Adam Mecca, MD, PhD
Biography
Adam Mecca, MD, PhD is a geriatric psychiatrist who specializes in memory disorders including Alzheimer’s disease, dementia, mild cognitive impairment, and other related conditions.
“I enjoy meeting patients and their families and working together to understand the cause of a person's symptoms and finding the best way to help,” Dr. Mecca says. “I value the opportunity to work with patients experiencing changes in their memory and thinking. We discuss the important changes occurring in their life, and work on building supports so that they can continue to thrive in all ways possible.”
An active researcher, Dr. Mecca studies Alzheimer’s disease and related disorders. “It is a very satisfying focus since memory disorders affect so many people. There is an enormous need for effective treatments,” he says. “I am passionate about bringing understanding of a life-altering disease process into awareness. It is vital to educate, provide treatment, and to help patients and families work through what is often a progressive and incurable illness.”
As the associate director of the Yale Alzheimer’s Disease Research Unit, he works with a team to better understand Alzheimer’s disease and develop effective therapies. He and his collaborators are creating neuroimaging methods to investigate the neurobiology of Alzheimer’s disease.
Their efforts have led to a novel positron emission tomography (PET) imaging technique to measure decreases in the number of connections between nerve cells in people with Alzheimer’s disease. This work may accelerate the development of effective treatments.
Titles
- Assistant Professor of Psychiatry
- Associate Director, Alzheimer's Disease Research Unit
- Faculty, Alzheimer's Disease Research Center (ADRC)
Education & Training
- FellowYale University (2017)
- ResidentYale University (2016)
- PhDUniversity of Florida College of Medicine, Physiology and Pharmacology, Dept of Physiology and Functional Genomics (2012)
- MDUniversity of Florida College of Medicine (2012)
- BSUniversity of Florida, Chemistry and Microbiology (2005)
Additional Information
- O'Dell R, Mecca A, Waszak J, Sharp E, Chen M, Naganawa M, Toyonaga T, Lu Y, Chupak A, Cooper E, Lam J, Miller A, Waldner E, Weibley H, Zhao Y, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C. Association of synaptic density and glucose metabolism with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB‐J and [18F]FDG Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.062595.
- Salardini E, Silva‐Rudberg J, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of gray matter microstructure and synaptic density in Alzheimer's Disease: a multimodal imaging study with DWI and SV2A PET Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.065162.
- Salardini E, Silva‐Rudberg J, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of gray matter microstructure and synaptic density in Alzheimer’s Disease: a multimodal imaging study with DWI and SV2A PET Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.065064.
- Pandey K, Waybright L, Duong D, Malagise E, Blennow K, Zetterberg H, Mecca A, van Dyck C, Caggiano A, Seyfried N, Hamby M. CSF proteomics analysis to investigate the pharmacodynamic response of the S2R modulator CT1812 in Alzheimer’s disease patients from the SPARC clinical trial Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.068166.
- Young J, Park H, Par‐Young J, Bartlett H, Kim H, Shin M, You S, Kim M, Allore H, Mecca A, Kang I. Investigating a CD8+ T cell age‐associated gene signature in Alzheimer's disease Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.064384.
- Kelly K, O'Dell R, Toyonaga T, Barcelos N, Gelernter J, Varma P, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. P95. Cortical Amyloid Burden is Associated With Basal Forebrain but Not Medial Temporal Lobe Atrophy in Adults at Varying APOE ɛ4 Risk for Alzheimer’s Disease Biological Psychiatry 2022, 91: s125-s126. DOI: 10.1016/j.biopsych.2022.02.329.
- Kelly K, Toyonaga T, Zhao W, Barcelos N, Gelernter J, Varma P, Nabulsi N, Wyk B, Huang Y, Carson R, van Dyck C, Mecca A. The relationship between cortical amyloid burden and basal forebrain volume in adults at varying APOE ?4 risk for Alzheimer's disease American Journal Of Geriatric Psychiatry 2022, 30: s25. DOI: 10.1016/j.jagp.2022.01.301.
- Silva-Rudberg J, Salardini E, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of gray matter microstructure and synaptic density in Alzheimer's disease: A multimodal imaging study with DWI and SV2A PET American Journal Of Geriatric Psychiatry 2022, 30: s26. DOI: 10.1016/j.jagp.2022.01.303.
- O'Dell R, van Dyck C, Mecca A. All that's Amnestic Isn't Alzheimer's: a Clinical Case Report of an Alzheimer's disease-like Amnestic Syndrome with Incongruent Biomarkers American Journal Of Geriatric Psychiatry 2022, 30: s24. DOI: 10.1016/j.jagp.2022.01.295.
- Mecca A, Ashton N, Chen M, O'Dell R, Naganawa M, Toyonaga T, Zhao W, Nabulsi N, Brinkmalm A, Kvartsberg H, Schöll M, Arnsten A, Huang Y, Blennow K, Zetterberg H, Carson R, van Dyck C, Nilsson J. Cerebrospinal fluid and brain PET measures of synaptic density glycoprotein 2A: Biomarkers of synaptic density in Alzheimer’s disease Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.054831.
- van Dyck C, Sharp E, O'Dell R, Banks E, Bartlett H, Chen M, Naganawa M, Toyonaga T, Harris J, Ni G, Zhao W, Nabulsi N, Wyk B, Huang Y, Arnsten A, Carson R, Mecca A. Synaptic density is associated with cognitive performance in Alzheimer’s disease: A PET imaging study with [11C]UCB‐J Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.054213.
- Datta D, Leslie SN, Woo E, Amancharla N, Elmansy A, Lepe M, Mecca AP, Slusher BS, Nairn AC, Arnsten AFT. Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance Frontiers In Aging Neuroscience 2021, 13: 760270. PMID: 34867287, PMCID: PMC8634091, DOI: 10.3389/fnagi.2021.760270.
- Zhou B, Wang R, Chen M, Mecca A, O’Dell R, Van Dyck C, Carson R, Duncan J, Liu C. Synthesizing Multi-tracer PET Images for Alzheimer’s Disease Patients Using a 3D Unified Anatomy-Aware Cyclic Adversarial Network 2021, 12906: 34-43. DOI: 10.1007/978-3-030-87231-1_4.
- Wang R, Liu H, Toyonaga T, Shi L, Wu J, Onofrey JA, Tsai Y, Naganawa M, Ma T, Liu Y, Chen M, Mecca AP, O’Dell R, Dyck C, Carson RE, Liu C. Generation of synthetic PET images of synaptic density and amyloid from 18F‐FDG images using deep learning Medical Physics 2021, 48: 5115-5129. PMID: 34224153, PMCID: PMC8455448, DOI: 10.1002/mp.15073.
- Lu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.
- Mecca AP, Rogers K, Jacobs Z, McDonald JW, Michalak HR, DellaGioia N, Zhao W, Hillmer AT, Nabulsi N, Lim K, Ropchan J, Huang Y, Matuskey D, Esterlis I, Carson RE, van Dyck CH. Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET NeuroImage 2021, 238: 118217. PMID: 34052464, PMCID: PMC8378132, DOI: 10.1016/j.neuroimage.2021.118217.
- Fang XT, Toyonaga T, Hillmer AT, Matuskey D, Holmes SE, Radhakrishnan R, Mecca AP, van Dyck CH, D’Souza D, Esterlis I, Worhunsky PD, Carson RE. Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis NeuroImage 2021, 237: 118167. PMID: 34000404, PMCID: PMC8452380, DOI: 10.1016/j.neuroimage.2021.118167.
- O'Dell R, Mecca A, Sharp E, Banks E, Bartlett H, Chen M, Naganawa M, Toyonaga T, Harris J, Ni G, Zhao W, Nabulsi N, Wyk B, Huang Y, Carson R, Arnsten A, van Dyck C. Synaptic Loss is Associated With Cognitive Impairment in Early Alzheimer’s Disease: A PET Imaging Study With [11C]UCB-J Biological Psychiatry 2021, 89: s107-s108. DOI: 10.1016/j.biopsych.2021.02.276.
- Pathak GA, Wendt FR, Levey DF, Mecca AP, van Dyck CH, Gelernter J, Polimanti R. Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression. Human Molecular Genetics 2021, 30: 1360-1370. PMID: 33831179, PMCID: PMC8255129, DOI: 10.1093/hmg/ddab102.
- van Dyck CH, O'Dell RS, Mecca AP. Amyloid-Associated Depression—or Not? Biological Psychiatry 2021, 89: 737-738. PMID: 33766236, PMCID: PMC8396710, DOI: 10.1016/j.biopsych.2021.02.008.
- O'Dell R, Mecca A, Chen M, Naganawa M, Toyonaga T, Lu Y, Godek T, Harris J, Bartlett H, Banks E, Kominek V, Zhao W, Nabulsi N, Ropchan J, Ye Y, Wyk B, Huang Y, Arnsten A, Carson R, van Dyck C. Association of Aß deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [11C]UCB-J American Journal Of Geriatric Psychiatry 2021, 29: s37-s40. DOI: 10.1016/j.jagp.2021.01.034.
- Sharp E, O'Dell R, Banks E, Bartlett H, Chen M, Naganawa M, Toyonaga T, Harris J, Ni G, Zhao W, Nabulsi N, Wyk B, Huang Y, Arnsten A, Carson R, Mecca A, van Dyck C. Synaptic density is associated with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB-J American Journal Of Geriatric Psychiatry 2021, 29: s119-s120. DOI: 10.1016/j.jagp.2021.01.114.
- Principal component analysis of synaptic density measured with [11C]UCB-J PET in Alzheimer's diseaseO'Dell R, Higgins-Chen A, Gupta D, Chen M, Naganawa M, Toyonaga T, Lu Y, Banks E, Bartlett H, Harris J, Zhao W, Nabulsi N, Wyk B, Huang Y, Arnsten A, Carson R, van Dyck C, Mecca A. Principal component analysis of synaptic density measured with [11C]UCB-J PET in Alzheimer's disease American Journal Of Geriatric Psychiatry 2021, 29: s47-s48. DOI: 10.1016/j.jagp.2021.01.041.
- Fahed M, Lane C, Khasnavis S, Mecca A. Recipes for Adult Learning: Innovations in teaching neuroimaging to geriatric trainees American Journal Of Geriatric Psychiatry 2021, 29: s16-s17. DOI: 10.1016/j.jagp.2021.02.022.
- Donovan N, Mecca A, Smith G, Gatchel J. Molecular Imaging in Alzheimer's Disease: Linking pathologic, neurotransmitter, synaptic and clinical findings relevant to geriatric psychiatry American Journal Of Geriatric Psychiatry 2021, 29: s8. DOI: 10.1016/j.jagp.2021.02.004.
- Gatchel J, Mecca A, Padala P. Developing Your Reseach Career American Journal Of Geriatric Psychiatry 2021, 29: s13-s14. DOI: 10.1016/j.jagp.2021.02.016.
- Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O’Dell R, McDonald JW, Michalak HR, Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study Cerebrovascular And Brain Metabolism Reviews 2021, 41: 2395-2409. PMID: 33757318, PMCID: PMC8393289, DOI: 10.1177/0271678x211004312.
- O’Dell R, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J Alzheimer's Research & Therapy 2021, 13: 11. PMID: 33402201, PMCID: PMC7786921, DOI: 10.1186/s13195-020-00742-y.
- Salardini A, Hillmer A, Mecca A, Hashemi‐Aghdam A, Laltoo E, Savoia S, O'Dell R, Harris J, Godek T, Nabulsi N, Lim K, Ropchan J, Huang Y, Cosgrove K, Carson R, Strittmatter S, van Dyck C. PBR28 Brain PET imaging with lipopolysaccharide challenge for the study of microglia function in Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.037792.
- Mecca A, Ashton N, Chen M, O'Dell R, Naganawa M, Toyonaga T, Harris J, Bartlett H, Banks E, Kominek V, Nabulsi N, Najafzadeh S, Wyk B, Brinkmalm A, Kvartsberg H, Schöll M, Arnsten A, Huang Y, Blennow K, Zetterberg H, Carson R, van Dyck C. Association between cerebrospinal fluid biomarkers of neurodegeneration and PET measurements of synaptic density in Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.044211.
- Salardini A, Hillmer A, Mecca A, Hashemi‐Aghdam A, Laltoo E, Savoia S, O'Dell R, Harris J, Godek T, Nabulsi N, Lim K, Ropchan J, Huang Y, Cosgrove K, Carson R, Strittmatter S, van Dyck C. 11C‐PBR28 brain PET imaging with lipopolysaccharide challenge for the study of microglia function in Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043584.
- O'Dell R, Mecca A, Chen M, Godek T, Harris J, Bartlett H, Banks E, Kominek V, Zhao W, Naganawa M, Toyonaga T, Lu Y, Nabulsi N, Ropchan J, Ye Y, Wyk B, Varma P, Arnsten A, Huang Y, Carson R, van Dyck C. Association between cerebral amyloid accumulation and synaptic density in Alzheimer’s disease: A multitracer PET study Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043631.
- Fang X, Mecca A, Naganawa M, O'Dell R, Chen M, van Dyck C, Carson R. ICA‐derived sources of synaptic density PET ([11C]UCB‐J) relate to cognitive impairment severity in Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.041197.
- Mecca A, O'Dell R, Chen M, Naganawa M, Toyonaga T, Godek T, Harris J, Bartlett H, Zhao W, Gallezot J, Nabulsi N, Ropchan J, Ye Y, Wyk B, Arnsten A, Huang Y, Carson R, van Dyck C. In vivo measurement of widespread synaptic loss and associated tau accumulation in early Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.037791.
- O'Dell R, Naganawa M, Toyonaga T, Young J, Dahal R, Singh E, Waheed A, Banks E, Harris J, Chen M, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Validation of a simplified tissue‐to‐reference ratio measurement using SUVR for the assessment of synaptic density alterations in Alzheimer’s disease using [11C]UCB‐J PET Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.045928.
- Mecca AP, Dyck C. Alzheimer's & Dementia: The Journal of the Alzheimer's Association Alzheimer's & Dementia 2020, 17: 316-317. PMID: 33047474, PMCID: PMC7962853, DOI: 10.1002/alz.12190.
- Naganawa M, Gallezot JD, Finnema SJ, Matuskey D, Mecca A, Nabulsi NB, Labaree D, Ropchan J, Malison RT, D'Souza DC, Esterlis I, Detyniecki K, van Dyck CH, Huang Y, Carson RE. Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort Journal Of Nuclear Medicine 2020, 62: 418-421. PMID: 32646875, PMCID: PMC8049341, DOI: 10.2967/jnumed.120.243949.
- Mecca AP, Chen M, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Nabulsi NB, Wyk BCV, Varma P, Arnsten AFT, Huang Y, Carson RE, Dyck C. In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET Alzheimer's & Dementia 2020, 16: 974-982. PMID: 32400950, PMCID: PMC7383876, DOI: 10.1002/alz.12097.
- Krystal HL, Ross DA, Mecca AP. Amyloid: From Starch to Finish Biological Psychiatry 2020, 87: e23-e24. PMID: 32299582, PMCID: PMC7449531, DOI: 10.1016/j.biopsych.2020.02.1182.
- O'Dell R, Mecca A, Chen M, Godek T, Harris J, Bartlett H, Zhao W, Naganawa M, Toyonaga T, Lu Y, Nabulsi N, Wyk B, Varma P, Arnsten A, Huang Y, Carson R, van Dyck C. ASSOCIATION BETWEEN CEREBRAL AMYLOID ACCUMULATION AND SYNAPTIC DENSITY IN ALZHEIMER'S DISEASE: A MULTITRACER PET STUDY American Journal Of Geriatric Psychiatry 2020, 28: s123-s124. DOI: 10.1016/j.jagp.2020.01.153.
- Fahed M, Lane C, Khasnavis S, Mecca A. Session 401 American Journal Of Geriatric Psychiatry 2020, 28: s38-s39. DOI: 10.1016/j.jagp.2020.01.070.
- Donovan N, Mecca A, Smith G, Gatchel J. Session 102 American Journal Of Geriatric Psychiatry 2020, 28: s4. DOI: 10.1016/j.jagp.2020.01.017.
- Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. PET imaging of mGluR5 in Alzheimer’s disease Alzheimer's Research & Therapy 2020, 12: 15. PMID: 31954399, PMCID: PMC6969979, DOI: 10.1186/s13195-020-0582-0.
- Kemp EC, Ebner MK, Ramanan S, Godek TA, Pugh EA, Bartlett HH, McDonald JW, Mecca MC, van Dyck CH, Mecca AP, Initiative T. Statin Use and Risk of Cognitive Decline in the ADNI Cohort American Journal Of Geriatric Psychiatry 2019, 28: 507-517. PMID: 31806426, PMCID: PMC7170771, DOI: 10.1016/j.jagp.2019.11.003.
- Mecca A, Chen M, Naganawa M, Toyonaga T, Godek T, Harris J, Bartlett H, Gallezot J, Charil A, Nabulsi N, Huang Y, Arnsten A, Carson R, Dyck C. P4‐481: ASSOCIATION BETWEEN ENTORHINAL CORTICAL TAU ACCUMULATION AND HIPPOCAMPAL SYNAPTIC DENSITY IN OLDER INDIVIDUALS WITH NORMAL COGNITION AND EARLY ALZHEIMER'S DISEASE: PRELIMINARY EXPERIENCE Alzheimer's & Dementia 2019, 15: p1497-p1497. DOI: 10.1016/j.jalz.2019.08.027.
- Mecca A, Chen M, Godek T, Harris J, Bartlett H, Toyonaga T, Naganawa M, Salardini A, Arnsten A, Nabulsi N, Lim K, Najafzadeh S, Ropchan J, Huang Y, Carson R, Strittmatter S, Dyck C. IC‐P‐140: ASSOCIATION BETWEEN MGLUR5 AND SYNAPTIC DENSITY: A MULTI‐TRACER STUDY IN HEALTHY AGING AND ALZHEIMER'S DISEASE Alzheimer's & Dementia 2019, 15: p115-p115. DOI: 10.1016/j.jalz.2019.06.4254.
- Mecca A, Chen M, Godek T, Harris J, Bartlett H, Toyonaga T, Naganawa M, Salardini A, Arnsten A, Nabulsi N, Lim K, Najafzadeh S, Ropchan J, Huang Y, Carson R, Strittmatter S, Dyck C. P2‐349: ASSOCIATION BETWEEN MGLUR5 AND SYNAPTIC DENSITY: A MULTI‐TRACER STUDY OF HEALTHY AGING AND ALZHEIMER'S DISEASE Alzheimer's & Dementia 2019, 15: p729-p729. DOI: 10.1016/j.jalz.2019.06.2756.
- Thomas JM, Mecca MC, Niehoff KM, Mecca AP, Van Ness PH, Brienza R, Hyson A, Jeffery S. Development and Validation of a Polypharmacy Knowledge Assessment Instrument. American Journal Of Pharmaceutical Education 2019, 83: 6435. PMID: 31333246, PMCID: PMC6630871, DOI: 10.5688/ajpe6435.
- Mecca AP. 1ciii AD molecular: Molecular imaging of Alzheimer's disease: PET imaging of neurotransmitter systems 2019, 165: 139-165. PMID: 31481161, DOI: 10.1016/bs.pmbts.2019.04.003.
- Mecca MC, Thomas JM, Niehoff KM, Hyson A, Jeffery SM, Sellinger J, Mecca AP, Van Ness PH, Fried TR, Brienza R. Assessing an Interprofessional Polypharmacy and Deprescribing Educational Intervention for Primary Care Post-graduate Trainees: a Quantitative and Qualitative Evaluation Journal Of General Internal Medicine 2019, 34: 1220-1227. PMID: 30972554, PMCID: PMC6614292, DOI: 10.1007/s11606-019-04932-9.
- Gupta M, O'Dell R, Gelernter J, Carson R, van Dyck C, Mecca A. ASSOCIATION BETWEEN ODOR IDENTIFICATION AND REGIONAL GRAY MATTER IN EARLY PRECLINICAL ALZHEIMER'S DISEASE American Journal Of Geriatric Psychiatry 2019, 27: s143-s144. DOI: 10.1016/j.jagp.2019.01.098.
- O'Dell R, Gupta M, Gelernter J, Carson R, van Dyck C, Mecca A. REGION-SPECIFIC ATROPHY AS MEASURED BY CORTICAL GRAY MATTER VOLUME IS ASSOCIATED WITH BOTH REGIONAL AND TOTAL CORTICAL AMYLOID-BETA BURDEN IN COGNITIVELY NORMAL INDIVIDUALS AT RISK FOR ALZHEIMER'S DISEASE American Journal Of Geriatric Psychiatry 2019, 27: s145-s146. DOI: 10.1016/j.jagp.2019.01.100.
- Mecca A, Smith G, Gatchel J, Donovan J. ADVANCES IN THE MOLECULAR IMAGING OF ALZHEIMER'S DISEASE: NEUROBIOLOGICAL MECHANISMS OF DISEASE AND NEUROPSYCHIATRIC SYMPTOMS Session 209 American Journal Of Geriatric Psychiatry 2019, 27: s17-s18. DOI: 10.1016/j.jagp.2019.01.158.
- Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging JAMA Neurology 2018, 75: 1215-1224. PMID: 30014145, PMCID: PMC6233853, DOI: 10.1001/jamaneurol.2018.1836.
- Pugh EA, Kemp EC, van Dyck CH, Mecca AP, Sharp ES, Initiative F. Effects of Normative Adjustments to the Montreal Cognitive Assessment American Journal Of Geriatric Psychiatry 2018, 26: 1258-1267. PMID: 30314940, PMCID: PMC6779033, DOI: 10.1016/j.jagp.2018.09.009.
- Mecca A, McDonald J, Michalak H, Godek T, Harris J, Chen M, Nabulsi N, Salardini A, Carson R, Strittmatter S, Dyck C. P1‐469: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASE Alzheimer's & Dementia 2018, 14: p501-p503. DOI: 10.1016/j.jalz.2018.06.479.
- Chen M, Mecca A, Naganawa M, Finnema S, Toyonaga T, Gallezot J, McDonald J, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, Dyck C. P2‐365: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCE Alzheimer's & Dementia 2018, 14: p832-p832. DOI: 10.1016/j.jalz.2018.06.1056.
- Mecca A, Chen M, Naganawa M, Finnema S, Toyonaga T, Lin S, Gallezot J, McDonald J, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, Dyck C. IC‐P‐183: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCE Alzheimer's & Dementia 2018, 14: p152-p153. DOI: 10.1016/j.jalz.2018.06.2250.
- Mecca A, McDonald J, Michalak H, Godek T, Harris J, Chen M, Nabulsi N, Salardini A, Carson R, Strittmatter S, Dyck C. IC‐04‐03: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASE Alzheimer's & Dementia 2018, 14: p8-p9. DOI: 10.1016/j.jalz.2018.06.2051.
- Mecca AP, Michalak HR, McDonald JW, Kemp EC, Pugh EA, Becker ML, Mecca MC, van Dyck CH. Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort Dementia And Geriatric Cognitive Disorders 2018, 45: 232-242. PMID: 29886490, PMCID: PMC6178799, DOI: 10.1159/000488671.
- Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial Neurobiology Of Aging 2018, 70: 117-124. PMID: 30007160, PMCID: PMC6503670, DOI: 10.1016/j.neurobiolaging.2018.05.033.
- Regenhardt RW, Mecca AP, Flavin SA, Boulouis G, Lauer A, Zachrison KS, Boomhower J, Patel AB, Hirsch JA, Schwamm LH, Leslie-Mazwi TM. Delays in the Air or Ground Transfer of Patients for Endovascular Thrombectomy Stroke 2018, 49: 1419-1425. PMID: 29712881, PMCID: PMC5970980, DOI: 10.1161/strokeaha.118.020618.
- Mecca A, Chen M, Naganawa M, Finnema S, Toyonaga T, Lin S, McDonald J, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C. Poster Number: NR 14 Initial Experience with PET Imaging of Synaptic Density (SV2A) in Alzheimer's Disease: A New Biomarker for Clinical Trials? American Journal Of Geriatric Psychiatry 2018, 26: s145-s146. DOI: 10.1016/j.jagp.2018.01.176.
- Mecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, Nadelmann J, Benincasa AL, Ropchan J, Huang Y, Gelernter J, Van Ness PH, Carson RE, van Dyck CH. Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease Neurobiology Of Aging 2017, 61: 207-214. PMID: 29111487, PMCID: PMC5722236, DOI: 10.1016/j.neurobiolaging.2017.09.027.
- Mecca A, Rogers K, Jacobs Z, McDonald J, Michalak H, DellaGioia N, Nabulsi N, Matuskey D, Esterlis I, Carson R, van Dyck C. Poster Number: EI 39 Investigating Age Related Associations of Metabotropic Glutamate Receptor 5 Density Using [18F]FPEB and PET American Journal Of Geriatric Psychiatry 2017, 25: s96-s97. DOI: 10.1016/j.jagp.2017.01.110.
- Hassell C, Mecca M, Mecca A. Poster Number: EI 40 Characteristics of Older Adults with Homelessness or Housing Instability American Journal Of Geriatric Psychiatry 2017, 25: s97-s99. DOI: 10.1016/j.jagp.2017.01.119.
- DeWorsop D, Mecca M, Maiaroto M, Rodriguez-Guzman J, Hassell C, Mecca A, Iheanacho T. Poster Number: EI 11 Screening PRogram to Identify Needs Due to Geriatric Syndromes (SPRING): A New Perspective on Healthcare for Homeless Adults American Journal Of Geriatric Psychiatry 2016, 24: s77-s79. DOI: 10.1016/j.jagp.2016.01.076.
- Hassell C, Mecca M, DeWorsop D, Rodriguez-Guzman J, Maiaroto M, Iheanacho T, Mecca A. Poster Number: EI 51 Characterizing Trajectories of Homelessness in Older Adults American Journal Of Geriatric Psychiatry 2016, 24: s116-s118. DOI: 10.1016/j.jagp.2016.01.116.
- Rodriguez-Guzman J, Maiaroto M, DeWorsop D, Hassell C, Iheanacho T, Mecca A, Mecca M. Poster Number: EI 10 Utilizing a Direct Assessment to Identify Functional Impairments in Homeless Adults American Journal Of Geriatric Psychiatry 2016, 24: s76-s77. DOI: 10.1016/j.jagp.2016.01.075.
- Dyck C, Mecca A, Wang S, Barcelos N, Planeta-Wilson B, Gelernter J, Ness P, Carson R. P3‐143: Amyloid burden is associated with decreased gray matter volume but not episodic memory performance in cognitively normal first‐degree relatives at varying ApoE4 risk for Alzheimer's disease Alzheimer's & Dementia 2015, 11: p680-p681. DOI: 10.1016/j.jalz.2015.06.1011.
- Dyck C, Mecca A, Wang S, Barcelos N, Planeta-Wilson B, Gelernter J, Ness P, Carson R. IC‐P‐101: Amyloid burden is associated with decreased gray matter volume but not episodic memory performance in cognitively normal first‐degree relatives at varying ApoE4 risk for Alzheimer's disease Alzheimer's & Dementia 2015, 11: p69-p69. DOI: 10.1016/j.jalz.2015.06.123.
- Bennion D, Regenhardt R, Mecca A, Sumners C. Chapter 28 Mas and Neuroprotection in Stroke 2015, 201-205. DOI: 10.1016/b978-0-12-801364-9.00028-6.
- Fineberg SK, Mecca A, Lerner BA, Hills OF, Corlett PR, Viron M. Idiom Use in a Young Man with Schizophrenia and Prominent Sexual Delusions Harvard Review Of Psychiatry 2014, 22: 306-315. PMID: 25188734, DOI: 10.1097/hrp.0000000000000053.
- Joseph JP, Mecca AP, Regenhardt RW, Bennion DM, Rodríguez V, Desland F, Patel NA, Pioquinto DJ, Unger T, Katovich MJ, Steckelings UM, Sumners C. The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke Neuropharmacology 2014, 81: 134-141. PMID: 24508710, PMCID: PMC7472595, DOI: 10.1016/j.neuropharm.2014.01.044.
- Regenhardt RW, Mecca AP, Desland F, Ritucci‐Chinni P, Ludin JA, Greenstein D, Banuelos C, Bizon JL, Reinhard MK, Sumners C. Centrally administered angiotensin‐(1–7) increases the survival of stroke‐prone spontaneously hypertensive rats Experimental Physiology 2013, 99: 442-453. PMID: 24142453, PMCID: PMC7416533, DOI: 10.1113/expphysiol.2013.075242.
- Regenhardt RW, Desland F, Mecca AP, Pioquinto DJ, Afzal A, Mocco J, Sumners C. Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke Neuropharmacology 2013, 71: 154-163. PMID: 23583926, PMCID: PMC3664115, DOI: 10.1016/j.neuropharm.2013.03.025.
- Regenhardt RW, Ansari S, Azari H, Caldwell KJ, Mecca AP. Utilizing a cranial window to visualize the middle cerebral artery during endothelin-1 induced middle cerebral artery occlusion. Journal Of Visualized Experiments 2013, e50015. PMID: 23463164, PMCID: PMC3605805, DOI: 10.3791/50015.
- Regenhardt R, Ansari S, Azari H, Caldwell K, Mecca A. Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion Journal Of Visualized Experiments 2013 DOI: 10.3791/50015-v.
- Ansari S, Azari H, Caldwell KJ, Regenhardt RW, Hedna VS, Waters MF, Hoh BL, Mecca AP. Endothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat. Journal Of Visualized Experiments 2013 PMID: 23438950, PMCID: PMC3601209, DOI: 10.3791/50014.
- Ansari S, Azari H, Caldwell K, Regenhardt R, Hedna V, Waters M, Hoh B, Mecca A. Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat Journal Of Visualized Experiments 2013 DOI: 10.3791/50014-v.
- Mecca AP, Regenhardt RW, O’Connor T, Joseph JP, Raizada MK, Katovich MJ, Sumners C. Cerebroprotection by angiotensin‐(1–7) in endothelin‐1‐induced ischaemic stroke Experimental Physiology 2011, 96: 1084-1096. PMID: 21685445, PMCID: PMC3210510, DOI: 10.1113/expphysiol.2011.058578.
- Regenhardt R, Ritucci‐Chinni P, Desland F, Mecca A, Sumners C. Angiotensin(1–7) increases survival of stroke‐prone spontaneously hypertensive rats The FASEB Journal 2011, 25: 650.10-650.10. DOI: 10.1096/fasebj.25.1_supplement.650.10.
- Joseph J, Regenhardt R, Mecca A, Patel N, Steckelings U, Unger T, Katovich M, Sumners C. Central and Peripheral Administration of Compound 21 Elicits Cerebroprotective Effects in Ischemic Stroke The FASEB Journal 2011, 25: lb576-lb576. DOI: 10.1096/fasebj.25.1_supplement.lb576.
- Cao W, Glushakov A, Shah HP, Mecca AP, Sumners C, Shi P, Seubert CN, Martynyuk AE. Halogenated aromatic amino acid 3,5-dibromo-d-tyrosine produces beneficial effects in experimental stroke and seizures Amino Acids 2010, 40: 1151-1158. PMID: 20839013, PMCID: PMC8396070, DOI: 10.1007/s00726-010-0739-4.
- Ferreira AJ, Santos RA, Bradford CN, Mecca AP, Sumners C, Katovich MJ, Raizada MK. Therapeutic Implications of the Vasoprotective Axis of the Renin-Angiotensin System in Cardiovascular Diseases Hypertension 2009, 55: 207-213. PMID: 20038757, PMCID: PMC2826213, DOI: 10.1161/hypertensionaha.109.140145.
- Cao W, Shah H, Glushakov A, Mecca A, Shi P, Sumners C, Seubert C, Martynyuk A. Efficacy of 3,5‐dibromo‐L‐phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit British Journal Of Pharmacology 2009, 158: 2005-2013. PMID: 20050189, PMCID: PMC2807662, DOI: 10.1111/j.1476-5381.2009.00498.x.
- Martynyuk A, Sumners C, Cao W, Shah H, Mecca A, Seubert C. FP19-TU-03 3,5-Dibromo-l-phenylalanine depresses pentylenetetrazole-induced seizures and reduces neurological and sensorimotor gating deficits caused by stroke Journal Of The Neurological Sciences 2009, 285: s87. DOI: 10.1016/s0022-510x(09)70364-8.
- Mecca AP, O'Connor TE, Katovich MJ, Sumners C. Candesartan pretreatment is cerebroprotective in a rat model of endothelin‐1‐induced middle cerebral artery occlusion Experimental Physiology 2009, 94: 937-946. PMID: 19429641, PMCID: PMC2742297, DOI: 10.1113/expphysiol.2009.047936.
- Mecca A, O'Connor T, Dooies K, Katovich M, Sumners C. Cerebroprotective action of angiotensin 1‐7 in a rat model of ischemic stroke The FASEB Journal 2009, 23: 947.1-947.1. DOI: 10.1096/fasebj.23.1_supplement.947.1.
- Shi P, Jiang N, Li H, Mecca A, Raizada M, Sumners C. Paraventricular nucleus (PVN) neurons projecting to the rostral ventrolateral medulla (RVLM) contain both oxytocin and glutamate The FASEB Journal 2009, 23: 967.6-967.6. DOI: 10.1096/fasebj.23.1_supplement.967.6.
- Overexpression of Angiotensin II type 2 receptor (AT2R) in neonatal cardiomyocytes induces apoptosisQi Y, Li H, Mecca A, Shenoy V, Sumners C, Katovich M. Overexpression of Angiotensin II type 2 receptor (AT2R) in neonatal cardiomyocytes induces apoptosis The FASEB Journal 2008, 22: 1238.18-1238.18. DOI: 10.1096/fasebj.22.1_supplement.1238.18.
- Grobe J, Mecca A, Lingis M, Shenoy V, Bolton T, Machado J, Speth R, Raizada M, Katovich M. Angiotensin‐(1–7) prevents cardiac remodeling during angiotensin II‐induced hypertension The FASEB Journal 2007, 21: a896-a897. DOI: 10.1096/fasebj.21.6.a896-d.
- Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1–7) AJP Heart And Circulatory Physiology 2006, 292: h736-h742. PMID: 17098828, DOI: 10.1152/ajpheart.00937.2006.
- Mitra A, Katovich MJ, Mecca A, Rowland NE. Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats Physiology & Behavior 2006, 89: 221-225. PMID: 16839572, DOI: 10.1016/j.physbeh.2006.06.006.
- Grobe J, Mecca A, Lingis M, Mao H, Katovich M. Angiotensin 1‐7 prevents cardiac fibrosis in angiotensin II and DOCA‐salt models of hypertension The FASEB Journal 2006, 20: a305-a306. DOI: 10.1096/fasebj.20.4.a305-d.
- Grobe JL, Mecca AP, Mao H, Katovich MJ. Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension AJP Heart And Circulatory Physiology 2006, 290: h2417-h2423. PMID: 16415071, DOI: 10.1152/ajpheart.01170.2005.
- Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. Protection from angiotensin II‐induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats Experimental Physiology 2005, 90: 783-790. PMID: 16049057, DOI: 10.1113/expphysiol.2005.031096.
Biography
Adam Mecca, MD, PhD is a geriatric psychiatrist who specializes in memory disorders including Alzheimer’s disease, dementia, mild cognitive impairment, and other related conditions.
“I enjoy meeting patients and their families and working together to understand the cause of a person's symptoms and finding the best way to help,” Dr. Mecca says. “I value the opportunity to work with patients experiencing changes in their memory and thinking. We discuss the important changes occurring in their life, and work on building supports so that they can continue to thrive in all ways possible.”
An active researcher, Dr. Mecca studies Alzheimer’s disease and related disorders. “It is a very satisfying focus since memory disorders affect so many people. There is an enormous need for effective treatments,” he says. “I am passionate about bringing understanding of a life-altering disease process into awareness. It is vital to educate, provide treatment, and to help patients and families work through what is often a progressive and incurable illness.”
As the associate director of the Yale Alzheimer’s Disease Research Unit, he works with a team to better understand Alzheimer’s disease and develop effective therapies. He and his collaborators are creating neuroimaging methods to investigate the neurobiology of Alzheimer’s disease.
Their efforts have led to a novel positron emission tomography (PET) imaging technique to measure decreases in the number of connections between nerve cells in people with Alzheimer’s disease. This work may accelerate the development of effective treatments.
Titles
- Assistant Professor of Psychiatry
- Associate Director, Alzheimer's Disease Research Unit
- Faculty, Alzheimer's Disease Research Center (ADRC)
Education & Training
- FellowYale University (2017)
- ResidentYale University (2016)
- PhDUniversity of Florida College of Medicine, Physiology and Pharmacology, Dept of Physiology and Functional Genomics (2012)
- MDUniversity of Florida College of Medicine (2012)
- BSUniversity of Florida, Chemistry and Microbiology (2005)
Additional Information
- O'Dell R, Mecca A, Waszak J, Sharp E, Chen M, Naganawa M, Toyonaga T, Lu Y, Chupak A, Cooper E, Lam J, Miller A, Waldner E, Weibley H, Zhao Y, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C. Association of synaptic density and glucose metabolism with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB‐J and [18F]FDG Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.062595.
- Salardini E, Silva‐Rudberg J, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of gray matter microstructure and synaptic density in Alzheimer's Disease: a multimodal imaging study with DWI and SV2A PET Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.065162.
- Salardini E, Silva‐Rudberg J, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of gray matter microstructure and synaptic density in Alzheimer’s Disease: a multimodal imaging study with DWI and SV2A PET Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.065064.
- Pandey K, Waybright L, Duong D, Malagise E, Blennow K, Zetterberg H, Mecca A, van Dyck C, Caggiano A, Seyfried N, Hamby M. CSF proteomics analysis to investigate the pharmacodynamic response of the S2R modulator CT1812 in Alzheimer’s disease patients from the SPARC clinical trial Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.068166.
- Young J, Park H, Par‐Young J, Bartlett H, Kim H, Shin M, You S, Kim M, Allore H, Mecca A, Kang I. Investigating a CD8+ T cell age‐associated gene signature in Alzheimer's disease Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.064384.
- Kelly K, O'Dell R, Toyonaga T, Barcelos N, Gelernter J, Varma P, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. P95. Cortical Amyloid Burden is Associated With Basal Forebrain but Not Medial Temporal Lobe Atrophy in Adults at Varying APOE ɛ4 Risk for Alzheimer’s Disease Biological Psychiatry 2022, 91: s125-s126. DOI: 10.1016/j.biopsych.2022.02.329.
- Kelly K, Toyonaga T, Zhao W, Barcelos N, Gelernter J, Varma P, Nabulsi N, Wyk B, Huang Y, Carson R, van Dyck C, Mecca A. The relationship between cortical amyloid burden and basal forebrain volume in adults at varying APOE ?4 risk for Alzheimer's disease American Journal Of Geriatric Psychiatry 2022, 30: s25. DOI: 10.1016/j.jagp.2022.01.301.
- Silva-Rudberg J, Salardini E, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of gray matter microstructure and synaptic density in Alzheimer's disease: A multimodal imaging study with DWI and SV2A PET American Journal Of Geriatric Psychiatry 2022, 30: s26. DOI: 10.1016/j.jagp.2022.01.303.
- O'Dell R, van Dyck C, Mecca A. All that's Amnestic Isn't Alzheimer's: a Clinical Case Report of an Alzheimer's disease-like Amnestic Syndrome with Incongruent Biomarkers American Journal Of Geriatric Psychiatry 2022, 30: s24. DOI: 10.1016/j.jagp.2022.01.295.
- Mecca A, Ashton N, Chen M, O'Dell R, Naganawa M, Toyonaga T, Zhao W, Nabulsi N, Brinkmalm A, Kvartsberg H, Schöll M, Arnsten A, Huang Y, Blennow K, Zetterberg H, Carson R, van Dyck C, Nilsson J. Cerebrospinal fluid and brain PET measures of synaptic density glycoprotein 2A: Biomarkers of synaptic density in Alzheimer’s disease Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.054831.
- van Dyck C, Sharp E, O'Dell R, Banks E, Bartlett H, Chen M, Naganawa M, Toyonaga T, Harris J, Ni G, Zhao W, Nabulsi N, Wyk B, Huang Y, Arnsten A, Carson R, Mecca A. Synaptic density is associated with cognitive performance in Alzheimer’s disease: A PET imaging study with [11C]UCB‐J Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.054213.
- Datta D, Leslie SN, Woo E, Amancharla N, Elmansy A, Lepe M, Mecca AP, Slusher BS, Nairn AC, Arnsten AFT. Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance Frontiers In Aging Neuroscience 2021, 13: 760270. PMID: 34867287, PMCID: PMC8634091, DOI: 10.3389/fnagi.2021.760270.
- Zhou B, Wang R, Chen M, Mecca A, O’Dell R, Van Dyck C, Carson R, Duncan J, Liu C. Synthesizing Multi-tracer PET Images for Alzheimer’s Disease Patients Using a 3D Unified Anatomy-Aware Cyclic Adversarial Network 2021, 12906: 34-43. DOI: 10.1007/978-3-030-87231-1_4.
- Wang R, Liu H, Toyonaga T, Shi L, Wu J, Onofrey JA, Tsai Y, Naganawa M, Ma T, Liu Y, Chen M, Mecca AP, O’Dell R, Dyck C, Carson RE, Liu C. Generation of synthetic PET images of synaptic density and amyloid from 18F‐FDG images using deep learning Medical Physics 2021, 48: 5115-5129. PMID: 34224153, PMCID: PMC8455448, DOI: 10.1002/mp.15073.
- Lu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.
- Mecca AP, Rogers K, Jacobs Z, McDonald JW, Michalak HR, DellaGioia N, Zhao W, Hillmer AT, Nabulsi N, Lim K, Ropchan J, Huang Y, Matuskey D, Esterlis I, Carson RE, van Dyck CH. Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET NeuroImage 2021, 238: 118217. PMID: 34052464, PMCID: PMC8378132, DOI: 10.1016/j.neuroimage.2021.118217.
- Fang XT, Toyonaga T, Hillmer AT, Matuskey D, Holmes SE, Radhakrishnan R, Mecca AP, van Dyck CH, D’Souza D, Esterlis I, Worhunsky PD, Carson RE. Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis NeuroImage 2021, 237: 118167. PMID: 34000404, PMCID: PMC8452380, DOI: 10.1016/j.neuroimage.2021.118167.
- O'Dell R, Mecca A, Sharp E, Banks E, Bartlett H, Chen M, Naganawa M, Toyonaga T, Harris J, Ni G, Zhao W, Nabulsi N, Wyk B, Huang Y, Carson R, Arnsten A, van Dyck C. Synaptic Loss is Associated With Cognitive Impairment in Early Alzheimer’s Disease: A PET Imaging Study With [11C]UCB-J Biological Psychiatry 2021, 89: s107-s108. DOI: 10.1016/j.biopsych.2021.02.276.
- Pathak GA, Wendt FR, Levey DF, Mecca AP, van Dyck CH, Gelernter J, Polimanti R. Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression. Human Molecular Genetics 2021, 30: 1360-1370. PMID: 33831179, PMCID: PMC8255129, DOI: 10.1093/hmg/ddab102.
- van Dyck CH, O'Dell RS, Mecca AP. Amyloid-Associated Depression—or Not? Biological Psychiatry 2021, 89: 737-738. PMID: 33766236, PMCID: PMC8396710, DOI: 10.1016/j.biopsych.2021.02.008.
- O'Dell R, Mecca A, Chen M, Naganawa M, Toyonaga T, Lu Y, Godek T, Harris J, Bartlett H, Banks E, Kominek V, Zhao W, Nabulsi N, Ropchan J, Ye Y, Wyk B, Huang Y, Arnsten A, Carson R, van Dyck C. Association of Aß deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [11C]UCB-J American Journal Of Geriatric Psychiatry 2021, 29: s37-s40. DOI: 10.1016/j.jagp.2021.01.034.
- Sharp E, O'Dell R, Banks E, Bartlett H, Chen M, Naganawa M, Toyonaga T, Harris J, Ni G, Zhao W, Nabulsi N, Wyk B, Huang Y, Arnsten A, Carson R, Mecca A, van Dyck C. Synaptic density is associated with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB-J American Journal Of Geriatric Psychiatry 2021, 29: s119-s120. DOI: 10.1016/j.jagp.2021.01.114.
- Principal component analysis of synaptic density measured with [11C]UCB-J PET in Alzheimer's diseaseO'Dell R, Higgins-Chen A, Gupta D, Chen M, Naganawa M, Toyonaga T, Lu Y, Banks E, Bartlett H, Harris J, Zhao W, Nabulsi N, Wyk B, Huang Y, Arnsten A, Carson R, van Dyck C, Mecca A. Principal component analysis of synaptic density measured with [11C]UCB-J PET in Alzheimer's disease American Journal Of Geriatric Psychiatry 2021, 29: s47-s48. DOI: 10.1016/j.jagp.2021.01.041.
- Fahed M, Lane C, Khasnavis S, Mecca A. Recipes for Adult Learning: Innovations in teaching neuroimaging to geriatric trainees American Journal Of Geriatric Psychiatry 2021, 29: s16-s17. DOI: 10.1016/j.jagp.2021.02.022.
- Donovan N, Mecca A, Smith G, Gatchel J. Molecular Imaging in Alzheimer's Disease: Linking pathologic, neurotransmitter, synaptic and clinical findings relevant to geriatric psychiatry American Journal Of Geriatric Psychiatry 2021, 29: s8. DOI: 10.1016/j.jagp.2021.02.004.
- Gatchel J, Mecca A, Padala P. Developing Your Reseach Career American Journal Of Geriatric Psychiatry 2021, 29: s13-s14. DOI: 10.1016/j.jagp.2021.02.016.
- Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O’Dell R, McDonald JW, Michalak HR, Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study Cerebrovascular And Brain Metabolism Reviews 2021, 41: 2395-2409. PMID: 33757318, PMCID: PMC8393289, DOI: 10.1177/0271678x211004312.
- O’Dell R, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J Alzheimer's Research & Therapy 2021, 13: 11. PMID: 33402201, PMCID: PMC7786921, DOI: 10.1186/s13195-020-00742-y.
- Salardini A, Hillmer A, Mecca A, Hashemi‐Aghdam A, Laltoo E, Savoia S, O'Dell R, Harris J, Godek T, Nabulsi N, Lim K, Ropchan J, Huang Y, Cosgrove K, Carson R, Strittmatter S, van Dyck C. PBR28 Brain PET imaging with lipopolysaccharide challenge for the study of microglia function in Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.037792.
- Mecca A, Ashton N, Chen M, O'Dell R, Naganawa M, Toyonaga T, Harris J, Bartlett H, Banks E, Kominek V, Nabulsi N, Najafzadeh S, Wyk B, Brinkmalm A, Kvartsberg H, Schöll M, Arnsten A, Huang Y, Blennow K, Zetterberg H, Carson R, van Dyck C. Association between cerebrospinal fluid biomarkers of neurodegeneration and PET measurements of synaptic density in Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.044211.
- Salardini A, Hillmer A, Mecca A, Hashemi‐Aghdam A, Laltoo E, Savoia S, O'Dell R, Harris J, Godek T, Nabulsi N, Lim K, Ropchan J, Huang Y, Cosgrove K, Carson R, Strittmatter S, van Dyck C. 11C‐PBR28 brain PET imaging with lipopolysaccharide challenge for the study of microglia function in Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043584.
- O'Dell R, Mecca A, Chen M, Godek T, Harris J, Bartlett H, Banks E, Kominek V, Zhao W, Naganawa M, Toyonaga T, Lu Y, Nabulsi N, Ropchan J, Ye Y, Wyk B, Varma P, Arnsten A, Huang Y, Carson R, van Dyck C. Association between cerebral amyloid accumulation and synaptic density in Alzheimer’s disease: A multitracer PET study Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043631.
- Fang X, Mecca A, Naganawa M, O'Dell R, Chen M, van Dyck C, Carson R. ICA‐derived sources of synaptic density PET ([11C]UCB‐J) relate to cognitive impairment severity in Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.041197.
- Mecca A, O'Dell R, Chen M, Naganawa M, Toyonaga T, Godek T, Harris J, Bartlett H, Zhao W, Gallezot J, Nabulsi N, Ropchan J, Ye Y, Wyk B, Arnsten A, Huang Y, Carson R, van Dyck C. In vivo measurement of widespread synaptic loss and associated tau accumulation in early Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.037791.
- O'Dell R, Naganawa M, Toyonaga T, Young J, Dahal R, Singh E, Waheed A, Banks E, Harris J, Chen M, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Validation of a simplified tissue‐to‐reference ratio measurement using SUVR for the assessment of synaptic density alterations in Alzheimer’s disease using [11C]UCB‐J PET Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.045928.
- Mecca AP, Dyck C. Alzheimer's & Dementia: The Journal of the Alzheimer's Association Alzheimer's & Dementia 2020, 17: 316-317. PMID: 33047474, PMCID: PMC7962853, DOI: 10.1002/alz.12190.
- Naganawa M, Gallezot JD, Finnema SJ, Matuskey D, Mecca A, Nabulsi NB, Labaree D, Ropchan J, Malison RT, D'Souza DC, Esterlis I, Detyniecki K, van Dyck CH, Huang Y, Carson RE. Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort Journal Of Nuclear Medicine 2020, 62: 418-421. PMID: 32646875, PMCID: PMC8049341, DOI: 10.2967/jnumed.120.243949.
- Mecca AP, Chen M, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Nabulsi NB, Wyk BCV, Varma P, Arnsten AFT, Huang Y, Carson RE, Dyck C. In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET Alzheimer's & Dementia 2020, 16: 974-982. PMID: 32400950, PMCID: PMC7383876, DOI: 10.1002/alz.12097.
- Krystal HL, Ross DA, Mecca AP. Amyloid: From Starch to Finish Biological Psychiatry 2020, 87: e23-e24. PMID: 32299582, PMCID: PMC7449531, DOI: 10.1016/j.biopsych.2020.02.1182.
- O'Dell R, Mecca A, Chen M, Godek T, Harris J, Bartlett H, Zhao W, Naganawa M, Toyonaga T, Lu Y, Nabulsi N, Wyk B, Varma P, Arnsten A, Huang Y, Carson R, van Dyck C. ASSOCIATION BETWEEN CEREBRAL AMYLOID ACCUMULATION AND SYNAPTIC DENSITY IN ALZHEIMER'S DISEASE: A MULTITRACER PET STUDY American Journal Of Geriatric Psychiatry 2020, 28: s123-s124. DOI: 10.1016/j.jagp.2020.01.153.
- Fahed M, Lane C, Khasnavis S, Mecca A. Session 401 American Journal Of Geriatric Psychiatry 2020, 28: s38-s39. DOI: 10.1016/j.jagp.2020.01.070.
- Donovan N, Mecca A, Smith G, Gatchel J. Session 102 American Journal Of Geriatric Psychiatry 2020, 28: s4. DOI: 10.1016/j.jagp.2020.01.017.
- Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. PET imaging of mGluR5 in Alzheimer’s disease Alzheimer's Research & Therapy 2020, 12: 15. PMID: 31954399, PMCID: PMC6969979, DOI: 10.1186/s13195-020-0582-0.
- Kemp EC, Ebner MK, Ramanan S, Godek TA, Pugh EA, Bartlett HH, McDonald JW, Mecca MC, van Dyck CH, Mecca AP, Initiative T. Statin Use and Risk of Cognitive Decline in the ADNI Cohort American Journal Of Geriatric Psychiatry 2019, 28: 507-517. PMID: 31806426, PMCID: PMC7170771, DOI: 10.1016/j.jagp.2019.11.003.
- Mecca A, Chen M, Naganawa M, Toyonaga T, Godek T, Harris J, Bartlett H, Gallezot J, Charil A, Nabulsi N, Huang Y, Arnsten A, Carson R, Dyck C. P4‐481: ASSOCIATION BETWEEN ENTORHINAL CORTICAL TAU ACCUMULATION AND HIPPOCAMPAL SYNAPTIC DENSITY IN OLDER INDIVIDUALS WITH NORMAL COGNITION AND EARLY ALZHEIMER'S DISEASE: PRELIMINARY EXPERIENCE Alzheimer's & Dementia 2019, 15: p1497-p1497. DOI: 10.1016/j.jalz.2019.08.027.
- Mecca A, Chen M, Godek T, Harris J, Bartlett H, Toyonaga T, Naganawa M, Salardini A, Arnsten A, Nabulsi N, Lim K, Najafzadeh S, Ropchan J, Huang Y, Carson R, Strittmatter S, Dyck C. IC‐P‐140: ASSOCIATION BETWEEN MGLUR5 AND SYNAPTIC DENSITY: A MULTI‐TRACER STUDY IN HEALTHY AGING AND ALZHEIMER'S DISEASE Alzheimer's & Dementia 2019, 15: p115-p115. DOI: 10.1016/j.jalz.2019.06.4254.
- Mecca A, Chen M, Godek T, Harris J, Bartlett H, Toyonaga T, Naganawa M, Salardini A, Arnsten A, Nabulsi N, Lim K, Najafzadeh S, Ropchan J, Huang Y, Carson R, Strittmatter S, Dyck C. P2‐349: ASSOCIATION BETWEEN MGLUR5 AND SYNAPTIC DENSITY: A MULTI‐TRACER STUDY OF HEALTHY AGING AND ALZHEIMER'S DISEASE Alzheimer's & Dementia 2019, 15: p729-p729. DOI: 10.1016/j.jalz.2019.06.2756.
- Thomas JM, Mecca MC, Niehoff KM, Mecca AP, Van Ness PH, Brienza R, Hyson A, Jeffery S. Development and Validation of a Polypharmacy Knowledge Assessment Instrument. American Journal Of Pharmaceutical Education 2019, 83: 6435. PMID: 31333246, PMCID: PMC6630871, DOI: 10.5688/ajpe6435.
- Mecca AP. 1ciii AD molecular: Molecular imaging of Alzheimer's disease: PET imaging of neurotransmitter systems 2019, 165: 139-165. PMID: 31481161, DOI: 10.1016/bs.pmbts.2019.04.003.
- Mecca MC, Thomas JM, Niehoff KM, Hyson A, Jeffery SM, Sellinger J, Mecca AP, Van Ness PH, Fried TR, Brienza R. Assessing an Interprofessional Polypharmacy and Deprescribing Educational Intervention for Primary Care Post-graduate Trainees: a Quantitative and Qualitative Evaluation Journal Of General Internal Medicine 2019, 34: 1220-1227. PMID: 30972554, PMCID: PMC6614292, DOI: 10.1007/s11606-019-04932-9.
- Gupta M, O'Dell R, Gelernter J, Carson R, van Dyck C, Mecca A. ASSOCIATION BETWEEN ODOR IDENTIFICATION AND REGIONAL GRAY MATTER IN EARLY PRECLINICAL ALZHEIMER'S DISEASE American Journal Of Geriatric Psychiatry 2019, 27: s143-s144. DOI: 10.1016/j.jagp.2019.01.098.
- O'Dell R, Gupta M, Gelernter J, Carson R, van Dyck C, Mecca A. REGION-SPECIFIC ATROPHY AS MEASURED BY CORTICAL GRAY MATTER VOLUME IS ASSOCIATED WITH BOTH REGIONAL AND TOTAL CORTICAL AMYLOID-BETA BURDEN IN COGNITIVELY NORMAL INDIVIDUALS AT RISK FOR ALZHEIMER'S DISEASE American Journal Of Geriatric Psychiatry 2019, 27: s145-s146. DOI: 10.1016/j.jagp.2019.01.100.
- Mecca A, Smith G, Gatchel J, Donovan J. ADVANCES IN THE MOLECULAR IMAGING OF ALZHEIMER'S DISEASE: NEUROBIOLOGICAL MECHANISMS OF DISEASE AND NEUROPSYCHIATRIC SYMPTOMS Session 209 American Journal Of Geriatric Psychiatry 2019, 27: s17-s18. DOI: 10.1016/j.jagp.2019.01.158.
- Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging JAMA Neurology 2018, 75: 1215-1224. PMID: 30014145, PMCID: PMC6233853, DOI: 10.1001/jamaneurol.2018.1836.
- Pugh EA, Kemp EC, van Dyck CH, Mecca AP, Sharp ES, Initiative F. Effects of Normative Adjustments to the Montreal Cognitive Assessment American Journal Of Geriatric Psychiatry 2018, 26: 1258-1267. PMID: 30314940, PMCID: PMC6779033, DOI: 10.1016/j.jagp.2018.09.009.
- Mecca A, McDonald J, Michalak H, Godek T, Harris J, Chen M, Nabulsi N, Salardini A, Carson R, Strittmatter S, Dyck C. P1‐469: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASE Alzheimer's & Dementia 2018, 14: p501-p503. DOI: 10.1016/j.jalz.2018.06.479.
- Chen M, Mecca A, Naganawa M, Finnema S, Toyonaga T, Gallezot J, McDonald J, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, Dyck C. P2‐365: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCE Alzheimer's & Dementia 2018, 14: p832-p832. DOI: 10.1016/j.jalz.2018.06.1056.
- Mecca A, Chen M, Naganawa M, Finnema S, Toyonaga T, Lin S, Gallezot J, McDonald J, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, Dyck C. IC‐P‐183: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCE Alzheimer's & Dementia 2018, 14: p152-p153. DOI: 10.1016/j.jalz.2018.06.2250.
- Mecca A, McDonald J, Michalak H, Godek T, Harris J, Chen M, Nabulsi N, Salardini A, Carson R, Strittmatter S, Dyck C. IC‐04‐03: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASE Alzheimer's & Dementia 2018, 14: p8-p9. DOI: 10.1016/j.jalz.2018.06.2051.
- Mecca AP, Michalak HR, McDonald JW, Kemp EC, Pugh EA, Becker ML, Mecca MC, van Dyck CH. Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort Dementia And Geriatric Cognitive Disorders 2018, 45: 232-242. PMID: 29886490, PMCID: PMC6178799, DOI: 10.1159/000488671.
- Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial Neurobiology Of Aging 2018, 70: 117-124. PMID: 30007160, PMCID: PMC6503670, DOI: 10.1016/j.neurobiolaging.2018.05.033.
- Regenhardt RW, Mecca AP, Flavin SA, Boulouis G, Lauer A, Zachrison KS, Boomhower J, Patel AB, Hirsch JA, Schwamm LH, Leslie-Mazwi TM. Delays in the Air or Ground Transfer of Patients for Endovascular Thrombectomy Stroke 2018, 49: 1419-1425. PMID: 29712881, PMCID: PMC5970980, DOI: 10.1161/strokeaha.118.020618.
- Mecca A, Chen M, Naganawa M, Finnema S, Toyonaga T, Lin S, McDonald J, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C. Poster Number: NR 14 Initial Experience with PET Imaging of Synaptic Density (SV2A) in Alzheimer's Disease: A New Biomarker for Clinical Trials? American Journal Of Geriatric Psychiatry 2018, 26: s145-s146. DOI: 10.1016/j.jagp.2018.01.176.
- Mecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, Nadelmann J, Benincasa AL, Ropchan J, Huang Y, Gelernter J, Van Ness PH, Carson RE, van Dyck CH. Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease Neurobiology Of Aging 2017, 61: 207-214. PMID: 29111487, PMCID: PMC5722236, DOI: 10.1016/j.neurobiolaging.2017.09.027.
- Mecca A, Rogers K, Jacobs Z, McDonald J, Michalak H, DellaGioia N, Nabulsi N, Matuskey D, Esterlis I, Carson R, van Dyck C. Poster Number: EI 39 Investigating Age Related Associations of Metabotropic Glutamate Receptor 5 Density Using [18F]FPEB and PET American Journal Of Geriatric Psychiatry 2017, 25: s96-s97. DOI: 10.1016/j.jagp.2017.01.110.
- Hassell C, Mecca M, Mecca A. Poster Number: EI 40 Characteristics of Older Adults with Homelessness or Housing Instability American Journal Of Geriatric Psychiatry 2017, 25: s97-s99. DOI: 10.1016/j.jagp.2017.01.119.
- DeWorsop D, Mecca M, Maiaroto M, Rodriguez-Guzman J, Hassell C, Mecca A, Iheanacho T. Poster Number: EI 11 Screening PRogram to Identify Needs Due to Geriatric Syndromes (SPRING): A New Perspective on Healthcare for Homeless Adults American Journal Of Geriatric Psychiatry 2016, 24: s77-s79. DOI: 10.1016/j.jagp.2016.01.076.
- Hassell C, Mecca M, DeWorsop D, Rodriguez-Guzman J, Maiaroto M, Iheanacho T, Mecca A. Poster Number: EI 51 Characterizing Trajectories of Homelessness in Older Adults American Journal Of Geriatric Psychiatry 2016, 24: s116-s118. DOI: 10.1016/j.jagp.2016.01.116.
- Rodriguez-Guzman J, Maiaroto M, DeWorsop D, Hassell C, Iheanacho T, Mecca A, Mecca M. Poster Number: EI 10 Utilizing a Direct Assessment to Identify Functional Impairments in Homeless Adults American Journal Of Geriatric Psychiatry 2016, 24: s76-s77. DOI: 10.1016/j.jagp.2016.01.075.
- Dyck C, Mecca A, Wang S, Barcelos N, Planeta-Wilson B, Gelernter J, Ness P, Carson R. P3‐143: Amyloid burden is associated with decreased gray matter volume but not episodic memory performance in cognitively normal first‐degree relatives at varying ApoE4 risk for Alzheimer's disease Alzheimer's & Dementia 2015, 11: p680-p681. DOI: 10.1016/j.jalz.2015.06.1011.
- Dyck C, Mecca A, Wang S, Barcelos N, Planeta-Wilson B, Gelernter J, Ness P, Carson R. IC‐P‐101: Amyloid burden is associated with decreased gray matter volume but not episodic memory performance in cognitively normal first‐degree relatives at varying ApoE4 risk for Alzheimer's disease Alzheimer's & Dementia 2015, 11: p69-p69. DOI: 10.1016/j.jalz.2015.06.123.
- Bennion D, Regenhardt R, Mecca A, Sumners C. Chapter 28 Mas and Neuroprotection in Stroke 2015, 201-205. DOI: 10.1016/b978-0-12-801364-9.00028-6.
- Fineberg SK, Mecca A, Lerner BA, Hills OF, Corlett PR, Viron M. Idiom Use in a Young Man with Schizophrenia and Prominent Sexual Delusions Harvard Review Of Psychiatry 2014, 22: 306-315. PMID: 25188734, DOI: 10.1097/hrp.0000000000000053.
- Joseph JP, Mecca AP, Regenhardt RW, Bennion DM, Rodríguez V, Desland F, Patel NA, Pioquinto DJ, Unger T, Katovich MJ, Steckelings UM, Sumners C. The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke Neuropharmacology 2014, 81: 134-141. PMID: 24508710, PMCID: PMC7472595, DOI: 10.1016/j.neuropharm.2014.01.044.
- Regenhardt RW, Mecca AP, Desland F, Ritucci‐Chinni P, Ludin JA, Greenstein D, Banuelos C, Bizon JL, Reinhard MK, Sumners C. Centrally administered angiotensin‐(1–7) increases the survival of stroke‐prone spontaneously hypertensive rats Experimental Physiology 2013, 99: 442-453. PMID: 24142453, PMCID: PMC7416533, DOI: 10.1113/expphysiol.2013.075242.
- Regenhardt RW, Desland F, Mecca AP, Pioquinto DJ, Afzal A, Mocco J, Sumners C. Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke Neuropharmacology 2013, 71: 154-163. PMID: 23583926, PMCID: PMC3664115, DOI: 10.1016/j.neuropharm.2013.03.025.
- Regenhardt RW, Ansari S, Azari H, Caldwell KJ, Mecca AP. Utilizing a cranial window to visualize the middle cerebral artery during endothelin-1 induced middle cerebral artery occlusion. Journal Of Visualized Experiments 2013, e50015. PMID: 23463164, PMCID: PMC3605805, DOI: 10.3791/50015.
- Regenhardt R, Ansari S, Azari H, Caldwell K, Mecca A. Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion Journal Of Visualized Experiments 2013 DOI: 10.3791/50015-v.
- Ansari S, Azari H, Caldwell KJ, Regenhardt RW, Hedna VS, Waters MF, Hoh BL, Mecca AP. Endothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat. Journal Of Visualized Experiments 2013 PMID: 23438950, PMCID: PMC3601209, DOI: 10.3791/50014.
- Ansari S, Azari H, Caldwell K, Regenhardt R, Hedna V, Waters M, Hoh B, Mecca A. Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat Journal Of Visualized Experiments 2013 DOI: 10.3791/50014-v.
- Mecca AP, Regenhardt RW, O’Connor T, Joseph JP, Raizada MK, Katovich MJ, Sumners C. Cerebroprotection by angiotensin‐(1–7) in endothelin‐1‐induced ischaemic stroke Experimental Physiology 2011, 96: 1084-1096. PMID: 21685445, PMCID: PMC3210510, DOI: 10.1113/expphysiol.2011.058578.
- Regenhardt R, Ritucci‐Chinni P, Desland F, Mecca A, Sumners C. Angiotensin(1–7) increases survival of stroke‐prone spontaneously hypertensive rats The FASEB Journal 2011, 25: 650.10-650.10. DOI: 10.1096/fasebj.25.1_supplement.650.10.
- Joseph J, Regenhardt R, Mecca A, Patel N, Steckelings U, Unger T, Katovich M, Sumners C. Central and Peripheral Administration of Compound 21 Elicits Cerebroprotective Effects in Ischemic Stroke The FASEB Journal 2011, 25: lb576-lb576. DOI: 10.1096/fasebj.25.1_supplement.lb576.
- Cao W, Glushakov A, Shah HP, Mecca AP, Sumners C, Shi P, Seubert CN, Martynyuk AE. Halogenated aromatic amino acid 3,5-dibromo-d-tyrosine produces beneficial effects in experimental stroke and seizures Amino Acids 2010, 40: 1151-1158. PMID: 20839013, PMCID: PMC8396070, DOI: 10.1007/s00726-010-0739-4.
- Ferreira AJ, Santos RA, Bradford CN, Mecca AP, Sumners C, Katovich MJ, Raizada MK. Therapeutic Implications of the Vasoprotective Axis of the Renin-Angiotensin System in Cardiovascular Diseases Hypertension 2009, 55: 207-213. PMID: 20038757, PMCID: PMC2826213, DOI: 10.1161/hypertensionaha.109.140145.
- Cao W, Shah H, Glushakov A, Mecca A, Shi P, Sumners C, Seubert C, Martynyuk A. Efficacy of 3,5‐dibromo‐L‐phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit British Journal Of Pharmacology 2009, 158: 2005-2013. PMID: 20050189, PMCID: PMC2807662, DOI: 10.1111/j.1476-5381.2009.00498.x.
- Martynyuk A, Sumners C, Cao W, Shah H, Mecca A, Seubert C. FP19-TU-03 3,5-Dibromo-l-phenylalanine depresses pentylenetetrazole-induced seizures and reduces neurological and sensorimotor gating deficits caused by stroke Journal Of The Neurological Sciences 2009, 285: s87. DOI: 10.1016/s0022-510x(09)70364-8.
- Mecca AP, O'Connor TE, Katovich MJ, Sumners C. Candesartan pretreatment is cerebroprotective in a rat model of endothelin‐1‐induced middle cerebral artery occlusion Experimental Physiology 2009, 94: 937-946. PMID: 19429641, PMCID: PMC2742297, DOI: 10.1113/expphysiol.2009.047936.
- Mecca A, O'Connor T, Dooies K, Katovich M, Sumners C. Cerebroprotective action of angiotensin 1‐7 in a rat model of ischemic stroke The FASEB Journal 2009, 23: 947.1-947.1. DOI: 10.1096/fasebj.23.1_supplement.947.1.
- Shi P, Jiang N, Li H, Mecca A, Raizada M, Sumners C. Paraventricular nucleus (PVN) neurons projecting to the rostral ventrolateral medulla (RVLM) contain both oxytocin and glutamate The FASEB Journal 2009, 23: 967.6-967.6. DOI: 10.1096/fasebj.23.1_supplement.967.6.
- Overexpression of Angiotensin II type 2 receptor (AT2R) in neonatal cardiomyocytes induces apoptosisQi Y, Li H, Mecca A, Shenoy V, Sumners C, Katovich M. Overexpression of Angiotensin II type 2 receptor (AT2R) in neonatal cardiomyocytes induces apoptosis The FASEB Journal 2008, 22: 1238.18-1238.18. DOI: 10.1096/fasebj.22.1_supplement.1238.18.
- Grobe J, Mecca A, Lingis M, Shenoy V, Bolton T, Machado J, Speth R, Raizada M, Katovich M. Angiotensin‐(1–7) prevents cardiac remodeling during angiotensin II‐induced hypertension The FASEB Journal 2007, 21: a896-a897. DOI: 10.1096/fasebj.21.6.a896-d.
- Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1–7) AJP Heart And Circulatory Physiology 2006, 292: h736-h742. PMID: 17098828, DOI: 10.1152/ajpheart.00937.2006.
- Mitra A, Katovich MJ, Mecca A, Rowland NE. Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats Physiology & Behavior 2006, 89: 221-225. PMID: 16839572, DOI: 10.1016/j.physbeh.2006.06.006.
- Grobe J, Mecca A, Lingis M, Mao H, Katovich M. Angiotensin 1‐7 prevents cardiac fibrosis in angiotensin II and DOCA‐salt models of hypertension The FASEB Journal 2006, 20: a305-a306. DOI: 10.1096/fasebj.20.4.a305-d.
- Grobe JL, Mecca AP, Mao H, Katovich MJ. Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension AJP Heart And Circulatory Physiology 2006, 290: h2417-h2423. PMID: 16415071, DOI: 10.1152/ajpheart.01170.2005.
- Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. Protection from angiotensin II‐induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats Experimental Physiology 2005, 90: 783-790. PMID: 16049057, DOI: 10.1113/expphysiol.2005.031096.