Tore Eid, MD, PhD
Pathology, Laboratory Medicine
Titles
- Professor of Laboratory Medicine, of Neurosurgery and of Molecular Physiology
- Associate Director, Clinical Chemistry Laboratory, Yale-New Haven Hospital
Education & Training
- ResidentYale University (2007)
- PhDUniversity of Bergen (1999)
- MDUniversity of Bergen (1992)
Additional Information
Honors & Recognitions
- Innovator Award: Citizens United for Research in Epilepsy (2017)
- Teaching Award for Residents in Clinical Pathology: Yale New Haven Hospital (2017)
- Translational Career Development Award: Yale Center for Clinical Investigation (2010)
- Thomas Buchholz Research Prize: Yale University School of Medicine (2005)
- Fulbright Scholarship: University of Maryland at Baltimore (1993), (1994)
Board Certifications
- AB of Pathology, Clinical Pathology (2013)
Professional Service
- Americal Epilepsy Society (2019 - Present): Scientific advisor for Epilepsy Current.
- National Institutes for Neurological Disorders and Stoke & American Epilepsy Society (2018 - Present): Member of Epilepsy Benchmark Committee.
- International League Against Epilepsy (2018 - Present): Member in task force on the role of "omics" technologies in epilepsy research.
- Science Translational Medicine (2013 - 2014): Associate scientific advisor for Science Translational Medicine.
Publications
- Bindila L, Eid T, Mills JD, Hildebrand MS, Brennan GP, Masino SA, Whittemore V, Perucca P, Reid CA, Patel M, Wang KK, Vliet E. A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force Epilepsia Open 2022 PMID: 36259125, DOI: 10.1002/epi4.12662.
- Vliet E, Hildebrand MS, Mills JD, Brennan GP, Eid T, Masino SA, Whittemore V, Bindila L, Wang KK, Patel M, Perucca P, Reid CA. A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force Epilepsia Open 2022 PMID: 35950645, DOI: 10.1002/epi4.12640.
- Eid T, Zaveri HP. Catch the Rhythm! Epilepsy Currents 2022, 22: 249-251. PMID: 36187149, PMCID: PMC9483758, DOI: 10.1177/15357597221099066.
- Gueorguieva R, Schwartz EKC, MacLean RR, DeVito EE, Eid T, Wu R, O’Malley S, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans Frontiers In Pharmacology 2022, 13: 844824. PMID: 35431934, PMCID: PMC9009207, DOI: 10.3389/fphar.2022.844824.
- Vera MA, Eid T, El-Khoury JM. Effects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real? Clinical Chemistry 2022, 68: 607-608. PMID: 36103316, DOI: 10.1093/clinchem/hvab222.
- MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration Experimental And Clinical Psychopharmacology 2022 PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.
- De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.
- Eid T. Harnessing Metabolomics to Advance Epilepsy Research Epilepsy Currents 2022, 22: 123-129. PMID: 35444500, PMCID: PMC8988727, DOI: 10.1177/15357597221074518.
- Eid T. Transforming Glia to Neurons Effectively Treats Temporal Lobe Seizures Epilepsy Currents 2022, 22: 130-131. PMID: 35444496, PMCID: PMC8988719, DOI: 10.1177/15357597211073013.
- Eid T. Brain Energy Oscillations–A Possible Explanation for Seizure Periodicity in Epilepsy? Epilepsy Currents 2021, 21: 447-448. PMID: 34924854, PMCID: PMC8652326, DOI: 10.1177/15357597211043517.
- Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity Epilepsia 2021, 62: 2858-2870. PMID: 34536233, PMCID: PMC9006438, DOI: 10.1111/epi.17072.
- Jackson A, Green B, Erythropel HC, Kong G, Cavallo DA, Eid T, Gueorguieva R, Buta E, O’Malley S, Krishnan-Sarin S. Influence of Menthol and Green Apple E-Liquids Containing Different Nicotine Concentrations Among Youth E-Cigarette Users Experimental And Clinical Psychopharmacology 2021, 29: 355-365. PMID: 32297782, PMCID: PMC7572568, DOI: 10.1037/pha0000368.
- Eid T. Progressive Neuronal Loss in Epilepsy – A Long-Standing Conundrum Finally Resolved? Epilepsy Currents 2021, 21: 366-368. PMID: 34924838, PMCID: PMC8655263, DOI: 10.1177/15357597211030385.
- Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain Epilepsia 2021, 62: e88-e97. PMID: 33949690, DOI: 10.1111/epi.16920.
- Eid T. Localizing the Seizure Onset Site Through Metabolic Imaging of GABA Epilepsy Currents 2021, 21: 282-284. PMID: 34690567, PMCID: PMC8512926, DOI: 10.1177/15357597211011988.
- Sandhu MRS, Gruenbaum BF, Gruenbaum SE, Dhaher R, Deshpande K, Funaro MC, Lee TW, Zaveri HP, Eid T. Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy Frontiers In Neurology 2021, 12: 665334. PMID: 33927688, PMCID: PMC8078591, DOI: 10.3389/fneur.2021.665334.
- MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.
- Dhaher R, Gruenbaum SE, Sandhu MRS, Ottestad-Hansen S, Tu N, Wang Y, Lee TW, Deshpande K, Spencer DD, Danbolt NC, Zaveri HP, Eid T. Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis. Neurology 2021, 96: e2261-e2271. PMID: 33722994, PMCID: PMC8166437, DOI: 10.1212/wnl.0000000000011846.
- Ebersole J, Rose G, Eid T, Behar K, Patrylo P. Altered hippocampal astroglial metabolism is associated with aging and preserved spatial learning and memory Neurobiology Of Aging 2021, 102: 188-199. PMID: 33774381, DOI: 10.1016/j.neurobiolaging.2021.02.015.
- Eid T. Ticktock—What Is the Seizure Driving Clock? Epilepsy Currents 2021, 21: 122-123. PMID: 34025290, PMCID: PMC8010871, DOI: 10.1177/1535759721989672.
- Lee TS, Li AY, Rapuano A, Mantis J, Eid T, Seyfried TN, de Lanerolle NC. Gene expression in the epileptic (EL) mouse hippocampus Neurobiology Of Disease 2020, 147: 105152. PMID: 33153970, DOI: 10.1016/j.nbd.2020.105152.
- Zhou Y, Eid T, Hassel B, Danbolt NC. Novel aspects of glutamine synthetase in ammonia homeostasis Neurochemistry International 2020, 140: 104809. PMID: 32758585, DOI: 10.1016/j.neuint.2020.104809.
- Sandhu MRS, Dhaher R, Gruenbaum SE, Raaisa R, Spencer DD, Pavlova MK, Zaveri HP, Eid T. Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy Frontiers In Neurology 2020, 11: 398. PMID: 32499751, PMCID: PMC7242976, DOI: 10.3389/fneur.2020.00398.
- Binder DK, Boison D, Eid T, Frankel WN, Mingorance A, Smith BN, Dacks PA, Whittemore V, Poduri A, . Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression Epilepsy Currents 2020, 20: 14s-22s. PMID: 31937124, PMCID: PMC7031802, DOI: 10.1177/1535759719895274.
- Eid T. An Ancient Enzyme Takes a Hit in Epilepsy Epilepsy Currents 2019, 19: 400-401. PMID: 31530017, PMCID: PMC6891189, DOI: 10.1177/1535759719875468.
- Eid T, Lee T, Patrylo P, Zaveri HP. Astrocytes and Glutamine Synthetase in Epileptogenesis Journal Of Neuroscience Research 2018, 97: 1345-1362. PMID: 30022509, PMCID: PMC6338538, DOI: 10.1002/jnr.24267.
- Eid T, Ghosh A, Wang Y, Beckström H, Zaveri HP, Lee TS, Lai JC, Malthankar-Phatak GH, de Lanerolle NC. Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats Brain 2008, 131: 2061-2070. PMID: 18669513, PMCID: PMC2724901, DOI: 10.1093/brain/awn133.
- Bjørnsen LP, Eid T, Holmseth S, Danbolt NC, Spencer DD, de Lanerolle NC. Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures Neurobiology Of Disease 2006, 25: 319-330. PMID: 17112731, DOI: 10.1016/j.nbd.2006.09.014.
- Eid T, Thomas M, Spencer D, Rundén-Pran E, Lai J, Malthankar G, Kim J, Danbolt N, Ottersen O, de Lanerolle N. Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy The Lancet 2004, 363: 28-37. PMID: 14723991, DOI: 10.1016/s0140-6736(03)15166-5.
- Du F, Eid T, Schwarcz R. Neuronal damage after the injection of amino-oxyacetic acid into the rat entorhinal cortex: a silver impregnation study Neuroscience 1997, 82: 1165-1178. PMID: 9466438, DOI: 10.1016/s0306-4522(97)00354-0.
- Eid T, Jorritsma-Byham B, Schwarcz R, Witter MP. Afferents to the seizure-sensitive neurons in layer III of the medial entorhinal area: a tracing study in the rat Experimental Brain Research 1996, 109: 209-218. PMID: 8738371, DOI: 10.1007/bf00231782.
- Eid T, Du F, Schwarcz R. Differential neuronal vulnerability to amino-oxyacetate and quinolinate in the rat parahippocampal region Neuroscience 1995, 68: 645-656. PMID: 8577365, DOI: 10.1016/0306-4522(95)00183-j.
- Du F, Eid T, Lothman E, Kohler C, Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy Journal Of Neuroscience 1995, 15: 6301-6313. PMID: 7472396, PMCID: PMC6577998, DOI: 10.1523/jneurosci.15-10-06301.1995.
Patient Care Organizations
Titles
- Professor of Laboratory Medicine, of Neurosurgery and of Molecular Physiology
- Associate Director, Clinical Chemistry Laboratory, Yale-New Haven Hospital
Education & Training
- ResidentYale University (2007)
- PhDUniversity of Bergen (1999)
- MDUniversity of Bergen (1992)
Additional Information
Honors & Recognitions
- Innovator Award: Citizens United for Research in Epilepsy (2017)
- Teaching Award for Residents in Clinical Pathology: Yale New Haven Hospital (2017)
- Translational Career Development Award: Yale Center for Clinical Investigation (2010)
- Thomas Buchholz Research Prize: Yale University School of Medicine (2005)
- Fulbright Scholarship: University of Maryland at Baltimore (1993), (1994)
Board Certifications
- AB of Pathology, Clinical Pathology (2013)
Professional Service
- Americal Epilepsy Society (2019 - Present): Scientific advisor for Epilepsy Current.
- National Institutes for Neurological Disorders and Stoke & American Epilepsy Society (2018 - Present): Member of Epilepsy Benchmark Committee.
- International League Against Epilepsy (2018 - Present): Member in task force on the role of "omics" technologies in epilepsy research.
- Science Translational Medicine (2013 - 2014): Associate scientific advisor for Science Translational Medicine.
Publications
- Bindila L, Eid T, Mills JD, Hildebrand MS, Brennan GP, Masino SA, Whittemore V, Perucca P, Reid CA, Patel M, Wang KK, Vliet E. A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force Epilepsia Open 2022 PMID: 36259125, DOI: 10.1002/epi4.12662.
- Vliet E, Hildebrand MS, Mills JD, Brennan GP, Eid T, Masino SA, Whittemore V, Bindila L, Wang KK, Patel M, Perucca P, Reid CA. A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force Epilepsia Open 2022 PMID: 35950645, DOI: 10.1002/epi4.12640.
- Eid T, Zaveri HP. Catch the Rhythm! Epilepsy Currents 2022, 22: 249-251. PMID: 36187149, PMCID: PMC9483758, DOI: 10.1177/15357597221099066.
- Gueorguieva R, Schwartz EKC, MacLean RR, DeVito EE, Eid T, Wu R, O’Malley S, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans Frontiers In Pharmacology 2022, 13: 844824. PMID: 35431934, PMCID: PMC9009207, DOI: 10.3389/fphar.2022.844824.
- Vera MA, Eid T, El-Khoury JM. Effects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real? Clinical Chemistry 2022, 68: 607-608. PMID: 36103316, DOI: 10.1093/clinchem/hvab222.
- MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration Experimental And Clinical Psychopharmacology 2022 PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.
- De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.
- Eid T. Harnessing Metabolomics to Advance Epilepsy Research Epilepsy Currents 2022, 22: 123-129. PMID: 35444500, PMCID: PMC8988727, DOI: 10.1177/15357597221074518.
- Eid T. Transforming Glia to Neurons Effectively Treats Temporal Lobe Seizures Epilepsy Currents 2022, 22: 130-131. PMID: 35444496, PMCID: PMC8988719, DOI: 10.1177/15357597211073013.
- Eid T. Brain Energy Oscillations–A Possible Explanation for Seizure Periodicity in Epilepsy? Epilepsy Currents 2021, 21: 447-448. PMID: 34924854, PMCID: PMC8652326, DOI: 10.1177/15357597211043517.
- Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity Epilepsia 2021, 62: 2858-2870. PMID: 34536233, PMCID: PMC9006438, DOI: 10.1111/epi.17072.
- Jackson A, Green B, Erythropel HC, Kong G, Cavallo DA, Eid T, Gueorguieva R, Buta E, O’Malley S, Krishnan-Sarin S. Influence of Menthol and Green Apple E-Liquids Containing Different Nicotine Concentrations Among Youth E-Cigarette Users Experimental And Clinical Psychopharmacology 2021, 29: 355-365. PMID: 32297782, PMCID: PMC7572568, DOI: 10.1037/pha0000368.
- Eid T. Progressive Neuronal Loss in Epilepsy – A Long-Standing Conundrum Finally Resolved? Epilepsy Currents 2021, 21: 366-368. PMID: 34924838, PMCID: PMC8655263, DOI: 10.1177/15357597211030385.
- Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain Epilepsia 2021, 62: e88-e97. PMID: 33949690, DOI: 10.1111/epi.16920.
- Eid T. Localizing the Seizure Onset Site Through Metabolic Imaging of GABA Epilepsy Currents 2021, 21: 282-284. PMID: 34690567, PMCID: PMC8512926, DOI: 10.1177/15357597211011988.
- Sandhu MRS, Gruenbaum BF, Gruenbaum SE, Dhaher R, Deshpande K, Funaro MC, Lee TW, Zaveri HP, Eid T. Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy Frontiers In Neurology 2021, 12: 665334. PMID: 33927688, PMCID: PMC8078591, DOI: 10.3389/fneur.2021.665334.
- MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.
- Dhaher R, Gruenbaum SE, Sandhu MRS, Ottestad-Hansen S, Tu N, Wang Y, Lee TW, Deshpande K, Spencer DD, Danbolt NC, Zaveri HP, Eid T. Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis. Neurology 2021, 96: e2261-e2271. PMID: 33722994, PMCID: PMC8166437, DOI: 10.1212/wnl.0000000000011846.
- Ebersole J, Rose G, Eid T, Behar K, Patrylo P. Altered hippocampal astroglial metabolism is associated with aging and preserved spatial learning and memory Neurobiology Of Aging 2021, 102: 188-199. PMID: 33774381, DOI: 10.1016/j.neurobiolaging.2021.02.015.
- Eid T. Ticktock—What Is the Seizure Driving Clock? Epilepsy Currents 2021, 21: 122-123. PMID: 34025290, PMCID: PMC8010871, DOI: 10.1177/1535759721989672.
- Lee TS, Li AY, Rapuano A, Mantis J, Eid T, Seyfried TN, de Lanerolle NC. Gene expression in the epileptic (EL) mouse hippocampus Neurobiology Of Disease 2020, 147: 105152. PMID: 33153970, DOI: 10.1016/j.nbd.2020.105152.
- Zhou Y, Eid T, Hassel B, Danbolt NC. Novel aspects of glutamine synthetase in ammonia homeostasis Neurochemistry International 2020, 140: 104809. PMID: 32758585, DOI: 10.1016/j.neuint.2020.104809.
- Sandhu MRS, Dhaher R, Gruenbaum SE, Raaisa R, Spencer DD, Pavlova MK, Zaveri HP, Eid T. Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy Frontiers In Neurology 2020, 11: 398. PMID: 32499751, PMCID: PMC7242976, DOI: 10.3389/fneur.2020.00398.
- Binder DK, Boison D, Eid T, Frankel WN, Mingorance A, Smith BN, Dacks PA, Whittemore V, Poduri A, . Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression Epilepsy Currents 2020, 20: 14s-22s. PMID: 31937124, PMCID: PMC7031802, DOI: 10.1177/1535759719895274.
- Eid T. An Ancient Enzyme Takes a Hit in Epilepsy Epilepsy Currents 2019, 19: 400-401. PMID: 31530017, PMCID: PMC6891189, DOI: 10.1177/1535759719875468.
- Eid T, Lee T, Patrylo P, Zaveri HP. Astrocytes and Glutamine Synthetase in Epileptogenesis Journal Of Neuroscience Research 2018, 97: 1345-1362. PMID: 30022509, PMCID: PMC6338538, DOI: 10.1002/jnr.24267.
- Eid T, Ghosh A, Wang Y, Beckström H, Zaveri HP, Lee TS, Lai JC, Malthankar-Phatak GH, de Lanerolle NC. Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats Brain 2008, 131: 2061-2070. PMID: 18669513, PMCID: PMC2724901, DOI: 10.1093/brain/awn133.
- Bjørnsen LP, Eid T, Holmseth S, Danbolt NC, Spencer DD, de Lanerolle NC. Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures Neurobiology Of Disease 2006, 25: 319-330. PMID: 17112731, DOI: 10.1016/j.nbd.2006.09.014.
- Eid T, Thomas M, Spencer D, Rundén-Pran E, Lai J, Malthankar G, Kim J, Danbolt N, Ottersen O, de Lanerolle N. Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy The Lancet 2004, 363: 28-37. PMID: 14723991, DOI: 10.1016/s0140-6736(03)15166-5.
- Du F, Eid T, Schwarcz R. Neuronal damage after the injection of amino-oxyacetic acid into the rat entorhinal cortex: a silver impregnation study Neuroscience 1997, 82: 1165-1178. PMID: 9466438, DOI: 10.1016/s0306-4522(97)00354-0.
- Eid T, Jorritsma-Byham B, Schwarcz R, Witter MP. Afferents to the seizure-sensitive neurons in layer III of the medial entorhinal area: a tracing study in the rat Experimental Brain Research 1996, 109: 209-218. PMID: 8738371, DOI: 10.1007/bf00231782.
- Eid T, Du F, Schwarcz R. Differential neuronal vulnerability to amino-oxyacetate and quinolinate in the rat parahippocampal region Neuroscience 1995, 68: 645-656. PMID: 8577365, DOI: 10.1016/0306-4522(95)00183-j.
- Du F, Eid T, Lothman E, Kohler C, Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy Journal Of Neuroscience 1995, 15: 6301-6313. PMID: 7472396, PMCID: PMC6577998, DOI: 10.1523/jneurosci.15-10-06301.1995.
Patient Care Organizations