhailova E, Naumova H, Decoo D, Gaer L, Sindic C, Grgic S, Sinanovic O, Suljic E, Deleva N, Georgiev D, Haralanov L, Ivanova S, Manchev I, Minchev D, Stamenova P, Tournev I, Vacheva E, Zahariev Z, Bar-Or A, Blevins G, Kremenchutzky M, Veloso F, Witt N, Vargas Howell R, Vindas A, Habek M, Rudež J, Soldo-Butković S, Vurdelja R, Doležil D, Havrdova E, Nova'k J, Vaclavik D, Antsov K, Gross-Paju K, Haldre S, Palu A, Toomsoo T, Al Khedr A, Camu W, Debouverie M, Defer G, De Seze J, Labauge P, Moreau T, Pelletier J, Rumbach L, Daskalovska V, Angnstwurm K, Benes H, Berthele A, Boldt H, Christopher A, Derfuß T, Eisensehr I, Emrich P, Feneberg W, Hoffmann F, Hohlfeld R, Hüntemann R, Kallmann B, Kieseier B, Landefeld H, Lüer W, Masri S, Nelles G, Oschmann P, Paschen C, Reifschneider G, Sailer M, Schimrigk S, Spiegel-Meixensberger M, Storch-Hagenlocher B, Tackenberg B, Tiel-Wilck K, Karageorgiou C, Papathanasopoulos P, Thomaides T, Vlaikidis N, Arjundas D, Behari M, Ghosh A, Ghosh P, Ichaporia N, Khurana D, Kulkarni R, Kumar S, Mehndiratta M, Mehta N, Misra U, Mukherji J, Nellikunja S, Salem A, Sethi P, Shah S, Singh G, Singh M, Singh Y, Srinivasa R, Vijayan K, Hutchinson M, Sweeney B, Gilad R, Shahien R, Paegle A, Delgado C, Escamilla J, Estañol B, Lopez M, Macias M, Punzo G, Quiñones S, Renteria M, Santos J, Gavriliuc M, Groppa S, Odainic O, Timmings P, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kaminska A, Kapelusiak-Pielok M, Kleczkowska M, Kochanowicz J, Losy J, Nowacki P, Nyka W, Pierzchala K, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Szczudlik A, Tutaj A, Wajgt A, Zielinski T, Balasa R, Ionescu-Dimancea V, Mihancea P, Popescu C, Protosevici L, Miletić Drakulić S, Nadj C, Raicevic R, Vojinovic S, Kahancová E, Kurca E, Lisý L, Turčáni P, Arroyo R, Fernández O, Guijarro C, Izquierdo G, Lopez F, Montalbán X, Oreja-Guevara C, Prieto J, Buchakchyys'ka N, Chmyr G, Goloborodko A, Kobys T, Kushnir G, Lebedynets V, Lytvynenko N, Moskovko S, Nehrych T, Palamar B, Pasyura I, Ryabichenko T, Voloshina N, Apperson M, Applebee A, Asher S, Ayala R, Ayres D, Azizi S, Baker M, Bauer B, Bomprezzi R, Buckler R, Carlini W, Chinea A, Cohan S, Crowell G, Edwards K, Eubank G, Felton W, Fodor P, Foley J, Ford C, Fox E, Fox R, Forester M, Freedman S, Garmany G, Gazda S, Giang D, Glaun B, Gold S, Gottesman M, Gudesblatt M, Herbert J, Herskowitz A, Honeycutt W, Huddlestone J, Hull R, Hunter S, Hutton G, Jacobs D, Janicki M, Khatri B, Kinkel R, Kita M, Krolczyk S, Krupp L, LaGanke C, Levin M, Licht J, Luzzio C, Lynch S, Mattson D, Mikol D, Miller T, Minagar A, Mitchell G, Moses H, Negroski D, Newman S, Pardo G, Patel M, Perel A, Phillips J, Picone M, Rammohan K, Rao T, Rinker J, Sadiq S, Schaeffer J, Sheremata W, Shin R, Shubin R, Silverman S, Smith R, Stein L, Stein M, Steiner D, Steingo B, Sullivan H, Sunter W, Vaishnav A, Vasquez A, Voci J, Warach J, Weinstock-Guttman B, Williams M, Wray S. Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study. Neurology 2015, 84: 1145-1152. PMID: 25681448, PMCID: PMC4371413, DOI: 10.1212/wnl.0000000000001360.
- Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.Mukerjee R, Chang J, Del Valle L, Bagashev A, Gayed M, Lyde R, Hawkins B, Brailoiu E, Cohen E, Power C, Azizi S, Gelman B, Sawaya B. Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. Journal Of Biological Chemistry 2013, 288: 28310. PMCID: PMC3784745, DOI: 10.1074/jbc.a113.241547.
- Azizi S, Krynska B. Derivation of Neuronal Cells from Fetal Normal Human Astrocytes (NHA). Methods In Molecular Biology 2013, 1078: 89-96. PMID: 23975823, DOI: 10.1007/978-1-62703-640-5_8.
- Gordon J, Sariyer I, De La Fuente-Granada M, Augelli B, Otte J, Azizi S, Amini S, Khalili K, Krynska B. Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen. PLOS ONE 2013, 8: e65947. PMID: 23805194, PMCID: PMC3689770, DOI: 10.1371/journal.pone.0065947.
- Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.Mukerjee R, Chang J, Del Valle L, Bagashev A, Gayed M, Lyde R, Hawkins B, Brailoiu E, Cohen E, Power C, Azizi S, Gelman B, Sawaya B. Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. Journal Of Biological Chemistry 2013, 288: 8565. PMCID: PMC3605674, DOI: 10.1074/jbc.a111.241547.
- Azizi S. “I think therefore I am”: New prospects for neural prostheses. Neuroscience Letters 2013, 538: 1-2. PMID: 23298784, DOI: 10.1016/j.neulet.2012.12.015.
- Imitola J, Pitt K, Peoples J, Krynska B, Sheikh H, Kesari S, Azizi S. Erratum to: Multifocal CNS infiltration of chronic lymphocytic leukemia in the form of small-cell solid metastatic lesions. Journal Of Neuro-Oncology 2012, 109: 217-217. DOI: 10.1007/s11060-012-0899-z.
- Imitola J, Pitt K, Peoples J, Krynska B, Sheikh H, Kesari S, Azizi S. Multifocal CNS infiltration of chronic lymphocytic leukemia in the form of small-cell solid metastatic lesions. Journal Of Neuro-Oncology 2012, 109: 213-215. PMID: 22573347, DOI: 10.1007/s11060-012-0869-5.
- Mukerjee R, Chang J, Del Valle L, Bagashev A, Gayed M, Lyde R, Hawkins B, Cohen E, Power C, Azizi S, Sawaya B. Deregulation of microRNAs by HIV-1 Vpr leads to the development of neurocognitive disorders. Retrovirology 2011, 8: p51. PMCID: PMC3236941, DOI: 10.1186/1742-4690-8-s2-p51.
- Deregulation of microRNAs by HIV-1 Vpr Protein Leads to the Development of Neurocognitive Disorders*Mukerjee R, Chang J, Del Valle L, Bagashev A, Gayed M, Lyde R, Hawkins B, Brailoiu E, Cohen E, Power C, Azizi S, Gelman B, Sawaya B. Deregulation of microRNAs by HIV-1 Vpr Protein Leads to the Development of Neurocognitive Disorders*. Journal Of Biological Chemistry 2011, 286: 34976-34985. PMID: 21816823, PMCID: PMC3186354, DOI: 10.1074/jbc.m111.241547.
- Azizi S. Of sleep, seizures and networks. Neuroscience Letters 2011, 493: 61-62. PMID: 21352895, DOI: 10.1016/j.neulet.2011.02.031.
- Del Valle L, Piña-Oviedo S, Perez-Liz G, Augelli B, Azizi S, Khalili K, Gordon J, Krynska B. Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics. Cancer Biology & Therapy 2010, 9: 286-294. PMID: 20190567, PMCID: PMC2921558, DOI: 10.4161/cbt.9.4.10653.
- Azizi S. Brain to music to brain! Neuroscience Letters 2009, 459: 1-2. PMID: 19393289, DOI: 10.1016/j.neulet.2009.04.038.
- Rieske P, Augelli B, Stawski R, Gaughan J, Azizi S, Krynska B. A population of human brain cells expressing phenotypic markers of more than one lineage can be induced in vitro to differentiate into mesenchymal cells. Experimental Cell Research 2008, 315: 462-473. PMID: 19061885, DOI: 10.1016/j.yexcr.2008.11.004.
- Witusik M, Piaskowski S, Hulas-Bigoszewska K, Zakrzewska M, Gresner S, Azizi S, Krynska B, Liberski P, Rieske P. Successful elimination of non-neural cells and unachievable elimination of glial cells by means of commonly used cell culture manipulations during differentiation of GFAP and SOX2 positive neural progenitors (NHA) to neuronal cells. BMC Biotechnology 2008, 8: 56. PMID: 18638414, PMCID: PMC2488339, DOI: 10.1186/1472-6750-8-56.
- Franco M, Vendrame M, Haneef Z, Azizi S. Teaching NeuroImage: Acute spastic monoplegia secondary to spinal epidural venous engorgement in pregnancy. Neurology 2008, 71: e1. PMID: 18591496, DOI: 10.1212/01.wnl.0000316310.85132.b3.
- Azizi S. Neurology Board Review: An Illustrated Study Guide NimaMowzoonKelly D.FlemmingSleep: A Comprehensive Handbook2007Taylor & FrancisPhiladelphia, PA0-8493-3791-71003$149.95, (telephone: 800-354-1420). Mayo Clinic Proceedings 2008, 83: 374. DOI: 10.4065/83.3.374.
- Azizi S. . . . And the Olive Said to the Cerebellum: Organization and Functional Significance of the Olivo-Cerebellar System. The Neuroscientist 2007, 13: 616-625. PMID: 17911222, DOI: 10.1177/1073858407299286.
- Witusik M, Gresner S, Hulas-Bigoszewska K, Krynska B, Azizi S, Liberski P, Brown P, Rieske P. Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc. Brain Research 2007, 1186: 65-73. PMID: 17996224, DOI: 10.1016/j.brainres.2007.10.039.
- Vendrame M, Azizi S. Pyramidal and extrapyramidal dysfunction as a sequela of hypoxic injury: case report. BMC Neurology 2007, 7: 18. PMID: 17597529, PMCID: PMC1925116, DOI: 10.1186/1471-2377-7-18.
- Azizi S, Vendrame M. Exercise: A workout for neuroregeneration. Neuroscience Letters 2007, 418: 211-212. PMID: 17466455, DOI: 10.1016/j.neulet.2007.03.057.
- Rieske P, Azizi S, Augelli B, Gaughan J, Krynska B. A population of human brain parenchymal cells express markers of glial, neuronal and early neural cells and differentiate into cells of neuronal and glial lineages. European Journal Of Neuroscience 2007, 25: 31-37. PMID: 17241264, DOI: 10.1111/j.1460-9568.2006.05254.x.
- Vendrame M, Azizi S. The spectrum of neuromyelitis optica: a case of NMO with extensive brain stem involvement. Neurological Research 2007, 29: 32-35. PMID: 17427272, DOI: 10.1179/016164106x115071.
- Krynska B, Augelli B, Rieske P, Azizi S. A population of brain parenchymal cells expresses GFAP and βIII-tubulin and differentiates into neuronal and glial cells in vitro. Experimental Neurology 2006, 198: 575. DOI: 10.1016/j.expneurol.2006.02.058.
- Rieske P, Krynska B, Azizi S. Human fibroblast-derived cell lines have characteristics of embryonic stem cells and cells of neuro-ectodermal origin. Differentiation 2005, 73: 474-483. PMID: 16351691, DOI: 10.1111/j.1432-0436.2005.00050.x.
- Woodruff-Pak D, Thunahnai S, Doyle B, Pak H, Jørgensen O, Azizi S. [P‐128]: Apolipoprotein E isoform does not predict hipporcampal or entorhinal volume atrophy in nondemented older adults. Alzheimer's & Dementia 2005, 1: s50-s50. DOI: 10.1016/j.jalz.2005.06.201.
- Azizi S. Botulinum toxin: More than meets the naked eye! Neuroscience Letters 2005, 381: 205-206. PMID: 15896470, DOI: 10.1016/j.neulet.2005.04.008.
- Luo J, Jacobson M, Kamal A, Azizi S. Ethmoid abscess with findings simulating Weber syndrome. Neurology 2005, 64: 1266. PMID: 15824360, DOI: 10.1212/01.wn1.0000161487.06549.b7.
- Azizi S, Schwarz E, Prockop D, Alexander G, Mortati K, Krynska B. Utilization of Marrow Stromal Cells for Gene Transfer into the CNS. Contemporary Neuroscience 2003, 395-409. DOI: 10.1007/978-1-59259-298-2_15.
- Azizi S, Schwarz E, Prockop D, Alexander G, Mortati K, Krynska B. Utilization of Marrow Stromal Cells for Gene Transfer into the CNS. 2002, 0: 395-410. DOI: 10.1385/1-59259-298-8:395.
- Schwarz E, Reger R, Alexander G, Class R, Azizi S, Prockop D. Rat marrow stromal cells rapidly transduced with a self-inactivating retrovirus synthesize L-DOPA in vitro. Gene Therapy 2001, 8: 1214-1223. PMID: 11509954, DOI: 10.1038/sj.gt.3301517.
- Del Valle L, Azizi S, Krynska B, Enam S, Croul S, Khalili K. Reactivation of human neurotropic JC virus expressing oncogenic protein in a recurrent glioblastoma multiforme. Annals Of Neurology 2000, 48: 932-936. PMID: 11117551, DOI: 10.1002/1531-8249(200012)48:6<932::aid-ana15>3.0.co;2-e.
- Azizi S. Exploiting Nonneural Cells to Rebuild the Nervous System: From Bone Marrow to Brain. The Neuroscientist 2000, 6: 353-361. DOI: 10.1177/107385840000600509.
- Prockop D, Azizi S, Colter D, Digirolamo C, Kopen G, Phinney D. Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system. Biochemical Society Transactions 2000, 28: 341-5. PMID: 10961915, DOI: 10.1042/0300-5127:0280341.
- Prockop D, Azizi S, Colter D, DiGirolamo C, Kopen G, Phinney D. Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system. Biochemical Society Transactions 2000, 28: 341-345. DOI: 10.1042/bst0280341.
- Prockop D, Azizi S, Phinney D, Kopen G, Schwarz E. Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system. Progress In Brain Research 2000, 128: 293-297. PMID: 11105688, DOI: 10.1016/s0079-6123(00)28026-6.
- Schwarz E, Alexander G, Prockop D, Azizi S. Multipotential Marrow Stromal Cells Transduced to Produce L-DOPA: Engraftment in a Rat Model of Parkinson Disease. Human Gene Therapy 1999, 10: 2539-2549. PMID: 10543618, DOI: 10.1089/10430349950016870.
- Azizi S, Stokes D, Augelli B, DiGirolamo C, Prockop D. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats—similarities to astrocyte grafts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 3908-3913. PMID: 9520466, PMCID: PMC19936, DOI: 10.1073/pnas.95.7.3908.
- Azizi S, Miyamoto C. Principles of treatment of malignant gliomas in adults: an overview. Journal Of NeuroVirology 1998, 4: 204-16. PMID: 9584957, DOI: 10.3109/13550289809114520.
- Azizi S, Fayad P, Fulbright R, Giroux M, Waxman S. Clivus and cervical spinal osteomyelitis with epidural abscess presenting with multiple cranial neuropathies. Clinical Neurology And Neurosurgery 1995, 97: 239-244. PMID: 7586856, DOI: 10.1016/0303-8467(95)00036-j.
- Goldstein J, Azizi S, Booss J, Vollmer T. Human Immunodeficiency Virus—Associated Motor Axonal Polyradiculoneuropathy. JAMA Neurology 1993, 50: 1316-1319. PMID: 8257309, DOI: 10.1001/archneur.1993.00540120031009.
- Mihailoff G, Kosinski R, Azizi S, Lee H, Border B. The Expanding Role of the Basilar Pontine Nuclei as a Source of Cerebellar Afferents. 1992, 135-164. DOI: 10.1007/978-1-4612-2840-0_7.
- Azizi S, Woodward D. Interactions of visual and auditory mossy fiber inputs in the paraflocculus of the rat: a gating action of multimodal inputs. Brain Research 1990, 533: 255-262. PMID: 2289142, DOI: 10.1016/0006-8993(90)91347-j.
- Waterhouse B, Azizi S, Burne R, Woodward D. Modulation of rat cortical area 17 neuronal responses to moving visual stimuli during norepinephrine and serotonin microiontophoresis. Brain Research 1990, 514: 276-292. PMID: 2357542, DOI: 10.1016/0006-8993(90)91422-d.
- Mihailoff G, Kosinski R, Azizi S, Border B. Survey of noncortical afferent projections to the basilar pontine nuclei: A retrograde tracing study in the rat. The Journal Of Comparative Neurology 1989, 282: 617-643. PMID: 2723155, DOI: 10.1002/cne.902820411.
- Waterhouse B, Sessler F, Jung-Tung C, Woodward D, Azizi S, Moises H. New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain. Brain Research Bulletin 1988, 21: 425-432. PMID: 3214748, DOI: 10.1016/0361-9230(88)90154-2.
- Kosinski R, Azizi S, Mihailoff G. Convergence of cortico- and cuneopontine projections onto components of the pontocerebellar system in the rat: an anatomical and electrophysiological study. Experimental Brain Research 1988, 71: 541-556. PMID: 2458277, DOI: 10.1007/bf00248746.
- Cheng J, Sessler F, Azizi S, Chapin J, Waterhouse B. Electrophysiological actions of norepinephrine in rat lateral hypothalamus. II. An in vitro study of the effects of iontophoretically applied norepinephrine on LH neuronal responses to γ-aminobutyric acid (GABA). Brain Research 1988, 446: 90-105. PMID: 3370486, DOI: 10.1016/0006-8993(88)91299-1.
- Azizi S, Woodward D. Inferior olivary nuclear complex of the rat: Morphology and comments on the principles of organization within the olivocerebellar system. The Journal Of Comparative Neurology 1987, 263: 467-484. PMID: 2822777, DOI: 10.1002/cne.902630402.
- Kosinski R, Azizi S, Border B, Mihailoff B. Origin and ultrastructural identification of dorsal column nuclear synaptic terminals in the basilar pontine gray of rats. The Journal Of Comparative Neurology 1986, 253: 92-104. PMID: 2432100, DOI: 10.1002/cne.902530108.
- Border B, Kosinski R, Azizi S, Mihailoff G. Certain basilar pontine afferent systems are GABA-ergic: Combined HRP and immunocytochemical studies in the rat. Brain Research Bulletin 1986, 17: 169-179. PMID: 2429739, DOI: 10.1016/0361-9230(86)90113-9.
- Azizi S, Burne R, Woodward D. The auditory corticopontocerebellar projection in the rat: inputs to the paraflocculus and midvermis. An anatomical and physiological study. Experimental Brain Research 1985, 59: 36-49. PMID: 4018197, DOI: 10.1007/bf00237663.
- Woodward D, Smith W, Schlusselberg D, Azizi S, Chapin J. Tasks in Computer-Assisted Neuroanatomy: Data Acquisition, Imaging and Database. Wenner-Gren Symposium 1985, 25-40. DOI: 10.1007/978-1-349-08171-4_3.
- Woodward D, Smith W, Schlusselberg D, Azizi S, Chapin J. Tasks in Computer-Assisted Neuroanatomy: Data Acquisition, Imaging and Database. Wenner-Gren Center International Symposium Series 1985, 25-40. DOI: 10.1007/978-1-4613-2139-2_3.
- Burne R, Azizi S, Mihailoff G, Woodward D. The tectopontine projection in the rat with comments on visual pathways to the basilar pons. The Journal Of Comparative Neurology 1981, 202: 287-307. PMID: 6271853, DOI: 10.1002/cne.902020212.
- Azizi S, Mihailoff G, Burne R, Woodward D. The pontocerebellar system in the rat: An HRP study. I. Posterior vermis. The Journal Of Comparative Neurology 1981, 197: 543-558. PMID: 7229127, DOI: 10.1002/cne.901970402.
- Mihailoff G, Burne R, Azizi S, Norell G, Woodward D. The pontocerebellar system in the rat: An HRP study. II. Hemispheral components. The Journal Of Comparative Neurology 1981, 197: 559-577. PMID: 7229128, DOI: 10.1002/cne.901970403.
- Yale Medicine NeurologyYale Physicians Building800 Howard AvenueNew Haven, CT 06519
- Yale Medicine Neurology8 Devine StreetNorth Haven, CT 06473
Biography
Ausim Azizi, MD, PhD, is the clinical chief of neurodegenerative disorders and specializes in treating patients with cognitive and memory problems.
“More than 20 percent of the U.S. population is over age 65 and given that cognitive and memory disorders are more common in older adults, it’s an important public health issue,” Dr. Azizi says. “Memory and cognition are at the core of one’s personality and there is a stigma and fear attached to dementia. People worry about genetics and transmission, and patients worry about becoming a shell of themselves.”
Dr. Azizi says he focuses on family members and caregivers as well. “Dementia doesn’t just affect the patient. In fact, when a patient stops remembering things, they perhaps suffer the least,” he says. “So, it becomes more about working with family and caregivers to keep patients comfortable and independent and to support the care givers.”
The most rewarding part of his job, he says, is educating patients and families. “I enjoy teaching them about their conditions and how to maintain their independence and give them power to live with their disease and treat the disease as best as we can,” he says.
Dr. Azizi’s research is focused on taking the functional, social, and biological aspects of dementia and determining how to deliver the best quality care to patients, which will also help caregivers, families, and the community.
Education & Training
- PhDSouthwestern Medical Center, Neuroscience/Medicine (1990)
- MDSouthwestern Medical Center, Neuroscience/Medicine (1990)
Languages Spoken
- English
Additional Information
- United Council for Neurologic Subspecialties, Neurology (2017)
- United Council for Neurologic Subspecialties, Neurocritical Care (2010)
- Azizi S. A role for the prefrontal cortex in reward, punishment, and animal behavior: an anatomical/functional framework. Neuroscience Letters 2023, 808: 137296. DOI: 10.1016/j.neulet.2023.137296.
- Kim M, Cleymaet S, Kim S, Andres J, Ruchalski C, Kim Y, Azizi S, Sharrief A, Naqvi I. Interdisciplinary patient-centred poststroke care in Follow-up After Stroke, Screening and Treatment (FASST) clinic model: a proof-of-concept pilot study. Integrated Healthcare Journal 2022, 4: e000118. PMID: 37440858, PMCID: PMC10327447, DOI: 10.1136/ihj-2021-000118.
- Azizi S. Role of the cerebellum in the phenotype of neurodegenerative diseases: Mitigate or exacerbate? Neuroscience Letters 2021, 760: 136105. PMID: 34246702, DOI: 10.1016/j.neulet.2021.136105.
- Azizi S. Monoamines: Dopamine, Norepinephrine, and Serotonin, Beyond Modulation, “Switches” That Alter the State of Target Networks. The Neuroscientist 2020, 28: 121-143. PMID: 33292070, DOI: 10.1177/1073858420974336.
- Azizi S, Azizi S. Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells. Journal Of NeuroVirology 2020, 26: 631-641. PMID: 32876900, PMCID: PMC7465881, DOI: 10.1007/s13365-020-00903-7.
- Kim S, Kim Y, Andres J, Hellerslia V, Azizi S, Sharrief A, Naqvi I. Design and Implementation of a Multidisciplinary Integrated Stroke Prevention Clinic (P3.3-001). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p3.3-001.
- Azizi S, Azizi S. Synucleinopathies in neurodegenerative diseases: Accomplices, an inside job and selective vulnerability. Neuroscience Letters 2017, 672: 150-152. PMID: 29217261, DOI: 10.1016/j.neulet.2017.12.003.
- Kelley R, Azizi S. Milton Alter, MD, PhD (1929–2016). Neurology 2016, 87: 976-977. DOI: 10.1212/wnl.0000000000003074.
- Fox R, Chan A, Gold R, Phillips J, Selmaj K, Chang I, Novas M, Rana J, Marantz J, Ambler Z, Ehler E, Havrdova E, Meluzinova E, Rektor I, Talab R, Gold R, Hartung H, Csanyi A, Csiba L, Jakab G, Hintzen R, Polman C, Drozdowski W, Fryze W, Kochanowicz J, Kwiecinski H, Maciejek Z, Schimrigk S, Selmaj K, Szczudlik A, Wajgt A, Belova A, Boiko A, Elchaninov A, Kozlov V, Odinak M, Shvarkov S, Skoromets A, Stolyarov I, Vorobieva O, Zavalishin I, Hillert J, Olsson T, Kappos L, Eraksoy M, Karabudak R, Siva A, Giovannoni G, Hawkins C, Sharief M, Sharrack B, Confavreux C, Ware J, Barnett M, Paine M, Lechner-Scott J, Beran R, Chapman C, Schwartz R, Butzkueven H, Casse R, Macdonell R, Berger T, Fazekas F, Ransmayr G, Vass K, Belachew S, De Deyn P, Decoo D, Dubois B, Medaer R, Seeldrayers P, Sindic C, Gaer L, Vanopdenbosch L, Grgic S, Bar-Or A, Bhan V, Bouchard J, Christie S, Grammond P, Jacques F, Veloso F, Vorobeychik G, Brinar V, Demarin V, Rudež J, Soldo-Butković S, Vurdelja R, Ambler Z, Doležil D, Havrdova E, Kanovsky P, Meluzinova E, Nova'k J, Rektor I, Skoda O, Duchcovská M, Camu W, Antoanela P, Coman I, Confavreux C, Edan G, Gout O, Lebrun-Frenay C, Papeix A, Vermersch P, Bachus-Banaschak K, Berghoff M, Bethke F, Boldt H, Chan A, Diener H, Eisensehr I, Emrich P, Griewing B, Haas J, Heesen C, Hoffmann F, Hufnagel A, Heidenreich F, Kleiter I, Lüer W, Marckmann-Böenke S, Marziniak M, Stangel M, Oschmann P, Rosenkranz T, Schneider H, Siefjediers V, Springub J, Stangel M, Stögbauer F, Bergh F, Tiel-Wilck K, Tinschert K, Grigoriadis N, Karageorgiou C, Kyritsis A, Papadimitriou A, Thomaides T, Vlaikidis N, Salguero Gonzalez L, Chon D, Ordoñez Sarg H, Agrawal C, Behari M, Cu V, Dwivedee S, Kothari S, Kulkarni R, Kushwaha S, Meena A, Mehndiratta M, Chandra Mukherjee S, Pandit L, Shah A, Shukla R, Vijayan K, Achiron A, Flechter S, Milo R, Vaknin-Dembinsky A, Pozzilli C, Daskalovska V, Castro Farfan F, Rangel Guerra R, Leyva I, Oropeza de Alba J, Revilla R, Rivera J, Gavriliuc M, Groppa S, Odainic O, Sanders E, Hupperts R, Mason D, Timmings P, Willoughby E, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kleczkowska M, Kochanowicz J, Kwieciński H, Nowacki P, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Wajgt A, Zielinski T, Daskalovska V, Bajenaru A, Muresanu F, Nica S, Simu M, Drakulić S, Nadj C, Obradovic D, Vojinovic S, Turčáni P, Kahancová E, Kurca E, Lisý L, Krajnak V, Badenhorst F, Green J, Heckmann J, Isaacs M, Kappos L, Linnebank M, Müller S, Buchakchyys'ka N, Goloborodko A, Kobys T, Lebedynets V, Lytvynenko N, Nehrych T, Pasyura I, Ryabichenko T, Voloshina N, Duddy M, Hawkins C, Nicholas R, Palace J, Sharrack B, Silber E, Turner B, Camac A, Chumley W, Crayton H, Dixit S, Edwards K, English J, Freedman S, Gordon N, Gazda S, Goldstick L, Gottschalk P, Grazioli E, Grainger W, Green B, Grelinger B, Gudesblatt M, Gupta A, Hayat G, Hendin B, Henson L, Hentati A, Herrman C, Itkin A, Janus T, Kasper L, Lathi E, Mowry E, Parry G, Perel A, Rao T, Riskind P, Rizvi S, Rossman H, Scott T, Shafer S, Storey J, Thrower B, Rossen M, Tosches W, Trefts L, Turel A, Weinstock-Guttman B, Gold R, Kappos L, Arnold D, Bar-Or A, Giovannoni G, Selmaj K, Dawson K, Gallacher P, Milla C, Yang M, Antel J, Bakris G, Chung R, Kowey P, Polman C, Richert J, Seibert B, Ware J, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Kneebone C, Fedulau A, Likhachev S, Mikhailova E, Naumova H, Decoo D, Sindic C, Gaer L, Grgic S, Sinanovic O, Suljic E, Deleva N, Georgiev D, Haralanov L, Ivanova S, Manchev I, Minchev D, Stamenova P, Tournev I, Vacheva E, Zahariev Z, Howell R, Vindas A, Bar-Or A, Blevins G, Kremenchutzky M, Veloso F, Witt N, Habek M, Rudež J, Soldo-Butković S, Vurdelja R, Doležil D, Havrdova E, Nova'k J, Vaclavik D, Antsov K, Gross-Paju K, Haldre S, Palu A, Toomsoo T, Al Khedr A, Camu W, De Seze J, Debouverie M, Defer G, Labauge P, Moreau T, Rumbach L, Angnstwurm K, Benes H, Berthele A, Boldt H, Christopher A, Derfuß T, Eisensehr I, Emrich P, Feneberg W, Hoffmann F, Hohlfeld R, Hüntemann R, Kallmann B, Kieseier B, Kleiter I, Landefeld H, Lüer W, Masri S, Mäurer M, Nelles G, Oschmann P, Paschen C, Reifschneider G, Sailer M, Schimrigk S, Spiegel-Meixensberger M, Steinbrecher A, Storch-Hagenlocher B, Tackenberg B, Tiel-Wilck K, Karageorgiou C, Papathanasopoulos P, Thomaides T, Vlaikidis N, Arjundas D, Behari M, Shah S, Ghosh A, Ghosh P, Ichaporia N, Khurana D, Kulkarni R, Mehndiratta M, Mehta N, Misra U, Mukherji J, Nellikunja S, Radhakrishnan S, Salem A, Sethi P, Singh G, Lines C, Singh M, Singh Y, Srinivasa R, Vijayan K, Hutchinson M, Sweeney B, Gilad R, Shahien R, Metra M, Paegle A, Daskalovska V, Delgado C, Escamilla J, Estañol B, Lopez N, Macias M, Punzo G, Quiñones S, Renteria M, Santos C, Gavriliuc M, Groppa S, Odainic O, Timmings P, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kaminska A, Kapelusiak-Pielok M, Kleczkowska M, Kochanowicz J, Kwieciński H, Losy J, Nowacki P, Nyka W, Pierzchala K, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Szczudlik A, Tutaj A, Wajgt A, Zielinski T, Chinea A, Balasa R, Ionescu-Dimancea V, Mihancea P, Popescu C, Protosevici L, Drakulić S, Nadj C, Raicevic R, Vojinovic S, Kahancová E, Kurca E, Lisý L, Turčáni P, Arroyo R, Fernández O, Guijarro C, Izquierdo G, Montalbán X, Oreja-Guevara C, Prieto J, Lopez F, Buchakchyys'ka N, Chmyr G, Goloborodko A, Grytsay N, Kobys T, Kushnir G, Lebedynets V, Lytvynenko N, Moskovko S, Nehrych T, Palamar B, Pasyura I, Ryabichenko T, Voloshina N, Apperson M, Applebee A, Asher S, Ayala R, Ayres D, Azizi S, Baker M, Bauer B, Bomprezzi R, Buckler R, Carlini W, Cohan S, Crowell G, Edwards K, Eubank G, Felton W, Fodor P, Foley J, Ford C, Forester M, Fox E, Fox R, Freedman S, Garmany G, Gazda S, Giang D, Glaun B, Gold S, Gottesman M, Gudesblatt M, Herbert J, Herskowitz A, Honeycutt W, Huddlestone J, Hull R, Hunter S, Hutton G, Jacobs D, Janicki M, Khatri B, Kinkel R, Kita M, Krolczyk S, Krupp L, LaGanke C, Levin M, Licht J, Luzzio C, Lynch S, Mattson D, Mikol D, Miller T, Minagar A, Mitchell G, Moses H, Negroski D, Newman S, Pardo G, Patel M, Perel A, Phillips J, Picone M, Rammohan K, Rao T, Rinker J, Sadiq S, Schaeffer J, Sheremata W, Shin R, Shubin R, Silverman S, Smith R, Stein L, Stein M, Steiner D, Steingo B, Sullivan H, Sunter W, Vaishnav A, Vasquez A, Voci J, Warach J, Weinstock-Guttman B, Williams M, Wray S, Fox R, Phillips J, Hutchinson M, Havrdova E, Kita M, Wilson K, Yang M, Dawson K, Antel J, Ware J, Polman C, Kowey P, Chung R, Bakris G, Richert J, Seibert B, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Alfaro-Vidal T, Crespo C, Foster J, Hunter K, Garcia-Gomez A, MacManus D, Miller D, Santana V, Tozer D, Kingshott-Wheeler C, Yousry T. Characterizing absolute lymphocyte count profiles in dimethyl fumarate–treated patients with MS. Neurology Clinical Practice 2016, 6: 220-229. PMID: 27347439, PMCID: PMC4909524, DOI: 10.1212/cpj.0000000000000238.
- Mahta A, Katz P, Kamel H, Azizi S. Intracerebral hemorrhage with intraventricular extension and no hydrocephalus may not increase mortality or severe disability. Journal Of Clinical Neuroscience 2016, 30: 56-59. PMID: 26972705, DOI: 10.1016/j.jocn.2015.11.028.
- Patira R, Azizi S. The dementia factor: A retrospective analysis of care of patients with Dementia in tertiary medical center. (P6.178). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p6.178.
- Miller D, Fox R, Phillips J, Hutchinson M, Havrdova E, Kita M, Wheeler-Kingshott C, Tozer D, MacManus D, Yousry T, Goodsell M, Yang M, Zhang R, Viglietta V, Dawson K, Fox R, Phillips J, Hutchinson M, Havrdova E, Kita M, Wilson K, Yang M, Dawson K, Antel J, Ware J, Polman C, Kowey P, Chung R, Bakris G, Richert J, Seibert B, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Alfaro-Vidal T, Crespo C, Foster J, Hunter K, Garcia-Gomez A, MacManus D, Miller D, Santana V, Tozer D, Wheeler-Kingshott C, Yousry T, Kneebone C, Fedulau A, Likhachev S, Mikhailova E, Naumova H, Decoo D, Gaer L, Sindic C, Grgic S, Sinanovic O, Suljic E, Deleva N, Georgiev D, Haralanov L, Ivanova S, Manchev I, Minchev D, Stamenova P, Tournev I, Vacheva E, Zahariev Z, Bar-Or A, Blevins G, Kremenchutzky M, Veloso F, Witt N, Vargas Howell R, Vindas A, Habek M, Rudež J, Soldo-Butković S, Vurdelja R, Doležil D, Havrdova E, Nova'k J, Vaclavik D, Antsov K, Gross-Paju K, Haldre S, Palu A, Toomsoo T, Al Khedr A, Camu W, Debouverie M, Defer G, De Seze J, Labauge P, Moreau T, Pelletier J, Rumbach L, Daskalovska V, Angnstwurm K, Benes H, Berthele A, Boldt H, Christopher A, Derfuß T, Eisensehr I, Emrich P, Feneberg W, Hoffmann F, Hohlfeld R, Hüntemann R, Kallmann B, Kieseier B, Landefeld H, Lüer W, Masri S, Nelles G, Oschmann P, Paschen C, Reifschneider G, Sailer M, Schimrigk S, Spiegel-Meixensberger M, Storch-Hagenlocher B, Tackenberg B, Tiel-Wilck K, Karageorgiou C, Papathanasopoulos P, Thomaides T, Vlaikidis N, Arjundas D, Behari M, Ghosh A, Ghosh P, Ichaporia N, Khurana D, Kulkarni R, Kumar S, Mehndiratta M, Mehta N, Misra U, Mukherji J, Nellikunja S, Salem A, Sethi P, Shah S, Singh G, Singh M, Singh Y, Srinivasa R, Vijayan K, Hutchinson M, Sweeney B, Gilad R, Shahien R, Paegle A, Delgado C, Escamilla J, Estañol B, Lopez M, Macias M, Punzo G, Quiñones S, Renteria M, Santos J, Gavriliuc M, Groppa S, Odainic O, Timmings P, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kaminska A, Kapelusiak-Pielok M, Kleczkowska M, Kochanowicz J, Losy J, Nowacki P, Nyka W, Pierzchala K, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Szczudlik A, Tutaj A, Wajgt A, Zielinski T, Balasa R, Ionescu-Dimancea V, Mihancea P, Popescu C, Protosevici L, Miletić Drakulić S, Nadj C, Raicevic R, Vojinovic S, Kahancová E, Kurca E, Lisý L, Turčáni P, Arroyo R, Fernández O, Guijarro C, Izquierdo G, Lopez F, Montalbán X, Oreja-Guevara C, Prieto J, Buchakchyys'ka N, Chmyr G, Goloborodko A, Kobys T, Kushnir G, Lebedynets V, Lytvynenko N, Moskovko S, Nehrych T, Palamar B, Pasyura I, Ryabichenko T, Voloshina N, Apperson M, Applebee A, Asher S, Ayala R, Ayres D, Azizi S, Baker M, Bauer B, Bomprezzi R, Buckler R, Carlini W, Chinea A, Cohan S, Crowell G, Edwards K, Eubank G, Felton W, Fodor P, Foley J, Ford C, Fox E, Fox R, Forester M, Freedman S, Garmany G, Gazda S, Giang D, Glaun B, Gold S, Gottesman M, Gudesblatt M, Herbert J, Herskowitz A, Honeycutt W, Huddlestone J, Hull R, Hunter S, Hutton G, Jacobs D, Janicki M, Khatri B, Kinkel R, Kita M, Krolczyk S, Krupp L, LaGanke C, Levin M, Licht J, Luzzio C, Lynch S, Mattson D, Mikol D, Miller T, Minagar A, Mitchell G, Moses H, Negroski D, Newman S, Pardo G, Patel M, Perel A, Phillips J, Picone M, Rammohan K, Rao T, Rinker J, Sadiq S, Schaeffer J, Sheremata W, Shin R, Shubin R, Silverman S, Smith R, Stein L, Stein M, Steiner D, Steingo B, Sullivan H, Sunter W, Vaishnav A, Vasquez A, Voci J, Warach J, Weinstock-Guttman B, Williams M, Wray S. Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study. Neurology 2015, 84: 1145-1152. PMID: 25681448, PMCID: PMC4371413, DOI: 10.1212/wnl.0000000000001360.
- Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.Mukerjee R, Chang J, Del Valle L, Bagashev A, Gayed M, Lyde R, Hawkins B, Brailoiu E, Cohen E, Power C, Azizi S, Gelman B, Sawaya B. Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. Journal Of Biological Chemistry 2013, 288: 28310. PMCID: PMC3784745, DOI: 10.1074/jbc.a113.241547.
- Azizi S, Krynska B. Derivation of Neuronal Cells from Fetal Normal Human Astrocytes (NHA). Methods In Molecular Biology 2013, 1078: 89-96. PMID: 23975823, DOI: 10.1007/978-1-62703-640-5_8.
- Gordon J, Sariyer I, De La Fuente-Granada M, Augelli B, Otte J, Azizi S, Amini S, Khalili K, Krynska B. Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen. PLOS ONE 2013, 8: e65947. PMID: 23805194, PMCID: PMC3689770, DOI: 10.1371/journal.pone.0065947.
- Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.Mukerjee R, Chang J, Del Valle L, Bagashev A, Gayed M, Lyde R, Hawkins B, Brailoiu E, Cohen E, Power C, Azizi S, Gelman B, Sawaya B. Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. Journal Of Biological Chemistry 2013, 288: 8565. PMCID: PMC3605674, DOI: 10.1074/jbc.a111.241547.
- Azizi S. “I think therefore I am”: New prospects for neural prostheses. Neuroscience Letters 2013, 538: 1-2. PMID: 23298784, DOI: 10.1016/j.neulet.2012.12.015.
- Imitola J, Pitt K, Peoples J, Krynska B, Sheikh H, Kesari S, Azizi S. Erratum to: Multifocal CNS infiltration of chronic lymphocytic leukemia in the form of small-cell solid metastatic lesions. Journal Of Neuro-Oncology 2012, 109: 217-217. DOI: 10.1007/s11060-012-0899-z.
- Imitola J, Pitt K, Peoples J, Krynska B, Sheikh H, Kesari S, Azizi S. Multifocal CNS infiltration of chronic lymphocytic leukemia in the form of small-cell solid metastatic lesions. Journal Of Neuro-Oncology 2012, 109: 213-215. PMID: 22573347, DOI: 10.1007/s11060-012-0869-5.
- Mukerjee R, Chang J, Del Valle L, Bagashev A, Gayed M, Lyde R, Hawkins B, Cohen E, Power C, Azizi S, Sawaya B. Deregulation of microRNAs by HIV-1 Vpr leads to the development of neurocognitive disorders. Retrovirology 2011, 8: p51. PMCID: PMC3236941, DOI: 10.1186/1742-4690-8-s2-p51.
- Deregulation of microRNAs by HIV-1 Vpr Protein Leads to the Development of Neurocognitive Disorders*Mukerjee R, Chang J, Del Valle L, Bagashev A, Gayed M, Lyde R, Hawkins B, Brailoiu E, Cohen E, Power C, Azizi S, Gelman B, Sawaya B. Deregulation of microRNAs by HIV-1 Vpr Protein Leads to the Development of Neurocognitive Disorders*. Journal Of Biological Chemistry 2011, 286: 34976-34985. PMID: 21816823, PMCID: PMC3186354, DOI: 10.1074/jbc.m111.241547.
- Azizi S. Of sleep, seizures and networks. Neuroscience Letters 2011, 493: 61-62. PMID: 21352895, DOI: 10.1016/j.neulet.2011.02.031.
- Del Valle L, Piña-Oviedo S, Perez-Liz G, Augelli B, Azizi S, Khalili K, Gordon J, Krynska B. Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics. Cancer Biology & Therapy 2010, 9: 286-294. PMID: 20190567, PMCID: PMC2921558, DOI: 10.4161/cbt.9.4.10653.
- Azizi S. Brain to music to brain! Neuroscience Letters 2009, 459: 1-2. PMID: 19393289, DOI: 10.1016/j.neulet.2009.04.038.
- Rieske P, Augelli B, Stawski R, Gaughan J, Azizi S, Krynska B. A population of human brain cells expressing phenotypic markers of more than one lineage can be induced in vitro to differentiate into mesenchymal cells. Experimental Cell Research 2008, 315: 462-473. PMID: 19061885, DOI: 10.1016/j.yexcr.2008.11.004.
- Witusik M, Piaskowski S, Hulas-Bigoszewska K, Zakrzewska M, Gresner S, Azizi S, Krynska B, Liberski P, Rieske P. Successful elimination of non-neural cells and unachievable elimination of glial cells by means of commonly used cell culture manipulations during differentiation of GFAP and SOX2 positive neural progenitors (NHA) to neuronal cells. BMC Biotechnology 2008, 8: 56. PMID: 18638414, PMCID: PMC2488339, DOI: 10.1186/1472-6750-8-56.
- Franco M, Vendrame M, Haneef Z, Azizi S. Teaching NeuroImage: Acute spastic monoplegia secondary to spinal epidural venous engorgement in pregnancy. Neurology 2008, 71: e1. PMID: 18591496, DOI: 10.1212/01.wnl.0000316310.85132.b3.
- Azizi S. Neurology Board Review: An Illustrated Study Guide NimaMowzoonKelly D.FlemmingSleep: A Comprehensive Handbook2007Taylor & FrancisPhiladelphia, PA0-8493-3791-71003$149.95, (telephone: 800-354-1420). Mayo Clinic Proceedings 2008, 83: 374. DOI: 10.4065/83.3.374.
- Azizi S. . . . And the Olive Said to the Cerebellum: Organization and Functional Significance of the Olivo-Cerebellar System. The Neuroscientist 2007, 13: 616-625. PMID: 17911222, DOI: 10.1177/1073858407299286.
- Witusik M, Gresner S, Hulas-Bigoszewska K, Krynska B, Azizi S, Liberski P, Brown P, Rieske P. Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc. Brain Research 2007, 1186: 65-73. PMID: 17996224, DOI: 10.1016/j.brainres.2007.10.039.
- Vendrame M, Azizi S. Pyramidal and extrapyramidal dysfunction as a sequela of hypoxic injury: case report. BMC Neurology 2007, 7: 18. PMID: 17597529, PMCID: PMC1925116, DOI: 10.1186/1471-2377-7-18.
- Azizi S, Vendrame M. Exercise: A workout for neuroregeneration. Neuroscience Letters 2007, 418: 211-212. PMID: 17466455, DOI: 10.1016/j.neulet.2007.03.057.
- Rieske P, Azizi S, Augelli B, Gaughan J, Krynska B. A population of human brain parenchymal cells express markers of glial, neuronal and early neural cells and differentiate into cells of neuronal and glial lineages. European Journal Of Neuroscience 2007, 25: 31-37. PMID: 17241264, DOI: 10.1111/j.1460-9568.2006.05254.x.
- Vendrame M, Azizi S. The spectrum of neuromyelitis optica: a case of NMO with extensive brain stem involvement. Neurological Research 2007, 29: 32-35. PMID: 17427272, DOI: 10.1179/016164106x115071.
- Krynska B, Augelli B, Rieske P, Azizi S. A population of brain parenchymal cells expresses GFAP and βIII-tubulin and differentiates into neuronal and glial cells in vitro. Experimental Neurology 2006, 198: 575. DOI: 10.1016/j.expneurol.2006.02.058.
- Rieske P, Krynska B, Azizi S. Human fibroblast-derived cell lines have characteristics of embryonic stem cells and cells of neuro-ectodermal origin. Differentiation 2005, 73: 474-483. PMID: 16351691, DOI: 10.1111/j.1432-0436.2005.00050.x.
- Woodruff-Pak D, Thunahnai S, Doyle B, Pak H, Jørgensen O, Azizi S. [P‐128]: Apolipoprotein E isoform does not predict hipporcampal or entorhinal volume atrophy in nondemented older adults. Alzheimer's & Dementia 2005, 1: s50-s50. DOI: 10.1016/j.jalz.2005.06.201.
- Azizi S. Botulinum toxin: More than meets the naked eye! Neuroscience Letters 2005, 381: 205-206. PMID: 15896470, DOI: 10.1016/j.neulet.2005.04.008.
- Luo J, Jacobson M, Kamal A, Azizi S. Ethmoid abscess with findings simulating Weber syndrome. Neurology 2005, 64: 1266. PMID: 15824360, DOI: 10.1212/01.wn1.0000161487.06549.b7.
- Azizi S, Schwarz E, Prockop D, Alexander G, Mortati K, Krynska B. Utilization of Marrow Stromal Cells for Gene Transfer into the CNS. Contemporary Neuroscience 2003, 395-409. DOI: 10.1007/978-1-59259-298-2_15.
- Azizi S, Schwarz E, Prockop D, Alexander G, Mortati K, Krynska B. Utilization of Marrow Stromal Cells for Gene Transfer into the CNS. 2002, 0: 395-410. DOI: 10.1385/1-59259-298-8:395.
- Schwarz E, Reger R, Alexander G, Class R, Azizi S, Prockop D. Rat marrow stromal cells rapidly transduced with a self-inactivating retrovirus synthesize L-DOPA in vitro. Gene Therapy 2001, 8: 1214-1223. PMID: 11509954, DOI: 10.1038/sj.gt.3301517.
- Del Valle L, Azizi S, Krynska B, Enam S, Croul S, Khalili K. Reactivation of human neurotropic JC virus expressing oncogenic protein in a recurrent glioblastoma multiforme. Annals Of Neurology 2000, 48: 932-936. PMID: 11117551, DOI: 10.1002/1531-8249(200012)48:6<932::aid-ana15>3.0.co;2-e.
- Azizi S. Exploiting Nonneural Cells to Rebuild the Nervous System: From Bone Marrow to Brain. The Neuroscientist 2000, 6: 353-361. DOI: 10.1177/107385840000600509.
- Prockop D, Azizi S, Colter D, Digirolamo C, Kopen G, Phinney D. Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system. Biochemical Society Transactions 2000, 28: 341-5. PMID: 10961915, DOI: 10.1042/0300-5127:0280341.
- Prockop D, Azizi S, Colter D, DiGirolamo C, Kopen G, Phinney D. Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system. Biochemical Society Transactions 2000, 28: 341-345. DOI: 10.1042/bst0280341.
- Prockop D, Azizi S, Phinney D, Kopen G, Schwarz E. Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system. Progress In Brain Research 2000, 128: 293-297. PMID: 11105688, DOI: 10.1016/s0079-6123(00)28026-6.
- Schwarz E, Alexander G, Prockop D, Azizi S. Multipotential Marrow Stromal Cells Transduced to Produce L-DOPA: Engraftment in a Rat Model of Parkinson Disease. Human Gene Therapy 1999, 10: 2539-2549. PMID: 10543618, DOI: 10.1089/10430349950016870.
- Azizi S, Stokes D, Augelli B, DiGirolamo C, Prockop D. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats—similarities to astrocyte grafts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 3908-3913. PMID: 9520466, PMCID: PMC19936, DOI: 10.1073/pnas.95.7.3908.
- Azizi S, Miyamoto C. Principles of treatment of malignant gliomas in adults: an overview. Journal Of NeuroVirology 1998, 4: 204-16. PMID: 9584957, DOI: 10.3109/13550289809114520.
- Azizi S, Fayad P, Fulbright R, Giroux M, Waxman S. Clivus and cervical spinal osteomyelitis with epidural abscess presenting with multiple cranial neuropathies. Clinical Neurology And Neurosurgery 1995, 97: 239-244. PMID: 7586856, DOI: 10.1016/0303-8467(95)00036-j.
- Goldstein J, Azizi S, Booss J, Vollmer T. Human Immunodeficiency Virus—Associated Motor Axonal Polyradiculoneuropathy. JAMA Neurology 1993, 50: 1316-1319. PMID: 8257309, DOI: 10.1001/archneur.1993.00540120031009.
- Mihailoff G, Kosinski R, Azizi S, Lee H, Border B. The Expanding Role of the Basilar Pontine Nuclei as a Source of Cerebellar Afferents. 1992, 135-164. DOI: 10.1007/978-1-4612-2840-0_7.
- Azizi S, Woodward D. Interactions of visual and auditory mossy fiber inputs in the paraflocculus of the rat: a gating action of multimodal inputs. Brain Research 1990, 533: 255-262. PMID: 2289142, DOI: 10.1016/0006-8993(90)91347-j.
- Waterhouse B, Azizi S, Burne R, Woodward D. Modulation of rat cortical area 17 neuronal responses to moving visual stimuli during norepinephrine and serotonin microiontophoresis. Brain Research 1990, 514: 276-292. PMID: 2357542, DOI: 10.1016/0006-8993(90)91422-d.
- Mihailoff G, Kosinski R, Azizi S, Border B. Survey of noncortical afferent projections to the basilar pontine nuclei: A retrograde tracing study in the rat. The Journal Of Comparative Neurology 1989, 282: 617-643. PMID: 2723155, DOI: 10.1002/cne.902820411.
- Waterhouse B, Sessler F, Jung-Tung C, Woodward D, Azizi S, Moises H. New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain. Brain Research Bulletin 1988, 21: 425-432. PMID: 3214748, DOI: 10.1016/0361-9230(88)90154-2.
- Kosinski R, Azizi S, Mihailoff G. Convergence of cortico- and cuneopontine projections onto components of the pontocerebellar system in the rat: an anatomical and electrophysiological study. Experimental Brain Research 1988, 71: 541-556. PMID: 2458277, DOI: 10.1007/bf00248746.
- Cheng J, Sessler F, Azizi S, Chapin J, Waterhouse B. Electrophysiological actions of norepinephrine in rat lateral hypothalamus. II. An in vitro study of the effects of iontophoretically applied norepinephrine on LH neuronal responses to γ-aminobutyric acid (GABA). Brain Research 1988, 446: 90-105. PMID: 3370486, DOI: 10.1016/0006-8993(88)91299-1.
- Azizi S, Woodward D. Inferior olivary nuclear complex of the rat: Morphology and comments on the principles of organization within the olivocerebellar system. The Journal Of Comparative Neurology 1987, 263: 467-484. PMID: 2822777, DOI: 10.1002/cne.902630402.
- Kosinski R, Azizi S, Border B, Mihailoff B. Origin and ultrastructural identification of dorsal column nuclear synaptic terminals in the basilar pontine gray of rats. The Journal Of Comparative Neurology 1986, 253: 92-104. PMID: 2432100, DOI: 10.1002/cne.902530108.
- Border B, Kosinski R, Azizi S, Mihailoff G. Certain basilar pontine afferent systems are GABA-ergic: Combined HRP and immunocytochemical studies in the rat. Brain Research Bulletin 1986, 17: 169-179. PMID: 2429739, DOI: 10.1016/0361-9230(86)90113-9.
- Azizi S, Burne R, Woodward D. The auditory corticopontocerebellar projection in the rat: inputs to the paraflocculus and midvermis. An anatomical and physiological study. Experimental Brain Research 1985, 59: 36-49. PMID: 4018197, DOI: 10.1007/bf00237663.
- Woodward D, Smith W, Schlusselberg D, Azizi S, Chapin J. Tasks in Computer-Assisted Neuroanatomy: Data Acquisition, Imaging and Database. Wenner-Gren Symposium 1985, 25-40. DOI: 10.1007/978-1-349-08171-4_3.
- Woodward D, Smith W, Schlusselberg D, Azizi S, Chapin J. Tasks in Computer-Assisted Neuroanatomy: Data Acquisition, Imaging and Database. Wenner-Gren Center International Symposium Series 1985, 25-40. DOI: 10.1007/978-1-4613-2139-2_3.
- Burne R, Azizi S, Mihailoff G, Woodward D. The tectopontine projection in the rat with comments on visual pathways to the basilar pons. The Journal Of Comparative Neurology 1981, 202: 287-307. PMID: 6271853, DOI: 10.1002/cne.902020212.
- Azizi S, Mihailoff G, Burne R, Woodward D. The pontocerebellar system in the rat: An HRP study. I. Posterior vermis. The Journal Of Comparative Neurology 1981, 197: 543-558. PMID: 7229127, DOI: 10.1002/cne.901970402.
- Mihailoff G, Burne R, Azizi S, Norell G, Woodward D. The pontocerebellar system in the rat: An HRP study. II. Hemispheral components. The Journal Of Comparative Neurology 1981, 197: 559-577. PMID: 7229128, DOI: 10.1002/cne.901970403.
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