Oliver Karam, MD, PhD
Pediatric Critical Care Medicine
Biography
Oliver Karam, MD, PhD, specializes in pediatric critical care medicine. He diagnoses and treats severe health issues in critically ill children and manages life-threatening conditions using advanced life support systems, as well as addressing common complications such as bleeding and thrombosis (severe blood clots that block normal blood flow).
As a professor of pediatrics at Yale School of Medicine, Dr. Karam conducts research on blood transfusion strategies in critically ill children. He aims to improve outcomes by refining definitions and treatment protocols for bleeding and thrombotic complications. He also explores the use of extracorporeal membrane oxygenation (ECMO, a form of advanced, short-term life support for patients with heart or lung failure) and analyzes its psychological impacts on parents, guiding efforts to enhance family support.
“What drew me to pediatric critical care is the combination of treating very sick children and seeing how quickly many of them recover,” Dr. Karam says. “In the pediatric intensive care unit, we often care for children at their most critical moment, yet with the right care and teamwork, the vast majority improve and are able to go home to their families.”
Dr. Karam also values the opportunity to work on research that can improve care for critically ill children: “The goal is not only to help the patients we treat today, but also to develop evidence that can improve outcomes for the millions of children who require intensive care around the world each year.”
Dr. Karam received his medical degree from the University of Geneva in Switzerland, where he also completed a residency in pediatrics, and then pursued fellowship in pediatric critical care medicine at the University of Montreal. He received his doctoral degree in clinical research at the University of Lille in France.
Titles
- Professor of Pediatrics (Critical Care Medicine)
- Chief of Pediatric Critical Care, Pediatrics
Education & Training
- FellowshipUniversity of Geneva (2021)
- FellowshipUniversity of Montreal (2021)
- PhDUniversity of Lille (2017)
- MScUniversity of Montreal (2011)
- FellowshipSainte Justine Hospital (2010)
- ResidentGeneva University Hospital (2007)
- MDUniversity of Geneva (2002)
Languages Spoken
- English
- Français (French)
Additional Information
Publications
- Hendrickson J, Birch R, Sola-Visner M, Branchford B, Chen X, Custer B, Desimone R, Bougie D, Edwards E, Goel R, Gottschall J, Hod E, Moayeri M, Roubinian N, Karam O, Stone E, Luban N, Josephson C, Patel R. International classification of diseases codes have low positive predictive value for neonatal morbidities. Journal Of Perinatology 2025, 1-2. PMID: 41310310, PMCID: PMC12716811, DOI: 10.1038/s41372-025-02470-3.
- Calamusa J, Karam O, Li W, Labarinas S. Avoiding unnecessary massive transfusion protocol activation in paediatric trauma: Development of the activation of massive transfusion in children score. Vox Sanguinis 2025 PMID: 41253356, DOI: 10.1111/vox.70154.
- Labarinas S, Norbisrath K, Nnaemeka I, Bai Y, Tint H, Johnson D, Brady K, Karam O. Plasma Exchange in the Setting of Immune‐Mediated Multiple Organ Failure in the Cardiac ICU During ECMO: A Case Series. Journal Of Clinical Apheresis 2025, 40: e70061. PMID: 41046521, DOI: 10.1002/jca.70061.
- Patel R, Hendrickson J, Birch R, Bougie D, Branchford B, Chen X, Custer B, Desimone R, Edwards E, Goel R, Gottschall J, Hod E, Moayeri M, Karam O, Stone E, Luban N, Josephson C, Sola-Visner M, Study-IV-Pediatric N. Temporal Trends in Red Blood Cell and Platelet Transfusion Thresholds for Extremely Low Birth Weight Infants. The Journal Of Pediatrics 2025, 288: 114797. PMID: 40887015, PMCID: PMC12533266, DOI: 10.1016/j.jpeds.2025.114797.
- Karam O, Atchison C, Chegondi M. Why Outcome Definition Precedes Risk of Bias Assessment in Extracorporeal Membrane Oxygenation Bleeding Research. ASAIO Journal 2025 PMID: 40747890, DOI: 10.1097/mat.0000000000002527.
- Labarinas S, Karam O. Transfusion Medicine in the Pediatric Intensive Care Unit. 2025, 643-656. DOI: 10.1007/978-3-031-64762-8_40.
- El Amin N, Karam O. Haemoglobinopathies and Haemostatic Disorders in the PICU. 2025, 627-641. DOI: 10.1007/978-3-031-64762-8_39.
- Hickey K, Smith M, Karam O, Demetres M, Faraoni D, Duron V, Wu Y, Nellis M. The Effect of Prophylactic Use of Antifibrinolytics During Pediatric Non‐Cardiac Surgeries on Bleeding and Transfusions: A Systematic Review and Meta‐Analysis. Pediatric Anesthesia 2025, 35: 668-683. PMID: 40476647, DOI: 10.1111/pan.15137.
- Atchison C, Chegondi M, Aldairi N, Carmona C, Mahmood H, Levasseur J, Funaro M, Faustino E, Nellis M, Willems A, Labarinas S, Karam O. Bleeding Definitions in Pediatric Extracorporeal Membrane Oxygenation (ECMO) Studies: A Systematic Review and Meta-Analysis. ASAIO Journal 2025 PMID: 40397688, DOI: 10.1097/mat.0000000000002468.
- Ingle T, Simms B, Bain J, Bembea M, Cholette J, Chegondi M, Cheung E, Niebler R, Ozment C, Paden M, Schiller O, Nellis M, Karam O. Platelet transfusion stated practices among neonatal and paediatric veno‐arterial extracorporeal membrane oxygenation providers: A survey. Vox Sanguinis 2025, 120: 597-604. PMID: 40097240, DOI: 10.1111/vox.70018.
- Demory A, Broden E, Equey L, Funaro M, Sharifi M, Harpaz-Rotem I, Traube C, Karam O. 123: TRAUMA-RELATED PSYCHOPATHOLOGIES AFTER EXTRACORPOREAL MEMBRANE OXYGENATION SUPPORT. Critical Care Medicine 2025, 53 DOI: 10.1097/01.ccm.0001099156.06691.67.
- Chegondi M, Jawahar A, Hrvojevic L, Karam O. 479: ASSOCIATION OF MEAN PLATELET VOLUME WITH BLEEDING AND CLOTTING RISKS ON ECMO. Critical Care Medicine 2025, 53 DOI: 10.1097/01.ccm.0001100580.64131.de.
- Atchison C, Chegondi M, Aldairi N, Carmona C, Mahmood H, Faustino E, Nellis M, Willems A, Labarinas S, Karam O. 525: BLEEDING DEFINITIONS IN EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) STUDIES. Critical Care Medicine 2025, 53 DOI: 10.1097/01.ccm.0001100764.36791.95.
- Demory A, Broden E, Equey L, Funaro M, Sharifi M, Harpaz-Rotem I, Traube C, Karam O, Organization I. Trauma-related psychopathologies after extracorporeal membrane oxygenation support: A systematic review and meta-analysis. Perfusion 2025, 40: 1546-1558. PMID: 39879146, DOI: 10.1177/02676591251317919.
- Carmona C, Bain J, Karam O. Concordance and discordance of anticoagulation assays in children supported by ECMO: The truth is out there. Perfusion 2024, 40: 1592-1599. PMID: 39719141, DOI: 10.1177/02676591241309841.
- Nellis M, Chegondi M, Willems A, Alqatani M, McMichael A, Aran A, Lerner R, Karam O, Investigators A. Assessing the Reliability of the Bleeding Assessment Scale in Critically Ill Children (BASIC) Definition: A Prospective Cohort Study. Pediatric Critical Care Medicine 2024, 26: e3-e11. PMID: 39560732, PMCID: PMC11774477, DOI: 10.1097/pcc.0000000000003638.
- Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Muszynski J. OP037 Topic: AS06–Extracorporeal Organ Support: ECMO/Ventricular Assist Devices (Temporary & Durable)/MARS/Total Plasma Exchange/Plasmapheresis/Other: PEDIATRIC EXTRACORPOREAL MEMBRANE OXYGENATION ANTICOAGULATION COLLABORATIVE (PEACE) CONSENSUS CONFERENCE. Pediatric Critical Care Medicine 2024, 25: e14-e14. DOI: 10.1097/01.pcc.0001084600.19979.1a.
- Johnson A, Szczepiorkowski Z, Balogun R, Karam O, Nellis M, Schneiderman J, Schwartz J, Winters J, Wu Y, Armendariz T, Burgstaler E, Collins L, Geile K, Pavenski K, Sanchez A, Witt V, Muthusamy A, Pederson T, Ramesh V, Thao M, Chlebeck T, Zantek N. Development of a Uniform Apheresis Case Report Form for Standardized Collection of Apheresis Data. Journal Of Clinical Apheresis 2024, 39: e22146. PMID: 39420527, PMCID: PMC11523286, DOI: 10.1002/jca.22146.
- Alexander P, Di Nardo M, Combes A, Vogel A, Antonini M, Barrett N, Benedetti G, Bettencourt A, Brodie D, Gómez-Gutiérrez R, Gorga S, Hodgson C, Kapoor P, Le J, MacLaren G, O’Neil E, Ostermann M, Paden M, Patel N, Rojas-Peña A, Said A, Sperotto F, Willems A, Vercaemst L, Yoganathan A, Lorts A, del Nido P, Barbaro R, Organization E, Network I, Investigators P, subgroup of PALISI and ELSO P, Care E, Group A, Society I, Society P, Network A, Consortium C, Association A, Surgeons S, Medicine S, Abecasis F, Al Foudri H, Anders M, Angus D, Annich G, Arachchillage D, Akcan-Arikan A, Armstrong A, Balcells J, Barrett M, Bartlett R, Belda-Hofheinz S, Bembea M, Best D, Bonadonna D, Boonstra P, Brogan T, Brown K, Butragueño-Laiseca L, Butt W, Camporota L, Cardenas B, Cascarano M, Caspi J, Chen E, Chiletti R, Colombo G, Conte M, Crowe L, Cvetkovic M, Dalton H, Daverio M, Davidson M, Davis C, DiGeronimo R, Egbunine A, Ellis W, Fan E, Foster C, Fraser J, Friedman M, Furlong-Dillard J, Fynn-Thompson F, Garcia A, Geppert J, Gillette N, Grazioli L, Greene C, Guerguerian A, Guilliams K, Fortis J, Hao J, Heinsar S, Hejduk M, Himebauch A, Horvat C, Hoskote A, Hou X, Hyslop R, Ibrahim N, Ito T, Karagiannidis C, Karam O, Kaushik S, Kilbaugh T, Kim-Campbell N, Kirsch R, Kormos R, Kornberger A, Krucoff M, Lakshminrusimha S, LaRovere K, Leger P, Levy P, Lorusso R, Lyster H, Malone M, McMullan D, Mečířová S, Mehran R, Merz S, Mochizuki S, Moler F, Molla K, Monagle P, Morgan G, Morgan C, Morice M, Muszynski J, Najaf T, Nellis M, Newburger J, O'Rourke P, Ostadal P, Ozment C, Pagani F, Peek G, Polito A, Priest J, Raman L, Rintoul N, Roy N, Rubin J, Rumford M, Rycus P, Ryerson L, Sakamoto W, Segura-Matute S, Shekar K, Spinella P, Spitzer E, Starr J, Stead C, Steffen K, Steiner M, Tan L, Tasker R, Taylor J, Thiagarajan R, Tonna J, Ubertini G, van Leeuwen G, Vang E, Ventetuolo C, Venugopal P, Weinberg A, Westrope C, Wu C, Wylie G, Zeymer U, Zivick E, Zochios V. Definitions of adverse events associated with extracorporeal membrane oxygenation in children: results of an international Delphi process from the ECMO-CENTRAL ARC. The Lancet Child & Adolescent Health 2024, 8: 773-780. PMID: 39299748, DOI: 10.1016/s2352-4642(24)00132-9.
- Hughes T, Treffalls R, Koek W, Dalton H, Karam O, Meyer A. Comprehensive secondary analysis of thrombotic events in pediatric patients receiving extracorporeal membrane oxygenation: A prospective cohort study. Perfusion 2024, 40: 1202-1209. PMID: 39352407, PMCID: PMC12202824, DOI: 10.1177/02676591241289358.
- Labarinas S, Norbisrath K, Johnson D, Brady K, Karam O. 196: Plasma exchange in the setting of immune-mediated multiple organ failure in the Cardiac ICU during ECMO, a case series. ASAIO Journal 2024, 70: 83-83. DOI: 10.1097/01.mat.0001070312.98485.e2.
- Karam O, Ahmed A, Bizzarro M, Bogue C, Giuliano J, Collaborative P, Al-Subu A, Bateman S, Berning E, Brown K, Bulut Y, Cheifetz I, Chegondi M, Cholette J, Cowl A, Ceneviva G, Gehlbach J, Hobson M, Kudchadkar S, Labarinas S, Louis C, Miller M, Marinello M, Malone M, Nair A, Nishisaki A, Lowrie L, Rehder K, Rozenfeld R, Schneider J, Sequeira J, Shein S, Stalets E, Taylor J, Yager P. Physical space of thirty pediatric intensive care units in the United States of America: a national survey. Frontiers In Pediatrics 2024, 12: 1473805. PMID: 39359742, PMCID: PMC11445063, DOI: 10.3389/fped.2024.1473805.
- Ozment C, Alexander P, Chandler W, Emani S, Hyslop R, Monagle P, Muszynski J, Willems A, Gehred A, Lyman E, Steffen K, Thiagarajan R, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman M, Muszynski J. Anticoagulation Monitoring and Targets: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e14-e24. PMID: 38959356, PMCID: PMC11216399, DOI: 10.1097/pcc.0000000000003494.
- Cashen K, Saini A, Brandão L, Le J, Monagle P, Moynihan K, Ryerson L, Gehred A, Lyman E, Muszynski J, Alexander P, Dalton H, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepall S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. Anticoagulant Medications: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e7-e13. PMID: 38959355, PMCID: PMC11216397, DOI: 10.1097/pcc.0000000000003495.
- Rintoul N, McMichael A, Bembea M, DiGeronimo R, Patregnani J, Alexander P, Muszynski J, Steffen K, Gehred A, Lyman E, Cheifetz I, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nico K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. Management of Bleeding and Thrombotic Complications During Pediatric Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e66-e77. PMID: 38959361, PMCID: PMC11216396, DOI: 10.1097/pcc.0000000000003489.
- Himebauch A, Priest J, Annich G, McMullan D, Turner D, Muszynski J, Alexander P, Paden M, Gehred A, Lyman E, Said A, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. The Influence of the Extracorporeal Membrane Oxygenation Circuit and Components on Anticoagulation Management: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e1-e6. PMID: 38959354, PMCID: PMC11216392, DOI: 10.1097/pcc.0000000000003496.
- Willems A, Anders M, Garcia A, Vogel A, Yates A, Muszynski J, Alexander P, Steffen K, Emani S, Gehred A, Lyman E, Raman L, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, FCIC F, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. Management of Extracorporeal Membrane Oxygenation Anticoagulation in the Perioperative Period: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e53-e65. PMID: 38959360, PMCID: PMC11216378, DOI: 10.1097/pcc.0000000000003490.
- Muszynski J, Bembea M, Gehred A, Lyman E, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Alexander P, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. Priorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e78-e89. PMID: 38959362, PMCID: PMC11216398, DOI: 10.1097/pcc.0000000000003488.
- Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J, in collaboration with the Pediatric Acute Lung Injury and Sepsis Investigators Network T. Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference*. Pediatric Critical Care Medicine 2024, 25: 643-675. PMID: 38959353, PMCID: PMC11216385, DOI: 10.1097/pcc.0000000000003480.
- Nellis M, Moynihan K, Sloan S, Delaney M, Kneyber M, DiGeronimo R, Alexander P, Muszynski J, Gehred A, Lyman E, Karam O, in collaboration with the Pediatric Critical Care Blood Research Network A. Prophylactic Transfusion Strategies in Children Supported by Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e25-e34. PMID: 38959357, PMCID: PMC11216389, DOI: 10.1097/pcc.0000000000003493.
- Labarinas S, Norbisrath K, Johnson D, Meliones J, Greenleaf C, Salazar J, Karam O. Clinical outcomes in critically ill children on extracorporeal membrane oxygenation with severe thrombocytopenia. Perfusion 2024, 40: 590-598. PMID: 38626382, DOI: 10.1177/02676591241247981.
- Chegondi M, Jawahar A, Hrvojevic L, Badheka A, Karam O. 426: PLATELET MASS INDEX AND RISKS OF BLEEDING AND CLOTTING ON EXTRACORPOREAL MEMBRANE OXYGENATION. Critical Care Medicine 2023, 52: s187-s187. DOI: 10.1097/01.ccm.0000999884.03955.ef.
- Pierce J, Li W, Karam O, Labarinas S. 1578: SCORING SYSTEM FOR EARLY ACTIVATION OF MASSIVE TRANSFUSION PROTOCOLS IN PEDIATRIC TRAUMA PATIENTS. Critical Care Medicine 2023, 52: s760-s760. DOI: 10.1097/01.ccm.0001004468.85444.22.
- Hickey K, Smith M, Karam O, Faraoni D, Demetres M, Duron V, Wu Y, Nellis M. 804: THE EFFICACY OF ANTIFIBRINOLYTICS IN ADOLESCENTS UNDERGOING SCOLIOSIS SURGERY. Critical Care Medicine 2023, 52: s374-s374. DOI: 10.1097/01.ccm.0001001384.14980.68.
- Smith M, Hickey K, Karam O, Faraoni D, Demetres M, Duron V, Wu Y, Nellis M. 793: THE EFFICACY OF ANTIFIBRINOLYTICS IN CHILDREN UNDERGOING CRANIOFACIAL SURGERY. Critical Care Medicine 2023, 52: s369-s369. DOI: 10.1097/01.ccm.0001001340.99864.51.
- Nellis M, Karam O, Aldave G, Rocque B, Bauer D, Network I. Scenario Decision-Making About Plasma and Platelet Transfusion for Intracranial Monitor Placement: Cross-Sectional Survey of Pediatric Intensivists and Neurosurgeons. Pediatric Critical Care Medicine 2023, 25: e205-e213. PMID: 37966339, PMCID: PMC10994730, DOI: 10.1097/pcc.0000000000003414.
- Labarinas S, Singh K, Meliones J, Johnson D, Greenleaf C, Salazar J, Karam O. 105: Clinical Outcomes in Critically Ill Children on Extracorporeal Membrane Oxygenation with Severe Thrombocytopenia. ASAIO Journal 2023, 69: 57-57. DOI: 10.1097/01.mat.0000990932.67126.dc.
- Levasseur J, Fikse L, Mauguen A, Killinger J, Karam O, Nellis M. Bleeding in Critically Ill Children With Malignancy or Hematopoietic Cell Transplant: A Single-Center Prospective Cohort Study. Pediatric Critical Care Medicine 2023, 24: e602-e610. PMID: 37678406, PMCID: PMC10843653, DOI: 10.1097/pcc.0000000000003374.
- Greenfield K, Karam O, O'Meara A. Stuck in the Dark: No Association between Light, Sound, and Delirium in the PICU. Journal Of Pediatric Intensive Care 2023 DOI: 10.1055/s-0043-1770081.
- Aldairi N, Al Ali A, Alabdulqader M, Al Jeraisy M, Cyrus J, Karam O. Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis. Cureus 2023, 15: e39967. PMID: 37416033, PMCID: PMC10320736, DOI: 10.7759/cureus.39967.
- Goel R, Zhu X, Makhani S, Josephson C, White J, Karam O, Nellis M, Gehrie E, Sherpa M, Crowe E, Bloch E, Tobian A. Pediatric firearm injury related emergency department visits and hospitalizations: a population-based study in the United States. The Lancet Regional Health - Americas 2023, 22: 100503. PMID: 37214769, PMCID: PMC10192937, DOI: 10.1016/j.lana.2023.100503.
- Goldstein G, Karam O, Miller Ferguson N. The Effects of Expectation Setting and Bundle Consent on Acute Caregiver Stress in the PICU: A Randomized Controlled Trial. Pediatric Critical Care Medicine 2023, 24: 692-700. PMID: 37125809, DOI: 10.1097/pcc.0000000000003265.
- Carmona C, Nellis M, Karam O. Anticoagulation and hemostasis on extracorporeal membrane oxygenation. Current Opinion In Pediatrics 2023, 35: 297-302. PMID: 36974451, DOI: 10.1097/mop.0000000000001247.
- Cousin V, Rodriguez-Vigouroux R, Karam O, Rimensberger P, Posfay-Barbe K. First nosocomial infections in children supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO). BMC Pediatrics 2023, 23: 89. PMID: 36823601, PMCID: PMC9948414, DOI: 10.1186/s12887-023-03908-3.
- Carmona C, Kuziez M, Freitas C, Cyrus J, Bain J, Karam O. Cardiac manifestations of multisystem inflammatory syndrome of children after SARS-CoV-2 infection: a systematic review and meta-analysis. Cardiology In The Young 2023, 33: 2319-2327. PMID: 36762563, DOI: 10.1017/s104795112300015x.
- Nellis M, An A, Mahmood H, Prishtina F, Hena Z, Karam O. Epidemiology of anticoagulation for children supported by extracorporeal membrane oxygenation in the United States: A Pediatric Hospital Information System database study. Perfusion 2023, 39: 536-542. PMID: 36606508, DOI: 10.1177/02676591221151027.
- Shenker J, Abuelhija H, Karam O, Nellis M. Transfusion Strategies in the 21st Century A Case-Based Narrative Report. Critical Care Clinics 2022, 39: 287-298. PMID: 36898774, DOI: 10.1016/j.ccc.2022.09.005.
- Schertz K, Karam O, Demetres M, Mayadunna S, Faraoni D, Nellis ME. Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis. Pediatric Critical Care Medicine 2022, 23: e517-e529. PMID: 35997516, DOI: 10.1097/pcc.0000000000003049.
- Amigoni A, Simons S, De Hoog M, De Wildt SN, Karam O. Editorial: Sedation and analgesia challenges in critically ill neonates and children. Frontiers In Pediatrics 2022, 10: 1003736. PMID: 36061397, PMCID: PMC9434329, DOI: 10.3389/fped.2022.1003736.
- El-Amin N, Iness A, Cyrus JW, Sisler I, Karam O. Anticoagulation strategies and recurrence of venous thromboembolic events in patients with sickle cell disease: a systematic review and meta-analysis. Annals Of Hematology 2022, 101: 1931-1940. PMID: 35895101, DOI: 10.1007/s00277-022-04901-z.
- Dengler BA, Karam O, Barthol CA, Chance A, Snider LE, Mundy CM, Bounajem MT, Johnson WC, Maita MM, Mendez-Gomez PM, Seifi A, Hafeez S. Ketamine Boluses Are Associated with a Reduction in Intracranial Pressure and an Increase in Cerebral Perfusion Pressure: A Retrospective Observational Study of Patients with Severe Traumatic Brain Injury. Critical Care Research And Practice 2022, 2022: 3834165. PMID: 35637760, PMCID: PMC9148235, DOI: 10.1155/2022/3834165.
- Chegondi M, Vijayakumar N, Badheka A, Karam O. Effect of Platelet Transfusions on Extracorporeal Life Support Oxygenator’s Function. Frontiers In Pediatrics 2022, 10: 826477. PMID: 35321010, PMCID: PMC8936087, DOI: 10.3389/fped.2022.826477.
- Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Network A. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB). Pediatric Critical Care Medicine 2022, 23: 34-51. PMID: 34989711, PMCID: PMC8820267, DOI: 10.1097/pcc.0000000000002851.
- Lieberman L, Karam O, Stanworth SJ, Goobie SM, Crighton G, Goel R, Lacroix J, Nellis ME, Parker RI, Steffen K, Stricker P, Valentine SL, Steiner ME, Network A. Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e37-e49. PMID: 34989704, PMCID: PMC8769367, DOI: 10.1097/pcc.0000000000002857.
- Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Network A. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e1-e13. PMID: 34989701, PMCID: PMC8769352, DOI: 10.1097/pcc.0000000000002854.
- Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yehya N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. 2022, 149: s1-s12. PMID: 34970673, PMCID: PMC9599725, DOI: 10.1542/peds.2021-052888b.
- Faustino EVS, Karam O, Parker RI, Hanson SJ, Brandão LR, Monagle P. Coagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. 2022, 149: s79-s83. PMID: 34970670, DOI: 10.1542/peds.2021-052888l.
- John J, Division of Pediatric Nephrology C, Gipson G, King C, Bunchman T, Karam O, Division of Nephrology V, Division of Pediatric Critical Care Medicine C. Accuracy of Bioimpedance Modalities for Fluid Assessment in Hemodialysis Patients: A Randomized Observational Study. Nephrology - Open Journal 2021, 6: 1-7. DOI: 10.17140/npoj-6-124.
- Tarquinio KM, Karsies T, Shein SL, Beardsley A, Khemani R, Schwarz A, Smith L, Flori H, Karam O, Cao Q, Haider Z, Smirnova E, Serrano MG, Buck GA, Willson DF. Airway microbiome dynamics and relationship to ventilator‐associated infection in intubated pediatric patients. Pediatric Pulmonology 2021, 57: 508-518. PMID: 34811963, PMCID: PMC8809006, DOI: 10.1002/ppul.25769.
- Grunauer M, Mikesell C, Bustamante G, Aronowitz D, Zambrano K, Icaza-Freire A, Gavilanes A, Barrera R, Group T, González J, López-Herce J, Rossetti E, Fabrizio C, Karam O, Saint-Faust M, Biban P, Carlassara S, von Dessauer B, Ordenes N, Urízar F, A A, Canarie M, Miller K, Irazuzta J, Tawfik D, Tucker E, Shilkofski N, Wenchao W, Yuxia Z, See L, Priscilla, Tekin R, Aktar F, Düzkaya D, Dursun O, Ongun E, Yilmaz R, Yildizdas D, Tekgüç H, Sazonov V, Tsoy T, Sazonov V, Saparov A, Sazonov V, Kalmbakh E, Grunauer M, Quiñones E, Eguiguren L, Briones K, Tovilla Y, Gómez S, Torres S, Cobarrubias P, Dmytriiev D, Martínez A, Guzaman G, Sanabria R, Krupanandan R, Ramachandran B, Choraria N, Patel J, Pooni P, Gill K, Appiah J, Heye T, Argaw R, Demtse A, Admasu I. Availability and Quality of Grief and Bereavement Care in Pediatric Intensive Care Units Around the World, Opportunities for Improvement. Frontiers In Pediatrics 2021, 9: 742916. PMID: 34869100, PMCID: PMC8634722, DOI: 10.3389/fped.2021.742916.
- Romano J, Martinez M, Levasseur J, Killinger JS, Karam O, Nellis ME. Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis. Critical Care Explorations 2021, 3: e0572. PMID: 34746797, PMCID: PMC8565795, DOI: 10.1097/cce.0000000000000572.
- Grunauer M, Mikesell C, Bustamante G, Cobo G, Sánchez S, Román A, Icaza-Freire A, Gavilanes A, Wang N, Group T, González J, López-Herce J, Rossetti E, Fabrizio C, Karam O, Saint-Faust M, Biban P, Carlassara S, von Dessauer B, Ordenes N, Urízar F, A A, Canarie M, Miller K, Irazuzta J, Chiriboga N, Tawfik D, Sourkes B, Wang N, Vongsachang H, Tucker E, Shilkofski N, Wang 王, Wenchao R, Yuxia Z, See L, Priscilla, Tekin R, Aktar F, Düzkaya D, Dursun O, Ongun E, Yilmaz R, Yildizdas D, Tekgüç H, Sazonov V, Tsoy T, Sazonov V, Saparov A, Sazonov V, Kalmbakh E, Grunauer M, Eguiguren L, Claudette K, Tovilla Y, Gómez S, Torres S, Cobarrubias P, Dmytriiev D, Martínez A, Guzaman G, Sanabria R, Krupanandan R, Ramachandran B, Choraria N, Patel J, Pooni P, Gill K, Appiah J, Anokye K, Heye T, Argaw R, Demtse A, Admasu I. Pain Assessment and Management in Pediatric Intensive Care Units Around the World, an International, Multicenter Study. Frontiers In Pediatrics 2021, 9: 746489. PMID: 34778135, PMCID: PMC8581242, DOI: 10.3389/fped.2021.746489.
- Goel R, Nellis ME, Karam O, Hanson SJ, Tormey CA, Patel RM, Birch R, Sachais BS, Sola‐Visner M, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Study‐IV‐Pediatric F. Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III). Transfusion 2021, 61: 2589-2600. PMID: 34455598, DOI: 10.1111/trf.16626.
- Sequeira J, Nellis ME, Karam O. Epidemiology of Bleeding in Critically Ill Children. Frontiers In Pediatrics 2021, 9: 699991. PMID: 34422724, PMCID: PMC8371326, DOI: 10.3389/fped.2021.699991.
- Hanson SJ, Karam O, Birch R, Goel R, Patel RM, Sola-Visner M, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Nellis ME, Lung A. Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database. Pediatric Critical Care Medicine 2021, 22: 978-987. PMID: 34261944, PMCID: PMC8570986, DOI: 10.1097/pcc.0000000000002805.
- Crighton GL, Karam O, Nellis ME, Stanworth SJ. Editorial: Hemostatic Challenges in Pediatric Critical Care Medicine. Frontiers In Pediatrics 2021, 9: 697921. PMID: 34322464, PMCID: PMC8311020, DOI: 10.3389/fped.2021.697921.
- Chegondi M, Vijayakumar N, Billa R, Badheka A, Karam O. Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children. Journal Of Pediatric Intensive Care 2021, 12: 228-234. PMID: 37565022, PMCID: PMC10411082, DOI: 10.1055/s-0041-1731434.
- Nguyen DA, De Mul A, Hoskote AU, Cogo P, da Cruz EM, Erickson S, Lasa JJ, Thiagarajan RR, Bembea MM, Karam O, ESPNIC A. Factors Associated With Initiation of Extracorporeal Cardiopulmonary Resuscitation in the Pediatric Population: An International Survey. ASAIO Journal 2021, 68: 413-418. PMID: 34074851, DOI: 10.1097/mat.0000000000001495.
- Nellis ME, Goel R, Hendrickson JE, Birch R, Patel RM, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Sola‐Visner M, Josephson CD, Karam O, Study‐IV‐Pediatric F. Transfusion practices in a large cohort of hospitalized children. Transfusion 2021, 61: 2042-2053. PMID: 33973660, DOI: 10.1111/trf.16443.
- Nellis ME, Vasovic LV, Goel R, Karam O. Epidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study. Frontiers In Pediatrics 2021, 9: 673613. PMID: 34041211, PMCID: PMC8141845, DOI: 10.3389/fped.2021.673613.
- Karsies T, Tarquinio K, Shein SL, Beardsley AL, Prentice E, Karam O, Fontela P, Moore-Clingenpeel M, Willson DF. Compliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated INfection (VAIN2) Study*. Pediatric Critical Care Medicine 2021, 22: 859-869. PMID: 33965989, DOI: 10.1097/pcc.0000000000002761.
- Patel RM, Hendrickson JE, Nellis ME, Birch R, Goel R, Karam O, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Sola-Visner M, National Heart L, Mast A, Hod E, Custer B, Vichinsky E, Spencer B, Mathew S, Harris D, Busch M, Norris P, Ness P, Kleinman S, Tamburro R, Glynn S, Malkin K. Variation in Neonatal Transfusion Practice. The Journal Of Pediatrics 2021, 235: 92-99.e4. PMID: 33836184, PMCID: PMC8316298, DOI: 10.1016/j.jpeds.2021.04.002.
- Schapka E, Gee J, Cyrus JW, Goldstein G, Greenfield K, Marinello M, Karam O. Lung Ultrasound versus Chest X-Ray for the Detection of Fluid Overload in Critically Ill Children: A Systematic Review. Journal Of Pediatric Intensive Care 2021, 11: 177-182. PMID: 35928036, PMCID: PMC9345674, DOI: 10.1055/s-0041-1725123.
- Barbateskovic M, Koster TM, Eck RJ, Maagaard M, Afshari A, Blokzijl F, Cronhjort M, Dieperink W, Fabritius ML, Feinberg J, French C, Gareb B, Geisler A, Granholm A, Hiemstra B, Hu R, Imberger G, Jensen BT, Jonsson AB, Karam O, Kong Z, Korang SK, Koster G, Lai B, Liang N, Lundstrøm LH, Marker S, Meyhoff TS, Nielsen EE, Nørskov AK, Munch MW, Risom EC, Rygård SL, Safi S, Sethi N, Sjövall F, Lauridsen SV, van Bakelen N, Volbeda M, van der Horst ICC, Gluud C, Perner A, Møller MH, Keus E, Wetterslev J. A new tool to assess Clinical Diversity In Meta‐analyses (CDIM) of interventions. Journal Of Clinical Epidemiology 2021, 135: 29-41. PMID: 33561529, DOI: 10.1016/j.jclinepi.2021.01.023.
- Aran AA, Karam O, Nellis ME. Bleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation. Frontiers In Pediatrics 2021, 9: 611680. PMID: 33585373, PMCID: PMC7873638, DOI: 10.3389/fped.2021.611680.
- Karam O, Nellis ME. Transfusion management for children supported by extracorporeal membrane oxygenation. Transfusion 2021, 61: 660-664. PMID: 33491189, DOI: 10.1111/trf.16272.
- Dengler B, Karam O, Barthol C, Hafeez S. Ketamine Boluses Decrease Intracranial Pressure and Improve Cerebral Perfusion Pressure in Patients with Severe Traumatic Brain Injury. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_450.
- Kahn S, Chegondi M, Nellis ME, Karam O. Overview of Plasma and Platelet Transfusions in Critically Ill Children. Frontiers In Pediatrics 2020, 8: 601659. PMID: 33282804, PMCID: PMC7691248, DOI: 10.3389/fped.2020.601659.
- Greenfield KD, Karam O, O'Meara A. Brighter Days May Be Ahead: Continuous Measurement of Pediatric Intensive Care Unit Light and Sound. Frontiers In Pediatrics 2020, 8: 590715. PMID: 33194924, PMCID: PMC7649178, DOI: 10.3389/fped.2020.590715.
- Nellis ME, Spinella PC, Tucci M, Stanworth SJ, Steiner ME, Cushing MM, Davis PJ, Karam O, The Pediatric Acute Lung Injury and Sepsis Investigators network P. Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children. Transfusion 2020, 60: 2849-2858. PMID: 32959409, PMCID: PMC8396066, DOI: 10.1111/trf.16094.
- Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion 2020, 36: 501-512. PMID: 32862767, PMCID: PMC8216320, DOI: 10.1177/0267659120952982.
- Demaret P, Karam O. Designing Appropriate and Individualized Transfusion Strategies: Finding the Sweet Spot. Pediatric Critical Care Medicine 2020, 21: 770-772. PMID: 32769943, DOI: 10.1097/pcc.0000000000002369.
- Biboulet P, Motais C, Pencole M, Karam O, Dangelser G, Smilevitch P, Maissiat G, Capdevila X, Bringuier S. Preoperative erythropoietin within a patient blood management program decreases both blood transfusion and postoperative anemia: a prospective observational study. Transfusion 2020, 60: 1732-1740. PMID: 32681743, DOI: 10.1111/trf.15900.
- Greenfield K, Karam O, O'Meara A. Are Brighter Days Ahead? Light and Sound in the Pediatric Intensive Care Unit. 2020, 146: 161-162. DOI: 10.1542/peds.146.1ma2.161.
- Goel R, Josephson CD, Patel EU, Petersen MR, Packman Z, Gehrie E, Bloch EM, Lokhandwala P, Ness PM, Katz L, Nellis M, Karam O, Tobian AAR. Individual‐ and hospital‐level correlates of red blood cell, platelet, and plasma transfusions among hospitalized children and neonates: a nationally representative study in the United States. Transfusion 2020, 60: 1700-1712. PMID: 32589286, PMCID: PMC7951993, DOI: 10.1111/trf.15855.
- Klee P, Rimensberger PC, Karam O. Association Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass. Frontiers In Pediatrics 2020, 8: 332. PMID: 32656170, PMCID: PMC7325592, DOI: 10.3389/fped.2020.00332.
- Karam O, Goel R, Dalton H, Nellis ME. Epidemiology of Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation. Critical Care Medicine 2020, 48: e698-e705. PMID: 32697511, DOI: 10.1097/ccm.0000000000004417.
- Hughes A, Carter K, Cyrus J, Karam O. Pleural Effusions After Congenital Cardiac Surgery Requiring Readmission: A Systematic Review and Meta-analysis. Pediatric Cardiology 2020, 41: 1145-1152. PMID: 32424719, DOI: 10.1007/s00246-020-02365-4.
- Karam O, Goel R, Dalton H, Nellis M. Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation. 2020, a1742-a1742. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1742.
- Karam O, Klee P, Rimensberger P. Association Between Lactates, Blood Glucose, and Oxygen Extraction in Critically Ill Children After Cardiopulmonary Bypass. 2020, a6311-a6311. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6311.
- Iqbal O'Meara AM, Miller Ferguson N, Zven SE, Karam OL, Meyer LC, Bigbee JW, Sato-Bigbee C. Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats. Critical Care Explorations 2020, 2: e0105. PMID: 32426747, PMCID: PMC7188419, DOI: 10.1097/cce.0000000000000105.
- Goel R, Josephson CD, Patel EU, Petersen MR, Makhani S, Frank SM, Ness PM, Bloch EM, Gehrie EA, Lokhandwala PM, Nellis MM, Karam O, Shaz BH, Patel RM, Tobian AAR. Perioperative Transfusions and Venous Thromboembolism. 2020, 145: e20192351. PMID: 32198293, PMCID: PMC7111487, DOI: 10.1542/peds.2019-2351.
- Demaret P, Karam O, Labreuche Bst J, Chiusolo F, Mayordomo Colunga J, Erickson S, Nellis ME, Perez MH, Ray S, Tucci M, Willems A, Duhamel A, Lebrun F, Loeckx I, Mulder A, Leteurtre S. How 217 Pediatric Intensivists Manage Anemia at PICU Discharge: Online Responses to an International Survey. Pediatric Critical Care Medicine 2020, 21: e342-e353. PMID: 32217901, DOI: 10.1097/pcc.0000000000002307.
- Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatric Critical Care Medicine 2020, 21: 267-275. PMID: 31644453, PMCID: PMC7060816, DOI: 10.1097/pcc.0000000000002160.
- Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine 2020, 46: 10-67. PMID: 32030529, PMCID: PMC7095013, DOI: 10.1007/s00134-019-05878-6.
- Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine 2020, 46: 1-9. PMID: 32030528, DOI: 10.1007/s00134-019-05877-7.
- Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine 2020, 21: 186-195. PMID: 32032264, DOI: 10.1097/pcc.0000000000002197.
- Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine 2020, 21: e52-e106. PMID: 32032273, DOI: 10.1097/pcc.0000000000002198.
- Nellis ME, Tucci M, Lacroix J, Spinella PC, Haque KD, Stock A, Steiner ME, Faustino EVS, Zantek ND, Davis PJ, Stanworth SJ, Cholette JM, Parker RI, Demaret P, Kneyber MCJ, Russell RT, Stricker PA, Vogel AM, Willems A, Josephson CD, Luban NLC, Loftis LL, Leteurtre S, Stocker CF, Goobie SM, Karam O. Bleeding Assessment Scale in Critically Ill Children (BASIC): Physician-Driven Diagnostic Criteria for Bleeding Severity. Critical Care Medicine 2019, 47: 1766-1772. PMID: 31567407, PMCID: PMC6861687, DOI: 10.1097/ccm.0000000000004025.
- Nellis ME, Dalton H, Karam O. Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome. Critical Care Medicine 2019, 47: e886-e892. PMID: 31449061, PMCID: PMC8608374, DOI: 10.1097/ccm.0000000000003968.
- François T, Emeriaud G, Karam O, Tucci M. Transfusion in children with acute respiratory distress syndrome. Annals Of Translational Medicine 2019, 7: 511. PMID: 31728364, PMCID: PMC6828792, DOI: 10.21037/atm.2019.08.28.
- Demaret P, Valla FV, Behal H, Mimouni Y, Baudelet JB, Karam O, Recher M, Duhamel A, Tucci M, Javouhey E, Leteurtre S. Anemia at Discharge From the PICU: A Bicenter Descriptive Study. Pediatric Critical Care Medicine 2019, 20: e400-e409. PMID: 31246740, DOI: 10.1097/pcc.0000000000002015.
- Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections.Shein SL, Karam O, Beardsley A, Karsies T, Prentice E, Tarquinio KM, Willson DF. Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections. Pediatric Critical Care Medicine 2019, 20: 697-706. PMID: 30985606, DOI: 10.1097/pcc.0000000000001942.
- Doell C, De Mul A, Nguyen DA, Perez MH, Karam O, Cannizzaro V. Reply to: Prognostic Evaluation of Mortality after Pediatric Resuscitation Assisted by Extracorporeal Life Support. Journal Of Pediatric Intensive Care 2019, 08: 193-194. PMID: 31404921, PMCID: PMC6687445, DOI: 10.1055/s-0039-1692969.
- Nellis ME, Goel R, Karam O. Transfusion Management in Pediatric Oncology Patients. Hematology/Oncology Clinics Of North America 2019, 33: 903-913. PMID: 31466612, DOI: 10.1016/j.hoc.2019.05.011.
- Nellis ME, Levasseur J, Stribling J, Faustino EVS, Zantek ND, Sheth S, Karam O. Bleeding Scales Applicable to Critically Ill Children: A Systematic Review. Pediatric Critical Care Medicine 2019, 20: 603-607. PMID: 30925573, DOI: 10.1097/pcc.0000000000001943.
- Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis. Pediatric Critical Care Medicine 2019, 20: e342-e351. PMID: 31107379, DOI: 10.1097/pcc.0000000000001987.
- Karam O, Nellis ME, Zantek ND, Lacroix J, Faustino EVS. Criteria for Clinically Relevant Bleeding in Critically Ill Children. Pediatric Critical Care Medicine 2019, Publish Ahead of Print: &na;. PMID: 30575698, DOI: 10.1097/pcc.0000000000001828.
- Buyck M, Manzano S, Haddad K, Moncousin AC, Galetto-Lacour A, Blondon K, Karam O. Effects of Blindfold on Leadership in Pediatric Resuscitation Simulation: A Randomized Trial. Frontiers In Pediatrics 2019, 7: 10. PMID: 30838188, PMCID: PMC6383074, DOI: 10.3389/fped.2019.00010.
- Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Effects of ABO Matching of Platelet Transfusions in Critically Ill Children*. Pediatric Critical Care Medicine 2019, 20: e61-e69. PMID: 30422914, PMCID: PMC6709973, DOI: 10.1097/pcc.0000000000001779.
- Calinescu AM, Karam O, Wilde JCH, Ansari M, McLin VA, Wildhaber BE. International survey on anticoagulation and antiplatelet strategies after pediatric liver transplantation. Pediatric Transplantation 2018, 23: e13317. PMID: 30393923, DOI: 10.1111/petr.13317.
- Keir AK, Karam O, Hodyl N, Stark MJ, Liley HG, Shah PS, Stanworth SJ, Group O. International, multicentre, observational study of fluid bolus therapy in neonates. Journal Of Paediatrics And Child Health 2018, 55: 632-639. PMID: 30328174, DOI: 10.1111/jpc.14260.
- Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatric Critical Care Medicine 2018, 19: 884-898. PMID: 30180125, PMCID: PMC6126913, DOI: 10.1097/pcc.0000000000001613.
- Karam O, Russell RT, Stricker P, Vogel AM, Bateman ST, Valentine SL, Spinella PC. Recommendations on RBC Transfusion in Critically Ill Children With Nonlife-Threatening Bleeding or Hemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatric Critical Care Medicine 2018, 19: s127-s132. PMID: 30161067, PMCID: PMC6121734, DOI: 10.1097/pcc.0000000000001605.
- Nellis ME, Karam O, Mauer E, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Platelet Transfusion Practices in Critically Ill Children. Critical Care Medicine 2018, 46: 1309-1317. PMID: 29727368, PMCID: PMC6476545, DOI: 10.1097/ccm.0000000000003192.
- De Mul A, Nguyen DA, Doell C, Perez MH, Cannizzaro V, Karam O. Prognostic Evaluation of Mortality after Pediatric Resuscitation Assisted by Extracorporeal Life Support. Journal Of Pediatric Intensive Care 2018, 08: 057-063. PMID: 31093456, PMCID: PMC6517051, DOI: 10.1055/s-0038-1667012.
- Arni D, Wildhaber BE, McLin V, Rimensberger PC, Ansari M, Fontana P, Karam O. Effects of plasma transfusions on antithrombin levels after paediatric liver transplantation. Vox Sanguinis 2018, 113: 569-576. PMID: 29761839, DOI: 10.1111/vox.12664.
- Nellis ME, Karam O. Assessing our current practice: point prevalence studies in transfusion medicine. Transfusion 2018, 58: 843-845. PMID: 29380394, DOI: 10.1111/trf.14492.
- Janaillac M, Beausoleil TP, Barrington KJ, Raboisson MJ, Karam O, Dehaes M, Lapointe A. Correlations between near-infrared spectroscopy, perfusion index, and cardiac outputs in extremely preterm infants in the first 72 h of life. European Journal Of Pediatrics 2018, 177: 541-550. PMID: 29374830, DOI: 10.1007/s00431-018-3096-z.
- Broccolo M, Favez N, Karam O. Perceived changes in behavior and values after a red blood cell transfusion. International Journal Of Clinical Transfusion Medicine 2017, 6: 1-5. DOI: 10.2147/ijctm.s155338.
- Valpacos M, Arni D, Keir A, Aspirot A, Wilde JCH, Beasley S, De Luca D, Pfister RE, Karam O. Diagnosis and Management of Necrotizing Enterocolitis: An International Survey of Neonatologists and Pediatric Surgeons. Neonatology 2017, 113: 170-176. PMID: 29241163, DOI: 10.1159/000484197.
- Demaret P, Karam O, Tucci M, Lacroix J, Behal H, Duhamel A, Lebrun F, Mulder A, Leteurtre S. Anemia at pediatric intensive care unit discharge: prevalence and risk markers. Annals Of Intensive Care 2017, 7: 107. PMID: 29067568, PMCID: PMC5655401, DOI: 10.1186/s13613-017-0328-8.
- Zellweger A, Eckert P, Karam O, Cedraschi C, Moretti D, Majmou H, Carre D, Ludwig V, Gasche Y. A Quantitative Pilot Study on Donation after Cardiac Death (DCD). Transplantation 2017, 101: s21. DOI: 10.1097/01.tp.0000525002.75001.e9.
- Camazine MN, Karam O, Colvin R, Leteurtre S, Demaret P, Tucci M, Muszynski JA, Stanworth S, Spinella PC. Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*. Pediatric Critical Care Medicine 2017, 18: e215-e223. PMID: 28350560, DOI: 10.1097/pcc.0000000000001149.
- Delcò C, Karam O, Pfister R, Gervaix A, Renzi G, Emonet S, Schrenzel J, Posfay-Barbe KM. Rapid detection and ruling out of neonatal sepsis by PCR coupled with Electrospray Ionization Mass Spectrometry (PCR/ESI-MS). Early Human Development 2017, 108: 17-22. PMID: 28343091, DOI: 10.1016/j.earlhumdev.2017.03.004.
- Factors influencing plasma transfusion practices in paediatric intensive care units around the worldKaram O, Demaret P, Duhamel A, Shefler A, Spinella PC, Tucci M, Leteurtre S, Stanworth SJ, investigators T. Factors influencing plasma transfusion practices in paediatric intensive care units around the world. Vox Sanguinis 2017, 112: 140-149. PMID: 28176380, DOI: 10.1111/vox.12490.
- Sternberg J, Pfister R, Karam O. Hypoglycemic relapse in term infants treated with glucose infusion. Journal Of Clinical Neonatology 2017, 6: 163-167. DOI: 10.4103/jcn.jcn_10_17.
- Karam O, Gebistorf F, Wetterslev J, Afshari A. The effect of inhaled nitric oxide in acute respiratory distress syndrome in children and adults: a Cochrane Systematic Review with trial sequential analysis. Anaesthesia 2016, 72: 106-117. PMID: 27762438, DOI: 10.1111/anae.13628.
- Bragard I, Farhat N, Seghaye MC, Karam O, Neuschwander A, Shayan Y, Schumacher K. Effectiveness of a High-Fidelity Simulation-Based Training Program in Managing Cardiac Arrhythmias in Children: A Randomized Pilot Study. Pediatric Emergency Care 2016, 35: 412-418. PMID: 27763955, DOI: 10.1097/pec.0000000000000931.
- Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Stanworth SJ, Tucci M, Leteurtre S, for the PlasmaTV investigators. Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions. Annals Of Intensive Care 2016, 6: 98. PMID: 27714707, PMCID: PMC5053948, DOI: 10.1186/s13613-016-0197-6.
- Arni D, Karam O, Vidal I, Rimensberger PC, Hanquinet S, Wildhaber BE. Are Scores Reliable in Predicting the Need for Surgery and Mortality in Necrotizing Enterocolitis? European Journal Of Pediatric Surgery 2016, 27: 330-335. PMID: 27706524, DOI: 10.1055/s-0036-1593382.
- Pregernig A, Karam O. Potential Pediatric Organ Donors After Cardiac Death. Transplantation Proceedings 2016, 48: 2588-2591. PMID: 27788786, DOI: 10.1016/j.transproceed.2016.06.049.
- Klee P, Arni D, Saudan S, Schwitzgebel VM, Sharma R, Karam O, Rimensberger PC. Ketosis After Cardiopulmonary Bypass in Children Is Associated With an Inadequate Balance Between Oxygen Transport and Consumption*. Pediatric Critical Care Medicine 2016, 17: 852-859. PMID: 27472253, DOI: 10.1097/pcc.0000000000000880.
- Gebistorf F, Karam O, Wetterslev J, Afshari A. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults. Cochrane Database Of Systematic Reviews 2016, 2018: cd002787. PMID: 27347773, PMCID: PMC6464789, DOI: 10.1002/14651858.cd002787.pub3.
- Janaillac M, Labarinas S, Pfister RE, Karam O. Accuracy of Transcutaneous Carbon Dioxide Measurement in Premature Infants. Critical Care Research And Practice 2016, 2016: 8041967. PMID: 27375901, PMCID: PMC4916268, DOI: 10.1155/2016/8041967.
- Karam O, Tucci M. Massive Transfusion in Children. Transfusion Medicine Reviews 2016, 30: 213-216. PMID: 27287298, DOI: 10.1016/j.tmrv.2016.05.010.
- Brunner A, Dubois N, Rimensberger PC, Karam O. Identifying Prognostic Criteria for Survival after Resuscitation Assisted by Extracorporeal Membrane Oxygenation. Critical Care Research And Practice 2016, 2016: 9521091. PMID: 27006826, PMCID: PMC4781941, DOI: 10.1155/2016/9521091.
- Hagerman A, Karam O. Molecular Adsorbent Recirculating System (MARS™ en réanimation pédiatrique. Médecine Intensive Réanimation 2016, 25: 239-245. DOI: 10.1007/s13546-015-1162-3.
- Karam O, Pregernig A. Donneurs d’organes potentiels aux soins intensifs pédiatriques. 2016, 9 DOI: 10.24894/bf.2016.09005.
- Delco-Volonte C, Posfay-Barbe K, Karam O. Rapid diagnosis to rule out bacterial bloodstream infection in neonates. Intensive Care Medicine Experimental 2015, 3: a298. PMCID: PMC4798179, DOI: 10.1186/2197-425x-3-s1-a298.
- Demaret P, Tucci M, Karam O, Trottier H, Ducruet T, Lacroix J. Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 505-514. PMID: 25905491, DOI: 10.1097/pcc.0000000000000423.
- Karam O, Demaret P, Shefler A, Leteurtre S, Spinella PC, Stanworth SJ, Tucci M. Indications and Effects of Plasma Transfusions in Critically Ill Children. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 1395-1402. PMID: 25859890, DOI: 10.1164/rccm.201503-0450oc.
- Try A, Karam O, Delcò C, Kraemer K, Boulvain M, Pfister RE. Moderate and extended neonatal resuscitations occur in one in 10 births and require specialist cover 24 hours a day. Acta Paediatrica 2015, 104: 589-595. PMID: 25619977, DOI: 10.1111/apa.12909.
- Karam O, Tucci M. Primum Non Nocere*. Pediatric Critical Care Medicine 2015, 16: 189-190. PMID: 25647127, DOI: 10.1097/pcc.0000000000000326.
- Grazioli S, Karam O, Rimensberger PC. New Generation Neonatal High Frequency Ventilators: Effect of Oscillatory Frequency and Working Principles on Performance. Respiratory Care 2014, 60: 363-370. PMID: 25406342, DOI: 10.4187/respcare.03048.
- Labarinas S, Arni D, Karam O. Transfusions de plasma en réanimation pédiatrique. Médecine Intensive Réanimation 2014, 23: 455-462. DOI: 10.1007/s13546-014-0900-2.
- Karam O, Tucci M, Combescure C, Lacroix J, Rimensberger PC. Plasma transfusion strategies for critically ill patients. Cochrane Database Of Systematic Reviews 2013, 2013: cd010654. PMID: 24374651, PMCID: PMC12001317, DOI: 10.1002/14651858.cd010654.pub2.
- Shayan Y, Gravel J, Bhanji F, Weiss M, Karam O, Manzano S, Bank I, Choker G, Levy A. Board 424 - Research Abstract Validation of a Tool for the Assessment of Trainees During Simulated Pediatric Resuscitation (Submission #967). Simulation In Healthcare The Journal Of The Society For Simulation In Healthcare 2013, 8: 593. DOI: 10.1097/01.sih.0000441676.11945.49.
- Vignaux L, Grazioli S, Piquilloud L, Bochaton N, Karam O, Levy-Jamet Y, Jaecklin T, Tourneux P, Jolliet P, Rimensberger PC. Patient–Ventilator Asynchrony During Noninvasive Pressure Support Ventilation and Neurally Adjusted Ventilatory Assist in Infants and Children. Pediatric Critical Care Medicine 2013, 14: e357-e364. PMID: 23863816, DOI: 10.1097/pcc.0b013e3182917922.
- Vignaux L, Grazioli S, Piquilloud L, Bochaton N, Karam O, Jaecklin T, Levy-Jamet Y, Tourneux P, Jolliet P, Rimensberger PC. Optimizing Patient-Ventilator Synchrony During Invasive Ventilator Assist in Children and Infants Remains a Difficult Task*. Pediatric Critical Care Medicine 2013, 14: e316-e325. PMID: 23842584, DOI: 10.1097/pcc.0b013e31828a8606.
- Karam O, Tucci M, Lacroix J, Rimensberger PC, Network C. International survey on plasma transfusion practices in critically ill children. Transfusion 2013, 54: 1125-1132. PMID: 24032693, DOI: 10.1111/trf.12393.
- Karam O, Tucci M, Combescure C, Lacroix J, Rimensberger P. Plasma transfusion strategies for critically ill patients. 2013 DOI: 10.1002/14651858.cd010654.
- Labarinas S, Arni D, Karam O. Plasma in the PICU: why and when should we transfuse? Annals Of Intensive Care 2013, 3: 16. PMID: 23725411, PMCID: PMC3698065, DOI: 10.1186/2110-5820-3-16.
- Karam O, Lacroix J, Robitaille N, Rimensberger PC, Tucci M. Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study. Vox Sanguinis 2013, 104: 342-349. PMID: 23294337, DOI: 10.1111/vox.12009.
- Karam O, Tucci M, Ducruet T, Hume H, Lacroix J, Gauvin F. Mortality associated with restrictive threshold for red blood cell transfusion in pediatric patients with sepsis. Pediatric Critical Care Medicine 2012, 13: 495. DOI: 10.1097/pcc.0b013e31824fbefe.
- Karam O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F. Red blood cell transfusion thresholds in pediatric patients with sepsis*. Pediatric Critical Care Medicine 2011, 12: 512-518. PMID: 21057356, DOI: 10.1097/pcc.0b013e3181fe344b.
- Karam O, Tucci M, Ducruet T, Hume H, Lacroix J, Gauvin F. Red blood cell transfusion thresholds in pediatric septic patients. Critical Care 2011, 15: p428. PMCID: PMC3068357, DOI: 10.1186/cc9848.
- Karam O, Roy M, Barrington K, Janvier A. Long-distance air transport of an infant weighing less than 500 g: Is it in the patient’s best interest? Paediatrics & Child Health 2011, 16: 79-81. PMID: 22294866, PMCID: PMC3043038, DOI: 10.1093/pch/16.2.79.
- Lacroix J, Tucci M, Tinmouth A, Gauvin F, Karam O. Chapter 82 Transfusion Medicine. 2011, 1162-1176. DOI: 10.1016/b978-0-323-07307-3.10082-5.
- Karam O, Sanchez O, Wildhaber B, La Scala G. National Survey on Abdominal Trauma Practices of Pediatric Surgeons. European Journal Of Pediatric Surgery 2010, 20: 334-338. PMID: 20976655, DOI: 10.1055/s-0030-1261885.
- Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, Hébert PC, Hutchison JS, Hume HA, Tucci M, Network O. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion 2010, 50: 1902-1913. PMID: 20456697, DOI: 10.1111/j.1537-2995.2010.02661.x.
- Karam O, Tucci M, Bateman ST, Ducruet T, Spinella PC, Randolph AG, Lacroix J. Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study. Critical Care 2010, 14: r57. PMID: 20377853, PMCID: PMC2887178, DOI: 10.1186/cc8953.
- Karam O, Tucci M, Toledano BJ, Robitaille N, Cousineau J, Thibault L, Lacroix J, Le Deist F. Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion 2009, 49: 2326-2334. PMID: 19624600, DOI: 10.1111/j.1537-2995.2009.02319.x.
- Karam O, Sanchez O, Wildhaber B, Chardot C, La Scala G. Blunt abdominal trauma in children: a score to predict the absence of organ injury. Critical Care 2009, 13: p421. PMCID: PMC4084307, DOI: 10.1186/cc7585.
- Karam O, Tucci M, Bateman S, Ducruet T, Spinella P, Randolph A, Lacroix J. Effect of length of storage of red blood cell units on outcome in critically ill children. Critical Care 2009, 13: p417. PMCID: PMC4084303, DOI: 10.1186/cc7581.
- Karam O, Sanchez O, Chardot C, La Scala G. Blunt Abdominal Trauma in Children: A Score to Predict the Absence of Organ Injury. The Journal Of Pediatrics 2009, 154: 912-917. PMID: 19230903, DOI: 10.1016/j.jpeds.2009.01.001.
- Karam O, Donatiello C, Van Lancker E, Chritin V, Pfister RE, Rimensberger PC. Noise levels during nCPAP are flow-dependent but not device-dependent. Archives Of Disease In Childhood Fetal & Neonatal 2007, 93: f132-f134. PMID: 18089628, DOI: 10.1136/adc.2007.129098.
- Karam O, da Cruz E, Rimensberger PC. VGAM induced high-flow congestive heart failure responsive to PGE1 infusion. International Journal Of Cardiology 2007, 132: e60-e62. PMID: 18022260, DOI: 10.1016/j.ijcard.2007.08.020.
- Bottani A, Orrico A, Galli L, Karam O, Haenggeli CA, Ferey S, Conrad B. Unilateral focal polymicrogyria in a patient with classical Aarskog-Scott syndrome due to a novel missense mutation in an evolutionary conserved RhoGEF domain of the faciogenital dysplasia gene FGD1. American Journal Of Medical Genetics. Part A 2007, 143A: 2334-8. PMID: 17847065, DOI: 10.1002/ajmg.a.31733.
- * O, La Scala * G, Le Coultre C, Chardot C. Liver Function Tests in Children with Blunt Abdominal Traumas. European Journal Of Pediatric Surgery 2007, 17: 313-316. PMID: 17968786, DOI: 10.1055/s-2007-965533.
- Karam O, Pfister RE, Extermann P, La Scala GC. Congenital lingual cysts. Journal Of Pediatric Surgery 2007, 42: e25-e27. PMID: 17448749, DOI: 10.1016/j.jpedsurg.2007.01.060.
Departments and Programs
Biography
Oliver Karam, MD, PhD, specializes in pediatric critical care medicine. He diagnoses and treats severe health issues in critically ill children and manages life-threatening conditions using advanced life support systems, as well as addressing common complications such as bleeding and thrombosis (severe blood clots that block normal blood flow).
As a professor of pediatrics at Yale School of Medicine, Dr. Karam conducts research on blood transfusion strategies in critically ill children. He aims to improve outcomes by refining definitions and treatment protocols for bleeding and thrombotic complications. He also explores the use of extracorporeal membrane oxygenation (ECMO, a form of advanced, short-term life support for patients with heart or lung failure) and analyzes its psychological impacts on parents, guiding efforts to enhance family support.
“What drew me to pediatric critical care is the combination of treating very sick children and seeing how quickly many of them recover,” Dr. Karam says. “In the pediatric intensive care unit, we often care for children at their most critical moment, yet with the right care and teamwork, the vast majority improve and are able to go home to their families.”
Dr. Karam also values the opportunity to work on research that can improve care for critically ill children: “The goal is not only to help the patients we treat today, but also to develop evidence that can improve outcomes for the millions of children who require intensive care around the world each year.”
Dr. Karam received his medical degree from the University of Geneva in Switzerland, where he also completed a residency in pediatrics, and then pursued fellowship in pediatric critical care medicine at the University of Montreal. He received his doctoral degree in clinical research at the University of Lille in France.
Titles
- Professor of Pediatrics (Critical Care Medicine)
- Chief of Pediatric Critical Care, Pediatrics
Education & Training
- FellowshipUniversity of Geneva (2021)
- FellowshipUniversity of Montreal (2021)
- PhDUniversity of Lille (2017)
- MScUniversity of Montreal (2011)
- FellowshipSainte Justine Hospital (2010)
- ResidentGeneva University Hospital (2007)
- MDUniversity of Geneva (2002)
Languages Spoken
- English
- Français (French)
Additional Information
Publications
- Hendrickson J, Birch R, Sola-Visner M, Branchford B, Chen X, Custer B, Desimone R, Bougie D, Edwards E, Goel R, Gottschall J, Hod E, Moayeri M, Roubinian N, Karam O, Stone E, Luban N, Josephson C, Patel R. International classification of diseases codes have low positive predictive value for neonatal morbidities. Journal Of Perinatology 2025, 1-2. PMID: 41310310, PMCID: PMC12716811, DOI: 10.1038/s41372-025-02470-3.
- Calamusa J, Karam O, Li W, Labarinas S. Avoiding unnecessary massive transfusion protocol activation in paediatric trauma: Development of the activation of massive transfusion in children score. Vox Sanguinis 2025 PMID: 41253356, DOI: 10.1111/vox.70154.
- Labarinas S, Norbisrath K, Nnaemeka I, Bai Y, Tint H, Johnson D, Brady K, Karam O. Plasma Exchange in the Setting of Immune‐Mediated Multiple Organ Failure in the Cardiac ICU During ECMO: A Case Series. Journal Of Clinical Apheresis 2025, 40: e70061. PMID: 41046521, DOI: 10.1002/jca.70061.
- Patel R, Hendrickson J, Birch R, Bougie D, Branchford B, Chen X, Custer B, Desimone R, Edwards E, Goel R, Gottschall J, Hod E, Moayeri M, Karam O, Stone E, Luban N, Josephson C, Sola-Visner M, Study-IV-Pediatric N. Temporal Trends in Red Blood Cell and Platelet Transfusion Thresholds for Extremely Low Birth Weight Infants. The Journal Of Pediatrics 2025, 288: 114797. PMID: 40887015, PMCID: PMC12533266, DOI: 10.1016/j.jpeds.2025.114797.
- Karam O, Atchison C, Chegondi M. Why Outcome Definition Precedes Risk of Bias Assessment in Extracorporeal Membrane Oxygenation Bleeding Research. ASAIO Journal 2025 PMID: 40747890, DOI: 10.1097/mat.0000000000002527.
- Labarinas S, Karam O. Transfusion Medicine in the Pediatric Intensive Care Unit. 2025, 643-656. DOI: 10.1007/978-3-031-64762-8_40.
- El Amin N, Karam O. Haemoglobinopathies and Haemostatic Disorders in the PICU. 2025, 627-641. DOI: 10.1007/978-3-031-64762-8_39.
- Hickey K, Smith M, Karam O, Demetres M, Faraoni D, Duron V, Wu Y, Nellis M. The Effect of Prophylactic Use of Antifibrinolytics During Pediatric Non‐Cardiac Surgeries on Bleeding and Transfusions: A Systematic Review and Meta‐Analysis. Pediatric Anesthesia 2025, 35: 668-683. PMID: 40476647, DOI: 10.1111/pan.15137.
- Atchison C, Chegondi M, Aldairi N, Carmona C, Mahmood H, Levasseur J, Funaro M, Faustino E, Nellis M, Willems A, Labarinas S, Karam O. Bleeding Definitions in Pediatric Extracorporeal Membrane Oxygenation (ECMO) Studies: A Systematic Review and Meta-Analysis. ASAIO Journal 2025 PMID: 40397688, DOI: 10.1097/mat.0000000000002468.
- Ingle T, Simms B, Bain J, Bembea M, Cholette J, Chegondi M, Cheung E, Niebler R, Ozment C, Paden M, Schiller O, Nellis M, Karam O. Platelet transfusion stated practices among neonatal and paediatric veno‐arterial extracorporeal membrane oxygenation providers: A survey. Vox Sanguinis 2025, 120: 597-604. PMID: 40097240, DOI: 10.1111/vox.70018.
- Demory A, Broden E, Equey L, Funaro M, Sharifi M, Harpaz-Rotem I, Traube C, Karam O. 123: TRAUMA-RELATED PSYCHOPATHOLOGIES AFTER EXTRACORPOREAL MEMBRANE OXYGENATION SUPPORT. Critical Care Medicine 2025, 53 DOI: 10.1097/01.ccm.0001099156.06691.67.
- Chegondi M, Jawahar A, Hrvojevic L, Karam O. 479: ASSOCIATION OF MEAN PLATELET VOLUME WITH BLEEDING AND CLOTTING RISKS ON ECMO. Critical Care Medicine 2025, 53 DOI: 10.1097/01.ccm.0001100580.64131.de.
- Atchison C, Chegondi M, Aldairi N, Carmona C, Mahmood H, Faustino E, Nellis M, Willems A, Labarinas S, Karam O. 525: BLEEDING DEFINITIONS IN EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) STUDIES. Critical Care Medicine 2025, 53 DOI: 10.1097/01.ccm.0001100764.36791.95.
- Demory A, Broden E, Equey L, Funaro M, Sharifi M, Harpaz-Rotem I, Traube C, Karam O, Organization I. Trauma-related psychopathologies after extracorporeal membrane oxygenation support: A systematic review and meta-analysis. Perfusion 2025, 40: 1546-1558. PMID: 39879146, DOI: 10.1177/02676591251317919.
- Carmona C, Bain J, Karam O. Concordance and discordance of anticoagulation assays in children supported by ECMO: The truth is out there. Perfusion 2024, 40: 1592-1599. PMID: 39719141, DOI: 10.1177/02676591241309841.
- Nellis M, Chegondi M, Willems A, Alqatani M, McMichael A, Aran A, Lerner R, Karam O, Investigators A. Assessing the Reliability of the Bleeding Assessment Scale in Critically Ill Children (BASIC) Definition: A Prospective Cohort Study. Pediatric Critical Care Medicine 2024, 26: e3-e11. PMID: 39560732, PMCID: PMC11774477, DOI: 10.1097/pcc.0000000000003638.
- Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Muszynski J. OP037 Topic: AS06–Extracorporeal Organ Support: ECMO/Ventricular Assist Devices (Temporary & Durable)/MARS/Total Plasma Exchange/Plasmapheresis/Other: PEDIATRIC EXTRACORPOREAL MEMBRANE OXYGENATION ANTICOAGULATION COLLABORATIVE (PEACE) CONSENSUS CONFERENCE. Pediatric Critical Care Medicine 2024, 25: e14-e14. DOI: 10.1097/01.pcc.0001084600.19979.1a.
- Johnson A, Szczepiorkowski Z, Balogun R, Karam O, Nellis M, Schneiderman J, Schwartz J, Winters J, Wu Y, Armendariz T, Burgstaler E, Collins L, Geile K, Pavenski K, Sanchez A, Witt V, Muthusamy A, Pederson T, Ramesh V, Thao M, Chlebeck T, Zantek N. Development of a Uniform Apheresis Case Report Form for Standardized Collection of Apheresis Data. Journal Of Clinical Apheresis 2024, 39: e22146. PMID: 39420527, PMCID: PMC11523286, DOI: 10.1002/jca.22146.
- Alexander P, Di Nardo M, Combes A, Vogel A, Antonini M, Barrett N, Benedetti G, Bettencourt A, Brodie D, Gómez-Gutiérrez R, Gorga S, Hodgson C, Kapoor P, Le J, MacLaren G, O’Neil E, Ostermann M, Paden M, Patel N, Rojas-Peña A, Said A, Sperotto F, Willems A, Vercaemst L, Yoganathan A, Lorts A, del Nido P, Barbaro R, Organization E, Network I, Investigators P, subgroup of PALISI and ELSO P, Care E, Group A, Society I, Society P, Network A, Consortium C, Association A, Surgeons S, Medicine S, Abecasis F, Al Foudri H, Anders M, Angus D, Annich G, Arachchillage D, Akcan-Arikan A, Armstrong A, Balcells J, Barrett M, Bartlett R, Belda-Hofheinz S, Bembea M, Best D, Bonadonna D, Boonstra P, Brogan T, Brown K, Butragueño-Laiseca L, Butt W, Camporota L, Cardenas B, Cascarano M, Caspi J, Chen E, Chiletti R, Colombo G, Conte M, Crowe L, Cvetkovic M, Dalton H, Daverio M, Davidson M, Davis C, DiGeronimo R, Egbunine A, Ellis W, Fan E, Foster C, Fraser J, Friedman M, Furlong-Dillard J, Fynn-Thompson F, Garcia A, Geppert J, Gillette N, Grazioli L, Greene C, Guerguerian A, Guilliams K, Fortis J, Hao J, Heinsar S, Hejduk M, Himebauch A, Horvat C, Hoskote A, Hou X, Hyslop R, Ibrahim N, Ito T, Karagiannidis C, Karam O, Kaushik S, Kilbaugh T, Kim-Campbell N, Kirsch R, Kormos R, Kornberger A, Krucoff M, Lakshminrusimha S, LaRovere K, Leger P, Levy P, Lorusso R, Lyster H, Malone M, McMullan D, Mečířová S, Mehran R, Merz S, Mochizuki S, Moler F, Molla K, Monagle P, Morgan G, Morgan C, Morice M, Muszynski J, Najaf T, Nellis M, Newburger J, O'Rourke P, Ostadal P, Ozment C, Pagani F, Peek G, Polito A, Priest J, Raman L, Rintoul N, Roy N, Rubin J, Rumford M, Rycus P, Ryerson L, Sakamoto W, Segura-Matute S, Shekar K, Spinella P, Spitzer E, Starr J, Stead C, Steffen K, Steiner M, Tan L, Tasker R, Taylor J, Thiagarajan R, Tonna J, Ubertini G, van Leeuwen G, Vang E, Ventetuolo C, Venugopal P, Weinberg A, Westrope C, Wu C, Wylie G, Zeymer U, Zivick E, Zochios V. Definitions of adverse events associated with extracorporeal membrane oxygenation in children: results of an international Delphi process from the ECMO-CENTRAL ARC. The Lancet Child & Adolescent Health 2024, 8: 773-780. PMID: 39299748, DOI: 10.1016/s2352-4642(24)00132-9.
- Hughes T, Treffalls R, Koek W, Dalton H, Karam O, Meyer A. Comprehensive secondary analysis of thrombotic events in pediatric patients receiving extracorporeal membrane oxygenation: A prospective cohort study. Perfusion 2024, 40: 1202-1209. PMID: 39352407, PMCID: PMC12202824, DOI: 10.1177/02676591241289358.
- Labarinas S, Norbisrath K, Johnson D, Brady K, Karam O. 196: Plasma exchange in the setting of immune-mediated multiple organ failure in the Cardiac ICU during ECMO, a case series. ASAIO Journal 2024, 70: 83-83. DOI: 10.1097/01.mat.0001070312.98485.e2.
- Karam O, Ahmed A, Bizzarro M, Bogue C, Giuliano J, Collaborative P, Al-Subu A, Bateman S, Berning E, Brown K, Bulut Y, Cheifetz I, Chegondi M, Cholette J, Cowl A, Ceneviva G, Gehlbach J, Hobson M, Kudchadkar S, Labarinas S, Louis C, Miller M, Marinello M, Malone M, Nair A, Nishisaki A, Lowrie L, Rehder K, Rozenfeld R, Schneider J, Sequeira J, Shein S, Stalets E, Taylor J, Yager P. Physical space of thirty pediatric intensive care units in the United States of America: a national survey. Frontiers In Pediatrics 2024, 12: 1473805. PMID: 39359742, PMCID: PMC11445063, DOI: 10.3389/fped.2024.1473805.
- Ozment C, Alexander P, Chandler W, Emani S, Hyslop R, Monagle P, Muszynski J, Willems A, Gehred A, Lyman E, Steffen K, Thiagarajan R, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman M, Muszynski J. Anticoagulation Monitoring and Targets: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e14-e24. PMID: 38959356, PMCID: PMC11216399, DOI: 10.1097/pcc.0000000000003494.
- Cashen K, Saini A, Brandão L, Le J, Monagle P, Moynihan K, Ryerson L, Gehred A, Lyman E, Muszynski J, Alexander P, Dalton H, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepall S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. Anticoagulant Medications: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e7-e13. PMID: 38959355, PMCID: PMC11216397, DOI: 10.1097/pcc.0000000000003495.
- Rintoul N, McMichael A, Bembea M, DiGeronimo R, Patregnani J, Alexander P, Muszynski J, Steffen K, Gehred A, Lyman E, Cheifetz I, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nico K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. Management of Bleeding and Thrombotic Complications During Pediatric Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e66-e77. PMID: 38959361, PMCID: PMC11216396, DOI: 10.1097/pcc.0000000000003489.
- Himebauch A, Priest J, Annich G, McMullan D, Turner D, Muszynski J, Alexander P, Paden M, Gehred A, Lyman E, Said A, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. The Influence of the Extracorporeal Membrane Oxygenation Circuit and Components on Anticoagulation Management: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e1-e6. PMID: 38959354, PMCID: PMC11216392, DOI: 10.1097/pcc.0000000000003496.
- Willems A, Anders M, Garcia A, Vogel A, Yates A, Muszynski J, Alexander P, Steffen K, Emani S, Gehred A, Lyman E, Raman L, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, FCIC F, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. Management of Extracorporeal Membrane Oxygenation Anticoagulation in the Perioperative Period: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e53-e65. PMID: 38959360, PMCID: PMC11216378, DOI: 10.1097/pcc.0000000000003490.
- Muszynski J, Bembea M, Gehred A, Lyman E, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Alexander P, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. Priorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e78-e89. PMID: 38959362, PMCID: PMC11216398, DOI: 10.1097/pcc.0000000000003488.
- Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J, in collaboration with the Pediatric Acute Lung Injury and Sepsis Investigators Network T. Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference*. Pediatric Critical Care Medicine 2024, 25: 643-675. PMID: 38959353, PMCID: PMC11216385, DOI: 10.1097/pcc.0000000000003480.
- Nellis M, Moynihan K, Sloan S, Delaney M, Kneyber M, DiGeronimo R, Alexander P, Muszynski J, Gehred A, Lyman E, Karam O, in collaboration with the Pediatric Critical Care Blood Research Network A. Prophylactic Transfusion Strategies in Children Supported by Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e25-e34. PMID: 38959357, PMCID: PMC11216389, DOI: 10.1097/pcc.0000000000003493.
- Labarinas S, Norbisrath K, Johnson D, Meliones J, Greenleaf C, Salazar J, Karam O. Clinical outcomes in critically ill children on extracorporeal membrane oxygenation with severe thrombocytopenia. Perfusion 2024, 40: 590-598. PMID: 38626382, DOI: 10.1177/02676591241247981.
- Chegondi M, Jawahar A, Hrvojevic L, Badheka A, Karam O. 426: PLATELET MASS INDEX AND RISKS OF BLEEDING AND CLOTTING ON EXTRACORPOREAL MEMBRANE OXYGENATION. Critical Care Medicine 2023, 52: s187-s187. DOI: 10.1097/01.ccm.0000999884.03955.ef.
- Pierce J, Li W, Karam O, Labarinas S. 1578: SCORING SYSTEM FOR EARLY ACTIVATION OF MASSIVE TRANSFUSION PROTOCOLS IN PEDIATRIC TRAUMA PATIENTS. Critical Care Medicine 2023, 52: s760-s760. DOI: 10.1097/01.ccm.0001004468.85444.22.
- Hickey K, Smith M, Karam O, Faraoni D, Demetres M, Duron V, Wu Y, Nellis M. 804: THE EFFICACY OF ANTIFIBRINOLYTICS IN ADOLESCENTS UNDERGOING SCOLIOSIS SURGERY. Critical Care Medicine 2023, 52: s374-s374. DOI: 10.1097/01.ccm.0001001384.14980.68.
- Smith M, Hickey K, Karam O, Faraoni D, Demetres M, Duron V, Wu Y, Nellis M. 793: THE EFFICACY OF ANTIFIBRINOLYTICS IN CHILDREN UNDERGOING CRANIOFACIAL SURGERY. Critical Care Medicine 2023, 52: s369-s369. DOI: 10.1097/01.ccm.0001001340.99864.51.
- Nellis M, Karam O, Aldave G, Rocque B, Bauer D, Network I. Scenario Decision-Making About Plasma and Platelet Transfusion for Intracranial Monitor Placement: Cross-Sectional Survey of Pediatric Intensivists and Neurosurgeons. Pediatric Critical Care Medicine 2023, 25: e205-e213. PMID: 37966339, PMCID: PMC10994730, DOI: 10.1097/pcc.0000000000003414.
- Labarinas S, Singh K, Meliones J, Johnson D, Greenleaf C, Salazar J, Karam O. 105: Clinical Outcomes in Critically Ill Children on Extracorporeal Membrane Oxygenation with Severe Thrombocytopenia. ASAIO Journal 2023, 69: 57-57. DOI: 10.1097/01.mat.0000990932.67126.dc.
- Levasseur J, Fikse L, Mauguen A, Killinger J, Karam O, Nellis M. Bleeding in Critically Ill Children With Malignancy or Hematopoietic Cell Transplant: A Single-Center Prospective Cohort Study. Pediatric Critical Care Medicine 2023, 24: e602-e610. PMID: 37678406, PMCID: PMC10843653, DOI: 10.1097/pcc.0000000000003374.
- Greenfield K, Karam O, O'Meara A. Stuck in the Dark: No Association between Light, Sound, and Delirium in the PICU. Journal Of Pediatric Intensive Care 2023 DOI: 10.1055/s-0043-1770081.
- Aldairi N, Al Ali A, Alabdulqader M, Al Jeraisy M, Cyrus J, Karam O. Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis. Cureus 2023, 15: e39967. PMID: 37416033, PMCID: PMC10320736, DOI: 10.7759/cureus.39967.
- Goel R, Zhu X, Makhani S, Josephson C, White J, Karam O, Nellis M, Gehrie E, Sherpa M, Crowe E, Bloch E, Tobian A. Pediatric firearm injury related emergency department visits and hospitalizations: a population-based study in the United States. The Lancet Regional Health - Americas 2023, 22: 100503. PMID: 37214769, PMCID: PMC10192937, DOI: 10.1016/j.lana.2023.100503.
- Goldstein G, Karam O, Miller Ferguson N. The Effects of Expectation Setting and Bundle Consent on Acute Caregiver Stress in the PICU: A Randomized Controlled Trial. Pediatric Critical Care Medicine 2023, 24: 692-700. PMID: 37125809, DOI: 10.1097/pcc.0000000000003265.
- Carmona C, Nellis M, Karam O. Anticoagulation and hemostasis on extracorporeal membrane oxygenation. Current Opinion In Pediatrics 2023, 35: 297-302. PMID: 36974451, DOI: 10.1097/mop.0000000000001247.
- Cousin V, Rodriguez-Vigouroux R, Karam O, Rimensberger P, Posfay-Barbe K. First nosocomial infections in children supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO). BMC Pediatrics 2023, 23: 89. PMID: 36823601, PMCID: PMC9948414, DOI: 10.1186/s12887-023-03908-3.
- Carmona C, Kuziez M, Freitas C, Cyrus J, Bain J, Karam O. Cardiac manifestations of multisystem inflammatory syndrome of children after SARS-CoV-2 infection: a systematic review and meta-analysis. Cardiology In The Young 2023, 33: 2319-2327. PMID: 36762563, DOI: 10.1017/s104795112300015x.
- Nellis M, An A, Mahmood H, Prishtina F, Hena Z, Karam O. Epidemiology of anticoagulation for children supported by extracorporeal membrane oxygenation in the United States: A Pediatric Hospital Information System database study. Perfusion 2023, 39: 536-542. PMID: 36606508, DOI: 10.1177/02676591221151027.
- Shenker J, Abuelhija H, Karam O, Nellis M. Transfusion Strategies in the 21st Century A Case-Based Narrative Report. Critical Care Clinics 2022, 39: 287-298. PMID: 36898774, DOI: 10.1016/j.ccc.2022.09.005.
- Schertz K, Karam O, Demetres M, Mayadunna S, Faraoni D, Nellis ME. Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis. Pediatric Critical Care Medicine 2022, 23: e517-e529. PMID: 35997516, DOI: 10.1097/pcc.0000000000003049.
- Amigoni A, Simons S, De Hoog M, De Wildt SN, Karam O. Editorial: Sedation and analgesia challenges in critically ill neonates and children. Frontiers In Pediatrics 2022, 10: 1003736. PMID: 36061397, PMCID: PMC9434329, DOI: 10.3389/fped.2022.1003736.
- El-Amin N, Iness A, Cyrus JW, Sisler I, Karam O. Anticoagulation strategies and recurrence of venous thromboembolic events in patients with sickle cell disease: a systematic review and meta-analysis. Annals Of Hematology 2022, 101: 1931-1940. PMID: 35895101, DOI: 10.1007/s00277-022-04901-z.
- Dengler BA, Karam O, Barthol CA, Chance A, Snider LE, Mundy CM, Bounajem MT, Johnson WC, Maita MM, Mendez-Gomez PM, Seifi A, Hafeez S. Ketamine Boluses Are Associated with a Reduction in Intracranial Pressure and an Increase in Cerebral Perfusion Pressure: A Retrospective Observational Study of Patients with Severe Traumatic Brain Injury. Critical Care Research And Practice 2022, 2022: 3834165. PMID: 35637760, PMCID: PMC9148235, DOI: 10.1155/2022/3834165.
- Chegondi M, Vijayakumar N, Badheka A, Karam O. Effect of Platelet Transfusions on Extracorporeal Life Support Oxygenator’s Function. Frontiers In Pediatrics 2022, 10: 826477. PMID: 35321010, PMCID: PMC8936087, DOI: 10.3389/fped.2022.826477.
- Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Network A. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB). Pediatric Critical Care Medicine 2022, 23: 34-51. PMID: 34989711, PMCID: PMC8820267, DOI: 10.1097/pcc.0000000000002851.
- Lieberman L, Karam O, Stanworth SJ, Goobie SM, Crighton G, Goel R, Lacroix J, Nellis ME, Parker RI, Steffen K, Stricker P, Valentine SL, Steiner ME, Network A. Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e37-e49. PMID: 34989704, PMCID: PMC8769367, DOI: 10.1097/pcc.0000000000002857.
- Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Network A. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e1-e13. PMID: 34989701, PMCID: PMC8769352, DOI: 10.1097/pcc.0000000000002854.
- Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yehya N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. 2022, 149: s1-s12. PMID: 34970673, PMCID: PMC9599725, DOI: 10.1542/peds.2021-052888b.
- Faustino EVS, Karam O, Parker RI, Hanson SJ, Brandão LR, Monagle P. Coagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. 2022, 149: s79-s83. PMID: 34970670, DOI: 10.1542/peds.2021-052888l.
- John J, Division of Pediatric Nephrology C, Gipson G, King C, Bunchman T, Karam O, Division of Nephrology V, Division of Pediatric Critical Care Medicine C. Accuracy of Bioimpedance Modalities for Fluid Assessment in Hemodialysis Patients: A Randomized Observational Study. Nephrology - Open Journal 2021, 6: 1-7. DOI: 10.17140/npoj-6-124.
- Tarquinio KM, Karsies T, Shein SL, Beardsley A, Khemani R, Schwarz A, Smith L, Flori H, Karam O, Cao Q, Haider Z, Smirnova E, Serrano MG, Buck GA, Willson DF. Airway microbiome dynamics and relationship to ventilator‐associated infection in intubated pediatric patients. Pediatric Pulmonology 2021, 57: 508-518. PMID: 34811963, PMCID: PMC8809006, DOI: 10.1002/ppul.25769.
- Grunauer M, Mikesell C, Bustamante G, Aronowitz D, Zambrano K, Icaza-Freire A, Gavilanes A, Barrera R, Group T, González J, López-Herce J, Rossetti E, Fabrizio C, Karam O, Saint-Faust M, Biban P, Carlassara S, von Dessauer B, Ordenes N, Urízar F, A A, Canarie M, Miller K, Irazuzta J, Tawfik D, Tucker E, Shilkofski N, Wenchao W, Yuxia Z, See L, Priscilla, Tekin R, Aktar F, Düzkaya D, Dursun O, Ongun E, Yilmaz R, Yildizdas D, Tekgüç H, Sazonov V, Tsoy T, Sazonov V, Saparov A, Sazonov V, Kalmbakh E, Grunauer M, Quiñones E, Eguiguren L, Briones K, Tovilla Y, Gómez S, Torres S, Cobarrubias P, Dmytriiev D, Martínez A, Guzaman G, Sanabria R, Krupanandan R, Ramachandran B, Choraria N, Patel J, Pooni P, Gill K, Appiah J, Heye T, Argaw R, Demtse A, Admasu I. Availability and Quality of Grief and Bereavement Care in Pediatric Intensive Care Units Around the World, Opportunities for Improvement. Frontiers In Pediatrics 2021, 9: 742916. PMID: 34869100, PMCID: PMC8634722, DOI: 10.3389/fped.2021.742916.
- Romano J, Martinez M, Levasseur J, Killinger JS, Karam O, Nellis ME. Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis. Critical Care Explorations 2021, 3: e0572. PMID: 34746797, PMCID: PMC8565795, DOI: 10.1097/cce.0000000000000572.
- Grunauer M, Mikesell C, Bustamante G, Cobo G, Sánchez S, Román A, Icaza-Freire A, Gavilanes A, Wang N, Group T, González J, López-Herce J, Rossetti E, Fabrizio C, Karam O, Saint-Faust M, Biban P, Carlassara S, von Dessauer B, Ordenes N, Urízar F, A A, Canarie M, Miller K, Irazuzta J, Chiriboga N, Tawfik D, Sourkes B, Wang N, Vongsachang H, Tucker E, Shilkofski N, Wang 王, Wenchao R, Yuxia Z, See L, Priscilla, Tekin R, Aktar F, Düzkaya D, Dursun O, Ongun E, Yilmaz R, Yildizdas D, Tekgüç H, Sazonov V, Tsoy T, Sazonov V, Saparov A, Sazonov V, Kalmbakh E, Grunauer M, Eguiguren L, Claudette K, Tovilla Y, Gómez S, Torres S, Cobarrubias P, Dmytriiev D, Martínez A, Guzaman G, Sanabria R, Krupanandan R, Ramachandran B, Choraria N, Patel J, Pooni P, Gill K, Appiah J, Anokye K, Heye T, Argaw R, Demtse A, Admasu I. Pain Assessment and Management in Pediatric Intensive Care Units Around the World, an International, Multicenter Study. Frontiers In Pediatrics 2021, 9: 746489. PMID: 34778135, PMCID: PMC8581242, DOI: 10.3389/fped.2021.746489.
- Goel R, Nellis ME, Karam O, Hanson SJ, Tormey CA, Patel RM, Birch R, Sachais BS, Sola‐Visner M, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Study‐IV‐Pediatric F. Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III). Transfusion 2021, 61: 2589-2600. PMID: 34455598, DOI: 10.1111/trf.16626.
- Sequeira J, Nellis ME, Karam O. Epidemiology of Bleeding in Critically Ill Children. Frontiers In Pediatrics 2021, 9: 699991. PMID: 34422724, PMCID: PMC8371326, DOI: 10.3389/fped.2021.699991.
- Hanson SJ, Karam O, Birch R, Goel R, Patel RM, Sola-Visner M, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Nellis ME, Lung A. Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database. Pediatric Critical Care Medicine 2021, 22: 978-987. PMID: 34261944, PMCID: PMC8570986, DOI: 10.1097/pcc.0000000000002805.
- Crighton GL, Karam O, Nellis ME, Stanworth SJ. Editorial: Hemostatic Challenges in Pediatric Critical Care Medicine. Frontiers In Pediatrics 2021, 9: 697921. PMID: 34322464, PMCID: PMC8311020, DOI: 10.3389/fped.2021.697921.
- Chegondi M, Vijayakumar N, Billa R, Badheka A, Karam O. Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children. Journal Of Pediatric Intensive Care 2021, 12: 228-234. PMID: 37565022, PMCID: PMC10411082, DOI: 10.1055/s-0041-1731434.
- Nguyen DA, De Mul A, Hoskote AU, Cogo P, da Cruz EM, Erickson S, Lasa JJ, Thiagarajan RR, Bembea MM, Karam O, ESPNIC A. Factors Associated With Initiation of Extracorporeal Cardiopulmonary Resuscitation in the Pediatric Population: An International Survey. ASAIO Journal 2021, 68: 413-418. PMID: 34074851, DOI: 10.1097/mat.0000000000001495.
- Nellis ME, Goel R, Hendrickson JE, Birch R, Patel RM, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Sola‐Visner M, Josephson CD, Karam O, Study‐IV‐Pediatric F. Transfusion practices in a large cohort of hospitalized children. Transfusion 2021, 61: 2042-2053. PMID: 33973660, DOI: 10.1111/trf.16443.
- Nellis ME, Vasovic LV, Goel R, Karam O. Epidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study. Frontiers In Pediatrics 2021, 9: 673613. PMID: 34041211, PMCID: PMC8141845, DOI: 10.3389/fped.2021.673613.
- Karsies T, Tarquinio K, Shein SL, Beardsley AL, Prentice E, Karam O, Fontela P, Moore-Clingenpeel M, Willson DF. Compliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated INfection (VAIN2) Study*. Pediatric Critical Care Medicine 2021, 22: 859-869. PMID: 33965989, DOI: 10.1097/pcc.0000000000002761.
- Patel RM, Hendrickson JE, Nellis ME, Birch R, Goel R, Karam O, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Sola-Visner M, National Heart L, Mast A, Hod E, Custer B, Vichinsky E, Spencer B, Mathew S, Harris D, Busch M, Norris P, Ness P, Kleinman S, Tamburro R, Glynn S, Malkin K. Variation in Neonatal Transfusion Practice. The Journal Of Pediatrics 2021, 235: 92-99.e4. PMID: 33836184, PMCID: PMC8316298, DOI: 10.1016/j.jpeds.2021.04.002.
- Schapka E, Gee J, Cyrus JW, Goldstein G, Greenfield K, Marinello M, Karam O. Lung Ultrasound versus Chest X-Ray for the Detection of Fluid Overload in Critically Ill Children: A Systematic Review. Journal Of Pediatric Intensive Care 2021, 11: 177-182. PMID: 35928036, PMCID: PMC9345674, DOI: 10.1055/s-0041-1725123.
- Barbateskovic M, Koster TM, Eck RJ, Maagaard M, Afshari A, Blokzijl F, Cronhjort M, Dieperink W, Fabritius ML, Feinberg J, French C, Gareb B, Geisler A, Granholm A, Hiemstra B, Hu R, Imberger G, Jensen BT, Jonsson AB, Karam O, Kong Z, Korang SK, Koster G, Lai B, Liang N, Lundstrøm LH, Marker S, Meyhoff TS, Nielsen EE, Nørskov AK, Munch MW, Risom EC, Rygård SL, Safi S, Sethi N, Sjövall F, Lauridsen SV, van Bakelen N, Volbeda M, van der Horst ICC, Gluud C, Perner A, Møller MH, Keus E, Wetterslev J. A new tool to assess Clinical Diversity In Meta‐analyses (CDIM) of interventions. Journal Of Clinical Epidemiology 2021, 135: 29-41. PMID: 33561529, DOI: 10.1016/j.jclinepi.2021.01.023.
- Aran AA, Karam O, Nellis ME. Bleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation. Frontiers In Pediatrics 2021, 9: 611680. PMID: 33585373, PMCID: PMC7873638, DOI: 10.3389/fped.2021.611680.
- Karam O, Nellis ME. Transfusion management for children supported by extracorporeal membrane oxygenation. Transfusion 2021, 61: 660-664. PMID: 33491189, DOI: 10.1111/trf.16272.
- Dengler B, Karam O, Barthol C, Hafeez S. Ketamine Boluses Decrease Intracranial Pressure and Improve Cerebral Perfusion Pressure in Patients with Severe Traumatic Brain Injury. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_450.
- Kahn S, Chegondi M, Nellis ME, Karam O. Overview of Plasma and Platelet Transfusions in Critically Ill Children. Frontiers In Pediatrics 2020, 8: 601659. PMID: 33282804, PMCID: PMC7691248, DOI: 10.3389/fped.2020.601659.
- Greenfield KD, Karam O, O'Meara A. Brighter Days May Be Ahead: Continuous Measurement of Pediatric Intensive Care Unit Light and Sound. Frontiers In Pediatrics 2020, 8: 590715. PMID: 33194924, PMCID: PMC7649178, DOI: 10.3389/fped.2020.590715.
- Nellis ME, Spinella PC, Tucci M, Stanworth SJ, Steiner ME, Cushing MM, Davis PJ, Karam O, The Pediatric Acute Lung Injury and Sepsis Investigators network P. Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children. Transfusion 2020, 60: 2849-2858. PMID: 32959409, PMCID: PMC8396066, DOI: 10.1111/trf.16094.
- Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion 2020, 36: 501-512. PMID: 32862767, PMCID: PMC8216320, DOI: 10.1177/0267659120952982.
- Demaret P, Karam O. Designing Appropriate and Individualized Transfusion Strategies: Finding the Sweet Spot. Pediatric Critical Care Medicine 2020, 21: 770-772. PMID: 32769943, DOI: 10.1097/pcc.0000000000002369.
- Biboulet P, Motais C, Pencole M, Karam O, Dangelser G, Smilevitch P, Maissiat G, Capdevila X, Bringuier S. Preoperative erythropoietin within a patient blood management program decreases both blood transfusion and postoperative anemia: a prospective observational study. Transfusion 2020, 60: 1732-1740. PMID: 32681743, DOI: 10.1111/trf.15900.
- Greenfield K, Karam O, O'Meara A. Are Brighter Days Ahead? Light and Sound in the Pediatric Intensive Care Unit. 2020, 146: 161-162. DOI: 10.1542/peds.146.1ma2.161.
- Goel R, Josephson CD, Patel EU, Petersen MR, Packman Z, Gehrie E, Bloch EM, Lokhandwala P, Ness PM, Katz L, Nellis M, Karam O, Tobian AAR. Individual‐ and hospital‐level correlates of red blood cell, platelet, and plasma transfusions among hospitalized children and neonates: a nationally representative study in the United States. Transfusion 2020, 60: 1700-1712. PMID: 32589286, PMCID: PMC7951993, DOI: 10.1111/trf.15855.
- Klee P, Rimensberger PC, Karam O. Association Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass. Frontiers In Pediatrics 2020, 8: 332. PMID: 32656170, PMCID: PMC7325592, DOI: 10.3389/fped.2020.00332.
- Karam O, Goel R, Dalton H, Nellis ME. Epidemiology of Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation. Critical Care Medicine 2020, 48: e698-e705. PMID: 32697511, DOI: 10.1097/ccm.0000000000004417.
- Hughes A, Carter K, Cyrus J, Karam O. Pleural Effusions After Congenital Cardiac Surgery Requiring Readmission: A Systematic Review and Meta-analysis. Pediatric Cardiology 2020, 41: 1145-1152. PMID: 32424719, DOI: 10.1007/s00246-020-02365-4.
- Karam O, Goel R, Dalton H, Nellis M. Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation. 2020, a1742-a1742. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1742.
- Karam O, Klee P, Rimensberger P. Association Between Lactates, Blood Glucose, and Oxygen Extraction in Critically Ill Children After Cardiopulmonary Bypass. 2020, a6311-a6311. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6311.
- Iqbal O'Meara AM, Miller Ferguson N, Zven SE, Karam OL, Meyer LC, Bigbee JW, Sato-Bigbee C. Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats. Critical Care Explorations 2020, 2: e0105. PMID: 32426747, PMCID: PMC7188419, DOI: 10.1097/cce.0000000000000105.
- Goel R, Josephson CD, Patel EU, Petersen MR, Makhani S, Frank SM, Ness PM, Bloch EM, Gehrie EA, Lokhandwala PM, Nellis MM, Karam O, Shaz BH, Patel RM, Tobian AAR. Perioperative Transfusions and Venous Thromboembolism. 2020, 145: e20192351. PMID: 32198293, PMCID: PMC7111487, DOI: 10.1542/peds.2019-2351.
- Demaret P, Karam O, Labreuche Bst J, Chiusolo F, Mayordomo Colunga J, Erickson S, Nellis ME, Perez MH, Ray S, Tucci M, Willems A, Duhamel A, Lebrun F, Loeckx I, Mulder A, Leteurtre S. How 217 Pediatric Intensivists Manage Anemia at PICU Discharge: Online Responses to an International Survey. Pediatric Critical Care Medicine 2020, 21: e342-e353. PMID: 32217901, DOI: 10.1097/pcc.0000000000002307.
- Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatric Critical Care Medicine 2020, 21: 267-275. PMID: 31644453, PMCID: PMC7060816, DOI: 10.1097/pcc.0000000000002160.
- Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine 2020, 46: 10-67. PMID: 32030529, PMCID: PMC7095013, DOI: 10.1007/s00134-019-05878-6.
- Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine 2020, 46: 1-9. PMID: 32030528, DOI: 10.1007/s00134-019-05877-7.
- Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine 2020, 21: 186-195. PMID: 32032264, DOI: 10.1097/pcc.0000000000002197.
- Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine 2020, 21: e52-e106. PMID: 32032273, DOI: 10.1097/pcc.0000000000002198.
- Nellis ME, Tucci M, Lacroix J, Spinella PC, Haque KD, Stock A, Steiner ME, Faustino EVS, Zantek ND, Davis PJ, Stanworth SJ, Cholette JM, Parker RI, Demaret P, Kneyber MCJ, Russell RT, Stricker PA, Vogel AM, Willems A, Josephson CD, Luban NLC, Loftis LL, Leteurtre S, Stocker CF, Goobie SM, Karam O. Bleeding Assessment Scale in Critically Ill Children (BASIC): Physician-Driven Diagnostic Criteria for Bleeding Severity. Critical Care Medicine 2019, 47: 1766-1772. PMID: 31567407, PMCID: PMC6861687, DOI: 10.1097/ccm.0000000000004025.
- Nellis ME, Dalton H, Karam O. Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome. Critical Care Medicine 2019, 47: e886-e892. PMID: 31449061, PMCID: PMC8608374, DOI: 10.1097/ccm.0000000000003968.
- François T, Emeriaud G, Karam O, Tucci M. Transfusion in children with acute respiratory distress syndrome. Annals Of Translational Medicine 2019, 7: 511. PMID: 31728364, PMCID: PMC6828792, DOI: 10.21037/atm.2019.08.28.
- Demaret P, Valla FV, Behal H, Mimouni Y, Baudelet JB, Karam O, Recher M, Duhamel A, Tucci M, Javouhey E, Leteurtre S. Anemia at Discharge From the PICU: A Bicenter Descriptive Study. Pediatric Critical Care Medicine 2019, 20: e400-e409. PMID: 31246740, DOI: 10.1097/pcc.0000000000002015.
- Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections.Shein SL, Karam O, Beardsley A, Karsies T, Prentice E, Tarquinio KM, Willson DF. Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections. Pediatric Critical Care Medicine 2019, 20: 697-706. PMID: 30985606, DOI: 10.1097/pcc.0000000000001942.
- Doell C, De Mul A, Nguyen DA, Perez MH, Karam O, Cannizzaro V. Reply to: Prognostic Evaluation of Mortality after Pediatric Resuscitation Assisted by Extracorporeal Life Support. Journal Of Pediatric Intensive Care 2019, 08: 193-194. PMID: 31404921, PMCID: PMC6687445, DOI: 10.1055/s-0039-1692969.
- Nellis ME, Goel R, Karam O. Transfusion Management in Pediatric Oncology Patients. Hematology/Oncology Clinics Of North America 2019, 33: 903-913. PMID: 31466612, DOI: 10.1016/j.hoc.2019.05.011.
- Nellis ME, Levasseur J, Stribling J, Faustino EVS, Zantek ND, Sheth S, Karam O. Bleeding Scales Applicable to Critically Ill Children: A Systematic Review. Pediatric Critical Care Medicine 2019, 20: 603-607. PMID: 30925573, DOI: 10.1097/pcc.0000000000001943.
- Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis. Pediatric Critical Care Medicine 2019, 20: e342-e351. PMID: 31107379, DOI: 10.1097/pcc.0000000000001987.
- Karam O, Nellis ME, Zantek ND, Lacroix J, Faustino EVS. Criteria for Clinically Relevant Bleeding in Critically Ill Children. Pediatric Critical Care Medicine 2019, Publish Ahead of Print: &na;. PMID: 30575698, DOI: 10.1097/pcc.0000000000001828.
- Buyck M, Manzano S, Haddad K, Moncousin AC, Galetto-Lacour A, Blondon K, Karam O. Effects of Blindfold on Leadership in Pediatric Resuscitation Simulation: A Randomized Trial. Frontiers In Pediatrics 2019, 7: 10. PMID: 30838188, PMCID: PMC6383074, DOI: 10.3389/fped.2019.00010.
- Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Effects of ABO Matching of Platelet Transfusions in Critically Ill Children*. Pediatric Critical Care Medicine 2019, 20: e61-e69. PMID: 30422914, PMCID: PMC6709973, DOI: 10.1097/pcc.0000000000001779.
- Calinescu AM, Karam O, Wilde JCH, Ansari M, McLin VA, Wildhaber BE. International survey on anticoagulation and antiplatelet strategies after pediatric liver transplantation. Pediatric Transplantation 2018, 23: e13317. PMID: 30393923, DOI: 10.1111/petr.13317.
- Keir AK, Karam O, Hodyl N, Stark MJ, Liley HG, Shah PS, Stanworth SJ, Group O. International, multicentre, observational study of fluid bolus therapy in neonates. Journal Of Paediatrics And Child Health 2018, 55: 632-639. PMID: 30328174, DOI: 10.1111/jpc.14260.
- Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatric Critical Care Medicine 2018, 19: 884-898. PMID: 30180125, PMCID: PMC6126913, DOI: 10.1097/pcc.0000000000001613.
- Karam O, Russell RT, Stricker P, Vogel AM, Bateman ST, Valentine SL, Spinella PC. Recommendations on RBC Transfusion in Critically Ill Children With Nonlife-Threatening Bleeding or Hemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatric Critical Care Medicine 2018, 19: s127-s132. PMID: 30161067, PMCID: PMC6121734, DOI: 10.1097/pcc.0000000000001605.
- Nellis ME, Karam O, Mauer E, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Platelet Transfusion Practices in Critically Ill Children. Critical Care Medicine 2018, 46: 1309-1317. PMID: 29727368, PMCID: PMC6476545, DOI: 10.1097/ccm.0000000000003192.
- De Mul A, Nguyen DA, Doell C, Perez MH, Cannizzaro V, Karam O. Prognostic Evaluation of Mortality after Pediatric Resuscitation Assisted by Extracorporeal Life Support. Journal Of Pediatric Intensive Care 2018, 08: 057-063. PMID: 31093456, PMCID: PMC6517051, DOI: 10.1055/s-0038-1667012.
- Arni D, Wildhaber BE, McLin V, Rimensberger PC, Ansari M, Fontana P, Karam O. Effects of plasma transfusions on antithrombin levels after paediatric liver transplantation. Vox Sanguinis 2018, 113: 569-576. PMID: 29761839, DOI: 10.1111/vox.12664.
- Nellis ME, Karam O. Assessing our current practice: point prevalence studies in transfusion medicine. Transfusion 2018, 58: 843-845. PMID: 29380394, DOI: 10.1111/trf.14492.
- Janaillac M, Beausoleil TP, Barrington KJ, Raboisson MJ, Karam O, Dehaes M, Lapointe A. Correlations between near-infrared spectroscopy, perfusion index, and cardiac outputs in extremely preterm infants in the first 72 h of life. European Journal Of Pediatrics 2018, 177: 541-550. PMID: 29374830, DOI: 10.1007/s00431-018-3096-z.
- Broccolo M, Favez N, Karam O. Perceived changes in behavior and values after a red blood cell transfusion. International Journal Of Clinical Transfusion Medicine 2017, 6: 1-5. DOI: 10.2147/ijctm.s155338.
- Valpacos M, Arni D, Keir A, Aspirot A, Wilde JCH, Beasley S, De Luca D, Pfister RE, Karam O. Diagnosis and Management of Necrotizing Enterocolitis: An International Survey of Neonatologists and Pediatric Surgeons. Neonatology 2017, 113: 170-176. PMID: 29241163, DOI: 10.1159/000484197.
- Demaret P, Karam O, Tucci M, Lacroix J, Behal H, Duhamel A, Lebrun F, Mulder A, Leteurtre S. Anemia at pediatric intensive care unit discharge: prevalence and risk markers. Annals Of Intensive Care 2017, 7: 107. PMID: 29067568, PMCID: PMC5655401, DOI: 10.1186/s13613-017-0328-8.
- Zellweger A, Eckert P, Karam O, Cedraschi C, Moretti D, Majmou H, Carre D, Ludwig V, Gasche Y. A Quantitative Pilot Study on Donation after Cardiac Death (DCD). Transplantation 2017, 101: s21. DOI: 10.1097/01.tp.0000525002.75001.e9.
- Camazine MN, Karam O, Colvin R, Leteurtre S, Demaret P, Tucci M, Muszynski JA, Stanworth S, Spinella PC. Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*. Pediatric Critical Care Medicine 2017, 18: e215-e223. PMID: 28350560, DOI: 10.1097/pcc.0000000000001149.
- Delcò C, Karam O, Pfister R, Gervaix A, Renzi G, Emonet S, Schrenzel J, Posfay-Barbe KM. Rapid detection and ruling out of neonatal sepsis by PCR coupled with Electrospray Ionization Mass Spectrometry (PCR/ESI-MS). Early Human Development 2017, 108: 17-22. PMID: 28343091, DOI: 10.1016/j.earlhumdev.2017.03.004.
- Factors influencing plasma transfusion practices in paediatric intensive care units around the worldKaram O, Demaret P, Duhamel A, Shefler A, Spinella PC, Tucci M, Leteurtre S, Stanworth SJ, investigators T. Factors influencing plasma transfusion practices in paediatric intensive care units around the world. Vox Sanguinis 2017, 112: 140-149. PMID: 28176380, DOI: 10.1111/vox.12490.
- Sternberg J, Pfister R, Karam O. Hypoglycemic relapse in term infants treated with glucose infusion. Journal Of Clinical Neonatology 2017, 6: 163-167. DOI: 10.4103/jcn.jcn_10_17.
- Karam O, Gebistorf F, Wetterslev J, Afshari A. The effect of inhaled nitric oxide in acute respiratory distress syndrome in children and adults: a Cochrane Systematic Review with trial sequential analysis. Anaesthesia 2016, 72: 106-117. PMID: 27762438, DOI: 10.1111/anae.13628.
- Bragard I, Farhat N, Seghaye MC, Karam O, Neuschwander A, Shayan Y, Schumacher K. Effectiveness of a High-Fidelity Simulation-Based Training Program in Managing Cardiac Arrhythmias in Children: A Randomized Pilot Study. Pediatric Emergency Care 2016, 35: 412-418. PMID: 27763955, DOI: 10.1097/pec.0000000000000931.
- Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Stanworth SJ, Tucci M, Leteurtre S, for the PlasmaTV investigators. Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions. Annals Of Intensive Care 2016, 6: 98. PMID: 27714707, PMCID: PMC5053948, DOI: 10.1186/s13613-016-0197-6.
- Arni D, Karam O, Vidal I, Rimensberger PC, Hanquinet S, Wildhaber BE. Are Scores Reliable in Predicting the Need for Surgery and Mortality in Necrotizing Enterocolitis? European Journal Of Pediatric Surgery 2016, 27: 330-335. PMID: 27706524, DOI: 10.1055/s-0036-1593382.
- Pregernig A, Karam O. Potential Pediatric Organ Donors After Cardiac Death. Transplantation Proceedings 2016, 48: 2588-2591. PMID: 27788786, DOI: 10.1016/j.transproceed.2016.06.049.
- Klee P, Arni D, Saudan S, Schwitzgebel VM, Sharma R, Karam O, Rimensberger PC. Ketosis After Cardiopulmonary Bypass in Children Is Associated With an Inadequate Balance Between Oxygen Transport and Consumption*. Pediatric Critical Care Medicine 2016, 17: 852-859. PMID: 27472253, DOI: 10.1097/pcc.0000000000000880.
- Gebistorf F, Karam O, Wetterslev J, Afshari A. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults. Cochrane Database Of Systematic Reviews 2016, 2018: cd002787. PMID: 27347773, PMCID: PMC6464789, DOI: 10.1002/14651858.cd002787.pub3.
- Janaillac M, Labarinas S, Pfister RE, Karam O. Accuracy of Transcutaneous Carbon Dioxide Measurement in Premature Infants. Critical Care Research And Practice 2016, 2016: 8041967. PMID: 27375901, PMCID: PMC4916268, DOI: 10.1155/2016/8041967.
- Karam O, Tucci M. Massive Transfusion in Children. Transfusion Medicine Reviews 2016, 30: 213-216. PMID: 27287298, DOI: 10.1016/j.tmrv.2016.05.010.
- Brunner A, Dubois N, Rimensberger PC, Karam O. Identifying Prognostic Criteria for Survival after Resuscitation Assisted by Extracorporeal Membrane Oxygenation. Critical Care Research And Practice 2016, 2016: 9521091. PMID: 27006826, PMCID: PMC4781941, DOI: 10.1155/2016/9521091.
- Hagerman A, Karam O. Molecular Adsorbent Recirculating System (MARS™ en réanimation pédiatrique. Médecine Intensive Réanimation 2016, 25: 239-245. DOI: 10.1007/s13546-015-1162-3.
- Karam O, Pregernig A. Donneurs d’organes potentiels aux soins intensifs pédiatriques. 2016, 9 DOI: 10.24894/bf.2016.09005.
- Delco-Volonte C, Posfay-Barbe K, Karam O. Rapid diagnosis to rule out bacterial bloodstream infection in neonates. Intensive Care Medicine Experimental 2015, 3: a298. PMCID: PMC4798179, DOI: 10.1186/2197-425x-3-s1-a298.
- Demaret P, Tucci M, Karam O, Trottier H, Ducruet T, Lacroix J. Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 505-514. PMID: 25905491, DOI: 10.1097/pcc.0000000000000423.
- Karam O, Demaret P, Shefler A, Leteurtre S, Spinella PC, Stanworth SJ, Tucci M. Indications and Effects of Plasma Transfusions in Critically Ill Children. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 1395-1402. PMID: 25859890, DOI: 10.1164/rccm.201503-0450oc.
- Try A, Karam O, Delcò C, Kraemer K, Boulvain M, Pfister RE. Moderate and extended neonatal resuscitations occur in one in 10 births and require specialist cover 24 hours a day. Acta Paediatrica 2015, 104: 589-595. PMID: 25619977, DOI: 10.1111/apa.12909.
- Karam O, Tucci M. Primum Non Nocere*. Pediatric Critical Care Medicine 2015, 16: 189-190. PMID: 25647127, DOI: 10.1097/pcc.0000000000000326.
- Grazioli S, Karam O, Rimensberger PC. New Generation Neonatal High Frequency Ventilators: Effect of Oscillatory Frequency and Working Principles on Performance. Respiratory Care 2014, 60: 363-370. PMID: 25406342, DOI: 10.4187/respcare.03048.
- Labarinas S, Arni D, Karam O. Transfusions de plasma en réanimation pédiatrique. Médecine Intensive Réanimation 2014, 23: 455-462. DOI: 10.1007/s13546-014-0900-2.
- Karam O, Tucci M, Combescure C, Lacroix J, Rimensberger PC. Plasma transfusion strategies for critically ill patients. Cochrane Database Of Systematic Reviews 2013, 2013: cd010654. PMID: 24374651, PMCID: PMC12001317, DOI: 10.1002/14651858.cd010654.pub2.
- Shayan Y, Gravel J, Bhanji F, Weiss M, Karam O, Manzano S, Bank I, Choker G, Levy A. Board 424 - Research Abstract Validation of a Tool for the Assessment of Trainees During Simulated Pediatric Resuscitation (Submission #967). Simulation In Healthcare The Journal Of The Society For Simulation In Healthcare 2013, 8: 593. DOI: 10.1097/01.sih.0000441676.11945.49.
- Vignaux L, Grazioli S, Piquilloud L, Bochaton N, Karam O, Levy-Jamet Y, Jaecklin T, Tourneux P, Jolliet P, Rimensberger PC. Patient–Ventilator Asynchrony During Noninvasive Pressure Support Ventilation and Neurally Adjusted Ventilatory Assist in Infants and Children. Pediatric Critical Care Medicine 2013, 14: e357-e364. PMID: 23863816, DOI: 10.1097/pcc.0b013e3182917922.
- Vignaux L, Grazioli S, Piquilloud L, Bochaton N, Karam O, Jaecklin T, Levy-Jamet Y, Tourneux P, Jolliet P, Rimensberger PC. Optimizing Patient-Ventilator Synchrony During Invasive Ventilator Assist in Children and Infants Remains a Difficult Task*. Pediatric Critical Care Medicine 2013, 14: e316-e325. PMID: 23842584, DOI: 10.1097/pcc.0b013e31828a8606.
- Karam O, Tucci M, Lacroix J, Rimensberger PC, Network C. International survey on plasma transfusion practices in critically ill children. Transfusion 2013, 54: 1125-1132. PMID: 24032693, DOI: 10.1111/trf.12393.
- Karam O, Tucci M, Combescure C, Lacroix J, Rimensberger P. Plasma transfusion strategies for critically ill patients. 2013 DOI: 10.1002/14651858.cd010654.
- Labarinas S, Arni D, Karam O. Plasma in the PICU: why and when should we transfuse? Annals Of Intensive Care 2013, 3: 16. PMID: 23725411, PMCID: PMC3698065, DOI: 10.1186/2110-5820-3-16.
- Karam O, Lacroix J, Robitaille N, Rimensberger PC, Tucci M. Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study. Vox Sanguinis 2013, 104: 342-349. PMID: 23294337, DOI: 10.1111/vox.12009.
- Karam O, Tucci M, Ducruet T, Hume H, Lacroix J, Gauvin F. Mortality associated with restrictive threshold for red blood cell transfusion in pediatric patients with sepsis. Pediatric Critical Care Medicine 2012, 13: 495. DOI: 10.1097/pcc.0b013e31824fbefe.
- Karam O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F. Red blood cell transfusion thresholds in pediatric patients with sepsis*. Pediatric Critical Care Medicine 2011, 12: 512-518. PMID: 21057356, DOI: 10.1097/pcc.0b013e3181fe344b.
- Karam O, Tucci M, Ducruet T, Hume H, Lacroix J, Gauvin F. Red blood cell transfusion thresholds in pediatric septic patients. Critical Care 2011, 15: p428. PMCID: PMC3068357, DOI: 10.1186/cc9848.
- Karam O, Roy M, Barrington K, Janvier A. Long-distance air transport of an infant weighing less than 500 g: Is it in the patient’s best interest? Paediatrics & Child Health 2011, 16: 79-81. PMID: 22294866, PMCID: PMC3043038, DOI: 10.1093/pch/16.2.79.
- Lacroix J, Tucci M, Tinmouth A, Gauvin F, Karam O. Chapter 82 Transfusion Medicine. 2011, 1162-1176. DOI: 10.1016/b978-0-323-07307-3.10082-5.
- Karam O, Sanchez O, Wildhaber B, La Scala G. National Survey on Abdominal Trauma Practices of Pediatric Surgeons. European Journal Of Pediatric Surgery 2010, 20: 334-338. PMID: 20976655, DOI: 10.1055/s-0030-1261885.
- Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, Hébert PC, Hutchison JS, Hume HA, Tucci M, Network O. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion 2010, 50: 1902-1913. PMID: 20456697, DOI: 10.1111/j.1537-2995.2010.02661.x.
- Karam O, Tucci M, Bateman ST, Ducruet T, Spinella PC, Randolph AG, Lacroix J. Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study. Critical Care 2010, 14: r57. PMID: 20377853, PMCID: PMC2887178, DOI: 10.1186/cc8953.
- Karam O, Tucci M, Toledano BJ, Robitaille N, Cousineau J, Thibault L, Lacroix J, Le Deist F. Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion 2009, 49: 2326-2334. PMID: 19624600, DOI: 10.1111/j.1537-2995.2009.02319.x.
- Karam O, Sanchez O, Wildhaber B, Chardot C, La Scala G. Blunt abdominal trauma in children: a score to predict the absence of organ injury. Critical Care 2009, 13: p421. PMCID: PMC4084307, DOI: 10.1186/cc7585.
- Karam O, Tucci M, Bateman S, Ducruet T, Spinella P, Randolph A, Lacroix J. Effect of length of storage of red blood cell units on outcome in critically ill children. Critical Care 2009, 13: p417. PMCID: PMC4084303, DOI: 10.1186/cc7581.
- Karam O, Sanchez O, Chardot C, La Scala G. Blunt Abdominal Trauma in Children: A Score to Predict the Absence of Organ Injury. The Journal Of Pediatrics 2009, 154: 912-917. PMID: 19230903, DOI: 10.1016/j.jpeds.2009.01.001.
- Karam O, Donatiello C, Van Lancker E, Chritin V, Pfister RE, Rimensberger PC. Noise levels during nCPAP are flow-dependent but not device-dependent. Archives Of Disease In Childhood Fetal & Neonatal 2007, 93: f132-f134. PMID: 18089628, DOI: 10.1136/adc.2007.129098.
- Karam O, da Cruz E, Rimensberger PC. VGAM induced high-flow congestive heart failure responsive to PGE1 infusion. International Journal Of Cardiology 2007, 132: e60-e62. PMID: 18022260, DOI: 10.1016/j.ijcard.2007.08.020.
- Bottani A, Orrico A, Galli L, Karam O, Haenggeli CA, Ferey S, Conrad B. Unilateral focal polymicrogyria in a patient with classical Aarskog-Scott syndrome due to a novel missense mutation in an evolutionary conserved RhoGEF domain of the faciogenital dysplasia gene FGD1. American Journal Of Medical Genetics. Part A 2007, 143A: 2334-8. PMID: 17847065, DOI: 10.1002/ajmg.a.31733.
- * O, La Scala * G, Le Coultre C, Chardot C. Liver Function Tests in Children with Blunt Abdominal Traumas. European Journal Of Pediatric Surgery 2007, 17: 313-316. PMID: 17968786, DOI: 10.1055/s-2007-965533.
- Karam O, Pfister RE, Extermann P, La Scala GC. Congenital lingual cysts. Journal Of Pediatric Surgery 2007, 42: e25-e27. PMID: 17448749, DOI: 10.1016/j.jpedsurg.2007.01.060.
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