1
1 of 2
- Yale Pediatric Endocrinology1 Long Wharf DriveSte 503New Haven, CT 06511
- Yale Pediatric EndocrinologyGreenwich Hospital5 Perryridge RdGreenwich, CT 06830
Brian Feldman, MD, PhD
Patient type treated
Child
Accepting new patients
No
Referral required
Not Applicable
Biography
Brian Feldman, MD, PhD, is a pediatric endocrinologist who specializes in treating hormonal disorders in children, including diabetes and conditions affecting growth and metabolism. He employs a comprehensive approach to care, using his expertise to improve the lives of young patients with complex endocrine challenges.
As the C.N.H. Long Professor of Pediatrics (endocrinology) at Yale School of Medicine, Dr. Feldman conducts research on the role of steroid hormones in determining cell fate, with particular interest in obesity, type 2 diabetes, and the development of brown fat. His work aims to uncover new treatment pathways for metabolic conditions and has garnered significant recognition, including prestigious awards such as the Clinical Scholars Award from the Pediatric Endocrine Society and the NIH Director’s New Innovator Award.
Dr. Feldman received his medical and doctoral degrees from Stanford University. He completed his residency in pediatrics at Harvard University-affiliated Boston Children’s Hospital and pursued a fellowship in pediatric endocrinology at the University of California, San Francisco.
Titles
- C.N.H. Long Professor of Pediatrics (Endocrinology)
- Section Chief, Pediatric Endocrinology & Diabetes
Education & Training
- Pediatric Endocrinology FellowshipUniversity of California, San Francisco (UCSF)
- ResidentHarvard University/ Boston Children's Hospital
- MDStanford University
- PhDStanford University
- MDStanford University School of Medicine
- ResidencyBoston Children's Hospital
- FellowshipUniversity of California at San Francisco School of Medicine
Additional Information
Publications
- Li L, Feldman B. Characterization and lineage tracing of a mouse adipose depot reveal properties conserved with human supraclavicular brown adipose tissue. Stem Cell Reports 2025, 20: 102509. PMID: 40409261, PMCID: PMC12181967, DOI: 10.1016/j.stemcr.2025.102509.
- Li L, Feldman B. White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models. Journal Of Clinical Investigation 2024, 134: e172360. PMID: 38949025, PMCID: PMC11213504, DOI: 10.1172/jci172360.
- Rodrigues A, Chernikova S, Wang Y, Trinh T, Solow-Cordero D, Alexandrova L, Casey K, Alli E, Aggarwal A, Quill T, Koegel A, Feldman B, Ford J, Hayden-Gephart M. Repurposing mebendazole against triple-negative breast cancer CNS metastasis. Journal Of Neuro-Oncology 2024, 168: 125-138. PMID: 38563850, PMCID: PMC11093727, DOI: 10.1007/s11060-024-04654-x.
- Babel N, Feldman B. Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo. Steroids 2023, 201: 109336. PMID: 37944652, PMCID: PMC11005958, DOI: 10.1016/j.steroids.2023.109336.
- Li L, Gunewardena A, Nyima T, Feldman B. Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown. STAR Protocols 2023, 4: 102607. PMID: 37742183, PMCID: PMC10751552, DOI: 10.1016/j.xpro.2023.102607.
- Chen M, Kim S, Li L, Chattopadhyay S, Rando T, Feldman B. Identification of an adipose tissue-resident pro-preadipocyte population. Cell Reports 2023, 42: 112440. PMID: 37119138, PMCID: PMC10370484, DOI: 10.1016/j.celrep.2023.112440.
- Cheung S, Sayeed M, Nakuluri K, Li L, Feldman B. MYH9 facilitates autoregulation of adipose tissue depot development. JCI Insight 2021, 6: e136233. PMID: 33986190, PMCID: PMC8262332, DOI: 10.1172/jci.insight.136233.
- Miller W, Flück C, Breault D, Feldman B. 14 The Adrenal Cortex and Its Disorders. 2021, 425-490. DOI: 10.1016/b978-0-323-62520-3.00014-2.
- Feldman B, Sayeed M, Nakuluri K. SAT-585 Autoregulation of Adipose Tissue Development. Journal Of The Endocrine Society 2020, 4: sat-585. PMCID: PMC7209260, DOI: 10.1210/jendso/bvaa046.389.
- Huang Y, Zhao N, Wang Y, Truillet C, Wei J, Blecha J, VanBrocklin H, Seo Y, Sayeed M, Feldman B, Aggarwal R, Behr S, Shao H, Wilson D, Villanueva-Meyer J, Gestwicki J, Evans M. A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography. ACS Chemical Biology 2020, 15: 1381-1391. PMID: 32255605, PMCID: PMC8031368, DOI: 10.1021/acschembio.9b01043.
- Carter K, Treurnicht A, Davis K, Kumar R, Feldman B. A novel platform for isotype-specific testing of autoantibodies. PLOS ONE 2019, 14: e0211596. PMID: 30730939, PMCID: PMC6366878, DOI: 10.1371/journal.pone.0211596.
- Jung Y, Feldman B. A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis. Adipocyte 2018, 7: 273-276. PMID: 30153756, PMCID: PMC6768266, DOI: 10.1080/21623945.2018.1516099.
- Aggarwal A, Costa M, Rivero-Gutiérrez B, Ji L, Morgan S, Feldman B. The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15. Cell Reports 2017, 21: 2367-2375. PMID: 29186676, PMCID: PMC5728416, DOI: 10.1016/j.celrep.2017.11.004.
- Du H, Shih C, Wosczyna M, Mueller A, Cho J, Aggarwal A, Rando T, Feldman B. Macrophage-released ADAMTS1 promotes muscle stem cell activation. Nature Communications 2017, 8: 669. PMID: 28939843, PMCID: PMC5610267, DOI: 10.1038/s41467-017-00522-7.
- Wong J, Feldman B. Adamts1 responds to systemic cues and gates adipogenesis. Adipocyte 2017, 6: 293-297. PMID: 28700319, PMCID: PMC5736246, DOI: 10.1080/21623945.2017.1322746.
- Aggarwal A, Feldman D, Feldman B. Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression. The Journal Of Steroid Biochemistry And Molecular Biology 2017, 177: 155-158. PMID: 28710021, PMCID: PMC5764828, DOI: 10.1016/j.jsbmb.2017.07.003.
- Chen P, Cao A, Miyagawa K, Tojais N, Hennigs J, Li C, Sweeney N, Inglis A, Wang L, Li D, Ye M, Feldman B, Rabinovitch M. Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension. JCI Insight 2017, 2: e90427. PMID: 28138562, PMCID: PMC5256132, DOI: 10.1172/jci.insight.90427.
- Feldman B, VanHook A. Science Signaling Podcast for 25 October 2016: How glucocorticoids stimulate fat. Science Signaling 2016, 9 DOI: 10.1126/scisignal.aal1653.
- Wong J, Krueger K, Costa M, Aggarwal A, Du H, McLaughlin T, Feldman B. A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Science Signaling 2016, 9: ra103. PMID: 27811141, PMCID: PMC8087215, DOI: 10.1126/scisignal.aag0487.
- Williams J, Aggarwal A, Swami S, Krishnan A, Ji L, Albertelli M, Feldman B. Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis. Endocrinology 2016, 157: 1341-1347. PMID: 26934299, PMCID: PMC4816742, DOI: 10.1210/en.2015-2036.
- Swami S, Krishnan A, Williams J, Aggarwal A, Albertelli M, Horst R, Feldman B, Feldman D. Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocrine Related Cancer 2016, 23: 251-264. PMID: 26817629, PMCID: PMC4889430, DOI: 10.1530/erc-15-0557.
- Banerjee R, Marina N, Katznelson L, Feldman B. Mifepristone Treatment of Cushing’s Syndrome in a Pediatric Patient. 2015, 136: e1377-e1381. PMID: 26459648, DOI: 10.1542/peds.2015-0684.
- Ji L, Gupta M, Feldman B. Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3. Endocrinology 2015, 157: 91-97. PMID: 26488808, PMCID: PMC4701879, DOI: 10.1210/en.2015-1674.
- Jeong Y, Swami S, Krishnan A, Williams J, Martin S, Horst R, Albertelli M, Feldman B, Feldman D, Diehn M. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. Molecular Cancer Therapeutics 2015, 14: 1951-1961. PMID: 25934710, PMCID: PMC4549392, DOI: 10.1158/1535-7163.mct-15-0066.
- Ota A, Kovary K, Wu O, Ahrends R, Shen W, Costa M, Feldman B, Kraemer F, Teruel M. Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice. Journal Of Lipid Research 2015, 56: 1068-1078. PMID: 25840986, PMCID: PMC4409283, DOI: 10.1194/jlr.d056317.
- Diebold I, Hennigs J, Miyagawa K, Li C, Nickel N, Kaschwich M, Cao A, Wang L, Reddy S, Chen P, Nakahira K, Alcazar M, Hopper R, Ji L, Feldman B, Rabinovitch M. BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension. Cell Metabolism 2015, 21: 596-608. PMID: 25863249, PMCID: PMC4394191, DOI: 10.1016/j.cmet.2015.03.010.
- Chao C, McKnight K, Cox K, Chang A, Kim S, Feldman B. Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations. PLOS ONE 2015, 10: e0118449. PMID: 25706805, PMCID: PMC4338276, DOI: 10.1371/journal.pone.0118449.
- Kumar R, Gupta M, Feldman B. The development of next-generation screening and diagnostic platforms will change diabetes care. Expert Review Of Molecular Diagnostics 2015, 15: 291-294. PMID: 25583407, PMCID: PMC4627787, DOI: 10.1586/14737159.2015.1002468.
- Krueger K, Costa M, Du H, Feldman B. Characterization of Cre Recombinase Activity for In Vivo Targeting of Adipocyte Precursor Cells. Stem Cell Reports 2014, 3: 1147-1158. PMID: 25458893, PMCID: PMC4264060, DOI: 10.1016/j.stemcr.2014.10.009.
- Zhang B, Kumar R, Dai H, Feldman B. A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes. Nature Medicine 2014, 20: 948-953. PMID: 25038825, PMCID: PMC4736508, DOI: 10.1038/nm.3619.
- Feldman D, Krishnan A, Swami S, Giovannucci E, Feldman B. The role of vitamin D in reducing cancer risk and progression. Nature Reviews Cancer 2014, 14: 342-357. PMID: 24705652, DOI: 10.1038/nrc3691.
- Malloy P, Feldman B. Cell-Autonomous Regulation of Brown Fat Identity Gene UCP1 by Unliganded Vitamin D Receptor. Endocrinology 2013, 27: 1632-1642. PMID: 23906633, PMCID: PMC3787131, DOI: 10.1210/me.2013-1037.
- Armstrong S, Seeber R, Ayoub M, Feldman B, Pfleger K. Characterization of Three Vasopressin Receptor 2 Variants: An Apparent Polymorphism (V266A) and Two Loss-of-Function Mutations (R181C and M311V). PLOS ONE 2013, 8: e65885. PMID: 23762448, PMCID: PMC3675069, DOI: 10.1371/journal.pone.0065885.
- Krueger K, Feldman B. Adipose circadian clocks: coordination of metabolic rhythms by clock genes, steroid hormones, and PPARs. Hormone Molecular Biology And Clinical Investigation 2013, 14: 15-24. PMID: 25436716, DOI: 10.1515/hmbci-2013-0011.
- Costa M, So A, Kaasik K, Krueger K, Pillsbury M, Fu Y, Ptacek L, Yamamoto K, Feldman B. Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate*. Journal Of Biological Chemistry 2011, 286: 9063-9070. PMID: 21228270, PMCID: PMC3058992, DOI: 10.1074/jbc.m110.164558.
- Kocan M, Dalrymple M, Seeber R, Feldman B, Pfleger K. Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins. Frontiers In Endocrinology 2010, 1: 12. PMID: 22654789, PMCID: PMC3356007, DOI: 10.3389/fendo.2010.00012.
- So A, Bernal T, Pillsbury M, Yamamoto K, Feldman B. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17582-17587. PMID: 19805059, PMCID: PMC2757402, DOI: 10.1073/pnas.0909733106.
- Kocan M, See H, Sampaio N, Eidne K, Feldman B, Pfleger K. Agonist-Independent Interactions between β-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis. The Journal Of Clinical Endocrinology & Metabolism 2009, 94: 1475-1475. DOI: 10.1210/jcem.94.4.9993.
- Feldman B. Glucocorticoids Influence on Mesenchymal Stem Cells and Implications for Metabolic Disease. Pediatric Research 2009, 65: 249-251. PMID: 19262295, PMCID: PMC2716735, DOI: 10.1203/pdr.0b013e3181909c08.
- Kocan M, See H, Sampaio N, Eidne K, Feldman B, Pfleger K. Agonist-Independent Interactions between β-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis. Endocrinology 2009, 23: 559-571. PMID: 19179480, PMCID: PMC2667710, DOI: 10.1210/me.2008-0321.
- So A, Cooper S, Feldman B, Manuchehri M, Yamamoto K. Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 5745-5749. PMID: 18408151, PMCID: PMC2311370, DOI: 10.1073/pnas.0801551105.
- Feldman B. Is Your Metabolism Determined By (Cell) Fate? Pediatric Research 2007, 61: 636-639. PMID: 17426662, DOI: 10.1203/pdr.0b013e31805d854e.
- Rosenthal S, Gitelman S, Vargas G, Feldman B. Gain-of-Function Mutations in the V2 Vasopressin Receptor. Hormone Research In Paediatrics 2007, 67: 121-125. DOI: 10.1159/000097567.
- Bremer A, Feldman B, Iezza G, Clark O, Rosenthal S. Report of a Hürthle Cell Neoplasm in a Peripubertal Girl. Thyroid 2007, 17: 175-178. PMID: 17316121, DOI: 10.1089/thy.2006.0214.
- Fortescue E, Shin A, Greenes D, Mannix R, Agarwal S, Feldman B, Shah M, Rifai N, Landzberg M, Newburger J, Almond C. Cardiac Troponin Increases Among Runners in the Boston Marathon. Annals Of Emergency Medicine 2006, 49: 137-143.e1. PMID: 17145114, DOI: 10.1016/j.annemergmed.2006.09.024.
- Rosenthal S, Feldman B, Vargas G, Gitelman S. Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatric Endocrinology Reviews : PER 2006, 4 Suppl 1: 66-70. PMID: 17261972.
- Feldman B, Streeper R, Farese R, Yamamoto K. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 15675-15680. PMID: 17030820, PMCID: PMC1592529, DOI: 10.1073/pnas.0607501103.
- Gitelman S, Feldman B, Rosenthal S. Nephrogenic Syndrome of Inappropriate Antidiuresis: A Novel Disorder in Water Balance in Pediatric Patients. The American Journal Of Medicine 2006, 119: s54-s58. PMID: 16843086, DOI: 10.1016/j.amjmed.2006.05.008.
- Huang E, Feldman B, Schwartz I, Geller D, Rosenthal S, Gitelman S. Oral Urea for the Treatment of Chronic Syndrome of Inappropriate Antidiuresis in Children. The Journal Of Pediatrics 2006, 148: 128-131. PMID: 16423613, DOI: 10.1016/j.jpeds.2005.08.031.
- Feldman B, Rosenthal S, Vargas G, Fenwick R, Huang E, Matsuda-Abedini M, Lustig R, Mathias R, Portale A, Miller W, Gitelman S. Nephrogenic Syndrome of Inappropriate Antidiuresis. The New England Journal Of Medicine 2005, 352: 1884-1890. PMID: 15872203, PMCID: PMC5340184, DOI: 10.1056/nejmoa042743.
- Feldman B, Rosenthal D. Carbohydrate-Deficient Glycoprotein Syndrome-Associated Pericardial Effusion Treated with Corticosteroids and Salicylic Acid. Pediatric Cardiology 2002, 23: 469-471. PMID: 12170369, DOI: 10.1007/s00246-002-1497-1.
- Feldman B, Feldman D. The development of androgen-independent prostate cancer. Nature Reviews Cancer 2001, 1: 34-45. PMID: 11900250, DOI: 10.1038/35094009.
- Feldman B, Hampton T, Cleary M. A carboxy-terminal deletion mutant of Notch1accelerates lymphoid oncogenesis in E2A-PBX1transgenic mice. Blood 2000, 96: 1906-1913. DOI: 10.1182/blood.v96.5.1906.
- Feldman B, Hampton T, Cleary M. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood 2000, 96: 1906-13. PMID: 10961893, DOI: 10.1182/blood.v96.5.1906.h8001906_1906_1913.
- Feldman B, Reid T, Cleary M. Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice. Oncogene 1997, 15: 2735-2742. PMID: 9401000, DOI: 10.1038/sj.onc.1201670.
- LeBrun D, Matthews B, Feldman B, Cleary M. The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. Oncogene 1997, 15: 2059-2067. PMID: 9366523, DOI: 10.1038/sj.onc.1201367.
- Feldman B, D'Alessandro A, Osterloh J, Hata B. Electrochemical determination of low blood lead concentrations with a disposable carbon microarray electrode. Clinical Chemistry 1995, 41: 557-563. PMID: 7720246, DOI: 10.1093/clinchem/41.4.557.
- Fox M, Feldman B, Chu G. A Novel Role for DNA Photolyase: Binding to DNA Damaged by Drugs Is Associated with Enhanced Cytotoxicity in Saccharomyces cerevisiae. Molecular And Cellular Biology 1994, 14: 8071-8077. DOI: 10.1128/mcb.14.12.8071-8077.1994.
- Fox M, Feldman B, Chu G. A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae. Molecular And Cellular Biology 1994, 14: 8071-8077. PMID: 7969145, PMCID: PMC359345, DOI: 10.1128/mcb.14.12.8071.
- Feldman B, Osterloh J, Hata B, D'Alessandro A. Determination of lead in blood by square wave anodic stripping voltammetry at a carbon disk ultramicroelectrode. Analytical Chemistry 1994, 66: 1983-7. PMID: 8067521, DOI: 10.1021/ac00085a010.
- Osterloh J, Feldman B. Urinary Protein Markers in Pesticide Applicators During a Chlorinated Hydrocarbon Exposure. Environmental Research 1993, 63: 171-181. PMID: 8243412, DOI: 10.1006/enrs.1993.1138.
- Feldman B, Mogadeddi H, Osterloh J. Determination of Pb2+ in water by isotope dilution gas chromatography-mass spectrometry of tetraethyllead formed by reaction with sodium tetraethylborate. Journal Of Chromatography A 1992, 594: 275-282. DOI: 10.1016/0021-9673(92)80340-z.
Departments and Programs
Locations
1
1 of 2
- Yale Pediatric Endocrinology1 Long Wharf DriveSte 503New Haven, CT 06511
- Yale Pediatric EndocrinologyGreenwich Hospital5 Perryridge RdGreenwich, CT 06830
Biography
Brian Feldman, MD, PhD, is a pediatric endocrinologist who specializes in treating hormonal disorders in children, including diabetes and conditions affecting growth and metabolism. He employs a comprehensive approach to care, using his expertise to improve the lives of young patients with complex endocrine challenges.
As the C.N.H. Long Professor of Pediatrics (endocrinology) at Yale School of Medicine, Dr. Feldman conducts research on the role of steroid hormones in determining cell fate, with particular interest in obesity, type 2 diabetes, and the development of brown fat. His work aims to uncover new treatment pathways for metabolic conditions and has garnered significant recognition, including prestigious awards such as the Clinical Scholars Award from the Pediatric Endocrine Society and the NIH Director’s New Innovator Award.
Dr. Feldman received his medical and doctoral degrees from Stanford University. He completed his residency in pediatrics at Harvard University-affiliated Boston Children’s Hospital and pursued a fellowship in pediatric endocrinology at the University of California, San Francisco.
Titles
- C.N.H. Long Professor of Pediatrics (Endocrinology)
- Section Chief, Pediatric Endocrinology & Diabetes
Education & Training
- Pediatric Endocrinology FellowshipUniversity of California, San Francisco (UCSF)
- ResidentHarvard University/ Boston Children's Hospital
- MDStanford University
- PhDStanford University
- MDStanford University School of Medicine
- ResidencyBoston Children's Hospital
- FellowshipUniversity of California at San Francisco School of Medicine
Additional Information
Publications
- Li L, Feldman B. Characterization and lineage tracing of a mouse adipose depot reveal properties conserved with human supraclavicular brown adipose tissue. Stem Cell Reports 2025, 20: 102509. PMID: 40409261, PMCID: PMC12181967, DOI: 10.1016/j.stemcr.2025.102509.
- Li L, Feldman B. White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models. Journal Of Clinical Investigation 2024, 134: e172360. PMID: 38949025, PMCID: PMC11213504, DOI: 10.1172/jci172360.
- Rodrigues A, Chernikova S, Wang Y, Trinh T, Solow-Cordero D, Alexandrova L, Casey K, Alli E, Aggarwal A, Quill T, Koegel A, Feldman B, Ford J, Hayden-Gephart M. Repurposing mebendazole against triple-negative breast cancer CNS metastasis. Journal Of Neuro-Oncology 2024, 168: 125-138. PMID: 38563850, PMCID: PMC11093727, DOI: 10.1007/s11060-024-04654-x.
- Babel N, Feldman B. Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo. Steroids 2023, 201: 109336. PMID: 37944652, PMCID: PMC11005958, DOI: 10.1016/j.steroids.2023.109336.
- Li L, Gunewardena A, Nyima T, Feldman B. Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown. STAR Protocols 2023, 4: 102607. PMID: 37742183, PMCID: PMC10751552, DOI: 10.1016/j.xpro.2023.102607.
- Chen M, Kim S, Li L, Chattopadhyay S, Rando T, Feldman B. Identification of an adipose tissue-resident pro-preadipocyte population. Cell Reports 2023, 42: 112440. PMID: 37119138, PMCID: PMC10370484, DOI: 10.1016/j.celrep.2023.112440.
- Cheung S, Sayeed M, Nakuluri K, Li L, Feldman B. MYH9 facilitates autoregulation of adipose tissue depot development. JCI Insight 2021, 6: e136233. PMID: 33986190, PMCID: PMC8262332, DOI: 10.1172/jci.insight.136233.
- Miller W, Flück C, Breault D, Feldman B. 14 The Adrenal Cortex and Its Disorders. 2021, 425-490. DOI: 10.1016/b978-0-323-62520-3.00014-2.
- Feldman B, Sayeed M, Nakuluri K. SAT-585 Autoregulation of Adipose Tissue Development. Journal Of The Endocrine Society 2020, 4: sat-585. PMCID: PMC7209260, DOI: 10.1210/jendso/bvaa046.389.
- Huang Y, Zhao N, Wang Y, Truillet C, Wei J, Blecha J, VanBrocklin H, Seo Y, Sayeed M, Feldman B, Aggarwal R, Behr S, Shao H, Wilson D, Villanueva-Meyer J, Gestwicki J, Evans M. A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography. ACS Chemical Biology 2020, 15: 1381-1391. PMID: 32255605, PMCID: PMC8031368, DOI: 10.1021/acschembio.9b01043.
- Carter K, Treurnicht A, Davis K, Kumar R, Feldman B. A novel platform for isotype-specific testing of autoantibodies. PLOS ONE 2019, 14: e0211596. PMID: 30730939, PMCID: PMC6366878, DOI: 10.1371/journal.pone.0211596.
- Jung Y, Feldman B. A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis. Adipocyte 2018, 7: 273-276. PMID: 30153756, PMCID: PMC6768266, DOI: 10.1080/21623945.2018.1516099.
- Aggarwal A, Costa M, Rivero-Gutiérrez B, Ji L, Morgan S, Feldman B. The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15. Cell Reports 2017, 21: 2367-2375. PMID: 29186676, PMCID: PMC5728416, DOI: 10.1016/j.celrep.2017.11.004.
- Du H, Shih C, Wosczyna M, Mueller A, Cho J, Aggarwal A, Rando T, Feldman B. Macrophage-released ADAMTS1 promotes muscle stem cell activation. Nature Communications 2017, 8: 669. PMID: 28939843, PMCID: PMC5610267, DOI: 10.1038/s41467-017-00522-7.
- Wong J, Feldman B. Adamts1 responds to systemic cues and gates adipogenesis. Adipocyte 2017, 6: 293-297. PMID: 28700319, PMCID: PMC5736246, DOI: 10.1080/21623945.2017.1322746.
- Aggarwal A, Feldman D, Feldman B. Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression. The Journal Of Steroid Biochemistry And Molecular Biology 2017, 177: 155-158. PMID: 28710021, PMCID: PMC5764828, DOI: 10.1016/j.jsbmb.2017.07.003.
- Chen P, Cao A, Miyagawa K, Tojais N, Hennigs J, Li C, Sweeney N, Inglis A, Wang L, Li D, Ye M, Feldman B, Rabinovitch M. Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension. JCI Insight 2017, 2: e90427. PMID: 28138562, PMCID: PMC5256132, DOI: 10.1172/jci.insight.90427.
- Feldman B, VanHook A. Science Signaling Podcast for 25 October 2016: How glucocorticoids stimulate fat. Science Signaling 2016, 9 DOI: 10.1126/scisignal.aal1653.
- Wong J, Krueger K, Costa M, Aggarwal A, Du H, McLaughlin T, Feldman B. A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Science Signaling 2016, 9: ra103. PMID: 27811141, PMCID: PMC8087215, DOI: 10.1126/scisignal.aag0487.
- Williams J, Aggarwal A, Swami S, Krishnan A, Ji L, Albertelli M, Feldman B. Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis. Endocrinology 2016, 157: 1341-1347. PMID: 26934299, PMCID: PMC4816742, DOI: 10.1210/en.2015-2036.
- Swami S, Krishnan A, Williams J, Aggarwal A, Albertelli M, Horst R, Feldman B, Feldman D. Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocrine Related Cancer 2016, 23: 251-264. PMID: 26817629, PMCID: PMC4889430, DOI: 10.1530/erc-15-0557.
- Banerjee R, Marina N, Katznelson L, Feldman B. Mifepristone Treatment of Cushing’s Syndrome in a Pediatric Patient. 2015, 136: e1377-e1381. PMID: 26459648, DOI: 10.1542/peds.2015-0684.
- Ji L, Gupta M, Feldman B. Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3. Endocrinology 2015, 157: 91-97. PMID: 26488808, PMCID: PMC4701879, DOI: 10.1210/en.2015-1674.
- Jeong Y, Swami S, Krishnan A, Williams J, Martin S, Horst R, Albertelli M, Feldman B, Feldman D, Diehn M. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. Molecular Cancer Therapeutics 2015, 14: 1951-1961. PMID: 25934710, PMCID: PMC4549392, DOI: 10.1158/1535-7163.mct-15-0066.
- Ota A, Kovary K, Wu O, Ahrends R, Shen W, Costa M, Feldman B, Kraemer F, Teruel M. Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice. Journal Of Lipid Research 2015, 56: 1068-1078. PMID: 25840986, PMCID: PMC4409283, DOI: 10.1194/jlr.d056317.
- Diebold I, Hennigs J, Miyagawa K, Li C, Nickel N, Kaschwich M, Cao A, Wang L, Reddy S, Chen P, Nakahira K, Alcazar M, Hopper R, Ji L, Feldman B, Rabinovitch M. BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension. Cell Metabolism 2015, 21: 596-608. PMID: 25863249, PMCID: PMC4394191, DOI: 10.1016/j.cmet.2015.03.010.
- Chao C, McKnight K, Cox K, Chang A, Kim S, Feldman B. Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations. PLOS ONE 2015, 10: e0118449. PMID: 25706805, PMCID: PMC4338276, DOI: 10.1371/journal.pone.0118449.
- Kumar R, Gupta M, Feldman B. The development of next-generation screening and diagnostic platforms will change diabetes care. Expert Review Of Molecular Diagnostics 2015, 15: 291-294. PMID: 25583407, PMCID: PMC4627787, DOI: 10.1586/14737159.2015.1002468.
- Krueger K, Costa M, Du H, Feldman B. Characterization of Cre Recombinase Activity for In Vivo Targeting of Adipocyte Precursor Cells. Stem Cell Reports 2014, 3: 1147-1158. PMID: 25458893, PMCID: PMC4264060, DOI: 10.1016/j.stemcr.2014.10.009.
- Zhang B, Kumar R, Dai H, Feldman B. A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes. Nature Medicine 2014, 20: 948-953. PMID: 25038825, PMCID: PMC4736508, DOI: 10.1038/nm.3619.
- Feldman D, Krishnan A, Swami S, Giovannucci E, Feldman B. The role of vitamin D in reducing cancer risk and progression. Nature Reviews Cancer 2014, 14: 342-357. PMID: 24705652, DOI: 10.1038/nrc3691.
- Malloy P, Feldman B. Cell-Autonomous Regulation of Brown Fat Identity Gene UCP1 by Unliganded Vitamin D Receptor. Endocrinology 2013, 27: 1632-1642. PMID: 23906633, PMCID: PMC3787131, DOI: 10.1210/me.2013-1037.
- Armstrong S, Seeber R, Ayoub M, Feldman B, Pfleger K. Characterization of Three Vasopressin Receptor 2 Variants: An Apparent Polymorphism (V266A) and Two Loss-of-Function Mutations (R181C and M311V). PLOS ONE 2013, 8: e65885. PMID: 23762448, PMCID: PMC3675069, DOI: 10.1371/journal.pone.0065885.
- Krueger K, Feldman B. Adipose circadian clocks: coordination of metabolic rhythms by clock genes, steroid hormones, and PPARs. Hormone Molecular Biology And Clinical Investigation 2013, 14: 15-24. PMID: 25436716, DOI: 10.1515/hmbci-2013-0011.
- Costa M, So A, Kaasik K, Krueger K, Pillsbury M, Fu Y, Ptacek L, Yamamoto K, Feldman B. Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate*. Journal Of Biological Chemistry 2011, 286: 9063-9070. PMID: 21228270, PMCID: PMC3058992, DOI: 10.1074/jbc.m110.164558.
- Kocan M, Dalrymple M, Seeber R, Feldman B, Pfleger K. Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins. Frontiers In Endocrinology 2010, 1: 12. PMID: 22654789, PMCID: PMC3356007, DOI: 10.3389/fendo.2010.00012.
- So A, Bernal T, Pillsbury M, Yamamoto K, Feldman B. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17582-17587. PMID: 19805059, PMCID: PMC2757402, DOI: 10.1073/pnas.0909733106.
- Kocan M, See H, Sampaio N, Eidne K, Feldman B, Pfleger K. Agonist-Independent Interactions between β-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis. The Journal Of Clinical Endocrinology & Metabolism 2009, 94: 1475-1475. DOI: 10.1210/jcem.94.4.9993.
- Feldman B. Glucocorticoids Influence on Mesenchymal Stem Cells and Implications for Metabolic Disease. Pediatric Research 2009, 65: 249-251. PMID: 19262295, PMCID: PMC2716735, DOI: 10.1203/pdr.0b013e3181909c08.
- Kocan M, See H, Sampaio N, Eidne K, Feldman B, Pfleger K. Agonist-Independent Interactions between β-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis. Endocrinology 2009, 23: 559-571. PMID: 19179480, PMCID: PMC2667710, DOI: 10.1210/me.2008-0321.
- So A, Cooper S, Feldman B, Manuchehri M, Yamamoto K. Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 5745-5749. PMID: 18408151, PMCID: PMC2311370, DOI: 10.1073/pnas.0801551105.
- Feldman B. Is Your Metabolism Determined By (Cell) Fate? Pediatric Research 2007, 61: 636-639. PMID: 17426662, DOI: 10.1203/pdr.0b013e31805d854e.
- Rosenthal S, Gitelman S, Vargas G, Feldman B. Gain-of-Function Mutations in the V2 Vasopressin Receptor. Hormone Research In Paediatrics 2007, 67: 121-125. DOI: 10.1159/000097567.
- Bremer A, Feldman B, Iezza G, Clark O, Rosenthal S. Report of a Hürthle Cell Neoplasm in a Peripubertal Girl. Thyroid 2007, 17: 175-178. PMID: 17316121, DOI: 10.1089/thy.2006.0214.
- Fortescue E, Shin A, Greenes D, Mannix R, Agarwal S, Feldman B, Shah M, Rifai N, Landzberg M, Newburger J, Almond C. Cardiac Troponin Increases Among Runners in the Boston Marathon. Annals Of Emergency Medicine 2006, 49: 137-143.e1. PMID: 17145114, DOI: 10.1016/j.annemergmed.2006.09.024.
- Rosenthal S, Feldman B, Vargas G, Gitelman S. Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatric Endocrinology Reviews : PER 2006, 4 Suppl 1: 66-70. PMID: 17261972.
- Feldman B, Streeper R, Farese R, Yamamoto K. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 15675-15680. PMID: 17030820, PMCID: PMC1592529, DOI: 10.1073/pnas.0607501103.
- Gitelman S, Feldman B, Rosenthal S. Nephrogenic Syndrome of Inappropriate Antidiuresis: A Novel Disorder in Water Balance in Pediatric Patients. The American Journal Of Medicine 2006, 119: s54-s58. PMID: 16843086, DOI: 10.1016/j.amjmed.2006.05.008.
- Huang E, Feldman B, Schwartz I, Geller D, Rosenthal S, Gitelman S. Oral Urea for the Treatment of Chronic Syndrome of Inappropriate Antidiuresis in Children. The Journal Of Pediatrics 2006, 148: 128-131. PMID: 16423613, DOI: 10.1016/j.jpeds.2005.08.031.
- Feldman B, Rosenthal S, Vargas G, Fenwick R, Huang E, Matsuda-Abedini M, Lustig R, Mathias R, Portale A, Miller W, Gitelman S. Nephrogenic Syndrome of Inappropriate Antidiuresis. The New England Journal Of Medicine 2005, 352: 1884-1890. PMID: 15872203, PMCID: PMC5340184, DOI: 10.1056/nejmoa042743.
- Feldman B, Rosenthal D. Carbohydrate-Deficient Glycoprotein Syndrome-Associated Pericardial Effusion Treated with Corticosteroids and Salicylic Acid. Pediatric Cardiology 2002, 23: 469-471. PMID: 12170369, DOI: 10.1007/s00246-002-1497-1.
- Feldman B, Feldman D. The development of androgen-independent prostate cancer. Nature Reviews Cancer 2001, 1: 34-45. PMID: 11900250, DOI: 10.1038/35094009.
- Feldman B, Hampton T, Cleary M. A carboxy-terminal deletion mutant of Notch1accelerates lymphoid oncogenesis in E2A-PBX1transgenic mice. Blood 2000, 96: 1906-1913. DOI: 10.1182/blood.v96.5.1906.
- Feldman B, Hampton T, Cleary M. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood 2000, 96: 1906-13. PMID: 10961893, DOI: 10.1182/blood.v96.5.1906.h8001906_1906_1913.
- Feldman B, Reid T, Cleary M. Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice. Oncogene 1997, 15: 2735-2742. PMID: 9401000, DOI: 10.1038/sj.onc.1201670.
- LeBrun D, Matthews B, Feldman B, Cleary M. The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. Oncogene 1997, 15: 2059-2067. PMID: 9366523, DOI: 10.1038/sj.onc.1201367.
- Feldman B, D'Alessandro A, Osterloh J, Hata B. Electrochemical determination of low blood lead concentrations with a disposable carbon microarray electrode. Clinical Chemistry 1995, 41: 557-563. PMID: 7720246, DOI: 10.1093/clinchem/41.4.557.
- Fox M, Feldman B, Chu G. A Novel Role for DNA Photolyase: Binding to DNA Damaged by Drugs Is Associated with Enhanced Cytotoxicity in Saccharomyces cerevisiae. Molecular And Cellular Biology 1994, 14: 8071-8077. DOI: 10.1128/mcb.14.12.8071-8077.1994.
- Fox M, Feldman B, Chu G. A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae. Molecular And Cellular Biology 1994, 14: 8071-8077. PMID: 7969145, PMCID: PMC359345, DOI: 10.1128/mcb.14.12.8071.
- Feldman B, Osterloh J, Hata B, D'Alessandro A. Determination of lead in blood by square wave anodic stripping voltammetry at a carbon disk ultramicroelectrode. Analytical Chemistry 1994, 66: 1983-7. PMID: 8067521, DOI: 10.1021/ac00085a010.
- Osterloh J, Feldman B. Urinary Protein Markers in Pesticide Applicators During a Chlorinated Hydrocarbon Exposure. Environmental Research 1993, 63: 171-181. PMID: 8243412, DOI: 10.1006/enrs.1993.1138.
- Feldman B, Mogadeddi H, Osterloh J. Determination of Pb2+ in water by isotope dilution gas chromatography-mass spectrometry of tetraethyllead formed by reaction with sodium tetraethylborate. Journal Of Chromatography A 1992, 594: 275-282. DOI: 10.1016/0021-9673(92)80340-z.
Departments and Programs
Locations
1
1 of 2
- Yale Pediatric Endocrinology1 Long Wharf DriveSte 503New Haven, CT 06511
- Yale Pediatric EndocrinologyGreenwich Hospital5 Perryridge RdGreenwich, CT 06830
1
1 of 2
- Yale Pediatric Endocrinology1 Long Wharf DriveSte 503New Haven, CT 06511
- Yale Pediatric EndocrinologyGreenwich Hospital5 Perryridge RdGreenwich, CT 06830