Samir Gautam, MD/PhD
Titles
- Instructor
Education & Training
- Clinical FellowYale School of Medicine (2021)
- ABIM PSTP ResidentYale School of Medicine (2017)
- MD/PhDYale School of Medicine, Cell Biology (2015)
- BSBoston College, Biology; Music (2006)
Additional Information
Honors & Recognitions
- Doris Duke FRCS at Yale Award: (2022)
- Patterson Trust Mentored Research Award: Robert Leet Patterson and Clara Guthrie Patterson Trust (2021)
- YCCI Scholar Award (KL-2 career development award): Yale Center for Clinical Investigation (2021)
- Janeway Society Member: Janeway Society for Junior Faculty at Yale (2021)
- Parker B. Francis Fellowship (career development award): Parker B. Francis Foundation (2021)
- Finalist: Annual Respiratory Disease Young Investigators’ Forum (2020)
- F32 Postdoctoral Individual National Research Service Award: NIH/NHLBI (2020)
- Cystic Fibrosis Foundation Fellowship: Cystic Fibrosis Foundation (2020)
- ATS Abstract Scholarship Award: American Thoracic Society (2019)
- Fellow of the Year Award: Yale University, Department of Internal Medicine (2018)
Professional Service
- Annals of the American Thoracic Society (2022 - 2023): Reviewer
- Yale Medical School Physiology Case Conference (2022 - 2023): Contributor
- American Thoracic Society, Pulmonary Infection Network of Experts (2021): Invited lecture on COVID-19 pathothogenesis
- Yale University Postgraduate Research Program (2021 - Present): Mentor to Eric Jung, BS
- Yale Internal Medicine PSTP interviewer (2021 - Present): Interviewer
- AstraZeneca (2021): Participant
- European Respiratory Journal (2021 - 2022): Reviewer
- Yale Internal Medicine Mentor-Advisor-Coach Program (2021 - Present): Mentor
- American Journal of Respiratory and Critical Care Medicine (2020 - 2021): Reviewer
- Yale University Postgraduate Research Program (2019): Mentor to Yannick Stahl, MS (visiting German scholar)
Publications
- Kunitomo Y, Young G, Datta R, Korn LL, Tanoue L, Gautam S. A 62-Year-Old Woman With Lung Cancer, Ulcerating Rash, and Rapidly Progressive Hypoxemia. Chest 2020, 158: e191-e196. PMID: 33036118, PMCID: PMC7533682, DOI: 10.1016/j.chest.2020.06.020.
- Gautam S, Stahl Y, Young GM, Howell R, Cohen AJ, Tsang DA, Martin T, Sharma L, Dela Cruz CS. Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2020, 319: L661-L669. PMID: 32783617, PMCID: PMC7642899, DOI: 10.1152/ajplung.00316.2020.
- Gautam S, Cohen AJ, Stahl Y, Valda Toro P, Young GM, Datta R, Yan X, Ristic NT, Bermejo SD, Sharma L, Restrepo M, Dela Cruz CS. Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia. Thorax 2020, 75: 974-981. PMID: 32826284, DOI: 10.1136/thoraxjnl-2020-214896.
- Gautam S, Kim T, Howell R, Spiegel DA. Fluorescent stem peptide mimics: In situ probes for peptidoglycan crosslinking. Methods In Enzymology 2020, 638: 57-67. PMID: 32416921, DOI: 10.1016/bs.mie.2020.02.016.
- Gautam S, Sharma L, Dela Cruz CS. Teaching an Old Intensivist Neutrophil Tricks: Using Alveolar Neutrophilia to Diagnose Ventilator-associated Pneumonia. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 1178-1181. PMID: 30543457, PMCID: PMC6519853, DOI: 10.1164/rccm.201811-2163ED.
- Gautam S, Sharma L, Dela Cruz CS. Personalizing the Management of Pneumonia. Clinics In Chest Medicine 2018, 39: 871-900. PMID: 30390755, DOI: 10.1016/j.ccm.2018.08.008.
- Gautam S, Sharma L, Dela Cruz CS, Spiegel DA. A Slick Solution to a Sticky Problem. Biochemistry 2018, 57: 5923-5924. PMID: 30289246, DOI: 10.1021/acs.biochem.8b00916.
- Gautam S, Kim T, Lester E, Deep D, Spiegel DA. Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus. ACS Chemical Biology 2016, 11: 25-30. PMID: 26502318, PMCID: PMC5592732, DOI: 10.1021/acschembio.5b00439.
- Gautam S, Kim T, Shoda T, Sen S, Deep D, Luthra R, Ferreira MT, Pinho MG, Spiegel DA. An Activity-Based Probe for Studying Crosslinking in Live Bacteria. Angewandte Chemie (International Ed. In English) 2015, 54: 10492-6. PMID: 26204841, DOI: 10.1002/anie.201503869.
- Gautam S, Kim T, Spiegel DA. Chemical probes reveal an extraseptal mode of cross-linking in Staphylococcus aureus. Journal Of The American Chemical Society 2015, 137: 7441-7. PMID: 26035224, DOI: 10.1021/jacs.5b02972.
- Pushing the bacterial envelope: Strategies for re-engineering bacterial surfaces with heterologous proteins and sugars.Gautam S, Spiegel DA. Zhao, W. & Karp, J. (Eds.). 2014. Micro- and Nanoengineering of the Cell Surface. Oxford, UK: Elsevier.
- Gautam S, Gniadek TJ, Kim T, Spiegel DA. Exterior design: strategies for redecorating the bacterial surface with small molecules. Trends In Biotechnology 2013, 31: 258-67. PMID: 23490213, PMCID: PMC3641905, DOI: 10.1016/j.tibtech.2013.01.012.
- Kruglov EA, Gautam S, Guerra MT, Nathanson MH. Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes. Hepatology (Baltimore, Md.) 2011, 54: 1790-9. PMID: 21748767, PMCID: PMC3205211, DOI: 10.1002/hep.24548.
- Shah AU, Sarwar A, Orabi AI, Gautam S, Grant WM, Park AJ, Shah AU, Liu J, Mistry PK, Jain D, Husain SZ. Protease activation during in vivo pancreatitis is dependent on calcineurin activation. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2009, 297: G967-73. PMID: 20501444, PMCID: PMC2777459, DOI: 10.1152/ajpgi.00181.2009.
- Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology 2009, 136: 1060-9. PMID: 19027009, PMCID: PMC3439851, DOI: 10.1053/j.gastro.2008.10.025.
- Dela Cruz CS, Evans SE, Restrepo MI, Dean N, Torres A, Amara-Elori I, Awasthi S, Caler E, Cao B, Chalmers JD, Chastre J, Cohen TS, Cohen AH, Crothers K, Di YP, Egan ME, Feldman C, Gautam S, Halstead ES, Herold S, Jones BE, Luna C, Niederman MS, Mendez R, Menendez R, Mizgerd JP, Nusrat R, Ramirez J, Shindo Y, Waterer G, Yeligar SM, Wunderink RG. Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2021, 18: 1087-1097. PMID: 34242148, PMCID: PMC8328365, DOI: 10.1513/AnnalsATS.202102-209ST.
Titles
- Instructor
Education & Training
- Clinical FellowYale School of Medicine (2021)
- ABIM PSTP ResidentYale School of Medicine (2017)
- MD/PhDYale School of Medicine, Cell Biology (2015)
- BSBoston College, Biology; Music (2006)
Additional Information
Honors & Recognitions
- Doris Duke FRCS at Yale Award: (2022)
- Patterson Trust Mentored Research Award: Robert Leet Patterson and Clara Guthrie Patterson Trust (2021)
- YCCI Scholar Award (KL-2 career development award): Yale Center for Clinical Investigation (2021)
- Janeway Society Member: Janeway Society for Junior Faculty at Yale (2021)
- Parker B. Francis Fellowship (career development award): Parker B. Francis Foundation (2021)
- Finalist: Annual Respiratory Disease Young Investigators’ Forum (2020)
- F32 Postdoctoral Individual National Research Service Award: NIH/NHLBI (2020)
- Cystic Fibrosis Foundation Fellowship: Cystic Fibrosis Foundation (2020)
- ATS Abstract Scholarship Award: American Thoracic Society (2019)
- Fellow of the Year Award: Yale University, Department of Internal Medicine (2018)
Professional Service
- Annals of the American Thoracic Society (2022 - 2023): Reviewer
- Yale Medical School Physiology Case Conference (2022 - 2023): Contributor
- American Thoracic Society, Pulmonary Infection Network of Experts (2021): Invited lecture on COVID-19 pathothogenesis
- Yale University Postgraduate Research Program (2021 - Present): Mentor to Eric Jung, BS
- Yale Internal Medicine PSTP interviewer (2021 - Present): Interviewer
- AstraZeneca (2021): Participant
- European Respiratory Journal (2021 - 2022): Reviewer
- Yale Internal Medicine Mentor-Advisor-Coach Program (2021 - Present): Mentor
- American Journal of Respiratory and Critical Care Medicine (2020 - 2021): Reviewer
- Yale University Postgraduate Research Program (2019): Mentor to Yannick Stahl, MS (visiting German scholar)
Publications
- Kunitomo Y, Young G, Datta R, Korn LL, Tanoue L, Gautam S. A 62-Year-Old Woman With Lung Cancer, Ulcerating Rash, and Rapidly Progressive Hypoxemia. Chest 2020, 158: e191-e196. PMID: 33036118, PMCID: PMC7533682, DOI: 10.1016/j.chest.2020.06.020.
- Gautam S, Stahl Y, Young GM, Howell R, Cohen AJ, Tsang DA, Martin T, Sharma L, Dela Cruz CS. Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2020, 319: L661-L669. PMID: 32783617, PMCID: PMC7642899, DOI: 10.1152/ajplung.00316.2020.
- Gautam S, Cohen AJ, Stahl Y, Valda Toro P, Young GM, Datta R, Yan X, Ristic NT, Bermejo SD, Sharma L, Restrepo M, Dela Cruz CS. Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia. Thorax 2020, 75: 974-981. PMID: 32826284, DOI: 10.1136/thoraxjnl-2020-214896.
- Gautam S, Kim T, Howell R, Spiegel DA. Fluorescent stem peptide mimics: In situ probes for peptidoglycan crosslinking. Methods In Enzymology 2020, 638: 57-67. PMID: 32416921, DOI: 10.1016/bs.mie.2020.02.016.
- Gautam S, Sharma L, Dela Cruz CS. Teaching an Old Intensivist Neutrophil Tricks: Using Alveolar Neutrophilia to Diagnose Ventilator-associated Pneumonia. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 1178-1181. PMID: 30543457, PMCID: PMC6519853, DOI: 10.1164/rccm.201811-2163ED.
- Gautam S, Sharma L, Dela Cruz CS. Personalizing the Management of Pneumonia. Clinics In Chest Medicine 2018, 39: 871-900. PMID: 30390755, DOI: 10.1016/j.ccm.2018.08.008.
- Gautam S, Sharma L, Dela Cruz CS, Spiegel DA. A Slick Solution to a Sticky Problem. Biochemistry 2018, 57: 5923-5924. PMID: 30289246, DOI: 10.1021/acs.biochem.8b00916.
- Gautam S, Kim T, Lester E, Deep D, Spiegel DA. Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus. ACS Chemical Biology 2016, 11: 25-30. PMID: 26502318, PMCID: PMC5592732, DOI: 10.1021/acschembio.5b00439.
- Gautam S, Kim T, Shoda T, Sen S, Deep D, Luthra R, Ferreira MT, Pinho MG, Spiegel DA. An Activity-Based Probe for Studying Crosslinking in Live Bacteria. Angewandte Chemie (International Ed. In English) 2015, 54: 10492-6. PMID: 26204841, DOI: 10.1002/anie.201503869.
- Gautam S, Kim T, Spiegel DA. Chemical probes reveal an extraseptal mode of cross-linking in Staphylococcus aureus. Journal Of The American Chemical Society 2015, 137: 7441-7. PMID: 26035224, DOI: 10.1021/jacs.5b02972.
- Pushing the bacterial envelope: Strategies for re-engineering bacterial surfaces with heterologous proteins and sugars.Gautam S, Spiegel DA. Zhao, W. & Karp, J. (Eds.). 2014. Micro- and Nanoengineering of the Cell Surface. Oxford, UK: Elsevier.
- Gautam S, Gniadek TJ, Kim T, Spiegel DA. Exterior design: strategies for redecorating the bacterial surface with small molecules. Trends In Biotechnology 2013, 31: 258-67. PMID: 23490213, PMCID: PMC3641905, DOI: 10.1016/j.tibtech.2013.01.012.
- Kruglov EA, Gautam S, Guerra MT, Nathanson MH. Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes. Hepatology (Baltimore, Md.) 2011, 54: 1790-9. PMID: 21748767, PMCID: PMC3205211, DOI: 10.1002/hep.24548.
- Shah AU, Sarwar A, Orabi AI, Gautam S, Grant WM, Park AJ, Shah AU, Liu J, Mistry PK, Jain D, Husain SZ. Protease activation during in vivo pancreatitis is dependent on calcineurin activation. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2009, 297: G967-73. PMID: 20501444, PMCID: PMC2777459, DOI: 10.1152/ajpgi.00181.2009.
- Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology 2009, 136: 1060-9. PMID: 19027009, PMCID: PMC3439851, DOI: 10.1053/j.gastro.2008.10.025.
- Dela Cruz CS, Evans SE, Restrepo MI, Dean N, Torres A, Amara-Elori I, Awasthi S, Caler E, Cao B, Chalmers JD, Chastre J, Cohen TS, Cohen AH, Crothers K, Di YP, Egan ME, Feldman C, Gautam S, Halstead ES, Herold S, Jones BE, Luna C, Niederman MS, Mendez R, Menendez R, Mizgerd JP, Nusrat R, Ramirez J, Shindo Y, Waterer G, Yeligar SM, Wunderink RG. Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2021, 18: 1087-1097. PMID: 34242148, PMCID: PMC8328365, DOI: 10.1513/AnnalsATS.202102-209ST.