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Multimodal Outcome CHAracterization (MOCHA) in comatose cardiac arrest patients

  • Study HIC#:1506016080REG
  • Last Updated:07/15/2021

The purpose of this study is to create a Yale School of Medicine Neurology patient clinical data repository that will be used for current and future research projects involving the study of post-cardiac arrest patients and the clinical characteristics and prognostic factors that effect neurologic outcome. This clinical data repository will serve researchers at Yale as well as external collaborators engaged in future observational studies related to post-cardiac arrest syndrome. The clinical data registry will gather a patient's relevant clinical data, including functional outcomes during hospitalization and at discharge (at 3 months, 6 months and 12 months follow-up visits). The clinical information obtained from patients will help researchers understand the target patient population as well as help formulate studies that can assess the progression of disease as it relates to outcome. Our ultimate goal is to come up with a predication model for prognostication in cardiac arrest, using multiple modalities that are already clinically in use, but in a more standardized fashion. Our hope is that these tools, either in isolate or in combination, will be able to more accurately predict outcome for patients initially comatose following cardiac arrest.

  • Age18 years and older
  • GenderBoth
  • Start Date01/01/2004
  • End Date12/31/2025

Trial Purpose and Description

The purpose of this study is to create a Yale School of Medicine Neurology patient clinical data repository that will be used for current and future research projects involving the study of post-cardiac arrest patients and the clinical characteristics and prognostic factors that effect neurologic outcome. This clinical data repository will serve researchers at Yale as well as external collaborators engaged in future observational studies related to post-cardiac arrest syndrome. The clinical data registry will gather a patient's relevant clinical data, including functional outcomes during hospitalization and at discharge (at 3 months, 6 months and 12 months follow-up visits). The clinical information obtained from patients will help researchers understand the target patient population as well as help formulate studies that can assess the progression of disease as it relates to outcome. Our ultimate goal is to come up with a predication model for prognostication in cardiac arrest, using multiple modalities that are already clinically in use, but in a more standardized fashion. Our hope is that these tools, either in isolate or in combination, will be able to more accurately predict outcome for patients initially comatose following cardiac arrest.

Eligibility Criteria

Inclusion Criteria:

a) Adult patients (age 18 or older with no upper age limit)
b) Cardiac arrest from any non-perfusing cardiac rhythm
c) Sustained return of spontaneous circulation (ROSC)*

*Sustained ROSC: Sustained ROSC is when chest compressions have been not required for 20 consecutive minutes and signs of circulation persist.

Exclusion Criteria:

a) Subjects with isolated respiratory arrest without concomitant or ensuing cardiac arrest;

b) Patients younger than 18 years of age.

Sub-Investigators

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