Janna D Helfrich, MD
she/her/hers
Anesthesiology
Titles
- Assistant Professor
Education & Training
- ResidentUniversity Medical Center Tuebingen (2022)
- Postdoctoral FellowUniversity of California at Berkeley (2019)
- ResidentUniversity Medical Center Hamburg-Eppendorf (2016)
- Fellow, Intensive Care MedicineUniversity Medical Center Hamburg Eppendorf (2016)
- Fellow, Prehospital Emergency CareUniversity Medical Center Hamburg-Eppendorf (2015)
- PhDCharite University Medical Center, Physiology (2015)
- MDCharite University Medical Center Berlin, Medicine (2012)
Languages Spoken
- English
- Deutsch (German)
Additional Information
Honors & Recognitions
- WAKWin Mentorship Award: German Association for Anesthesiology and Intensive Care Medicine (DGAI) (2021)
- Travel Grant: German Academic Scholarship Foundation (2012)
- Travel Grant: German Academic Scholarship Foundation (2012)
- Travel Grant: German Academic Scholarship Foundation (2011)
- Travel Grant: Federal Association of Medical Students in Germany (2011)
Board Certifications
- German Board Certificate, Anesthesiology (2022)
Publications
- Berger-Estilita J, Baron Shahaf D, Barreto Chang O, Bonhomme V, Crisan I, Fernández-Candil J, Garcia P, Gisselbaek M, Glezerson B, Hight D, Jakobsen K, Rimstad I, Kaiser H, Kratzer S, Koch S, Dilmen O, Kreuzer M, Helfrich J, Lersch F, Lobo F, Marty A, Marcolino I, Meco B, Palanca B, Pilge S, Radtke F, Rasulo F, Raz A, Romagnoli S, Romero C, Schneider G, Sepúlveda P, Shmukler D, Sinner B, Soehle M, Thyrso de Lara F, Vacas S, Vide S, von Dincklage F, Saxena S, Absalom A. Consensus document on electroencephalography education in anaesthesiology: defining learning outcomes: A modified four-round Delphi study. European Journal Of Anaesthesiology 2026 PMID: 41709666, DOI: 10.1097/eja.0000000000002346.
- von Dincklage F, Helfrich J, Koch S, Soehle M, Berger-Estilita J, Bublitz V, Bonhomme V, Sleigh J, Schneider G, Kreuzer M, Radtke F. Introducing the Safe Brain Initiative’s EEG boot camp for anaesthesia for standardised training on how to use the electroencephalogram for perioperative care. BMC Anesthesiology 2025, 25: 449. PMID: 40975762, PMCID: PMC12449795, DOI: 10.1186/s12871-025-03276-8.
- Hahn M, Lendner J, Anwander M, Slama K, Knight R, Lin J, Helfrich R. A tradeoff between efficiency and robustness in the hippocampal-neocortical memory network during human and rodent sleep. Progress In Neurobiology 2024, 242: 102672. PMID: 39369838, DOI: 10.1016/j.pneurobio.2024.102672.
- Lendner J, Helfrich R. Defining slow wave sleep without slow waves. Trends In Neurosciences 2024, 47: 853-855. PMID: 39327160, DOI: 10.1016/j.tins.2024.09.002.
- Lendner J, Lin J, Larsson P, Helfrich R. Multiple Intrinsic Timescales Govern Distinct Brain States in Human Sleep. Journal Of Neuroscience 2024, 44: e0171242024. PMID: 39187378, PMCID: PMC11484545, DOI: 10.1523/jneurosci.0171-24.2024.
- Höhn C, Hahn M, Lendner J, Hoedlmoser K. Spectral Slope and Lempel–Ziv Complexity as Robust Markers of Brain States during Sleep and Wakefulness. ENeuro 2024, 11: eneuro.0259-23.2024. PMID: 38471778, PMCID: PMC10978822, DOI: 10.1523/eneuro.0259-23.2024.
- Lendner J, Niethard N, Mander B, van Schalkwijk F, Schuh-Hofer S, Schmidt H, Knight R, Born J, Walker M, Lin J, Helfrich R. Human REM sleep recalibrates neural activity in support of memory formation. Science Advances 2023, 9: eadj1895. PMID: 37624898, PMCID: PMC10456851, DOI: 10.1126/sciadv.adj1895.
- Lendner J, Helfrich R. How Can I Run Sleep and Anesthesia Studies with Intracranial EEG? Studies In Neuroscience, Psychology And Behavioral Economics 2023, 315-330. DOI: 10.1007/978-3-031-20910-9_20.
- van Schalkwijk F, Weber J, Hahn M, Lendner J, Inostroza M, Lin J, Helfrich R. An evolutionary conserved division-of-labor between archicortical and neocortical ripples organizes information transfer during sleep. Progress In Neurobiology 2023, 227: 102485. PMID: 37353109, DOI: 10.1016/j.pneurobio.2023.102485.
- Lendner J, Harler U, Daume J, Engel A, Zöllner C, Schneider T, Fischer M. Oscillatory and aperiodic neuronal activity in working memory following anesthesia. Clinical Neurophysiology 2023, 150: 79-88. PMID: 37028144, DOI: 10.1016/j.clinph.2023.03.005.
- Toker D, Pappas I, Lendner J, Frohlich J, Mateos D, Muthukumaraswamy S, Carhart-Harris R, Paff M, Vespa P, Monti M, Sommer F, Knight R, D’Esposito M. Consciousness is supported by near-critical slow cortical electrodynamics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2024455119. PMID: 35145021, PMCID: PMC8851554, DOI: 10.1073/pnas.2024455119.
- Helfrich R, Lendner J, Knight R. Aperiodic sleep networks promote memory consolidation. Trends In Cognitive Sciences 2021, 25: 648-659. PMID: 34127388, PMCID: PMC9017392, DOI: 10.1016/j.tics.2021.04.009.
- Lendner J. What Is Anesthesia? Frontiers For Young Minds 2021, 9: 524571. DOI: 10.3389/frym.2021.524571.
- Lendner J, Helfrich R, Mander B, Romundstad L, Lin J, Walker M, Larsson P, Knight R. An electrophysiological marker of arousal level in humans. ELife 2020, 9: e55092. PMID: 32720644, PMCID: PMC7394547, DOI: 10.7554/elife.55092.
- Helfrich R, Lendner J, Mander B, Guillen H, Paff M, Mnatsakanyan L, Vadera S, Walker M, Lin J, Knight R. Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans. Nature Communications 2019, 10: 3572. PMID: 31395890, PMCID: PMC6687745, DOI: 10.1038/s41467-019-11444-x.
- Radtke F, Franck M, Lendner J, Krüger S, Wernecke K, Spies C. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction. British Journal Of Anaesthesia 2013, 110: i98-i105. PMID: 23539235, DOI: 10.1093/bja/aet055.
Titles
- Assistant Professor
Education & Training
- ResidentUniversity Medical Center Tuebingen (2022)
- Postdoctoral FellowUniversity of California at Berkeley (2019)
- ResidentUniversity Medical Center Hamburg-Eppendorf (2016)
- Fellow, Intensive Care MedicineUniversity Medical Center Hamburg Eppendorf (2016)
- Fellow, Prehospital Emergency CareUniversity Medical Center Hamburg-Eppendorf (2015)
- PhDCharite University Medical Center, Physiology (2015)
- MDCharite University Medical Center Berlin, Medicine (2012)
Languages Spoken
- English
- Deutsch (German)
Additional Information
Honors & Recognitions
- WAKWin Mentorship Award: German Association for Anesthesiology and Intensive Care Medicine (DGAI) (2021)
- Travel Grant: German Academic Scholarship Foundation (2012)
- Travel Grant: German Academic Scholarship Foundation (2012)
- Travel Grant: German Academic Scholarship Foundation (2011)
- Travel Grant: Federal Association of Medical Students in Germany (2011)
Board Certifications
- German Board Certificate, Anesthesiology (2022)
Publications
- Berger-Estilita J, Baron Shahaf D, Barreto Chang O, Bonhomme V, Crisan I, Fernández-Candil J, Garcia P, Gisselbaek M, Glezerson B, Hight D, Jakobsen K, Rimstad I, Kaiser H, Kratzer S, Koch S, Dilmen O, Kreuzer M, Helfrich J, Lersch F, Lobo F, Marty A, Marcolino I, Meco B, Palanca B, Pilge S, Radtke F, Rasulo F, Raz A, Romagnoli S, Romero C, Schneider G, Sepúlveda P, Shmukler D, Sinner B, Soehle M, Thyrso de Lara F, Vacas S, Vide S, von Dincklage F, Saxena S, Absalom A. Consensus document on electroencephalography education in anaesthesiology: defining learning outcomes: A modified four-round Delphi study. European Journal Of Anaesthesiology 2026 PMID: 41709666, DOI: 10.1097/eja.0000000000002346.
- von Dincklage F, Helfrich J, Koch S, Soehle M, Berger-Estilita J, Bublitz V, Bonhomme V, Sleigh J, Schneider G, Kreuzer M, Radtke F. Introducing the Safe Brain Initiative’s EEG boot camp for anaesthesia for standardised training on how to use the electroencephalogram for perioperative care. BMC Anesthesiology 2025, 25: 449. PMID: 40975762, PMCID: PMC12449795, DOI: 10.1186/s12871-025-03276-8.
- Hahn M, Lendner J, Anwander M, Slama K, Knight R, Lin J, Helfrich R. A tradeoff between efficiency and robustness in the hippocampal-neocortical memory network during human and rodent sleep. Progress In Neurobiology 2024, 242: 102672. PMID: 39369838, DOI: 10.1016/j.pneurobio.2024.102672.
- Lendner J, Helfrich R. Defining slow wave sleep without slow waves. Trends In Neurosciences 2024, 47: 853-855. PMID: 39327160, DOI: 10.1016/j.tins.2024.09.002.
- Lendner J, Lin J, Larsson P, Helfrich R. Multiple Intrinsic Timescales Govern Distinct Brain States in Human Sleep. Journal Of Neuroscience 2024, 44: e0171242024. PMID: 39187378, PMCID: PMC11484545, DOI: 10.1523/jneurosci.0171-24.2024.
- Höhn C, Hahn M, Lendner J, Hoedlmoser K. Spectral Slope and Lempel–Ziv Complexity as Robust Markers of Brain States during Sleep and Wakefulness. ENeuro 2024, 11: eneuro.0259-23.2024. PMID: 38471778, PMCID: PMC10978822, DOI: 10.1523/eneuro.0259-23.2024.
- Lendner J, Niethard N, Mander B, van Schalkwijk F, Schuh-Hofer S, Schmidt H, Knight R, Born J, Walker M, Lin J, Helfrich R. Human REM sleep recalibrates neural activity in support of memory formation. Science Advances 2023, 9: eadj1895. PMID: 37624898, PMCID: PMC10456851, DOI: 10.1126/sciadv.adj1895.
- Lendner J, Helfrich R. How Can I Run Sleep and Anesthesia Studies with Intracranial EEG? Studies In Neuroscience, Psychology And Behavioral Economics 2023, 315-330. DOI: 10.1007/978-3-031-20910-9_20.
- van Schalkwijk F, Weber J, Hahn M, Lendner J, Inostroza M, Lin J, Helfrich R. An evolutionary conserved division-of-labor between archicortical and neocortical ripples organizes information transfer during sleep. Progress In Neurobiology 2023, 227: 102485. PMID: 37353109, DOI: 10.1016/j.pneurobio.2023.102485.
- Lendner J, Harler U, Daume J, Engel A, Zöllner C, Schneider T, Fischer M. Oscillatory and aperiodic neuronal activity in working memory following anesthesia. Clinical Neurophysiology 2023, 150: 79-88. PMID: 37028144, DOI: 10.1016/j.clinph.2023.03.005.
- Toker D, Pappas I, Lendner J, Frohlich J, Mateos D, Muthukumaraswamy S, Carhart-Harris R, Paff M, Vespa P, Monti M, Sommer F, Knight R, D’Esposito M. Consciousness is supported by near-critical slow cortical electrodynamics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2024455119. PMID: 35145021, PMCID: PMC8851554, DOI: 10.1073/pnas.2024455119.
- Helfrich R, Lendner J, Knight R. Aperiodic sleep networks promote memory consolidation. Trends In Cognitive Sciences 2021, 25: 648-659. PMID: 34127388, PMCID: PMC9017392, DOI: 10.1016/j.tics.2021.04.009.
- Lendner J. What Is Anesthesia? Frontiers For Young Minds 2021, 9: 524571. DOI: 10.3389/frym.2021.524571.
- Lendner J, Helfrich R, Mander B, Romundstad L, Lin J, Walker M, Larsson P, Knight R. An electrophysiological marker of arousal level in humans. ELife 2020, 9: e55092. PMID: 32720644, PMCID: PMC7394547, DOI: 10.7554/elife.55092.
- Helfrich R, Lendner J, Mander B, Guillen H, Paff M, Mnatsakanyan L, Vadera S, Walker M, Lin J, Knight R. Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans. Nature Communications 2019, 10: 3572. PMID: 31395890, PMCID: PMC6687745, DOI: 10.1038/s41467-019-11444-x.
- Radtke F, Franck M, Lendner J, Krüger S, Wernecke K, Spies C. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction. British Journal Of Anaesthesia 2013, 110: i98-i105. PMID: 23539235, DOI: 10.1093/bja/aet055.