- Yale NeonatologyYale New Haven Children's Hospital1 Park Street, Ste West Pavilion - 2nd FloorNew Haven, CT 06504
Jeffrey R Gruen, MD
Biography
Jeffrey R. Gruen, MD, is a pediatrician specializing in disorders in newborn babies. He treats conditions that typically result from prematurity, congenital genetic disorders, inborn metabolic errors and infections.
In addition to his clinical work, Dr. Gruen has been the principal investigator in a number of notable studies of the genetics of reading disability (dyslexia) and language impairment. “My work focuses on learning disabilities such as dyslexia, language impairment and speech-sound disorder,” he says.
A professor of pediatrics (neonatology) and of genetics at Yale School of Medicine, Dr. Gruen is also a member of the Investigative Medicine Program, a PhD program at Yale School of Medicine. He is an investigator in the Learning Disabilities Research Center at the University of Colorado, Boulder; and a member of the Learning Disabilities Research Centers Consortium funded by the National Institutes of Health.
Titles
- Professor of Pediatrics (Neonatology) and of Genetics
- Faculty, Investigative Medicine Program, Yale Graduate School of Arts and Sciences
Education & Training
- FellowYale University School of Medicine, New Haven, CT (1988)
- ResidentYale-New Haven Hospital, New Haven, CT (1984)
- InternPediatrics, Yale-New Haven Hospital, New Haven, CT (1982)
- MDTulane University (1981)
- BSTulane University, Chemistry (1977)
Additional Information
- Innovative Research Award: Kavli Institute (2022)
- AB of Pediatrics, Pediatrics (1986)
- Li M, DeMille M, Lovett M, Bosson-Heenan J, Frijters J, Gruen J. Phonological awareness mediates the relationship between DCDC2 and reading performance with home environment. Npj Science Of Learning 2024, 9: 36. PMID: 38702345, PMCID: PMC11068914, DOI: 10.1038/s41539-024-00247-5.
- Petrill S, Klamer B, Buyske S, Willcutt E, Gruen J, Francis D, Flax J, Brzustowicz L, Bartlett C. The Rosetta Phenotype Harmonization Method Facilitates Finding a Relationship Quantitative Trait Locus for a Complex Cognitive Trait. Genes 2023, 14: 1748. PMID: 37761888, PMCID: PMC10531321, DOI: 10.3390/genes14091748.
- Doust C, Fontanillas P, Eising E, Gordon SD, Wang Z, Alagöz G, Molz B, Pourcain B, Francks C, Marioni R, Zhao J, Paracchini S, Talcott J, Monaco A, Stein J, Gruen J, Olson R, Willcutt E, DeFries J, Pennington B, Smith S, Wright M, Martin N, Auton A, Bates T, Fisher S, Luciano M. Discovery of 42 genome-wide significant loci associated with dyslexia. Nature Genetics 2022, 54: 1621-1629. PMID: 36266505, PMCID: PMC9649434, DOI: 10.1038/s41588-022-01192-y.
- Gabel L, Battison A, Truong D, Lindström E, Voss K, Yu Y, Roongruengratanakul S, Shyntassov K, Riebesell S, Toumanios N, Nielsen-Pheiffer C, Paniagua S, Gruen J. Orthographic Depth May Influence the Degree of Severity of Maze Learning Performance in Children at Risk for Reading Disorder. Developmental Neuroscience 2022, 44: 651-670. PMID: 36223729, PMCID: PMC9928771, DOI: 10.1159/000527480.
- Prosnitz A, Gruen J, Bhandari V. 7 The Genetics of Disorders Affecting the Premature Newborn. 2022, 149-185. DOI: 10.1016/b978-0-12-815236-2.00006-0.
- Adams AK, Smith SD, Truong DT, Willcutt EG, Olson RK, DeFries JC, Pennington BF, Gruen JR. Enrichment of putatively damaging rare variants in the DYX2 locus and the reading-related genes CCDC136 and FLNC. Human Genetics 2017, 136: 1395-1405. PMID: 28866788, PMCID: PMC5702371, DOI: 10.1007/s00439-017-1838-z.
- Frijters JC, Tsujimoto KC, Boada R, Gottwald S, Hill D, Jacobson LA, Lovett MW, Mahone EM, Willcutt EG, Wolf M, Bosson‐Heenan J, Gruen JR. Reading‐Related Causal Attributions for Success and Failure: Dynamic Links With Reading Skill. Reading Research Quarterly 2017, 53: 127-148. PMID: 29391653, PMCID: PMC5788039, DOI: 10.1002/rrq.189.
- Truong DT, Shriberg LD, Smith SD, Chapman KL, Scheer-Cohen AR, DeMille MM, Adams AK, Nato AQ, Wijsman EM, Eicher JD, Gruen JR. Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders. Human Genetics 2016, 135: 1329-1341. PMID: 27535846, PMCID: PMC5065602, DOI: 10.1007/s00439-016-1717-z.
- Jacobson LA, Koriakin T, Lipkin P, Boada R, Frijters JC, Lovett MW, Hill D, Willcutt E, Gottwald S, Wolf M, Bosson-Heenan J, Gruen JR, Mahone EM. Executive Functions Contribute Uniquely to Reading Competence in Minority Youth. Journal Of Learning Disabilities 2016, 50: 422-433. PMID: 26755569, PMCID: PMC5960349, DOI: 10.1177/0022219415618501.
- Powers N, Eicher J, Butter F, Kong Y, Miller L, Ring S, Mann M, Gruen J. Alleles of a Polymorphic ETV6 Binding Site in DCDC2 Confer Risk of Reading and Language Impairment. American Journal Of Human Genetics 2014, 94: 798. PMCID: PMC4067563, DOI: 10.1016/j.ajhg.2014.04.001.
- Prosnitz A, Gruen J, Bhandari V. The Genetics of Disorders Affecting the Premature Newborn. 2014 DOI: 10.1016/b978-0-12-801238-3.05514-8.
- Hoda K, Bowlus C, Chu T, Gruen J. Iron Metabolism and Related Disorders. 2014 DOI: 10.1016/b978-0-12-801238-3.05573-2.
- Eicher JD, Powers NR, Miller LL, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst T, Frazier J, Kaufmann WE, Keating B, Kenet T, Kennedy D, Mostofsky S, Murray SS, Sowell ER, Bartsch H, Kuperman JM, Brown TT, Hagler DJ, Dale AM, Jernigan TL, St. Pourcain B, Smith G, Ring SM, Gruen JR, for the Pediatric Imaging N. Genome‐wide association study of shared components of reading disability and language impairment. Genes Brain & Behavior 2013, 12: 792-801. PMID: 24024963, PMCID: PMC3904347, DOI: 10.1111/gbb.12085.
- Eicher JD, Gruen JR. Imaging-genetics in dyslexia: Connecting risk genetic variants to brain neuroimaging and ultimately to reading impairments. Molecular Genetics And Metabolism 2013, 110: 201-212. PMID: 23916419, PMCID: PMC3800223, DOI: 10.1016/j.ymgme.2013.07.001.
- Powers NR, Eicher JD, Butter F, Kong Y, Miller LL, Ring SM, Mann M, Gruen JR. Alleles of a Polymorphic ETV6 Binding Site in DCDC2 Confer Risk of Reading and Language Impairment. American Journal Of Human Genetics 2013, 93: 19-28. PMID: 23746548, PMCID: PMC3710765, DOI: 10.1016/j.ajhg.2013.05.008.
- Eicher JD, Powers NR, Cho K, Miller LL, Mueller KL, Ring SM, Tomblin JB, Gruen JR. Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language. PLOS ONE 2013, 8: e63762. PMID: 23691092, PMCID: PMC3655151, DOI: 10.1371/journal.pone.0063762.
- Eicher J, Powers N, Gruen J. Genome‐wide association studies of severe communication processes and affectation of multiple prevalent pediatric communication disorders. The FASEB Journal 2013, 27: 533.5-533.5. DOI: 10.1096/fasebj.27.1_supplement.533.5.
- Prosnitz A, Gruen J, Bhandari V. Chapter 41 The Genetics of Disorders Affecting the Premature Newborn. 2013, 1-22. DOI: 10.1016/b978-0-12-383834-6.00171-3.
- Hoda K, Bowlus C, Chu T, Gruen J. Chapter 101 Iron Metabolism and Related Disorders. 2013, 1-41. DOI: 10.1016/b978-0-12-383834-6.00106-3.
- Cho K, Frijters JC, Zhang H, Miller LL, Gruen JR. Prenatal Exposure to Nicotine and Impaired Reading Performance. The Journal Of Pediatrics 2012, 162: 713-718.e2. PMID: 23122624, PMCID: PMC3577994, DOI: 10.1016/j.jpeds.2012.09.041.
- Cope N, Eicher JD, Meng H, Gibson CJ, Hager K, Lacadie C, Fulbright RK, Constable RT, Page GP, Gruen JR. Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability. NeuroImage 2012, 63: 148-156. PMID: 22750057, PMCID: PMC3518451, DOI: 10.1016/j.neuroimage.2012.06.037.
- Marino C, Meng H, Mascheretti S, Rusconi M, Cope N, Giorda R, Molteni M, Gruen JR. DCDC2 genetic variants and susceptibility to developmental dyslexia. Psychiatric Genetics 2012, 22: 25-30. PMID: 21881542, PMCID: PMC3232293, DOI: 10.1097/ypg.0b013e32834acdb2.
- Rivkees S, Hager K, Hosono S, Wise A, Li P, Rinder H, Gruen J. A Highly Sensitive, High-Throughput Assay for the Detection of Turner Syndrome. Obstetrical & Gynecological Survey 2011, 66: 421-422. DOI: 10.1097/ogx.0b013e3182338c32.
- Meng H, Powers NR, Tang L, Cope NA, Zhang PX, Fuleihan R, Gibson C, Page GP, Gruen JR. A Dyslexia-Associated Variant in DCDC2 Changes Gene Expression. Behavior Genetics 2010, 41: 58-66. PMID: 21042874, PMCID: PMC3053575, DOI: 10.1007/s10519-010-9408-3.
- Bhandari V, Gruen J. The Genomics of Bronchopulmonary Dysplasia. NeoReviews 2007, 8: e336-e344. DOI: 10.1542/neo.8-8-e336.
- Bizzarro M, Hussain N, Jonsson B, Feng R, Ment L, Gruen J, Zhang H, Bhandari V. Genetic susceptibility to retinopathy of prematurity. American Journal Of Ophthalmology 2007, 143: 375-376. DOI: 10.1016/j.ajo.2006.12.016.
- Gruen J. Genetic Polymorphisms of Hemostasis Genes and Primary Outcome of Very Low Birth Weight Infants Härtel C, König I, Köster S, et al (Univ at Lübeck, Germany; Kinderklinik auf der Bult, Hannover, Germany; Olgahospital, Stuttgart, Germany; et al) Pediatrics 118:683–689, 2006§. Yearbook Of Neonatal And Perinatal Medicine 2007, 2007: 63-65. DOI: 10.1016/s8756-5005(08)70041-6.
- Zhang H, Liu L, Wang X, Gruen JR. Guideline for data analysis of genomewide association studies. Cancer Genomics & Proteomics 2007, 4: 27-34. PMID: 17726238.
- Meng H, Gruen JR. Genetic approaches to complications of prematurity. Frontiers In Bioscience-Landmark 2007, 12: 2344-51. PMID: 17127244, DOI: 10.2741/2236.
- Shetty A, Gruen J, Bhandari V. Is There a Genetic Susceptibility to Bronchopulmonary Dysplasia? Current Respiratory Medicine Reviews 2006, 2: 253-262. DOI: 10.2174/157339806778018935.
- Meng H, Smith SD, Hager K, Held M, Liu J, Olson RK, Pennington BF, DeFries JC, Gelernter J, O'Reilly-Pol T, Somlo S, Skudlarski P, Shaywitz SE, Shaywitz BA, Marchione K, Wang Y, Paramasivam M, LoTurco JJ, Page GP, Gruen JR. DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 17053-17058. PMID: 16278297, PMCID: PMC1278934, DOI: 10.1073/pnas.0508591102.
- Ahn J, Won T, Zia A, Reutter H, Kaplan D, Sparks R, Gruen J. Peaks of Linkage Are Localized by a BAC/PAC Contig of the 6p Reading Disability Locus. Genomics 2001, 78: 19-29. PMID: 11707069, DOI: 10.1006/geno.2001.6645.
- Hisama F, Gruen J, Choi J, Huseinovic M, Grigorenko E, Pauls D, Mattson R, Gelernter J, Wood F, Goei V. Human GABAB receptor 1 gene: Eight novel sequence variants. Human Mutation 2001, 17: 349-350. PMID: 11295833, DOI: 10.1002/humu.34.
- Barr C, Feng Y, Wigg K, Roberts W, Malone M, Schachar R, Tannock R, Gruen J, Goei V, Kennedy J. Identification of polymorphisms in theGABAB receptor gene and linkage study of attention-deficit hyperactivity disorder. International Journal Of Genomics 2000, 1: 1-8. DOI: 10.1002/(sici)1438-826x(200012)1:5/6<1::aid-gnfd4>3.0.co;2-8.
- Barr C, Feng Y, Wigg K, Roberts W, Malone M, Schachar R, Tannock R, Gruen J, Goei V, Kennedy J. Identification of polymorphisms in the GABAB receptor gene and linkage study of attention‐deficit hyperactivity disorder. International Journal Of Genomics 2000, 1: 194-201. DOI: 10.1002/1438-826x(200012)1:5/6<194::aid-gnfd194>3.0.co;2-2.
- Raha-Chowdhury R, Gruen J. Localization, allelic heterogeneity, and origins of the hemochromatosis gene. 2000, 75-90. DOI: 10.1017/cbo9780511666476.008.
- Bowlus C, Ahn J, Chu T, Gruen J. Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus. Cellular Immunology 1999, 196: 80-86. PMID: 10527559, DOI: 10.1006/cimm.1999.1543.
- Ahn J, Gruen J. The genomic organization of the histone clusters on human 6p21.3. Mammalian Genome 1999, 10: 768-770. PMID: 10384058, DOI: 10.1007/s003359901089.
- Goei V, Choi J, Ahn J, Bowlus C, Raha-Chowdhury R, Gruen J. Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization. Biological Psychiatry 1998, 44: 659-666. PMID: 9798068, DOI: 10.1016/s0006-3223(98)00244-3.
- Gruen J, Weissman S. Evolving Views of the Major Histocompatibility Complex. Blood 1997, 90: 4252-4265. PMID: 9373235, DOI: 10.1182/blood.v90.11.4252.
- Gruen J, Weissman S. Evolving Views of the Major Histocompatibility Complex. Blood 1997, 90: 4252-4265. DOI: 10.1182/blood.v90.11.4252.4252_4252_4265.
- Ajioka R, Jorde L, Gruen J, Yu P, Dimitrova D, Barrow J, Radisky E, Edwards C, Griffen L, Kushner J. Haplotype Analysis of Hemochromatosis: Evaluation of Different Linkage-Disequilibrium Approaches and Evolution of Disease Chromosomes. American Journal Of Human Genetics 1997, 60: 1439-1447. PMID: 9199565, PMCID: PMC1716127, DOI: 10.1086/515466.
- Weissman S, Nalabolu S, Chu T, Bowles C, Fan W, Goei V, Wei H, Sivakamasundari R, Liu Y, Xu H, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Nallur G, Gruen J. O338 A transcription map of the Major Histocompatibility Complex (MHC) Class I region. Human Immunology 1996, 47: 64. DOI: 10.1016/0198-8859(96)85033-6.
- Chu T, Capossela A, Coleman R, Goei V, Nallur G, Gruen J. Cloning of a New "Finger" Protein Gene (ZNF173) within the Class I Region of the Human MHC. Genomics 1995, 29: 229-239. PMID: 8530076, DOI: 10.1006/geno.1995.1236.
- Gruen J, Goei V, Summers K, Capossela A, Powell L, Halliday J, Zoghbi H, Shukla H, Weissman S. Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE). Genomics 1992, 14: 232-240. PMID: 1427838, DOI: 10.1016/s0888-7543(05)80211-3.
- Swaroop A, Agarwal N, Gruen J, Bick D, Weissman S. Differential expression of novel Gsα signal transduction protein cDNA species. Nucleic Acids Research 1991, 19: 4725-4729. PMID: 1716359, PMCID: PMC328715, DOI: 10.1093/nar/19.17.4725.
- Yale NeonatologyYale New Haven Children's Hospital1 Park Street, Ste West Pavilion - 2nd FloorNew Haven, CT 06504
Biography
Jeffrey R. Gruen, MD, is a pediatrician specializing in disorders in newborn babies. He treats conditions that typically result from prematurity, congenital genetic disorders, inborn metabolic errors and infections.
In addition to his clinical work, Dr. Gruen has been the principal investigator in a number of notable studies of the genetics of reading disability (dyslexia) and language impairment. “My work focuses on learning disabilities such as dyslexia, language impairment and speech-sound disorder,” he says.
A professor of pediatrics (neonatology) and of genetics at Yale School of Medicine, Dr. Gruen is also a member of the Investigative Medicine Program, a PhD program at Yale School of Medicine. He is an investigator in the Learning Disabilities Research Center at the University of Colorado, Boulder; and a member of the Learning Disabilities Research Centers Consortium funded by the National Institutes of Health.
Titles
- Professor of Pediatrics (Neonatology) and of Genetics
- Faculty, Investigative Medicine Program, Yale Graduate School of Arts and Sciences
Education & Training
- FellowYale University School of Medicine, New Haven, CT (1988)
- ResidentYale-New Haven Hospital, New Haven, CT (1984)
- InternPediatrics, Yale-New Haven Hospital, New Haven, CT (1982)
- MDTulane University (1981)
- BSTulane University, Chemistry (1977)
Additional Information
- Innovative Research Award: Kavli Institute (2022)
- AB of Pediatrics, Pediatrics (1986)
- Li M, DeMille M, Lovett M, Bosson-Heenan J, Frijters J, Gruen J. Phonological awareness mediates the relationship between DCDC2 and reading performance with home environment. Npj Science Of Learning 2024, 9: 36. PMID: 38702345, PMCID: PMC11068914, DOI: 10.1038/s41539-024-00247-5.
- Petrill S, Klamer B, Buyske S, Willcutt E, Gruen J, Francis D, Flax J, Brzustowicz L, Bartlett C. The Rosetta Phenotype Harmonization Method Facilitates Finding a Relationship Quantitative Trait Locus for a Complex Cognitive Trait. Genes 2023, 14: 1748. PMID: 37761888, PMCID: PMC10531321, DOI: 10.3390/genes14091748.
- Doust C, Fontanillas P, Eising E, Gordon SD, Wang Z, Alagöz G, Molz B, Pourcain B, Francks C, Marioni R, Zhao J, Paracchini S, Talcott J, Monaco A, Stein J, Gruen J, Olson R, Willcutt E, DeFries J, Pennington B, Smith S, Wright M, Martin N, Auton A, Bates T, Fisher S, Luciano M. Discovery of 42 genome-wide significant loci associated with dyslexia. Nature Genetics 2022, 54: 1621-1629. PMID: 36266505, PMCID: PMC9649434, DOI: 10.1038/s41588-022-01192-y.
- Gabel L, Battison A, Truong D, Lindström E, Voss K, Yu Y, Roongruengratanakul S, Shyntassov K, Riebesell S, Toumanios N, Nielsen-Pheiffer C, Paniagua S, Gruen J. Orthographic Depth May Influence the Degree of Severity of Maze Learning Performance in Children at Risk for Reading Disorder. Developmental Neuroscience 2022, 44: 651-670. PMID: 36223729, PMCID: PMC9928771, DOI: 10.1159/000527480.
- Prosnitz A, Gruen J, Bhandari V. 7 The Genetics of Disorders Affecting the Premature Newborn. 2022, 149-185. DOI: 10.1016/b978-0-12-815236-2.00006-0.
- Adams AK, Smith SD, Truong DT, Willcutt EG, Olson RK, DeFries JC, Pennington BF, Gruen JR. Enrichment of putatively damaging rare variants in the DYX2 locus and the reading-related genes CCDC136 and FLNC. Human Genetics 2017, 136: 1395-1405. PMID: 28866788, PMCID: PMC5702371, DOI: 10.1007/s00439-017-1838-z.
- Frijters JC, Tsujimoto KC, Boada R, Gottwald S, Hill D, Jacobson LA, Lovett MW, Mahone EM, Willcutt EG, Wolf M, Bosson‐Heenan J, Gruen JR. Reading‐Related Causal Attributions for Success and Failure: Dynamic Links With Reading Skill. Reading Research Quarterly 2017, 53: 127-148. PMID: 29391653, PMCID: PMC5788039, DOI: 10.1002/rrq.189.
- Truong DT, Shriberg LD, Smith SD, Chapman KL, Scheer-Cohen AR, DeMille MM, Adams AK, Nato AQ, Wijsman EM, Eicher JD, Gruen JR. Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders. Human Genetics 2016, 135: 1329-1341. PMID: 27535846, PMCID: PMC5065602, DOI: 10.1007/s00439-016-1717-z.
- Jacobson LA, Koriakin T, Lipkin P, Boada R, Frijters JC, Lovett MW, Hill D, Willcutt E, Gottwald S, Wolf M, Bosson-Heenan J, Gruen JR, Mahone EM. Executive Functions Contribute Uniquely to Reading Competence in Minority Youth. Journal Of Learning Disabilities 2016, 50: 422-433. PMID: 26755569, PMCID: PMC5960349, DOI: 10.1177/0022219415618501.
- Powers N, Eicher J, Butter F, Kong Y, Miller L, Ring S, Mann M, Gruen J. Alleles of a Polymorphic ETV6 Binding Site in DCDC2 Confer Risk of Reading and Language Impairment. American Journal Of Human Genetics 2014, 94: 798. PMCID: PMC4067563, DOI: 10.1016/j.ajhg.2014.04.001.
- Prosnitz A, Gruen J, Bhandari V. The Genetics of Disorders Affecting the Premature Newborn. 2014 DOI: 10.1016/b978-0-12-801238-3.05514-8.
- Hoda K, Bowlus C, Chu T, Gruen J. Iron Metabolism and Related Disorders. 2014 DOI: 10.1016/b978-0-12-801238-3.05573-2.
- Eicher JD, Powers NR, Miller LL, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst T, Frazier J, Kaufmann WE, Keating B, Kenet T, Kennedy D, Mostofsky S, Murray SS, Sowell ER, Bartsch H, Kuperman JM, Brown TT, Hagler DJ, Dale AM, Jernigan TL, St. Pourcain B, Smith G, Ring SM, Gruen JR, for the Pediatric Imaging N. Genome‐wide association study of shared components of reading disability and language impairment. Genes Brain & Behavior 2013, 12: 792-801. PMID: 24024963, PMCID: PMC3904347, DOI: 10.1111/gbb.12085.
- Eicher JD, Gruen JR. Imaging-genetics in dyslexia: Connecting risk genetic variants to brain neuroimaging and ultimately to reading impairments. Molecular Genetics And Metabolism 2013, 110: 201-212. PMID: 23916419, PMCID: PMC3800223, DOI: 10.1016/j.ymgme.2013.07.001.
- Powers NR, Eicher JD, Butter F, Kong Y, Miller LL, Ring SM, Mann M, Gruen JR. Alleles of a Polymorphic ETV6 Binding Site in DCDC2 Confer Risk of Reading and Language Impairment. American Journal Of Human Genetics 2013, 93: 19-28. PMID: 23746548, PMCID: PMC3710765, DOI: 10.1016/j.ajhg.2013.05.008.
- Eicher JD, Powers NR, Cho K, Miller LL, Mueller KL, Ring SM, Tomblin JB, Gruen JR. Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language. PLOS ONE 2013, 8: e63762. PMID: 23691092, PMCID: PMC3655151, DOI: 10.1371/journal.pone.0063762.
- Eicher J, Powers N, Gruen J. Genome‐wide association studies of severe communication processes and affectation of multiple prevalent pediatric communication disorders. The FASEB Journal 2013, 27: 533.5-533.5. DOI: 10.1096/fasebj.27.1_supplement.533.5.
- Prosnitz A, Gruen J, Bhandari V. Chapter 41 The Genetics of Disorders Affecting the Premature Newborn. 2013, 1-22. DOI: 10.1016/b978-0-12-383834-6.00171-3.
- Hoda K, Bowlus C, Chu T, Gruen J. Chapter 101 Iron Metabolism and Related Disorders. 2013, 1-41. DOI: 10.1016/b978-0-12-383834-6.00106-3.
- Cho K, Frijters JC, Zhang H, Miller LL, Gruen JR. Prenatal Exposure to Nicotine and Impaired Reading Performance. The Journal Of Pediatrics 2012, 162: 713-718.e2. PMID: 23122624, PMCID: PMC3577994, DOI: 10.1016/j.jpeds.2012.09.041.
- Cope N, Eicher JD, Meng H, Gibson CJ, Hager K, Lacadie C, Fulbright RK, Constable RT, Page GP, Gruen JR. Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability. NeuroImage 2012, 63: 148-156. PMID: 22750057, PMCID: PMC3518451, DOI: 10.1016/j.neuroimage.2012.06.037.
- Marino C, Meng H, Mascheretti S, Rusconi M, Cope N, Giorda R, Molteni M, Gruen JR. DCDC2 genetic variants and susceptibility to developmental dyslexia. Psychiatric Genetics 2012, 22: 25-30. PMID: 21881542, PMCID: PMC3232293, DOI: 10.1097/ypg.0b013e32834acdb2.
- Rivkees S, Hager K, Hosono S, Wise A, Li P, Rinder H, Gruen J. A Highly Sensitive, High-Throughput Assay for the Detection of Turner Syndrome. Obstetrical & Gynecological Survey 2011, 66: 421-422. DOI: 10.1097/ogx.0b013e3182338c32.
- Meng H, Powers NR, Tang L, Cope NA, Zhang PX, Fuleihan R, Gibson C, Page GP, Gruen JR. A Dyslexia-Associated Variant in DCDC2 Changes Gene Expression. Behavior Genetics 2010, 41: 58-66. PMID: 21042874, PMCID: PMC3053575, DOI: 10.1007/s10519-010-9408-3.
- Bhandari V, Gruen J. The Genomics of Bronchopulmonary Dysplasia. NeoReviews 2007, 8: e336-e344. DOI: 10.1542/neo.8-8-e336.
- Bizzarro M, Hussain N, Jonsson B, Feng R, Ment L, Gruen J, Zhang H, Bhandari V. Genetic susceptibility to retinopathy of prematurity. American Journal Of Ophthalmology 2007, 143: 375-376. DOI: 10.1016/j.ajo.2006.12.016.
- Gruen J. Genetic Polymorphisms of Hemostasis Genes and Primary Outcome of Very Low Birth Weight Infants Härtel C, König I, Köster S, et al (Univ at Lübeck, Germany; Kinderklinik auf der Bult, Hannover, Germany; Olgahospital, Stuttgart, Germany; et al) Pediatrics 118:683–689, 2006§. Yearbook Of Neonatal And Perinatal Medicine 2007, 2007: 63-65. DOI: 10.1016/s8756-5005(08)70041-6.
- Zhang H, Liu L, Wang X, Gruen JR. Guideline for data analysis of genomewide association studies. Cancer Genomics & Proteomics 2007, 4: 27-34. PMID: 17726238.
- Meng H, Gruen JR. Genetic approaches to complications of prematurity. Frontiers In Bioscience-Landmark 2007, 12: 2344-51. PMID: 17127244, DOI: 10.2741/2236.
- Shetty A, Gruen J, Bhandari V. Is There a Genetic Susceptibility to Bronchopulmonary Dysplasia? Current Respiratory Medicine Reviews 2006, 2: 253-262. DOI: 10.2174/157339806778018935.
- Meng H, Smith SD, Hager K, Held M, Liu J, Olson RK, Pennington BF, DeFries JC, Gelernter J, O'Reilly-Pol T, Somlo S, Skudlarski P, Shaywitz SE, Shaywitz BA, Marchione K, Wang Y, Paramasivam M, LoTurco JJ, Page GP, Gruen JR. DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 17053-17058. PMID: 16278297, PMCID: PMC1278934, DOI: 10.1073/pnas.0508591102.
- Ahn J, Won T, Zia A, Reutter H, Kaplan D, Sparks R, Gruen J. Peaks of Linkage Are Localized by a BAC/PAC Contig of the 6p Reading Disability Locus. Genomics 2001, 78: 19-29. PMID: 11707069, DOI: 10.1006/geno.2001.6645.
- Hisama F, Gruen J, Choi J, Huseinovic M, Grigorenko E, Pauls D, Mattson R, Gelernter J, Wood F, Goei V. Human GABAB receptor 1 gene: Eight novel sequence variants. Human Mutation 2001, 17: 349-350. PMID: 11295833, DOI: 10.1002/humu.34.
- Barr C, Feng Y, Wigg K, Roberts W, Malone M, Schachar R, Tannock R, Gruen J, Goei V, Kennedy J. Identification of polymorphisms in theGABAB receptor gene and linkage study of attention-deficit hyperactivity disorder. International Journal Of Genomics 2000, 1: 1-8. DOI: 10.1002/(sici)1438-826x(200012)1:5/6<1::aid-gnfd4>3.0.co;2-8.
- Barr C, Feng Y, Wigg K, Roberts W, Malone M, Schachar R, Tannock R, Gruen J, Goei V, Kennedy J. Identification of polymorphisms in the GABAB receptor gene and linkage study of attention‐deficit hyperactivity disorder. International Journal Of Genomics 2000, 1: 194-201. DOI: 10.1002/1438-826x(200012)1:5/6<194::aid-gnfd194>3.0.co;2-2.
- Raha-Chowdhury R, Gruen J. Localization, allelic heterogeneity, and origins of the hemochromatosis gene. 2000, 75-90. DOI: 10.1017/cbo9780511666476.008.
- Bowlus C, Ahn J, Chu T, Gruen J. Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus. Cellular Immunology 1999, 196: 80-86. PMID: 10527559, DOI: 10.1006/cimm.1999.1543.
- Ahn J, Gruen J. The genomic organization of the histone clusters on human 6p21.3. Mammalian Genome 1999, 10: 768-770. PMID: 10384058, DOI: 10.1007/s003359901089.
- Goei V, Choi J, Ahn J, Bowlus C, Raha-Chowdhury R, Gruen J. Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization. Biological Psychiatry 1998, 44: 659-666. PMID: 9798068, DOI: 10.1016/s0006-3223(98)00244-3.
- Gruen J, Weissman S. Evolving Views of the Major Histocompatibility Complex. Blood 1997, 90: 4252-4265. PMID: 9373235, DOI: 10.1182/blood.v90.11.4252.
- Gruen J, Weissman S. Evolving Views of the Major Histocompatibility Complex. Blood 1997, 90: 4252-4265. DOI: 10.1182/blood.v90.11.4252.4252_4252_4265.
- Ajioka R, Jorde L, Gruen J, Yu P, Dimitrova D, Barrow J, Radisky E, Edwards C, Griffen L, Kushner J. Haplotype Analysis of Hemochromatosis: Evaluation of Different Linkage-Disequilibrium Approaches and Evolution of Disease Chromosomes. American Journal Of Human Genetics 1997, 60: 1439-1447. PMID: 9199565, PMCID: PMC1716127, DOI: 10.1086/515466.
- Weissman S, Nalabolu S, Chu T, Bowles C, Fan W, Goei V, Wei H, Sivakamasundari R, Liu Y, Xu H, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Nallur G, Gruen J. O338 A transcription map of the Major Histocompatibility Complex (MHC) Class I region. Human Immunology 1996, 47: 64. DOI: 10.1016/0198-8859(96)85033-6.
- Chu T, Capossela A, Coleman R, Goei V, Nallur G, Gruen J. Cloning of a New "Finger" Protein Gene (ZNF173) within the Class I Region of the Human MHC. Genomics 1995, 29: 229-239. PMID: 8530076, DOI: 10.1006/geno.1995.1236.
- Gruen J, Goei V, Summers K, Capossela A, Powell L, Halliday J, Zoghbi H, Shukla H, Weissman S. Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE). Genomics 1992, 14: 232-240. PMID: 1427838, DOI: 10.1016/s0888-7543(05)80211-3.
- Swaroop A, Agarwal N, Gruen J, Bick D, Weissman S. Differential expression of novel Gsα signal transduction protein cDNA species. Nucleic Acids Research 1991, 19: 4725-4729. PMID: 1716359, PMCID: PMC328715, DOI: 10.1093/nar/19.17.4725.
- Yale NeonatologyYale New Haven Children's Hospital1 Park Street, Ste West Pavilion - 2nd FloorNew Haven, CT 06504
- Yale NeonatologyYale New Haven Children's Hospital1 Park Street, Ste West Pavilion - 2nd FloorNew Haven, CT 06504