- Yale Physicians Building800 Howard AvenueNew Haven, CT 06519
Matthew Williams, MD
Biography
Matthew Williams, MD, is a cardiac surgeon who serves as the surgical director of the Yale Medicine Structural Heart Disease Program, which cares for patients with valvular heart disease.
Dr. Williams subspecializes in valve disease and is an expert in both surgical treatment of valvular disease as well as transcatheter aortic valve replacements (TAVR), a minimally invasive procedure to replace failed valves; Yale Medicine has one of the highest-volume TAVR services in the country. Once reserved for patients who were very frail, had severe calcification in the aorta, or have had previous heart surgery, studies have shown it’s an option for a growing number of patients who don’t necessarily fall into those categories.
TAVR is also a unique area of cardiac care in that cardiologists and cardiac surgeons work together to provide patients with the best possible outcomes, Dr. Williams says.
Dr. Williams became a doctor because he wanted to help people, and he had always been fascinated by the heart. As a cardiac surgeon, he offers his patients the best individualized options for their particular situation. “It’s not a one-size-fits-all approach,” he says, and personalized care can make a difference. “The most serious valve disease leads to illness and death, but with the proper treatment you can often get people back to normal.”
Titles
- Associate Professor of Surgery (Cardiac)
Education & Training
- MDDuke University School of Medicine (1999)
Additional Information
- AB of Surgery, Thoracic & Cardiac Surgery (2011)
- Mori M, Bonnell L, Waldron C, Malaisrie C, Jacobs J, Kaneko T, Habib R, Williams M. Determinants of Retention of Early-Career Adult Cardiac Surgeons in the United States. Annals Of Thoracic Surgery Short Reports 2026 DOI: 10.1016/j.atssr.2026.04.013.
- Hassab A, Antonios J, Chou A, Williams M, Geirsson A, Vallabhajosyula P, Assi R. Contemporary Outcomes and Predictors of Adverse Events After Repair of Acute Type A Aortic Dissection: Report From an Aortic Center. Journal Of Cardiac Surgery 2025, 2025 DOI: 10.1155/jocs/6991973.
- Pitoulis F, Tauber K, Atluri P, Szeto W, Anwarruddin S, Kobayashi T, Desai N, Cevasco M, Bermudez C, Acker M, Williams M, Ibrahim M. The Challenges of Aortic Valve Management After Left Ventricular Assist Device Implantation. Annals Of Thoracic Surgery Short Reports 2024, 2: 567-572. PMID: 39790404, PMCID: PMC11708590, DOI: 10.1016/j.atssr.2024.04.028.
- Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.
- Iyengar A, Patrick W, Helmers M, Kelly J, Han J, Williams M, Mackay E, Desai N, Cevasco M. Neighborhood Socioeconomic Status Independently Predicts Outcomes After Mitral Valve Surgery. The Annals Of Thoracic Surgery 2023, 115: 940-947. PMID: 36623633, DOI: 10.1016/j.athoracsur.2023.01.002.
- Ibrahim M, Acker A, Weiss S, Lawrence K, Ottemiller S, McGarvey J, Epler M, Williams M, Szeto W, Acker M. Balancing quality and quaternary care imperative using a high-risk case review committee in adults. Interdisciplinary Cardiovascular And Thoracic Surgery 2022, 35: ivac268. PMID: 36315100, PMCID: PMC9651973, DOI: 10.1093/icvts/ivac268.
- Coronary Endarterectomy: Analysis of The Society of Thoracic Surgeons Adult Cardiac Surgery DatabaseKelly J, Han J, Desai N, Iyengar A, Acker A, Grau-Sepulveda M, Zwischenberger B, Jawitz O, Hargrove W, Szeto W, Williams M. Coronary Endarterectomy: Analysis of The Society of Thoracic Surgeons Adult Cardiac Surgery Database. The Annals Of Thoracic Surgery 2022, 114: 667-674. PMID: 35292259, DOI: 10.1016/j.athoracsur.2022.01.067.
- Shang M, Weininger G, Mori M, Kahler‐Quesada A, Degife E, Brooks C, Yousef S, Williams M, Assi R, Geirsson A, Vallabhajosyula P. Socioeconomic disparities in surveillance and follow‐up of patients with thoracic aortic aneurysm. Journal Of Cardiac Surgery 2021, 37: 831-839. PMID: 34873754, DOI: 10.1111/jocs.16173.
- Ibrahim M, Szeto W, Gutsche J, Weiss S, Bavaria J, Ottemiller S, Williams M, Gallagher J, Fishman N, Cunningham R, Brady L, Brennan P, Acker M. Transparency, Public Reporting, and a Culture of Change to Quality and Safety in Cardiac Surgery. The Annals Of Thoracic Surgery 2021, 114: 626-635. PMID: 34843698, DOI: 10.1016/j.athoracsur.2021.08.085.
- Patrick W, Iyengar A, Han J, Mays J, Helmers M, Kelly J, Wang X, Ghoreishi M, Taylor B, Atluri P, Desai N, Williams M. The learning curve of robotic coronary arterial bypass surgery: A report from the STS database. Journal Of Cardiac Surgery 2021, 36: 4178-4186. PMID: 34459029, PMCID: PMC9128069, DOI: 10.1111/jocs.15945.
- Ibrahim M, Acker M, Szeto W, Gutsche J, Williams M, Atluri P, Woods M, Richards T, Gardner T, McGarvey J, Epler M, Wald J, Rame E, Birati E, Bermudez C. Proposal for a trial of early left ventricular venting during venoarterial extracorporeal membrane oxygenation for cardiogenic shock. JTCVS Open 2021, 8: 393-400. PMID: 36004109, PMCID: PMC9390694, DOI: 10.1016/j.xjon.2021.07.024.
- Smood B, Spratt J, Mehaffey J, Luc J, Vinck E, Lehtinen M, Wallen T, Jenkinson C, Kim W, Kesieme E, Han J, Helmers M, Iyengar A, Patrick W, Kelly J, Watkins A, Cevasco M, Williams M. COVID‐19 and cardiothoracic surgery: Effects on training and workforce utilization in a global pandemic. Journal Of Cardiac Surgery 2021, 36: 3296-3305. PMID: 34173279, PMCID: PMC8447436, DOI: 10.1111/jocs.15773.
- Sperry A, Williams M, Atluri P, Szeto W, Cevasco M, Bermudez C, Acker M, Ibrahim M. The Surgeon’s Role in Cardiogenic Shock. Current Heart Failure Reports 2021, 18: 240-251. PMID: 33956313, DOI: 10.1007/s11897-021-00514-1.
- Han J, Mays J, Iyengar A, Luc J, Patrick W, Helmers M, Smood B, Kelly J, Williams M, Szeto W, Cevasco M. Wisdom From Past Presidents of The Society of Thoracic Surgeons. The Annals Of Thoracic Surgery 2021, 112: 1372-1377. PMID: 33905726, DOI: 10.1016/j.athoracsur.2021.04.031.
- Ibrahim M, Spelde A, Szeto W, Acker M, Atluri P, Grimm J, Cevasco M, Vallabhajosyula P, Bavaria J, Desai N, Williams M. Clinical and Echocardiographic Results of Aortic Valve Replacement in the Failing Ventricle: Do Aortic Stenosis and Aortic Regurgitation Differ? The Annals Of Thoracic Surgery 2021, 113: 853-858. PMID: 33631158, PMCID: PMC9774041, DOI: 10.1016/j.athoracsur.2021.02.016.
- Han J, Mays J, Sukhavasi A, Patrick W, Helmers M, Iyengar A, Smood B, Kelly J, Williams M, Szeto W, Cevasco M. Characteristics and Attitudes of Aspiring Cardiothoracic Surgeons: A Survey Study. The Annals Of Thoracic Surgery 2021, 112: 2063-2069. PMID: 33548275, DOI: 10.1016/j.athoracsur.2021.01.040.
- Ibrahim M, Spelde A, Gutsche J, Cevasco M, Bermudez C, Desai N, Szeto W, Atluri P, Acker M, Williams M. Coronary Artery Bypass Grafting in Cardiogenic Shock: Decision-Making, Management Options, and Outcomes. Journal Of Cardiothoracic And Vascular Anesthesia 2020, 35: 2144-2154. PMID: 33268279, DOI: 10.1053/j.jvca.2020.09.108.
- Patrick W, Bojko M, Han J, Kelly J, Iyengar A, Helmers M, Smood B, McCarthy F, Williams M. Neighborhood socioeconomic status is associated with differences in operative management and long-term survival after coronary artery bypass grafting. Journal Of Thoracic And Cardiovascular Surgery 2020, 164: 92-102.e8. PMID: 32977962, PMCID: PMC7959671, DOI: 10.1016/j.jtcvs.2020.08.024.
- Bojko MM, Habertheuer A, Bavaria JE, Suhail M, Hu RW, Harmon J, Desai ND, Milewski RK, Williams ML, Szeto WY, Mossey J, Vallabhajosyula P. Recurrent aortic insufficiency after emergency surgery for acute type A aortic dissection with aortic root preservation. Journal Of Thoracic And Cardiovascular Surgery 2020, 161: 1989-2000.e6. PMID: 32631661, DOI: 10.1016/j.jtcvs.2020.01.116.
- Bojko MM, Suhail M, Bavaria JE, Habertheuer A, Hu RW, Harmon J, Desai ND, Milewski RK, Williams ML, Szeto WY, Vallabhajosyula P. Fate of the Preserved Sinuses of Valsalva After Emergency Repair for Acute Type A Aortic Dissection. The Annals Of Thoracic Surgery 2020, 110: 1476-1483. PMID: 32156587, DOI: 10.1016/j.athoracsur.2020.01.083.
- Wang L, Williams M, Chen Y, Chen J. Novel Two-Phase Sampling Designs for Studying Binary Outcomes. Biometrics 2019, 76: 210-223. PMID: 31449330, PMCID: PMC7042058, DOI: 10.1111/biom.13140.
- Mehaffey J, Hawkins R, Charles E, Thibault D, Williams M, Brennan M, Thourani V, Badhwar V, Ailawadi G. Distressed communities are associated with worse outcomes after coronary artery bypass surgery. Journal Of Thoracic And Cardiovascular Surgery 2019, 160: 425-432.e9. PMID: 31543309, DOI: 10.1016/j.jtcvs.2019.06.104.
- Bhardwaj A, Miano T, Geller B, Milewski RC, Williams M, Bermudez C, Vallabhajosyula P, Patel P, Mackay E, Vernick W, Lane-Fall M, Raiten J, McDonald M, Haddle J, Gutsche J. Venovenous Extracorporeal Membrane Oxygenation for Patients With Return of Spontaneous Circulation After Cardiac Arrest Owing to Acute Respiratory Distress Syndrome. Journal Of Cardiothoracic And Vascular Anesthesia 2019, 33: 2216-2220. PMID: 31182376, DOI: 10.1053/j.jvca.2019.04.020.
- McCarthy F, Zhang L, Tam V, Chen J, Brown C, Patrick W, Hargrove W, Szeto W, Desai N, Wiebe D, Groeneveld P, Williams M. Geographically Derived Socioeconomic Factors to Improve Risk Prediction in Patients Having Aortic Valve Replacement. The American Journal Of Cardiology 2018, 123: 116-122. PMID: 30390990, PMCID: PMC6440469, DOI: 10.1016/j.amjcard.2018.09.019.
- Wallen TJ, Szeto W, Williams M, Atluri P, Arnaoutakis G, Fults M, Sultan I, Desai N, Acker M, Vallabhajosyula P. Tricuspid valve endocarditis in the era of the opioid epidemic. Journal Of Cardiac Surgery 2018, 33: 260-264. PMID: 29663522, DOI: 10.1111/jocs.13600.
- Cox M, Gulack B, Thibault D, He X, Williams M, Thourani V, Jacobs J, Brennan J, Daneshmand M, Acharya D. Outcomes after coronary artery bypass grafting in patients with myocardial infarction, cardiogenic shock and unresponsive neurological state: analysis of the Society of Thoracic Surgeons Database. European Journal Of Cardio-thoracic Surgery 2018, 54: 710-716. PMID: 29554232, PMCID: PMC13376260, DOI: 10.1093/ejcts/ezy114.
- McCarthy FH, Vemulapalli S, Li Z, Thourani V, Matsouaka RA, Desai ND, Kirtane A, Anwaruddin S, Williams ML, Giri J, Vallabhajosyula P, Li RH, Herrmann HC, Bavaria JE, Szeto WY. Association of Tricuspid Regurgitation With Transcatheter Aortic Valve Replacement Outcomes: A Report From The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. The Annals Of Thoracic Surgery 2018, 105: 1121-1128. PMID: 29502934, DOI: 10.1016/j.athoracsur.2017.11.018.
- Lee T, Kon Z, Cheema F, Grau‐Sepulveda M, Englum B, Kim S, Chaudhuri P, Thourani V, Ailawadi G, Hughes G, Williams M, Brennan J, Svensson L, Gammie J. Contemporary management and outcomes of acute type A aortic dissection: An analysis of the STS adult cardiac surgery database. Journal Of Cardiac Surgery 2018, 33: 7-18. PMID: 29314257, DOI: 10.1111/jocs.13511.
- Sultan I, Habertheuer A, Wallen T, Siki M, Szeto W, Bavaria JE, Williams M, Vallabhajosyula P. The role of extracorporeal membrane oxygenator therapy in the setting of Type A aortic dissection. Journal Of Cardiac Surgery 2017, 32: 822-825. PMID: 29216679, DOI: 10.1111/jocs.13245.
- Gutsche JT, Miano TA, Vernick W, Raiten J, Bermudez C, Vallabjoysula P, Milewski K, Szeto W, Fall ML, Williams ML, Patel P, Mikkelsen ME, Chiu C, Ramakrishna H, Canon J, Augoustides JG. Does a Mobile ECLS Program Reduce Mortality for Patients Transported for ECLS Therapy for Severe Acute Respiratory Failure? Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 1137-1141. PMID: 29153427, DOI: 10.1053/j.jvca.2017.08.050.
- Gutsche JT, Mikkelsen ME, McCarthy FH, Miano TA, Vernick WJ, Ramakrishna H, Patel PA, Augoustides Y, Szeto WY, Desai ND, Lane-Fall MB, Williams ML. In Response. Anesthesia & Analgesia 2017, 125: 706-707. PMID: 28654432, DOI: 10.1213/ane.0000000000002248.
- Gaffey A, Chen C, Chung J, Phillips E, Wald J, Williams M, Low D, Acker M, Atluri P. Improved Approach With Subcostal Exchange of the HeartMate II Left Ventricular Assist Device: Difference in On and Off Pump? The Annals Of Thoracic Surgery 2017, 104: 1540-1546. PMID: 28760470, DOI: 10.1016/j.athoracsur.2017.04.047.
- Kilic A, Arnaoutakis GJ, Bavaria JE, Sultan I, Desai ND, Vallabhajosyula P, Williams ML, Milewski RK, Szeto WY. Outcomes of Elective Aortic Hemiarch Reconstruction for Aneurysmal Disease in the Elderly. The Annals Of Thoracic Surgery 2017, 104: 1522-1530. PMID: 28648536, DOI: 10.1016/j.athoracsur.2017.03.067.
- Gutsche JT, Mikkelsen ME, McCarthy FH, Miano TA, Vernick WJ, Ramakrishna H, Patel PA, Augoustides Y, Szeto WY, Desai ND, Lane-Fall MB, Williams ML. Veno-Venous Extracorporeal Life Support in Hemodynamically Unstable Patients With ARDS. Anesthesia & Analgesia 2017, 124: 846-848. PMID: 27749338, PMCID: PMC5313331, DOI: 10.1213/ane.0000000000001646.
- Williams ML, Bavaria JE, Acker MA, Desai ND, Vallabhajosyula P, Hargrove WC, Atluri P, Szeto WY. Valve Selection in End-Stage Renal Disease: Should It Always Be Biological? The Annals Of Thoracic Surgery 2016, 102: 1531-1535. PMID: 27544289, DOI: 10.1016/j.athoracsur.2016.04.092.
- Arnaoutakis GJ, Vallabhajosyula P, Bavaria JE, Sultan I, Siki M, Naidu S, Milewski RK, Williams ML, Hargrove WC, Desai ND, Szeto WY. The Impact of Deep Versus Moderate Hypothermia on Postoperative Kidney Function After Elective Aortic Hemiarch Repair. The Annals Of Thoracic Surgery 2016, 102: 1313-1321. PMID: 27318775, DOI: 10.1016/j.athoracsur.2016.04.007.
- McCarthy FH, Bavaria JE, McDermott KM, Moeller P, Spragan D, Hoedt A, Dibble T, Savino D, Williams ML, Vallabhajosyula P, Szeto WY, Desai ND. At the Root of the Repair Debate: Outcomes After Elective Aortic Root Replacements for Aortic Insufficiency With Aneurysm. The Annals Of Thoracic Surgery 2016, 102: 1199-1205. PMID: 27261085, DOI: 10.1016/j.athoracsur.2016.03.071.
- Schumer E, Chaney J, Trivedi J, Linsky P, Williams M, Slaughter M. Emergency Coronary Artery Bypass Grafting: Indications and Outcomes from 2003 through 2013. Texas Heart Institute Journal 2016, 43: 214-9. PMID: 27303236, PMCID: PMC4894699, DOI: 10.14503/thij-14-4978.
- Vallabhajosyula P, Kramer M, Lazar S, McCarthy F, Rame E, Wald J, Szeto W, Williams M, Atluri P, Desai N, Acker M. Lower-extremity complications with femoral extracorporeal life support. Journal Of Thoracic And Cardiovascular Surgery 2016, 151: 1738-1744. PMID: 27207130, DOI: 10.1016/j.jtcvs.2015.11.044.
- Acharya D, Gulack B, Loyaga-Rendon R, Davies J, He X, Brennan J, Thourani V, Williams M. Clinical Characteristics and Outcomes of Patients With Myocardial Infarction and Cardiogenic Shock Undergoing Coronary Artery Bypass Surgery: Data From The Society of Thoracic Surgeons National Database. The Annals Of Thoracic Surgery 2015, 101: 558-566. PMID: 26718859, PMCID: PMC5142520, DOI: 10.1016/j.athoracsur.2015.10.051.
- Jassar AS, Vallabhajosyula P, Bavaria JE, Gutsche J, Desai ND, Williams ML, Milewski RK, Hargrove WC, Szeto WY. Direct innominate artery cannulation: An alternate technique for antegrade cerebral perfusion during aortic hemiarch reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2015, 151: 1073-1078. PMID: 26725716, DOI: 10.1016/j.jtcvs.2015.11.027.
- Trivedi J, Cheng A, Singh R, Williams M, Slaughter M. Survival on the Heart Transplant Waiting List: Impact of Continuous Flow Left Ventricular Assist Device as Bridge to Transplant. The Annals Of Thoracic Surgery 2014, 98: 830-834. PMID: 25087934, DOI: 10.1016/j.athoracsur.2014.05.019.
- Andersen N, Brennan J, Zhao Y, Williams J, Williams M, Smith P, Scarborough J, Hughes G. Insurance Status Is Associated With Acuity of Presentation and Outcomes for Thoracic Aortic Operations. Circulation Population Health And Outcomes 2014, 7: 398-406. PMID: 24714600, PMCID: PMC4031288, DOI: 10.1161/circoutcomes.113.000593.
- Vassileva C, Li S, Thourani V, Suri R, Williams M, Lee R, Rankin J. Outcome Characteristics of Multiple-Valve Surgery. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 27-32. PMID: 24402042, DOI: 10.1097/imi.0000000000000028.
- Vassileva C, Li S, Thourani V, Suri R, Williams M, Lee R, Rankin J. Outcome Characteristics of Multiple-Valve Surgery. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 27-32. DOI: 10.1177/155698451400900105.
- Pagni S, Ganzel B, Singh R, Austin E, Mascio C, Williams M, Akella P, Trivedi J. Clinical Outcome After Triple-Valve Operations in the Modern Era: Are Elderly Patients at Increased Surgical Risk? The Annals Of Thoracic Surgery 2013, 97: 569-576. PMID: 24140216, DOI: 10.1016/j.athoracsur.2013.07.083.
- Williams M, He X, Rankin J, Slaughter M, Gammie J. Preoperative Hematocrit Is a Powerful Predictor of Adverse Outcomes in Coronary Artery Bypass Graft Surgery: A Report From The Society of Thoracic Surgeons Adult Cardiac Surgery Database. The Annals Of Thoracic Surgery 2013, 96: 1628-1634. PMID: 24055236, DOI: 10.1016/j.athoracsur.2013.06.030.
- Gaca J, Sheng S, Daneshmand M, Rankin J, Williams M, O'Brien S, Gammie J. Current Outcomes for Tricuspid Valve Infective Endocarditis Surgery in North America. The Annals Of Thoracic Surgery 2013, 96: 1374-1381. PMID: 23968767, DOI: 10.1016/j.athoracsur.2013.05.046.
- Pagni S, Ganzel B, Trivedi J, Singh R, Mascio C, Austin E, Slaughter M, Williams M. Early and Midterm Outcomes Following Surgery for Acute Type A Aortic Dissection. Journal Of Cardiac Surgery 2013, 28: 543-549. PMID: 23909254, DOI: 10.1111/jocs.12170.
- Trivedi J, Sobieski M, Schwartz S, Williams M, Slaughter M. Novel Thrombosis Risk Index as Predictor of Left Ventricular Assist Device Thrombosis. ASAIO Journal 2013, 59: 380-383. PMID: 23820276, DOI: 10.1097/mat.0b013e318291d0c1.
- Keeling W, Williams M, Slaughter M, Zhao Y, Puskas J. Off-Pump and On-Pump Coronary Revascularization in Patients With Low Ejection Fraction: A Report From The Society of Thoracic Surgeons National Database. The Annals Of Thoracic Surgery 2013, 96: 83-89. PMID: 23743061, DOI: 10.1016/j.athoracsur.2013.03.098.
- Rankin J, Thourani V, Suri R, He X, O'Brien S, Vassileva C, Shah A, Williams M. Associations between valve repair and reduced operative mortality in 21 056 mitral/tricuspid double valve procedures†. European Journal Of Cardio-thoracic Surgery 2013, 44: 472-477. PMID: 23515166, DOI: 10.1093/ejcts/ezt077.
- Cannon R, Trivedi J, Pagni S, Dwivedi A, Bland J, Slaughter M, Ross C, Richardson J, Williams M. Open Repair of Blunt Thoracic Aortic Injury Remains Relevant in the Endovascular Era. Journal Of The American College Of Surgeons 2012, 214: 943-949. PMID: 22541985, DOI: 10.1016/j.jamcollsurg.2012.03.003.
- Williams M, Ganzel B, Slater A, Slaughter M, Trivedi J, Edmonds H, Pagni S. Antegrade versus Retrograde Cerebral Protection in Repair of Acute Ascending Aortic Dissection. The American Surgeon 2012, 78: 349-351. PMID: 22524776, DOI: 10.1177/000313481207800346.
- Pagni S, Slater A, Trivedi J, Williams M, Austin E, Mascio C, Ganzel B. Proximal Thoracic Aortic Replacement for Aneurysmal Disease Using the Freestyle Stentless Bioprosthesis: A 10-Year Experience. The Annals Of Thoracic Surgery 2011, 92: 873-879. PMID: 21871272, DOI: 10.1016/j.athoracsur.2011.04.093.
- Pagni S, Trivedi J, Ganzel B, Williams M, Kapoor N, Ross C, Slater A. Thoracic Aortic Mobile Thrombus: Is There a Role for Early Surgical Intervention? The Annals Of Thoracic Surgery 2011, 91: 1875-1881. PMID: 21529769, DOI: 10.1016/j.athoracsur.2011.02.011.
- Piacentino V, Williams M, Depp T, Garcia-Huerta K, Blue L, Lodge A, Mackensen G, Swaminathan M, Rogers J, Milano C. Impact of Tricuspid Valve Regurgitation in Patients Treated With Implantable Left Ventricular Assist Devices. The Annals Of Thoracic Surgery 2011, 91: 1342-1347. PMID: 21457940, DOI: 10.1016/j.athoracsur.2011.01.053.
- Williams M, Trivedi J, McCants K, Prabhu S, Birks E, Oliver L, Slaughter M. Heart Transplant vs Left Ventricular Assist Device in Heart Transplant-Eligible Patients. The Annals Of Thoracic Surgery 2011, 91: 1330-1334. PMID: 21439545, DOI: 10.1016/j.athoracsur.2011.01.062.
- Williams M, Trivedi J, Doughtie C, Slaughter M. Is Female Sex an Independent Risk Factor for Perioperative Transfusion in Coronary Artery Bypass Graft Surgery? Journal Of The American College Of Surgeons 2011, 212: 362-366. PMID: 21356488, DOI: 10.1016/j.jamcollsurg.2010.12.008.
- Williams M, Sheng S, Gammie J, Rankin J, Smith P, Hughes G. Aortic Dissection as a Complication of Cardiac Surgery: Report From The Society of Thoracic Surgeons Database. The Annals Of Thoracic Surgery 2010, 90: 1812-1817. PMID: 21095316, DOI: 10.1016/j.athoracsur.2010.05.023.
- Lee M, Kozitza R, Mudrick D, Williams M, Lodge A, Harrison J, Glower D. Intraoperative Device Closure of Postinfarction Ventricular Septal Defects. The Annals Of Thoracic Surgery 2010, 89: e48-e50. PMID: 20494012, DOI: 10.1016/j.athoracsur.2010.03.081.
- Williams M, Wechsler S, Hughes G. Two‐Stage Total Aortic Replacement for Loeys–Dietz Syndrome. Journal Of Cardiac Surgery 2010, 25: 223-224. PMID: 20492031, DOI: 10.1111/j.1540-8191.2009.00956.x.
- Williams M, Wechsler S, Hughes G. Two‐Stage Total Aortic Replacement for Loeys–Dietz Syndrome. Journal Of Cardiac Surgery 2010 PMID: 20070434, DOI: 10.1111/j.1540-8191.2010.00956.x.
- Williams M, Daneshmand M, Jollis J, Horton J, Shaw L, Swaminathan M, Davis R, Glower D, Smith P, Milano C. Mitral Gradients and Frequency of Recurrence of Mitral Regurgitation After Ring Annuloplasty for Ischemic Mitral Regurgitation. The Annals Of Thoracic Surgery 2009, 88: 1197-1201. PMID: 19766807, DOI: 10.1016/j.athoracsur.2009.06.022.
- Milano C, Daneshmand M, Rankin J, Honeycutt E, Williams M, Swaminathan M, Linblad L, Shaw L, Glower D, Smith P. Survival Prognosis and Surgical Management of Ischemic Mitral Regurgitation. The Annals Of Thoracic Surgery 2008, 86: 735-744. PMID: 18721554, DOI: 10.1016/j.athoracsur.2008.05.017.
- Hata J, Williams M, Schroder J, Lima B, Keys J, Blaxall B, Petrofski J, Jakoi A, Milano C, Koch W. Lymphocyte Levels of GRK2 (βARK1) Mirror Changes in the LVAD-Supported Failing Human Heart: Lower GRK2 Associated With Improved β-Adrenergic Signaling After Mechanical Unloading. Journal Of Cardiac Failure 2006, 12: 360-368. PMID: 16762799, DOI: 10.1016/j.cardfail.2006.02.011.
- Petrofski J, Hata J, Williams M, Parsa C, Thompson R, Hanish S, Gehrig T, Koch W, Milano C. A Gβγ inhibitor reduces intimal hyperplasia in aortocoronary saphenous vein grafts. Journal Of Thoracic And Cardiovascular Surgery 2005, 130: 1683-1690. PMID: 16308016, DOI: 10.1016/j.jtcvs.2005.01.024.
- Schroder J, Williams M, Hata J, Muhlbaier L, Swaminathan M, Mathew J, Glower D, O’Connor C, Smith P, Milano C. Impact of Mitral Valve Regurgitation Evaluated by Intraoperative Transesophageal Echocardiography on Long-Term Outcomes After Coronary Artery Bypass Grafting. Circulation 2005, 112: i293-8. PMID: 16159834, DOI: 10.1161/circulationaha.104.523472.
- Williams M, Muhlbaier L, Schroder J, Hata J, Peterson E, Smith P, Landolfo K, Messier R, Davis R, Milano C. Risk-Adjusted Short- and Long-Term Outcomes for On-Pump Versus Off-Pump Coronary Artery Bypass Surgery. Circulation 2005, 112: i366-70. PMID: 16159847, DOI: 10.1161/circulationaha.104.526012.
- Hata J, Petrofski J, Schroder J, Williams M, Timberlake S, Pippen A, Corwin M, Solan A, Jakoi A, Gehrig T, Kontos C, Milano C. Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts. Journal Of Thoracic And Cardiovascular Surgery 2005, 129: 1405-1413. PMID: 15942585, DOI: 10.1016/j.jtcvs.2004.11.048.
- Most P, Pleger S, Völkers M, Heidt B, Boerries M, Weichenhan D, Löffler E, Janssen P, Eckhart A, Martini J, Williams M, Katus H, Remppis A, Koch W. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. Journal Of Clinical Investigation 2004, 114: 1550-1563. PMID: 15578088, PMCID: PMC529280, DOI: 10.1172/jci21454.
- Hata J, Williams M, Koch W. Genetic manipulation of myocardial β-adrenergic receptor activation and desensitization. Journal Of Molecular And Cellular Cardiology 2004, 37: 11-21. PMID: 15242731, DOI: 10.1016/j.yjmcc.2004.03.014.
- Williams M, Rampersaud E, Wolfe W. A man with saphenous vein graft aneurysms after bypass surgery. The Annals Of Thoracic Surgery 2004, 77: 1815-1817. PMID: 15111195, DOI: 10.1016/s0003-4975(03)01144-5.
- Williams M, Hata J, Schroder J, Rampersaud E, Petrofski J, Jakoi A, Milano C, Koch W. Targeted β-Adrenergic Receptor Kinase (βARK1) Inhibition by Gene Transfer in Failing Human Hearts. Circulation 2004, 109: 1590-1593. PMID: 15051637, DOI: 10.1161/01.cir.0000125521.40985.28.
- Williams M, Koch W. Viral-Based Myocardial Gene Therapy Approaches to Alter Cardiac Function. Annual Review Of Physiology 2004, 66: 49-75. PMID: 14977396, DOI: 10.1146/annurev.physiol.66.032102.141555.
- Petrofski J, Hata J, Gehrig T, Hanish S, Williams M, Thompson R, Parsa C, Koch W, Milano C. Gene delivery to aortocoronary saphenous vein grafts in a large animal model of intimal hyperplasia. Journal Of Thoracic And Cardiovascular Surgery 2004, 127: 27-33. PMID: 14752409, DOI: 10.1016/j.jtcvs.2003.07.032.
- Yale Physicians Building800 Howard AvenueNew Haven, CT 06519
Biography
Matthew Williams, MD, is a cardiac surgeon who serves as the surgical director of the Yale Medicine Structural Heart Disease Program, which cares for patients with valvular heart disease.
Dr. Williams subspecializes in valve disease and is an expert in both surgical treatment of valvular disease as well as transcatheter aortic valve replacements (TAVR), a minimally invasive procedure to replace failed valves; Yale Medicine has one of the highest-volume TAVR services in the country. Once reserved for patients who were very frail, had severe calcification in the aorta, or have had previous heart surgery, studies have shown it’s an option for a growing number of patients who don’t necessarily fall into those categories.
TAVR is also a unique area of cardiac care in that cardiologists and cardiac surgeons work together to provide patients with the best possible outcomes, Dr. Williams says.
Dr. Williams became a doctor because he wanted to help people, and he had always been fascinated by the heart. As a cardiac surgeon, he offers his patients the best individualized options for their particular situation. “It’s not a one-size-fits-all approach,” he says, and personalized care can make a difference. “The most serious valve disease leads to illness and death, but with the proper treatment you can often get people back to normal.”
Titles
- Associate Professor of Surgery (Cardiac)
Education & Training
- MDDuke University School of Medicine (1999)
Additional Information
- AB of Surgery, Thoracic & Cardiac Surgery (2011)
- Mori M, Bonnell L, Waldron C, Malaisrie C, Jacobs J, Kaneko T, Habib R, Williams M. Determinants of Retention of Early-Career Adult Cardiac Surgeons in the United States. Annals Of Thoracic Surgery Short Reports 2026 DOI: 10.1016/j.atssr.2026.04.013.
- Hassab A, Antonios J, Chou A, Williams M, Geirsson A, Vallabhajosyula P, Assi R. Contemporary Outcomes and Predictors of Adverse Events After Repair of Acute Type A Aortic Dissection: Report From an Aortic Center. Journal Of Cardiac Surgery 2025, 2025 DOI: 10.1155/jocs/6991973.
- Pitoulis F, Tauber K, Atluri P, Szeto W, Anwarruddin S, Kobayashi T, Desai N, Cevasco M, Bermudez C, Acker M, Williams M, Ibrahim M. The Challenges of Aortic Valve Management After Left Ventricular Assist Device Implantation. Annals Of Thoracic Surgery Short Reports 2024, 2: 567-572. PMID: 39790404, PMCID: PMC11708590, DOI: 10.1016/j.atssr.2024.04.028.
- Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.
- Iyengar A, Patrick W, Helmers M, Kelly J, Han J, Williams M, Mackay E, Desai N, Cevasco M. Neighborhood Socioeconomic Status Independently Predicts Outcomes After Mitral Valve Surgery. The Annals Of Thoracic Surgery 2023, 115: 940-947. PMID: 36623633, DOI: 10.1016/j.athoracsur.2023.01.002.
- Ibrahim M, Acker A, Weiss S, Lawrence K, Ottemiller S, McGarvey J, Epler M, Williams M, Szeto W, Acker M. Balancing quality and quaternary care imperative using a high-risk case review committee in adults. Interdisciplinary Cardiovascular And Thoracic Surgery 2022, 35: ivac268. PMID: 36315100, PMCID: PMC9651973, DOI: 10.1093/icvts/ivac268.
- Coronary Endarterectomy: Analysis of The Society of Thoracic Surgeons Adult Cardiac Surgery DatabaseKelly J, Han J, Desai N, Iyengar A, Acker A, Grau-Sepulveda M, Zwischenberger B, Jawitz O, Hargrove W, Szeto W, Williams M. Coronary Endarterectomy: Analysis of The Society of Thoracic Surgeons Adult Cardiac Surgery Database. The Annals Of Thoracic Surgery 2022, 114: 667-674. PMID: 35292259, DOI: 10.1016/j.athoracsur.2022.01.067.
- Shang M, Weininger G, Mori M, Kahler‐Quesada A, Degife E, Brooks C, Yousef S, Williams M, Assi R, Geirsson A, Vallabhajosyula P. Socioeconomic disparities in surveillance and follow‐up of patients with thoracic aortic aneurysm. Journal Of Cardiac Surgery 2021, 37: 831-839. PMID: 34873754, DOI: 10.1111/jocs.16173.
- Ibrahim M, Szeto W, Gutsche J, Weiss S, Bavaria J, Ottemiller S, Williams M, Gallagher J, Fishman N, Cunningham R, Brady L, Brennan P, Acker M. Transparency, Public Reporting, and a Culture of Change to Quality and Safety in Cardiac Surgery. The Annals Of Thoracic Surgery 2021, 114: 626-635. PMID: 34843698, DOI: 10.1016/j.athoracsur.2021.08.085.
- Patrick W, Iyengar A, Han J, Mays J, Helmers M, Kelly J, Wang X, Ghoreishi M, Taylor B, Atluri P, Desai N, Williams M. The learning curve of robotic coronary arterial bypass surgery: A report from the STS database. Journal Of Cardiac Surgery 2021, 36: 4178-4186. PMID: 34459029, PMCID: PMC9128069, DOI: 10.1111/jocs.15945.
- Ibrahim M, Acker M, Szeto W, Gutsche J, Williams M, Atluri P, Woods M, Richards T, Gardner T, McGarvey J, Epler M, Wald J, Rame E, Birati E, Bermudez C. Proposal for a trial of early left ventricular venting during venoarterial extracorporeal membrane oxygenation for cardiogenic shock. JTCVS Open 2021, 8: 393-400. PMID: 36004109, PMCID: PMC9390694, DOI: 10.1016/j.xjon.2021.07.024.
- Smood B, Spratt J, Mehaffey J, Luc J, Vinck E, Lehtinen M, Wallen T, Jenkinson C, Kim W, Kesieme E, Han J, Helmers M, Iyengar A, Patrick W, Kelly J, Watkins A, Cevasco M, Williams M. COVID‐19 and cardiothoracic surgery: Effects on training and workforce utilization in a global pandemic. Journal Of Cardiac Surgery 2021, 36: 3296-3305. PMID: 34173279, PMCID: PMC8447436, DOI: 10.1111/jocs.15773.
- Sperry A, Williams M, Atluri P, Szeto W, Cevasco M, Bermudez C, Acker M, Ibrahim M. The Surgeon’s Role in Cardiogenic Shock. Current Heart Failure Reports 2021, 18: 240-251. PMID: 33956313, DOI: 10.1007/s11897-021-00514-1.
- Han J, Mays J, Iyengar A, Luc J, Patrick W, Helmers M, Smood B, Kelly J, Williams M, Szeto W, Cevasco M. Wisdom From Past Presidents of The Society of Thoracic Surgeons. The Annals Of Thoracic Surgery 2021, 112: 1372-1377. PMID: 33905726, DOI: 10.1016/j.athoracsur.2021.04.031.
- Ibrahim M, Spelde A, Szeto W, Acker M, Atluri P, Grimm J, Cevasco M, Vallabhajosyula P, Bavaria J, Desai N, Williams M. Clinical and Echocardiographic Results of Aortic Valve Replacement in the Failing Ventricle: Do Aortic Stenosis and Aortic Regurgitation Differ? The Annals Of Thoracic Surgery 2021, 113: 853-858. PMID: 33631158, PMCID: PMC9774041, DOI: 10.1016/j.athoracsur.2021.02.016.
- Han J, Mays J, Sukhavasi A, Patrick W, Helmers M, Iyengar A, Smood B, Kelly J, Williams M, Szeto W, Cevasco M. Characteristics and Attitudes of Aspiring Cardiothoracic Surgeons: A Survey Study. The Annals Of Thoracic Surgery 2021, 112: 2063-2069. PMID: 33548275, DOI: 10.1016/j.athoracsur.2021.01.040.
- Ibrahim M, Spelde A, Gutsche J, Cevasco M, Bermudez C, Desai N, Szeto W, Atluri P, Acker M, Williams M. Coronary Artery Bypass Grafting in Cardiogenic Shock: Decision-Making, Management Options, and Outcomes. Journal Of Cardiothoracic And Vascular Anesthesia 2020, 35: 2144-2154. PMID: 33268279, DOI: 10.1053/j.jvca.2020.09.108.
- Patrick W, Bojko M, Han J, Kelly J, Iyengar A, Helmers M, Smood B, McCarthy F, Williams M. Neighborhood socioeconomic status is associated with differences in operative management and long-term survival after coronary artery bypass grafting. Journal Of Thoracic And Cardiovascular Surgery 2020, 164: 92-102.e8. PMID: 32977962, PMCID: PMC7959671, DOI: 10.1016/j.jtcvs.2020.08.024.
- Bojko MM, Habertheuer A, Bavaria JE, Suhail M, Hu RW, Harmon J, Desai ND, Milewski RK, Williams ML, Szeto WY, Mossey J, Vallabhajosyula P. Recurrent aortic insufficiency after emergency surgery for acute type A aortic dissection with aortic root preservation. Journal Of Thoracic And Cardiovascular Surgery 2020, 161: 1989-2000.e6. PMID: 32631661, DOI: 10.1016/j.jtcvs.2020.01.116.
- Bojko MM, Suhail M, Bavaria JE, Habertheuer A, Hu RW, Harmon J, Desai ND, Milewski RK, Williams ML, Szeto WY, Vallabhajosyula P. Fate of the Preserved Sinuses of Valsalva After Emergency Repair for Acute Type A Aortic Dissection. The Annals Of Thoracic Surgery 2020, 110: 1476-1483. PMID: 32156587, DOI: 10.1016/j.athoracsur.2020.01.083.
- Wang L, Williams M, Chen Y, Chen J. Novel Two-Phase Sampling Designs for Studying Binary Outcomes. Biometrics 2019, 76: 210-223. PMID: 31449330, PMCID: PMC7042058, DOI: 10.1111/biom.13140.
- Mehaffey J, Hawkins R, Charles E, Thibault D, Williams M, Brennan M, Thourani V, Badhwar V, Ailawadi G. Distressed communities are associated with worse outcomes after coronary artery bypass surgery. Journal Of Thoracic And Cardiovascular Surgery 2019, 160: 425-432.e9. PMID: 31543309, DOI: 10.1016/j.jtcvs.2019.06.104.
- Bhardwaj A, Miano T, Geller B, Milewski RC, Williams M, Bermudez C, Vallabhajosyula P, Patel P, Mackay E, Vernick W, Lane-Fall M, Raiten J, McDonald M, Haddle J, Gutsche J. Venovenous Extracorporeal Membrane Oxygenation for Patients With Return of Spontaneous Circulation After Cardiac Arrest Owing to Acute Respiratory Distress Syndrome. Journal Of Cardiothoracic And Vascular Anesthesia 2019, 33: 2216-2220. PMID: 31182376, DOI: 10.1053/j.jvca.2019.04.020.
- McCarthy F, Zhang L, Tam V, Chen J, Brown C, Patrick W, Hargrove W, Szeto W, Desai N, Wiebe D, Groeneveld P, Williams M. Geographically Derived Socioeconomic Factors to Improve Risk Prediction in Patients Having Aortic Valve Replacement. The American Journal Of Cardiology 2018, 123: 116-122. PMID: 30390990, PMCID: PMC6440469, DOI: 10.1016/j.amjcard.2018.09.019.
- Wallen TJ, Szeto W, Williams M, Atluri P, Arnaoutakis G, Fults M, Sultan I, Desai N, Acker M, Vallabhajosyula P. Tricuspid valve endocarditis in the era of the opioid epidemic. Journal Of Cardiac Surgery 2018, 33: 260-264. PMID: 29663522, DOI: 10.1111/jocs.13600.
- Cox M, Gulack B, Thibault D, He X, Williams M, Thourani V, Jacobs J, Brennan J, Daneshmand M, Acharya D. Outcomes after coronary artery bypass grafting in patients with myocardial infarction, cardiogenic shock and unresponsive neurological state: analysis of the Society of Thoracic Surgeons Database. European Journal Of Cardio-thoracic Surgery 2018, 54: 710-716. PMID: 29554232, PMCID: PMC13376260, DOI: 10.1093/ejcts/ezy114.
- McCarthy FH, Vemulapalli S, Li Z, Thourani V, Matsouaka RA, Desai ND, Kirtane A, Anwaruddin S, Williams ML, Giri J, Vallabhajosyula P, Li RH, Herrmann HC, Bavaria JE, Szeto WY. Association of Tricuspid Regurgitation With Transcatheter Aortic Valve Replacement Outcomes: A Report From The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. The Annals Of Thoracic Surgery 2018, 105: 1121-1128. PMID: 29502934, DOI: 10.1016/j.athoracsur.2017.11.018.
- Lee T, Kon Z, Cheema F, Grau‐Sepulveda M, Englum B, Kim S, Chaudhuri P, Thourani V, Ailawadi G, Hughes G, Williams M, Brennan J, Svensson L, Gammie J. Contemporary management and outcomes of acute type A aortic dissection: An analysis of the STS adult cardiac surgery database. Journal Of Cardiac Surgery 2018, 33: 7-18. PMID: 29314257, DOI: 10.1111/jocs.13511.
- Sultan I, Habertheuer A, Wallen T, Siki M, Szeto W, Bavaria JE, Williams M, Vallabhajosyula P. The role of extracorporeal membrane oxygenator therapy in the setting of Type A aortic dissection. Journal Of Cardiac Surgery 2017, 32: 822-825. PMID: 29216679, DOI: 10.1111/jocs.13245.
- Gutsche JT, Miano TA, Vernick W, Raiten J, Bermudez C, Vallabjoysula P, Milewski K, Szeto W, Fall ML, Williams ML, Patel P, Mikkelsen ME, Chiu C, Ramakrishna H, Canon J, Augoustides JG. Does a Mobile ECLS Program Reduce Mortality for Patients Transported for ECLS Therapy for Severe Acute Respiratory Failure? Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 1137-1141. PMID: 29153427, DOI: 10.1053/j.jvca.2017.08.050.
- Gutsche JT, Mikkelsen ME, McCarthy FH, Miano TA, Vernick WJ, Ramakrishna H, Patel PA, Augoustides Y, Szeto WY, Desai ND, Lane-Fall MB, Williams ML. In Response. Anesthesia & Analgesia 2017, 125: 706-707. PMID: 28654432, DOI: 10.1213/ane.0000000000002248.
- Gaffey A, Chen C, Chung J, Phillips E, Wald J, Williams M, Low D, Acker M, Atluri P. Improved Approach With Subcostal Exchange of the HeartMate II Left Ventricular Assist Device: Difference in On and Off Pump? The Annals Of Thoracic Surgery 2017, 104: 1540-1546. PMID: 28760470, DOI: 10.1016/j.athoracsur.2017.04.047.
- Kilic A, Arnaoutakis GJ, Bavaria JE, Sultan I, Desai ND, Vallabhajosyula P, Williams ML, Milewski RK, Szeto WY. Outcomes of Elective Aortic Hemiarch Reconstruction for Aneurysmal Disease in the Elderly. The Annals Of Thoracic Surgery 2017, 104: 1522-1530. PMID: 28648536, DOI: 10.1016/j.athoracsur.2017.03.067.
- Gutsche JT, Mikkelsen ME, McCarthy FH, Miano TA, Vernick WJ, Ramakrishna H, Patel PA, Augoustides Y, Szeto WY, Desai ND, Lane-Fall MB, Williams ML. Veno-Venous Extracorporeal Life Support in Hemodynamically Unstable Patients With ARDS. Anesthesia & Analgesia 2017, 124: 846-848. PMID: 27749338, PMCID: PMC5313331, DOI: 10.1213/ane.0000000000001646.
- Williams ML, Bavaria JE, Acker MA, Desai ND, Vallabhajosyula P, Hargrove WC, Atluri P, Szeto WY. Valve Selection in End-Stage Renal Disease: Should It Always Be Biological? The Annals Of Thoracic Surgery 2016, 102: 1531-1535. PMID: 27544289, DOI: 10.1016/j.athoracsur.2016.04.092.
- Arnaoutakis GJ, Vallabhajosyula P, Bavaria JE, Sultan I, Siki M, Naidu S, Milewski RK, Williams ML, Hargrove WC, Desai ND, Szeto WY. The Impact of Deep Versus Moderate Hypothermia on Postoperative Kidney Function After Elective Aortic Hemiarch Repair. The Annals Of Thoracic Surgery 2016, 102: 1313-1321. PMID: 27318775, DOI: 10.1016/j.athoracsur.2016.04.007.
- McCarthy FH, Bavaria JE, McDermott KM, Moeller P, Spragan D, Hoedt A, Dibble T, Savino D, Williams ML, Vallabhajosyula P, Szeto WY, Desai ND. At the Root of the Repair Debate: Outcomes After Elective Aortic Root Replacements for Aortic Insufficiency With Aneurysm. The Annals Of Thoracic Surgery 2016, 102: 1199-1205. PMID: 27261085, DOI: 10.1016/j.athoracsur.2016.03.071.
- Schumer E, Chaney J, Trivedi J, Linsky P, Williams M, Slaughter M. Emergency Coronary Artery Bypass Grafting: Indications and Outcomes from 2003 through 2013. Texas Heart Institute Journal 2016, 43: 214-9. PMID: 27303236, PMCID: PMC4894699, DOI: 10.14503/thij-14-4978.
- Vallabhajosyula P, Kramer M, Lazar S, McCarthy F, Rame E, Wald J, Szeto W, Williams M, Atluri P, Desai N, Acker M. Lower-extremity complications with femoral extracorporeal life support. Journal Of Thoracic And Cardiovascular Surgery 2016, 151: 1738-1744. PMID: 27207130, DOI: 10.1016/j.jtcvs.2015.11.044.
- Acharya D, Gulack B, Loyaga-Rendon R, Davies J, He X, Brennan J, Thourani V, Williams M. Clinical Characteristics and Outcomes of Patients With Myocardial Infarction and Cardiogenic Shock Undergoing Coronary Artery Bypass Surgery: Data From The Society of Thoracic Surgeons National Database. The Annals Of Thoracic Surgery 2015, 101: 558-566. PMID: 26718859, PMCID: PMC5142520, DOI: 10.1016/j.athoracsur.2015.10.051.
- Jassar AS, Vallabhajosyula P, Bavaria JE, Gutsche J, Desai ND, Williams ML, Milewski RK, Hargrove WC, Szeto WY. Direct innominate artery cannulation: An alternate technique for antegrade cerebral perfusion during aortic hemiarch reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2015, 151: 1073-1078. PMID: 26725716, DOI: 10.1016/j.jtcvs.2015.11.027.
- Trivedi J, Cheng A, Singh R, Williams M, Slaughter M. Survival on the Heart Transplant Waiting List: Impact of Continuous Flow Left Ventricular Assist Device as Bridge to Transplant. The Annals Of Thoracic Surgery 2014, 98: 830-834. PMID: 25087934, DOI: 10.1016/j.athoracsur.2014.05.019.
- Andersen N, Brennan J, Zhao Y, Williams J, Williams M, Smith P, Scarborough J, Hughes G. Insurance Status Is Associated With Acuity of Presentation and Outcomes for Thoracic Aortic Operations. Circulation Population Health And Outcomes 2014, 7: 398-406. PMID: 24714600, PMCID: PMC4031288, DOI: 10.1161/circoutcomes.113.000593.
- Vassileva C, Li S, Thourani V, Suri R, Williams M, Lee R, Rankin J. Outcome Characteristics of Multiple-Valve Surgery. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 27-32. PMID: 24402042, DOI: 10.1097/imi.0000000000000028.
- Vassileva C, Li S, Thourani V, Suri R, Williams M, Lee R, Rankin J. Outcome Characteristics of Multiple-Valve Surgery. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 27-32. DOI: 10.1177/155698451400900105.
- Pagni S, Ganzel B, Singh R, Austin E, Mascio C, Williams M, Akella P, Trivedi J. Clinical Outcome After Triple-Valve Operations in the Modern Era: Are Elderly Patients at Increased Surgical Risk? The Annals Of Thoracic Surgery 2013, 97: 569-576. PMID: 24140216, DOI: 10.1016/j.athoracsur.2013.07.083.
- Williams M, He X, Rankin J, Slaughter M, Gammie J. Preoperative Hematocrit Is a Powerful Predictor of Adverse Outcomes in Coronary Artery Bypass Graft Surgery: A Report From The Society of Thoracic Surgeons Adult Cardiac Surgery Database. The Annals Of Thoracic Surgery 2013, 96: 1628-1634. PMID: 24055236, DOI: 10.1016/j.athoracsur.2013.06.030.
- Gaca J, Sheng S, Daneshmand M, Rankin J, Williams M, O'Brien S, Gammie J. Current Outcomes for Tricuspid Valve Infective Endocarditis Surgery in North America. The Annals Of Thoracic Surgery 2013, 96: 1374-1381. PMID: 23968767, DOI: 10.1016/j.athoracsur.2013.05.046.
- Pagni S, Ganzel B, Trivedi J, Singh R, Mascio C, Austin E, Slaughter M, Williams M. Early and Midterm Outcomes Following Surgery for Acute Type A Aortic Dissection. Journal Of Cardiac Surgery 2013, 28: 543-549. PMID: 23909254, DOI: 10.1111/jocs.12170.
- Trivedi J, Sobieski M, Schwartz S, Williams M, Slaughter M. Novel Thrombosis Risk Index as Predictor of Left Ventricular Assist Device Thrombosis. ASAIO Journal 2013, 59: 380-383. PMID: 23820276, DOI: 10.1097/mat.0b013e318291d0c1.
- Keeling W, Williams M, Slaughter M, Zhao Y, Puskas J. Off-Pump and On-Pump Coronary Revascularization in Patients With Low Ejection Fraction: A Report From The Society of Thoracic Surgeons National Database. The Annals Of Thoracic Surgery 2013, 96: 83-89. PMID: 23743061, DOI: 10.1016/j.athoracsur.2013.03.098.
- Rankin J, Thourani V, Suri R, He X, O'Brien S, Vassileva C, Shah A, Williams M. Associations between valve repair and reduced operative mortality in 21 056 mitral/tricuspid double valve procedures†. European Journal Of Cardio-thoracic Surgery 2013, 44: 472-477. PMID: 23515166, DOI: 10.1093/ejcts/ezt077.
- Cannon R, Trivedi J, Pagni S, Dwivedi A, Bland J, Slaughter M, Ross C, Richardson J, Williams M. Open Repair of Blunt Thoracic Aortic Injury Remains Relevant in the Endovascular Era. Journal Of The American College Of Surgeons 2012, 214: 943-949. PMID: 22541985, DOI: 10.1016/j.jamcollsurg.2012.03.003.
- Williams M, Ganzel B, Slater A, Slaughter M, Trivedi J, Edmonds H, Pagni S. Antegrade versus Retrograde Cerebral Protection in Repair of Acute Ascending Aortic Dissection. The American Surgeon 2012, 78: 349-351. PMID: 22524776, DOI: 10.1177/000313481207800346.
- Pagni S, Slater A, Trivedi J, Williams M, Austin E, Mascio C, Ganzel B. Proximal Thoracic Aortic Replacement for Aneurysmal Disease Using the Freestyle Stentless Bioprosthesis: A 10-Year Experience. The Annals Of Thoracic Surgery 2011, 92: 873-879. PMID: 21871272, DOI: 10.1016/j.athoracsur.2011.04.093.
- Pagni S, Trivedi J, Ganzel B, Williams M, Kapoor N, Ross C, Slater A. Thoracic Aortic Mobile Thrombus: Is There a Role for Early Surgical Intervention? The Annals Of Thoracic Surgery 2011, 91: 1875-1881. PMID: 21529769, DOI: 10.1016/j.athoracsur.2011.02.011.
- Piacentino V, Williams M, Depp T, Garcia-Huerta K, Blue L, Lodge A, Mackensen G, Swaminathan M, Rogers J, Milano C. Impact of Tricuspid Valve Regurgitation in Patients Treated With Implantable Left Ventricular Assist Devices. The Annals Of Thoracic Surgery 2011, 91: 1342-1347. PMID: 21457940, DOI: 10.1016/j.athoracsur.2011.01.053.
- Williams M, Trivedi J, McCants K, Prabhu S, Birks E, Oliver L, Slaughter M. Heart Transplant vs Left Ventricular Assist Device in Heart Transplant-Eligible Patients. The Annals Of Thoracic Surgery 2011, 91: 1330-1334. PMID: 21439545, DOI: 10.1016/j.athoracsur.2011.01.062.
- Williams M, Trivedi J, Doughtie C, Slaughter M. Is Female Sex an Independent Risk Factor for Perioperative Transfusion in Coronary Artery Bypass Graft Surgery? Journal Of The American College Of Surgeons 2011, 212: 362-366. PMID: 21356488, DOI: 10.1016/j.jamcollsurg.2010.12.008.
- Williams M, Sheng S, Gammie J, Rankin J, Smith P, Hughes G. Aortic Dissection as a Complication of Cardiac Surgery: Report From The Society of Thoracic Surgeons Database. The Annals Of Thoracic Surgery 2010, 90: 1812-1817. PMID: 21095316, DOI: 10.1016/j.athoracsur.2010.05.023.
- Lee M, Kozitza R, Mudrick D, Williams M, Lodge A, Harrison J, Glower D. Intraoperative Device Closure of Postinfarction Ventricular Septal Defects. The Annals Of Thoracic Surgery 2010, 89: e48-e50. PMID: 20494012, DOI: 10.1016/j.athoracsur.2010.03.081.
- Williams M, Wechsler S, Hughes G. Two‐Stage Total Aortic Replacement for Loeys–Dietz Syndrome. Journal Of Cardiac Surgery 2010, 25: 223-224. PMID: 20492031, DOI: 10.1111/j.1540-8191.2009.00956.x.
- Williams M, Wechsler S, Hughes G. Two‐Stage Total Aortic Replacement for Loeys–Dietz Syndrome. Journal Of Cardiac Surgery 2010 PMID: 20070434, DOI: 10.1111/j.1540-8191.2010.00956.x.
- Williams M, Daneshmand M, Jollis J, Horton J, Shaw L, Swaminathan M, Davis R, Glower D, Smith P, Milano C. Mitral Gradients and Frequency of Recurrence of Mitral Regurgitation After Ring Annuloplasty for Ischemic Mitral Regurgitation. The Annals Of Thoracic Surgery 2009, 88: 1197-1201. PMID: 19766807, DOI: 10.1016/j.athoracsur.2009.06.022.
- Milano C, Daneshmand M, Rankin J, Honeycutt E, Williams M, Swaminathan M, Linblad L, Shaw L, Glower D, Smith P. Survival Prognosis and Surgical Management of Ischemic Mitral Regurgitation. The Annals Of Thoracic Surgery 2008, 86: 735-744. PMID: 18721554, DOI: 10.1016/j.athoracsur.2008.05.017.
- Hata J, Williams M, Schroder J, Lima B, Keys J, Blaxall B, Petrofski J, Jakoi A, Milano C, Koch W. Lymphocyte Levels of GRK2 (βARK1) Mirror Changes in the LVAD-Supported Failing Human Heart: Lower GRK2 Associated With Improved β-Adrenergic Signaling After Mechanical Unloading. Journal Of Cardiac Failure 2006, 12: 360-368. PMID: 16762799, DOI: 10.1016/j.cardfail.2006.02.011.
- Petrofski J, Hata J, Williams M, Parsa C, Thompson R, Hanish S, Gehrig T, Koch W, Milano C. A Gβγ inhibitor reduces intimal hyperplasia in aortocoronary saphenous vein grafts. Journal Of Thoracic And Cardiovascular Surgery 2005, 130: 1683-1690. PMID: 16308016, DOI: 10.1016/j.jtcvs.2005.01.024.
- Schroder J, Williams M, Hata J, Muhlbaier L, Swaminathan M, Mathew J, Glower D, O’Connor C, Smith P, Milano C. Impact of Mitral Valve Regurgitation Evaluated by Intraoperative Transesophageal Echocardiography on Long-Term Outcomes After Coronary Artery Bypass Grafting. Circulation 2005, 112: i293-8. PMID: 16159834, DOI: 10.1161/circulationaha.104.523472.
- Williams M, Muhlbaier L, Schroder J, Hata J, Peterson E, Smith P, Landolfo K, Messier R, Davis R, Milano C. Risk-Adjusted Short- and Long-Term Outcomes for On-Pump Versus Off-Pump Coronary Artery Bypass Surgery. Circulation 2005, 112: i366-70. PMID: 16159847, DOI: 10.1161/circulationaha.104.526012.
- Hata J, Petrofski J, Schroder J, Williams M, Timberlake S, Pippen A, Corwin M, Solan A, Jakoi A, Gehrig T, Kontos C, Milano C. Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts. Journal Of Thoracic And Cardiovascular Surgery 2005, 129: 1405-1413. PMID: 15942585, DOI: 10.1016/j.jtcvs.2004.11.048.
- Most P, Pleger S, Völkers M, Heidt B, Boerries M, Weichenhan D, Löffler E, Janssen P, Eckhart A, Martini J, Williams M, Katus H, Remppis A, Koch W. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. Journal Of Clinical Investigation 2004, 114: 1550-1563. PMID: 15578088, PMCID: PMC529280, DOI: 10.1172/jci21454.
- Hata J, Williams M, Koch W. Genetic manipulation of myocardial β-adrenergic receptor activation and desensitization. Journal Of Molecular And Cellular Cardiology 2004, 37: 11-21. PMID: 15242731, DOI: 10.1016/j.yjmcc.2004.03.014.
- Williams M, Rampersaud E, Wolfe W. A man with saphenous vein graft aneurysms after bypass surgery. The Annals Of Thoracic Surgery 2004, 77: 1815-1817. PMID: 15111195, DOI: 10.1016/s0003-4975(03)01144-5.
- Williams M, Hata J, Schroder J, Rampersaud E, Petrofski J, Jakoi A, Milano C, Koch W. Targeted β-Adrenergic Receptor Kinase (βARK1) Inhibition by Gene Transfer in Failing Human Hearts. Circulation 2004, 109: 1590-1593. PMID: 15051637, DOI: 10.1161/01.cir.0000125521.40985.28.
- Williams M, Koch W. Viral-Based Myocardial Gene Therapy Approaches to Alter Cardiac Function. Annual Review Of Physiology 2004, 66: 49-75. PMID: 14977396, DOI: 10.1146/annurev.physiol.66.032102.141555.
- Petrofski J, Hata J, Gehrig T, Hanish S, Williams M, Thompson R, Parsa C, Koch W, Milano C. Gene delivery to aortocoronary saphenous vein grafts in a large animal model of intimal hyperplasia. Journal Of Thoracic And Cardiovascular Surgery 2004, 127: 27-33. PMID: 14752409, DOI: 10.1016/j.jtcvs.2003.07.032.
- Yale Physicians Building800 Howard AvenueNew Haven, CT 06519
- Yale Physicians Building800 Howard AvenueNew Haven, CT 06519