- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473
Wonnie Ryu, MD, MPH
Telehealth is available
Patient type treated
Adult
Accepting new patients
Yes
Referral required
Not Applicable
Board Certified in
Internal Medicine, Pulmonary Disease
, and Critical Care Medicine (Internal Medicine)
Titles
- Assistant Professor
Education & Training
- MDNew York Medical College (2008)
- MPHDartmouth College (2004)
- BSEmory University (2003)
Additional Information
Honors & Recognitions
- 1K08HL151970-01: NIH/NHLBI (2020)
- John R. Addrizzo, MD, FCCP Research Grant in Sarcoidosis Award: Chest Foundation (2020)
- Boehringer Ingelheim IPF/ILD Discovery Award: Boehringer Ingelheim (2019)
- Recognition of Early Academic Achievement Award: American Thoracic Society (2018)
- Parker B. Francis Foundation Award: Parker B. Francis Foundation (2018)
- Foundation for Sarcoidosis Research Award: Foundation of Sarcoidosis Research (2017)
- Respiratory Disease Young Investigators' Award: National Jewish Health (2016)
Professional Service
- Graduate Medical Education Committee (2015 - 2016): Member
Publications
- Fiorini V, Hu B, Sun Y, Yu S, McGovern J, Gandhi S, Woo S, Turcotte-Foster S, Pivarnik T, Khan Z, Adams T, Herzog E, Kaminski N, Gulati M, Ryu C. Circulating Mitochondrial DNA is associated with High Levels of Fatigue in Two Independent Sarcoidosis Cohorts. CHEST Journal 2023 PMID: 37977267, DOI: 10.1016/j.chest.2023.11.020.
- Woo S, Gandhi S, Ghincea A, Saber T, Lee C, Ryu C. Targeting the NLRP3 inflammasome and associated cytokines in scleroderma associated interstitial lung disease. Frontiers In Cell And Developmental Biology 2023, 11: 1254904. PMID: 37849737, PMCID: PMC10577231, DOI: 10.3389/fcell.2023.1254904.
- Schupp J, Manning E, Chioccioli M, Kamp J, Christian L, Ryu C, Herzog E, Kühnel M, Prasse A, Kaminski N, Jonigk D, Homer R, Neubert L, Ius F, stringJustet A, Hariri L, Seeliger B, Welte T, Knipe R, Gottlieb J. Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 819-822. PMID: 37552025, PMCID: PMC10563189, DOI: 10.1164/rccm.202303-0544le.
- Çakan E, Kioon M, Garcia-Carmona Y, Glauzy S, Oliver D, Yamakawa N, Loza A, Du Y, Schickel J, Boeckers J, Yang C, Baldo A, Ivashkiv L, Young R, Staudt L, Moody K, Nündel K, Marshak-Rothstein A, van der Made C, Hoischen A, Hayward A, Rossato M, Radstake T, Cunningham-Rundles C, Ryu C, Herzog E, Barrat F, Meffre E. TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance. Journal Of Experimental Medicine 2023, 220: e20230944. PMID: 37773045, PMCID: PMC10541333, DOI: 10.1084/jem.20230944.
- Ghincea A, Woo S, Yu S, Pivarnik T, Fiorini V, Herzog E, Ryu C. Mitochondrial DNA-Sensing Pathogen Recognition Receptors in Systemic Sclerosis-Associated Interstitial Lung Disease: a Review. Current Treatment Options In Rheumatology 2023, 9: 204-220. PMID: 38230363, PMCID: PMC10791121, DOI: 10.1007/s40674-023-00211-1.
- Yu S, Woo S, Hu B, Sun Y, Fiorini V, Van Horn C, Gunes B, Hinchcliff M, Varga J, Herzog E, Ryu C. Elevated Levels of Mitochondrial DNA and CGAS Ligands Are Found in Scleroderma Associated Interstitial Lung Disease and Mediate Fibroblast Activation. 2023, a2279-a2279. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2279.
- Fiorini V, Hu B, Sun Y, Yu S, McGovern J, Woo S, Khan Z, Adams T, Pivarnik T, Herzog E, Ryu C. Plasma Mitochondrial DNA Is Associated With Patient-related Outcome Measures in Sarcoidosis. 2023, a2275-a2275. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2275.
- Ryu C, Sand J, Juhl P, Jessen H, Leeming D, Hu B, Sun Y, Adams T, Pivarnik T, Yu S, Woo S, McGovern J, Fiorini V, Goobie G, Zhang Y, Herzog E. Serum Collagen Neoepitopes Are Associated With Multi-organ Disease in the Access and GRADS Sarcoidosis Cohorts. 2023, a2242-a2242. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2242.
- Ryu C, Hu B, Sun Y, Yu S, Woo S, Fiorini V, Pivarnik T, Mcgovern J, Peng X, Herzog E, Trujillo G. Mitochondrial DNA-toll-like Receptor 9 Interactions Drives Fibrosis in the Adult Lung. 2023, a1376-a1376. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1376.
- Lee C, He C, Park J, Lee J, Kamle S, Ma B, Akosman B, Cotez R, Chen E, Zhou Y, Herzog E, Ryu C, Peng X, Rosas I, Poli S, Bostwick C, Choi A, Elias J, Lee C. Correction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Science Alliance 2023, 6: e202302065. PMID: 37037591, PMCID: PMC10088146, DOI: 10.26508/lsa.202302065.
- Ahangari F, Price N, Malik S, Chioccioli M, Bärnthaler T, Adams T, Kim J, Pradeep S, Ding S, Cosme C, Rose K, McDonough J, Aurelien N, Ibarra G, Omote N, Schupp J, DeIuliis G, Nunez J, Sharma L, Ryu C, Dela Cruz C, Liu X, Prasse A, Rosas I, Bahal R, Fernandez-Hernando C, Kaminski N. microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight 2023, 8: e158100. PMID: 36626225, PMCID: PMC9977502, DOI: 10.1172/jci.insight.158100.
- Ishikawa G, Peng X, McGovern J, Woo S, Perry C, Liu A, Yu S, Ghincea A, Kishchanka A, Fiorini V, Hu B, Sun Y, Sun H, Ryu C, Herzog E. α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2023, 324: l639-l651. PMID: 36648147, PMCID: PMC10110730, DOI: 10.1152/ajplung.00119.2022.
- FIORINI V, MCGOVERN J, HU B, SUN Y, KHAN Z, HERZOG E, RYU C. PATIENT-RELATED OUTCOMES AND BIOLOGIC MEDIATORS OF SARCOIDOSIS. CHEST Journal 2022, 162: a2692. DOI: 10.1016/j.chest.2022.08.2191.
- Ryan SM, Mroz MM, Herzog EL, Ryu C, Fingerlin TE, Maier LA, Gulati M. Occupational and environmental exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study. Respiratory Medicine 2022, 200: 106923. PMID: 35932543, DOI: 10.1016/j.rmed.2022.106923.
- Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis. Nature Communications 2022, 13: 3140. PMID: 35668129, PMCID: PMC9170782, DOI: 10.1038/s41467-022-30615-x.
- Liu A, Sharma L, Yan X, Dela Cruz CS, Herzog EL, Ryu C. Emerging insights in sarcoidosis: moving forward through reverse translational research. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2022, 322: l518-l525. PMID: 35196896, PMCID: PMC8957321, DOI: 10.1152/ajplung.00266.2021.
- Ghincea A, Ryu C, Herzog EL. An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination A Case Report. CHEST Journal 2022, 161: e71-e73. PMID: 35131075, PMCID: PMC8814523, DOI: 10.1016/j.chest.2021.07.2160.
- Glauzy S, Olson B, May CK, Parisi D, Massad C, Hansen JE, Ryu C, Herzog EL, Meffre E. Defective Early B Cell Tolerance Checkpoints in Patients With Systemic Sclerosis Allow the Production of Self Antigen–Specific Clones. Arthritis & Rheumatology 2021, 74: 307-317. PMID: 34279059, PMCID: PMC8766600, DOI: 10.1002/art.41927.
- Pednekar P, Amoah K, Homer R, Ryu C, Lutchmansingh DD. Case Report: Bullous Lung Disease Following COVID-19. Frontiers In Medicine 2021, 8: 770778. PMID: 34869488, PMCID: PMC8635639, DOI: 10.3389/fmed.2021.770778.
- Pednekar P, Amoah K, homer R, Ryu C, Lutchmansingh D. BULLOUS LUNG DISEASE FOLLOWING COVID-19 INFECTION. CHEST Journal 2021, 160: a356. PMCID: PMC8503349, DOI: 10.1016/j.chest.2021.07.358.
- Zhao A, Unterman A, Schupp J, Adams T, Sumida T, Ryu C, DeIuliis G, Yan X, Hafler D, Dela Cruz C, Herzog E, Kaminski N. Comparative scRNA-seq Analysis of Peripheral Blood Mononuclear Cells from Patients with COVID-19 and Idiopathic Pulmonary Fibrosis Demonstrates Dissimilar Cell Shifts and Gene Expression Profiles. 2021, a4361-a4361. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4361.
- Minasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog E, Dela Cruz C, Ryu C. IL-15 Is Independent of Pulmonary Sarcoid Granuloma Formation In Vivo. 2021, a4263-a4263. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4263.
- Minasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Liu A, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog EL, Dela Cruz CS, Ryu C. Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2021, 320: l1137-l1146. PMID: 33851886, PMCID: PMC8285626, DOI: 10.1152/ajplung.00575.2020.
- Ryu C, Walia A, Ortiz V, Perry C, Woo S, Reeves BC, Sun H, Winkler J, Kanyo JE, Wang W, Vukmirovic M, Ristic N, Stratton EA, Meena SR, Minasyan M, Kurbanov D, Liu X, Lam TT, Farina G, Gomez JL, Gulati M, Herzog EL. Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma‐Associated Interstitial Lung Disease. Arthritis & Rheumatology 2020, 72: 1905-1915. PMID: 32602227, PMCID: PMC8081728, DOI: 10.1002/art.41418.
- Sakamoto K, Furukawa T, Yamano Y, Kataoka K, Teramachi R, Walia A, Suzuki A, Inoue M, Nakahara Y, Ryu C, Hashimoto N, Kondoh Y. Serum mitochondrial DNA predicts the risk of acute exacerbation and progression of idiopathic pulmonary fibrosis. European Respiratory Journal 2020, 57: 2001346. PMID: 32855220, PMCID: PMC8177039, DOI: 10.1183/13993003.01346-2020.
- Walia A, Singh I, Ryu C, Lutchmansingh DD. A 50-Year-Old Woman With Limited Scleroderma Presenting With Shortness of Breath. CHEST Journal 2020, 158: e37-e40. PMID: 32654737, PMCID: PMC8097629, DOI: 10.1016/j.chest.2020.02.041.
- Chen W, Karhadkar TR, Ryu C, Herzog EL, Gomer RH. Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis. ImmunoHorizons 2020, 4: 352-362. PMID: 32576593, PMCID: PMC8500545, DOI: 10.4049/immunohorizons.2000043.
- Khan Z, Carrano D, Minasyan M, Gulati M, Ryu C, Herzog E. Rationale, Design, and Results of the Idiopathic Pulmonary Fibrosis "Sadokine" Pilot Study. 2020, a6580-a6580. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6580.
- Minasyan M, Herzog E, Dela Cruz C, Ryu C. IL-15 Is Elevated in the Bronchoalveolar Lavage of Patients with Pulmonary Sarcoidosis. 2020, a3108-a3108. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3108.
- Unterman A, Neumark N, Zhao A, Schupp J, Ryu C, Antin-Ozerkis D, Winkler J, Herazo-Maya J, Herzog E, Kaminski N. Single Cell RNA Sequencing of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis Reveals the Cellular Origin of the Outcome Predictive 52-Gene Signature. 2020, a6211-a6211. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6211.
- Perry C, Gao R, Peng X, Ntokou A, Ryu C, Gomez J, Reeves B, Walia A, Sun H, Black K, Hariri L, Moore M, Gulati M, Homer R, Greif D, Eltzschig H, Herzog E. Adrenergic Nerve-Associated Lung Fibrosis Is Driven by Myeloid Netrin-1. 2020, a2410-a2410. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2410.
- Zhang Y, Jiang M, Nouraie M, Roth MG, Tabib T, Winters S, Chen X, Sembrat J, Chu Y, Cardenes N, Tuder RM, Herzog EL, Ryu C, Rojas M, Lafyatis R, Gibson KF, McDyer JF, Kass DJ, Alder JK. GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2019, 317: l510-l521. PMID: 31432710, PMCID: PMC6842909, DOI: 10.1152/ajplung.00062.2019.
- Ryu C, Brandsdorfer C, Adams T, Hu B, Kelleher DW, Yaggi M, Manning EP, Walia A, Reeves B, Pan H, Winkler J, Minasyan M, Dela Cruz CS, Kaminski N, Gulati M, Herzog EL. Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis. European Respiratory Journal 2019, 54: 1801762. PMID: 31273041, PMCID: PMC8088542, DOI: 10.1183/13993003.01762-2018.
- Manning EP, Losier A, Emeagwali N, Ryu C, Honiden S. New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 1561-1563. PMID: 30822095, PMCID: PMC7051474, DOI: 10.1164/rccm.201809-1700rr.
- Lee CM, He CH, Park JW, Lee JH, Kamle S, Ma B, Akosman B, Cotez R, Chen E, Zhou Y, Herzog EL, Ryu C, Peng X, Rosas IO, Poli S, Bostwick CF, Choi AM, Elias JA, Lee CG. Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Science Alliance 2019, 2: e201900350. PMID: 31085559, PMCID: PMC6516052, DOI: 10.26508/lsa.201900350.
- Ryu C, Sun H, Winkler J, Meena S, Walia A, Minasyan M, Brandsdorfer C, Gulati M, Peng X, Herzog E. Circulating Mitochondrial DNA Is Associated with Fibroblast Activation and Disease Progression in Scleroderma Associated Interstitial Lung Disease. 2019, a7219-a7219. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7219.
- Xie Y, Ostriker AC, Jin Y, Hu H, Sizer AJ, Peng G, Morris AH, Ryu C, Herzog EL, Kyriakides T, Zhao H, Dardik A, Yu J, Hwa J, Martin KA. LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis. Circulation 2019, 139: 679-693. PMID: 30586711, PMCID: PMC6371979, DOI: 10.1161/circulationaha.118.034615.
- Tzouvelekis A, Herazo‐Maya J, Ryu C, Chu J, Zhang Y, Gibson KF, Adonteng‐Boateng P, Li Q, Pan H, Cherry B, Ahmad F, Ford HJ, Herzog EL, Kaminski N, Fares WH. S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension. Respirology 2018, 23: 771-779. PMID: 29611244, PMCID: PMC6047907, DOI: 10.1111/resp.13302.
- Ryu C, Boffa D, Bramley K, Pisani M, Puchalski J. A novel endobronchial approach to massive hemoptysis complicating silicone Y-stent placement for tracheobronchomalacia. Medicine 2018, 97: e9980. PMID: 29465600, PMCID: PMC5842006, DOI: 10.1097/md.0000000000009980.
- Murray LA, Habiel DM, Hohmann M, Camelo A, Shang H, Zhou Y, Coelho AL, Peng X, Gulati M, Crestani B, Sleeman MA, Mustelin T, Moore MW, Ryu C, Osafo-Addo AD, Elias JA, Lee CG, Hu B, Herazo-Maya JD, Knight DA, Hogaboam CM, Herzog EL. Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis. JCI Insight 2017, 2: e92192. PMID: 28814671, PMCID: PMC5621899, DOI: 10.1172/jci.insight.92192.
- Ryu C, Sun H, Gulati M, Herazo-Maya J, Chen Y, Osafo-Addo A, Brandsdorfer C, Winkler J, Blaul C, Faunce J, Pan H, Woolard T, Tzouvelekis A, Antin-Ozerkis DE, Puchalski JT, Slade M, Gonzalez AL, Bogenhagen DF, Kirillov V, Feghali-Bostwick C, Gibson K, Lindell K, Herzog RI, Dela Cruz CS, Mehal W, Kaminski N, Herzog EL, Trujillo G. Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2017, 196: 1571-1581. PMID: 28783377, PMCID: PMC5754440, DOI: 10.1164/rccm.201612-2480oc.
- Ryu C, Herzog EL, Pan H, Homer R, Gulati M. Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report. American Journal Of Case Reports 2017, 18: 157-159. PMID: 28190872, PMCID: PMC5319306, DOI: 10.12659/ajcr.902231.
- Tzouvelekis A, Herazo‐Maya J, Slade M, Chu J, Deiuliis G, Ryu C, Li Q, Sakamoto K, Ibarra G, Pan H, Gulati M, Antin‐Ozerkis D, Herzog EL, Kaminski N. Validation of the prognostic value of MMP‐7 in idiopathic pulmonary fibrosis. Respirology 2016, 22: 486-493. PMID: 27761978, PMCID: PMC5352520, DOI: 10.1111/resp.12920.
- Peng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, Herazo‐Maya J, Kaminski N, Hu X, Pan H, Ryu C, Osafo‐Addo A, Homer RJ, Feghali‐Bostwick C, Fares W, Gulati M, Hu B, Lee C, Elias JA, Herzog EL. Plexin C1 deficiency permits synaptotagmin 7–mediated macrophage migration and enhances mammalian lung fibrosis. The FASEB Journal 2016, 30: 4056-4070. PMID: 27609773, PMCID: PMC5102121, DOI: 10.1096/fj.201600373r.
- Ryu C, Homer RJ, Herzog EL. The Airway in Idiopathic Pulmonary Fibrosis: Protecting the Lung or Promoting Disease? American Journal Of Respiratory And Critical Care Medicine 2016, 193: 1081-1082. PMID: 27174477, PMCID: PMC4872674, DOI: 10.1164/rccm.201601-0055ed.
- Ryu C, Puchalski J, Perkins M, Honiden S. Management of an elderly patient with respiratory failure due to double aortic arch. Respiratory Medicine Case Reports 2015, 17: 37-39. PMID: 27222782, PMCID: PMC4821450, DOI: 10.1016/j.rmcr.2015.12.002.
- Lutchmansingh D, Ryu C, Lenox R. 1260. Critical Care Medicine 2013, 41: a324. DOI: 10.1097/01.ccm.0000440492.30842.15.
- Dalal P, Singh S, Ulahanan J, Ryu C, Mitchell J, Humpheries D. A Quality Improvement Project to Reduce Congestive Heart Failure Mortality With Intensive Case Management. CHEST Journal 2013, 144: 404a-404b. DOI: 10.1378/chest.1704688.
- Ulahannan J, Singh S, Dalal P, Humphreys D, Mitchell J, Ryu C. A Collaborative Initiative to Utilize Telehealth Medicine for Veterans With Congestive Heart Failure to Reduce Hospital Readmissions. CHEST Journal 2013, 144: 535a-535b. DOI: 10.1378/chest.1704869.
- Patel A, Mitchell J, Ryu C. A Quality Improvement Survey Assessment of Resident Physician Management With End of Life Care. CHEST Journal 2013, 144: 533a-533b. DOI: 10.1378/chest.1705191.
- Singh S, Ulahannan J, Dalal P, Humphreys D, Mitchell J, Ryu C. A Multidisciplinary Initiative to Improve Transitions of Care for Veterans With Congestive Heart Failure to Reduce Hospital Readmissions and Lengths of Stay. CHEST Journal 2013, 144: 539a-539b. DOI: 10.1378/chest.1705046.
- Lutchmansingh D, Ryu C, Amzuta I. The Path Less Traveled: Bilateral Pneumothoraces as a Complication of Endoscopic Retrograde Cholangiopancreatography. CHEST Journal 2013, 144: 494a-494b. DOI: 10.1378/chest.1671537.
- Lutchmansingh D, Ryu C, Nadkarni A. Aurora's Harbinger: Chylothorax as the Initial Presentation of Metastatic Pancreatic Cancer. CHEST Journal 2013, 144: 601a-601b. DOI: 10.1378/chest.1695111.
- Ryu C, Bramley K, Boffa D, Pisani M, Puchalski J. Endobronchial Treatment of Pulsatile Hemoptysis Complicating Y-Stent Management of Tracheobronchomalacia. CHEST Journal 2013, 144: 46a-46b. DOI: 10.1378/chest.1698542.
Locations
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473
Titles
- Assistant Professor
Education & Training
- MDNew York Medical College (2008)
- MPHDartmouth College (2004)
- BSEmory University (2003)
Additional Information
Honors & Recognitions
- 1K08HL151970-01: NIH/NHLBI (2020)
- John R. Addrizzo, MD, FCCP Research Grant in Sarcoidosis Award: Chest Foundation (2020)
- Boehringer Ingelheim IPF/ILD Discovery Award: Boehringer Ingelheim (2019)
- Recognition of Early Academic Achievement Award: American Thoracic Society (2018)
- Parker B. Francis Foundation Award: Parker B. Francis Foundation (2018)
- Foundation for Sarcoidosis Research Award: Foundation of Sarcoidosis Research (2017)
- Respiratory Disease Young Investigators' Award: National Jewish Health (2016)
Professional Service
- Graduate Medical Education Committee (2015 - 2016): Member
Publications
- Fiorini V, Hu B, Sun Y, Yu S, McGovern J, Gandhi S, Woo S, Turcotte-Foster S, Pivarnik T, Khan Z, Adams T, Herzog E, Kaminski N, Gulati M, Ryu C. Circulating Mitochondrial DNA is associated with High Levels of Fatigue in Two Independent Sarcoidosis Cohorts. CHEST Journal 2023 PMID: 37977267, DOI: 10.1016/j.chest.2023.11.020.
- Woo S, Gandhi S, Ghincea A, Saber T, Lee C, Ryu C. Targeting the NLRP3 inflammasome and associated cytokines in scleroderma associated interstitial lung disease. Frontiers In Cell And Developmental Biology 2023, 11: 1254904. PMID: 37849737, PMCID: PMC10577231, DOI: 10.3389/fcell.2023.1254904.
- Schupp J, Manning E, Chioccioli M, Kamp J, Christian L, Ryu C, Herzog E, Kühnel M, Prasse A, Kaminski N, Jonigk D, Homer R, Neubert L, Ius F, stringJustet A, Hariri L, Seeliger B, Welte T, Knipe R, Gottlieb J. Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 819-822. PMID: 37552025, PMCID: PMC10563189, DOI: 10.1164/rccm.202303-0544le.
- Çakan E, Kioon M, Garcia-Carmona Y, Glauzy S, Oliver D, Yamakawa N, Loza A, Du Y, Schickel J, Boeckers J, Yang C, Baldo A, Ivashkiv L, Young R, Staudt L, Moody K, Nündel K, Marshak-Rothstein A, van der Made C, Hoischen A, Hayward A, Rossato M, Radstake T, Cunningham-Rundles C, Ryu C, Herzog E, Barrat F, Meffre E. TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance. Journal Of Experimental Medicine 2023, 220: e20230944. PMID: 37773045, PMCID: PMC10541333, DOI: 10.1084/jem.20230944.
- Ghincea A, Woo S, Yu S, Pivarnik T, Fiorini V, Herzog E, Ryu C. Mitochondrial DNA-Sensing Pathogen Recognition Receptors in Systemic Sclerosis-Associated Interstitial Lung Disease: a Review. Current Treatment Options In Rheumatology 2023, 9: 204-220. PMID: 38230363, PMCID: PMC10791121, DOI: 10.1007/s40674-023-00211-1.
- Yu S, Woo S, Hu B, Sun Y, Fiorini V, Van Horn C, Gunes B, Hinchcliff M, Varga J, Herzog E, Ryu C. Elevated Levels of Mitochondrial DNA and CGAS Ligands Are Found in Scleroderma Associated Interstitial Lung Disease and Mediate Fibroblast Activation. 2023, a2279-a2279. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2279.
- Fiorini V, Hu B, Sun Y, Yu S, McGovern J, Woo S, Khan Z, Adams T, Pivarnik T, Herzog E, Ryu C. Plasma Mitochondrial DNA Is Associated With Patient-related Outcome Measures in Sarcoidosis. 2023, a2275-a2275. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2275.
- Ryu C, Sand J, Juhl P, Jessen H, Leeming D, Hu B, Sun Y, Adams T, Pivarnik T, Yu S, Woo S, McGovern J, Fiorini V, Goobie G, Zhang Y, Herzog E. Serum Collagen Neoepitopes Are Associated With Multi-organ Disease in the Access and GRADS Sarcoidosis Cohorts. 2023, a2242-a2242. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2242.
- Ryu C, Hu B, Sun Y, Yu S, Woo S, Fiorini V, Pivarnik T, Mcgovern J, Peng X, Herzog E, Trujillo G. Mitochondrial DNA-toll-like Receptor 9 Interactions Drives Fibrosis in the Adult Lung. 2023, a1376-a1376. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1376.
- Lee C, He C, Park J, Lee J, Kamle S, Ma B, Akosman B, Cotez R, Chen E, Zhou Y, Herzog E, Ryu C, Peng X, Rosas I, Poli S, Bostwick C, Choi A, Elias J, Lee C. Correction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Science Alliance 2023, 6: e202302065. PMID: 37037591, PMCID: PMC10088146, DOI: 10.26508/lsa.202302065.
- Ahangari F, Price N, Malik S, Chioccioli M, Bärnthaler T, Adams T, Kim J, Pradeep S, Ding S, Cosme C, Rose K, McDonough J, Aurelien N, Ibarra G, Omote N, Schupp J, DeIuliis G, Nunez J, Sharma L, Ryu C, Dela Cruz C, Liu X, Prasse A, Rosas I, Bahal R, Fernandez-Hernando C, Kaminski N. microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight 2023, 8: e158100. PMID: 36626225, PMCID: PMC9977502, DOI: 10.1172/jci.insight.158100.
- Ishikawa G, Peng X, McGovern J, Woo S, Perry C, Liu A, Yu S, Ghincea A, Kishchanka A, Fiorini V, Hu B, Sun Y, Sun H, Ryu C, Herzog E. α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2023, 324: l639-l651. PMID: 36648147, PMCID: PMC10110730, DOI: 10.1152/ajplung.00119.2022.
- FIORINI V, MCGOVERN J, HU B, SUN Y, KHAN Z, HERZOG E, RYU C. PATIENT-RELATED OUTCOMES AND BIOLOGIC MEDIATORS OF SARCOIDOSIS. CHEST Journal 2022, 162: a2692. DOI: 10.1016/j.chest.2022.08.2191.
- Ryan SM, Mroz MM, Herzog EL, Ryu C, Fingerlin TE, Maier LA, Gulati M. Occupational and environmental exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study. Respiratory Medicine 2022, 200: 106923. PMID: 35932543, DOI: 10.1016/j.rmed.2022.106923.
- Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis. Nature Communications 2022, 13: 3140. PMID: 35668129, PMCID: PMC9170782, DOI: 10.1038/s41467-022-30615-x.
- Liu A, Sharma L, Yan X, Dela Cruz CS, Herzog EL, Ryu C. Emerging insights in sarcoidosis: moving forward through reverse translational research. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2022, 322: l518-l525. PMID: 35196896, PMCID: PMC8957321, DOI: 10.1152/ajplung.00266.2021.
- Ghincea A, Ryu C, Herzog EL. An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination A Case Report. CHEST Journal 2022, 161: e71-e73. PMID: 35131075, PMCID: PMC8814523, DOI: 10.1016/j.chest.2021.07.2160.
- Glauzy S, Olson B, May CK, Parisi D, Massad C, Hansen JE, Ryu C, Herzog EL, Meffre E. Defective Early B Cell Tolerance Checkpoints in Patients With Systemic Sclerosis Allow the Production of Self Antigen–Specific Clones. Arthritis & Rheumatology 2021, 74: 307-317. PMID: 34279059, PMCID: PMC8766600, DOI: 10.1002/art.41927.
- Pednekar P, Amoah K, Homer R, Ryu C, Lutchmansingh DD. Case Report: Bullous Lung Disease Following COVID-19. Frontiers In Medicine 2021, 8: 770778. PMID: 34869488, PMCID: PMC8635639, DOI: 10.3389/fmed.2021.770778.
- Pednekar P, Amoah K, homer R, Ryu C, Lutchmansingh D. BULLOUS LUNG DISEASE FOLLOWING COVID-19 INFECTION. CHEST Journal 2021, 160: a356. PMCID: PMC8503349, DOI: 10.1016/j.chest.2021.07.358.
- Zhao A, Unterman A, Schupp J, Adams T, Sumida T, Ryu C, DeIuliis G, Yan X, Hafler D, Dela Cruz C, Herzog E, Kaminski N. Comparative scRNA-seq Analysis of Peripheral Blood Mononuclear Cells from Patients with COVID-19 and Idiopathic Pulmonary Fibrosis Demonstrates Dissimilar Cell Shifts and Gene Expression Profiles. 2021, a4361-a4361. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4361.
- Minasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog E, Dela Cruz C, Ryu C. IL-15 Is Independent of Pulmonary Sarcoid Granuloma Formation In Vivo. 2021, a4263-a4263. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4263.
- Minasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Liu A, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog EL, Dela Cruz CS, Ryu C. Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2021, 320: l1137-l1146. PMID: 33851886, PMCID: PMC8285626, DOI: 10.1152/ajplung.00575.2020.
- Ryu C, Walia A, Ortiz V, Perry C, Woo S, Reeves BC, Sun H, Winkler J, Kanyo JE, Wang W, Vukmirovic M, Ristic N, Stratton EA, Meena SR, Minasyan M, Kurbanov D, Liu X, Lam TT, Farina G, Gomez JL, Gulati M, Herzog EL. Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma‐Associated Interstitial Lung Disease. Arthritis & Rheumatology 2020, 72: 1905-1915. PMID: 32602227, PMCID: PMC8081728, DOI: 10.1002/art.41418.
- Sakamoto K, Furukawa T, Yamano Y, Kataoka K, Teramachi R, Walia A, Suzuki A, Inoue M, Nakahara Y, Ryu C, Hashimoto N, Kondoh Y. Serum mitochondrial DNA predicts the risk of acute exacerbation and progression of idiopathic pulmonary fibrosis. European Respiratory Journal 2020, 57: 2001346. PMID: 32855220, PMCID: PMC8177039, DOI: 10.1183/13993003.01346-2020.
- Walia A, Singh I, Ryu C, Lutchmansingh DD. A 50-Year-Old Woman With Limited Scleroderma Presenting With Shortness of Breath. CHEST Journal 2020, 158: e37-e40. PMID: 32654737, PMCID: PMC8097629, DOI: 10.1016/j.chest.2020.02.041.
- Chen W, Karhadkar TR, Ryu C, Herzog EL, Gomer RH. Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis. ImmunoHorizons 2020, 4: 352-362. PMID: 32576593, PMCID: PMC8500545, DOI: 10.4049/immunohorizons.2000043.
- Khan Z, Carrano D, Minasyan M, Gulati M, Ryu C, Herzog E. Rationale, Design, and Results of the Idiopathic Pulmonary Fibrosis "Sadokine" Pilot Study. 2020, a6580-a6580. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6580.
- Minasyan M, Herzog E, Dela Cruz C, Ryu C. IL-15 Is Elevated in the Bronchoalveolar Lavage of Patients with Pulmonary Sarcoidosis. 2020, a3108-a3108. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3108.
- Unterman A, Neumark N, Zhao A, Schupp J, Ryu C, Antin-Ozerkis D, Winkler J, Herazo-Maya J, Herzog E, Kaminski N. Single Cell RNA Sequencing of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis Reveals the Cellular Origin of the Outcome Predictive 52-Gene Signature. 2020, a6211-a6211. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6211.
- Perry C, Gao R, Peng X, Ntokou A, Ryu C, Gomez J, Reeves B, Walia A, Sun H, Black K, Hariri L, Moore M, Gulati M, Homer R, Greif D, Eltzschig H, Herzog E. Adrenergic Nerve-Associated Lung Fibrosis Is Driven by Myeloid Netrin-1. 2020, a2410-a2410. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2410.
- Zhang Y, Jiang M, Nouraie M, Roth MG, Tabib T, Winters S, Chen X, Sembrat J, Chu Y, Cardenes N, Tuder RM, Herzog EL, Ryu C, Rojas M, Lafyatis R, Gibson KF, McDyer JF, Kass DJ, Alder JK. GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2019, 317: l510-l521. PMID: 31432710, PMCID: PMC6842909, DOI: 10.1152/ajplung.00062.2019.
- Ryu C, Brandsdorfer C, Adams T, Hu B, Kelleher DW, Yaggi M, Manning EP, Walia A, Reeves B, Pan H, Winkler J, Minasyan M, Dela Cruz CS, Kaminski N, Gulati M, Herzog EL. Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis. European Respiratory Journal 2019, 54: 1801762. PMID: 31273041, PMCID: PMC8088542, DOI: 10.1183/13993003.01762-2018.
- Manning EP, Losier A, Emeagwali N, Ryu C, Honiden S. New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 1561-1563. PMID: 30822095, PMCID: PMC7051474, DOI: 10.1164/rccm.201809-1700rr.
- Lee CM, He CH, Park JW, Lee JH, Kamle S, Ma B, Akosman B, Cotez R, Chen E, Zhou Y, Herzog EL, Ryu C, Peng X, Rosas IO, Poli S, Bostwick CF, Choi AM, Elias JA, Lee CG. Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Science Alliance 2019, 2: e201900350. PMID: 31085559, PMCID: PMC6516052, DOI: 10.26508/lsa.201900350.
- Ryu C, Sun H, Winkler J, Meena S, Walia A, Minasyan M, Brandsdorfer C, Gulati M, Peng X, Herzog E. Circulating Mitochondrial DNA Is Associated with Fibroblast Activation and Disease Progression in Scleroderma Associated Interstitial Lung Disease. 2019, a7219-a7219. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7219.
- Xie Y, Ostriker AC, Jin Y, Hu H, Sizer AJ, Peng G, Morris AH, Ryu C, Herzog EL, Kyriakides T, Zhao H, Dardik A, Yu J, Hwa J, Martin KA. LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis. Circulation 2019, 139: 679-693. PMID: 30586711, PMCID: PMC6371979, DOI: 10.1161/circulationaha.118.034615.
- Tzouvelekis A, Herazo‐Maya J, Ryu C, Chu J, Zhang Y, Gibson KF, Adonteng‐Boateng P, Li Q, Pan H, Cherry B, Ahmad F, Ford HJ, Herzog EL, Kaminski N, Fares WH. S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension. Respirology 2018, 23: 771-779. PMID: 29611244, PMCID: PMC6047907, DOI: 10.1111/resp.13302.
- Ryu C, Boffa D, Bramley K, Pisani M, Puchalski J. A novel endobronchial approach to massive hemoptysis complicating silicone Y-stent placement for tracheobronchomalacia. Medicine 2018, 97: e9980. PMID: 29465600, PMCID: PMC5842006, DOI: 10.1097/md.0000000000009980.
- Murray LA, Habiel DM, Hohmann M, Camelo A, Shang H, Zhou Y, Coelho AL, Peng X, Gulati M, Crestani B, Sleeman MA, Mustelin T, Moore MW, Ryu C, Osafo-Addo AD, Elias JA, Lee CG, Hu B, Herazo-Maya JD, Knight DA, Hogaboam CM, Herzog EL. Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis. JCI Insight 2017, 2: e92192. PMID: 28814671, PMCID: PMC5621899, DOI: 10.1172/jci.insight.92192.
- Ryu C, Sun H, Gulati M, Herazo-Maya J, Chen Y, Osafo-Addo A, Brandsdorfer C, Winkler J, Blaul C, Faunce J, Pan H, Woolard T, Tzouvelekis A, Antin-Ozerkis DE, Puchalski JT, Slade M, Gonzalez AL, Bogenhagen DF, Kirillov V, Feghali-Bostwick C, Gibson K, Lindell K, Herzog RI, Dela Cruz CS, Mehal W, Kaminski N, Herzog EL, Trujillo G. Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2017, 196: 1571-1581. PMID: 28783377, PMCID: PMC5754440, DOI: 10.1164/rccm.201612-2480oc.
- Ryu C, Herzog EL, Pan H, Homer R, Gulati M. Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report. American Journal Of Case Reports 2017, 18: 157-159. PMID: 28190872, PMCID: PMC5319306, DOI: 10.12659/ajcr.902231.
- Tzouvelekis A, Herazo‐Maya J, Slade M, Chu J, Deiuliis G, Ryu C, Li Q, Sakamoto K, Ibarra G, Pan H, Gulati M, Antin‐Ozerkis D, Herzog EL, Kaminski N. Validation of the prognostic value of MMP‐7 in idiopathic pulmonary fibrosis. Respirology 2016, 22: 486-493. PMID: 27761978, PMCID: PMC5352520, DOI: 10.1111/resp.12920.
- Peng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, Herazo‐Maya J, Kaminski N, Hu X, Pan H, Ryu C, Osafo‐Addo A, Homer RJ, Feghali‐Bostwick C, Fares W, Gulati M, Hu B, Lee C, Elias JA, Herzog EL. Plexin C1 deficiency permits synaptotagmin 7–mediated macrophage migration and enhances mammalian lung fibrosis. The FASEB Journal 2016, 30: 4056-4070. PMID: 27609773, PMCID: PMC5102121, DOI: 10.1096/fj.201600373r.
- Ryu C, Homer RJ, Herzog EL. The Airway in Idiopathic Pulmonary Fibrosis: Protecting the Lung or Promoting Disease? American Journal Of Respiratory And Critical Care Medicine 2016, 193: 1081-1082. PMID: 27174477, PMCID: PMC4872674, DOI: 10.1164/rccm.201601-0055ed.
- Ryu C, Puchalski J, Perkins M, Honiden S. Management of an elderly patient with respiratory failure due to double aortic arch. Respiratory Medicine Case Reports 2015, 17: 37-39. PMID: 27222782, PMCID: PMC4821450, DOI: 10.1016/j.rmcr.2015.12.002.
- Lutchmansingh D, Ryu C, Lenox R. 1260. Critical Care Medicine 2013, 41: a324. DOI: 10.1097/01.ccm.0000440492.30842.15.
- Dalal P, Singh S, Ulahanan J, Ryu C, Mitchell J, Humpheries D. A Quality Improvement Project to Reduce Congestive Heart Failure Mortality With Intensive Case Management. CHEST Journal 2013, 144: 404a-404b. DOI: 10.1378/chest.1704688.
- Ulahannan J, Singh S, Dalal P, Humphreys D, Mitchell J, Ryu C. A Collaborative Initiative to Utilize Telehealth Medicine for Veterans With Congestive Heart Failure to Reduce Hospital Readmissions. CHEST Journal 2013, 144: 535a-535b. DOI: 10.1378/chest.1704869.
- Patel A, Mitchell J, Ryu C. A Quality Improvement Survey Assessment of Resident Physician Management With End of Life Care. CHEST Journal 2013, 144: 533a-533b. DOI: 10.1378/chest.1705191.
- Singh S, Ulahannan J, Dalal P, Humphreys D, Mitchell J, Ryu C. A Multidisciplinary Initiative to Improve Transitions of Care for Veterans With Congestive Heart Failure to Reduce Hospital Readmissions and Lengths of Stay. CHEST Journal 2013, 144: 539a-539b. DOI: 10.1378/chest.1705046.
- Lutchmansingh D, Ryu C, Amzuta I. The Path Less Traveled: Bilateral Pneumothoraces as a Complication of Endoscopic Retrograde Cholangiopancreatography. CHEST Journal 2013, 144: 494a-494b. DOI: 10.1378/chest.1671537.
- Lutchmansingh D, Ryu C, Nadkarni A. Aurora's Harbinger: Chylothorax as the Initial Presentation of Metastatic Pancreatic Cancer. CHEST Journal 2013, 144: 601a-601b. DOI: 10.1378/chest.1695111.
- Ryu C, Bramley K, Boffa D, Pisani M, Puchalski J. Endobronchial Treatment of Pulsatile Hemoptysis Complicating Y-Stent Management of Tracheobronchomalacia. CHEST Journal 2013, 144: 46a-46b. DOI: 10.1378/chest.1698542.
Locations
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473