Madhav Menon, MBBS, MD
Nephrology
Telehealth is available
Patient type treated
Adult
Accepting new patients
Yes
Referral required
From patients or physicians
Biography
Madhav Menon, MD, is a nephrologist who specializes in kidney-related conditions, including chronic kidney disease and caring for patients in need of kidney transplant. He also treats kidney fibrosis (internal scar tissue) and nephrotic syndrome (excessive protein loss in urine).
As an associate professor at Yale School of Medicine, Dr. Menon researches the effects of certain genetic variants on kidney function and potential therapeutic strategies to improve patient outcomes, including with transplant.
Dr. Menon received his medical training from Calicut University and completed his residency in internal medicine at the State University of New York, Upstate Medical University. He further pursued fellowships in nephrology and kidney pancreas transplantation at the Icahn School of Medicine at Mount Sinai.
Titles
- Associate Professor
- Director of Research in Kidney Transplantation, Nephrology
- Steering committee member, Human and Translational Immunology Program
Education & Training
- FellowshipRecanati-Miller Transplant institute at Mount Sinai (2014)
- Post doctoral FellowshipIcahn School of Medicine at Mount Sinai (2013)
- FellowshipIcahn School of Medicine at Mount Sinai (2012)
- ResidencyState University of New York, Upstate Medical University (2010)
- Chief ResidencyPGIMER (2006)
- MDPGIMER, Internal Medicine (2006)
- MBBSCalicut University (2002)
Additional Information
Honors & Recognitions
- Blavatnik accelarator award: Yale ventures (2024)
- Elected to the American Society of Clinical Investigation: American Society of Clinical Investigation (2024)
- International Society of Nephrology- Kidney International Early career researcher Award: International Society of Nephrology (2021)
- AST Award for Achievement in Basic Science, Early Career: American Society of Transplantation (2020)
- Harold and Lamport Golden Clinical Research Award: Icahn School of Medicine at Mount Sinai (2019)
- New Investigator Award: American Heart Association, Council on Kidney and Cardiovascular disease (2017)
- Young Investigator Award: American Heart Association, Council on Kidney and Cardiovascular disease (2016)
- Young Investigator Award: American Society of Transplantation, and The Transplantation Society (2014)
- Ben J Lipps Fellowship Award: American Society of Nephrology (2012)
- Williams J Williams Award: Medicine, State University of New York, Syracuse for "Clinical acumen, Professionalism and teaching ability." (2010)
Professional Service
- NIH NIAID Study section (2024 - 2027): Immunobiology of Transplantation and Alloimmunity
- American society of Nephrology (2024 - 2027): Editorial board for all ASN journals JASN, CJASN, Kidney-360
- American Society of Transplantation (2021 - 2023): Scientific Review Committee
- Dutch Kidney Foundation (2021 - Present): Grant Reviewer
- Medical research Council, UK (2019): Grant Reviewer
- Hongkong-China Medical Research Foundation (2019): Grant Reviewer
- Agence nationale de la recherche, France (2019 - Present): Grant Reviewer
- Clinical Transplantation, Wiley Publishers (2019 - Present): Associate Editor
- Journal of the American Society of Nephrology (2018 - 2021): Editorial Fellow, Transplantation
Publications
- Chutani A, Guevara-Pineda D, Lerner G, Menon M. Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies. Transplant International 2024, 37: 13365. PMID: 39640250, PMCID: PMC11617188, DOI: 10.3389/ti.2024.13365.
- Reghuvaran A, Kumar A, Barsotti G, Pell J, Tanvir E, He J, Menon M. Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024qmq3drgr. DOI: 10.1681/asn.2024qmq3drgr.
- Zhang Z, Sun Z, Heeger P, Menon M. Genetic ancestry, proportion of African ancestry, and apolipoprotein L1 risk variants in kidney recipients. American Journal Of Transplantation 2024, 24: 1710-1712. PMID: 38734416, DOI: 10.1016/j.ajt.2024.05.004.
- Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.
- Cravedi P, Riella L, Ford M, Valujskikh A, Menon M, Kirk A, Alegre M, Alessandrini A, Feng S, Kehn P, Najafian N, Hancock W, Heeger P, Maltzman J, Mannon R, Nadig S, Odim J, Turnquist H, Shaw J, West L, Luo X, Chong A, Bromberg J, group A. Advancing mouse models for transplantation research. American Journal Of Transplantation 2024, 24: 1362-1368. PMID: 38219866, DOI: 10.1016/j.ajt.2024.01.006.
- Yi Z, Xi C, Menon M, Cravedi P, Tedla F, Soto A, Sun Z, Liu K, Zhang J, Wei C, Chen M, Wang W, Veremis B, Garcia-Barros M, Kumar A, Haakinson D, Brody R, Azeloglu E, Gallon L, O'Connell P, Naesens M, Shapiro R, Colvin R, Ward S, Salem F, Zhang W. A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization. Kidney International 2023, 105: 281-292. PMID: 37923131, PMCID: PMC10892475, DOI: 10.1016/j.kint.2023.09.031.
- Sun Z, Zhang Z, Banu K, Gibson I, Colvin R, Yi Z, Zhang W, De Kumar B, Reghuvaran A, Pell J, Manes T, Djamali A, Gallon L, O'Connell P, He J, Pober J, Heeger P, Menon M. Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival. Journal Of Clinical Investigation 2023, 133: e170420. PMID: 37676733, PMCID: PMC10617779, DOI: 10.1172/jci170420.
- Pell J, Nagata S, Menon M. Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm. Kidney360 2023, 4: e1325-e1331. PMID: 37461136, PMCID: PMC10550003, DOI: 10.34067/kid.0000000000000216.
- Chen M, Menon M, Wang W, Fu J, Yi Z, Sun Z, Liu J, Li Z, Mou L, Banu K, Lee S, Dai Y, Anandakrishnan N, Azeloglu E, Lee K, Zhang W, Das B, He J, Wei C. HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy. Nature Communications 2023, 14: 4297. PMID: 37463911, PMCID: PMC10354075, DOI: 10.1038/s41467-023-40086-3.
- Reghuvaran A, Lin Q, Basgen J, Banu K, Shi H, Vashist A, Pell J, Perinchery S, He J, Moledina D, Wilson F, Menon M. Comparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruli. Physiological Reports 2023, 11: e15688. PMID: 37423891, PMCID: PMC10329935, DOI: 10.14814/phy2.15688.
- Bane O, Feng L, Xia D, Al-Mubarak H, Cuevas J, Muthukumar T, Dyke J, Menon M, Farouk S, Taouli B, Lewis S. Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) MRI for Rapid Free-Breathing 3D T1 Mapping of Renal Allografts. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/1286.
- Pell J, Reghuvaran A, Nagata S, Banu K, He J, Craft J, Shi H, Chernova I, Ishibe S, Menon M. WCN23-0470 BAC-transgenic mice show a novel T-cell intrinsic role for FSGS-associated APOL1 risk-variants in T-cell activation. Kidney International Reports 2023, 8: s392-s393. DOI: 10.1016/j.ekir.2023.02.882.
- Virmani S, Rao A, Menon M. Allograft tissue under the microscope: only the beginning. Current Opinion In Organ Transplantation 2023, 28: 126-132. PMID: 36787238, PMCID: PMC10214011, DOI: 10.1097/mot.0000000000001052.
- Gunasekaran D, Pell J, Menon M. Walking the Line Between Antidonor and Antiviral Immunity: A Potential Role for Belatacept. Kidney International Reports 2022, 8: 1-3. PMID: 36644356, PMCID: PMC9832058, DOI: 10.1016/j.ekir.2022.11.005.
- Sun Z, Zhang Z, Banu K, Al Azzi Y, Reghuvaran A, Fredericks S, Planoutene M, Hartzell S, Kim Y, Pell J, Tietjen G, Asch W, Kulkarni S, Formica R, Rana M, Maltzman JS, Zhang W, Akalin E, Heeger PS, Cravedi P, Menon MC. Blood Transcriptomes of SARS-CoV-2–Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity. Journal Of The American Society Of Nephrology 2022, 33: 2108-2122. PMID: 36041788, PMCID: PMC9678030, DOI: 10.1681/asn.2022010125.
- Pell J, Reghuvaran A, Nagata S, Banu K, Shi H, Chernova I, Ishibe S, Menon M. A Novel Role of APOL1 Risk-Alleles in T-Cell Activation and Focal Segmental Glomerulosclerosis. Journal Of The American Society Of Nephrology 2022, 33: 410-411. DOI: 10.1681/asn.20223311s1410d.
- Hricik D, Armstrong B, Alhamad T, Brennan D, Bromberg J, Bunnapradist S, Chandran S, Fairchild R, Foley D, Formica R, Gibson I, Kesler K, Kim SJ, Mannon R, Menon M, Newell K, Nickerson P, Odim J, Poggio E, Sung R, Shapiro R, Tinckam K, Vincenti F, Heeger P. Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial. Journal Of The American Society Of Nephrology 2022, 34: 145-159. PMID: 36195441, PMCID: PMC10101585, DOI: 10.1681/asn.2022040454.
- Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.
- Jethwani P, Rao A, Bow L, Menon MC. Donor–Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms. Frontiers In Immunology 2022, 13: 822353. PMID: 35432337, PMCID: PMC9012490, DOI: 10.3389/fimmu.2022.822353.
- Zhang Z, Sun Z, Fu J, Lin Q, Banu K, Chauhan K, Planoutene M, Wei C, Salem F, Yi Z, Liu R, Cravedi P, Cheng H, Hao K, O’Connell P, Ishibe S, Zhang W, Coca SG, Gibson IW, Colvin RB, He J, Heeger PS, Murphy B, Menon MC. Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes. Journal Of Clinical Investigation 2021, 131 PMID: 34499625, PMCID: PMC8592534, DOI: 10.1172/jci146643.
- Yi Z, Salem F, Menon MC, Keung K, Xi C, Hultin S, Haroon Al Rasheed MR, Li L, Su F, Sun Z, Wei C, Huang W, Fredericks S, Lin Q, Banu K, Wong G, Rogers NM, Farouk S, Cravedi P, Shingde M, Smith RN, Rosales IA, O'Connell PJ, Colvin RB, Murphy B, Zhang W. Deep learning identified pathological abnormalities predictive of graft loss in kidney transplant biopsies. Kidney International 2021, 101: 288-298. PMID: 34757124, PMCID: PMC10285669, DOI: 10.1016/j.kint.2021.09.028.
- Banu K, Lin Q, Basgen JM, Planoutene M, Wei C, Reghuvaran AC, Tian X, Shi H, Garzon F, Garzia A, Chun N, Cumpelik A, Santeusanio AD, Zhang W, Das B, Salem F, LI L, Ishibe S, Cantley LG, Kaufman L, Lemley KV, Ni Z, He JC, Murphy B, Menon MC. AMP-Kinase mediates regulation of glomerular volume and podocyte survival. JCI Insight 2021, 6: e150004. PMID: 34473647, PMCID: PMC8525649, DOI: 10.1172/jci.insight.150004.
- Yi Z, Salem F, Menon M, Xi C, Hultin S, Al Rasheed M, Li L, Sun Z, Wei C, Huang W, Fredericks S, Banu K, Wong G, Farouk S, Cravedi P, Shingde M, O'Connell P, Colvin R, Murphy B, Zhang W. Deep Learning Identifies Pathological Abnormalities Predictive of Graft Loss in Kidney Transplant Biopsies. Journal Of The American Society Of Nephrology 2021, 32: 681-681. DOI: 10.1681/asn.20213210s1681c.
- Lin Q, Banu K, Reghuvaran A, Wei C, He J, Murphy B, Menon M. ROCK-Binding ASD2-Domain of Shroom3 Has a Profibrotic Role. Journal Of The American Society Of Nephrology 2021, 32: 754-754. DOI: 10.1681/asn.20213210s1754a.
- Zhang W, Yi Z, Wei C, Xi C, Huang W, Sun Z, Farouk S, Cravedi P, Menon M, Colvin R, O'Connell P, Murphy B. A Peripheral Blood Transcriptomic Signature Predicts the Progression of Chronic Kidney Damage Post Transplant. Journal Of The American Society Of Nephrology 2021, 32: 627-627. DOI: 10.1681/asn.20213210s1627a.
- Banu K, Basgen J, Lin Q, Cumpelik A, Kaufman L, Planoutene M, Murphy B, He J, Menon M. Shroom3-FYN Regulates Podometrics via LKB1-AMPK Signaling. Journal Of The American Society Of Nephrology 2020, 31: 610-610. DOI: 10.1681/asn.20203110s1610a.
- Tang T, Lu B, Rogers N, Zheng G, Nicholson L, Cao Q, Menon M, Murphy B, Alexander S, Hu M, O’connell P. A POINT MUTATION OF SHROOM3 PROMOTES CD206+ MACROPHAGE INFILTRATION AND KIDNEY FIBROSIS AFTER ISCHEMIA-REPERFUSION INJURY. Transplantation 2020, 104: s166-s167. DOI: 10.1097/01.tp.0000699188.09671.c3.
- Kennedy P, Bane O, Hectors SJ, Gordic S, Berger M, Delaney V, Salem F, Lewis S, Menon M, Taouli B. Magnetic resonance elastography vs. point shear wave ultrasound elastography for the assessment of renal allograft dysfunction. European Journal Of Radiology 2020, 130: 109180. PMID: 32736305, DOI: 10.1016/j.ejrad.2020.109180.
- Zhang Z, Menon MC, Zhang W, Stahl E, Loza BL, Rosales IA, Yi Z, Banu K, Garzon F, Sun Z, Wei C, Huang W, Lin Q, Israni A, Keating BJ, Colvin RB, Hao K, Murphy B. Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis. Kidney International 2020, 98: 758-768. PMID: 32454123, PMCID: PMC7483801, DOI: 10.1016/j.kint.2020.04.039.
- Bane O, Hectors S, Gordic S, Kennedy P, Wagner M, Weiss A, Khaim R, Yi Z, Zhang W, Delaney V, Salem F, He C, Menon MC, Lewis S, Taouli B. Multiparametric magnetic resonance imaging shows promising results to assess renal transplant dysfunction with fibrosis. Kidney International 2019, 97: 414-420. PMID: 31874802, PMCID: PMC6983343, DOI: 10.1016/j.kint.2019.09.030.
- Zhang W, Yi Z, Keung KL, Shang H, Wei C, Cravedi P, Sun Z, Xi C, Woytovich C, Farouk S, Huang W, Banu K, Gallon L, Magee CN, Najafian N, Samaniego M, Djamali A, Alexander SI, Rosales IA, Smith RN, Xiang J, Lerut E, Kuypers D, Naesens M, O'Connell PJ, Colvin R, Menon MC, Murphy B. A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection. Journal Of The American Society Of Nephrology 2019, 30: 1481-1494. PMID: 31278196, PMCID: PMC6683710, DOI: 10.1681/asn.2018111098.
- Wei C, Banu K, Garzon F, Basgen JM, Philippe N, Yi Z, Liu R, Choudhuri J, Fribourg M, Liu T, Cumpelik A, Wong J, Khan M, Das B, Keung K, Salem F, Campbell KN, Kaufman L, Cravedi P, Zhang W, O'Connell PJ, He JC, Murphy B, Menon MC. SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts. Journal Of The American Society Of Nephrology 2018, 29: 2641-2657. PMID: 30341149, PMCID: PMC6218856, DOI: 10.1681/asn.2018060573.
- Yacoub R, Nadkarni GN, Cravedi P, He JC, Delaney VB, Kent R, Chauhan KN, Coca SG, Florman SS, Heeger PS, Murphy B, Menon MC. Analysis of OPTN/UNOS registry suggests the number of HLA matches and not mismatches is a stronger independent predictor of kidney transplant survival. Kidney International 2017, 93: 482-490. PMID: 28965746, DOI: 10.1016/j.kint.2017.07.016.
- Zhang Z, Hao K, Ross MJ, Murphy B, Menon MC. APOL1 G2 risk allele—clarifying nomenclature. Kidney International 2017, 92: 518-519. PMID: 28709608, DOI: 10.1016/j.kint.2017.05.009.
- O'Connell PJ, Zhang W, Menon MC, Yi Z, Schröppel B, Gallon L, Luan Y, Rosales IA, Ge Y, Losic B, Xi C, Woytovich C, Keung KL, Wei C, Greene I, Overbey J, Bagiella E, Najafian N, Samaniego M, Djamali A, Alexander SI, Nankivell BJ, Chapman JR, Smith RN, Colvin R, Murphy B. Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study. The Lancet 2016, 388: 983-993. PMID: 27452608, PMCID: PMC5014570, DOI: 10.1016/s0140-6736(16)30826-1.
- Patel A, Nadkarni G, Mahajan A, Konstantinidis I, Simoes P, Benjo A, Kumar Agarwal S, Pakanati K, Menon M, Annapureddy N. Temporal Trends of Mortality in Acute Ischemic Stroke in Systemic Lupus Erythematosus: A Propensity-Matched Analysis of Nationwide Inpatient Data (P2.295). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p2.295.
- Menon MC, Chuang PY, Li Z, Wei C, Zhang W, Luan Y, Yi Z, Xiong H, Woytovich C, Greene I, Overbey J, Rosales I, Bagiella E, Chen R, Ma M, Li L, Ding W, Djamali A, Saminego M, O’Connell P, Gallon L, Colvin R, Schroppel B, He JC, Murphy B. Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis. Journal Of Clinical Investigation 2014, 125: 208-221. PMID: 25437874, PMCID: PMC4382250, DOI: 10.1172/jci76902.
Departments and Programs
Biography
Madhav Menon, MD, is a nephrologist who specializes in kidney-related conditions, including chronic kidney disease and caring for patients in need of kidney transplant. He also treats kidney fibrosis (internal scar tissue) and nephrotic syndrome (excessive protein loss in urine).
As an associate professor at Yale School of Medicine, Dr. Menon researches the effects of certain genetic variants on kidney function and potential therapeutic strategies to improve patient outcomes, including with transplant.
Dr. Menon received his medical training from Calicut University and completed his residency in internal medicine at the State University of New York, Upstate Medical University. He further pursued fellowships in nephrology and kidney pancreas transplantation at the Icahn School of Medicine at Mount Sinai.
Titles
- Associate Professor
- Director of Research in Kidney Transplantation, Nephrology
- Steering committee member, Human and Translational Immunology Program
Education & Training
- FellowshipRecanati-Miller Transplant institute at Mount Sinai (2014)
- Post doctoral FellowshipIcahn School of Medicine at Mount Sinai (2013)
- FellowshipIcahn School of Medicine at Mount Sinai (2012)
- ResidencyState University of New York, Upstate Medical University (2010)
- Chief ResidencyPGIMER (2006)
- MDPGIMER, Internal Medicine (2006)
- MBBSCalicut University (2002)
Additional Information
Honors & Recognitions
- Blavatnik accelarator award: Yale ventures (2024)
- Elected to the American Society of Clinical Investigation: American Society of Clinical Investigation (2024)
- International Society of Nephrology- Kidney International Early career researcher Award: International Society of Nephrology (2021)
- AST Award for Achievement in Basic Science, Early Career: American Society of Transplantation (2020)
- Harold and Lamport Golden Clinical Research Award: Icahn School of Medicine at Mount Sinai (2019)
- New Investigator Award: American Heart Association, Council on Kidney and Cardiovascular disease (2017)
- Young Investigator Award: American Heart Association, Council on Kidney and Cardiovascular disease (2016)
- Young Investigator Award: American Society of Transplantation, and The Transplantation Society (2014)
- Ben J Lipps Fellowship Award: American Society of Nephrology (2012)
- Williams J Williams Award: Medicine, State University of New York, Syracuse for "Clinical acumen, Professionalism and teaching ability." (2010)
Professional Service
- NIH NIAID Study section (2024 - 2027): Immunobiology of Transplantation and Alloimmunity
- American society of Nephrology (2024 - 2027): Editorial board for all ASN journals JASN, CJASN, Kidney-360
- American Society of Transplantation (2021 - 2023): Scientific Review Committee
- Dutch Kidney Foundation (2021 - Present): Grant Reviewer
- Medical research Council, UK (2019): Grant Reviewer
- Hongkong-China Medical Research Foundation (2019): Grant Reviewer
- Agence nationale de la recherche, France (2019 - Present): Grant Reviewer
- Clinical Transplantation, Wiley Publishers (2019 - Present): Associate Editor
- Journal of the American Society of Nephrology (2018 - 2021): Editorial Fellow, Transplantation
Publications
- Chutani A, Guevara-Pineda D, Lerner G, Menon M. Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies. Transplant International 2024, 37: 13365. PMID: 39640250, PMCID: PMC11617188, DOI: 10.3389/ti.2024.13365.
- Reghuvaran A, Kumar A, Barsotti G, Pell J, Tanvir E, He J, Menon M. Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024qmq3drgr. DOI: 10.1681/asn.2024qmq3drgr.
- Zhang Z, Sun Z, Heeger P, Menon M. Genetic ancestry, proportion of African ancestry, and apolipoprotein L1 risk variants in kidney recipients. American Journal Of Transplantation 2024, 24: 1710-1712. PMID: 38734416, DOI: 10.1016/j.ajt.2024.05.004.
- Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.
- Cravedi P, Riella L, Ford M, Valujskikh A, Menon M, Kirk A, Alegre M, Alessandrini A, Feng S, Kehn P, Najafian N, Hancock W, Heeger P, Maltzman J, Mannon R, Nadig S, Odim J, Turnquist H, Shaw J, West L, Luo X, Chong A, Bromberg J, group A. Advancing mouse models for transplantation research. American Journal Of Transplantation 2024, 24: 1362-1368. PMID: 38219866, DOI: 10.1016/j.ajt.2024.01.006.
- Yi Z, Xi C, Menon M, Cravedi P, Tedla F, Soto A, Sun Z, Liu K, Zhang J, Wei C, Chen M, Wang W, Veremis B, Garcia-Barros M, Kumar A, Haakinson D, Brody R, Azeloglu E, Gallon L, O'Connell P, Naesens M, Shapiro R, Colvin R, Ward S, Salem F, Zhang W. A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization. Kidney International 2023, 105: 281-292. PMID: 37923131, PMCID: PMC10892475, DOI: 10.1016/j.kint.2023.09.031.
- Sun Z, Zhang Z, Banu K, Gibson I, Colvin R, Yi Z, Zhang W, De Kumar B, Reghuvaran A, Pell J, Manes T, Djamali A, Gallon L, O'Connell P, He J, Pober J, Heeger P, Menon M. Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival. Journal Of Clinical Investigation 2023, 133: e170420. PMID: 37676733, PMCID: PMC10617779, DOI: 10.1172/jci170420.
- Pell J, Nagata S, Menon M. Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm. Kidney360 2023, 4: e1325-e1331. PMID: 37461136, PMCID: PMC10550003, DOI: 10.34067/kid.0000000000000216.
- Chen M, Menon M, Wang W, Fu J, Yi Z, Sun Z, Liu J, Li Z, Mou L, Banu K, Lee S, Dai Y, Anandakrishnan N, Azeloglu E, Lee K, Zhang W, Das B, He J, Wei C. HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy. Nature Communications 2023, 14: 4297. PMID: 37463911, PMCID: PMC10354075, DOI: 10.1038/s41467-023-40086-3.
- Reghuvaran A, Lin Q, Basgen J, Banu K, Shi H, Vashist A, Pell J, Perinchery S, He J, Moledina D, Wilson F, Menon M. Comparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruli. Physiological Reports 2023, 11: e15688. PMID: 37423891, PMCID: PMC10329935, DOI: 10.14814/phy2.15688.
- Bane O, Feng L, Xia D, Al-Mubarak H, Cuevas J, Muthukumar T, Dyke J, Menon M, Farouk S, Taouli B, Lewis S. Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) MRI for Rapid Free-Breathing 3D T1 Mapping of Renal Allografts. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/1286.
- Pell J, Reghuvaran A, Nagata S, Banu K, He J, Craft J, Shi H, Chernova I, Ishibe S, Menon M. WCN23-0470 BAC-transgenic mice show a novel T-cell intrinsic role for FSGS-associated APOL1 risk-variants in T-cell activation. Kidney International Reports 2023, 8: s392-s393. DOI: 10.1016/j.ekir.2023.02.882.
- Virmani S, Rao A, Menon M. Allograft tissue under the microscope: only the beginning. Current Opinion In Organ Transplantation 2023, 28: 126-132. PMID: 36787238, PMCID: PMC10214011, DOI: 10.1097/mot.0000000000001052.
- Gunasekaran D, Pell J, Menon M. Walking the Line Between Antidonor and Antiviral Immunity: A Potential Role for Belatacept. Kidney International Reports 2022, 8: 1-3. PMID: 36644356, PMCID: PMC9832058, DOI: 10.1016/j.ekir.2022.11.005.
- Sun Z, Zhang Z, Banu K, Al Azzi Y, Reghuvaran A, Fredericks S, Planoutene M, Hartzell S, Kim Y, Pell J, Tietjen G, Asch W, Kulkarni S, Formica R, Rana M, Maltzman JS, Zhang W, Akalin E, Heeger PS, Cravedi P, Menon MC. Blood Transcriptomes of SARS-CoV-2–Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity. Journal Of The American Society Of Nephrology 2022, 33: 2108-2122. PMID: 36041788, PMCID: PMC9678030, DOI: 10.1681/asn.2022010125.
- Pell J, Reghuvaran A, Nagata S, Banu K, Shi H, Chernova I, Ishibe S, Menon M. A Novel Role of APOL1 Risk-Alleles in T-Cell Activation and Focal Segmental Glomerulosclerosis. Journal Of The American Society Of Nephrology 2022, 33: 410-411. DOI: 10.1681/asn.20223311s1410d.
- Hricik D, Armstrong B, Alhamad T, Brennan D, Bromberg J, Bunnapradist S, Chandran S, Fairchild R, Foley D, Formica R, Gibson I, Kesler K, Kim SJ, Mannon R, Menon M, Newell K, Nickerson P, Odim J, Poggio E, Sung R, Shapiro R, Tinckam K, Vincenti F, Heeger P. Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial. Journal Of The American Society Of Nephrology 2022, 34: 145-159. PMID: 36195441, PMCID: PMC10101585, DOI: 10.1681/asn.2022040454.
- Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.
- Jethwani P, Rao A, Bow L, Menon MC. Donor–Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms. Frontiers In Immunology 2022, 13: 822353. PMID: 35432337, PMCID: PMC9012490, DOI: 10.3389/fimmu.2022.822353.
- Zhang Z, Sun Z, Fu J, Lin Q, Banu K, Chauhan K, Planoutene M, Wei C, Salem F, Yi Z, Liu R, Cravedi P, Cheng H, Hao K, O’Connell P, Ishibe S, Zhang W, Coca SG, Gibson IW, Colvin RB, He J, Heeger PS, Murphy B, Menon MC. Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes. Journal Of Clinical Investigation 2021, 131 PMID: 34499625, PMCID: PMC8592534, DOI: 10.1172/jci146643.
- Yi Z, Salem F, Menon MC, Keung K, Xi C, Hultin S, Haroon Al Rasheed MR, Li L, Su F, Sun Z, Wei C, Huang W, Fredericks S, Lin Q, Banu K, Wong G, Rogers NM, Farouk S, Cravedi P, Shingde M, Smith RN, Rosales IA, O'Connell PJ, Colvin RB, Murphy B, Zhang W. Deep learning identified pathological abnormalities predictive of graft loss in kidney transplant biopsies. Kidney International 2021, 101: 288-298. PMID: 34757124, PMCID: PMC10285669, DOI: 10.1016/j.kint.2021.09.028.
- Banu K, Lin Q, Basgen JM, Planoutene M, Wei C, Reghuvaran AC, Tian X, Shi H, Garzon F, Garzia A, Chun N, Cumpelik A, Santeusanio AD, Zhang W, Das B, Salem F, LI L, Ishibe S, Cantley LG, Kaufman L, Lemley KV, Ni Z, He JC, Murphy B, Menon MC. AMP-Kinase mediates regulation of glomerular volume and podocyte survival. JCI Insight 2021, 6: e150004. PMID: 34473647, PMCID: PMC8525649, DOI: 10.1172/jci.insight.150004.
- Yi Z, Salem F, Menon M, Xi C, Hultin S, Al Rasheed M, Li L, Sun Z, Wei C, Huang W, Fredericks S, Banu K, Wong G, Farouk S, Cravedi P, Shingde M, O'Connell P, Colvin R, Murphy B, Zhang W. Deep Learning Identifies Pathological Abnormalities Predictive of Graft Loss in Kidney Transplant Biopsies. Journal Of The American Society Of Nephrology 2021, 32: 681-681. DOI: 10.1681/asn.20213210s1681c.
- Lin Q, Banu K, Reghuvaran A, Wei C, He J, Murphy B, Menon M. ROCK-Binding ASD2-Domain of Shroom3 Has a Profibrotic Role. Journal Of The American Society Of Nephrology 2021, 32: 754-754. DOI: 10.1681/asn.20213210s1754a.
- Zhang W, Yi Z, Wei C, Xi C, Huang W, Sun Z, Farouk S, Cravedi P, Menon M, Colvin R, O'Connell P, Murphy B. A Peripheral Blood Transcriptomic Signature Predicts the Progression of Chronic Kidney Damage Post Transplant. Journal Of The American Society Of Nephrology 2021, 32: 627-627. DOI: 10.1681/asn.20213210s1627a.
- Banu K, Basgen J, Lin Q, Cumpelik A, Kaufman L, Planoutene M, Murphy B, He J, Menon M. Shroom3-FYN Regulates Podometrics via LKB1-AMPK Signaling. Journal Of The American Society Of Nephrology 2020, 31: 610-610. DOI: 10.1681/asn.20203110s1610a.
- Tang T, Lu B, Rogers N, Zheng G, Nicholson L, Cao Q, Menon M, Murphy B, Alexander S, Hu M, O’connell P. A POINT MUTATION OF SHROOM3 PROMOTES CD206+ MACROPHAGE INFILTRATION AND KIDNEY FIBROSIS AFTER ISCHEMIA-REPERFUSION INJURY. Transplantation 2020, 104: s166-s167. DOI: 10.1097/01.tp.0000699188.09671.c3.
- Kennedy P, Bane O, Hectors SJ, Gordic S, Berger M, Delaney V, Salem F, Lewis S, Menon M, Taouli B. Magnetic resonance elastography vs. point shear wave ultrasound elastography for the assessment of renal allograft dysfunction. European Journal Of Radiology 2020, 130: 109180. PMID: 32736305, DOI: 10.1016/j.ejrad.2020.109180.
- Zhang Z, Menon MC, Zhang W, Stahl E, Loza BL, Rosales IA, Yi Z, Banu K, Garzon F, Sun Z, Wei C, Huang W, Lin Q, Israni A, Keating BJ, Colvin RB, Hao K, Murphy B. Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis. Kidney International 2020, 98: 758-768. PMID: 32454123, PMCID: PMC7483801, DOI: 10.1016/j.kint.2020.04.039.
- Bane O, Hectors S, Gordic S, Kennedy P, Wagner M, Weiss A, Khaim R, Yi Z, Zhang W, Delaney V, Salem F, He C, Menon MC, Lewis S, Taouli B. Multiparametric magnetic resonance imaging shows promising results to assess renal transplant dysfunction with fibrosis. Kidney International 2019, 97: 414-420. PMID: 31874802, PMCID: PMC6983343, DOI: 10.1016/j.kint.2019.09.030.
- Zhang W, Yi Z, Keung KL, Shang H, Wei C, Cravedi P, Sun Z, Xi C, Woytovich C, Farouk S, Huang W, Banu K, Gallon L, Magee CN, Najafian N, Samaniego M, Djamali A, Alexander SI, Rosales IA, Smith RN, Xiang J, Lerut E, Kuypers D, Naesens M, O'Connell PJ, Colvin R, Menon MC, Murphy B. A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection. Journal Of The American Society Of Nephrology 2019, 30: 1481-1494. PMID: 31278196, PMCID: PMC6683710, DOI: 10.1681/asn.2018111098.
- Wei C, Banu K, Garzon F, Basgen JM, Philippe N, Yi Z, Liu R, Choudhuri J, Fribourg M, Liu T, Cumpelik A, Wong J, Khan M, Das B, Keung K, Salem F, Campbell KN, Kaufman L, Cravedi P, Zhang W, O'Connell PJ, He JC, Murphy B, Menon MC. SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts. Journal Of The American Society Of Nephrology 2018, 29: 2641-2657. PMID: 30341149, PMCID: PMC6218856, DOI: 10.1681/asn.2018060573.
- Yacoub R, Nadkarni GN, Cravedi P, He JC, Delaney VB, Kent R, Chauhan KN, Coca SG, Florman SS, Heeger PS, Murphy B, Menon MC. Analysis of OPTN/UNOS registry suggests the number of HLA matches and not mismatches is a stronger independent predictor of kidney transplant survival. Kidney International 2017, 93: 482-490. PMID: 28965746, DOI: 10.1016/j.kint.2017.07.016.
- Zhang Z, Hao K, Ross MJ, Murphy B, Menon MC. APOL1 G2 risk allele—clarifying nomenclature. Kidney International 2017, 92: 518-519. PMID: 28709608, DOI: 10.1016/j.kint.2017.05.009.
- O'Connell PJ, Zhang W, Menon MC, Yi Z, Schröppel B, Gallon L, Luan Y, Rosales IA, Ge Y, Losic B, Xi C, Woytovich C, Keung KL, Wei C, Greene I, Overbey J, Bagiella E, Najafian N, Samaniego M, Djamali A, Alexander SI, Nankivell BJ, Chapman JR, Smith RN, Colvin R, Murphy B. Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study. The Lancet 2016, 388: 983-993. PMID: 27452608, PMCID: PMC5014570, DOI: 10.1016/s0140-6736(16)30826-1.
- Patel A, Nadkarni G, Mahajan A, Konstantinidis I, Simoes P, Benjo A, Kumar Agarwal S, Pakanati K, Menon M, Annapureddy N. Temporal Trends of Mortality in Acute Ischemic Stroke in Systemic Lupus Erythematosus: A Propensity-Matched Analysis of Nationwide Inpatient Data (P2.295). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p2.295.
- Menon MC, Chuang PY, Li Z, Wei C, Zhang W, Luan Y, Yi Z, Xiong H, Woytovich C, Greene I, Overbey J, Rosales I, Bagiella E, Chen R, Ma M, Li L, Ding W, Djamali A, Saminego M, O’Connell P, Gallon L, Colvin R, Schroppel B, He JC, Murphy B. Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis. Journal Of Clinical Investigation 2014, 125: 208-221. PMID: 25437874, PMCID: PMC4382250, DOI: 10.1172/jci76902.
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