Junghee Jenny Shin, MD, PhD
she/her/hers
Internal Medicine, Allergy & Clinical Immunology
Telehealth is available
Patient type treated
Child, Adult
Accepting new patients
Yes
Referral required
From physicians only
Board Certified in
Internal Medicine
Titles
- Assistant Professor
Education & Training
- Clinical FellowYale University School of Medicine (2020)
- ResidencyYale New Haven Health - Bridgeport Hospital (2017)
- MDRoss University School of Medicine
- Post doctoral research fellowMassachusetts General Hospital - Harvard Medical School (2010)
- PhDNew York Medical College, Microbiology and Immunology
Additional Information
Honors & Recognitions
- Immunodeficiency Foundation research award: Immunodeficiency Foundation (2023)
- HyperIgM Foundation research award: Hyper IgM Foundation (2022)
- Federation of Clinical Immunology Societies Research Award: Federation of Clinical Immunology Societies (2021)
- Yale Center for Clinical Investigation Scholar: Yale University School of Medicine (2021)
- First place, oral presentation : Education and Research Day of Yale New Haven Health (2015)
- Graduate Faculty Council Award: New York Medical College (2005)
- Scholarship for the study of Lyme disease 1994: Walter J. and Lille A. Berbecker Foundation (2005)
Publications
- Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, You S, Racke M, Bucala R, Kang I. Modulating IL-1β and its receptors shapes spike-specific CD4 +T cell responses to mRNA vaccination. The Journal Of Immunology 2023, 210: 159.20-159.20. DOI: 10.4049/jimmunol.210.supp.159.20.
- Ünlü S, Shin J, Par-Young J, Simonov M, Vinetz J, Petrylak D, Kang I, Kim J. Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients. Cancer Investigation 2022, 41: 77-83. PMID: 36373994, DOI: 10.1080/07357907.2022.2139839.
- Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a Common Genetic Determinant of COVID-19 Symptomatic Infection and Severity. QJM 2022, 116: hcac234. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.
- Shin JJ, Par-Young J, Unlu S, McNamara A, Park HJ, Shin MS, Gee RJ, Doyle H, Afinogenova Y, Zidan E, Kwah J, Russo A, Mamula M, Hsu FI, Catanzaro J, Racke M, Bucala R, Wilen C, Kang I. Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency. Journal Of Clinical Immunology 2022, 42: 1137-1150. PMID: 35713752, PMCID: PMC9203263, DOI: 10.1007/s10875-022-01296-4.
- Unlu S, Shin J, Par-Young J, Vinetz J, Petrylak D, Kang I, Kim J. Effect of androgen receptor directed therapy in prostate cancer patients with COVID-19. Journal Of Clinical Oncology 2022, 40: 161-161. DOI: 10.1200/jco.2022.40.6_suppl.161.
- Shin J, Kaman K, Anthonypillai J, Soffer G, Kang I. Peripheral Blood Cell Counts Predict Distinct Endoscopic Phenotypes In Eosinophilic Esophagitis. Journal Of Allergy And Clinical Immunology 2022, 149: ab204. DOI: 10.1016/j.jaci.2021.12.670.
- Kuster JK, Unlu S, Makin TA, Par-Young J, Simonov M, Shafi S, Balanda M, Randolph C, Steele R, Hsu FI, Price C, Kohli-Pamnani A, Borish L, Lawrence MG, Kang I, Shin JJ. Low IgG trough and lymphocyte subset counts are associated with hospitalization for COVID-19 in patients with primary antibody deficiency. The Journal Of Allergy And Clinical Immunology In Practice 2021, 10: 633-636.e3. PMID: 34929372, PMCID: PMC8683251, DOI: 10.1016/j.jaip.2021.11.030.
- Shin JJ, Jeon S, Unlu S, Par-Young J, Shin MS, Kuster JK, Afinogenova Y, Kang Y, Simonov M, Buller G, Bucala R, Kang I. A distinct association of inflammatory molecules with outcomes of COVID-19 in younger versus older adults. Clinical Immunology 2021, 232: 108857. PMID: 34560283, PMCID: PMC8455237, DOI: 10.1016/j.clim.2021.108857.
- Shin JJ, Catanzaro J, Yonkof JR, Delmonte O, Sacco K, Shin MS, Reddy S, Whittington PJ, Soffer G, Mustillo PJ, Sullivan KE, Notarangelo LD, Abraham RS, Romberg N, Kang I. Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients. Journal Of Clinical Immunology 2021, 41: 795-806. PMID: 33495902, PMCID: PMC8329305, DOI: 10.1007/s10875-021-00968-x.
- Azar MM, Shin JJ, Kang I, Landry M. Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome. Expert Review Of Molecular Diagnostics 2020, 20: 1087-1097. PMID: 32990479, DOI: 10.1080/14737159.2020.1830760.
- Shin JJ, Liauw D, Siddiqui S, Lee J, Chung EJ, Steele R, Hsu FI, Price C, Kang I. Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum. Journal Of Clinical Immunology 2020, 40: 592-601. PMID: 32239366, PMCID: PMC7260109, DOI: 10.1007/s10875-020-00773-y.
- Shin J, Liauw D, Siddiqui S, Chung E, Price C, Kang I. Association of various primary antibody deficiencies with unique clinical manifestations and T cell profiles. Journal Of Allergy And Clinical Immunology 2020, 145: ab217. DOI: 10.1016/j.jaci.2019.12.257.
- Michailidou D, Shin J, Forde I, Gopalratnam K, Cohen P, DeGirolamo A. Typical evanescent and atypical persistent polymorphic cutaneous rash in an adult Brazilian with Still’s disease: a case report and review of the literature. Autoimmunity Highlights 2015, 6: 39-46. PMID: 26423534, PMCID: PMC4633415, DOI: 10.1007/s13317-015-0071-9.
- Strle K, Shin JJ, Glickstein LJ, Steere AC. Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis. Arthritis And Rheumatism 2012, 64: 1497-507. PMID: 22246581, PMCID: PMC3338893, DOI: 10.1002/art.34383.
- Shen S, Shin JJ, Strle K, McHugh G, Li X, Glickstein LJ, Drouin EE, Steere AC. Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis. Arthritis And Rheumatism 2010, 62: 2127-37. PMID: 20506317, PMCID: PMC2913315, DOI: 10.1002/art.27468.
- Shin JJ, Strle K, Glickstein LJ, Luster AD, Steere AC. Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis. Arthritis Research & Therapy 2010, 12: R168. PMID: 20828409, PMCID: PMC2990995, DOI: 10.1186/ar3128.
- Müllegger RR, Means TK, Shin JJ, Lee M, Jones KL, Glickstein LJ, Luster AD, Steere AC. Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma. Infection And Immunity 2007, 75: 4621-8. PMID: 17606602, PMCID: PMC1951170, DOI: 10.1128/IAI.00263-07.
- Shin JJ, Glickstein LJ, Steere AC. High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis. Arthritis And Rheumatism 2007, 56: 1325-35. PMID: 17393419, DOI: 10.1002/art.22441.
- Zuñiga J, Lillo L, Shin JJ, Machavarapu RL, Quiroga T, Goycoolea M, Matsuhiro B, Aron-Hott L, Godfrey HP, Cabello FC. Salmonella enterica serovar Typhi O:1,9,12 polysaccharide-protein conjugate as a diagnostic tool for typhoid fever. Journal Of Clinical Microbiology 2005, 43: 4545-50. PMID: 16145105, PMCID: PMC1234140, DOI: 10.1128/JCM.43.9.4545-4550.2005.
- Ballabh P, Kumari J, Krauss AN, Shin JJ, Jain A, Auld PA, Lesser ML, Cunningham-Rundles S. Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone. Pediatrics 2003, 111: 461-8. PMID: 12612222.
Departments and Programs
Titles
- Assistant Professor
Education & Training
- Clinical FellowYale University School of Medicine (2020)
- ResidencyYale New Haven Health - Bridgeport Hospital (2017)
- MDRoss University School of Medicine
- Post doctoral research fellowMassachusetts General Hospital - Harvard Medical School (2010)
- PhDNew York Medical College, Microbiology and Immunology
Additional Information
Honors & Recognitions
- Immunodeficiency Foundation research award: Immunodeficiency Foundation (2023)
- HyperIgM Foundation research award: Hyper IgM Foundation (2022)
- Federation of Clinical Immunology Societies Research Award: Federation of Clinical Immunology Societies (2021)
- Yale Center for Clinical Investigation Scholar: Yale University School of Medicine (2021)
- First place, oral presentation : Education and Research Day of Yale New Haven Health (2015)
- Graduate Faculty Council Award: New York Medical College (2005)
- Scholarship for the study of Lyme disease 1994: Walter J. and Lille A. Berbecker Foundation (2005)
Publications
- Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, You S, Racke M, Bucala R, Kang I. Modulating IL-1β and its receptors shapes spike-specific CD4 +T cell responses to mRNA vaccination. The Journal Of Immunology 2023, 210: 159.20-159.20. DOI: 10.4049/jimmunol.210.supp.159.20.
- Ünlü S, Shin J, Par-Young J, Simonov M, Vinetz J, Petrylak D, Kang I, Kim J. Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients. Cancer Investigation 2022, 41: 77-83. PMID: 36373994, DOI: 10.1080/07357907.2022.2139839.
- Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a Common Genetic Determinant of COVID-19 Symptomatic Infection and Severity. QJM 2022, 116: hcac234. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.
- Shin JJ, Par-Young J, Unlu S, McNamara A, Park HJ, Shin MS, Gee RJ, Doyle H, Afinogenova Y, Zidan E, Kwah J, Russo A, Mamula M, Hsu FI, Catanzaro J, Racke M, Bucala R, Wilen C, Kang I. Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency. Journal Of Clinical Immunology 2022, 42: 1137-1150. PMID: 35713752, PMCID: PMC9203263, DOI: 10.1007/s10875-022-01296-4.
- Unlu S, Shin J, Par-Young J, Vinetz J, Petrylak D, Kang I, Kim J. Effect of androgen receptor directed therapy in prostate cancer patients with COVID-19. Journal Of Clinical Oncology 2022, 40: 161-161. DOI: 10.1200/jco.2022.40.6_suppl.161.
- Shin J, Kaman K, Anthonypillai J, Soffer G, Kang I. Peripheral Blood Cell Counts Predict Distinct Endoscopic Phenotypes In Eosinophilic Esophagitis. Journal Of Allergy And Clinical Immunology 2022, 149: ab204. DOI: 10.1016/j.jaci.2021.12.670.
- Kuster JK, Unlu S, Makin TA, Par-Young J, Simonov M, Shafi S, Balanda M, Randolph C, Steele R, Hsu FI, Price C, Kohli-Pamnani A, Borish L, Lawrence MG, Kang I, Shin JJ. Low IgG trough and lymphocyte subset counts are associated with hospitalization for COVID-19 in patients with primary antibody deficiency. The Journal Of Allergy And Clinical Immunology In Practice 2021, 10: 633-636.e3. PMID: 34929372, PMCID: PMC8683251, DOI: 10.1016/j.jaip.2021.11.030.
- Shin JJ, Jeon S, Unlu S, Par-Young J, Shin MS, Kuster JK, Afinogenova Y, Kang Y, Simonov M, Buller G, Bucala R, Kang I. A distinct association of inflammatory molecules with outcomes of COVID-19 in younger versus older adults. Clinical Immunology 2021, 232: 108857. PMID: 34560283, PMCID: PMC8455237, DOI: 10.1016/j.clim.2021.108857.
- Shin JJ, Catanzaro J, Yonkof JR, Delmonte O, Sacco K, Shin MS, Reddy S, Whittington PJ, Soffer G, Mustillo PJ, Sullivan KE, Notarangelo LD, Abraham RS, Romberg N, Kang I. Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients. Journal Of Clinical Immunology 2021, 41: 795-806. PMID: 33495902, PMCID: PMC8329305, DOI: 10.1007/s10875-021-00968-x.
- Azar MM, Shin JJ, Kang I, Landry M. Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome. Expert Review Of Molecular Diagnostics 2020, 20: 1087-1097. PMID: 32990479, DOI: 10.1080/14737159.2020.1830760.
- Shin JJ, Liauw D, Siddiqui S, Lee J, Chung EJ, Steele R, Hsu FI, Price C, Kang I. Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum. Journal Of Clinical Immunology 2020, 40: 592-601. PMID: 32239366, PMCID: PMC7260109, DOI: 10.1007/s10875-020-00773-y.
- Shin J, Liauw D, Siddiqui S, Chung E, Price C, Kang I. Association of various primary antibody deficiencies with unique clinical manifestations and T cell profiles. Journal Of Allergy And Clinical Immunology 2020, 145: ab217. DOI: 10.1016/j.jaci.2019.12.257.
- Michailidou D, Shin J, Forde I, Gopalratnam K, Cohen P, DeGirolamo A. Typical evanescent and atypical persistent polymorphic cutaneous rash in an adult Brazilian with Still’s disease: a case report and review of the literature. Autoimmunity Highlights 2015, 6: 39-46. PMID: 26423534, PMCID: PMC4633415, DOI: 10.1007/s13317-015-0071-9.
- Strle K, Shin JJ, Glickstein LJ, Steere AC. Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis. Arthritis And Rheumatism 2012, 64: 1497-507. PMID: 22246581, PMCID: PMC3338893, DOI: 10.1002/art.34383.
- Shen S, Shin JJ, Strle K, McHugh G, Li X, Glickstein LJ, Drouin EE, Steere AC. Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis. Arthritis And Rheumatism 2010, 62: 2127-37. PMID: 20506317, PMCID: PMC2913315, DOI: 10.1002/art.27468.
- Shin JJ, Strle K, Glickstein LJ, Luster AD, Steere AC. Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis. Arthritis Research & Therapy 2010, 12: R168. PMID: 20828409, PMCID: PMC2990995, DOI: 10.1186/ar3128.
- Müllegger RR, Means TK, Shin JJ, Lee M, Jones KL, Glickstein LJ, Luster AD, Steere AC. Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma. Infection And Immunity 2007, 75: 4621-8. PMID: 17606602, PMCID: PMC1951170, DOI: 10.1128/IAI.00263-07.
- Shin JJ, Glickstein LJ, Steere AC. High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis. Arthritis And Rheumatism 2007, 56: 1325-35. PMID: 17393419, DOI: 10.1002/art.22441.
- Zuñiga J, Lillo L, Shin JJ, Machavarapu RL, Quiroga T, Goycoolea M, Matsuhiro B, Aron-Hott L, Godfrey HP, Cabello FC. Salmonella enterica serovar Typhi O:1,9,12 polysaccharide-protein conjugate as a diagnostic tool for typhoid fever. Journal Of Clinical Microbiology 2005, 43: 4545-50. PMID: 16145105, PMCID: PMC1234140, DOI: 10.1128/JCM.43.9.4545-4550.2005.
- Ballabh P, Kumari J, Krauss AN, Shin JJ, Jain A, Auld PA, Lesser ML, Cunningham-Rundles S. Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone. Pediatrics 2003, 111: 461-8. PMID: 12612222.
Departments and Programs