- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519
- Winchester Center for Lung DiseaseNorth Haven Medical Center6 Devine StreetNorth Haven, CT 06473
Lauren Cohn, MD
Biography
Lauren Cohn, MD, is a pulmonologist who specializes in asthma, from mild cases to the most severe and complicated ones, and in the use of biologic drugs for severe asthma. She also cares for patients with other complex airway diseases and refractory cough.
Dr. Cohn has always had a deep passion for science and immunology, and when she became a physician, she wanted to apply her interests to respiratory diseases. “I worked in the laboratory doing research on the immunology of asthma using animal models for most of my career,” she says. As an immunologist, she had a special interest in inflammation and cytokines (substances secreted by certain immune system cells and have an effect on other cells). She has made major contributions to understanding the biological pathways that contribute to asthma.
But she found caring for patients with asthma has different rewards. “I like the intensity of pulmonary medicine because you work with complex patients and because of the potential positive impact that treatment can have,” she says. “Respiratory issues have a higher impact on life in general, so treatment can make an impressive difference in our patients’ lives.”
In addition to caring for Yale Medicine patients, Dr. Cohn is co-director of the Yale Center for Asthma and Airway Diseases at Yale and director of Biologics and Advanced Therapeutics for Airway Diseases at the VA Connecticut Healthcare System. She also conducts clinical research on the impact of various therapies in asthma and chronic obstructive pulmonary disease (COPD).
Titles
- Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine)
- Associate Director, MD/PHD Program
- Director, Newington VA Pulmonary Clinic, Medicine, VA Connecticut Health System
Education & Training
- Post-doctoral FellowYale School of Medicine (1995)
- Post-Doctoral Research FellowColumbia University College of Physicians and Surgeons (1993)
- FellowColumbia Presbyterian Medical Center (1993)
- Clinical FellowColumbia University College of Physicians and Surgeons (1991)
- ResidentColumbia-Presbyterian Medical Center (1990)
- MDUniversity of Minnesota (1987)
- BASmith College, Biology (1982)
Additional Information
- Alumni Achievement Award: Sarnoff Foundation (2018)
- Research Core Center Pilot Funding: Yale Rheumatic Diseases (2009)
- Career Investigator Award: American Lung Association (2004)
- NIH Award (declined): Cystic Fibrosis Foundation (2000)
- Mentored Clinical Scientist Award, 50th Anniversary Celebration: NIH/NHLBI (1998)
- Hellman Family Fellowship: Yale University (1998)
- Junior Faculty Research Award: Department of Internal Medicine, Yale School of Medicine (1998)
- Fellowship Award (declined): Parker B. Francis Foundation (1995)
- Clinical Investigator Development Award (K08): NIH/NHLBI (1995)
- Sarnoff Scholar Award: Sarnoff Foundation (1991)
- Yale CME Course. Phenotyping in the Clinic and Selection of Therapies Across the Spectrum of Airway Diseases (2019): Director
- Regeneron (2019): Leader, planner, presenter of advisory board to assess experience 6 months after FDA approval for dupilimab for asthma
- Novartis (2019): October 2019
- Yale Asthma CME Course. Severe Asthma 2018: Advances in Pathogenesis and Treatment (2018): Director
- Sanofi-Regeneron (2018 - Present): invited to participate in multiple advisory boards annually
- Pieris Pharmaceuticals (2018 - Present): Advisor
- GlaxoSmithKline (2017): Advisor
- Astrazeneca (2017 - Present): invited to join multiple advisory boards to discuss asthma biologic therapies
- Co-Chair, Yale New Haven Health Systems Population Health Clinical Integration Pulmonary Workgroup (2016 - 2019): Chair
- : Yale Asthma CME Course. Yale Severe Asthma 2016: A Personalized Approach to Therapy (2016): Director
- Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.
- Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.
- Chupp G, Liu Q, Adams T, Schupp J, Wilson G, Grant N, Gomez J, Cohn L, Kaminski N, Akuthota P, Weiss S, Glass K, Bleecker E, Meyers D, Tantisira K, Yan X. Activation of Adam12-SDC4 and CCL22-CCR4 Pathways in the Airway in Asthma. American Journal Of Respiratory And Critical Care Medicine 2023, 207: a5689-a5689. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5689.
- Liu Y, Rajeevan H, Simonov M, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Gomez J, Cohn L, Gautam S, Chupp G. Mortality Differences Among Patients with Airway Disease Hospitalized with COVID-19. American Journal Of Respiratory And Critical Care Medicine 2023, 207: a6297-a6297. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6297.
- Sher L, Passalacqua G, Taillé C, Cohn L, Daizadeh N, Pandit-Abid N, Soler X, Khodzhayev A, Jacob-Nara J, Deniz Y, Rowe P, Nag A, Zhang Y. The long-term effect of dupilumab on dyspnea, sleep, and activity in oral corticosteroid-dependent severe asthma. Annals Of Allergy Asthma & Immunology 2022, 130: 298-304. PMID: 36509407, DOI: 10.1016/j.anai.2022.12.002.
- Sher L, Passalacqua G, Cohn L, Daizadeh N, Pandit-Abid N, Ortiz B, Atenhan A, Thakur M, Khan A, Zhang Y. Effect of dupilumab on improving physical activity in patients with severe asthma. Pneumologie 2022, 76: s35-s35. DOI: 10.1055/s-0042-1747768.
- Sher L, Taillé C, Cohn L, Quirce S, Daizadeh N, Pandit-Abid N, Ortiz B, Nag A, Zhang Y. POSB359 Effect of Dupilumab on Physical and Work-Related Activity in Patients with Moderate-to-Severe Asthma: Liberty Asthma QUEST. Value In Health 2022, 25: s230. DOI: 10.1016/j.jval.2021.11.1126.
- Cohn L, Zhang Y, Wang J, Chen C, Ortiz B, Djandji M, Zhang S, Yang M, Zeiger R. REAL-WORLD EFFECTIVENESS OF DUPILUMAB ON PATIENT-REPORTED OUTCOMES AND SYMPTOMS IN ASTHMA: 3-MONTH FOLLOW-UP DATA FROM RESPIRE, AN OBSERVATIONAL STUDY WITH PATIENTS RECRUITED FROM A US DUPILUMAB PATIENT SUPPORT PROGRAM. Chest 2021, 160: a29-a30. DOI: 10.1016/j.chest.2021.07.075.
- Sher L, Quirce S, Passalacqua G, Taillé C, Cohn L, Daizadeh N, Pandit-Abid N, Ortiz B, Khan A, Zhang Y. Effect of dupilumab on improving physical activity in patients with severe asthma. 2021, pa880. DOI: 10.1183/13993003.congress-2021.pa880.
- Sher L, Passalacqua G, Taillé C, Cohn L, Quirce S, Daizadeh N, Pandit-Abid N, Ortiz B, Khan A, Zhang Y. Effect of dupilumab on patient-reported sleep outcomes in patients with severe asthma. 2021, pa3733. DOI: 10.1183/13993003.congress-2021.pa3733.
- Sher L, Wolfe R, Quirce S, Cohn L, Passalacqua G, Paggiaro P, Taillé C, Daizadeh N, Ortiz B, Pandit-Abid N, Khan A, Kamat S. DUPILUMAB IMPROVES PATIENT-REPORTED BREATHING IN ORAL CORTICOSTEROID-DEPENDENT SEVERE ASTHMA. Chest 2020, 158: a1752-a1754. DOI: 10.1016/j.chest.2020.08.1538.
- Yan X, Liu Q, Mihaljinec A, Gomez J, Cohn L, Chupp G. Cell Lineage Defined by Single Cell Transcriptomics of the Sputum in Asthma. 2019, a6085-a6085. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6085.
- Gomez J, Chen A, Yan X, Cohn L, Chupp G. MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in Asthma. 2019, a2929-a2929. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2929.
- Khanal S, Niu N, Huleihel L, Herazo-Maya J, Kaminski N, Cohn L, Britto C. BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammation. 2018, pa4254. DOI: 10.1183/13993003.congress-2018.pa4254.
- Gueble M, Holm C, Grant N, Ravage-Mass L, Levesh T, Estrom J, Kapagiannidou E, Liu Q, O'Connor P, Gomez-Villalobos J, Cohn L, Chupp G. Proinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroups. 2016, pa908. DOI: 10.1183/13993003.congress-2016.pa908.
- Chupp G, Yan X, Nezgovorova V, Grant N, Bradford W, Brophy C, Cohn L. MAPKAP kinase 2(MK2) expression is associated with severe asthma. 2016, pa4649. DOI: 10.1183/13993003.congress-2016.pa4649.
- Gomez J, Crisafi G, Holm C, Meyers D, Hawkins G, Bleecker E, Jarjour N, Cohn L, Chupp G. The Rs12141494 Polymorphism in CHI3L1 is Associated with Asthma Severity and Airway Expression of YKL-40. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a1057-a1057. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a1057.
- Chupp G, Michaud G, Puchalski J, Liu Q, Grant N, Holm C, Gomez-Villalobos J, Cohn L. Longitudinal Effects of Bronchial Thermoplasty on Blood Gene Expression: Modulation of Inflammatory and Neuron Function. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a6431-a6431. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a6431.
- Nezgovorova V, Liu Q, Niu N, Holm C, Grant N, Marone S, Ravage-Mass L, Lee C, Elias J, Cohn L, Chupp G. Sputum Expression of IL-13Rα2 Correlates with Airway Remodeling and Th2 Inflammation in Asthma. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a6052-a6052. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a6052.
- Yan X, Chu J, Gomez J, Koenigs M, Holm C, He X, Perez M, Zhao H, Mane S, Martinez F, Ober C, Nicolae D, Barnes K, London S, Gilliland F, Weiss S, Raby B, Cohn L, Chupp G. Non-Invasive Analysis of the Airway Transcriptome Discriminates Clinical Phenotypes of Asthma. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a6056-a6056. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a6056.
- Britto C, Liu Q, Niu N, Caputo C, Egan M, Cohn L. Dysregulation of Short Palate Lung Nasal Epithelium Clone-1 (SPLUNC1) in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a6004-a6004. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a6004.
- Britto C, Herazo-Maya J, Huleihel L, Niu N, Kaminski N, Cohn L. Short Palate Lung Nasal Epithelium Clone-1 (SPLUNC1) Promotes Airway Neutrophil Recruitment During Acute Lung Inflammation. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a3673-a3673. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a3673.
- Takyar S, Vasavada H, Zhang J, Ahangari F, Niu N, Liu Q, Lee C, Cohn L, Elias J. VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis. Journal Of Cell Biology 2013, 202: 2027oia101. DOI: 10.1083/jcb.2027oia101.
- Determination of Asthma Phenotypes by Unsupervised Transcriptomic Cluster Analysis of Induced SputumChupp G, Perez M, Gomez-Arroyo J, He S, Holm C, Cook D, Zhao H, Cohn L, Yan X. Determination of Asthma Phenotypes by Unsupervised Transcriptomic Cluster Analysis of Induced Sputum. American Journal Of Respiratory And Critical Care Medicine 2013, 187: a2328-a2328. DOI: 10.1164/ajrccm-conference.2013.187.1_meetingabstracts.a2328.
- Scatena R, Holm C, He S, Wright P, Sessa W, Cohn L, Gomez-Villalobos J, Mitchell A, Chupp G. Characterization Of The Poor Emotional Function Phenotype In Asthma. 2012, a3967-a3967. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3967.
- Britto C, Liu Q, Dela Cruz C, Cohn L. SPLUNC1 Is Inhibited In Common Respiratory Infections By Toll-Like Receptor (TLR) Activation And Inflammatory Cytokines. 2012, a1065-a1065. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1065.
- Mitchell C, Provost K, Niu N, Homer R, Cohn L. IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease. The Journal Of Immunology 2011, 187: 3815-3820. PMID: 21873527, PMCID: PMC3178669, DOI: 10.4049/jimmunol.1100436.
- Niu N, Provost K, Homer R, Cohn L. IFN-? Inhibits Goblet Cell Differentiation. 2011, a2052-a2052. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2052.
- Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. Journal Of Experimental Medicine 2010, 207: 2595-2607. PMID: 20975041, PMCID: PMC2989775, DOI: 10.1084/jem.20100786.
- Britto C, Curran D, Liu Q, Cohn L. Microbial And Inflammatory Signals Promote Airway Inflammation By Inhibiting The Epithelial Protein PLUNC. 2010, a1389-a1389. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1389.
- Liu Q, Curran D, Britto C, Patham B, Cohn L. PLUNC Is An Immunoregulatory Protein That Controls Eosinophilia In Allergic Airway Inflammation. 2010, a5595-a5595. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5595.
- Provost K, Niu N, Homer R, Cohn L. Interferon Gamma Inhibits Th2 Induced Mucus Metaplasia In Vivo Through Effects On Epithelial IL-4 And IL-13 Receptor Expression, And Inhibition Of Stat6 Phosphorylation. 2010, a4038-a4038. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4038.
- Cohn L, Provost K, Homer R, Niu N, Andreasen C. IFN-³ Acts On The Airway Epithelium To Regulate Allergic Airway Inflammation. 2010, a2485-a2485. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2485.
- Mitchell C, Provost K, Niu N, Homer R, Cohn L. Airway epithelium response to IFN-γ regulates allergic airway inflammation (91.7). The Journal Of Immunology 2010, 184: 91.7-91.7. DOI: 10.4049/jimmunol.184.supp.91.7.
- Curran DR, Cohn L. Advances in Mucous Cell Metaplasia. American Journal Of Respiratory Cell And Molecular Biology 2010, 42: 268-275. PMID: 19520914, PMCID: PMC2830403, DOI: 10.1165/rcmb.2009-0151tr.
- Niu N, Laufer T, Homer RJ, Cohn L. Cutting Edge: Limiting MHC Class II Expression to Dendritic Cells Alters the Ability to Develop Th2- Dependent Allergic Airway Inflammation. The Journal Of Immunology 2009, 183: 1523-1527. PMID: 19596982, DOI: 10.4049/jimmunol.0901349.
- Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-9104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.
- Caceres A, Brackmann M, Bessac B, Sui A, Cohn L, Jordt. Decreased Ovalbumin-Induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1. 2009, a6324. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6324.
- Caceres A, Brackmann M, Bessac B, Cohn L, Jordt S. Decreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1. The FASEB Journal 2009, 23: 580.10-580.10. DOI: 10.1096/fasebj.23.1_supplement.580.10.
- Niu N, Cohn L. Response to Comment on “A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract”. The Journal Of Immunology 2007, 178: 7501-7502. DOI: 10.4049/jimmunol.178.12.7501-a.
- Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract. The Journal Of Immunology 2007, 178: 3846-3855. PMID: 17339484, DOI: 10.4049/jimmunol.178.6.3846.
- Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.
- Whittaker L, Cohn L. Recent Concepts in the Pathogenesis and Treatment of Asthma. Clinical Pulmonary Medicine 2002, 9: 135-144. DOI: 10.1097/00045413-200205000-00001.
- Cohn L, Herrick C, Niu N, Homer R, Bottomly K. IL-4 Promotes Airway Eosinophilia by Suppressing IFN-γ Production: Defining a Novel Role for IFN-γ in the Regulation of Allergic Airway Inflammation. The Journal Of Immunology 2001, 166: 2760-2767. PMID: 11160342, DOI: 10.4049/jimmunol.166.4.2760.
- Das J, Chen C, Yang L, Cohn L, Ray P, Ray A. A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation. Nature Immunology 2001, 2: 45-50. PMID: 11135577, DOI: 10.1038/83158.
- Cohn L, Ray A. T-helper type 2 cell-directed therapy for asthma. Pharmacology & Therapeutics 2000, 88: 187-196. PMID: 11150597, DOI: 10.1016/s0163-7258(00)00091-7.
- Wang J, Homer R, Hong L, Cohn L, Lee C, Jung S, Elias J. IL-11 Selectively Inhibits Aeroallergen-Induced Pulmonary Eosinophilia and Th2 Cytokine Production. The Journal Of Immunology 2000, 165: 2222-2231. PMID: 10925310, DOI: 10.4049/jimmunol.165.4.2222.
- Cohn L, Homer R, Niu N, Bottomly K. T Helper 1 Cells and Interferon γ Regulate Allergic Airway Inflammation and Mucus Production. Journal Of Experimental Medicine 1999, 190: 1309-1318. PMID: 10544202, PMCID: PMC2195688, DOI: 10.1084/jem.190.9.1309.
- Zhang D, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A. Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3. Immunity 1999, 11: 473-482. PMID: 10549629, DOI: 10.1016/s1074-7613(00)80122-3.
- Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway InflammationYang L, Cohn L, Zhang D, Homer R, Ray A, Ray P. Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway Inflammation. Journal Of Experimental Medicine 1998, 188: 1739-1750. PMID: 9802985, PMCID: PMC2212522, DOI: 10.1084/jem.188.9.1739.
- Cohn L, Homer R, Marinov A, Rankin J, Bottomly K. Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production. Journal Of Experimental Medicine 1997, 186: 1737-1747. PMID: 9362533, PMCID: PMC2199146, DOI: 10.1084/jem.186.10.1737.
- Zhang D, Cohn L, Ray P, Bottomly K, Ray A. Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*. Journal Of Biological Chemistry 1997, 272: 21597-21603. PMID: 9261181, DOI: 10.1074/jbc.272.34.21597.
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519
- Winchester Center for Lung DiseaseNorth Haven Medical Center6 Devine StreetNorth Haven, CT 06473
Biography
Lauren Cohn, MD, is a pulmonologist who specializes in asthma, from mild cases to the most severe and complicated ones, and in the use of biologic drugs for severe asthma. She also cares for patients with other complex airway diseases and refractory cough.
Dr. Cohn has always had a deep passion for science and immunology, and when she became a physician, she wanted to apply her interests to respiratory diseases. “I worked in the laboratory doing research on the immunology of asthma using animal models for most of my career,” she says. As an immunologist, she had a special interest in inflammation and cytokines (substances secreted by certain immune system cells and have an effect on other cells). She has made major contributions to understanding the biological pathways that contribute to asthma.
But she found caring for patients with asthma has different rewards. “I like the intensity of pulmonary medicine because you work with complex patients and because of the potential positive impact that treatment can have,” she says. “Respiratory issues have a higher impact on life in general, so treatment can make an impressive difference in our patients’ lives.”
In addition to caring for Yale Medicine patients, Dr. Cohn is co-director of the Yale Center for Asthma and Airway Diseases at Yale and director of Biologics and Advanced Therapeutics for Airway Diseases at the VA Connecticut Healthcare System. She also conducts clinical research on the impact of various therapies in asthma and chronic obstructive pulmonary disease (COPD).
Titles
- Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine)
- Associate Director, MD/PHD Program
- Director, Newington VA Pulmonary Clinic, Medicine, VA Connecticut Health System
Education & Training
- Post-doctoral FellowYale School of Medicine (1995)
- Post-Doctoral Research FellowColumbia University College of Physicians and Surgeons (1993)
- FellowColumbia Presbyterian Medical Center (1993)
- Clinical FellowColumbia University College of Physicians and Surgeons (1991)
- ResidentColumbia-Presbyterian Medical Center (1990)
- MDUniversity of Minnesota (1987)
- BASmith College, Biology (1982)
Additional Information
- Alumni Achievement Award: Sarnoff Foundation (2018)
- Research Core Center Pilot Funding: Yale Rheumatic Diseases (2009)
- Career Investigator Award: American Lung Association (2004)
- NIH Award (declined): Cystic Fibrosis Foundation (2000)
- Mentored Clinical Scientist Award, 50th Anniversary Celebration: NIH/NHLBI (1998)
- Hellman Family Fellowship: Yale University (1998)
- Junior Faculty Research Award: Department of Internal Medicine, Yale School of Medicine (1998)
- Fellowship Award (declined): Parker B. Francis Foundation (1995)
- Clinical Investigator Development Award (K08): NIH/NHLBI (1995)
- Sarnoff Scholar Award: Sarnoff Foundation (1991)
- Yale CME Course. Phenotyping in the Clinic and Selection of Therapies Across the Spectrum of Airway Diseases (2019): Director
- Regeneron (2019): Leader, planner, presenter of advisory board to assess experience 6 months after FDA approval for dupilimab for asthma
- Novartis (2019): October 2019
- Yale Asthma CME Course. Severe Asthma 2018: Advances in Pathogenesis and Treatment (2018): Director
- Sanofi-Regeneron (2018 - Present): invited to participate in multiple advisory boards annually
- Pieris Pharmaceuticals (2018 - Present): Advisor
- GlaxoSmithKline (2017): Advisor
- Astrazeneca (2017 - Present): invited to join multiple advisory boards to discuss asthma biologic therapies
- Co-Chair, Yale New Haven Health Systems Population Health Clinical Integration Pulmonary Workgroup (2016 - 2019): Chair
- : Yale Asthma CME Course. Yale Severe Asthma 2016: A Personalized Approach to Therapy (2016): Director
- Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.
- Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.
- Chupp G, Liu Q, Adams T, Schupp J, Wilson G, Grant N, Gomez J, Cohn L, Kaminski N, Akuthota P, Weiss S, Glass K, Bleecker E, Meyers D, Tantisira K, Yan X. Activation of Adam12-SDC4 and CCL22-CCR4 Pathways in the Airway in Asthma. American Journal Of Respiratory And Critical Care Medicine 2023, 207: a5689-a5689. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5689.
- Liu Y, Rajeevan H, Simonov M, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Gomez J, Cohn L, Gautam S, Chupp G. Mortality Differences Among Patients with Airway Disease Hospitalized with COVID-19. American Journal Of Respiratory And Critical Care Medicine 2023, 207: a6297-a6297. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6297.
- Sher L, Passalacqua G, Taillé C, Cohn L, Daizadeh N, Pandit-Abid N, Soler X, Khodzhayev A, Jacob-Nara J, Deniz Y, Rowe P, Nag A, Zhang Y. The long-term effect of dupilumab on dyspnea, sleep, and activity in oral corticosteroid-dependent severe asthma. Annals Of Allergy Asthma & Immunology 2022, 130: 298-304. PMID: 36509407, DOI: 10.1016/j.anai.2022.12.002.
- Sher L, Passalacqua G, Cohn L, Daizadeh N, Pandit-Abid N, Ortiz B, Atenhan A, Thakur M, Khan A, Zhang Y. Effect of dupilumab on improving physical activity in patients with severe asthma. Pneumologie 2022, 76: s35-s35. DOI: 10.1055/s-0042-1747768.
- Sher L, Taillé C, Cohn L, Quirce S, Daizadeh N, Pandit-Abid N, Ortiz B, Nag A, Zhang Y. POSB359 Effect of Dupilumab on Physical and Work-Related Activity in Patients with Moderate-to-Severe Asthma: Liberty Asthma QUEST. Value In Health 2022, 25: s230. DOI: 10.1016/j.jval.2021.11.1126.
- Cohn L, Zhang Y, Wang J, Chen C, Ortiz B, Djandji M, Zhang S, Yang M, Zeiger R. REAL-WORLD EFFECTIVENESS OF DUPILUMAB ON PATIENT-REPORTED OUTCOMES AND SYMPTOMS IN ASTHMA: 3-MONTH FOLLOW-UP DATA FROM RESPIRE, AN OBSERVATIONAL STUDY WITH PATIENTS RECRUITED FROM A US DUPILUMAB PATIENT SUPPORT PROGRAM. Chest 2021, 160: a29-a30. DOI: 10.1016/j.chest.2021.07.075.
- Sher L, Quirce S, Passalacqua G, Taillé C, Cohn L, Daizadeh N, Pandit-Abid N, Ortiz B, Khan A, Zhang Y. Effect of dupilumab on improving physical activity in patients with severe asthma. 2021, pa880. DOI: 10.1183/13993003.congress-2021.pa880.
- Sher L, Passalacqua G, Taillé C, Cohn L, Quirce S, Daizadeh N, Pandit-Abid N, Ortiz B, Khan A, Zhang Y. Effect of dupilumab on patient-reported sleep outcomes in patients with severe asthma. 2021, pa3733. DOI: 10.1183/13993003.congress-2021.pa3733.
- Sher L, Wolfe R, Quirce S, Cohn L, Passalacqua G, Paggiaro P, Taillé C, Daizadeh N, Ortiz B, Pandit-Abid N, Khan A, Kamat S. DUPILUMAB IMPROVES PATIENT-REPORTED BREATHING IN ORAL CORTICOSTEROID-DEPENDENT SEVERE ASTHMA. Chest 2020, 158: a1752-a1754. DOI: 10.1016/j.chest.2020.08.1538.
- Yan X, Liu Q, Mihaljinec A, Gomez J, Cohn L, Chupp G. Cell Lineage Defined by Single Cell Transcriptomics of the Sputum in Asthma. 2019, a6085-a6085. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6085.
- Gomez J, Chen A, Yan X, Cohn L, Chupp G. MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in Asthma. 2019, a2929-a2929. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2929.
- Khanal S, Niu N, Huleihel L, Herazo-Maya J, Kaminski N, Cohn L, Britto C. BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammation. 2018, pa4254. DOI: 10.1183/13993003.congress-2018.pa4254.
- Gueble M, Holm C, Grant N, Ravage-Mass L, Levesh T, Estrom J, Kapagiannidou E, Liu Q, O'Connor P, Gomez-Villalobos J, Cohn L, Chupp G. Proinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroups. 2016, pa908. DOI: 10.1183/13993003.congress-2016.pa908.
- Chupp G, Yan X, Nezgovorova V, Grant N, Bradford W, Brophy C, Cohn L. MAPKAP kinase 2(MK2) expression is associated with severe asthma. 2016, pa4649. DOI: 10.1183/13993003.congress-2016.pa4649.
- Gomez J, Crisafi G, Holm C, Meyers D, Hawkins G, Bleecker E, Jarjour N, Cohn L, Chupp G. The Rs12141494 Polymorphism in CHI3L1 is Associated with Asthma Severity and Airway Expression of YKL-40. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a1057-a1057. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a1057.
- Chupp G, Michaud G, Puchalski J, Liu Q, Grant N, Holm C, Gomez-Villalobos J, Cohn L. Longitudinal Effects of Bronchial Thermoplasty on Blood Gene Expression: Modulation of Inflammatory and Neuron Function. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a6431-a6431. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a6431.
- Nezgovorova V, Liu Q, Niu N, Holm C, Grant N, Marone S, Ravage-Mass L, Lee C, Elias J, Cohn L, Chupp G. Sputum Expression of IL-13Rα2 Correlates with Airway Remodeling and Th2 Inflammation in Asthma. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a6052-a6052. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a6052.
- Yan X, Chu J, Gomez J, Koenigs M, Holm C, He X, Perez M, Zhao H, Mane S, Martinez F, Ober C, Nicolae D, Barnes K, London S, Gilliland F, Weiss S, Raby B, Cohn L, Chupp G. Non-Invasive Analysis of the Airway Transcriptome Discriminates Clinical Phenotypes of Asthma. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a6056-a6056. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a6056.
- Britto C, Liu Q, Niu N, Caputo C, Egan M, Cohn L. Dysregulation of Short Palate Lung Nasal Epithelium Clone-1 (SPLUNC1) in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a6004-a6004. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a6004.
- Britto C, Herazo-Maya J, Huleihel L, Niu N, Kaminski N, Cohn L. Short Palate Lung Nasal Epithelium Clone-1 (SPLUNC1) Promotes Airway Neutrophil Recruitment During Acute Lung Inflammation. American Journal Of Respiratory And Critical Care Medicine 2015, 191: a3673-a3673. DOI: 10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a3673.
- Takyar S, Vasavada H, Zhang J, Ahangari F, Niu N, Liu Q, Lee C, Cohn L, Elias J. VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis. Journal Of Cell Biology 2013, 202: 2027oia101. DOI: 10.1083/jcb.2027oia101.
- Determination of Asthma Phenotypes by Unsupervised Transcriptomic Cluster Analysis of Induced SputumChupp G, Perez M, Gomez-Arroyo J, He S, Holm C, Cook D, Zhao H, Cohn L, Yan X. Determination of Asthma Phenotypes by Unsupervised Transcriptomic Cluster Analysis of Induced Sputum. American Journal Of Respiratory And Critical Care Medicine 2013, 187: a2328-a2328. DOI: 10.1164/ajrccm-conference.2013.187.1_meetingabstracts.a2328.
- Scatena R, Holm C, He S, Wright P, Sessa W, Cohn L, Gomez-Villalobos J, Mitchell A, Chupp G. Characterization Of The Poor Emotional Function Phenotype In Asthma. 2012, a3967-a3967. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3967.
- Britto C, Liu Q, Dela Cruz C, Cohn L. SPLUNC1 Is Inhibited In Common Respiratory Infections By Toll-Like Receptor (TLR) Activation And Inflammatory Cytokines. 2012, a1065-a1065. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1065.
- Mitchell C, Provost K, Niu N, Homer R, Cohn L. IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease. The Journal Of Immunology 2011, 187: 3815-3820. PMID: 21873527, PMCID: PMC3178669, DOI: 10.4049/jimmunol.1100436.
- Niu N, Provost K, Homer R, Cohn L. IFN-? Inhibits Goblet Cell Differentiation. 2011, a2052-a2052. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2052.
- Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. Journal Of Experimental Medicine 2010, 207: 2595-2607. PMID: 20975041, PMCID: PMC2989775, DOI: 10.1084/jem.20100786.
- Britto C, Curran D, Liu Q, Cohn L. Microbial And Inflammatory Signals Promote Airway Inflammation By Inhibiting The Epithelial Protein PLUNC. 2010, a1389-a1389. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1389.
- Liu Q, Curran D, Britto C, Patham B, Cohn L. PLUNC Is An Immunoregulatory Protein That Controls Eosinophilia In Allergic Airway Inflammation. 2010, a5595-a5595. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5595.
- Provost K, Niu N, Homer R, Cohn L. Interferon Gamma Inhibits Th2 Induced Mucus Metaplasia In Vivo Through Effects On Epithelial IL-4 And IL-13 Receptor Expression, And Inhibition Of Stat6 Phosphorylation. 2010, a4038-a4038. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4038.
- Cohn L, Provost K, Homer R, Niu N, Andreasen C. IFN-³ Acts On The Airway Epithelium To Regulate Allergic Airway Inflammation. 2010, a2485-a2485. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2485.
- Mitchell C, Provost K, Niu N, Homer R, Cohn L. Airway epithelium response to IFN-γ regulates allergic airway inflammation (91.7). The Journal Of Immunology 2010, 184: 91.7-91.7. DOI: 10.4049/jimmunol.184.supp.91.7.
- Curran DR, Cohn L. Advances in Mucous Cell Metaplasia. American Journal Of Respiratory Cell And Molecular Biology 2010, 42: 268-275. PMID: 19520914, PMCID: PMC2830403, DOI: 10.1165/rcmb.2009-0151tr.
- Niu N, Laufer T, Homer RJ, Cohn L. Cutting Edge: Limiting MHC Class II Expression to Dendritic Cells Alters the Ability to Develop Th2- Dependent Allergic Airway Inflammation. The Journal Of Immunology 2009, 183: 1523-1527. PMID: 19596982, DOI: 10.4049/jimmunol.0901349.
- Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-9104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.
- Caceres A, Brackmann M, Bessac B, Sui A, Cohn L, Jordt. Decreased Ovalbumin-Induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1. 2009, a6324. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6324.
- Caceres A, Brackmann M, Bessac B, Cohn L, Jordt S. Decreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1. The FASEB Journal 2009, 23: 580.10-580.10. DOI: 10.1096/fasebj.23.1_supplement.580.10.
- Niu N, Cohn L. Response to Comment on “A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract”. The Journal Of Immunology 2007, 178: 7501-7502. DOI: 10.4049/jimmunol.178.12.7501-a.
- Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract. The Journal Of Immunology 2007, 178: 3846-3855. PMID: 17339484, DOI: 10.4049/jimmunol.178.6.3846.
- Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.
- Whittaker L, Cohn L. Recent Concepts in the Pathogenesis and Treatment of Asthma. Clinical Pulmonary Medicine 2002, 9: 135-144. DOI: 10.1097/00045413-200205000-00001.
- Cohn L, Herrick C, Niu N, Homer R, Bottomly K. IL-4 Promotes Airway Eosinophilia by Suppressing IFN-γ Production: Defining a Novel Role for IFN-γ in the Regulation of Allergic Airway Inflammation. The Journal Of Immunology 2001, 166: 2760-2767. PMID: 11160342, DOI: 10.4049/jimmunol.166.4.2760.
- Das J, Chen C, Yang L, Cohn L, Ray P, Ray A. A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation. Nature Immunology 2001, 2: 45-50. PMID: 11135577, DOI: 10.1038/83158.
- Cohn L, Ray A. T-helper type 2 cell-directed therapy for asthma. Pharmacology & Therapeutics 2000, 88: 187-196. PMID: 11150597, DOI: 10.1016/s0163-7258(00)00091-7.
- Wang J, Homer R, Hong L, Cohn L, Lee C, Jung S, Elias J. IL-11 Selectively Inhibits Aeroallergen-Induced Pulmonary Eosinophilia and Th2 Cytokine Production. The Journal Of Immunology 2000, 165: 2222-2231. PMID: 10925310, DOI: 10.4049/jimmunol.165.4.2222.
- Cohn L, Homer R, Niu N, Bottomly K. T Helper 1 Cells and Interferon γ Regulate Allergic Airway Inflammation and Mucus Production. Journal Of Experimental Medicine 1999, 190: 1309-1318. PMID: 10544202, PMCID: PMC2195688, DOI: 10.1084/jem.190.9.1309.
- Zhang D, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A. Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3. Immunity 1999, 11: 473-482. PMID: 10549629, DOI: 10.1016/s1074-7613(00)80122-3.
- Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway InflammationYang L, Cohn L, Zhang D, Homer R, Ray A, Ray P. Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway Inflammation. Journal Of Experimental Medicine 1998, 188: 1739-1750. PMID: 9802985, PMCID: PMC2212522, DOI: 10.1084/jem.188.9.1739.
- Cohn L, Homer R, Marinov A, Rankin J, Bottomly K. Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production. Journal Of Experimental Medicine 1997, 186: 1737-1747. PMID: 9362533, PMCID: PMC2199146, DOI: 10.1084/jem.186.10.1737.
- Zhang D, Cohn L, Ray P, Bottomly K, Ray A. Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*. Journal Of Biological Chemistry 1997, 272: 21597-21603. PMID: 9261181, DOI: 10.1074/jbc.272.34.21597.
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- Winchester Center for Lung DiseaseNorth Haven Medical Center6 Devine StreetNorth Haven, CT 06473
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519
- Winchester Center for Lung DiseaseNorth Haven Medical Center6 Devine StreetNorth Haven, CT 06473