Peter M. Glazer, MD, PhD
Biography
Radiation oncologist Peter M. Glazer, MD, PhD, is the chair of the Department of Therapeutic Radiology. He has dedicated his career to helping cancer patients receive the highest quality of care available in a supportive environment.
“When patients are undergoing radiotherapy for cancer, it can be a sensitive and challenging time for them and their families,” he says. “Our team does everything possible to keep our patients safe and comfortable throughout treatment.”
Dr. Glazer makes it his priority to provide patients seeking care at Smilow Cancer Hospital and its Care Centers with the most advanced technologies and evidence-based treatments. “We take great pride in giving our physicians the best tools to treat cancer,” he says.
As a professor of both therapeutic radiology and genetics at Yale School of Medicine, Dr. Glazer researches new therapeutic strategies for treating cancer and the role of altered DNA repair in tumor progression. His research was recently recognized by the National Cancer Institute of the NIH with a prestigious Outstanding Investigator Award of $7 million that will support his efforts to develop novel DNA repair inhibitors for cancer therapy.
Titles
- Robert E. Hunter Professor of Therapeutic Radiology and Professor of Genetics
- Chair, Therapeutic Radiology
Education & Training
- ResidentYale-New Haven Hospital (1991)
- PhDYale University (1987)
- MDYale University (1987)
- MScUniversity of Oxford, Biochemistry (1981)
- BAHarvard University, Chemistry (1979)
Additional Information
- Elected to the National Academy of Medicine 2022: National Academy of Medicine (2022)
- AB of Radiology, Radiation Oncology (1992)
- Gupta A, Barone C, Quijano E, Piotrowski-Daspit A, Perera J, Riccardi A, Jamali H, Turchick A, Zao W, Saltzman W, Glazer P, Egan M. Next generation triplex-forming PNAs for site-specific genome editing of the F508del CFTR mutation. Journal Of Cystic Fibrosis 2024 PMID: 39107154, DOI: 10.1016/j.jcf.2024.07.009.
- Carufe K, Economos N, Glazer P. Peptide Nucleic Acid-Mediated Regulation of CRISPR-Cas9 Specificity. Nucleic Acid Therapeutics 2024 PMID: 39037032, DOI: 10.1089/nat.2024.0007.
- Lynn A, Glazer P, Saltzman W, Stitelman D. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Current Stem Cell Reports 2024, 10: 30-36. DOI: 10.1007/s40778-024-00235-w.
- Altwerger G, Ghazarian M, Glazer P. Harnessing the effects of hypoxia-like inhibition on homology-directed DNA repair. Seminars In Cancer Biology 2023, 98: 11-18. PMID: 38029867, PMCID: PMC10872265, DOI: 10.1016/j.semcancer.2023.11.007.
- Zhang M, Zhao J, Glazer P, Bai W, Bepler G, Zhang X. Acetylation of MLH1 by CBP increases cellular DNA mismatch repair activity. The Journal Of Biochemistry 2023, 174: 183-191. PMID: 37094360, DOI: 10.1093/jb/mvad034.
- Takahashi T, Stoiljkovic M, Song E, Gao X, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu Z, Kristant A, Zhang Y, Sulkowski P, Glazer P, Kaczmarek L, Horvath T, Iwasaki A. Response to: Elevated L1 expression in ataxia telangiectasia likely explained by an RNA-seq batch effect. Neuron 2023, 111: 612-613. PMID: 36863323, DOI: 10.1016/j.neuron.2023.02.006.
- Putman R, Ricciardi A, Carufe K, Quijano E, Bahal R, Glazer P, Saltzman W. Nanoparticle‐mediated genome editing in single‐cell embryos via peptide nucleic acids. Bioengineering & Translational Medicine 2022, 8: e10458. PMID: 37206203, PMCID: PMC10189434, DOI: 10.1002/btm2.10458.
- Kim JW, McKay RR, Radke MR, Zhao S, Taplin ME, Davis NB, Monk P, Appleman LJ, Lara PN, Vaishampayan UN, Zhang J, Paul AK, Bubley G, Van Allen EM, Unlu S, Huang Y, Loda M, Shapiro GI, Glazer PM, LoRusso PM, Ivy SP, Shyr Y, Swisher EM, Petrylak DP. Randomized Trial of Olaparib With or Without Cediranib for Metastatic Castration-Resistant Prostate Cancer: The Results From National Cancer Institute 9984. Journal Of Clinical Oncology 2022, 41: 871-880. PMID: 36256912, PMCID: PMC9901975, DOI: 10.1200/jco.21.02947.
- Piotrowski-Daspit AS, Barone C, Lin CY, Deng Y, Wu D, Binns TC, Xu E, Ricciardi AS, Putman R, Garrison A, Nguyen R, Gupta A, Fan R, Glazer PM, Saltzman WM, Egan ME. In vivo correction of cystic fibrosis mediated by PNA nanoparticles. Science Advances 2022, 8: eabo0522. PMID: 36197984, PMCID: PMC9534507, DOI: 10.1126/sciadv.abo0522.
- Singh C, Bindra RS, Glazer PM, Vasquez JC, Pashankar F. Metastatic and multiply relapsed SDH‐deficient GIST and paraganglioma displays clinical response to combined poly ADP‐ribose polymerase inhibition and temozolomide. Pediatric Blood & Cancer 2022, 70: e30020. PMID: 36151992, DOI: 10.1002/pbc.30020.
- Takahashi T, Stoiljkovic M, Song E, Gao XB, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu ZW, Kristant A, Zhang Y, Sulkowski P, Glazer PM, Kaczmarek LK, Horvath TL, Iwasaki A. LINE-1 activation in the cerebellum drives ataxia. Neuron 2022, 110: 3278-3287.e8. PMID: 36070749, PMCID: PMC9588660, DOI: 10.1016/j.neuron.2022.08.011.
- Economos NG, Thapar U, Balasubramanian N, Karras GI, Glazer PM. An ELISA-based platform for rapid identification of structure-dependent nucleic acid–protein interactions detects novel DNA triplex interactors. Journal Of Biological Chemistry 2022, 298: 102398. PMID: 35988651, PMCID: PMC9493393, DOI: 10.1016/j.jbc.2022.102398.
- Economos NG, Quijano E, Carufe KEW, Perera JDR, Glazer PM. Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation. Nucleic Acids Research 2022, 50: e59-e59. PMID: 35235944, PMCID: PMC9177974, DOI: 10.1093/nar/gkac095.
- Dow J, Glazer P. Chapter 11 Oncometabolites, epigenetic marks, and DNA repair. 2022, 191-202. DOI: 10.1016/b978-0-323-91081-1.00008-x.
- Dow J, Krysztofiak A, Liu Y, Colon-Rios DA, Rogers FA, Glazer PM. Vulnerability of IDH1 mutant cancers to histone deacetylase inhibition via orthogonal suppression of DNA repair. Molecular Cancer Research 2021, 19: molcanres.mcr-21-0456-e.2021. PMID: 34535560, PMCID: PMC8642278, DOI: 10.1158/1541-7786.mcr-21-0456.
- Hayman TJ, Glazer PM. Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery. International Journal Of Molecular Sciences 2021, 22: 12761. PMID: 34884568, PMCID: PMC8657976, DOI: 10.3390/ijms222312761.
- Piotrowski-Daspit A, Bracaglia L, Barone C, Nguyen R, Glazer P, Egan M, Saltzman W. 582: In vivo nanoparticle-mediated therapeutic nucleic acid delivery for CF treatment. Journal Of Cystic Fibrosis 2021, 20: s277. DOI: 10.1016/s1569-1993(21)02005-1.
- Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Van Doorn J, Jones K, Moore H, Lopresti-Morrow L, Paradis T, Tylaska L, Zhang Q, Visca H, Reshetnyak YK, Andreev OA, Engelman DM, Glazer PM, Bindra RS, Paralkar VM. Correction to ‘Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity’. NAR Cancer 2021, 3: zcab047. PMID: 34888524, PMCID: PMC8651162, DOI: 10.1093/narcan/zcab047.
- Perera JDR, Carufe KEW, Glazer PM. Peptide nucleic acids and their role in gene regulation and editing. Biopolymers 2021, 112: e23460. PMID: 34129732, DOI: 10.1002/bip.23460.
- Raimundo L, Paterna A, Calheiros J, Ribeiro J, Cardoso DSP, Piga I, Neto SJ, Hegan D, Glazer PM, Indraccolo S, Mulhovo S, Costa JL, Ferreira M, Saraiva L. BBIT20 inhibits homologous DNA repair with disruption of the BRCA1–BARD1 interaction in breast and ovarian cancer. British Journal Of Pharmacology 2021, 178: 3627-3647. PMID: 33899955, PMCID: PMC9124438, DOI: 10.1111/bph.15506.
- Kim J, Cardin DB, Vaishampayan UN, Kato S, Grossman SR, Glazer P, Shyr Y, Ivy SP, LoRusso P. Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation. The Oncologist 2021, 26: e1104-e1109. PMID: 33742489, PMCID: PMC8265343, DOI: 10.1002/onco.13758.
- Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Van Doorn J, Jones K, Moore H, Lopresti-Morrow L, Paradis T, Tylaska L, Zhang Q, Visca H, Reshetnyak YK, Andreev OA, Engelman DM, Glazer PM, Bindra RS, Paralkar VM. Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity. NAR Cancer 2021, 3: zcab021. PMID: 34316708, PMCID: PMC8210154, DOI: 10.1093/narcan/zcab021.
- Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J. The NIH Somatic Cell Genome Editing program. Nature 2021, 592: 195-204. PMID: 33828315, PMCID: PMC8026397, DOI: 10.1038/s41586-021-03191-1.
- Dong YL, Vadla GP, Lu J, Ahmad V, Klein TJ, Liu LF, Glazer PM, Xu T, Chabu CY. Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance. Communications Biology 2021, 4: 374. PMID: 33742110, PMCID: PMC7979758, DOI: 10.1038/s42003-021-01898-5.
- Dharmaratne NU, Kaplan AR, Glazer PM. Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides. Cells 2021, 10: 541. PMID: 33806273, PMCID: PMC8000199, DOI: 10.3390/cells10030541.
- Eder JP, Doroshow DB, T. K, Keedy VL, Sklar JS, Glazer P, Bindra R, Shapiro GI. Clinical Efficacy of Olaparib in IDH1/IDH2-Mutant Mesenchymal Sarcomas. JCO Precision Oncology 2021, 5: 466-472. PMID: 34994649, PMCID: PMC9848565, DOI: 10.1200/po.20.00247.
- Ullrich SJ, Freedman-Weiss M, Ahle S, Mandl HK, Piotrowski-Daspit AS, Roberts K, Yung N, Maassel N, Bauer-Pisani T, Ricciardi AS, Egan ME, Glazer PM, Saltzman WM, Stitelman DH. Nanoparticles for delivery of agents to fetal lungs. Acta Biomaterialia 2021, 123: 346-353. PMID: 33484911, PMCID: PMC7962939, DOI: 10.1016/j.actbio.2021.01.024.
- Lu Y, Liu Y, Oeck S, Zhang GJ, Schramm A, Glazer PM. Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway. Cancer Research 2020, 80: 4655-4667. PMID: 32873635, PMCID: PMC7642024, DOI: 10.1158/0008-5472.can-20-1192.
- Sulkowski PL, Oeck S, Dow J, Economos NG, Mirfakhraie L, Liu Y, Noronha K, Bao X, Li J, Shuch BM, King MC, Bindra RS, Glazer PM. Oncometabolites suppress DNA repair by disrupting local chromatin signalling. Nature 2020, 582: 586-591. PMID: 32494005, PMCID: PMC7319896, DOI: 10.1038/s41586-020-2363-0.
- Kaplan AR, Pham H, Liu Y, Oyaghire S, Bahal R, Engelman DM, Glazer PM. Ku80-Targeted pH-Sensitive Peptide–PNA Conjugates Are Tumor Selective and Sensitize Cancer Cells to Ionizing Radiation. Molecular Cancer Research 2020, 18: 873-882. PMID: 32098827, PMCID: PMC7272299, DOI: 10.1158/1541-7786.mcr-19-0661.
- Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. Mitochondrial DNA stress signalling protects the nuclear genome. Nature Metabolism 2019, 1: 1209-1218. PMID: 32395698, PMCID: PMC7213273, DOI: 10.1038/s42255-019-0150-8.
- Kaplan AR, Glazer PM. Impact of hypoxia on DNA repair and genome integrity. Mutagenesis 2019, 35: 61-68. PMID: 31282537, PMCID: PMC7317153, DOI: 10.1093/mutage/gez019.
- Bindra R, Sundaram R, Aiello R, Marshall D, Bourassa P, Csengery J, Zhang Q, Robinson B, lopresti-Morrow L, Bechtold J, Tylaska L, Paradis T, Paralkar V, Hellsund P, Glazer P. Unlocking PARP inhibitor efficacy for HRD-negative cancers using the alphalex tumor targeting platform inhibitor efficacy for HRD-negative cancers using the alphalex tumor targeting platform. Journal Of Clinical Oncology 2019, 37: e14664-e14664. DOI: 10.1200/jco.2019.37.15_suppl.e14664.
- Kaplan AR, Gueble SE, Liu Y, Oeck S, Kim H, Yun Z, Glazer PM. Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51. Science Translational Medicine 2019, 11 PMID: 31092693, PMCID: PMC6626544, DOI: 10.1126/scitranslmed.aav4508.
- Piotrowski-Daspit AS, Glazer P, Saltzman WM. Debugging the genetic code: non-viral in vivo delivery of therapeutic genome editing technologies. Current Opinion In Biomedical Engineering 2018, 7: 24-32. PMID: 30984891, PMCID: PMC6456264, DOI: 10.1016/j.cobme.2018.08.002.
- Sulkowski PL, Scanlon SE, Oeck S, Glazer PM. PTEN Regulates Non-Homologous End Joining by Epigenetic Induction of NHEJ1/XLF. Molecular Cancer Research 2018, 16: molcanres.0581.2017. PMID: 29739874, PMCID: PMC6072556, DOI: 10.1158/1541-7786.mcr-17-0581.
- Sulkowski PL, Sundaram RK, Oeck S, Corso CD, Liu Y, Noorbakhsh S, Niger M, Boeke M, Ueno D, Kalathil AN, Bao X, Li J, Shuch B, Bindra RS, Glazer PM. Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair. Nature Genetics 2018, 50: 1086-1092. PMID: 30013182, PMCID: PMC6072579, DOI: 10.1038/s41588-018-0170-4.
- Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In utero nanoparticle delivery for site-specific genome editing. Nature Communications 2018, 9: 2481. PMID: 29946143, PMCID: PMC6018676, DOI: 10.1038/s41467-018-04894-2.
- Turchick A, Hegan DC, Jensen RB, Glazer PM. A cell-penetrating antibody inhibits human RAD51 via direct binding. Nucleic Acids Research 2017, 45: 11782-11799. PMID: 29036688, PMCID: PMC5714174, DOI: 10.1093/nar/gkx871.
- Bindra R, Sulkowski P, Corso C, Glazer P, Shuch B. Induction of a BRCAness state by oncometabolites and exploitation by PARP inhibitors. Journal Of Clinical Oncology 2017, 35: 11586-11586. DOI: 10.1200/jco.2017.35.15_suppl.11586.
- Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Science Translational Medicine 2017, 9 PMID: 28148839, PMCID: PMC5435119, DOI: 10.1126/scitranslmed.aal2463.
- Lu Y, Glazer P. Regulation of DNA Repair by Hypoxia. 2016, 169-188. DOI: 10.1142/9789813147324_0007.
- Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Nature Communications 2016, 7: 13304. PMID: 27782131, PMCID: PMC5095181, DOI: 10.1038/ncomms13304.
- Glazer P, Gupta A, Liu Y, Quijano E, Saltzman W. Chemically Modified Gamma PNAs Targeting microRNA-210 as a Novel Anticancer Therapy With Specificity for Hypoxic Solid Tumors. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: e597. DOI: 10.1016/j.ijrobp.2016.06.2125.
- Bahal R, Gupta A, Glazer P. Precise Genome Modification Using Triplex Forming Oligonucleotides and Peptide Nucleic Acids. Advances In Experimental Medicine And Biology 2016, 93-110. DOI: 10.1007/978-1-4939-3509-3_6.
- Park S, Lee J, Platt J, Sweasy J, Glazer P, Herbst R, Koo J. E2F8 and its target genes as novel therapeutic targets for lung cancer. Journal Of Thoracic Oncology 2016, 11: s29. DOI: 10.1016/j.jtho.2015.12.048.
- Aneja S, Yu J, Glazer P. Genomic predictors of biochemical failure following radical prostatectomy. Journal Of Clinical Oncology 2016, 34: 114-114. DOI: 10.1200/jco.2016.34.2_suppl.114.
- Aneja S, Gross C, Glazer P, Yu J. Genomic Predictors of Biochemical Failure Following Radical Prostatectomy. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e251-e252. DOI: 10.1016/j.ijrobp.2015.07.1180.
- McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME. Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. Nature Communications 2015, 6: 6952. PMID: 25914116, PMCID: PMC4480796, DOI: 10.1038/ncomms7952.
- Engelman D, Cheng C, Bahal R, Babar I, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock D, Glazer P, Saltzman W, Slack F. pHLIP® Targeting and Delivery of PNA to Silence MicroRNA in Tumor Cells§. Biophysical Journal 2015, 108: 552a. DOI: 10.1016/j.bpj.2014.11.3029.
- Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature 2014, 518: 107-110. PMID: 25409146, PMCID: PMC4367962, DOI: 10.1038/nature13905.
- Engelman D, An M, Andreev O, Barrera F, Bahal R, Bosenberg M, Cheng C, Glazer P, Karabadzhak A, Reshetnyak Y, Saltzman W, Slack F, Svoronos A, Thevenin D. Imaging and Treating Tumors by Targeting their Acidity with Phlip, a Ph-Sensitve Insertion Peptide. Biophysical Journal 2014, 106: 231a. DOI: 10.1016/j.bpj.2013.11.1350.
- Scanlon S, Glazer P. Genetic Instability Induced by Hypoxic Stress. 2013, 151-181. DOI: 10.1007/978-1-4614-6280-4_8.
- Klein T, Glazer P, Xu T. Ras Promotes Nonautonomous Cell Death in Response to Radiation: Insights From a Novel Drosophila-based Model of Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s667. DOI: 10.1016/j.ijrobp.2012.07.1781.
- Decker R, Gettinger S, Glazer P, Wilson L. Vorinostat, a Histone Deacetylase Inhibitor, in Combination with Thoracic Radiotherapy in Advanced Non-small Cell Lung Cancer: A Dose Escalation Study. International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s574-s575. DOI: 10.1016/j.ijrobp.2011.06.1074.
- Rockwell S, Liu Y, Glazer P, Sartorelli A. Preclinical Studies of Onrigen in Combination with Radiation. International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s752. DOI: 10.1016/j.ijrobp.2011.06.1249.
- Glazer P. Mechanism of Radiosensitization by Inhibitors of Poly (ADP-Ribose) Polymerase (PARP). International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s87-s88. DOI: 10.1016/j.ijrobp.2010.07.234.
- Scanlon S, Hegan D, Sulkowski P, Glazer P. Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL -deficient human renal cell carcinoma. Oncotarget 2010, 5: 2-2. DOI: 10.18632/oncotarget.23445.
- Glazer P, Stachelek G, Dalal S, Sweasy J. Targeting Base Excision Repair to Potentiate Cancer Therapy. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s21. DOI: 10.1016/j.ijrobp.2009.07.071.
- Mani S, Moradi A, Abdolahi N, Martel M, Semnani S, Glazer P, Mani A. The Aberrant Expression of Beta-catenin in Esophageal Squamous Cell Cancer (ESCC) in Northeastern Iran. International Journal Of Radiation Oncology • Biology • Physics 2007, 69: s309-s310. DOI: 10.1016/j.ijrobp.2007.07.1366.
- Bindra R, Glazer P. Co-Repression of Mismatch Repair Gene Expression by Hypoxia in Cancer Cells: Role of the Myc/Max Network. International Journal Of Radiation Oncology • Biology • Physics 2007, 69: s613. DOI: 10.1016/j.ijrobp.2007.07.1928.
- Bindra R, Gibson S, Crosby M, Glazer P. 86 Complex Regulation of BRCA1 in Response to Hypoxic Stress. International Journal Of Radiation Oncology • Biology • Physics 2006, 66: s50. DOI: 10.1016/j.ijrobp.2006.07.116.
- Wang G, Glazer P. Peptide Nucleic Acids as Agents to Modify Target Gene Expression and Function. Medical Intelligence Unit 2006, 223-235. DOI: 10.1007/0-387-32956-0_14.
- Kuan J, Kole R, Nielsen P, Glazer P. 89. Gene Targeting of β_Globin IVS2 Using Sequence_Specific Peptide Nucleic Acids. Molecular Therapy 2006, 13: s37. DOI: 10.1016/j.ymthe.2006.08.107.
- Chin J, Lloyd J, Rogers F, Glazer P. 1030. Pyrazolo[3,4-d]Pyrimidine Guanine Base Substitution in Triplex Forming Oligonucleotides Improves Target Specificity and Chromosomal Mutagenesis. Molecular Therapy 2006, 13: s396. DOI: 10.1016/j.ymthe.2006.08.1125.
- Kalish J, Knauert M, Hegan D, Glazer P. 708. Gene Targeting with Triplex-Forming Oligonucletides in the Pyrimidine Motif. Molecular Therapy 2006, 13: s273-s274. DOI: 10.1016/j.ymthe.2006.08.787.
- Rogers F, Glazer P. 1031. Improved Intranuclear Delivery of PNA- Peptide Conjugates Designed for Chromosomal Gene Targeting. Molecular Therapy 2006, 13: s396. DOI: 10.1016/j.ymthe.2006.08.1126.
- Glazer P, Bindra R. Dysregulation of BRCAL in Hypoxia. International Journal Of Radiation Oncology • Biology • Physics 2005, 63: s145. DOI: 10.1016/j.ijrobp.2005.07.247.
- Bristow R, Meng A, Jalali F, Hedley D, Nichol T, Sweet J, Milosevic M, Bindra R, Glazer P. 67 Expression of DNA-dsb repair proteins is altered under hypoxia in prostate cancer cells. Radiotherapy And Oncology 2005, 76: s20-s21. DOI: 10.1016/s0167-8140(05)80228-2.
- Glazer P. Radical Nostalgia. 2005 DOI: 10.1017/9781580467001.
- Glazer P. Radical Nostalgia:. 2005 DOI: 10.2307/j.ctvc16p6r.
- Glazer P, Bindra R, Schaffer P, Bristow R, Hedley D. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. International Journal Of Radiation Oncology • Biology • Physics 2004, 60: s193. DOI: 10.1016/j.ijrobp.2004.06.131.
- GLAZER P, BINDRA R, SCHAFFER P, BRISTOW R, HEDLEY D. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. International Journal Of Radiation Oncology • Biology • Physics 2004, 60: s193-s193. DOI: 10.1016/s0360-3016(04)01188-5.
- Rogers F, Glazer P. Targeted Genome Modification Via Triple Helix Formation. Cancer Drug Discovery And Development 2004, 27-43. DOI: 10.1007/978-1-59259-777-2_3.
- Glazer P. Decreased expression of the DNA mismatch repair gene, Mlh1, under hypoxic stress in mammalian cells. International Journal Of Radiation Oncology • Biology • Physics 2003, 57: s143-s144. DOI: 10.1016/s0360-3016(03)00903-9.
- Wang G, Glazer P. Peptide nucleic acids as agents to modify target gene expression and function. International Journal Of Peptide Research And Therapeutics 2003, 10: 335-345. DOI: 10.1007/s10989-004-4903-0.
- Glazer P, Narayanan L, Liskay M, Campisi D. Over-expression of the DNA mismatch repair factor, PMS2, confers ionizing radiation resistance and hypermutability. International Journal Of Radiation Oncology • Biology • Physics 2002, 54: 51-52. DOI: 10.1016/s0360-3016(02)03145-0.
- Datta H, Glazer P. Intracellular generation of single-stranded DNA for chromosomal triplex formation and induced recombination. Nucleic Acids Research 2001, 29: 5140-5147. PMID: 11812847, PMCID: PMC97609, DOI: 10.1093/nar/29.24.5140.
- Glazer P, Peretz S, Jensen R, Gibson S. ATM-dependent expression of the IGF-I receptor in a pathway regulating radiation response. International Journal Of Radiation Oncology • Biology • Physics 2001, 51: 55. DOI: 10.1016/s0360-3016(01)01923-x.
- Knauert M, Glazer P. Triplex forming oligonucleotides: sequence-specific tools for gene targeting. Human Molecular Genetics 2001, 10: 2243-2251. PMID: 11673407, DOI: 10.1093/hmg/10.20.2243.
- Vasquez K, Dagle J, Weeks D, Glazer P. Chromosome Targeting at Short Polypurine Sites by Cationic Triplex-forming Oligonucleotides*. Journal Of Biological Chemistry 2001, 276: 38536-38541. PMID: 11504712, DOI: 10.1074/jbc.m101797200.
- Gorman L, Glazer P. Directed gene modification via triple helix formation. 2001, 1: 391-9. PMID: 11899085, DOI: 10.2174/1566524013363771.
- Xu X, Narayanan L, Dunklee B, Liskay R, Glazer P. Hypermutability to ionizing radiation in mismatch repair-deficient, Pms2 knockout mice. Cancer Research 2001, 61: 3775-80. PMID: 11325851.
- Datta H, Chan P, Vasquez K, Gupta R, Glazer P. Triplex-induced Recombination in Human Cell-free Extracts DEPENDENCE ON XPA AND HsRad51*. Journal Of Biological Chemistry 2001, 276: 18018-18023. PMID: 11278954, DOI: 10.1074/jbc.m011646200.
- Rockwell S, Yuan J, Peretz S, Glazer P. Genomic Instability in Cancer. Novartis Foundation Symposia 2001, 240: 133-151. PMID: 11727926, DOI: 10.1002/0470868716.ch9.
- Peretz S, Jensen R, Baserga R, Glazer P. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1676-1681. PMID: 11172010, PMCID: PMC29316, DOI: 10.1073/pnas.98.4.1676.
- Casey B, Glazer P. Gene targeting via triple-helix formation. Progress In Nucleic Acid Research And Molecular Biology 2001, 67: 163-192. PMID: 11525382, DOI: 10.1016/s0079-6603(01)67028-4.
- Vasquez K, Narayanan L, Glazer P. Specific Mutations Induced by Triplex-Forming Oligonucleotides in Mice. Science 2000, 290: 530-533. PMID: 11039937, DOI: 10.1126/science.290.5491.530.
- Zeng M, Narayanan L, Xu X, Prolla T, Liskay R, Glazer P. Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways. Cancer Research 2000, 60: 4889-93. PMID: 10987303.
- Luo Z, Macris M, Faruqi A, Glazer P. High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 9003-9008. PMID: 10900269, PMCID: PMC16811, DOI: 10.1073/pnas.160004997.
- Andrew S, Xu X, Baross-Francis A, Narayanan L, Milhausen K, Liskay R, Jirik F, Glazer P. Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis 2000, 21: 1291-1296. DOI: 10.1093/carcin/21.5.291.
- Turner B, Gumbs A, Carter D, Glazer P, Haffty B. Cyclin D1 expression and early breast cancer recurrence following lumpectomy and radiation. International Journal Of Radiation Oncology • Biology • Physics 2000, 47: 1169-1176. PMID: 10889369, DOI: 10.1016/s0360-3016(00)00525-3.
- Andrew S, Xu X, Baross-Francis A, Narayanan L, Milhausen K, Liskay R, Jirik F, Glazer P. Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis 2000, 21: 1291-1296. PMID: 10874005, DOI: 10.1093/carcin/21.7.1291.
- Glazer P. Better than the real thing: peptide nucleic acids Peptide Nucleic Acids: Protocols and Applications edited by Peter E. Nielsen and Michael Egholm. Trends In Genetics 2000, 16: 278. DOI: 10.1016/s0168-9525(00)01994-6.
- Turner B, Gumbs A, Carbone C, Carter D, Glazer P, Haffty B. Mutant p53 protein overexpression in women with ipsilateral breast tumor recurrence following lumpectomy and radiation therapy. Cancer 2000, 88: 1091-1098. PMID: 10699900, DOI: 10.1002/(sici)1097-0142(20000301)88:5<1091::aid-cncr21>3.0.co;2-y.
- Yoo S, Carter D, Turner B, Sasaki C, Son Y, Wilson L, Glazer P, Haffty B. Prognostic significance of cyclin D1 protein levels in early‐stage larynx cancer treated with primary radiation. International Journal Of Cancer 2000, 90: 22-28. PMID: 10725854, DOI: 10.1002/(sici)1097-0215(20000220)90:1<22::aid-ijc3>3.0.co;2-t.
- Faruqi A, Datta H, Carroll D, Seidman M, Glazer P. Triple-Helix Formation Induces Recombination in Mammalian Cells via a Nucleotide Excision Repair-Dependent Pathway. Molecular And Cellular Biology 2000, 20: 990-1000. PMID: 10629056, PMCID: PMC85216, DOI: 10.1128/mcb.20.3.990-1000.2000.
- Glazer P. DNA Repair Protocols: Eukaryotic Systems. Radiation Research 2000, 153: 241-242. DOI: 10.1667/0033-7587(2000)153[0241:drpes]2.0.co;2.
- Zeng M, Narayanan L, Glazer P. The influence of the DNA mismatch repair gene, Pms2, on the celluar response to ionizing radiation at low dose rates. International Journal Of Radiation Oncology • Biology • Physics 2000, 48: 287. DOI: 10.1016/s0360-3016(00)80376-4.
- Glazer P, Yuan J, Rockwell S, Narayanan L. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. International Journal Of Radiation Oncology • Biology • Physics 2000, 48: 288. DOI: 10.1016/s0360-3016(00)80378-8.
- Xu X, Glazer P, Wang G. Activation of human γ-globin gene expression via triplex-forming oligonucleotide (TFO)-directed mutations in the γ-globin gene 5′ flanking region. Gene 2000, 242: 219-228. PMID: 10721715, DOI: 10.1016/s0378-1119(99)00522-3.
- Turner B, Glazer P, Haffty B. BRCA1/BRCA2 in breast-conserving therapy. Journal Of Clinical Oncology 1999, 17: 3689. PMID: 10550169.
- Turner B, Harrold E, Matloff E, Smith T, Gumbs A, Beinfield M, Ward B, Skolnick M, Glazer P, Thomas A, Haffty B. BRCA1/BRCA2 germline mutations in locally recurrent breast cancer patients after lumpectomy and radiation therapy: implications for breast-conserving management in patients with BRCA1/BRCA2 mutations. Journal Of Clinical Oncology 1999, 17: 3017-24. PMID: 10506595, DOI: 10.1200/jco.1999.17.10.3017.
- Clairmont C, Narayanan L, Sun K, Glazer P, Sweasy J. The Tyr-265-to-Cys mutator mutant of DNA polymerase β induces a mutator phenotype in mouse LN12 cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 9580-9585. PMID: 10449735, PMCID: PMC22251, DOI: 10.1073/pnas.96.17.9580.
- Wang G, Xu X, Pace B, Dean D, Glazer P, Chan P, Goodman S, Shokolenko I. Peptide nucleic acid (PNA) binding-mediated induction of human γ-globin gene expression. Nucleic Acids Research 1999, 27: 2806-2813. PMID: 10373600, PMCID: PMC148492, DOI: 10.1093/nar/27.13.2806.
- Yao X, Buermeyer A, Narayanan L, Tran D, Baker S, Prolla T, Glazer P, Liskay R, Arnheim N. Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 6850-6855. PMID: 10359802, PMCID: PMC22005, DOI: 10.1073/pnas.96.12.6850.
- Chan P, Lin M, Faruqi A, Powell J, Seidman M, Glazer P. Targeted Correction of an Episomal Gene in Mammalian Cells by a Short DNA Fragment Tethered to a Triplex-forming Oligonucleotide*. Journal Of Biological Chemistry 1999, 274: 11541-11548. PMID: 10206960, DOI: 10.1074/jbc.274.17.11541.
- Vasquez K, Wang G, Havre P, Glazer P. Chromosomal mutations induced by triplex-forming oligonucleotides in mammalian cells. Nucleic Acids Research 1999, 27: 1176-1181. PMID: 9927753, PMCID: PMC148300, DOI: 10.1093/nar/27.4.1176.
- Lacroix L, Lacoste J, Reddoch J, Mergny J, Levy D, Seidman M, Matteucci M, Glazer P. Triplex Formation by Oligonucleotides Containing 5-(1-Propynyl)-2‘-deoxyuridine: Decreased Magnesium Dependence and Improved Intracellular Gene Targeting †. Biochemistry 1999, 38: 1893-1901. PMID: 10026270, DOI: 10.1021/bi982290q.
- Vasquez K, Glazer P. Genome Modification by Triplex-Forming Oligonucleotides. Perspectives In Antisense Science 1999, 2: 167-179. DOI: 10.1007/978-1-4615-5177-5_13.
- Zeng M, Narayanan L, Xu S, Liskay M, Glazer P. 154 Role of DNA mismatch repair in the cell response to ionizing radiation. International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 227. DOI: 10.1016/s0360-3016(99)90172-4.
- Turner B, Lehman T, Modali R, Carbone C, Bishop L, Curran W, Glazer P, Haffty B. 93 The germline p53 13964 gc mutation confers resistance to radiation in familial breast cancer patients. International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 195. DOI: 10.1016/s0360-3016(99)90111-6.
- Fritzell J, Glazer P, Haffty B, Gumbs A, Wang L, Carter D, Musgrove E, Curran W, Sutherland R, Turner B. 156 Cyclin D1 expression mediates sensitivity in ataxia telangiectasia and breast cancer. International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 228. DOI: 10.1016/s0360-3016(99)90174-8.
- Peretz S, Kim C, Rockwell S, Baserga R, Glazer P. 105 Tumor hypoxia induces and selects for overexpression of the igf-i receptor: Implications for tumor progression and radioresistance. International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 201. DOI: 10.1016/s0360-3016(99)90123-2.
- Turner B, Zhang J, Gumbs A, Maher M, Kaplan L, Carter D, Glazer P, Hurst H, Haffty B, Williams T. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Research 1998, 58: 5466-72. PMID: 9850080.
- Majumdar A, Khorlin A, Dyatkina N, Lin F, Powell J, Liu J, Fei Z, Khripine Y, Watanabe K, George J, Glazer P, Seidman M. Targeted gene knockout mediated by triple helix forming oligonucleotides. Nature Genetics 1998, 20: 212-214. PMID: 9771719, DOI: 10.1038/2530.
- Yuan J, Glazer P. Mutagenesis induced by the tumor microenvironment. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 1998, 400: 439-446. PMID: 9685702, DOI: 10.1016/s0027-5107(98)00042-6.
- Raha M, Lacroix L, Glazer P. Mutagenesis Mediated by Triple Helix–Forming Oligonucleotides Conjugated to Psoralen: Effects of Linker Arm Length and Sequence Context. Photochemistry And Photobiology 1998, 67: 289-294. PMID: 9523530, DOI: 10.1111/j.1751-1097.1998.tb05201.x.
- Faruqi A, Egholm M, Glazer P. Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 1398-1403. PMID: 9465026, PMCID: PMC19018, DOI: 10.1073/pnas.95.4.1398.
- Glazer P, Fritzell J, Narayanan L. Role of DNA mismatch repair in response to ionizing radiation. International Journal Of Radiation Oncology • Biology • Physics 1998, 42: 154. DOI: 10.1016/s0360-3016(98)80160-0.
- Turner B, Harrold E, Gumbs A, Matloff E, Ward B, Thomas A, Glazer P, Haffty B. Elevated frequency of germline BRCA1/BRCA2 gene mutations in locally recurrent breast cancer patients following lumpectomy and radiation therapy: Implications for breast conserving management in affected patients. International Journal Of Radiation Oncology • Biology • Physics 1998, 42: 179. DOI: 10.1016/s0360-3016(98)80210-1.
- Fritzell J, Narayanan L, Baker S, Bronner C, Andrew S, Prolla T, Bradley A, Jirik F, Liskay R, Glazer P. Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Research 1997, 57: 5143-7. PMID: 9371516.
- Segal D, Faruqi A, Glazer P, Carroll D. Processing of Targeted Psoralen Cross-Links in Xenopus Oocytes. Molecular And Cellular Biology 1997, 17: 6645-6652. PMID: 9343428, PMCID: PMC232518, DOI: 10.1128/mcb.17.11.6645.
- Chan P, Glazer P. Triplex DNA: fundamentals, advances, and potential applications for gene therapy. Journal Of Molecular Medicine 1997, 75: 267-282. PMID: 9151213, DOI: 10.1007/s001090050112.
- Narayanan L, Fritzell J, Baker S, Liskay R, Glazer P. Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 3122-3127. PMID: 9096356, PMCID: PMC20332, DOI: 10.1073/pnas.94.7.3122.
- Faruqi A, Krawczyk S, Matteucci M, Glazer P. Potassium-Resistant Triple Helix Formation and Improved Intracellular Gene Targeting by Oligodeoxyribonucleotides Containing 7-Deazaxanthine. Nucleic Acids Research 1997, 25: 633-640. PMID: 9016606, PMCID: PMC146453, DOI: 10.1093/nar/25.3.633.
- Glazer P, Reynolds T, Rockwell S. 23 Genetic instability induced by the tumor microenvironment. International Journal Of Radiation Oncology • Biology • Physics 1997, 39: 146. DOI: 10.1016/s0360-3016(97)80581-0.
- Turner B, Glazer P, Gumbs A, Kaplan L, Maher M, Hurst H, Carter D, Williams T, Haffty B. 1 The regulation of ipsilateral breast tumor recurrence after lumpectomy and radiation therapy by the transcription factors p53 and AP2. International Journal Of Radiation Oncology • Biology • Physics 1997, 39: 135. DOI: 10.1016/s0360-3016(97)80558-5.
- Gewirtz A, Stein C, Glazer P. Facilitating oligonucleotide delivery: helping antisense deliver on its promise. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 3161-3163. PMID: 8622906, PMCID: PMC39574, DOI: 10.1073/pnas.93.8.3161.
- Raha M, Wang G, Seidman M, Glazer P. Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: high frequency and altered spectrum in a xeroderma pigmentosum variant. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 2941-2946. PMID: 8610147, PMCID: PMC39739, DOI: 10.1073/pnas.93.7.2941.
- Golub E, Glazer P, Ward D, Radding C. RecA protein-mediated irreversible fixation of an oligodeoxyribonucleotide to specific site in DNA. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 1996, 351: 117-124. PMID: 8622705, DOI: 10.1016/0027-5107(95)00212-x.
- Wang G, Seidman M, Glazer P. Mutagenesis in Mammalian Cells Induced by Triple Helix Formation and Transcription-Coupled Repair. Science 1996, 271: 802-805. PMID: 8628995, DOI: 10.1126/science.271.5250.802.
- Gunther E, Havre P, Gasparro F, Glazer P. Triplex‐Mediated, in vitro Targeting of Psoralen Photoadducts within the Genome of a Transgenic Mouse. Photochemistry And Photobiology 1996, 63: 207-212. PMID: 8657733, DOI: 10.1111/j.1751-1097.1996.tb03015.x.
- Glazer P, Wang G, Havre P, Gunther E. Targeted Mutagenesis Mediated by the Triple Helix Formation. Methods In Molecular Biology 1996, 57: 109-118. PMID: 8849999, DOI: 10.1385/0-89603-332-5:109.
- Leach E, Gunther E, Yeasky T, Gibson L, Yang-Feng T, Glazer P. Frequent spontaneous deletions at a shuttle vector locus in transgenic mice. Mutagenesis 1996, 11: 49-56. PMID: 8671715, DOI: 10.1093/mutage/11.1.49.
- Turner B, Haffty B, Carter D, Gumbs A, Naryanan L, Baserga R, Glazer P. 41 Insulin growth factor-1 receptor (IGF-1R) expression as a prognostic indicator of local recurrence in conservatively treated breast cancer: A case-control study. International Journal Of Radiation Oncology • Biology • Physics 1996, 36: 179. DOI: 10.1016/s0360-3016(97)85382-5.
- Leach E, Narayanan L, Havre P, Gunther E, Yeasky T, Glazer P. Other transgenic mutation assays: Tissue specificity of spontaneous point mutations in λsupF transgenic mice. Environmental And Molecular Mutagenesis 1996, 28: 459-464. PMID: 8991078, DOI: 10.1002/(sici)1098-2280(1996)28:4<459::aid-em23>3.0.co;2-d.
- Yuan J, Yeasky T, Havre P, Glazer P. Induction of p53 in mouse cells decreases mutagenesis by UV radiation. Carcinogenesis 1995, 16: 2295-2300. PMID: 7586125, DOI: 10.1093/carcin/16.10.2295.
- Havre P, Yuan J, Hedrick L, Cho K, Glazer P. p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. Cancer Research 1995, 55: 4420-4. PMID: 7671255.
- Wang G, Glazer P. Altered Repair of Targeted Psoralen Photoadducts in the Context of an Oligonucleotide-mediated Triple Helix (∗). Journal Of Biological Chemistry 1995, 270: 22595-22601. PMID: 7673252, DOI: 10.1074/jbc.270.38.22595.
- Gunther E, Yeasky T, Gasparro F, Glazer P. Mutagenesis by 8-methoxypsoralen and 5-methylangelicin photoadducts in mouse fibroblasts: mutations at cross-linkable sites induced by offoadducts as well as cross-links. Cancer Research 1995, 55: 1283-8. PMID: 7882323.
- Yuan J, Yeasky T, Rhee M, Glazer P. Frequent T:A→G:C transversions in X-irradiated mouse cells. Carcinogenesis 1995, 16: 83-88. PMID: 7834808, DOI: 10.1093/carcin/16.1.83.
- Glazer P, Wang G, Seidman M, Levy D. 63 Oligonucleotide-mediated genetic manipulation: A new approach to gene therapy. International Journal Of Radiation Oncology • Biology • Physics 1995, 32: 172. DOI: 10.1016/0360-3016(95)97726-h.
- Gasparro F, Havre P, Olack G, Gunther E, Glazer P. Site-specific targeting of psoralen photoadducts with a triple helix-forming oligonucleotide: characterization of psoralen monoadduct and crosslink formation. Nucleic Acids Research 1994, 22: 2845-2852. PMID: 8052539, PMCID: PMC308256, DOI: 10.1093/nar/22.14.2845.
- Glazer P, Yuan J, Yeasky T, Rhee M. Distinctive spectrum of point mutations in x-ray treated mouse cells: Implications for DNA damage and repair pathways. International Journal Of Radiation Oncology • Biology • Physics 1994, 30: 237-238. DOI: 10.1016/0360-3016(94)90771-4.
- Havre P, Glazer P. Targeted mutagenesis of simian virus 40 DNA mediated by a triple helix-forming oligonucleotide. Journal Of Virology 1993, 67: 7324-31. PMID: 8230456, PMCID: PMC238196, DOI: 10.1128/jvi.67.12.7324-7331.1993.
- Gunther E, Murray N, Glazer P. High efficiency, restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA using a new E.coli lysogen. Nucleic Acids Research 1993, 21: 3903-3904. PMID: 8396240, PMCID: PMC309930, DOI: 10.1093/nar/21.16.3903.
- Summers W, Glazer P, Malkevich D. Lambda phage shuttle vectors for analysis of mutations in mammalian cells in culture and in transgenic mice. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 1989, 220: 263-268. PMID: 2522589, DOI: 10.1016/0165-1110(89)90030-4.
- Glazer P, Greggio N, Metherall J, Summers W. UV-induced DNA-binding proteins in human cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 1163-1167. PMID: 2919165, PMCID: PMC286646, DOI: 10.1073/pnas.86.4.1163.
- Summers W, Glazer P. Mismatch Repair in Mammalian Cells: Approaches to the in Vitro Study of DNA Mismatch Correction Reactions. NATO Science Series A: 1989, 255-261. DOI: 10.1007/978-1-4684-1327-4_24.
- Amplification and deregulation of MYC following Epstein-Barr virus infection of a human B-cell line.Lacy J, Summers W, Watson M, Glazer P, Summers W. Amplification and deregulation of MYC following Epstein-Barr virus infection of a human B-cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 1987, 84: 5838-5842. PMID: 3039510, PMCID: PMC298958, DOI: 10.1073/pnas.84.16.5838.
- Glazer P, Sarkar S, Chisholm G, Summers W. DNA Mismatch Repair Detected in Human Cell Extracts. Molecular And Cellular Biology 1987, 7: 218-224. DOI: 10.1128/mcb.7.1.218-224.1987.
- Glazer P, Sarkar S, Chisholm G, Summers W. DNA mismatch repair detected in human cell extracts. Molecular And Cellular Biology 1987, 7: 218-224. PMID: 3031461, PMCID: PMC365059, DOI: 10.1128/mcb.7.1.218.
- Glazer P, Sarkar S, Summers W. Detection and analysis of UV-induced mutations in mammalian cell DNA using a lambda phage shuttle vector. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 1041-1044. PMID: 2937054, PMCID: PMC323006, DOI: 10.1073/pnas.83.4.1041.
- Glazer P, Summers W. Oncogene Expression in Isogenic, EBV-Positive and -Negative Burkitt Lymphoma Cell Lines. Intervirology 1985, 23: 82-89. PMID: 2984143, DOI: 10.1159/000149589.
- Summers W, Sarkar S, Glazer P. Direct and inducible mutagenesis in mammalian cells. Cancer Surveys 1985, 4: 517-28. PMID: 3916654.
- GLAZER P, NEWELL P. Initiation of Aggregation by Dictyostelium discoideum in Mutant Populations Lacking Pulsatile Signalling. Microbiology 1981, 125: 221-232. DOI: 10.1099/00221287-125-2-221.
Biography
Radiation oncologist Peter M. Glazer, MD, PhD, is the chair of the Department of Therapeutic Radiology. He has dedicated his career to helping cancer patients receive the highest quality of care available in a supportive environment.
“When patients are undergoing radiotherapy for cancer, it can be a sensitive and challenging time for them and their families,” he says. “Our team does everything possible to keep our patients safe and comfortable throughout treatment.”
Dr. Glazer makes it his priority to provide patients seeking care at Smilow Cancer Hospital and its Care Centers with the most advanced technologies and evidence-based treatments. “We take great pride in giving our physicians the best tools to treat cancer,” he says.
As a professor of both therapeutic radiology and genetics at Yale School of Medicine, Dr. Glazer researches new therapeutic strategies for treating cancer and the role of altered DNA repair in tumor progression. His research was recently recognized by the National Cancer Institute of the NIH with a prestigious Outstanding Investigator Award of $7 million that will support his efforts to develop novel DNA repair inhibitors for cancer therapy.
Titles
- Robert E. Hunter Professor of Therapeutic Radiology and Professor of Genetics
- Chair, Therapeutic Radiology
Education & Training
- ResidentYale-New Haven Hospital (1991)
- PhDYale University (1987)
- MDYale University (1987)
- MScUniversity of Oxford, Biochemistry (1981)
- BAHarvard University, Chemistry (1979)
Additional Information
- Elected to the National Academy of Medicine 2022: National Academy of Medicine (2022)
- AB of Radiology, Radiation Oncology (1992)
- Gupta A, Barone C, Quijano E, Piotrowski-Daspit A, Perera J, Riccardi A, Jamali H, Turchick A, Zao W, Saltzman W, Glazer P, Egan M. Next generation triplex-forming PNAs for site-specific genome editing of the F508del CFTR mutation. Journal Of Cystic Fibrosis 2024 PMID: 39107154, DOI: 10.1016/j.jcf.2024.07.009.
- Carufe K, Economos N, Glazer P. Peptide Nucleic Acid-Mediated Regulation of CRISPR-Cas9 Specificity. Nucleic Acid Therapeutics 2024 PMID: 39037032, DOI: 10.1089/nat.2024.0007.
- Lynn A, Glazer P, Saltzman W, Stitelman D. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Current Stem Cell Reports 2024, 10: 30-36. DOI: 10.1007/s40778-024-00235-w.
- Altwerger G, Ghazarian M, Glazer P. Harnessing the effects of hypoxia-like inhibition on homology-directed DNA repair. Seminars In Cancer Biology 2023, 98: 11-18. PMID: 38029867, PMCID: PMC10872265, DOI: 10.1016/j.semcancer.2023.11.007.
- Zhang M, Zhao J, Glazer P, Bai W, Bepler G, Zhang X. Acetylation of MLH1 by CBP increases cellular DNA mismatch repair activity. The Journal Of Biochemistry 2023, 174: 183-191. PMID: 37094360, DOI: 10.1093/jb/mvad034.
- Takahashi T, Stoiljkovic M, Song E, Gao X, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu Z, Kristant A, Zhang Y, Sulkowski P, Glazer P, Kaczmarek L, Horvath T, Iwasaki A. Response to: Elevated L1 expression in ataxia telangiectasia likely explained by an RNA-seq batch effect. Neuron 2023, 111: 612-613. PMID: 36863323, DOI: 10.1016/j.neuron.2023.02.006.
- Putman R, Ricciardi A, Carufe K, Quijano E, Bahal R, Glazer P, Saltzman W. Nanoparticle‐mediated genome editing in single‐cell embryos via peptide nucleic acids. Bioengineering & Translational Medicine 2022, 8: e10458. PMID: 37206203, PMCID: PMC10189434, DOI: 10.1002/btm2.10458.
- Kim JW, McKay RR, Radke MR, Zhao S, Taplin ME, Davis NB, Monk P, Appleman LJ, Lara PN, Vaishampayan UN, Zhang J, Paul AK, Bubley G, Van Allen EM, Unlu S, Huang Y, Loda M, Shapiro GI, Glazer PM, LoRusso PM, Ivy SP, Shyr Y, Swisher EM, Petrylak DP. Randomized Trial of Olaparib With or Without Cediranib for Metastatic Castration-Resistant Prostate Cancer: The Results From National Cancer Institute 9984. Journal Of Clinical Oncology 2022, 41: 871-880. PMID: 36256912, PMCID: PMC9901975, DOI: 10.1200/jco.21.02947.
- Piotrowski-Daspit AS, Barone C, Lin CY, Deng Y, Wu D, Binns TC, Xu E, Ricciardi AS, Putman R, Garrison A, Nguyen R, Gupta A, Fan R, Glazer PM, Saltzman WM, Egan ME. In vivo correction of cystic fibrosis mediated by PNA nanoparticles. Science Advances 2022, 8: eabo0522. PMID: 36197984, PMCID: PMC9534507, DOI: 10.1126/sciadv.abo0522.
- Singh C, Bindra RS, Glazer PM, Vasquez JC, Pashankar F. Metastatic and multiply relapsed SDH‐deficient GIST and paraganglioma displays clinical response to combined poly ADP‐ribose polymerase inhibition and temozolomide. Pediatric Blood & Cancer 2022, 70: e30020. PMID: 36151992, DOI: 10.1002/pbc.30020.
- Takahashi T, Stoiljkovic M, Song E, Gao XB, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu ZW, Kristant A, Zhang Y, Sulkowski P, Glazer PM, Kaczmarek LK, Horvath TL, Iwasaki A. LINE-1 activation in the cerebellum drives ataxia. Neuron 2022, 110: 3278-3287.e8. PMID: 36070749, PMCID: PMC9588660, DOI: 10.1016/j.neuron.2022.08.011.
- Economos NG, Thapar U, Balasubramanian N, Karras GI, Glazer PM. An ELISA-based platform for rapid identification of structure-dependent nucleic acid–protein interactions detects novel DNA triplex interactors. Journal Of Biological Chemistry 2022, 298: 102398. PMID: 35988651, PMCID: PMC9493393, DOI: 10.1016/j.jbc.2022.102398.
- Economos NG, Quijano E, Carufe KEW, Perera JDR, Glazer PM. Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation. Nucleic Acids Research 2022, 50: e59-e59. PMID: 35235944, PMCID: PMC9177974, DOI: 10.1093/nar/gkac095.
- Dow J, Glazer P. Chapter 11 Oncometabolites, epigenetic marks, and DNA repair. 2022, 191-202. DOI: 10.1016/b978-0-323-91081-1.00008-x.
- Dow J, Krysztofiak A, Liu Y, Colon-Rios DA, Rogers FA, Glazer PM. Vulnerability of IDH1 mutant cancers to histone deacetylase inhibition via orthogonal suppression of DNA repair. Molecular Cancer Research 2021, 19: molcanres.mcr-21-0456-e.2021. PMID: 34535560, PMCID: PMC8642278, DOI: 10.1158/1541-7786.mcr-21-0456.
- Hayman TJ, Glazer PM. Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery. International Journal Of Molecular Sciences 2021, 22: 12761. PMID: 34884568, PMCID: PMC8657976, DOI: 10.3390/ijms222312761.
- Piotrowski-Daspit A, Bracaglia L, Barone C, Nguyen R, Glazer P, Egan M, Saltzman W. 582: In vivo nanoparticle-mediated therapeutic nucleic acid delivery for CF treatment. Journal Of Cystic Fibrosis 2021, 20: s277. DOI: 10.1016/s1569-1993(21)02005-1.
- Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Van Doorn J, Jones K, Moore H, Lopresti-Morrow L, Paradis T, Tylaska L, Zhang Q, Visca H, Reshetnyak YK, Andreev OA, Engelman DM, Glazer PM, Bindra RS, Paralkar VM. Correction to ‘Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity’. NAR Cancer 2021, 3: zcab047. PMID: 34888524, PMCID: PMC8651162, DOI: 10.1093/narcan/zcab047.
- Perera JDR, Carufe KEW, Glazer PM. Peptide nucleic acids and their role in gene regulation and editing. Biopolymers 2021, 112: e23460. PMID: 34129732, DOI: 10.1002/bip.23460.
- Raimundo L, Paterna A, Calheiros J, Ribeiro J, Cardoso DSP, Piga I, Neto SJ, Hegan D, Glazer PM, Indraccolo S, Mulhovo S, Costa JL, Ferreira M, Saraiva L. BBIT20 inhibits homologous DNA repair with disruption of the BRCA1–BARD1 interaction in breast and ovarian cancer. British Journal Of Pharmacology 2021, 178: 3627-3647. PMID: 33899955, PMCID: PMC9124438, DOI: 10.1111/bph.15506.
- Kim J, Cardin DB, Vaishampayan UN, Kato S, Grossman SR, Glazer P, Shyr Y, Ivy SP, LoRusso P. Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation. The Oncologist 2021, 26: e1104-e1109. PMID: 33742489, PMCID: PMC8265343, DOI: 10.1002/onco.13758.
- Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Van Doorn J, Jones K, Moore H, Lopresti-Morrow L, Paradis T, Tylaska L, Zhang Q, Visca H, Reshetnyak YK, Andreev OA, Engelman DM, Glazer PM, Bindra RS, Paralkar VM. Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity. NAR Cancer 2021, 3: zcab021. PMID: 34316708, PMCID: PMC8210154, DOI: 10.1093/narcan/zcab021.
- Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J. The NIH Somatic Cell Genome Editing program. Nature 2021, 592: 195-204. PMID: 33828315, PMCID: PMC8026397, DOI: 10.1038/s41586-021-03191-1.
- Dong YL, Vadla GP, Lu J, Ahmad V, Klein TJ, Liu LF, Glazer PM, Xu T, Chabu CY. Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance. Communications Biology 2021, 4: 374. PMID: 33742110, PMCID: PMC7979758, DOI: 10.1038/s42003-021-01898-5.
- Dharmaratne NU, Kaplan AR, Glazer PM. Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides. Cells 2021, 10: 541. PMID: 33806273, PMCID: PMC8000199, DOI: 10.3390/cells10030541.
- Eder JP, Doroshow DB, T. K, Keedy VL, Sklar JS, Glazer P, Bindra R, Shapiro GI. Clinical Efficacy of Olaparib in IDH1/IDH2-Mutant Mesenchymal Sarcomas. JCO Precision Oncology 2021, 5: 466-472. PMID: 34994649, PMCID: PMC9848565, DOI: 10.1200/po.20.00247.
- Ullrich SJ, Freedman-Weiss M, Ahle S, Mandl HK, Piotrowski-Daspit AS, Roberts K, Yung N, Maassel N, Bauer-Pisani T, Ricciardi AS, Egan ME, Glazer PM, Saltzman WM, Stitelman DH. Nanoparticles for delivery of agents to fetal lungs. Acta Biomaterialia 2021, 123: 346-353. PMID: 33484911, PMCID: PMC7962939, DOI: 10.1016/j.actbio.2021.01.024.
- Lu Y, Liu Y, Oeck S, Zhang GJ, Schramm A, Glazer PM. Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway. Cancer Research 2020, 80: 4655-4667. PMID: 32873635, PMCID: PMC7642024, DOI: 10.1158/0008-5472.can-20-1192.
- Sulkowski PL, Oeck S, Dow J, Economos NG, Mirfakhraie L, Liu Y, Noronha K, Bao X, Li J, Shuch BM, King MC, Bindra RS, Glazer PM. Oncometabolites suppress DNA repair by disrupting local chromatin signalling. Nature 2020, 582: 586-591. PMID: 32494005, PMCID: PMC7319896, DOI: 10.1038/s41586-020-2363-0.
- Kaplan AR, Pham H, Liu Y, Oyaghire S, Bahal R, Engelman DM, Glazer PM. Ku80-Targeted pH-Sensitive Peptide–PNA Conjugates Are Tumor Selective and Sensitize Cancer Cells to Ionizing Radiation. Molecular Cancer Research 2020, 18: 873-882. PMID: 32098827, PMCID: PMC7272299, DOI: 10.1158/1541-7786.mcr-19-0661.
- Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. Mitochondrial DNA stress signalling protects the nuclear genome. Nature Metabolism 2019, 1: 1209-1218. PMID: 32395698, PMCID: PMC7213273, DOI: 10.1038/s42255-019-0150-8.
- Kaplan AR, Glazer PM. Impact of hypoxia on DNA repair and genome integrity. Mutagenesis 2019, 35: 61-68. PMID: 31282537, PMCID: PMC7317153, DOI: 10.1093/mutage/gez019.
- Bindra R, Sundaram R, Aiello R, Marshall D, Bourassa P, Csengery J, Zhang Q, Robinson B, lopresti-Morrow L, Bechtold J, Tylaska L, Paradis T, Paralkar V, Hellsund P, Glazer P. Unlocking PARP inhibitor efficacy for HRD-negative cancers using the alphalex tumor targeting platform inhibitor efficacy for HRD-negative cancers using the alphalex tumor targeting platform. Journal Of Clinical Oncology 2019, 37: e14664-e14664. DOI: 10.1200/jco.2019.37.15_suppl.e14664.
- Kaplan AR, Gueble SE, Liu Y, Oeck S, Kim H, Yun Z, Glazer PM. Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51. Science Translational Medicine 2019, 11 PMID: 31092693, PMCID: PMC6626544, DOI: 10.1126/scitranslmed.aav4508.
- Piotrowski-Daspit AS, Glazer P, Saltzman WM. Debugging the genetic code: non-viral in vivo delivery of therapeutic genome editing technologies. Current Opinion In Biomedical Engineering 2018, 7: 24-32. PMID: 30984891, PMCID: PMC6456264, DOI: 10.1016/j.cobme.2018.08.002.
- Sulkowski PL, Scanlon SE, Oeck S, Glazer PM. PTEN Regulates Non-Homologous End Joining by Epigenetic Induction of NHEJ1/XLF. Molecular Cancer Research 2018, 16: molcanres.0581.2017. PMID: 29739874, PMCID: PMC6072556, DOI: 10.1158/1541-7786.mcr-17-0581.
- Sulkowski PL, Sundaram RK, Oeck S, Corso CD, Liu Y, Noorbakhsh S, Niger M, Boeke M, Ueno D, Kalathil AN, Bao X, Li J, Shuch B, Bindra RS, Glazer PM. Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair. Nature Genetics 2018, 50: 1086-1092. PMID: 30013182, PMCID: PMC6072579, DOI: 10.1038/s41588-018-0170-4.
- Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In utero nanoparticle delivery for site-specific genome editing. Nature Communications 2018, 9: 2481. PMID: 29946143, PMCID: PMC6018676, DOI: 10.1038/s41467-018-04894-2.
- Turchick A, Hegan DC, Jensen RB, Glazer PM. A cell-penetrating antibody inhibits human RAD51 via direct binding. Nucleic Acids Research 2017, 45: 11782-11799. PMID: 29036688, PMCID: PMC5714174, DOI: 10.1093/nar/gkx871.
- Bindra R, Sulkowski P, Corso C, Glazer P, Shuch B. Induction of a BRCAness state by oncometabolites and exploitation by PARP inhibitors. Journal Of Clinical Oncology 2017, 35: 11586-11586. DOI: 10.1200/jco.2017.35.15_suppl.11586.
- Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Science Translational Medicine 2017, 9 PMID: 28148839, PMCID: PMC5435119, DOI: 10.1126/scitranslmed.aal2463.
- Lu Y, Glazer P. Regulation of DNA Repair by Hypoxia. 2016, 169-188. DOI: 10.1142/9789813147324_0007.
- Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Nature Communications 2016, 7: 13304. PMID: 27782131, PMCID: PMC5095181, DOI: 10.1038/ncomms13304.
- Glazer P, Gupta A, Liu Y, Quijano E, Saltzman W. Chemically Modified Gamma PNAs Targeting microRNA-210 as a Novel Anticancer Therapy With Specificity for Hypoxic Solid Tumors. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: e597. DOI: 10.1016/j.ijrobp.2016.06.2125.
- Bahal R, Gupta A, Glazer P. Precise Genome Modification Using Triplex Forming Oligonucleotides and Peptide Nucleic Acids. Advances In Experimental Medicine And Biology 2016, 93-110. DOI: 10.1007/978-1-4939-3509-3_6.
- Park S, Lee J, Platt J, Sweasy J, Glazer P, Herbst R, Koo J. E2F8 and its target genes as novel therapeutic targets for lung cancer. Journal Of Thoracic Oncology 2016, 11: s29. DOI: 10.1016/j.jtho.2015.12.048.
- Aneja S, Yu J, Glazer P. Genomic predictors of biochemical failure following radical prostatectomy. Journal Of Clinical Oncology 2016, 34: 114-114. DOI: 10.1200/jco.2016.34.2_suppl.114.
- Aneja S, Gross C, Glazer P, Yu J. Genomic Predictors of Biochemical Failure Following Radical Prostatectomy. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e251-e252. DOI: 10.1016/j.ijrobp.2015.07.1180.
- McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME. Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. Nature Communications 2015, 6: 6952. PMID: 25914116, PMCID: PMC4480796, DOI: 10.1038/ncomms7952.
- Engelman D, Cheng C, Bahal R, Babar I, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock D, Glazer P, Saltzman W, Slack F. pHLIP® Targeting and Delivery of PNA to Silence MicroRNA in Tumor Cells§. Biophysical Journal 2015, 108: 552a. DOI: 10.1016/j.bpj.2014.11.3029.
- Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature 2014, 518: 107-110. PMID: 25409146, PMCID: PMC4367962, DOI: 10.1038/nature13905.
- Engelman D, An M, Andreev O, Barrera F, Bahal R, Bosenberg M, Cheng C, Glazer P, Karabadzhak A, Reshetnyak Y, Saltzman W, Slack F, Svoronos A, Thevenin D. Imaging and Treating Tumors by Targeting their Acidity with Phlip, a Ph-Sensitve Insertion Peptide. Biophysical Journal 2014, 106: 231a. DOI: 10.1016/j.bpj.2013.11.1350.
- Scanlon S, Glazer P. Genetic Instability Induced by Hypoxic Stress. 2013, 151-181. DOI: 10.1007/978-1-4614-6280-4_8.
- Klein T, Glazer P, Xu T. Ras Promotes Nonautonomous Cell Death in Response to Radiation: Insights From a Novel Drosophila-based Model of Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s667. DOI: 10.1016/j.ijrobp.2012.07.1781.
- Decker R, Gettinger S, Glazer P, Wilson L. Vorinostat, a Histone Deacetylase Inhibitor, in Combination with Thoracic Radiotherapy in Advanced Non-small Cell Lung Cancer: A Dose Escalation Study. International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s574-s575. DOI: 10.1016/j.ijrobp.2011.06.1074.
- Rockwell S, Liu Y, Glazer P, Sartorelli A. Preclinical Studies of Onrigen in Combination with Radiation. International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s752. DOI: 10.1016/j.ijrobp.2011.06.1249.
- Glazer P. Mechanism of Radiosensitization by Inhibitors of Poly (ADP-Ribose) Polymerase (PARP). International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s87-s88. DOI: 10.1016/j.ijrobp.2010.07.234.
- Scanlon S, Hegan D, Sulkowski P, Glazer P. Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL -deficient human renal cell carcinoma. Oncotarget 2010, 5: 2-2. DOI: 10.18632/oncotarget.23445.
- Glazer P, Stachelek G, Dalal S, Sweasy J. Targeting Base Excision Repair to Potentiate Cancer Therapy. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s21. DOI: 10.1016/j.ijrobp.2009.07.071.
- Mani S, Moradi A, Abdolahi N, Martel M, Semnani S, Glazer P, Mani A. The Aberrant Expression of Beta-catenin in Esophageal Squamous Cell Cancer (ESCC) in Northeastern Iran. International Journal Of Radiation Oncology • Biology • Physics 2007, 69: s309-s310. DOI: 10.1016/j.ijrobp.2007.07.1366.
- Bindra R, Glazer P. Co-Repression of Mismatch Repair Gene Expression by Hypoxia in Cancer Cells: Role of the Myc/Max Network. International Journal Of Radiation Oncology • Biology • Physics 2007, 69: s613. DOI: 10.1016/j.ijrobp.2007.07.1928.
- Bindra R, Gibson S, Crosby M, Glazer P. 86 Complex Regulation of BRCA1 in Response to Hypoxic Stress. International Journal Of Radiation Oncology • Biology • Physics 2006, 66: s50. DOI: 10.1016/j.ijrobp.2006.07.116.
- Wang G, Glazer P. Peptide Nucleic Acids as Agents to Modify Target Gene Expression and Function. Medical Intelligence Unit 2006, 223-235. DOI: 10.1007/0-387-32956-0_14.
- Kuan J, Kole R, Nielsen P, Glazer P. 89. Gene Targeting of β_Globin IVS2 Using Sequence_Specific Peptide Nucleic Acids. Molecular Therapy 2006, 13: s37. DOI: 10.1016/j.ymthe.2006.08.107.
- Chin J, Lloyd J, Rogers F, Glazer P. 1030. Pyrazolo[3,4-d]Pyrimidine Guanine Base Substitution in Triplex Forming Oligonucleotides Improves Target Specificity and Chromosomal Mutagenesis. Molecular Therapy 2006, 13: s396. DOI: 10.1016/j.ymthe.2006.08.1125.
- Kalish J, Knauert M, Hegan D, Glazer P. 708. Gene Targeting with Triplex-Forming Oligonucletides in the Pyrimidine Motif. Molecular Therapy 2006, 13: s273-s274. DOI: 10.1016/j.ymthe.2006.08.787.
- Rogers F, Glazer P. 1031. Improved Intranuclear Delivery of PNA- Peptide Conjugates Designed for Chromosomal Gene Targeting. Molecular Therapy 2006, 13: s396. DOI: 10.1016/j.ymthe.2006.08.1126.
- Glazer P, Bindra R. Dysregulation of BRCAL in Hypoxia. International Journal Of Radiation Oncology • Biology • Physics 2005, 63: s145. DOI: 10.1016/j.ijrobp.2005.07.247.
- Bristow R, Meng A, Jalali F, Hedley D, Nichol T, Sweet J, Milosevic M, Bindra R, Glazer P. 67 Expression of DNA-dsb repair proteins is altered under hypoxia in prostate cancer cells. Radiotherapy And Oncology 2005, 76: s20-s21. DOI: 10.1016/s0167-8140(05)80228-2.
- Glazer P. Radical Nostalgia. 2005 DOI: 10.1017/9781580467001.
- Glazer P. Radical Nostalgia:. 2005 DOI: 10.2307/j.ctvc16p6r.
- Glazer P, Bindra R, Schaffer P, Bristow R, Hedley D. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. International Journal Of Radiation Oncology • Biology • Physics 2004, 60: s193. DOI: 10.1016/j.ijrobp.2004.06.131.
- GLAZER P, BINDRA R, SCHAFFER P, BRISTOW R, HEDLEY D. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. International Journal Of Radiation Oncology • Biology • Physics 2004, 60: s193-s193. DOI: 10.1016/s0360-3016(04)01188-5.
- Rogers F, Glazer P. Targeted Genome Modification Via Triple Helix Formation. Cancer Drug Discovery And Development 2004, 27-43. DOI: 10.1007/978-1-59259-777-2_3.
- Glazer P. Decreased expression of the DNA mismatch repair gene, Mlh1, under hypoxic stress in mammalian cells. International Journal Of Radiation Oncology • Biology • Physics 2003, 57: s143-s144. DOI: 10.1016/s0360-3016(03)00903-9.
- Wang G, Glazer P. Peptide nucleic acids as agents to modify target gene expression and function. International Journal Of Peptide Research And Therapeutics 2003, 10: 335-345. DOI: 10.1007/s10989-004-4903-0.
- Glazer P, Narayanan L, Liskay M, Campisi D. Over-expression of the DNA mismatch repair factor, PMS2, confers ionizing radiation resistance and hypermutability. International Journal Of Radiation Oncology • Biology • Physics 2002, 54: 51-52. DOI: 10.1016/s0360-3016(02)03145-0.
- Datta H, Glazer P. Intracellular generation of single-stranded DNA for chromosomal triplex formation and induced recombination. Nucleic Acids Research 2001, 29: 5140-5147. PMID: 11812847, PMCID: PMC97609, DOI: 10.1093/nar/29.24.5140.
- Glazer P, Peretz S, Jensen R, Gibson S. ATM-dependent expression of the IGF-I receptor in a pathway regulating radiation response. International Journal Of Radiation Oncology • Biology • Physics 2001, 51: 55. DOI: 10.1016/s0360-3016(01)01923-x.
- Knauert M, Glazer P. Triplex forming oligonucleotides: sequence-specific tools for gene targeting. Human Molecular Genetics 2001, 10: 2243-2251. PMID: 11673407, DOI: 10.1093/hmg/10.20.2243.
- Vasquez K, Dagle J, Weeks D, Glazer P. Chromosome Targeting at Short Polypurine Sites by Cationic Triplex-forming Oligonucleotides*. Journal Of Biological Chemistry 2001, 276: 38536-38541. PMID: 11504712, DOI: 10.1074/jbc.m101797200.
- Gorman L, Glazer P. Directed gene modification via triple helix formation. 2001, 1: 391-9. PMID: 11899085, DOI: 10.2174/1566524013363771.
- Xu X, Narayanan L, Dunklee B, Liskay R, Glazer P. Hypermutability to ionizing radiation in mismatch repair-deficient, Pms2 knockout mice. Cancer Research 2001, 61: 3775-80. PMID: 11325851.
- Datta H, Chan P, Vasquez K, Gupta R, Glazer P. Triplex-induced Recombination in Human Cell-free Extracts DEPENDENCE ON XPA AND HsRad51*. Journal Of Biological Chemistry 2001, 276: 18018-18023. PMID: 11278954, DOI: 10.1074/jbc.m011646200.
- Rockwell S, Yuan J, Peretz S, Glazer P. Genomic Instability in Cancer. Novartis Foundation Symposia 2001, 240: 133-151. PMID: 11727926, DOI: 10.1002/0470868716.ch9.
- Peretz S, Jensen R, Baserga R, Glazer P. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1676-1681. PMID: 11172010, PMCID: PMC29316, DOI: 10.1073/pnas.98.4.1676.
- Casey B, Glazer P. Gene targeting via triple-helix formation. Progress In Nucleic Acid Research And Molecular Biology 2001, 67: 163-192. PMID: 11525382, DOI: 10.1016/s0079-6603(01)67028-4.
- Vasquez K, Narayanan L, Glazer P. Specific Mutations Induced by Triplex-Forming Oligonucleotides in Mice. Science 2000, 290: 530-533. PMID: 11039937, DOI: 10.1126/science.290.5491.530.
- Zeng M, Narayanan L, Xu X, Prolla T, Liskay R, Glazer P. Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways. Cancer Research 2000, 60: 4889-93. PMID: 10987303.
- Luo Z, Macris M, Faruqi A, Glazer P. High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 9003-9008. PMID: 10900269, PMCID: PMC16811, DOI: 10.1073/pnas.160004997.
- Andrew S, Xu X, Baross-Francis A, Narayanan L, Milhausen K, Liskay R, Jirik F, Glazer P. Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis 2000, 21: 1291-1296. DOI: 10.1093/carcin/21.5.291.
- Turner B, Gumbs A, Carter D, Glazer P, Haffty B. Cyclin D1 expression and early breast cancer recurrence following lumpectomy and radiation. International Journal Of Radiation Oncology • Biology • Physics 2000, 47: 1169-1176. PMID: 10889369, DOI: 10.1016/s0360-3016(00)00525-3.
- Andrew S, Xu X, Baross-Francis A, Narayanan L, Milhausen K, Liskay R, Jirik F, Glazer P. Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis 2000, 21: 1291-1296. PMID: 10874005, DOI: 10.1093/carcin/21.7.1291.
- Glazer P. Better than the real thing: peptide nucleic acids Peptide Nucleic Acids: Protocols and Applications edited by Peter E. Nielsen and Michael Egholm. Trends In Genetics 2000, 16: 278. DOI: 10.1016/s0168-9525(00)01994-6.
- Turner B, Gumbs A, Carbone C, Carter D, Glazer P, Haffty B. Mutant p53 protein overexpression in women with ipsilateral breast tumor recurrence following lumpectomy and radiation therapy. Cancer 2000, 88: 1091-1098. PMID: 10699900, DOI: 10.1002/(sici)1097-0142(20000301)88:5<1091::aid-cncr21>3.0.co;2-y.
- Yoo S, Carter D, Turner B, Sasaki C, Son Y, Wilson L, Glazer P, Haffty B. Prognostic significance of cyclin D1 protein levels in early‐stage larynx cancer treated with primary radiation. International Journal Of Cancer 2000, 90: 22-28. PMID: 10725854, DOI: 10.1002/(sici)1097-0215(20000220)90:1<22::aid-ijc3>3.0.co;2-t.
- Faruqi A, Datta H, Carroll D, Seidman M, Glazer P. Triple-Helix Formation Induces Recombination in Mammalian Cells via a Nucleotide Excision Repair-Dependent Pathway. Molecular And Cellular Biology 2000, 20: 990-1000. PMID: 10629056, PMCID: PMC85216, DOI: 10.1128/mcb.20.3.990-1000.2000.
- Glazer P. DNA Repair Protocols: Eukaryotic Systems. Radiation Research 2000, 153: 241-242. DOI: 10.1667/0033-7587(2000)153[0241:drpes]2.0.co;2.
- Zeng M, Narayanan L, Glazer P. The influence of the DNA mismatch repair gene, Pms2, on the celluar response to ionizing radiation at low dose rates. International Journal Of Radiation Oncology • Biology • Physics 2000, 48: 287. DOI: 10.1016/s0360-3016(00)80376-4.
- Glazer P, Yuan J, Rockwell S, Narayanan L. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. International Journal Of Radiation Oncology • Biology • Physics 2000, 48: 288. DOI: 10.1016/s0360-3016(00)80378-8.
- Xu X, Glazer P, Wang G. Activation of human γ-globin gene expression via triplex-forming oligonucleotide (TFO)-directed mutations in the γ-globin gene 5′ flanking region. Gene 2000, 242: 219-228. PMID: 10721715, DOI: 10.1016/s0378-1119(99)00522-3.
- Turner B, Glazer P, Haffty B. BRCA1/BRCA2 in breast-conserving therapy. Journal Of Clinical Oncology 1999, 17: 3689. PMID: 10550169.
- Turner B, Harrold E, Matloff E, Smith T, Gumbs A, Beinfield M, Ward B, Skolnick M, Glazer P, Thomas A, Haffty B. BRCA1/BRCA2 germline mutations in locally recurrent breast cancer patients after lumpectomy and radiation therapy: implications for breast-conserving management in patients with BRCA1/BRCA2 mutations. Journal Of Clinical Oncology 1999, 17: 3017-24. PMID: 10506595, DOI: 10.1200/jco.1999.17.10.3017.
- Clairmont C, Narayanan L, Sun K, Glazer P, Sweasy J. The Tyr-265-to-Cys mutator mutant of DNA polymerase β induces a mutator phenotype in mouse LN12 cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 9580-9585. PMID: 10449735, PMCID: PMC22251, DOI: 10.1073/pnas.96.17.9580.
- Wang G, Xu X, Pace B, Dean D, Glazer P, Chan P, Goodman S, Shokolenko I. Peptide nucleic acid (PNA) binding-mediated induction of human γ-globin gene expression. Nucleic Acids Research 1999, 27: 2806-2813. PMID: 10373600, PMCID: PMC148492, DOI: 10.1093/nar/27.13.2806.
- Yao X, Buermeyer A, Narayanan L, Tran D, Baker S, Prolla T, Glazer P, Liskay R, Arnheim N. Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 6850-6855. PMID: 10359802, PMCID: PMC22005, DOI: 10.1073/pnas.96.12.6850.
- Chan P, Lin M, Faruqi A, Powell J, Seidman M, Glazer P. Targeted Correction of an Episomal Gene in Mammalian Cells by a Short DNA Fragment Tethered to a Triplex-forming Oligonucleotide*. Journal Of Biological Chemistry 1999, 274: 11541-11548. PMID: 10206960, DOI: 10.1074/jbc.274.17.11541.
- Vasquez K, Wang G, Havre P, Glazer P. Chromosomal mutations induced by triplex-forming oligonucleotides in mammalian cells. Nucleic Acids Research 1999, 27: 1176-1181. PMID: 9927753, PMCID: PMC148300, DOI: 10.1093/nar/27.4.1176.
- Lacroix L, Lacoste J, Reddoch J, Mergny J, Levy D, Seidman M, Matteucci M, Glazer P. Triplex Formation by Oligonucleotides Containing 5-(1-Propynyl)-2‘-deoxyuridine: Decreased Magnesium Dependence and Improved Intracellular Gene Targeting †. Biochemistry 1999, 38: 1893-1901. PMID: 10026270, DOI: 10.1021/bi982290q.
- Vasquez K, Glazer P. Genome Modification by Triplex-Forming Oligonucleotides. Perspectives In Antisense Science 1999, 2: 167-179. DOI: 10.1007/978-1-4615-5177-5_13.
- Zeng M, Narayanan L, Xu S, Liskay M, Glazer P. 154 Role of DNA mismatch repair in the cell response to ionizing radiation. International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 227. DOI: 10.1016/s0360-3016(99)90172-4.
- Turner B, Lehman T, Modali R, Carbone C, Bishop L, Curran W, Glazer P, Haffty B. 93 The germline p53 13964 gc mutation confers resistance to radiation in familial breast cancer patients. International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 195. DOI: 10.1016/s0360-3016(99)90111-6.
- Fritzell J, Glazer P, Haffty B, Gumbs A, Wang L, Carter D, Musgrove E, Curran W, Sutherland R, Turner B. 156 Cyclin D1 expression mediates sensitivity in ataxia telangiectasia and breast cancer. International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 228. DOI: 10.1016/s0360-3016(99)90174-8.
- Peretz S, Kim C, Rockwell S, Baserga R, Glazer P. 105 Tumor hypoxia induces and selects for overexpression of the igf-i receptor: Implications for tumor progression and radioresistance. International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 201. DOI: 10.1016/s0360-3016(99)90123-2.
- Turner B, Zhang J, Gumbs A, Maher M, Kaplan L, Carter D, Glazer P, Hurst H, Haffty B, Williams T. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Research 1998, 58: 5466-72. PMID: 9850080.
- Majumdar A, Khorlin A, Dyatkina N, Lin F, Powell J, Liu J, Fei Z, Khripine Y, Watanabe K, George J, Glazer P, Seidman M. Targeted gene knockout mediated by triple helix forming oligonucleotides. Nature Genetics 1998, 20: 212-214. PMID: 9771719, DOI: 10.1038/2530.
- Yuan J, Glazer P. Mutagenesis induced by the tumor microenvironment. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 1998, 400: 439-446. PMID: 9685702, DOI: 10.1016/s0027-5107(98)00042-6.
- Raha M, Lacroix L, Glazer P. Mutagenesis Mediated by Triple Helix–Forming Oligonucleotides Conjugated to Psoralen: Effects of Linker Arm Length and Sequence Context. Photochemistry And Photobiology 1998, 67: 289-294. PMID: 9523530, DOI: 10.1111/j.1751-1097.1998.tb05201.x.
- Faruqi A, Egholm M, Glazer P. Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 1398-1403. PMID: 9465026, PMCID: PMC19018, DOI: 10.1073/pnas.95.4.1398.
- Glazer P, Fritzell J, Narayanan L. Role of DNA mismatch repair in response to ionizing radiation. International Journal Of Radiation Oncology • Biology • Physics 1998, 42: 154. DOI: 10.1016/s0360-3016(98)80160-0.
- Turner B, Harrold E, Gumbs A, Matloff E, Ward B, Thomas A, Glazer P, Haffty B. Elevated frequency of germline BRCA1/BRCA2 gene mutations in locally recurrent breast cancer patients following lumpectomy and radiation therapy: Implications for breast conserving management in affected patients. International Journal Of Radiation Oncology • Biology • Physics 1998, 42: 179. DOI: 10.1016/s0360-3016(98)80210-1.
- Fritzell J, Narayanan L, Baker S, Bronner C, Andrew S, Prolla T, Bradley A, Jirik F, Liskay R, Glazer P. Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Research 1997, 57: 5143-7. PMID: 9371516.
- Segal D, Faruqi A, Glazer P, Carroll D. Processing of Targeted Psoralen Cross-Links in Xenopus Oocytes. Molecular And Cellular Biology 1997, 17: 6645-6652. PMID: 9343428, PMCID: PMC232518, DOI: 10.1128/mcb.17.11.6645.
- Chan P, Glazer P. Triplex DNA: fundamentals, advances, and potential applications for gene therapy. Journal Of Molecular Medicine 1997, 75: 267-282. PMID: 9151213, DOI: 10.1007/s001090050112.
- Narayanan L, Fritzell J, Baker S, Liskay R, Glazer P. Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 3122-3127. PMID: 9096356, PMCID: PMC20332, DOI: 10.1073/pnas.94.7.3122.
- Faruqi A, Krawczyk S, Matteucci M, Glazer P. Potassium-Resistant Triple Helix Formation and Improved Intracellular Gene Targeting by Oligodeoxyribonucleotides Containing 7-Deazaxanthine. Nucleic Acids Research 1997, 25: 633-640. PMID: 9016606, PMCID: PMC146453, DOI: 10.1093/nar/25.3.633.
- Glazer P, Reynolds T, Rockwell S. 23 Genetic instability induced by the tumor microenvironment. International Journal Of Radiation Oncology • Biology • Physics 1997, 39: 146. DOI: 10.1016/s0360-3016(97)80581-0.
- Turner B, Glazer P, Gumbs A, Kaplan L, Maher M, Hurst H, Carter D, Williams T, Haffty B. 1 The regulation of ipsilateral breast tumor recurrence after lumpectomy and radiation therapy by the transcription factors p53 and AP2. International Journal Of Radiation Oncology • Biology • Physics 1997, 39: 135. DOI: 10.1016/s0360-3016(97)80558-5.
- Gewirtz A, Stein C, Glazer P. Facilitating oligonucleotide delivery: helping antisense deliver on its promise. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 3161-3163. PMID: 8622906, PMCID: PMC39574, DOI: 10.1073/pnas.93.8.3161.
- Raha M, Wang G, Seidman M, Glazer P. Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: high frequency and altered spectrum in a xeroderma pigmentosum variant. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 2941-2946. PMID: 8610147, PMCID: PMC39739, DOI: 10.1073/pnas.93.7.2941.
- Golub E, Glazer P, Ward D, Radding C. RecA protein-mediated irreversible fixation of an oligodeoxyribonucleotide to specific site in DNA. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 1996, 351: 117-124. PMID: 8622705, DOI: 10.1016/0027-5107(95)00212-x.
- Wang G, Seidman M, Glazer P. Mutagenesis in Mammalian Cells Induced by Triple Helix Formation and Transcription-Coupled Repair. Science 1996, 271: 802-805. PMID: 8628995, DOI: 10.1126/science.271.5250.802.
- Gunther E, Havre P, Gasparro F, Glazer P. Triplex‐Mediated, in vitro Targeting of Psoralen Photoadducts within the Genome of a Transgenic Mouse. Photochemistry And Photobiology 1996, 63: 207-212. PMID: 8657733, DOI: 10.1111/j.1751-1097.1996.tb03015.x.
- Glazer P, Wang G, Havre P, Gunther E. Targeted Mutagenesis Mediated by the Triple Helix Formation. Methods In Molecular Biology 1996, 57: 109-118. PMID: 8849999, DOI: 10.1385/0-89603-332-5:109.
- Leach E, Gunther E, Yeasky T, Gibson L, Yang-Feng T, Glazer P. Frequent spontaneous deletions at a shuttle vector locus in transgenic mice. Mutagenesis 1996, 11: 49-56. PMID: 8671715, DOI: 10.1093/mutage/11.1.49.
- Turner B, Haffty B, Carter D, Gumbs A, Naryanan L, Baserga R, Glazer P. 41 Insulin growth factor-1 receptor (IGF-1R) expression as a prognostic indicator of local recurrence in conservatively treated breast cancer: A case-control study. International Journal Of Radiation Oncology • Biology • Physics 1996, 36: 179. DOI: 10.1016/s0360-3016(97)85382-5.
- Leach E, Narayanan L, Havre P, Gunther E, Yeasky T, Glazer P. Other transgenic mutation assays: Tissue specificity of spontaneous point mutations in λsupF transgenic mice. Environmental And Molecular Mutagenesis 1996, 28: 459-464. PMID: 8991078, DOI: 10.1002/(sici)1098-2280(1996)28:4<459::aid-em23>3.0.co;2-d.
- Yuan J, Yeasky T, Havre P, Glazer P. Induction of p53 in mouse cells decreases mutagenesis by UV radiation. Carcinogenesis 1995, 16: 2295-2300. PMID: 7586125, DOI: 10.1093/carcin/16.10.2295.
- Havre P, Yuan J, Hedrick L, Cho K, Glazer P. p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. Cancer Research 1995, 55: 4420-4. PMID: 7671255.
- Wang G, Glazer P. Altered Repair of Targeted Psoralen Photoadducts in the Context of an Oligonucleotide-mediated Triple Helix (∗). Journal Of Biological Chemistry 1995, 270: 22595-22601. PMID: 7673252, DOI: 10.1074/jbc.270.38.22595.
- Gunther E, Yeasky T, Gasparro F, Glazer P. Mutagenesis by 8-methoxypsoralen and 5-methylangelicin photoadducts in mouse fibroblasts: mutations at cross-linkable sites induced by offoadducts as well as cross-links. Cancer Research 1995, 55: 1283-8. PMID: 7882323.
- Yuan J, Yeasky T, Rhee M, Glazer P. Frequent T:A→G:C transversions in X-irradiated mouse cells. Carcinogenesis 1995, 16: 83-88. PMID: 7834808, DOI: 10.1093/carcin/16.1.83.
- Glazer P, Wang G, Seidman M, Levy D. 63 Oligonucleotide-mediated genetic manipulation: A new approach to gene therapy. International Journal Of Radiation Oncology • Biology • Physics 1995, 32: 172. DOI: 10.1016/0360-3016(95)97726-h.
- Gasparro F, Havre P, Olack G, Gunther E, Glazer P. Site-specific targeting of psoralen photoadducts with a triple helix-forming oligonucleotide: characterization of psoralen monoadduct and crosslink formation. Nucleic Acids Research 1994, 22: 2845-2852. PMID: 8052539, PMCID: PMC308256, DOI: 10.1093/nar/22.14.2845.
- Glazer P, Yuan J, Yeasky T, Rhee M. Distinctive spectrum of point mutations in x-ray treated mouse cells: Implications for DNA damage and repair pathways. International Journal Of Radiation Oncology • Biology • Physics 1994, 30: 237-238. DOI: 10.1016/0360-3016(94)90771-4.
- Havre P, Glazer P. Targeted mutagenesis of simian virus 40 DNA mediated by a triple helix-forming oligonucleotide. Journal Of Virology 1993, 67: 7324-31. PMID: 8230456, PMCID: PMC238196, DOI: 10.1128/jvi.67.12.7324-7331.1993.
- Gunther E, Murray N, Glazer P. High efficiency, restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA using a new E.coli lysogen. Nucleic Acids Research 1993, 21: 3903-3904. PMID: 8396240, PMCID: PMC309930, DOI: 10.1093/nar/21.16.3903.
- Summers W, Glazer P, Malkevich D. Lambda phage shuttle vectors for analysis of mutations in mammalian cells in culture and in transgenic mice. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 1989, 220: 263-268. PMID: 2522589, DOI: 10.1016/0165-1110(89)90030-4.
- Glazer P, Greggio N, Metherall J, Summers W. UV-induced DNA-binding proteins in human cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 1163-1167. PMID: 2919165, PMCID: PMC286646, DOI: 10.1073/pnas.86.4.1163.
- Summers W, Glazer P. Mismatch Repair in Mammalian Cells: Approaches to the in Vitro Study of DNA Mismatch Correction Reactions. NATO Science Series A: 1989, 255-261. DOI: 10.1007/978-1-4684-1327-4_24.
- Amplification and deregulation of MYC following Epstein-Barr virus infection of a human B-cell line.Lacy J, Summers W, Watson M, Glazer P, Summers W. Amplification and deregulation of MYC following Epstein-Barr virus infection of a human B-cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 1987, 84: 5838-5842. PMID: 3039510, PMCID: PMC298958, DOI: 10.1073/pnas.84.16.5838.
- Glazer P, Sarkar S, Chisholm G, Summers W. DNA Mismatch Repair Detected in Human Cell Extracts. Molecular And Cellular Biology 1987, 7: 218-224. DOI: 10.1128/mcb.7.1.218-224.1987.
- Glazer P, Sarkar S, Chisholm G, Summers W. DNA mismatch repair detected in human cell extracts. Molecular And Cellular Biology 1987, 7: 218-224. PMID: 3031461, PMCID: PMC365059, DOI: 10.1128/mcb.7.1.218.
- Glazer P, Sarkar S, Summers W. Detection and analysis of UV-induced mutations in mammalian cell DNA using a lambda phage shuttle vector. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 1041-1044. PMID: 2937054, PMCID: PMC323006, DOI: 10.1073/pnas.83.4.1041.
- Glazer P, Summers W. Oncogene Expression in Isogenic, EBV-Positive and -Negative Burkitt Lymphoma Cell Lines. Intervirology 1985, 23: 82-89. PMID: 2984143, DOI: 10.1159/000149589.
- Summers W, Sarkar S, Glazer P. Direct and inducible mutagenesis in mammalian cells. Cancer Surveys 1985, 4: 517-28. PMID: 3916654.
- GLAZER P, NEWELL P. Initiation of Aggregation by Dictyostelium discoideum in Mutant Populations Lacking Pulsatile Signalling. Microbiology 1981, 125: 221-232. DOI: 10.1099/00221287-125-2-221.