- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Smilow Cancer Hospital Prostate and Urologic Cancers ProgramSmilow Cancer Hospital at North Haven6 Devine Street, Fl 2North Haven, CT 06473
Joseph Kim, MD
Biography
Joseph Kim, MD, is an associate professor at Yale School of Medicine and the director of Prostate Cancer Research at Yale Cancer Center. A Yale Medicine oncology specialist, he delivers compassionate, patient-centered, and evidence-based care for patients with genitourinary cancer including prostate cancer, bladder cancer, testicular cancer, and penile cancer. Dr. Kim offers advanced treatments, such as cancer immunotherapy and oral inhibitors based on genomic biomarkers for prostate cancer and bladder cancer.
His research interests encompass developing novel anti-cancer therapies for genitourinary cancers through early phase clinical trials. Dr. Kim's research also explores changes in tumor DNA during treatment for patients with advanced prostate cancer.
Dr. Kim's impactful research has been recognized through several awards, including the Young Investigator Award and the Merit Award from the Conque Cancer Foundation with the American Society of Clinical Oncology, as well as the Cancer Clinical Investigator Team Leadership Award from the National Cancer Institute.
Titles
- Associate Professor of Internal Medicine (Medical Oncology)
- Director, Prostate Cancer Research
- Lecture Coordinator in Hematology/Oncology, Yale Affiliated Hospital Program
Education & Training
- FellowNational Institutes of Health (2013)
- ResidentEmory University School of Medicine (2010)
- MDWake Forest University School of Medicine (2007)
- BACovenant College, Biology, Pre-Medicine (2001)
Languages Spoken
- English
- 한국어 (Korean)
Additional Information
- Cancer Clinical Investigator Team Leadership Award (CCITLA): NCI (2021)
- Young Investigator Award: Conquer Cancer Foundation, American Society of Clinical Oncology (2013)
- Merit Award: Conqer Cancer Foundation, American Society of Clinical Oncology (2013)
- ASCO-SEP (2021 - Present): Editor
- Frontiers Oncology (2019 - Present): Reviewer
- Current Oncology Reports (2015 - Present): Editor
- American Association for Cancer Research (2014 - Present): Member
- Society of Immunotherapy of Cancer (2013 - Present): Member
- American Society of Clinical Oncology (2010 - Present): Member
- Hu Y, Narayan A, Xu Y, Wolfe J, Vu D, Trinh T, Kantak C, Ivy S, Eder J, Deng Y, LoRusso P, Kim J, Patel A. Circulating Tumor DNA Dynamics Fail to Predict Efficacy of Poly(ADP-ribose) Polymerase/VEGFR Inhibition in Patients With Heavily Pretreated Advanced Solid Tumors. JCO Precision Oncology 2024, 8: e2300289. PMID: 38412387, PMCID: PMC10914240, DOI: 10.1200/po.23.00289.
- Ünlü S, Shin J, Par-Young J, Simonov M, Vinetz J, Petrylak D, Kang I, Kim J. Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients. Cancer Investigation 2022, 41: 77-83. PMID: 36373994, DOI: 10.1080/07357907.2022.2139839.
- Kim JW, McKay RR, Radke MR, Zhao S, Taplin ME, Davis NB, Monk P, Appleman LJ, Lara PN, Vaishampayan UN, Zhang J, Paul AK, Bubley G, Van Allen EM, Unlu S, Huang Y, Loda M, Shapiro GI, Glazer PM, LoRusso PM, Ivy SP, Shyr Y, Swisher EM, Petrylak DP. Randomized Trial of Olaparib With or Without Cediranib for Metastatic Castration-Resistant Prostate Cancer: The Results From National Cancer Institute 9984. Journal Of Clinical Oncology 2022, 41: 871-880. PMID: 36256912, PMCID: PMC9901975, DOI: 10.1200/jco.21.02947.
- Unlu S, Kim JW. Emerging Role of PARP Inhibitors in Metastatic Prostate Cancer. Current Oncology Reports 2022, 24: 1619-1631. PMID: 35931885, DOI: 10.1007/s11912-022-01305-0.
- Aapro M, Bossi P, Dasari A, Fallowfield L, Gascón P, Geller M, Jordan K, Kim J, Martin K, Porzig S. Digital Health for Optimal Supportive Care in Oncology: Benefits, Limits, and Future Perspectives. Kompass Nutrition & Dietetics 2021, 1: 72-90. DOI: 10.1159/000519151.
- Kim J, Cardin DB, Vaishampayan UN, Kato S, Grossman SR, Glazer P, Shyr Y, Ivy SP, LoRusso P. Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation. The Oncologist 2021, 26: e1104-e1109. PMID: 33742489, PMCID: PMC8265343, DOI: 10.1002/onco.13758.
- Petrylak DP, Loriot Y, Shaffer DR, Braiteh F, Powderly J, Harshman LC, Conkling P, Delord JP, Gordon M, Kim JW, Sarkar I, Yuen K, Kadel EE, Mariathasan S, O'Hear C, Narayanan S, Fassò M, Carroll S, Powles T. Safety and Clinical Activity of Atezolizumab in Patients with Metastatic Castration-Resistant Prostate Cancer: A Phase I StudyAtezolizumab in Castration-Resistant Prostate Cancer. Clinical Cancer Research 2021, 27: 3360-3369. PMID: 33568344, DOI: 10.1158/1078-0432.ccr-20-1981.
- Madan RA, Karzai FH, Al Harthy M, Petrylak DP, Kim JW, Arlen PM, Rosner I, Theoret MR, Cordes L, Bilusic M, Peer CJ, Dawson NA, Couvillon A, Hankin A, Williams M, Chun G, Owens H, Marte JL, Lee M, Tomita Y, Yuno A, Trepel JB, Lee S, Steinberg SM, Gulley JL, Figg WD, Dahut WL. Cabozantinib plus docetaxel and prednisone in metastatic castration‐resistant prostate cancer. BJU International 2020, 127: 435-444. PMID: 32969563, PMCID: PMC8265825, DOI: 10.1111/bju.15227.
- Aapro M, Bossi P, Dasari A, Fallowfield L, Gascón P, Geller M, Jordan K, Kim J, Martin K, Porzig S. Digital health for optimal supportive care in oncology: benefits, limits, and future perspectives. Supportive Care In Cancer 2020, 28: 4589-4612. PMID: 32533435, PMCID: PMC7447627, DOI: 10.1007/s00520-020-05539-1.
- Somaiah N, Chawla SP, Block MS, Morris JC, Do K, Kim JW, Druta M, Sankhala KK, Hwu P, Jones RL, Gnjatic S, Kim-Schulze S, Tuballes K, Yishak M, Lu H, Yakovich A, Meulen J, Chen M, Kenney RT, Bohac C, Pollack SM. A Phase 1b Study Evaluating the Safety, Tolerability, and Immunogenicity of CMB305, a Lentiviral-Based Prime-Boost Vaccine Regimen, in Patients with Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1. OncoImmunology 2020, 9: 1847846. PMID: 33312760, PMCID: PMC7714520, DOI: 10.1080/2162402x.2020.1847846.
- Somaiah N, Block MS, Kim JW, Shapiro GI, T. K, Hwu P, Eder J, Jones RL, Lu H, Meulen J, Bohac C, Chen M, Hsu FJ, Gnjatic S, Pollack SM. First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1. Clinical Cancer Research 2019, 25: 5808-5817. PMID: 31227504, DOI: 10.1158/1078-0432.ccr-19-1025.
- Shin MS, Yim K, Moon K, Park HJ, Mohanty S, Kim JW, Montgomery RR, Shaw AC, Krishnaswamy S, Kang I. Dissecting alterations in human CD8+ T cells with aging by high-dimensional single cell mass cytometry. Clinical Immunology 2019, 200: 24-30. PMID: 30659916, PMCID: PMC6443094, DOI: 10.1016/j.clim.2019.01.005.
- Strauss J, Heery CR, Kim JW, Jochems C, Donahue RN, Montgomery AS, McMahon S, Lamping E, Marté J, Madan RA, Bilusic M, Silver MR, Bertotti E, Schlom J, Gulley JL. First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors. Clinical Cancer Research 2019, 25: 99-109. PMID: 30131389, PMCID: PMC6320276, DOI: 10.1158/1078-0432.ccr-18-1512.
- Janjigian YY, Bendell J, Calvo E, Kim JW, Ascierto PA, Sharma P, Ott PA, Peltola K, Jaeger D, Evans J, de Braud F, Chau I, Harbison CT, Dorange C, Tschaika M, Le DT. CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer. Journal Of Clinical Oncology 2018, 36: 2836-2844. PMID: 30110194, PMCID: PMC6161834, DOI: 10.1200/jco.2017.76.6212.
- Petrylak DP, Powles T, Bellmunt J, Braiteh F, Loriot Y, Morales-Barrera R, Burris HA, Kim JW, Ding B, Kaiser C, Fassò M, O’Hear C, Vogelzang NJ. Atezolizumab (MPDL3280A) Monotherapy for Patients With Metastatic Urothelial Cancer: Long-term Outcomes From a Phase 1 Study. JAMA Oncology 2018, 4: 537-544. PMID: 29423515, PMCID: PMC5885219, DOI: 10.1001/jamaoncol.2017.5440.
- Strauss J, Heery C, Schlom J, Madan R, Cao L, Kang Z, Lamping E, Marté J, Donahue R, Grenga I, Cordes L, Christensen O, Mahnke L, Helwig C, Gulley J. Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors. Clinical Cancer Research 2018, 24: 1287-1295. PMID: 29298798, PMCID: PMC7985967, DOI: 10.1158/1078-0432.ccr-17-2653.
- Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor BrachyuryHeery C, Palena C, McMahon S, Donahue R, Lepone L, Grenga I, Dirmeier U, Cordes L, Marté J, Dahut W, Singh H, Madan R, Fernando R, Hamilton D, Schlom J, Gulley J. Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury. Clinical Cancer Research 2017, 23: 6833-6845. PMID: 28855356, PMCID: PMC5690815, DOI: 10.1158/1078-0432.ccr-17-1087.
- Grenga I, Donahue R, Gargulak M, Lepone L, Roselli M, Bilusic M, Schlom J. Anti-PD-L1/TGFβR2 (M7824) fusion protein induces immunogenic modulation of human urothelial carcinoma cell lines, rendering them more susceptible to immune-mediated recognition and lysis. Urologic Oncology Seminars And Original Investigations 2017, 36: 93.e1-93.e11. PMID: 29103968, PMCID: PMC5835162, DOI: 10.1016/j.urolonc.2017.09.027.
- Kim JW, Shin MS, Kang Y, Kang I, Petrylak DP. Immune Analysis of Radium-223 in Patients With Metastatic Prostate Cancer. Clinical Genitourinary Cancer 2017, 16: e469-e476. PMID: 29137877, PMCID: PMC5878980, DOI: 10.1016/j.clgc.2017.10.010.
- Ascierto PA, Daniele B, Hammers H, Hirsh V, Kim J, Licitra L, Nanda R, Pignata S. Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge”, Napoli, November 30th 2016. Journal Of Translational Medicine 2017, 15: 205. PMID: 29020960, PMCID: PMC5637331, DOI: 10.1186/s12967-017-1309-2.
- Heery C, O'Sullivan-Coyne G, Madan R, Cordes L, Rajan A, Rauckhorst M, Lamping E, Oyelakin I, Marté J, Lepone L, Donahue R, Grenga I, Cuillerot J, Neuteboom B, von Heydebreck A, Chin K, Schlom J, Gulley J. Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial. The Lancet Oncology 2017, 18: 587-598. PMID: 28373007, PMCID: PMC6387686, DOI: 10.1016/s1470-2045(17)30239-5.
- Donahue R, Lepone L, Grenga I, Jochems C, Fantini M, Madan R, Heery C, Gulley J, Schlom J. Analyses of the peripheral immunome following multiple administrations of avelumab, a human IgG1 anti-PD-L1 monoclonal antibody. Journal For ImmunoTherapy Of Cancer 2017, 5: 20. PMID: 28239472, PMCID: PMC5320726, DOI: 10.1186/s40425-017-0220-y.
- Ager C, Reilley M, Nicholas C, Bartkowiak T, Jaiswal A, Curran M, Albershardt T, Bajaj A, Archer J, Reeves R, Ngo L, Berglund P, ter Meulen J, Denis C, Ghadially H, Arnoux T, Chanuc F, Fuseri N, Wilkinson R, Wagtmann N, Morel Y, Andre P, Atkins M, Carlino M, Ribas A, Thompson J, Choueiri T, Hodi F, Hwu W, McDermott D, Atkinson V, Cebon J, Fitzharris B, Jameson M, McNeil C, Hill A, Mangin E, Ahamadi M, van Vugt M, van Zutphen M, Ibrahim N, Long G, Gartrell R, Blake Z, Simoes I, Fu Y, Saito T, Qian Y, Lu Y, Saenger Y, Budhu S, De Henau O, Zappasodi R, Schlunegger K, Freimark B, Hutchins J, Barker C, Wolchok J, Merghoub T, Burova E, Allbritton O, Hong P, Dai J, Pei J, Liu M, Kantrowitz J, Lai V, Poueymirou W, MacDonald D, Ioffe E, Mohrs M, Olson W, Thurston G, Capasso C, Frascaro F, Carpi S, Tähtinen S, Feola S, Fusciello M, Peltonen K, Martins B, Sjöberg M, Pesonen S, Ranki T, Kyruk L, Ylösmäki E, Cerullo V, Cerignoli F, Xi B, Guenther G, Yu N, Muir L, Zhao L, Abassi Y, 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Marraco S, Speiser D, Abraham T, Xiang B, Magee M, Waldman S, Snook A, Blogowski W, Zuba-Surma E, Budkowska M, Salata D, Dolegowska B, Starzynska T, Chan L, Somanchi S, McCulley K, Lee D, Buettner N, Shi F, Myers P, Curbishley S, Penny S, Steadman L, Millar D, Speers E, Ruth N, Wong G, Thimme R, Adams D, Cobbold M, Thomas R, Hendrickx W, Al-Muftah M, Decock J, Wong M, Morse M, McDermott D, Clark J, Kaufman H, Daniels G, Hua H, Rao T, Dutcher J, Kang K, Saunthararajah Y, Velcheti V, Kumar V, Anwar F, Verma A, Chheda Z, Kohanbash G, Sidney J, Okada K, Shrivastav S, Carrera D, Liu S, Jahan N, Mueller S, Pollack I, Carcaboso A, Sette A, Hou Y, Okada H, Field J, Zeng W, Shih V, Law C, Senter P, Gardai S, Okeley N, Penny S, Abelin J, Saeed A, Malaker S, Myers P, Shabanowitz J, Ward S, Hunt D, Cobbold M, Profusek P, Wood L, Shepard D, Grivas P, Kapp K, Volz B, Oswald D, Wittig B, Schmidt M, Sefrin J, Hillringhaus L, Lifke V, Lifke A, Skaletskaya A, Ponte J, Chittenden T, Setiady Y, Valsesia-Wittmann S, Sivado E, Thomas V, El Alaoui M, Papot S, Dumontet C, Dyson M, McCafferty J, El Alaoui S, Verma A, Kumar V, Bommareddy P, Kaufman H, Zloza A, Kohlhapp F, Silk A, Jhawar S, Paneque T, Bommareddy P, Kohlhapp F, Newman J, Beltran P, Zloza A, Kaufman H, Cao F, Hong B, Rodriguez-Cruz T, Song X, Gottschalk S, Calderon H, Illingworth S, Brown A, Fisher K, Seymour L, Champion B, Eriksson E, Wenthe J, Hellström A, Paul-Wetterberg G, Loskog A, Eriksson E, Milenova I, Wenthe J, Ståhle M, Jarblad-Leja J, Ullenhag G, Dimberg A, Moreno R, Alemany R, Loskog A, Eriksson E, Milenova I, Moreno R, Alemany R, Loskog A, Jhawar S, Goyal S, Bommareddy P, Paneque T, Kaufman H, Zloza A, Kaufman H, Silk A, Mehnert J, Gabrail N, Bryan J, Medina D, Bommareddy P, Shafren D, Grose M, Zloza A, Mitchell L, Yagiz K, Lopez F, Mendoza D, Munday A, Gruber H, Jolly D, Fuhrmann S, Radoja S, Tan W, Pourchet A, Frey A, Mohr I, Mulvey M, Ranki T, Pesonen S, Capasso C, Ylösmäki E, Cerullo V, Andtbacka R, Ross M, Agarwala S, Grossmann K, Taylor M, Vetto J, Neves R, Daud A, Khong H, Meek S, Ungerleider R, Welden S, Tanaka M, Williams M, Andtbacka R, Curti B, Hallmeyer S, Fox B, Feng Z, Paustian C, Bifulco C, Grose M, Shafren D, Zafar S, Parviainen S, Siurala M, Hemminki O, Havunen R, Tähtinen S, Bramante S, Vassilev L, Wang H, Lieber A, Hemmi S, de Gruijl T, Kanerva A, Hemminki A, Ansari T, Sundararaman S, Roen D, Lehmann P, Bloom A, Bender L, Walters I, Terabe M, Berzofsky J, Chapelin F, Okada H, Ahrens E, DeFalco J, Harbell M, Manning-Bog A, Scholz A, Zhang D, Baia G, Tan Y, Sokolove J, Kim D, Williamson K, Chen X, Colrain J, Santo G, Nguyen N, Volkmuth W, Greenberg N, Robinson W, Emerling D, Drake C, Petrylak D, Antonarakis E, Kibel A, Chang N, Vu T, Campogan D, Haynes H, Trager J, Sheikh N, Quinn D, Kirk P, Addepalli M, Chang T, Zhang P, Konakova M, Hagihara K, Pai S, VanderVeen L, Obalapur P, Kuo P, Quach P, Fong L, Charych D, Zalevsky J, Langowski J, Addepalli M, Kirksey Y, Nutakki R, Kolarkar S, Pena R, Hoch U, Zalevsky J, Doberstein S, Charych D, Cha J, Mallon Z, Perez M, McDaniel A, Anand S, Uecker D, Nuccitelli R, McDaniel A, Anand S, Cha J, Uecker D, Nuccitelli R, Obermajer N, Urban J, Wieckowski E, Muthuswamy R, Ravindranathan R, Bartlett D, Kalinski P, Renrick A, Thounaojam M, Thomas P, Pellom S, Shanker A, Pellom S, Thounaojam M, Dudimah D, Brooks A, Sayers T, Shanker A, Su Y, Adamus T, Zhang Q, Nechaev S, Kortylewski M, Wei S, Allison J, Anderson C, Tang C, Schoenhals J, Tsouko E, Heymach J, de Groot P, Chang J, Hess K, Diab A, Sharma P, Allison J, Naing A, Hong D, Welsh J, Albershardt T, Parsons A, Leleux J, Reeves R, ter Meulen J, Berglund P, Ascarateil S, Koziol M, Penny S, Malaker S, Steadman L, Myers P, Bai D, Shabanowitz J, Hunt D, Cobbold M, Dai P, Wang W, Yang N, Shuman S, Merghoub T, Wolchok J, Deng L, Dillon P, Petroni G, Brenin D, Bullock K, Olson W, Smolkin M, Smith K, Nail C, Slingluff C, Sharma M, Fa’ak F, Janssen L, Khong H, Xiao Z, Hailemichael Y, Singh M, Vianden C, Diab A, Zalevsky J, Hoch U, Overwijk W, Facciabene A, Stefano P, Chongyung F, Rafail S, Hailemichael Y, Nielsen M, Fa’ak F, Vanderslice P, Woodside D, Market R, Biediger R, Marathi U, Overwijk W, Hollevoet K, Geukens N, Declerck P, Joly N, McIntosh L, Paramithiotis E, Rizell M, Sternby M, Andersson B, Karlsson-Parra A, Kuai R, Ochyl L, Schwendeman A, Moon J, Deng W, Hudson T, Lemmens E, Hanson B, Rae C, Burrill J, Skoble J, Katibah G, Murphy A, deVries M, Brockstedt D, Leong M, Lauer P, Dubensky T, Whiting C, Chen X, Hu Y, Xia Y, Zhou L, Bao Y, Huang S, Ren X, Hurt E, Hollingsworth R, Chang A, Wicha M, Li Q, Aggarwal C, Mangrolia D, Cohen R, Weinstein G, Morrow M, Bauml J, Kraynyak K, Boyer J, Yan J, Lee J, Humeau L, Oyola S, Duff S, Weiner D, Yang Z, Bagarazzi M, McNeel D, Eickhoff J, Jeraj R, Staab M, Straus J, Rekoske B, Liu G, Melssen M, Petroni G, Grosh W, Varhegyi N, Bullock K, Smolkin M, Smith K, Galeassi N, Deacon D, Gaughan E, Slingluff C, Ghisoli M, Barve M, Mennel R, Wallraven G, Manning L, Senzer N, Nemunaitis J, Ogasawara M, Ota S, Peace K, Hale D, Vreeland T, Jackson D, Berry J, Trappey A, Herbert G, Clifton G, Hardin M, Toms A, Qiao N, Litton J, Peoples G, Mittendorf E, Ghamsari L, Flano E, Jacques J, Liu B, Havel J, Makarov V, Merghoub T, Wolchok J, Hellmann M, Chan T, Flechtner J, Stefano P, Facciabene A, Facciponte J, Ugel S, De Sanctis F, Coukos G, Paris S, Pottier A, Levy L, Lu B, Cappuccini F, Pollock E, Bryant R, Hamdy F, Hill A, Redchenko I, Sultan H, Kumai T, Fesenkova V, Celis E, Tsang K, Fantini M, Fernando I, Palena C, David J, Hodge J, Gabitzsch E, Jones F, Gulley J, Schlom J, Herranz M, Rafail S, Ugel S, Facciponte J, Stefano P, Facciabene A, Wada H, Shimizu A, Osada T, Fukaya S, Sasaki E, Abolhalaj M, Askmyr D, Lundberg K, Albrekt A, Greiff L, Lindstedt M, Flies D, Higuchi T, Ornatowski W, Harris J, Adams S, Aguilera T, Rafat M, Castellini L, Shehade H, Kariolis M, Jang D, vonEbyen R, Graves E, Ellies L, Rankin E, Koong A, Giaccia A, Ajina R, Wang S, Smith J, Pierobon M, Jablonski S, Petricoin E, Weiner L, Sherry L, Waller J, Anderson M, Bigley A, Bernatchez C, Haymaker C, Tannir N, Kluger H, Tetzlaff M, Jackson N, Gergel I, Tagliaferri M, Zalevsky J, Hoch U, Hwu P, Snzol M, Hurwitz M, Diab A, Barberi T, Martin A, Suresh R, Barakat D, Harris-Bookman S, Drake C, Friedman A, Berkey S, Downs-Canner S, Delgoffe G, Edwards R, Curiel T, Odunsi K, Bartlett D, Obermajer N, Bruno T, Moore B, Squalls O, Ebner P, Waugh K, Mitchell J, Franklin W, Merrick D, McCarter M, Palmer B, Kern J, Vignali D, Slansky J, Chan A, Qiu X, Fraser K, Jonas A, Ottoson N, Gordon K, Kangas T, Leonardo S, Ertelt K, Walsh R, Uhlik M, Graff J, Bose N, Gupta R, Mandloi N, Paul K, Patil A, Sathian R, Mohan A, Manoharan M, Chaudhuri A, Chen Y, Lin J, Ye Y, Xu C, Chen G, Guo Z, Komarov A, Chenchik A, Makhanov M, Frangou C, Zheng Y, Coltharp C, Unfricht D, Dilworth R, Fridman L, Liu L, Rajopadhye M, Miller P, Concha-Benavente F, Bauman J, Trivedi S, Srivastava R, Ohr J, Heron D, Duvvuri U, Kim S, Gooding W, Ferris R, Torrey H, Mera T, Okubo Y, Vanamee E, Foster R, Faustman D, Gartrell R, Stack E, Lu Y, Izaki D, Beck K, Jia D, Armenta P, White-Stern A, Fu Y, Blake Z, Marks D, Kaufman H, Taback B, Horst B, Saenger Y, Glickman L, Kanne D, Gauthier K, Desbien A, Francica B, Katibah G, Corrales L, Leong J, Sung L, Metchette K, Kasibhatla S, Pferdekamper A, Zheng L, Cho C, Feng Y, McKenna J, Tallarico J, Bender S, Ndubaku C, McWhirter S, Drake C, Gajewski T, Dubensky T, Gugel E, Bell C, Munk A, Muniz L, Bhardwaj N, Zhao F, Evans K, Xiao C, Holtzhausen A, Hanks B, Scholler N, Yin C, Van der Meijs P, Prantner A, Krejsa C, Smith L, Johnson B, Branstetter D, Stein P, Jaen J, Tan J, Chen A, Chen Y, Park T, Powers J, Sexton H, Xu G, Young S, Schindler U, Deng W, Klinke D, Komar H, Mace T, Serpa G, Elnaggar O, Conwell D, Hart P, Schmidt C, Dillhoff M, Jin M, Ostrowski M, Lesinski G, Koti M, Au K, Peterson N, Truesdell P, Reid-Schachter G, Graham C, Craig A, Francis J, Kotlan B, Balatoni T, Farkas E, Toth L, Ujhelyi M, Savolt A, Doleschall Z, Horvath S, Eles K, Olasz J, Csuka O, Kasler M, Liszkay G, Barnea E, Kumar S, Tsujikawa T, Blakely C, Flynn P, Goodman R, Bueno R, Sugarbaker D, Jablons D, Broaddus V, West B, Coussens L, Kunk P, Obeid J, Winters K, Pramoonjago P, Smolkin M, Stelow E, Bauer T, Slingluff C, Rahma O, Lamble A, Kosaka Y, Huang F, Saser K, Adams H, Tognon C, Laderas T, McWeeney S, Loriaux M, Tyner J, Druker B, Lind E, Liu Z, Lu S, Kane L, Ferris R, Liu Z, Shayan G, Lu S, Ferris R, Femel J, Tsujikawa T, Lane R, Booth J, Lund A, Melssen M, Rodriguez A, Slingluff C, Engelhard V, Metelli A, Wu B, Fugle C, Saleh R, Sun S, Wu J, Liu B, Li Z, Morris Z, Guy E, Heinze C, Kler J, Gressett M, Werner L, Gillies S, Korman A, Loibner H, Hank J, Rakhmilevich A, Harari P, Sondel P, Newman J, Zloza A, Huelsmann E, Broucek J, Kaufman H, Brech D, Straub T, Irmler M, Beckers J, Buettner F, Schaeffeler E, Schwab M, Noessner E, Anand S, McDaniel A, Cha J, Uecker D, Nuccitelli R, Ordentlich P, Wolfreys A, Da Costa A, Silva J, Crosby A, Staelens L, Craggs G, Cauvin A, Mason S, Paterson A, Lake A, Armet C, O’Connor R, Hill J, Normant E, Adam A, Biniszkiewicz D, Chappel S, Palombella V, Holland P, Powers J, Becker A, Chen A, Leleti M, Newcomb E, Sexton H, Schindler U, Tan J, Young S, Jaen J, Rapisuwon S, Radfar A, Gardner K, Gibney G, Atkins M, Rennier K, Crowder R, Wang P, Pachynski R, Carrero R, Rivas S, Beceren-Braun F, Anthony S, Schluns K, Sawant D, Chikina M, Yano H, Workman C, Vignali D, Salerno E, Bedognetti D, Mauldin I, Deacon D, Shea S, Pinczewski J, Obeid J, Coukos G, Wang E, Gajewski T, Marincola F, Slingluff C, Spranger S, Horton B, Gajewski T, Suzuki A, Leland P, Joshi B, Puri R, Sweis R, Bao R, Luke J, Gajewski T, Theodoraki M, Mogundo F, Edwards R, Kalinski P, Won H, Moreira D, Gao C, Zhao X, Duttagupta P, Jones J, D’Apuzzo M, Pal S, Kortylewski M. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two. Journal For ImmunoTherapy Of Cancer 2016, 4: 73. PMCID: PMC5123381, DOI: 10.1186/s40425-016-0173-6.
- Sharma P, Callahan MK, Bono P, Kim J, Spiliopoulou P, Calvo E, Pillai RN, Ott PA, de Braud F, Morse M, Le DT, Jaeger D, Chan E, Harbison C, Lin CS, Tschaika M, Azrilevich A, Rosenberg JE. Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial. The Lancet Oncology 2016, 17: 1590-1598. PMID: 27733243, PMCID: PMC5648054, DOI: 10.1016/s1470-2045(16)30496-x.
- Farsaci B, Donahue R, Grenga I, Lepone L, Kim P, Dempsey B, Siebert J, Ibrahim N, Madan R, Heery C, Gulley J, Schlom J. Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy. Cancer Immunology Research 2016, 4: 755-765. PMID: 27485137, PMCID: PMC5138028, DOI: 10.1158/2326-6066.cir-16-0037.
- Heery C, Madan R, Stein M, Stadler W, Di Paola R, Rauckhorst M, Steinberg S, Marté J, Chen C, Grenga I, Donahue R, Jochems C, Dahut W, Schlom J, Gulley J. Samarium-153-EDTMP (Quadramet ® ) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial. Oncotarget 2016, 7: 69014-69023. PMID: 27486817, PMCID: PMC5340090, DOI: 10.18632/oncotarget.10883.
- Grenga I, Donahue R, Lepone L, Richards J, Schlom J. A fully human IgG1 anti‐PD‐L1 MAb in an in vitro assay enhances antigen‐specific T‐cell responses. Clinical & Translational Immunology 2016, 5: e83. PMID: 27350882, PMCID: PMC4910121, DOI: 10.1038/cti.2016.27.
- Roselli M, Formica V, Cereda V, Jochems C, Richards J, Grenga I, Orlandi A, Ferroni P, Guadagni F, Schlom J. The association of clinical outcome and peripheral T-cell subsets in metastatic colorectal cancer patients receiving first-line FOLFIRI plus bevacizumab therapy. OncoImmunology 2016, 5: e1188243. PMID: 27622042, PMCID: PMC5006891, DOI: 10.1080/2162402x.2016.1188243.
- Jochems C, Fantini M, Fernando R, Kwilas A, Donahue R, Lepone L, Grenga I, Kim Y, Brechbiel M, Gulley J, Madan R, Heery C, Hodge J, Newton R, Schlom J, Tsang K. The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells. Oncotarget 2016, 7: 37762-37772. PMID: 27192116, PMCID: PMC5122347, DOI: 10.18632/oncotarget.9326.
- Lepone L, Donahue R, Grenga I, Metenou S, Richards J, Heery C, Madan R, Gulley J, Schlom J. Analyses of 123 Peripheral Human Immune Cell Subsets: Defining Differences with Age and between Healthy Donors and Cancer Patients Not Detected in Analysis of Standard Immune Cell Types. Journal Of Circulating Biomarkers 2016, 5 DOI: 10.33393/jcb.2016.2071.
- Apolo AB, Lindenberg L, Shih JH, Mena E, Kim JW, Park JC, Alikhani A, McKinney YY, Weaver J, Turkbey B, Parnes HL, Wood LV, Madan RA, Gulley JL, Dahut WL, Kurdziel KA, Choyke PL. Prospective Study Evaluating Na18F PET/CT in Predicting Clinical Outcomes and Survival in Advanced Prostate Cancer. Journal Of Nuclear Medicine 2016, 57: 886-892. PMID: 26795292, PMCID: PMC6599519, DOI: 10.2967/jnumed.115.166512.
- Lepone L, Donahue R, Grenga I, Metenou S, Richards J, Heery C, Madan R, Gulley J, Schlom J. Analyses of 123 Peripheral Human Immune Cell Subsets: Defining Differences with Age and between Healthy Donors and Cancer Patients Not Detected in Analysis of Standard Immune Cell Types. Journal Of Circulating Biomarkers 2016, 5: 5. PMID: 28936253, PMCID: PMC5548330, DOI: 10.5772/62322.
- Grenga I, Kwilas A, Donahue R, Farsaci B, Hodge J. Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack. Journal For ImmunoTherapy Of Cancer 2015, 3: 52. PMID: 26579226, PMCID: PMC4647578, DOI: 10.1186/s40425-015-0096-7.
- Heery C, Ibrahim N, Arlen P, Mohebtash M, Murray J, Koenig K, Madan R, McMahon S, Marté J, Steinberg S, Donahue R, Grenga I, Jochems C, Farsaci B, Folio L, Schlom J, Gulley J. Docetaxel Alone or in Combination With a Therapeutic Cancer Vaccine (PANVAC) in Patients With Metastatic Breast Cancer: A Randomized Clinical Trial. JAMA Oncology 2015, 1: 1087. PMID: 26291768, PMCID: PMC6622177, DOI: 10.1001/jamaoncol.2015.2736.
- Heery C, Singh B, Rauckhorst M, Marté J, Donahue R, Grenga I, Rodell T, Dahut W, Arlen P, Madan R, Schlom J, Gulley J. Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury. Cancer Immunology Research 2015, 3: 1248-1256. PMID: 26130065, PMCID: PMC4636967, DOI: 10.1158/2326-6066.cir-15-0119.
- Kim JW, Tomita Y, Trepel J, Apolo AB. Emerging immunotherapies for bladder cancer. Current Opinion In Oncology 2015, 27: 191-200. PMID: 25811346, PMCID: PMC7709951, DOI: 10.1097/cco.0000000000000177.
- Kim JW, Eder JP. Prospects for targeting PD-1 and PD-L1 in various tumor types. Oncology 2014, 28 Suppl 3: 15-28. PMID: 25387682.
- Kim JW, Bilusic M, Plimack ER. Mechanisms of immunotherapy resistance in mCRPC: identifying the enemy on the visceral metastatic battlefield. Oncology 2014, 28: 986-90. PMID: 25403631.
- Farsaci B, Donahue R, Coplin M, Grenga I, Lepone L, Molinolo A, Hodge J. Immune Consequences of Decreasing Tumor Vasculature with Antiangiogenic Tyrosine Kinase Inhibitors in Combination with Therapeutic Vaccines. Cancer Immunology Research 2014, 2: 1090-1102. PMID: 25092771, PMCID: PMC4221465, DOI: 10.1158/2326-6066.cir-14-0076.
- Apolo AB, Kim JW, Bochner BH, Steinberg SM, Bajorin DF, Kelly K, Agarwal PK, Koppie TM, Kaag MG, Quinn DI, Vogelzang NJ, Sridhar SS. Examining the management of muscle-invasive bladder cancer by medical oncologists in the United States11Funding source: The US Office of Management and Budget (0925-0046). Urologic Oncology Seminars And Original Investigations 2014, 32: 637-644. PMID: 24840869, PMCID: PMC6771274, DOI: 10.1016/j.urolonc.2013.12.012.
- Kim P, Jochems C, Grenga I, Donahue R, Tsang K, Gulley J, Schlom J, Farsaci B. Pan-Bcl-2 Inhibitor, GX15-070 (Obatoclax), Decreases Human T Regulatory Lymphocytes while Preserving Effector T Lymphocytes: A Rationale for Its Use in Combination Immunotherapy. The Journal Of Immunology 2014, 192: 2622-2633. PMID: 24516200, PMCID: PMC4122292, DOI: 10.4049/jimmunol.1301369.
- Farsaci B, Jochems C, Grenga I, Donahue R, Tucker J, Pinto P, Merino M, Heery C, Madan R, Gulley J, Schlom J. Identification by digital immunohistochemistry of intratumoral changes of immune infiltrates after vaccine in the absence of modifications of PBMC immune cell subsets. International Journal Of Cancer 2014, 135: 862-870. PMID: 24474335, PMCID: PMC6467468, DOI: 10.1002/ijc.28743.
- Kim JW, Bilusic M, Heery CJ, Madan RA. Therapeutic Cancer Vaccines in Prostate Cancer: The Quest for Intermediate Markers of Response. Cancers 2012, 4: 1229-1246. PMID: 24213505, PMCID: PMC3712729, DOI: 10.3390/cancers4041229.
- Kim JW, Marshall JL. Improving harmonious precision. Oncology 2012, 26: 949, 954. PMID: 23176007.
- Kim JW. ASCO beyond McCormick: perseverance, collaboration, mentorship. Community Oncology 2012, 9: 265. PMID: 23028260, PMCID: PMC3460519, DOI: 10.1016/j.cmonc.2012.07.004.
- Kim JW, Gulley JL. Poxviral vectors for cancer immunotherapy. Expert Opinion On Biological Therapy 2012, 12: 463-478. PMID: 22413824, PMCID: PMC3482162, DOI: 10.1517/14712598.2012.668516.
- Ferroni P, Martini F, Portarena I, Grenga I, Riondino S, La Farina F, Laudisi A, Guadagni F, Roselli M. Early changes of a novel APC-dependent thrombin generation assay during chemotherapy independently predict venous thromboembolism in cancer patients—a pilot study. Supportive Care In Cancer 2012, 20: 2713-2720. PMID: 22322591, DOI: 10.1007/s00520-012-1391-1.
- Kim JW, Madan RA, Gulley JL. Initial PSA Oscillations Precede Prolonged Stable Disease in a Patient Treated With a Therapeutic Cancer Vaccine. Clinical Genitourinary Cancer 2011, 10: 43-46. PMID: 22019260, PMCID: PMC3279569, DOI: 10.1016/j.clgc.2011.09.003.
- Martini F, Portarena I, Grenga I, Riondino S, Farina F, Laudisi A, Roselli M, Guadagni F, Ferroni P. An activated protein C-dependent thrombin generation assay predicts chemotherapy-associated venous thromboembolism in cancer patients. Thrombosis And Haemostasis 2011, 105: 931-932. PMID: 21359410, DOI: 10.1160/th10-11-0757.
- Formica V, Del Monte G, Giacchetti I, Grenga I, Giaquinto S, Fini M, Roselli M. Rehabilitation in Neuro-Oncology: A Meta-Analysis of Published Data and a Mono-Institutional Experience. Integrative Cancer Therapies 2010, 10: 119-126. PMID: 21196433, DOI: 10.1177/1534735410392575.
- Formica V, Palmirotta R, Del Monte G, Savonarola A, Ludovici G, De Marchis M, Grenga I, Schirru M, Guadagni F, Roselli M. Predictive value of VEGF gene polymorphisms for metastatic colorectal cancer patients receiving first-line treatment including fluorouracil, irinotecan, and bevacizumab. International Journal Of Colorectal Disease 2010, 26: 143-151. PMID: 21188390, DOI: 10.1007/s00384-010-1108-1.
- Pellegrino R, Formica V, Portarena I, Mariotti S, Grenga I, Del Monte G, Roselli M. Caregiver distress in the early phases of cancer. Anticancer Research 2010, 30: 4657-63. PMID: 21115920.
- Kim JW, Amin AR, Shin DM. Chemoprevention of Head and Neck Cancer with Green Tea Polyphenols. Cancer Prevention Research 2010, 3: 900-909. PMID: 20663981, PMCID: PMC2917478, DOI: 10.1158/1940-6207.capr-09-0131.
- Formica V, Massara M, Portarena I, Fiaschetti V, Grenga I, Del Vecchio Blanco G, Sileri P, Tosetto L, Skoulidis F, Pallone F, Roselli M. Role of CA19.9 in predicting bevacizumab efficacy for metastatic colorectal cancer patients. Cancer Biomarkers 2009, 5: 167-175. PMID: 19729826, PMCID: PMC12922835, DOI: 10.3233/cbm-2009-0101.
- Hicks AM, Riedlinger G, Willingham MC, Alexander-Miller MA, Von Kap-Herr C, Pettenati MJ, Sanders AM, Weir HM, Du W, Kim J, Simpson AJ, Old LJ, Cui Z. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 7753-7758. PMID: 16682640, PMCID: PMC1458507, DOI: 10.1073/pnas.0602382103.
- Limentani SA, Asher A, Heafner M, Kim JW, Fraser R. A phase I trial of surgery, Gliadel wafer implantation, and immediate postoperative carboplatin in combination with radiation therapy for primary anaplastic astrocytoma or glioblastoma multiforme. Journal Of Neuro-Oncology 2005, 72: 241-244. PMID: 15937647, DOI: 10.1007/s11060-004-2339-1.
- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Smilow Cancer Hospital Prostate and Urologic Cancers ProgramSmilow Cancer Hospital at North Haven6 Devine Street, Fl 2North Haven, CT 06473
Biography
Joseph Kim, MD, is an associate professor at Yale School of Medicine and the director of Prostate Cancer Research at Yale Cancer Center. A Yale Medicine oncology specialist, he delivers compassionate, patient-centered, and evidence-based care for patients with genitourinary cancer including prostate cancer, bladder cancer, testicular cancer, and penile cancer. Dr. Kim offers advanced treatments, such as cancer immunotherapy and oral inhibitors based on genomic biomarkers for prostate cancer and bladder cancer.
His research interests encompass developing novel anti-cancer therapies for genitourinary cancers through early phase clinical trials. Dr. Kim's research also explores changes in tumor DNA during treatment for patients with advanced prostate cancer.
Dr. Kim's impactful research has been recognized through several awards, including the Young Investigator Award and the Merit Award from the Conque Cancer Foundation with the American Society of Clinical Oncology, as well as the Cancer Clinical Investigator Team Leadership Award from the National Cancer Institute.
Titles
- Associate Professor of Internal Medicine (Medical Oncology)
- Director, Prostate Cancer Research
- Lecture Coordinator in Hematology/Oncology, Yale Affiliated Hospital Program
Education & Training
- FellowNational Institutes of Health (2013)
- ResidentEmory University School of Medicine (2010)
- MDWake Forest University School of Medicine (2007)
- BACovenant College, Biology, Pre-Medicine (2001)
Languages Spoken
- English
- 한국어 (Korean)
Additional Information
- Cancer Clinical Investigator Team Leadership Award (CCITLA): NCI (2021)
- Young Investigator Award: Conquer Cancer Foundation, American Society of Clinical Oncology (2013)
- Merit Award: Conqer Cancer Foundation, American Society of Clinical Oncology (2013)
- ASCO-SEP (2021 - Present): Editor
- Frontiers Oncology (2019 - Present): Reviewer
- Current Oncology Reports (2015 - Present): Editor
- American Association for Cancer Research (2014 - Present): Member
- Society of Immunotherapy of Cancer (2013 - Present): Member
- American Society of Clinical Oncology (2010 - Present): Member
- Hu Y, Narayan A, Xu Y, Wolfe J, Vu D, Trinh T, Kantak C, Ivy S, Eder J, Deng Y, LoRusso P, Kim J, Patel A. Circulating Tumor DNA Dynamics Fail to Predict Efficacy of Poly(ADP-ribose) Polymerase/VEGFR Inhibition in Patients With Heavily Pretreated Advanced Solid Tumors. JCO Precision Oncology 2024, 8: e2300289. PMID: 38412387, PMCID: PMC10914240, DOI: 10.1200/po.23.00289.
- Ünlü S, Shin J, Par-Young J, Simonov M, Vinetz J, Petrylak D, Kang I, Kim J. Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients. Cancer Investigation 2022, 41: 77-83. PMID: 36373994, DOI: 10.1080/07357907.2022.2139839.
- Kim JW, McKay RR, Radke MR, Zhao S, Taplin ME, Davis NB, Monk P, Appleman LJ, Lara PN, Vaishampayan UN, Zhang J, Paul AK, Bubley G, Van Allen EM, Unlu S, Huang Y, Loda M, Shapiro GI, Glazer PM, LoRusso PM, Ivy SP, Shyr Y, Swisher EM, Petrylak DP. Randomized Trial of Olaparib With or Without Cediranib for Metastatic Castration-Resistant Prostate Cancer: The Results From National Cancer Institute 9984. Journal Of Clinical Oncology 2022, 41: 871-880. PMID: 36256912, PMCID: PMC9901975, DOI: 10.1200/jco.21.02947.
- Unlu S, Kim JW. Emerging Role of PARP Inhibitors in Metastatic Prostate Cancer. Current Oncology Reports 2022, 24: 1619-1631. PMID: 35931885, DOI: 10.1007/s11912-022-01305-0.
- Aapro M, Bossi P, Dasari A, Fallowfield L, Gascón P, Geller M, Jordan K, Kim J, Martin K, Porzig S. Digital Health for Optimal Supportive Care in Oncology: Benefits, Limits, and Future Perspectives. Kompass Nutrition & Dietetics 2021, 1: 72-90. DOI: 10.1159/000519151.
- Kim J, Cardin DB, Vaishampayan UN, Kato S, Grossman SR, Glazer P, Shyr Y, Ivy SP, LoRusso P. Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation. The Oncologist 2021, 26: e1104-e1109. PMID: 33742489, PMCID: PMC8265343, DOI: 10.1002/onco.13758.
- Petrylak DP, Loriot Y, Shaffer DR, Braiteh F, Powderly J, Harshman LC, Conkling P, Delord JP, Gordon M, Kim JW, Sarkar I, Yuen K, Kadel EE, Mariathasan S, O'Hear C, Narayanan S, Fassò M, Carroll S, Powles T. Safety and Clinical Activity of Atezolizumab in Patients with Metastatic Castration-Resistant Prostate Cancer: A Phase I StudyAtezolizumab in Castration-Resistant Prostate Cancer. Clinical Cancer Research 2021, 27: 3360-3369. PMID: 33568344, DOI: 10.1158/1078-0432.ccr-20-1981.
- Madan RA, Karzai FH, Al Harthy M, Petrylak DP, Kim JW, Arlen PM, Rosner I, Theoret MR, Cordes L, Bilusic M, Peer CJ, Dawson NA, Couvillon A, Hankin A, Williams M, Chun G, Owens H, Marte JL, Lee M, Tomita Y, Yuno A, Trepel JB, Lee S, Steinberg SM, Gulley JL, Figg WD, Dahut WL. Cabozantinib plus docetaxel and prednisone in metastatic castration‐resistant prostate cancer. BJU International 2020, 127: 435-444. PMID: 32969563, PMCID: PMC8265825, DOI: 10.1111/bju.15227.
- Aapro M, Bossi P, Dasari A, Fallowfield L, Gascón P, Geller M, Jordan K, Kim J, Martin K, Porzig S. Digital health for optimal supportive care in oncology: benefits, limits, and future perspectives. Supportive Care In Cancer 2020, 28: 4589-4612. PMID: 32533435, PMCID: PMC7447627, DOI: 10.1007/s00520-020-05539-1.
- Somaiah N, Chawla SP, Block MS, Morris JC, Do K, Kim JW, Druta M, Sankhala KK, Hwu P, Jones RL, Gnjatic S, Kim-Schulze S, Tuballes K, Yishak M, Lu H, Yakovich A, Meulen J, Chen M, Kenney RT, Bohac C, Pollack SM. A Phase 1b Study Evaluating the Safety, Tolerability, and Immunogenicity of CMB305, a Lentiviral-Based Prime-Boost Vaccine Regimen, in Patients with Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1. OncoImmunology 2020, 9: 1847846. PMID: 33312760, PMCID: PMC7714520, DOI: 10.1080/2162402x.2020.1847846.
- Somaiah N, Block MS, Kim JW, Shapiro GI, T. K, Hwu P, Eder J, Jones RL, Lu H, Meulen J, Bohac C, Chen M, Hsu FJ, Gnjatic S, Pollack SM. First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1. Clinical Cancer Research 2019, 25: 5808-5817. PMID: 31227504, DOI: 10.1158/1078-0432.ccr-19-1025.
- Shin MS, Yim K, Moon K, Park HJ, Mohanty S, Kim JW, Montgomery RR, Shaw AC, Krishnaswamy S, Kang I. Dissecting alterations in human CD8+ T cells with aging by high-dimensional single cell mass cytometry. Clinical Immunology 2019, 200: 24-30. PMID: 30659916, PMCID: PMC6443094, DOI: 10.1016/j.clim.2019.01.005.
- Strauss J, Heery CR, Kim JW, Jochems C, Donahue RN, Montgomery AS, McMahon S, Lamping E, Marté J, Madan RA, Bilusic M, Silver MR, Bertotti E, Schlom J, Gulley JL. First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors. Clinical Cancer Research 2019, 25: 99-109. PMID: 30131389, PMCID: PMC6320276, DOI: 10.1158/1078-0432.ccr-18-1512.
- Janjigian YY, Bendell J, Calvo E, Kim JW, Ascierto PA, Sharma P, Ott PA, Peltola K, Jaeger D, Evans J, de Braud F, Chau I, Harbison CT, Dorange C, Tschaika M, Le DT. CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer. Journal Of Clinical Oncology 2018, 36: 2836-2844. PMID: 30110194, PMCID: PMC6161834, DOI: 10.1200/jco.2017.76.6212.
- Petrylak DP, Powles T, Bellmunt J, Braiteh F, Loriot Y, Morales-Barrera R, Burris HA, Kim JW, Ding B, Kaiser C, Fassò M, O’Hear C, Vogelzang NJ. Atezolizumab (MPDL3280A) Monotherapy for Patients With Metastatic Urothelial Cancer: Long-term Outcomes From a Phase 1 Study. JAMA Oncology 2018, 4: 537-544. PMID: 29423515, PMCID: PMC5885219, DOI: 10.1001/jamaoncol.2017.5440.
- Strauss J, Heery C, Schlom J, Madan R, Cao L, Kang Z, Lamping E, Marté J, Donahue R, Grenga I, Cordes L, Christensen O, Mahnke L, Helwig C, Gulley J. Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors. Clinical Cancer Research 2018, 24: 1287-1295. PMID: 29298798, PMCID: PMC7985967, DOI: 10.1158/1078-0432.ccr-17-2653.
- Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor BrachyuryHeery C, Palena C, McMahon S, Donahue R, Lepone L, Grenga I, Dirmeier U, Cordes L, Marté J, Dahut W, Singh H, Madan R, Fernando R, Hamilton D, Schlom J, Gulley J. Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury. Clinical Cancer Research 2017, 23: 6833-6845. PMID: 28855356, PMCID: PMC5690815, DOI: 10.1158/1078-0432.ccr-17-1087.
- Grenga I, Donahue R, Gargulak M, Lepone L, Roselli M, Bilusic M, Schlom J. Anti-PD-L1/TGFβR2 (M7824) fusion protein induces immunogenic modulation of human urothelial carcinoma cell lines, rendering them more susceptible to immune-mediated recognition and lysis. Urologic Oncology Seminars And Original Investigations 2017, 36: 93.e1-93.e11. PMID: 29103968, PMCID: PMC5835162, DOI: 10.1016/j.urolonc.2017.09.027.
- Kim JW, Shin MS, Kang Y, Kang I, Petrylak DP. Immune Analysis of Radium-223 in Patients With Metastatic Prostate Cancer. Clinical Genitourinary Cancer 2017, 16: e469-e476. PMID: 29137877, PMCID: PMC5878980, DOI: 10.1016/j.clgc.2017.10.010.
- Ascierto PA, Daniele B, Hammers H, Hirsh V, Kim J, Licitra L, Nanda R, Pignata S. Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge”, Napoli, November 30th 2016. Journal Of Translational Medicine 2017, 15: 205. PMID: 29020960, PMCID: PMC5637331, DOI: 10.1186/s12967-017-1309-2.
- Heery C, O'Sullivan-Coyne G, Madan R, Cordes L, Rajan A, Rauckhorst M, Lamping E, Oyelakin I, Marté J, Lepone L, Donahue R, Grenga I, Cuillerot J, Neuteboom B, von Heydebreck A, Chin K, Schlom J, Gulley J. Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial. The Lancet Oncology 2017, 18: 587-598. PMID: 28373007, PMCID: PMC6387686, DOI: 10.1016/s1470-2045(17)30239-5.
- Donahue R, Lepone L, Grenga I, Jochems C, Fantini M, Madan R, Heery C, Gulley J, Schlom J. Analyses of the peripheral immunome following multiple administrations of avelumab, a human IgG1 anti-PD-L1 monoclonal antibody. Journal For ImmunoTherapy Of Cancer 2017, 5: 20. PMID: 28239472, PMCID: PMC5320726, DOI: 10.1186/s40425-017-0220-y.
- Ager C, Reilley M, Nicholas C, Bartkowiak T, Jaiswal A, Curran M, Albershardt T, Bajaj A, Archer J, Reeves R, Ngo L, Berglund P, ter Meulen J, Denis C, Ghadially H, Arnoux T, Chanuc F, Fuseri N, Wilkinson R, Wagtmann N, Morel Y, Andre P, Atkins M, Carlino M, Ribas A, Thompson J, Choueiri T, Hodi F, Hwu W, McDermott D, Atkinson V, Cebon J, Fitzharris B, Jameson M, McNeil C, Hill A, Mangin E, Ahamadi M, van Vugt M, van Zutphen M, Ibrahim N, Long G, Gartrell R, Blake Z, Simoes I, Fu Y, Saito T, Qian Y, Lu Y, Saenger Y, Budhu S, De Henau O, Zappasodi R, Schlunegger K, Freimark B, Hutchins J, Barker C, Wolchok J, Merghoub T, Burova E, Allbritton O, Hong P, Dai J, Pei J, Liu M, Kantrowitz J, Lai V, Poueymirou W, MacDonald D, Ioffe E, Mohrs M, Olson W, Thurston G, Capasso C, Frascaro F, Carpi S, Tähtinen S, Feola S, Fusciello M, Peltonen K, Martins B, Sjöberg M, Pesonen S, Ranki T, Kyruk L, Ylösmäki E, Cerullo V, Cerignoli F, Xi B, Guenther G, Yu N, Muir L, Zhao L, Abassi Y, Cervera-Carrascón V, Siurala M, Santos J, Havunen R, Parviainen S, Hemminki A, Dalgleish A, Mudan S, DeBenedette M, Plachco A, Gamble A, Grogan E, Krisko J, Tcherepanova I, Nicolette C, Dhupkar P, Yu L, Kleinerman E, Gordon N, Grenga I, Lepone L, Gameiro S, Knudson K, Fantini M, Tsang K, Hodge J, Donahue R, Schlom J, Evans E, Bussler H, Mallow C, Reilly C, Torno S, Scrivens M, Foster C, Howell A, Balch L, Knapp A, Leonard J, Paris M, Fisher T, Hu-Lieskovan S, Ribas A, Smith E, Zauderer M, Fogler W, Franklin M, Thayer M, Saims D, Magnani J, Gong J, Gray M, Hutchins J, Freimark B, Fromm G, de Silva S, Giffin L, Xu X, Rose J, Schreiber T, Fantini M, Gameiro S, Knudson K, Clavijo P, Allen C, Donahue R, Lepone L, Grenga I, Hodge J, Tsang K, Schlom J, Gray M, Gong J, Hutchins J, Freimark B, Grogan J, Manieri N, Chiang E, Caplazi P, Yadav M, Hagner P, Chiu H, Waldman M, Klippel A, Thakurta A, Pourdehnad M, Gandhi A, Henrich I, Quick L, Young R, Chou M, Hotson A, Willingham S, Ho P, Choy C, Laport G, McCaffery I, Miller R, Tipton K, Wong K, Singson V, Wong C, Chan C, Huang Y, Liu S, Richardson J, Kavanaugh W, West J, Irving B, Tipton K, Wong K, Singson V, Wong C, Chan C, Huang Y, Liu S, Richardson J, Kavanaugh W, West J, Irving B, Jaini R, Loya M, Eng C, Johnson M, Adjei A, Opyrchal M, Ramalingam S, Janne P, Dominguez G, Gabrilovich D, de Leon L, Hasapidis J, Diede S, Ordentlich P, Cruickshank S, Meyers M, Hellmann M, Kalinski P, Zureikat A, Edwards R, Muthuswamy R, Obermajer N, Urban J, Butterfield L, Gooding W, Zeh H, Bartlett D, Zubkova O, Agapova L, Kapralova M, Krasovskaia L, Ovsepyan A, Lykov M, Eremeev A, Bokovanov V, Grigoryeva O, Karpov A, Ruchko S, Nicolette C, Shuster A, Khalil D, Campesato L, Li Y, Merghoub T, Wolchok J, Lazorchak A, Patterson T, Ding Y, Sasikumar P, Sudarshan N, Gowda N, Ramachandra R, Samiulla D, Giri S, Eswarappa R, Ramachandra M, Tuck D, Wyant T, Leshem J, Liu X, Bera T, Terabe M, Bossenmaier B, Niederfellner G, Reiter Y, Pastan I, Xia L, Xia Y, Hu Y, Wang Y, Bao Y, Dai F, Huang S, Hurt E, Hollingsworth R, Lum L, Chang A, Wicha M, Li Q, Mace T, Makhijani N, Talbert E, Young G, Guttridge D, Conwell D, Lesinski G, Gonzales R, Huffman A, Wang X, Reshef R, MacKinnon A, Chen J, Gross M, Marguier G, Shwonek P, Sotirovska N, Steggerda S, Parlati F, Makkouk A, Bennett M, Chen J, Emberley E, Gross M, Huang T, Li W, MacKinnon A, Marguier G, Neou S, Pan A, Zhang J, Zhang W, Parlati F, Marshall N, Marron T, Agudo J, Brown B, Brody J, McQuinn C, Mace T, Farren M, Komar H, Shakya R, Young G, Ludwug T, Lesinski G, Morillon Y, Hammond S, Schlom J, Greiner J, Nath P, Schwartz A, Maric D, Roberts D, Obermajer N, Bartlett D, Kalinski P, Naing A, Papadopoulos K, Autio K, Wong D, Patel M, Falchook G, Pant S, Ott P, Whiteside M, Patnaik A, Mumm J, Janku F, Chan I, Bauer T, Colen R, VanVlasselaer P, Brown G, Tannir N, Oft M, Infante J, Lipson E, Gopal A, Neelapu S, Armand P, Spurgeon S, Leonard J, Hodi F, Sanborn R, Melero I, Gajewski T, Maurer M, Perna S, Gutierrez A, Clynes R, Mitra P, Suryawanshi S, Gladstone D, Callahan M, Crooks J, Brown S, Gauthier A, de Boisferon M, MacDonald A, Brunet L, Rothwell W, Bell P, Wilson J, Sato-Kaneko F, Yao S, Zhang S, Carson D, Guiducci C, Coffman R, Kitaura K, Matsutani T, Suzuki R, Hayashi T, Cohen E, Schaer D, Li Y, Dobkin J, Amatulli M, Hall G, Doman T, Manro J, Dorsey F, Sams L, Holmgaard R, Persaud K, Ludwig D, Surguladze D, Kauh J, Novosiadly R, Kalos M, Driscoll K, Pandha H, Ralph C, Harrington K, Curti B, Sanborn R, Akerley W, Gupta S, Melcher A, Mansfield D, Kaufman D, Schmidt E, Grose M, Davies B, Karpathy R, Shafren D, Shamalov K, Cohen C, Sharma N, Allison J, Shekarian T, Valsesia-Wittmann S, Caux C, Marabelle A, Slomovitz B, Moore K, Youssoufian H, Posner M, Tewary P, Brooks A, Xu Y, Wijeratne K, Gunatilaka L, Sayers T, Vasilakos J, Alston T, Dovedi S, Elvecrog J, Grigsby I, Herbst R, Johnson K, Moeckly C, Mullins S, Siebenaler K, SternJohn J, Tilahun A, Tomai M, Vogel K, Wilkinson R, Vietsch E, Wellstein A, Wythes M, Crosignani S, Tumang J, Alekar S, Bingham P, Cauwenberghs S, Chaplin J, Dalvie D, Denies S, De Maeseneire C, Feng J, Frederix K, Greasley S, Guo J, Hardwick J, Kaiser S, Jessen K, Kindt E, Letellier M, Li W, Maegley K, Marillier R, Miller N, Murray B, Pirson R, Preillon J, Rabolli V, Ray C, Ryan K, Scales S, Srirangam J, Solowiej J, Stewart A, Streiner N, Torti V, Tsaparikos K, Zheng X, Driessens G, Gomes B, Kraus M, Xu C, Zhang Y, Kradjian G, Qin G, Qi J, Xu X, Marelli B, Yu H, Guzman W, Tighe R, Salazar R, Lo K, English J, Radvanyi L, Lan Y, Zappasodi R, Budhu S, Hellmann M, Postow M, Senbabaoglu Y, Gasmi B, Zhong H, Li Y, Liu C, Hirschhorhn-Cymerman D, Wolchok J, Merghoub T, Zha Y, Malnassy G, Fulton N, Park J, Stock W, Nakamura Y, Gajewski T, Liu H, Ju X, Kosoff R, Ramos K, Coder B, Petit R, Princiotta M, Perry K, Zou J, Arina A, Fernandez C, Zheng W, Beckett M, Mauceri H, Fu Y, Weichselbaum R, DeBenedette M, Lewis W, Gamble A, Nicolette C, Han Y, Wu Y, Yang C, Huang J, Wu D, Li J, Liang X, Zhou X, Hou J, Hassan R, Jahan T, Antonia S, Kindler H, Alley E, Honarmand S, Liu W, Leong M, Whiting C, Nair N, Enstrom A, Lemmens E, Tsujikawa T, Kumar S, Coussens L, Murphy A, Brockstedt D, Koch S, Sebastian M, Weiss C, Früh M, Pless M, Cathomas R, Hilbe W, Pall G, Wehler T, Alt J, Bischoff H, Geissler M, Griesinger F, Kollmeier J, Papachristofilou A, Doener F, Fotin-Mleczek M, Hipp M, Hong H, Kallen K, Klinkhardt U, Stosnach C, Scheel B, Schroeder A, Seibel T, Gnad-Vogt U, Zippelius A, Park H, Ahn Y, Kim T, Kim S, Kim S, Lee Y, Keam B, Kim D, Heo D, Pilon-Thomas S, Weber A, Morse J, Kodumudi K, Liu H, Mullinax J, Sarnaik A, Pike L, Bang A, Ott P, Balboni T, Taylor A, Spektor A, Wilhite T, Krishnan M, Cagney D, Alexander B, Aizer A, Buchbinder E, Awad M, Ghandi L, Hodi F, Schoenfeld J, Schwartz A, Nath P, Lessey-Morillon E, Ridnour L, Roberts D, Segal N, Sharma M, Le D, Ott P, Ferris R, Zelenetz A, Neelapu S, Levy R, Lossos I, Jacobson C, Ramchandren R, Godwin J, Colevas A, Meier R, Krishnan S, Gu X, Neely J, Suryawanshi S, Timmerman J, Vanpouille-Box C, Formenti S, Demaria S, Wennerberg E, Mediero A, Cronstein B, Formenti S, Demaria S, Gustafson M, DiCostanzo A, Wheatley C, Kim C, Bornschlegl S, Gastineau D, Johnson B, Dietz A, MacDonald C, Bucsek M, Qiao G, Hylander B, Repasky E, Turbitt W, Xu Y, Mastro A, Rogers C, Withers S, Wang Z, Khuat L, Dunai C, Blazar B, Longo D, Rebhun R, Grossenbacher S, Monjazeb A, Murphy W, Rowlinson S, Agnello G, Alters S, Lowe D, Scharping N, Menk A, Whetstone R, Zeng X, Delgoffe G, Santos P, Menk A, Shi J, Delgoffe G, Butterfield L, Whetstone R, Menk A, Scharping N, Delgoffe G, Nagasaka M, Sukari A, Byrne-Steele M, Pan W, Hou X, Brown B, Eisenhower M, Han J, Collins N, Manguso R, Pope H, Shrestha Y, Boehm J, Haining W, Cron K, Sivan A, Aquino-Michaels K, Gajewski T, Orecchioni M, Bedognetti D, Hendrickx W, Fuoco C, Spada F, Sgarrella F, Cesareni G, Marincola F, Kostarelos K, Bianco A, Delogu L, Hendrickx W, Roelands J, Boughorbel S, Decock J, Presnell S, Wang E, Marincola F, Kuppen P, Ceccarelli M, Rinchai D, Chaussabel D, Miller L, Bedognetti D, Nguyen A, Sanborn J, Vaske C, Rabizadeh S, Niazi K, Benz S, Patel S, Restifo N, White J, Angiuoli S, Sausen M, Jones S, Sevdali M, Simmons J, Velculescu V, Diaz L, Zhang T, Sims J, Barton S, Gartrell R, Kadenhe-Chiweshe A, Dela Cruz F, Turk A, Lu Y, Mazzeo C, Kung A, Bruce J, Saenger Y, Yamashiro D, Connolly E, Baird J, Crittenden M, Friedman D, Xiao H, Leidner R, Bell B, Young K, Gough M, Bian Z, Kidder K, Liu Y, Curran E, Chen X, Corrales L, Kline J, Dunai C, Aguilar E, Khuat L, Murphy W, Guerriero J, Sotayo A, Ponichtera H, Pourzia A, Schad S, Carrasco R, Lazo S, Bronson R, Letai A, Kornbluth R, Gupta S, Termini J, Guirado E, Stone G, Meyer C, Helming L, Tumang J, Wilson N, Hofmeister R, Radvanyi L, Neubert N, Tillé L, Barras D, Soneson C, Baumgaertner P, Rimoldi D, Gfeller D, Delorenzi M, Fuertes Marraco S, Speiser D, Abraham T, Xiang B, Magee M, Waldman S, Snook A, Blogowski W, Zuba-Surma E, Budkowska M, Salata D, Dolegowska B, Starzynska T, Chan L, Somanchi S, McCulley K, Lee D, Buettner N, Shi F, Myers P, Curbishley S, Penny S, Steadman L, Millar D, Speers E, Ruth N, Wong G, Thimme R, Adams D, Cobbold M, Thomas R, Hendrickx W, Al-Muftah M, Decock J, Wong M, Morse M, McDermott D, Clark J, Kaufman H, Daniels G, Hua H, Rao T, Dutcher J, Kang K, Saunthararajah Y, Velcheti V, Kumar V, Anwar F, Verma A, Chheda Z, Kohanbash G, Sidney J, Okada K, Shrivastav S, Carrera D, Liu S, Jahan N, Mueller S, Pollack I, Carcaboso A, Sette A, Hou Y, Okada H, Field J, Zeng W, Shih V, Law C, Senter P, Gardai S, Okeley N, Penny S, Abelin J, Saeed A, Malaker S, Myers P, Shabanowitz J, Ward S, Hunt D, Cobbold M, Profusek P, Wood L, Shepard D, Grivas P, Kapp K, Volz B, Oswald D, Wittig B, Schmidt M, Sefrin J, Hillringhaus L, Lifke V, Lifke A, Skaletskaya A, Ponte J, Chittenden T, Setiady Y, Valsesia-Wittmann S, Sivado E, Thomas V, El Alaoui M, Papot S, Dumontet C, Dyson M, McCafferty J, El Alaoui S, Verma A, Kumar V, Bommareddy P, Kaufman H, Zloza A, Kohlhapp F, Silk A, Jhawar S, Paneque T, Bommareddy P, Kohlhapp F, Newman J, Beltran P, Zloza A, Kaufman H, Cao F, Hong B, Rodriguez-Cruz T, Song X, Gottschalk S, Calderon H, Illingworth S, Brown A, Fisher K, Seymour L, Champion B, Eriksson E, Wenthe J, Hellström A, Paul-Wetterberg G, Loskog A, Eriksson E, Milenova I, Wenthe J, Ståhle M, Jarblad-Leja J, Ullenhag G, Dimberg A, Moreno R, Alemany R, Loskog A, Eriksson E, Milenova I, Moreno R, Alemany R, Loskog A, Jhawar S, Goyal S, Bommareddy P, Paneque T, Kaufman H, Zloza A, Kaufman H, Silk A, Mehnert J, Gabrail N, Bryan J, Medina D, Bommareddy P, Shafren D, Grose M, Zloza A, Mitchell L, Yagiz K, Lopez F, Mendoza D, Munday A, Gruber H, Jolly D, Fuhrmann S, Radoja S, Tan W, Pourchet A, Frey A, Mohr I, Mulvey M, Ranki T, Pesonen S, Capasso C, Ylösmäki E, Cerullo V, Andtbacka R, Ross M, Agarwala S, Grossmann K, Taylor M, Vetto J, Neves R, Daud A, Khong H, Meek S, Ungerleider R, Welden S, Tanaka M, Williams M, Andtbacka R, Curti B, Hallmeyer S, Fox B, Feng Z, Paustian C, Bifulco C, Grose M, Shafren D, Zafar S, Parviainen S, Siurala M, Hemminki O, Havunen R, Tähtinen S, Bramante S, Vassilev L, Wang H, Lieber A, Hemmi S, de Gruijl T, Kanerva A, Hemminki A, Ansari T, Sundararaman S, Roen D, Lehmann P, Bloom A, Bender L, Walters I, Terabe M, Berzofsky J, Chapelin F, Okada H, Ahrens E, DeFalco J, Harbell M, Manning-Bog A, Scholz A, Zhang D, Baia G, Tan Y, Sokolove J, Kim D, Williamson K, Chen X, Colrain J, Santo G, Nguyen N, Volkmuth W, Greenberg N, Robinson W, Emerling D, Drake C, Petrylak D, Antonarakis E, Kibel A, Chang N, Vu T, Campogan D, Haynes H, Trager J, Sheikh N, Quinn D, Kirk P, Addepalli M, Chang T, Zhang P, Konakova M, Hagihara K, Pai S, VanderVeen L, Obalapur P, Kuo P, Quach P, Fong L, Charych D, Zalevsky J, Langowski J, Addepalli M, Kirksey Y, Nutakki R, Kolarkar S, Pena R, Hoch U, Zalevsky J, Doberstein S, Charych D, Cha J, Mallon Z, Perez M, McDaniel A, Anand S, Uecker D, Nuccitelli R, McDaniel A, Anand S, Cha J, Uecker D, Nuccitelli R, Obermajer N, Urban J, Wieckowski E, Muthuswamy R, Ravindranathan R, Bartlett D, Kalinski P, Renrick A, Thounaojam M, Thomas P, Pellom S, Shanker A, Pellom S, Thounaojam M, Dudimah D, Brooks A, Sayers T, Shanker A, Su Y, Adamus T, Zhang Q, Nechaev S, Kortylewski M, Wei S, Allison J, Anderson C, Tang C, Schoenhals J, Tsouko E, Heymach J, de Groot P, Chang J, Hess K, Diab A, Sharma P, Allison J, Naing A, Hong D, Welsh J, Albershardt T, Parsons A, Leleux J, Reeves R, ter Meulen J, Berglund P, Ascarateil S, Koziol M, Penny S, Malaker S, Steadman L, Myers P, Bai D, Shabanowitz J, Hunt D, Cobbold M, Dai P, Wang W, Yang N, Shuman S, Merghoub T, Wolchok J, Deng L, Dillon P, Petroni G, Brenin D, Bullock K, Olson W, Smolkin M, Smith K, Nail C, Slingluff C, Sharma M, Fa’ak F, Janssen L, Khong H, Xiao Z, Hailemichael Y, Singh M, Vianden C, Diab A, Zalevsky J, Hoch U, Overwijk W, Facciabene A, Stefano P, Chongyung F, Rafail S, Hailemichael Y, Nielsen M, Fa’ak F, Vanderslice P, Woodside D, Market R, Biediger R, Marathi U, Overwijk W, Hollevoet K, Geukens N, Declerck P, Joly N, McIntosh L, Paramithiotis E, Rizell M, Sternby M, Andersson B, Karlsson-Parra A, Kuai R, Ochyl L, Schwendeman A, Moon J, Deng W, Hudson T, Lemmens E, Hanson B, Rae C, Burrill J, Skoble J, Katibah G, Murphy A, deVries M, Brockstedt D, Leong M, Lauer P, Dubensky T, Whiting C, Chen X, Hu Y, Xia Y, Zhou L, Bao Y, Huang S, Ren X, Hurt E, Hollingsworth R, Chang A, Wicha M, Li Q, Aggarwal C, Mangrolia D, Cohen R, Weinstein G, Morrow M, Bauml J, Kraynyak K, Boyer J, Yan J, Lee J, Humeau L, Oyola S, Duff S, Weiner D, Yang Z, Bagarazzi M, McNeel D, Eickhoff J, Jeraj R, Staab M, Straus J, Rekoske B, Liu G, Melssen M, Petroni G, Grosh W, Varhegyi N, Bullock K, Smolkin M, Smith K, Galeassi N, Deacon D, Gaughan E, Slingluff C, Ghisoli M, Barve M, Mennel R, Wallraven G, Manning L, Senzer N, Nemunaitis J, Ogasawara M, Ota S, Peace K, Hale D, Vreeland T, Jackson D, Berry J, Trappey A, Herbert G, Clifton G, Hardin M, Toms A, Qiao N, Litton J, Peoples G, Mittendorf E, Ghamsari L, Flano E, Jacques J, Liu B, Havel J, Makarov V, Merghoub T, Wolchok J, Hellmann M, Chan T, Flechtner J, Stefano P, Facciabene A, Facciponte J, Ugel S, De Sanctis F, Coukos G, Paris S, Pottier A, Levy L, Lu B, Cappuccini F, Pollock E, Bryant R, Hamdy F, Hill A, Redchenko I, Sultan H, Kumai T, Fesenkova V, Celis E, Tsang K, Fantini M, Fernando I, Palena C, David J, Hodge J, Gabitzsch E, Jones F, Gulley J, Schlom J, Herranz M, Rafail S, Ugel S, Facciponte J, Stefano P, Facciabene A, Wada H, Shimizu A, Osada T, Fukaya S, Sasaki E, Abolhalaj M, Askmyr D, Lundberg K, Albrekt A, Greiff L, Lindstedt M, Flies D, Higuchi T, Ornatowski W, Harris J, Adams S, Aguilera T, Rafat M, Castellini L, Shehade H, Kariolis M, Jang D, vonEbyen R, Graves E, Ellies L, Rankin E, Koong A, Giaccia A, Ajina R, Wang S, Smith J, Pierobon M, Jablonski S, Petricoin E, Weiner L, Sherry L, Waller J, Anderson M, Bigley A, Bernatchez C, Haymaker C, Tannir N, Kluger H, Tetzlaff M, Jackson N, Gergel I, Tagliaferri M, Zalevsky J, Hoch U, Hwu P, Snzol M, Hurwitz M, Diab A, Barberi T, Martin A, Suresh R, Barakat D, Harris-Bookman S, Drake C, Friedman A, Berkey S, Downs-Canner S, Delgoffe G, Edwards R, Curiel T, Odunsi K, Bartlett D, Obermajer N, Bruno T, Moore B, Squalls O, Ebner P, Waugh K, Mitchell J, Franklin W, Merrick D, McCarter M, Palmer B, Kern J, Vignali D, Slansky J, Chan A, Qiu X, Fraser K, Jonas A, Ottoson N, Gordon K, Kangas T, Leonardo S, Ertelt K, Walsh R, Uhlik M, Graff J, Bose N, Gupta R, Mandloi N, Paul K, Patil A, Sathian R, Mohan A, Manoharan M, Chaudhuri A, Chen Y, Lin J, Ye Y, Xu C, Chen G, Guo Z, Komarov A, Chenchik A, Makhanov M, Frangou C, Zheng Y, Coltharp C, Unfricht D, Dilworth R, Fridman L, Liu L, Rajopadhye M, Miller P, Concha-Benavente F, Bauman J, Trivedi S, Srivastava R, Ohr J, Heron D, Duvvuri U, Kim S, Gooding W, Ferris R, Torrey H, Mera T, Okubo Y, Vanamee E, Foster R, Faustman D, Gartrell R, Stack E, Lu Y, Izaki D, Beck K, Jia D, Armenta P, White-Stern A, Fu Y, Blake Z, Marks D, Kaufman H, Taback B, Horst B, Saenger Y, Glickman L, Kanne D, Gauthier K, Desbien A, Francica B, Katibah G, Corrales L, Leong J, Sung L, Metchette K, Kasibhatla S, Pferdekamper A, Zheng L, Cho C, Feng Y, McKenna J, Tallarico J, Bender S, Ndubaku C, McWhirter S, Drake C, Gajewski T, Dubensky T, Gugel E, Bell C, Munk A, Muniz L, Bhardwaj N, Zhao F, Evans K, Xiao C, Holtzhausen A, Hanks B, Scholler N, Yin C, Van der Meijs P, Prantner A, Krejsa C, Smith L, Johnson B, Branstetter D, Stein P, Jaen J, Tan J, Chen A, Chen Y, Park T, Powers J, Sexton H, Xu G, Young S, Schindler U, Deng W, Klinke D, Komar H, Mace T, Serpa G, Elnaggar O, Conwell D, Hart P, Schmidt C, Dillhoff M, Jin M, Ostrowski M, Lesinski G, Koti M, Au K, Peterson N, Truesdell P, Reid-Schachter G, Graham C, Craig A, Francis J, Kotlan B, Balatoni T, Farkas E, Toth L, Ujhelyi M, Savolt A, Doleschall Z, Horvath S, Eles K, Olasz J, Csuka O, Kasler M, Liszkay G, Barnea E, Kumar S, Tsujikawa T, Blakely C, Flynn P, Goodman R, Bueno R, Sugarbaker D, Jablons D, Broaddus V, West B, Coussens L, Kunk P, Obeid J, Winters K, Pramoonjago P, Smolkin M, Stelow E, Bauer T, Slingluff C, Rahma O, Lamble A, Kosaka Y, Huang F, Saser K, Adams H, Tognon C, Laderas T, McWeeney S, Loriaux M, Tyner J, Druker B, Lind E, Liu Z, Lu S, Kane L, Ferris R, Liu Z, Shayan G, Lu S, Ferris R, Femel J, Tsujikawa T, Lane R, Booth J, Lund A, Melssen M, Rodriguez A, Slingluff C, Engelhard V, Metelli A, Wu B, Fugle C, Saleh R, Sun S, Wu J, Liu B, Li Z, Morris Z, Guy E, Heinze C, Kler J, Gressett M, Werner L, Gillies S, Korman A, Loibner H, Hank J, Rakhmilevich A, Harari P, Sondel P, Newman J, Zloza A, Huelsmann E, Broucek J, Kaufman H, Brech D, Straub T, Irmler M, Beckers J, Buettner F, Schaeffeler E, Schwab M, Noessner E, Anand S, McDaniel A, Cha J, Uecker D, Nuccitelli R, Ordentlich P, Wolfreys A, Da Costa A, Silva J, Crosby A, Staelens L, Craggs G, Cauvin A, Mason S, Paterson A, Lake A, Armet C, O’Connor R, Hill J, Normant E, Adam A, Biniszkiewicz D, Chappel S, Palombella V, Holland P, Powers J, Becker A, Chen A, Leleti M, Newcomb E, Sexton H, Schindler U, Tan J, Young S, Jaen J, Rapisuwon S, Radfar A, Gardner K, Gibney G, Atkins M, Rennier K, Crowder R, Wang P, Pachynski R, Carrero R, Rivas S, Beceren-Braun F, Anthony S, Schluns K, Sawant D, Chikina M, Yano H, Workman C, Vignali D, Salerno E, Bedognetti D, Mauldin I, Deacon D, Shea S, Pinczewski J, Obeid J, Coukos G, Wang E, Gajewski T, Marincola F, Slingluff C, Spranger S, Horton B, Gajewski T, Suzuki A, Leland P, Joshi B, Puri R, Sweis R, Bao R, Luke J, Gajewski T, Theodoraki M, Mogundo F, Edwards R, Kalinski P, Won H, Moreira D, Gao C, Zhao X, Duttagupta P, Jones J, D’Apuzzo M, Pal S, Kortylewski M. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two. Journal For ImmunoTherapy Of Cancer 2016, 4: 73. PMCID: PMC5123381, DOI: 10.1186/s40425-016-0173-6.
- Sharma P, Callahan MK, Bono P, Kim J, Spiliopoulou P, Calvo E, Pillai RN, Ott PA, de Braud F, Morse M, Le DT, Jaeger D, Chan E, Harbison C, Lin CS, Tschaika M, Azrilevich A, Rosenberg JE. Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial. The Lancet Oncology 2016, 17: 1590-1598. PMID: 27733243, PMCID: PMC5648054, DOI: 10.1016/s1470-2045(16)30496-x.
- Farsaci B, Donahue R, Grenga I, Lepone L, Kim P, Dempsey B, Siebert J, Ibrahim N, Madan R, Heery C, Gulley J, Schlom J. Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy. Cancer Immunology Research 2016, 4: 755-765. PMID: 27485137, PMCID: PMC5138028, DOI: 10.1158/2326-6066.cir-16-0037.
- Heery C, Madan R, Stein M, Stadler W, Di Paola R, Rauckhorst M, Steinberg S, Marté J, Chen C, Grenga I, Donahue R, Jochems C, Dahut W, Schlom J, Gulley J. Samarium-153-EDTMP (Quadramet ® ) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial. Oncotarget 2016, 7: 69014-69023. PMID: 27486817, PMCID: PMC5340090, DOI: 10.18632/oncotarget.10883.
- Grenga I, Donahue R, Lepone L, Richards J, Schlom J. A fully human IgG1 anti‐PD‐L1 MAb in an in vitro assay enhances antigen‐specific T‐cell responses. Clinical & Translational Immunology 2016, 5: e83. PMID: 27350882, PMCID: PMC4910121, DOI: 10.1038/cti.2016.27.
- Roselli M, Formica V, Cereda V, Jochems C, Richards J, Grenga I, Orlandi A, Ferroni P, Guadagni F, Schlom J. The association of clinical outcome and peripheral T-cell subsets in metastatic colorectal cancer patients receiving first-line FOLFIRI plus bevacizumab therapy. OncoImmunology 2016, 5: e1188243. PMID: 27622042, PMCID: PMC5006891, DOI: 10.1080/2162402x.2016.1188243.
- Jochems C, Fantini M, Fernando R, Kwilas A, Donahue R, Lepone L, Grenga I, Kim Y, Brechbiel M, Gulley J, Madan R, Heery C, Hodge J, Newton R, Schlom J, Tsang K. The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells. Oncotarget 2016, 7: 37762-37772. PMID: 27192116, PMCID: PMC5122347, DOI: 10.18632/oncotarget.9326.
- Lepone L, Donahue R, Grenga I, Metenou S, Richards J, Heery C, Madan R, Gulley J, Schlom J. Analyses of 123 Peripheral Human Immune Cell Subsets: Defining Differences with Age and between Healthy Donors and Cancer Patients Not Detected in Analysis of Standard Immune Cell Types. Journal Of Circulating Biomarkers 2016, 5 DOI: 10.33393/jcb.2016.2071.
- Apolo AB, Lindenberg L, Shih JH, Mena E, Kim JW, Park JC, Alikhani A, McKinney YY, Weaver J, Turkbey B, Parnes HL, Wood LV, Madan RA, Gulley JL, Dahut WL, Kurdziel KA, Choyke PL. Prospective Study Evaluating Na18F PET/CT in Predicting Clinical Outcomes and Survival in Advanced Prostate Cancer. Journal Of Nuclear Medicine 2016, 57: 886-892. PMID: 26795292, PMCID: PMC6599519, DOI: 10.2967/jnumed.115.166512.
- Lepone L, Donahue R, Grenga I, Metenou S, Richards J, Heery C, Madan R, Gulley J, Schlom J. Analyses of 123 Peripheral Human Immune Cell Subsets: Defining Differences with Age and between Healthy Donors and Cancer Patients Not Detected in Analysis of Standard Immune Cell Types. Journal Of Circulating Biomarkers 2016, 5: 5. PMID: 28936253, PMCID: PMC5548330, DOI: 10.5772/62322.
- Grenga I, Kwilas A, Donahue R, Farsaci B, Hodge J. Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack. Journal For ImmunoTherapy Of Cancer 2015, 3: 52. PMID: 26579226, PMCID: PMC4647578, DOI: 10.1186/s40425-015-0096-7.
- Heery C, Ibrahim N, Arlen P, Mohebtash M, Murray J, Koenig K, Madan R, McMahon S, Marté J, Steinberg S, Donahue R, Grenga I, Jochems C, Farsaci B, Folio L, Schlom J, Gulley J. Docetaxel Alone or in Combination With a Therapeutic Cancer Vaccine (PANVAC) in Patients With Metastatic Breast Cancer: A Randomized Clinical Trial. JAMA Oncology 2015, 1: 1087. PMID: 26291768, PMCID: PMC6622177, DOI: 10.1001/jamaoncol.2015.2736.
- Heery C, Singh B, Rauckhorst M, Marté J, Donahue R, Grenga I, Rodell T, Dahut W, Arlen P, Madan R, Schlom J, Gulley J. Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury. Cancer Immunology Research 2015, 3: 1248-1256. PMID: 26130065, PMCID: PMC4636967, DOI: 10.1158/2326-6066.cir-15-0119.
- Kim JW, Tomita Y, Trepel J, Apolo AB. Emerging immunotherapies for bladder cancer. Current Opinion In Oncology 2015, 27: 191-200. PMID: 25811346, PMCID: PMC7709951, DOI: 10.1097/cco.0000000000000177.
- Kim JW, Eder JP. Prospects for targeting PD-1 and PD-L1 in various tumor types. Oncology 2014, 28 Suppl 3: 15-28. PMID: 25387682.
- Kim JW, Bilusic M, Plimack ER. Mechanisms of immunotherapy resistance in mCRPC: identifying the enemy on the visceral metastatic battlefield. Oncology 2014, 28: 986-90. PMID: 25403631.
- Farsaci B, Donahue R, Coplin M, Grenga I, Lepone L, Molinolo A, Hodge J. Immune Consequences of Decreasing Tumor Vasculature with Antiangiogenic Tyrosine Kinase Inhibitors in Combination with Therapeutic Vaccines. Cancer Immunology Research 2014, 2: 1090-1102. PMID: 25092771, PMCID: PMC4221465, DOI: 10.1158/2326-6066.cir-14-0076.
- Apolo AB, Kim JW, Bochner BH, Steinberg SM, Bajorin DF, Kelly K, Agarwal PK, Koppie TM, Kaag MG, Quinn DI, Vogelzang NJ, Sridhar SS. Examining the management of muscle-invasive bladder cancer by medical oncologists in the United States11Funding source: The US Office of Management and Budget (0925-0046). Urologic Oncology Seminars And Original Investigations 2014, 32: 637-644. PMID: 24840869, PMCID: PMC6771274, DOI: 10.1016/j.urolonc.2013.12.012.
- Kim P, Jochems C, Grenga I, Donahue R, Tsang K, Gulley J, Schlom J, Farsaci B. Pan-Bcl-2 Inhibitor, GX15-070 (Obatoclax), Decreases Human T Regulatory Lymphocytes while Preserving Effector T Lymphocytes: A Rationale for Its Use in Combination Immunotherapy. The Journal Of Immunology 2014, 192: 2622-2633. PMID: 24516200, PMCID: PMC4122292, DOI: 10.4049/jimmunol.1301369.
- Farsaci B, Jochems C, Grenga I, Donahue R, Tucker J, Pinto P, Merino M, Heery C, Madan R, Gulley J, Schlom J. Identification by digital immunohistochemistry of intratumoral changes of immune infiltrates after vaccine in the absence of modifications of PBMC immune cell subsets. International Journal Of Cancer 2014, 135: 862-870. PMID: 24474335, PMCID: PMC6467468, DOI: 10.1002/ijc.28743.
- Kim JW, Bilusic M, Heery CJ, Madan RA. Therapeutic Cancer Vaccines in Prostate Cancer: The Quest for Intermediate Markers of Response. Cancers 2012, 4: 1229-1246. PMID: 24213505, PMCID: PMC3712729, DOI: 10.3390/cancers4041229.
- Kim JW, Marshall JL. Improving harmonious precision. Oncology 2012, 26: 949, 954. PMID: 23176007.
- Kim JW. ASCO beyond McCormick: perseverance, collaboration, mentorship. Community Oncology 2012, 9: 265. PMID: 23028260, PMCID: PMC3460519, DOI: 10.1016/j.cmonc.2012.07.004.
- Kim JW, Gulley JL. Poxviral vectors for cancer immunotherapy. Expert Opinion On Biological Therapy 2012, 12: 463-478. PMID: 22413824, PMCID: PMC3482162, DOI: 10.1517/14712598.2012.668516.
- Ferroni P, Martini F, Portarena I, Grenga I, Riondino S, La Farina F, Laudisi A, Guadagni F, Roselli M. Early changes of a novel APC-dependent thrombin generation assay during chemotherapy independently predict venous thromboembolism in cancer patients—a pilot study. Supportive Care In Cancer 2012, 20: 2713-2720. PMID: 22322591, DOI: 10.1007/s00520-012-1391-1.
- Kim JW, Madan RA, Gulley JL. Initial PSA Oscillations Precede Prolonged Stable Disease in a Patient Treated With a Therapeutic Cancer Vaccine. Clinical Genitourinary Cancer 2011, 10: 43-46. PMID: 22019260, PMCID: PMC3279569, DOI: 10.1016/j.clgc.2011.09.003.
- Martini F, Portarena I, Grenga I, Riondino S, Farina F, Laudisi A, Roselli M, Guadagni F, Ferroni P. An activated protein C-dependent thrombin generation assay predicts chemotherapy-associated venous thromboembolism in cancer patients. Thrombosis And Haemostasis 2011, 105: 931-932. PMID: 21359410, DOI: 10.1160/th10-11-0757.
- Formica V, Del Monte G, Giacchetti I, Grenga I, Giaquinto S, Fini M, Roselli M. Rehabilitation in Neuro-Oncology: A Meta-Analysis of Published Data and a Mono-Institutional Experience. Integrative Cancer Therapies 2010, 10: 119-126. PMID: 21196433, DOI: 10.1177/1534735410392575.
- Formica V, Palmirotta R, Del Monte G, Savonarola A, Ludovici G, De Marchis M, Grenga I, Schirru M, Guadagni F, Roselli M. Predictive value of VEGF gene polymorphisms for metastatic colorectal cancer patients receiving first-line treatment including fluorouracil, irinotecan, and bevacizumab. International Journal Of Colorectal Disease 2010, 26: 143-151. PMID: 21188390, DOI: 10.1007/s00384-010-1108-1.
- Pellegrino R, Formica V, Portarena I, Mariotti S, Grenga I, Del Monte G, Roselli M. Caregiver distress in the early phases of cancer. Anticancer Research 2010, 30: 4657-63. PMID: 21115920.
- Kim JW, Amin AR, Shin DM. Chemoprevention of Head and Neck Cancer with Green Tea Polyphenols. Cancer Prevention Research 2010, 3: 900-909. PMID: 20663981, PMCID: PMC2917478, DOI: 10.1158/1940-6207.capr-09-0131.
- Formica V, Massara M, Portarena I, Fiaschetti V, Grenga I, Del Vecchio Blanco G, Sileri P, Tosetto L, Skoulidis F, Pallone F, Roselli M. Role of CA19.9 in predicting bevacizumab efficacy for metastatic colorectal cancer patients. Cancer Biomarkers 2009, 5: 167-175. PMID: 19729826, PMCID: PMC12922835, DOI: 10.3233/cbm-2009-0101.
- Hicks AM, Riedlinger G, Willingham MC, Alexander-Miller MA, Von Kap-Herr C, Pettenati MJ, Sanders AM, Weir HM, Du W, Kim J, Simpson AJ, Old LJ, Cui Z. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 7753-7758. PMID: 16682640, PMCID: PMC1458507, DOI: 10.1073/pnas.0602382103.
- Limentani SA, Asher A, Heafner M, Kim JW, Fraser R. A phase I trial of surgery, Gliadel wafer implantation, and immediate postoperative carboplatin in combination with radiation therapy for primary anaplastic astrocytoma or glioblastoma multiforme. Journal Of Neuro-Oncology 2005, 72: 241-244. PMID: 15937647, DOI: 10.1007/s11060-004-2339-1.
- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Smilow Cancer Hospital Prostate and Urologic Cancers ProgramSmilow Cancer Hospital at North Haven6 Devine Street, Fl 2North Haven, CT 06473
- Smilow Cancer HospitalSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
- Smilow Cancer Hospital Prostate and Urologic Cancers ProgramSmilow Cancer Hospital at North Haven6 Devine Street, Fl 2North Haven, CT 06473