- Yale Medicine Fertility Center200 West Campus DriveFl 2Orange, CT 06477
Harvey Kliman, MD, PhD
Biography
Harvey J. Kliman, MD, PhD, is a physician scientist who specializes in studying and treating infertility and pregnancy complications, including recurrent pregnancy loss. He is also the director of the Reproductive and Placental Research Unit at Yale School of Medicine.
“Much of my research focuses on the field of embryo implantation and what can go wrong in the process,” says Dr. Kliman, who developed the Endometrial Function Test®, which examines the uterine lining. “If the endometrium isn’t working correctly, a woman will not get pregnant.”
To use the test, a doctor takes a small sample of a woman’s endometrium (the mucous membrane lining the uterus) at two different times during her menstrual cycle. “The test tells us if we should give the patient more or less estrogen or progesterone before we transfer an embryo into her uterus,” Kliman explains. “Or sometimes we find inflammation, which we might need to treat.”
Dr. Kliman’s other research investigates pregnancy loss and recurrent pregnancy loss (the loss of two or more consecutive pregnancies). Dr. Kliman examines tissue samples from the placenta to understand why a loss happened.
“I will meet with the family and go through why they had their loss and what they can do the next time to hopefully prevent it,” he says. “Behind every healthy baby is a healthy placenta. The placenta is like the roots of a tree. The leaves and branches are the fetus. The tree trunk is the umbilical cord. If there aren't enough nutrients, if there's an infection, or if there's something developmentally wrong with that placenta, the roots don't grow normally and that can lead to problems.”
When it comes to working with families who have experienced pregnancy loss, Dr. Kliman says his first priority is to assure them it’s not their fault. “And if we can find a reason, we try to treat it,” he says. “I love helping patients. It’s amazing to help them overcome problems with implantation or a terrible loss, and see them achieve a successful pregnancy. I can't think of anything better.”
Titles
- Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences
- Director, Reproductive and Placental Research Unit
Education & Training
- FellowUniversity of Pennsylvania School of Medicine (1987)
- ResidentHospital of the University of Pennsylvania (1985)
- MDUniversity of Chicago (1981)
- PhDUniversity of Chicago (1980)
Additional Information
- AB of Pathology, Pathology Anatomic/Clinical (1986)
- Yale University School of Medicine (2011 - 2015): Yale School of Medicine Admissions Committee
- Kliman HJ, Firestein MR, Hofmann KM, Milano KM, Holzer PH, Brink LT, Odendaal HJ, Fifer WP. Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes. Placenta 2020, 103: 172-176. PMID: 33152642, PMCID: PMC8448462, DOI: 10.1016/j.placenta.2020.10.014.
- Thompson B, Holzer P, Kliman H. Placental Pathology Findings in Unexplained Pregnancy Losses. Reproductive Sciences 2023, 31: 488-504. PMID: 37725247, PMCID: PMC10827979, DOI: 10.1007/s43032-023-01344-3.
- Grun M, Honhar P, Wang Y, Rossano S, Khang M, Suh H, Fowles K, Kliman H, Cavaliere A, Carson R, Marquez‐Nostra B, Saltzman W. Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation. Bioengineering & Translational Medicine 2024, 9 PMCID: PMC11561825, DOI: 10.1002/btm2.10661.
- Frankfurter D, Kliman H. Progress on the Endometrium. Obstetrics And Gynecology Clinics Of North America 2023, 50: 677-694. PMID: 37914487, DOI: 10.1016/j.ogc.2023.09.002.
- Olney K, Plaisier S, Phung T, Silasi M, Perley L, O’Bryan J, Ramirez L, Kliman H, Wilson M. Sex differences in early and term placenta are conserved in adult tissues. Biology Of Sex Differences 2022, 13: 74. PMID: 36550527, PMCID: PMC9773522, DOI: 10.1186/s13293-022-00470-y.
- Phung TN, Olney KC, Pinto BJ, Silasi M, Perley L, O'Bryan J, Kliman HJ, Wilson MA. X chromosome inactivation in the human placenta is patchy and distinct from adult tissues. Human Genetics And Genomics Advances 2022, 3: 100142. PMID: 36187227, PMCID: PMC9519611, DOI: 10.1016/j.xhgg.2022.100142.
- Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.
- Pinar H, Gordijn SJ, Grynspan D, Kingdom J, Roberts DJ, Kerzner L, Bates SV, Carreon CK, Leeman KT, Salafia C, Cohen M, Castro E, Ravishankar S, Kliman HJ, Dahlstrom J, Silver B, Heazell A. Pathologic Assessment of the Placenta: Evidence Compared With Tradition. Obstetrics And Gynecology 2022, 140: 341-342. PMID: 35852288, DOI: 10.1097/aog.0000000000004883.
- Phung TN, Olney KC, Pinto BJ, Silasi M, Perley L, O’Bryan J, Kliman HJ, Wilson MA. X chromosome inactivation in the human placenta is patchy and distinct from adult tissues. Human Genetics And Genomics Advances 2022, 3: 100121. PMID: 35712697, PMCID: PMC9194956, DOI: 10.1016/j.xhgg.2022.100121.
- Firestein MR, Kliman HJ, Sania A, Brink LT, Holzer PH, Hofmann KM, Milano KM, Pini N, Shuffrey LC, Odendaal HJ, Fifer WP. Trophoblast inclusions and adverse birth outcomes. PLOS ONE 2022, 17: e0264733. PMID: 35231069, PMCID: PMC8887719, DOI: 10.1371/journal.pone.0264733.
- Tal R, Kisa J, Abuwala N, Kliman HJ, Shaikh S, Chen AY, Lyu F, Taylor HS. Bone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus. Stem Cells 2021, 39: 1489-1505. PMID: 34224633, PMCID: PMC9313624, DOI: 10.1002/stem.3431.
- Feliciano D, Ott CM, Espinosa-Medina I, Weigel AV, Benedetti L, Milano KM, Tang Z, Lee T, Kliman HJ, Guller SM, Lippincott-Schwartz J. YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. Nature Communications 2021, 12: 4502. PMID: 34301937, PMCID: PMC8302681, DOI: 10.1038/s41467-021-24708-2.
- Tal A, Tal R, Kliman HJ, Taylor HS. Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration. American Journal Of Pathology 2021, 191: 1292-1302. PMID: 33964217, PMCID: PMC8261475, DOI: 10.1016/j.ajpath.2021.04.011.
- Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Team Y, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.
- Katz J, Holzer PH, Kliman HJ. Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study. Placenta 2021, 114: 133-138. PMID: 33941390, DOI: 10.1016/j.placenta.2021.04.010.
- Kliman H. Placenta. 2021, 3499-3506. DOI: 10.1007/978-3-319-91280-6_1553.
- Kliman HJ. Noyes, Hertig, and Rock revisited. F&S Reports 2020, 1: 2-4. PMID: 34223203, PMCID: PMC8244307, DOI: 10.1016/j.xfre.2020.04.004.
- Kliman H, Ling I, Milano K. Efficacy of telotristat ethyl: A peripheral tryptophan hydroxylase inhibitor that blocks serotonin biosynthesis against cultured liposarcoma, colon cancer, and cholangiocarcinoma cell lines. Journal Of Clinical Oncology 2020, 38: e15602-e15602. DOI: 10.1200/jco.2020.38.15_suppl.e15602.
- Pavlicev M, Zupan AM, Barry A, Walters S, Milano KM, Kliman HJ, Wagner GP. An experimental test of the ovulatory homolog model of female orgasm. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 20267-20273. PMID: 31570579, PMCID: PMC6789565, DOI: 10.1073/pnas.1910295116.
- Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.
- Kliman HJ, Frankfurter D. Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium. Fertility And Sterility 2019, 111: 618-628. PMID: 30929719, DOI: 10.1016/j.fertnstert.2019.02.011.
- Mackie DI, Al Mutairi F, Davis RB, Kechele DO, Nielsen NR, Snyder JC, Caron MG, Kliman HJ, Berg JS, Simms J, Poyner DR, Caron KM. hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. Journal Of Experimental Medicine 2018, 215: 2339-2353. PMID: 30115739, PMCID: PMC6122977, DOI: 10.1084/jem.20180528.
- Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 2018, 3 PMID: 29305462, PMCID: PMC6049088, DOI: 10.1126/sciimmunol.aao1680.
- Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology 2018, 159: 1609-1629. PMID: 29381782, DOI: 10.1210/en.2017-03025.
- Isakov KMM, Emerson JW, Campbell KH, Galerneau F, Anders AM, Lee YK, Subramanyam P, Roberts AE, Kliman HJ. Estimated Placental Volume and Gestational Age. American Journal Of Perinatology 2017, 35: 748-757. PMID: 29281842, DOI: 10.1055/s-0037-1615285.
- Sonek J, Krantz D, Carmichael J, Downing C, Jessup K, Haidar Z, Ho S, Hallahan T, Kliman HJ, McKenna D. First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume. American Journal Of Obstetrics And Gynecology 2017, 218: 126.e1-126.e13. PMID: 29097177, DOI: 10.1016/j.ajog.2017.10.024.
- Salvante KG, Milano K, Kliman HJ, Nepomnaschy PA. Placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy. Journal Of Developmental Origins Of Health And Disease 2017, 8: 149-154. PMID: 28112069, DOI: 10.1017/s2040174416000611.
- Stephenson MD, McQueen D, Winter M, Kliman HJ. Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss. Fertility And Sterility 2017, 107: 684-690.e2. PMID: 28081870, DOI: 10.1016/j.fertnstert.2016.11.029.
- Campbell K, Galerneau F, Kliman H, Bukowski R. 563: Estimated placental volume (EPV): a novel predictor of small for gestational age birth weight (SGA). American Journal Of Obstetrics And Gynecology 2016, 214: s303. DOI: 10.1016/j.ajog.2015.10.607.
- Kliman HJ. Comment on “The placenta harbors a unique microbiome”. Science Translational Medicine 2014, 6: 254le4-254le4. PMID: 25232175, DOI: 10.1126/scitranslmed.3009864.
- Arleo EK, Troiano RN, da Silva R, Greenbaum D, Kliman HJ. Utilizing Two-Dimensional Ultrasound to Develop Normative Curves for Estimated Placental Volume. American Journal Of Perinatology 2013, 31: 683-688. PMID: 24108663, DOI: 10.1055/s-0033-1357265.
- Kliman H, Milano K. The majority of miscarriages are caused by genetic abnormalities. Fertility And Sterility 2013, 100: s306. DOI: 10.1016/j.fertnstert.2013.07.996.
- Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. Trophoblast Inclusions Are Significantly Increased in the Placentas of Children in Families at Risk for Autism. Biological Psychiatry 2013, 74: 204-211. PMID: 23623455, PMCID: PMC3755347, DOI: 10.1016/j.biopsych.2013.03.006.
- Kliman H. Placenta. 2013, 2267-2275. DOI: 10.1007/978-1-4419-1698-3_1553.
- Laine K, Staff A, Murzakanova G, Gustafsson J, Barbero M, Ye S, Kliman H. OP17.03: Second trimester estimated placental volume (EPV) screening is predictive of SGA and LGA newborns and adverse pregnancy outcomes. Ultrasound In Obstetrics And Gynecology 2012, 40: 105-105. DOI: 10.1002/uog.11549.
- Rosner M, Gebb J, Ye S, Dar P, Kliman H. OP17.02: 2D Estimated Placental Volume (EPV) measurements in first trimester are reliable and correlate with measurements obtained by the 3D VOCAL™ technique. Ultrasound In Obstetrics And Gynecology 2012, 40: 105-105. DOI: 10.1002/uog.11548.
- Anders A, Campbell K, Galerneau F, Ye S, Kliman H. P16.10: Vscan portable ultrasound scanner accurately measures estimated placental volume (EPV). Ultrasound In Obstetrics And Gynecology 2012, 40: 232-233. DOI: 10.1002/uog.11979.
- Kliman H. Placental volume. BMC Pregnancy And Childbirth 2012, 12: a4. PMCID: PMC3428687, DOI: 10.1186/1471-2393-12-s1-a4.
- Kliman H. Structural abnormalities in the placenta. BMC Pregnancy And Childbirth 2012, 12: a3. PMCID: PMC3428688, DOI: 10.1186/1471-2393-12-s1-a3.
- Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R. Placental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia. Reproductive Sciences 2012, 19: 16-30. PMID: 21989657, DOI: 10.1177/1933719111424445.
- Kliman H, Campbell K, Anders A, Lee Y, Subramanyam P, Funai E, Galerneau F. 354: Estimated placental volume (EPV): generation of normative growth curves. American Journal Of Obstetrics And Gynecology 2012, 206: s166-s167. DOI: 10.1016/j.ajog.2011.10.372.
- Stephenson M, Willis M, Schultz P, Milano K, Kliman H. Abnormal nuclear cyclin E expression in endometrial glands of patients with recurrent pregnancy loss (RPL): response to vaginal micronized progesterone adminstration. Fertility And Sterility 2009, 92: s244-s245. DOI: 10.1016/j.fertnstert.2009.07.1612.
- Azpurua H, Funai E, Coraluzzi L, Doherty L, Sasson I, Kliman M, Kliman H. Determination of Placental Weight Using Two-dimensional Sonography and Volumetric Mathematic Modeling. American Journal Of Perinatology 2009, 27: 151-155. PMID: 19653142, DOI: 10.1055/s-0029-1234034.
- Lash GE, Ansari T, Bischof P, Burton GJ, Chamley L, Crocker I, Dantzer V, Desoye G, Drewlo S, Fazleabas A, Jansson T, Keating S, Kliman HJ, Lang I, Mayhew T, Meiri H, Miller RK, Nelson DM, Pfarrer C, Roberts C, Sammar M, Sharma S, Shiverick K, Strunk D, Turner MA, Huppertz B. IFPA Meeting 2008 Workshops Report. Placenta 2008, 30: 4-14. PMID: 19084270, PMCID: PMC2668143, DOI: 10.1016/j.placenta.2008.11.014.
- Funai E, Labowsky A, Drewes C, Kliman H. Timing of Fetal Meconium Absorption by Amnionic Macrophages. American Journal Of Perinatology 2008, 26: 093-097. PMID: 19031358, DOI: 10.1055/s-0028-1103028.
- Azpurua‐Pardi H, Funai E, Coraluzzi L, Sasson I, Doherty L, Kliman M, Kliman H. OP23.10: Determination of placental weight using two‐dimensional sonography and volumetric mathematic modeling. Ultrasound In Obstetrics And Gynecology 2008, 32: 391-392. DOI: 10.1002/uog.5877.
- Yusuf K, Kliman HJ. The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas. Journal Of Perinatal Medicine 2008, 36: 291-296. PMID: 18598117, DOI: 10.1515/jpm.2008.054.
- Johnston-MacAnanny E, Kliman H, Maier D, Nulsen J, Benadiva C. The role of endometrial function test (EFT®) in recurrent implantation failure (RIF) in IVF. Fertility And Sterility 2007, 88: s162. DOI: 10.1016/j.fertnstert.2007.07.563.
- Hecht JL, Kliman HJ, Allred EN, Pflueger SM, Chang C, Doss BJ, Roberts D, Livasy CA, Bhan I, Zambrano E, Ross DW, Senagore P, Husain AN, Leviton A. Reference Weights for Placentas Delivered before the 28th Week of Gestation. Placenta 2007, 28: 987-990. PMID: 17573110, DOI: 10.1016/j.placenta.2007.04.009.
- Lee L, Heitor F, Kliman H, Mcelrath T, Majzoub J. Syncytiotrophoblasts of preeclamptic placentas overexpress corticotropin-releasing hormone mRNA. American Journal Of Obstetrics And Gynecology 2006, 195: s18. DOI: 10.1016/j.ajog.2006.10.048.
- Kliman HJ, Honig S, Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients. Journal Of Assisted Reproduction And Genetics 2006, 23: 299-303. PMID: 16983518, DOI: 10.1007/s10815-006-9061-1.
- Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ. Placental Trophoblast Inclusions in Autism Spectrum Disorder. Biological Psychiatry 2006, 61: 487-491. PMID: 16806106, DOI: 10.1016/j.biopsych.2006.03.068.
- Hecht J, Onderdonk A, Delaney M, Allred E, Kliman H, Zambrano E, Solveig P, Livasy C, Bhan I, Leviton A. Characterization of chorioamnionitis in second trimester c-section placentas and correlation with microorganism recovery from sub-amniotic tissues. Pediatric And Developmental Pathology 2006, preprint: 1. DOI: 10.2350/07-06-0285.
- Catalanotti JS, Spandorfer SD, Barmat LI, Rosenwaks Z, McSweet JC, Kliman HJ. Mouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization–embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures. Fertility And Sterility 2006, 85: 255-258. PMID: 16412771, DOI: 10.1016/j.fertnstert.2005.06.060.
- Kliman H, Copperman A, Honig S, Walls D, McSweet J. Optimization of Endometrial Preparation Results in a Normal Endometrial Function Test® (EFT®) and Good Reproductive Outcome in Donor Ovum Recipients. Fertility And Sterility 2005, 84: s271-s272. DOI: 10.1016/j.fertnstert.2005.07.705.
- Willman S, Kliman H. Comparison of the Luteal Phase after Pituitary Suppression With GnRH-Agonist Versus GnRH Antagonist in Controlled Ovarian Hyperstimulation. Fertility And Sterility 2005, 84: s308. DOI: 10.1016/j.fertnstert.2005.07.806.
- Rackow B, Kliman H, Taylor H. GnRH Antagonists Do Not Affect Peri-Implantation Endometrial HOXA10 Expression. Fertility And Sterility 2005, 84: s309-s310. DOI: 10.1016/j.fertnstert.2005.07.809.
- Stephenson M, Houlihan E, Karrison T, Franco A, McSweet J, Kliman H. Successful treatment of endometrial-associated recurrent pregnancy loss (RPL): A blinded, controlled study. Fertility And Sterility 2004, 82: s79. DOI: 10.1016/j.fertnstert.2004.07.201.
- Lorch A, Franco A, McSweet J, Keefe D, Kliman H. Telomerase expression in fertile patients compared to infertile patients with thin endometria. Fertility And Sterility 2004, 82: s74. DOI: 10.1016/j.fertnstert.2004.07.189.
- Kliman HJ, Segel L. The placenta may predict the baby. Journal Of Theoretical Biology 2003, 225: 143-145. PMID: 14559066, DOI: 10.1016/s0022-5193(03)00248-0.
- Kliman H, McSweet J, Franco A, Ying X, Zhao Y, Stetten G. Trophoblast inclusions are rare in elective terminations and normal deliveries, but common in cases with karyotypic abnormalities. Fertility And Sterility 2003, 80: 88. DOI: 10.1016/s0015-0282(03)02035-1.
- Dubowy RL, Feinberg RF, Keefe DL, Doncel GF, Williams SC, McSweet JC, Kliman HJ. Improved endometrial assessment using cyclin E and p27. Fertility And Sterility 2003, 80: 146-156. PMID: 12849817, DOI: 10.1016/s0015-0282(03)00573-9.
- Kliman H. Trophoblast Toxicity Assay (TTA). 2003 DOI: 10.1201/9780203008799.ch44.
- Kliman H, McSweet J, Grunert G, Cardone V, Cadesky K, Keefe D. The endometrial function test (EFT) directs care and predicts ART outcome. Fertility And Sterility 2002, 78: s17. DOI: 10.1016/s0015-0282(02)03424-6.
- Meaddough EL, Olive DL, Gallup P, Perlin M, Kliman HJ. Sexual Activity, Orgasm and Tampon Use Are Associated with a Decreased Risk for Endometriosis. Gynecologic And Obstetric Investigation 2002, 53: 163-169. PMID: 12053101, DOI: 10.1159/000058368.
- Kliman H, McSweet J, Grunert G, Cardone V. Efficacy of the Endometrial Function Test in Assisted Reproductive Technology Practice. Obstetrics And Gynecology 2002, 99: 46s. DOI: 10.1097/00006250-200204001-00101.
- Kliman H, Olive D. Authors’ response to the Letters to the Editors concerning the article by Meaddough et al: Sexual Activity, Orgasm and Tampon Use Are Associated with a Decreased Risk for Endometriosis. Gynecologic And Obstetric Investigation 2002, 54: 65-66. DOI: 10.1159/000068357.
- Bagot C, Kliman H, Taylor H. Maternal Hoxa10 is required for pinopod formation in the development of mouse uterine receptivity to embryo implantation. Developmental Dynamics 2001, 222: 538-544. PMID: 11747087, DOI: 10.1002/dvdy.1209.
- Schwartz LB, Naftolin F, Lyttle CR, Penzias AS, Meaddough EL, Kliman HJ. Mouse ascites golgi (MAG) mucin expression and regulation by progesterone in the rat uterus. Reproductive Sciences 2001, 8: 216-23. PMID: 11525897, DOI: 10.1016/s1071-5576(01)00115-0.
- Schwartz L, Naftolin F, Lyttle C, Penzias A, Meaddough E, Kliman H. Mouse Ascites Golgi (MAG) Mucin Expression and Regulation by Progesterone in the Rat Uterus. Reproductive Sciences 2001, 8: 216-223. DOI: 10.1177/107155760100800406.
- Kliman H. Uteroplacental Blood Flow The Story of Decidualization, Menstruation, and Trophoblast Invasion. American Journal Of Pathology 2000, 157: 1759-1768. PMID: 11106547, PMCID: PMC1885765, DOI: 10.1016/s0002-9440(10)64813-4.
- Dubowy R, Feinberg R, Kliman H. Endometrial Biopsy and Infertility Evaluation: New Insights from Cyclins. Fertility And Sterility 2000, 74: s183-s184. DOI: 10.1016/s0015-0282(00)01255-3.
- Acosta A, Elberger L, Borghi M, Calamera J, Chemes H, Doncel G, Kliman H, Lema B, Lustig L, Papier S. Endometrial dating and determination of the window of implantation in healthy fertile women. Fertility And Sterility 2000, 73: 788-798. PMID: 10731542, DOI: 10.1016/s0015-0282(99)00605-6.
- Kliman H, Barmat L, Wang F. P-134 MAG mucin expression abnormalities in natural cycle biopsies predict subsequent IVF failure. Fertility And Sterility 1997, 68: s156. DOI: 10.1016/s0015-0282(97)90949-3.
- P-060 Estrogen treatment converts MAG-negative (unreceptive) endometrium to MAG-positive (receptive)Kliman H, VanDeerlin P, Feinberg R. P-060 Estrogen treatment converts MAG-negative (unreceptive) endometrium to MAG-positive (receptive). Fertility And Sterility 1997, 68: s120-s121. DOI: 10.1016/s0015-0282(97)90876-1.
- Kliman H, Feinberg R, VanDeerlin P, Barmat L, Moomjy M, Keefe D, Wang F, Olive D. P-009 Glandular developmental arrest (GDA): A unifying model of reproductive endometrial pathology. Fertility And Sterility 1997, 68: s96-s97. DOI: 10.1016/s0015-0282(97)90826-8.
- Keltz M, Attar E, Buradagunta S, Olive D, Kliman H, Arici A. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube. American Journal Of Obstetrics And Gynecology 1996, 175: 1611-1619. PMID: 8987949, DOI: 10.1016/s0002-9378(96)70114-x.
- Nachtigall MJ, Kliman HJ, Feinberg RF, Olive DL, Engin O, Arici A. The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 801-806. PMID: 8636307, DOI: 10.1210/jcem.81.2.8636307.
- Arici A, Tazuke SI, Attar E, Kliman HJ, Olive DL. Endocrinology and paracrinology. Molecular Human Reproduction 1996, 2: 40-45. PMID: 9238656, DOI: 10.1093/molehr/2.1.40.
- Kliman H, Perrotta P, Jones D. The efficacy of the placental biopsy. American Journal Of Obstetrics And Gynecology 1995, 173: 1084-1088. PMID: 7485298, DOI: 10.1016/0002-9378(95)91331-9.
- Keltz M, Kliman H, Arici A, Olive D. Endosalpingiosis found at laparoscopy for chronic pelvic pain**Presented at the 50th Annual Meeting of The American Fertility Society Meeting, San Antonio, Texas, November 5 to 10, 1994. Fertility And Sterility 1995, 64: 482-485. PMID: 7641898, DOI: 10.1016/s0015-0282(16)57780-2.
- Feinberg R, Kliman H, Bedian V, Monzon-Bordonaba F, Menzin A, Wang C. Monoclonal antibody X18A4 identifies on oncofetal fibronectin epitope distinct from the FDC-6 binding site. American Journal Of Obstetrics And Gynecology 1995, 172: 1526-1536. PMID: 7538728, DOI: 10.1016/0002-9378(95)90491-3.
- Bahado-Singh RO, Kliman H, Feng TY, Hobbins J, Copel JA, Mahoney MJ. First-trimester endocervical irrigation: feasibility of obtaining trophoblast cells for prenatal diagnosis. Obstetrics And Gynecology 1995, 85: 461-4. PMID: 7862393, DOI: 10.1016/0029-7844(94)00416-b.
- Kliman HJ, Feinberg RF, Schwartz LB, Feinman MA, Lavi E, Meaddough EL. A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium. American Journal Of Pathology 1995, 146: 166-81. PMID: 7531946, PMCID: PMC1870765.
- Rotmensch S, Liberati M, Luo J, Kliman H, Gollin Y, Bellati U, Hobbins J, Copel J. Color Doppler flow patterns and flow velocity waveforms of the intraplacental fetal circulation in growth-retarded fetuses. American Journal Of Obstetrics And Gynecology 1994, 171: 1257-1264. PMID: 7977530, DOI: 10.1016/0002-9378(94)90143-0.
- Kliman H. Trophoblast infiltration. Reproductive Medicine Review 1994, 3: 137-157. DOI: 10.1017/s0962279900000831.
- Feinberg RF, Kliman HJ, Wang CL. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 1241-1248. PMID: 8175984, DOI: 10.1210/jcem.78.5.8175984.
- Kliman HJ. The placenta revealed. American Journal Of Pathology 1993, 143: 332-6. PMID: 8342590, PMCID: PMC1887036.
- Feinberg R, Kliman H, Wang C. Transforming growth factor beta (TGFβ) stimulates tropho-uteronectin (TUN) synthesis and trophoblast adhesiveness in vitro. Placenta 1993, 14: a21. DOI: 10.1016/s0143-4004(05)80507-7.
- Kliman H, Arici A, Cunningham M, Meaddough E. Chorioamnionitis: A role for interleukin-8? Placenta 1993, 14: a37. DOI: 10.1016/s0143-4004(05)80540-5.
- Feinberg R, Kliman H. Tropho-uteronectin (tun): A unique oncofetal fibronectin deposited in the extracellular matrix of the tropho-uterine junction and regulated in vitro by cultured human trophoblast cells. Placenta 1993, 14: 167-179. DOI: 10.1016/s0143-4004(05)80292-9.
- Schwartz L, Meaddough E, Lyttle C, Penzias A, Naftolin F, Kliman H. Rat mouse ascites golgi (MAG) factor: A potential, animal model for studying endometrial receptivity to implantation. Placenta 1992, 13: a57. DOI: 10.1016/0143-4004(92)90175-s.
- Kliman H, Feinberg R, Meaddough E, Schwartz L. Mouse ascites Golgi (MAG) factor: A mucin which may be a potential menstrual cycle dependent marker of endometrial receptivity to human implantation. Placenta 1992, 13: a35. DOI: 10.1016/0143-4004(92)90131-c.
- Feinberg RF, Kliman HJ. Fetal Fibronectin and Preterm Labor. New England Journal Of Medicine 1992, 326: 708-709. PMID: 1736115, DOI: 10.1056/nejm199203053261013.
- Kliman H, Feinberg R. Differentiation of the Trophoblast. 1992, 3-25. DOI: 10.1007/978-3-642-84385-3_1.
- Feinberg RF, Kliman HJ, Cohen AW. Preeclampsia, trisomy 13, and the placental bed. Obstetrics And Gynecology 1991, 78: 505-8. PMID: 1870809.
- Lavi E, Montone K, Rorke L, Kliman H. Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage. Neurology 1991, 41: 1467-8. PMID: 1891100, DOI: 10.1212/wnl.41.9.1467.
- COUTIFARIS C, BABALOLA GO, ABISOGUN AO, KAO L, CHIN U, VADILLO‐ORTEGA F, OSHEROFF J, KLIMAN HJ, STRAUSS JF. In Vitro Systems for the Study of Human Trophoblast Implantation. Annals Of The New York Academy Of Sciences 1991, 622: 191-201. PMID: 2064180, DOI: 10.1111/j.1749-6632.1991.tb37862.x.
- Feinberg RF, Kliman HJ, Lockwood CJ. Is oncofetal fibronectin a trophoblast glue for human implantation? American Journal Of Pathology 1991, 138: 537-43. PMID: 2000933, PMCID: PMC1886265.
- Kliman H, Feinberg R, Haimowitz J. Human trophoblast-endometrial interactions in an in vitro suspension culture system. Placenta 1990, 11: 349-367. PMID: 2235916, DOI: 10.1016/s0143-4004(05)80226-7.
- Kliman HJ, Feinberg RF. Human trophoblast-extracellular matrix (ECM) interactions in vitro: ECM thickness modulates morphology and proteolytic activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 3057-3061. PMID: 2326266, PMCID: PMC53833, DOI: 10.1073/pnas.87.8.3057.
- Coutifaris C, Babalola G, Feinberg R, Kao L, Kliman H, Strauss J. Purified Human Cytotrophoblasts: Surrogates for The Blastocyst in In Vitro Models of Implantation? 1990, 687-695. DOI: 10.1007/978-1-4613-0645-0_74.
- Babalola G, Coutifaris C, Soto E, Kliman H, Shuman H, Strauss J. Aggregation of dispersed human cytotrophoblastic cells: Lessons relevant to the morphogenesis of the placenta. Developmental Biology 1990, 137: 100-108. PMID: 2295358, DOI: 10.1016/0012-1606(90)90011-7.
- Kliman H, Feinberg R, Strauss J, Haimowitz J. Interactions between human term trophoblasts and endometrium in vitro. Placenta 1989, 10: 453-454. DOI: 10.1016/0143-4004(89)90057-x.
- Feinberg R, Haimowitz J, Kliman H. Human trophoblast interaction with the extracellular matrix: A histologic assay system for studying trophoblast invasion. Placenta 1989, 10: 454-455. DOI: 10.1016/0143-4004(89)90058-1.
- Feinberg RF, Kao LC, Haimowitz JE, Queenan JT, Wun TC, Strauss JF, Kliman HJ. Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Laboratory Investigation 1989, 61: 20-6. PMID: 2473276.
- Nulsen JC, Silavin SL, Kao LC, Ringler GE, Kliman HJ, Strauss JF. Control of the steroidogenic machinery of the human trophoblast by cyclic AMP. Society Of Reproduction And Fertility 1989, 37: 147-53. PMID: 2553955.
- Kliman HJ, Coutifaris C, Babalola GO, Soto EA, Kao LC, Queenan JT, Feinberg RF, Strauss JF. The human trophoblast: homotypic and heterotypic cell-cell interactions. Progress In Clinical And Biological Research 1989, 294: 425-34. PMID: 2726976.
- Feinman M, Kliman H, Main E. HLA antigen expression and induction by gamma‐interferon in cultured human trophoblast. International Journal Of Gynecology & Obstetrics 1988, 27: 481-481. DOI: 10.1016/0020-7292(88)90155-5.
- Kao L, Caltabiano S, Wu S, Strauss J, Kliman H. The human villous cytotrophoblast: Interactions with extracellular matrix proteins, endocrine function, and cytoplasmic differentiation in the absence of syncytium formation. Developmental Biology 1988, 130: 693-702. PMID: 2848742, DOI: 10.1016/0012-1606(88)90361-2.
- ROY‐CHOUDHURY S, SEN‐MAJUMDAR A, MURTHY U, MISHRA V, KLIMAN H, NESTLER J, STRAUSS J, Manjusri D. Biosynthesis and turnover of a 34‐kDa protein growth factor in human cytotrophoblasts. The FEBS Journal 1988, 172: 777-783. PMID: 3350024, DOI: 10.1111/j.1432-1033.1988.tb13957.x.
- Feinman M, Kliman H, Main E. HLA antigen expression and induction by γ-interferon in cultured human trophoblasts. American Journal Of Obstetrics And Gynecology 1987, 157: 1429-1434. PMID: 3122576, DOI: 10.1016/s0002-9378(87)80238-7.
- ULLOA-AGUIRRE A, AUGUST A, GOLOS T, KAO L, SAKURAGI N, KLIMAN H, STRAUSS J. 8-Bromo-Adenosine 3′,5′Monophosphate Regulates Expression of Chorionic Gonadotropin and Fibronectin in Human Cytotrophoblasts*. The Journal Of Clinical Endocrinology & Metabolism 1987, 64: 1002-1009. PMID: 2435752, DOI: 10.1210/jcem-64-5-1002.
- Kliman H, Feinman M, Strauss J. Differentiaton of Human Cytotrophoblast into Syncytiotrophoblast in Culture. Trophoblast Research 1987, 407-421. DOI: 10.1007/978-1-4757-1936-9_29.
- FEINMAN M, KLIMAN H, CALTABIANO S, STRAUSS J. 8-Bromo-3′5′ -Adenosine Monophosphate Stimulates the Endocrine Activity of Human Cytotrophoblasts in Culture*. The Journal Of Clinical Endocrinology & Metabolism 1986, 63: 1211-1217. PMID: 3531221, DOI: 10.1210/jcem-63-5-1211.
- Soto E, Kliman H, Strauss J, Paavola L. Gonadotropins and Cyclic Adenosine 3′,5′-Monophosphate (cAMP) Alter the Morphology of Cultured Human Granulosa Cells. Biology Of Reproduction 1986, 34: 559-569. PMID: 3008869, DOI: 10.1095/biolreprod34.3.559.
- KLIMAN H, NESTLER J, SERMASI E, SANGER J, STRAUSS J. Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*. Endocrinology 1986, 118: 1567-1582. PMID: 3512258, DOI: 10.1210/endo-118-4-1567.
- Ballas S, Kliman H, Smith E. Glyceraldehyde-3-phosphate dehydrogenase of rat erythrocytes has no membrane component. Biochimica Et Biophysica Acta 1985, 831: 142-149. PMID: 4041465, DOI: 10.1016/0167-4838(85)90161-x.
- Kliman HJ, Steck TL. Association of glyceraldehyde-3-phosphate dehydrogenase with the human red cell membrane. A kinetic analysis. Journal Of Biological Chemistry 1980, 255: 6314-6321. PMID: 7391020, DOI: 10.1016/s0021-9258(18)43739-8.
- Yale Medicine Fertility Center200 West Campus DriveFl 2Orange, CT 06477
Biography
Harvey J. Kliman, MD, PhD, is a physician scientist who specializes in studying and treating infertility and pregnancy complications, including recurrent pregnancy loss. He is also the director of the Reproductive and Placental Research Unit at Yale School of Medicine.
“Much of my research focuses on the field of embryo implantation and what can go wrong in the process,” says Dr. Kliman, who developed the Endometrial Function Test®, which examines the uterine lining. “If the endometrium isn’t working correctly, a woman will not get pregnant.”
To use the test, a doctor takes a small sample of a woman’s endometrium (the mucous membrane lining the uterus) at two different times during her menstrual cycle. “The test tells us if we should give the patient more or less estrogen or progesterone before we transfer an embryo into her uterus,” Kliman explains. “Or sometimes we find inflammation, which we might need to treat.”
Dr. Kliman’s other research investigates pregnancy loss and recurrent pregnancy loss (the loss of two or more consecutive pregnancies). Dr. Kliman examines tissue samples from the placenta to understand why a loss happened.
“I will meet with the family and go through why they had their loss and what they can do the next time to hopefully prevent it,” he says. “Behind every healthy baby is a healthy placenta. The placenta is like the roots of a tree. The leaves and branches are the fetus. The tree trunk is the umbilical cord. If there aren't enough nutrients, if there's an infection, or if there's something developmentally wrong with that placenta, the roots don't grow normally and that can lead to problems.”
When it comes to working with families who have experienced pregnancy loss, Dr. Kliman says his first priority is to assure them it’s not their fault. “And if we can find a reason, we try to treat it,” he says. “I love helping patients. It’s amazing to help them overcome problems with implantation or a terrible loss, and see them achieve a successful pregnancy. I can't think of anything better.”
Titles
- Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences
- Director, Reproductive and Placental Research Unit
Education & Training
- FellowUniversity of Pennsylvania School of Medicine (1987)
- ResidentHospital of the University of Pennsylvania (1985)
- MDUniversity of Chicago (1981)
- PhDUniversity of Chicago (1980)
Additional Information
- AB of Pathology, Pathology Anatomic/Clinical (1986)
- Yale University School of Medicine (2011 - 2015): Yale School of Medicine Admissions Committee
- Kliman HJ, Firestein MR, Hofmann KM, Milano KM, Holzer PH, Brink LT, Odendaal HJ, Fifer WP. Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes. Placenta 2020, 103: 172-176. PMID: 33152642, PMCID: PMC8448462, DOI: 10.1016/j.placenta.2020.10.014.
- Thompson B, Holzer P, Kliman H. Placental Pathology Findings in Unexplained Pregnancy Losses. Reproductive Sciences 2023, 31: 488-504. PMID: 37725247, PMCID: PMC10827979, DOI: 10.1007/s43032-023-01344-3.
- Grun M, Honhar P, Wang Y, Rossano S, Khang M, Suh H, Fowles K, Kliman H, Cavaliere A, Carson R, Marquez‐Nostra B, Saltzman W. Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation. Bioengineering & Translational Medicine 2024, 9 PMCID: PMC11561825, DOI: 10.1002/btm2.10661.
- Frankfurter D, Kliman H. Progress on the Endometrium. Obstetrics And Gynecology Clinics Of North America 2023, 50: 677-694. PMID: 37914487, DOI: 10.1016/j.ogc.2023.09.002.
- Olney K, Plaisier S, Phung T, Silasi M, Perley L, O’Bryan J, Ramirez L, Kliman H, Wilson M. Sex differences in early and term placenta are conserved in adult tissues. Biology Of Sex Differences 2022, 13: 74. PMID: 36550527, PMCID: PMC9773522, DOI: 10.1186/s13293-022-00470-y.
- Phung TN, Olney KC, Pinto BJ, Silasi M, Perley L, O'Bryan J, Kliman HJ, Wilson MA. X chromosome inactivation in the human placenta is patchy and distinct from adult tissues. Human Genetics And Genomics Advances 2022, 3: 100142. PMID: 36187227, PMCID: PMC9519611, DOI: 10.1016/j.xhgg.2022.100142.
- Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.
- Pinar H, Gordijn SJ, Grynspan D, Kingdom J, Roberts DJ, Kerzner L, Bates SV, Carreon CK, Leeman KT, Salafia C, Cohen M, Castro E, Ravishankar S, Kliman HJ, Dahlstrom J, Silver B, Heazell A. Pathologic Assessment of the Placenta: Evidence Compared With Tradition. Obstetrics And Gynecology 2022, 140: 341-342. PMID: 35852288, DOI: 10.1097/aog.0000000000004883.
- Phung TN, Olney KC, Pinto BJ, Silasi M, Perley L, O’Bryan J, Kliman HJ, Wilson MA. X chromosome inactivation in the human placenta is patchy and distinct from adult tissues. Human Genetics And Genomics Advances 2022, 3: 100121. PMID: 35712697, PMCID: PMC9194956, DOI: 10.1016/j.xhgg.2022.100121.
- Firestein MR, Kliman HJ, Sania A, Brink LT, Holzer PH, Hofmann KM, Milano KM, Pini N, Shuffrey LC, Odendaal HJ, Fifer WP. Trophoblast inclusions and adverse birth outcomes. PLOS ONE 2022, 17: e0264733. PMID: 35231069, PMCID: PMC8887719, DOI: 10.1371/journal.pone.0264733.
- Tal R, Kisa J, Abuwala N, Kliman HJ, Shaikh S, Chen AY, Lyu F, Taylor HS. Bone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus. Stem Cells 2021, 39: 1489-1505. PMID: 34224633, PMCID: PMC9313624, DOI: 10.1002/stem.3431.
- Feliciano D, Ott CM, Espinosa-Medina I, Weigel AV, Benedetti L, Milano KM, Tang Z, Lee T, Kliman HJ, Guller SM, Lippincott-Schwartz J. YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. Nature Communications 2021, 12: 4502. PMID: 34301937, PMCID: PMC8302681, DOI: 10.1038/s41467-021-24708-2.
- Tal A, Tal R, Kliman HJ, Taylor HS. Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration. American Journal Of Pathology 2021, 191: 1292-1302. PMID: 33964217, PMCID: PMC8261475, DOI: 10.1016/j.ajpath.2021.04.011.
- Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Team Y, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.
- Katz J, Holzer PH, Kliman HJ. Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study. Placenta 2021, 114: 133-138. PMID: 33941390, DOI: 10.1016/j.placenta.2021.04.010.
- Kliman H. Placenta. 2021, 3499-3506. DOI: 10.1007/978-3-319-91280-6_1553.
- Kliman HJ. Noyes, Hertig, and Rock revisited. F&S Reports 2020, 1: 2-4. PMID: 34223203, PMCID: PMC8244307, DOI: 10.1016/j.xfre.2020.04.004.
- Kliman H, Ling I, Milano K. Efficacy of telotristat ethyl: A peripheral tryptophan hydroxylase inhibitor that blocks serotonin biosynthesis against cultured liposarcoma, colon cancer, and cholangiocarcinoma cell lines. Journal Of Clinical Oncology 2020, 38: e15602-e15602. DOI: 10.1200/jco.2020.38.15_suppl.e15602.
- Pavlicev M, Zupan AM, Barry A, Walters S, Milano KM, Kliman HJ, Wagner GP. An experimental test of the ovulatory homolog model of female orgasm. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 20267-20273. PMID: 31570579, PMCID: PMC6789565, DOI: 10.1073/pnas.1910295116.
- Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.
- Kliman HJ, Frankfurter D. Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium. Fertility And Sterility 2019, 111: 618-628. PMID: 30929719, DOI: 10.1016/j.fertnstert.2019.02.011.
- Mackie DI, Al Mutairi F, Davis RB, Kechele DO, Nielsen NR, Snyder JC, Caron MG, Kliman HJ, Berg JS, Simms J, Poyner DR, Caron KM. hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. Journal Of Experimental Medicine 2018, 215: 2339-2353. PMID: 30115739, PMCID: PMC6122977, DOI: 10.1084/jem.20180528.
- Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 2018, 3 PMID: 29305462, PMCID: PMC6049088, DOI: 10.1126/sciimmunol.aao1680.
- Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology 2018, 159: 1609-1629. PMID: 29381782, DOI: 10.1210/en.2017-03025.
- Isakov KMM, Emerson JW, Campbell KH, Galerneau F, Anders AM, Lee YK, Subramanyam P, Roberts AE, Kliman HJ. Estimated Placental Volume and Gestational Age. American Journal Of Perinatology 2017, 35: 748-757. PMID: 29281842, DOI: 10.1055/s-0037-1615285.
- Sonek J, Krantz D, Carmichael J, Downing C, Jessup K, Haidar Z, Ho S, Hallahan T, Kliman HJ, McKenna D. First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume. American Journal Of Obstetrics And Gynecology 2017, 218: 126.e1-126.e13. PMID: 29097177, DOI: 10.1016/j.ajog.2017.10.024.
- Salvante KG, Milano K, Kliman HJ, Nepomnaschy PA. Placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy. Journal Of Developmental Origins Of Health And Disease 2017, 8: 149-154. PMID: 28112069, DOI: 10.1017/s2040174416000611.
- Stephenson MD, McQueen D, Winter M, Kliman HJ. Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss. Fertility And Sterility 2017, 107: 684-690.e2. PMID: 28081870, DOI: 10.1016/j.fertnstert.2016.11.029.
- Campbell K, Galerneau F, Kliman H, Bukowski R. 563: Estimated placental volume (EPV): a novel predictor of small for gestational age birth weight (SGA). American Journal Of Obstetrics And Gynecology 2016, 214: s303. DOI: 10.1016/j.ajog.2015.10.607.
- Kliman HJ. Comment on “The placenta harbors a unique microbiome”. Science Translational Medicine 2014, 6: 254le4-254le4. PMID: 25232175, DOI: 10.1126/scitranslmed.3009864.
- Arleo EK, Troiano RN, da Silva R, Greenbaum D, Kliman HJ. Utilizing Two-Dimensional Ultrasound to Develop Normative Curves for Estimated Placental Volume. American Journal Of Perinatology 2013, 31: 683-688. PMID: 24108663, DOI: 10.1055/s-0033-1357265.
- Kliman H, Milano K. The majority of miscarriages are caused by genetic abnormalities. Fertility And Sterility 2013, 100: s306. DOI: 10.1016/j.fertnstert.2013.07.996.
- Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. Trophoblast Inclusions Are Significantly Increased in the Placentas of Children in Families at Risk for Autism. Biological Psychiatry 2013, 74: 204-211. PMID: 23623455, PMCID: PMC3755347, DOI: 10.1016/j.biopsych.2013.03.006.
- Kliman H. Placenta. 2013, 2267-2275. DOI: 10.1007/978-1-4419-1698-3_1553.
- Laine K, Staff A, Murzakanova G, Gustafsson J, Barbero M, Ye S, Kliman H. OP17.03: Second trimester estimated placental volume (EPV) screening is predictive of SGA and LGA newborns and adverse pregnancy outcomes. Ultrasound In Obstetrics And Gynecology 2012, 40: 105-105. DOI: 10.1002/uog.11549.
- Rosner M, Gebb J, Ye S, Dar P, Kliman H. OP17.02: 2D Estimated Placental Volume (EPV) measurements in first trimester are reliable and correlate with measurements obtained by the 3D VOCAL™ technique. Ultrasound In Obstetrics And Gynecology 2012, 40: 105-105. DOI: 10.1002/uog.11548.
- Anders A, Campbell K, Galerneau F, Ye S, Kliman H. P16.10: Vscan portable ultrasound scanner accurately measures estimated placental volume (EPV). Ultrasound In Obstetrics And Gynecology 2012, 40: 232-233. DOI: 10.1002/uog.11979.
- Kliman H. Placental volume. BMC Pregnancy And Childbirth 2012, 12: a4. PMCID: PMC3428687, DOI: 10.1186/1471-2393-12-s1-a4.
- Kliman H. Structural abnormalities in the placenta. BMC Pregnancy And Childbirth 2012, 12: a3. PMCID: PMC3428688, DOI: 10.1186/1471-2393-12-s1-a3.
- Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R. Placental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia. Reproductive Sciences 2012, 19: 16-30. PMID: 21989657, DOI: 10.1177/1933719111424445.
- Kliman H, Campbell K, Anders A, Lee Y, Subramanyam P, Funai E, Galerneau F. 354: Estimated placental volume (EPV): generation of normative growth curves. American Journal Of Obstetrics And Gynecology 2012, 206: s166-s167. DOI: 10.1016/j.ajog.2011.10.372.
- Stephenson M, Willis M, Schultz P, Milano K, Kliman H. Abnormal nuclear cyclin E expression in endometrial glands of patients with recurrent pregnancy loss (RPL): response to vaginal micronized progesterone adminstration. Fertility And Sterility 2009, 92: s244-s245. DOI: 10.1016/j.fertnstert.2009.07.1612.
- Azpurua H, Funai E, Coraluzzi L, Doherty L, Sasson I, Kliman M, Kliman H. Determination of Placental Weight Using Two-dimensional Sonography and Volumetric Mathematic Modeling. American Journal Of Perinatology 2009, 27: 151-155. PMID: 19653142, DOI: 10.1055/s-0029-1234034.
- Lash GE, Ansari T, Bischof P, Burton GJ, Chamley L, Crocker I, Dantzer V, Desoye G, Drewlo S, Fazleabas A, Jansson T, Keating S, Kliman HJ, Lang I, Mayhew T, Meiri H, Miller RK, Nelson DM, Pfarrer C, Roberts C, Sammar M, Sharma S, Shiverick K, Strunk D, Turner MA, Huppertz B. IFPA Meeting 2008 Workshops Report. Placenta 2008, 30: 4-14. PMID: 19084270, PMCID: PMC2668143, DOI: 10.1016/j.placenta.2008.11.014.
- Funai E, Labowsky A, Drewes C, Kliman H. Timing of Fetal Meconium Absorption by Amnionic Macrophages. American Journal Of Perinatology 2008, 26: 093-097. PMID: 19031358, DOI: 10.1055/s-0028-1103028.
- Azpurua‐Pardi H, Funai E, Coraluzzi L, Sasson I, Doherty L, Kliman M, Kliman H. OP23.10: Determination of placental weight using two‐dimensional sonography and volumetric mathematic modeling. Ultrasound In Obstetrics And Gynecology 2008, 32: 391-392. DOI: 10.1002/uog.5877.
- Yusuf K, Kliman HJ. The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas. Journal Of Perinatal Medicine 2008, 36: 291-296. PMID: 18598117, DOI: 10.1515/jpm.2008.054.
- Johnston-MacAnanny E, Kliman H, Maier D, Nulsen J, Benadiva C. The role of endometrial function test (EFT®) in recurrent implantation failure (RIF) in IVF. Fertility And Sterility 2007, 88: s162. DOI: 10.1016/j.fertnstert.2007.07.563.
- Hecht JL, Kliman HJ, Allred EN, Pflueger SM, Chang C, Doss BJ, Roberts D, Livasy CA, Bhan I, Zambrano E, Ross DW, Senagore P, Husain AN, Leviton A. Reference Weights for Placentas Delivered before the 28th Week of Gestation. Placenta 2007, 28: 987-990. PMID: 17573110, DOI: 10.1016/j.placenta.2007.04.009.
- Lee L, Heitor F, Kliman H, Mcelrath T, Majzoub J. Syncytiotrophoblasts of preeclamptic placentas overexpress corticotropin-releasing hormone mRNA. American Journal Of Obstetrics And Gynecology 2006, 195: s18. DOI: 10.1016/j.ajog.2006.10.048.
- Kliman HJ, Honig S, Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients. Journal Of Assisted Reproduction And Genetics 2006, 23: 299-303. PMID: 16983518, DOI: 10.1007/s10815-006-9061-1.
- Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ. Placental Trophoblast Inclusions in Autism Spectrum Disorder. Biological Psychiatry 2006, 61: 487-491. PMID: 16806106, DOI: 10.1016/j.biopsych.2006.03.068.
- Hecht J, Onderdonk A, Delaney M, Allred E, Kliman H, Zambrano E, Solveig P, Livasy C, Bhan I, Leviton A. Characterization of chorioamnionitis in second trimester c-section placentas and correlation with microorganism recovery from sub-amniotic tissues. Pediatric And Developmental Pathology 2006, preprint: 1. DOI: 10.2350/07-06-0285.
- Catalanotti JS, Spandorfer SD, Barmat LI, Rosenwaks Z, McSweet JC, Kliman HJ. Mouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization–embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures. Fertility And Sterility 2006, 85: 255-258. PMID: 16412771, DOI: 10.1016/j.fertnstert.2005.06.060.
- Kliman H, Copperman A, Honig S, Walls D, McSweet J. Optimization of Endometrial Preparation Results in a Normal Endometrial Function Test® (EFT®) and Good Reproductive Outcome in Donor Ovum Recipients. Fertility And Sterility 2005, 84: s271-s272. DOI: 10.1016/j.fertnstert.2005.07.705.
- Willman S, Kliman H. Comparison of the Luteal Phase after Pituitary Suppression With GnRH-Agonist Versus GnRH Antagonist in Controlled Ovarian Hyperstimulation. Fertility And Sterility 2005, 84: s308. DOI: 10.1016/j.fertnstert.2005.07.806.
- Rackow B, Kliman H, Taylor H. GnRH Antagonists Do Not Affect Peri-Implantation Endometrial HOXA10 Expression. Fertility And Sterility 2005, 84: s309-s310. DOI: 10.1016/j.fertnstert.2005.07.809.
- Stephenson M, Houlihan E, Karrison T, Franco A, McSweet J, Kliman H. Successful treatment of endometrial-associated recurrent pregnancy loss (RPL): A blinded, controlled study. Fertility And Sterility 2004, 82: s79. DOI: 10.1016/j.fertnstert.2004.07.201.
- Lorch A, Franco A, McSweet J, Keefe D, Kliman H. Telomerase expression in fertile patients compared to infertile patients with thin endometria. Fertility And Sterility 2004, 82: s74. DOI: 10.1016/j.fertnstert.2004.07.189.
- Kliman HJ, Segel L. The placenta may predict the baby. Journal Of Theoretical Biology 2003, 225: 143-145. PMID: 14559066, DOI: 10.1016/s0022-5193(03)00248-0.
- Kliman H, McSweet J, Franco A, Ying X, Zhao Y, Stetten G. Trophoblast inclusions are rare in elective terminations and normal deliveries, but common in cases with karyotypic abnormalities. Fertility And Sterility 2003, 80: 88. DOI: 10.1016/s0015-0282(03)02035-1.
- Dubowy RL, Feinberg RF, Keefe DL, Doncel GF, Williams SC, McSweet JC, Kliman HJ. Improved endometrial assessment using cyclin E and p27. Fertility And Sterility 2003, 80: 146-156. PMID: 12849817, DOI: 10.1016/s0015-0282(03)00573-9.
- Kliman H. Trophoblast Toxicity Assay (TTA). 2003 DOI: 10.1201/9780203008799.ch44.
- Kliman H, McSweet J, Grunert G, Cardone V, Cadesky K, Keefe D. The endometrial function test (EFT) directs care and predicts ART outcome. Fertility And Sterility 2002, 78: s17. DOI: 10.1016/s0015-0282(02)03424-6.
- Meaddough EL, Olive DL, Gallup P, Perlin M, Kliman HJ. Sexual Activity, Orgasm and Tampon Use Are Associated with a Decreased Risk for Endometriosis. Gynecologic And Obstetric Investigation 2002, 53: 163-169. PMID: 12053101, DOI: 10.1159/000058368.
- Kliman H, McSweet J, Grunert G, Cardone V. Efficacy of the Endometrial Function Test in Assisted Reproductive Technology Practice. Obstetrics And Gynecology 2002, 99: 46s. DOI: 10.1097/00006250-200204001-00101.
- Kliman H, Olive D. Authors’ response to the Letters to the Editors concerning the article by Meaddough et al: Sexual Activity, Orgasm and Tampon Use Are Associated with a Decreased Risk for Endometriosis. Gynecologic And Obstetric Investigation 2002, 54: 65-66. DOI: 10.1159/000068357.
- Bagot C, Kliman H, Taylor H. Maternal Hoxa10 is required for pinopod formation in the development of mouse uterine receptivity to embryo implantation. Developmental Dynamics 2001, 222: 538-544. PMID: 11747087, DOI: 10.1002/dvdy.1209.
- Schwartz LB, Naftolin F, Lyttle CR, Penzias AS, Meaddough EL, Kliman HJ. Mouse ascites golgi (MAG) mucin expression and regulation by progesterone in the rat uterus. Reproductive Sciences 2001, 8: 216-23. PMID: 11525897, DOI: 10.1016/s1071-5576(01)00115-0.
- Schwartz L, Naftolin F, Lyttle C, Penzias A, Meaddough E, Kliman H. Mouse Ascites Golgi (MAG) Mucin Expression and Regulation by Progesterone in the Rat Uterus. Reproductive Sciences 2001, 8: 216-223. DOI: 10.1177/107155760100800406.
- Kliman H. Uteroplacental Blood Flow The Story of Decidualization, Menstruation, and Trophoblast Invasion. American Journal Of Pathology 2000, 157: 1759-1768. PMID: 11106547, PMCID: PMC1885765, DOI: 10.1016/s0002-9440(10)64813-4.
- Dubowy R, Feinberg R, Kliman H. Endometrial Biopsy and Infertility Evaluation: New Insights from Cyclins. Fertility And Sterility 2000, 74: s183-s184. DOI: 10.1016/s0015-0282(00)01255-3.
- Acosta A, Elberger L, Borghi M, Calamera J, Chemes H, Doncel G, Kliman H, Lema B, Lustig L, Papier S. Endometrial dating and determination of the window of implantation in healthy fertile women. Fertility And Sterility 2000, 73: 788-798. PMID: 10731542, DOI: 10.1016/s0015-0282(99)00605-6.
- Kliman H, Barmat L, Wang F. P-134 MAG mucin expression abnormalities in natural cycle biopsies predict subsequent IVF failure. Fertility And Sterility 1997, 68: s156. DOI: 10.1016/s0015-0282(97)90949-3.
- P-060 Estrogen treatment converts MAG-negative (unreceptive) endometrium to MAG-positive (receptive)Kliman H, VanDeerlin P, Feinberg R. P-060 Estrogen treatment converts MAG-negative (unreceptive) endometrium to MAG-positive (receptive). Fertility And Sterility 1997, 68: s120-s121. DOI: 10.1016/s0015-0282(97)90876-1.
- Kliman H, Feinberg R, VanDeerlin P, Barmat L, Moomjy M, Keefe D, Wang F, Olive D. P-009 Glandular developmental arrest (GDA): A unifying model of reproductive endometrial pathology. Fertility And Sterility 1997, 68: s96-s97. DOI: 10.1016/s0015-0282(97)90826-8.
- Keltz M, Attar E, Buradagunta S, Olive D, Kliman H, Arici A. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube. American Journal Of Obstetrics And Gynecology 1996, 175: 1611-1619. PMID: 8987949, DOI: 10.1016/s0002-9378(96)70114-x.
- Nachtigall MJ, Kliman HJ, Feinberg RF, Olive DL, Engin O, Arici A. The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 801-806. PMID: 8636307, DOI: 10.1210/jcem.81.2.8636307.
- Arici A, Tazuke SI, Attar E, Kliman HJ, Olive DL. Endocrinology and paracrinology. Molecular Human Reproduction 1996, 2: 40-45. PMID: 9238656, DOI: 10.1093/molehr/2.1.40.
- Kliman H, Perrotta P, Jones D. The efficacy of the placental biopsy. American Journal Of Obstetrics And Gynecology 1995, 173: 1084-1088. PMID: 7485298, DOI: 10.1016/0002-9378(95)91331-9.
- Keltz M, Kliman H, Arici A, Olive D. Endosalpingiosis found at laparoscopy for chronic pelvic pain**Presented at the 50th Annual Meeting of The American Fertility Society Meeting, San Antonio, Texas, November 5 to 10, 1994. Fertility And Sterility 1995, 64: 482-485. PMID: 7641898, DOI: 10.1016/s0015-0282(16)57780-2.
- Feinberg R, Kliman H, Bedian V, Monzon-Bordonaba F, Menzin A, Wang C. Monoclonal antibody X18A4 identifies on oncofetal fibronectin epitope distinct from the FDC-6 binding site. American Journal Of Obstetrics And Gynecology 1995, 172: 1526-1536. PMID: 7538728, DOI: 10.1016/0002-9378(95)90491-3.
- Bahado-Singh RO, Kliman H, Feng TY, Hobbins J, Copel JA, Mahoney MJ. First-trimester endocervical irrigation: feasibility of obtaining trophoblast cells for prenatal diagnosis. Obstetrics And Gynecology 1995, 85: 461-4. PMID: 7862393, DOI: 10.1016/0029-7844(94)00416-b.
- Kliman HJ, Feinberg RF, Schwartz LB, Feinman MA, Lavi E, Meaddough EL. A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium. American Journal Of Pathology 1995, 146: 166-81. PMID: 7531946, PMCID: PMC1870765.
- Rotmensch S, Liberati M, Luo J, Kliman H, Gollin Y, Bellati U, Hobbins J, Copel J. Color Doppler flow patterns and flow velocity waveforms of the intraplacental fetal circulation in growth-retarded fetuses. American Journal Of Obstetrics And Gynecology 1994, 171: 1257-1264. PMID: 7977530, DOI: 10.1016/0002-9378(94)90143-0.
- Kliman H. Trophoblast infiltration. Reproductive Medicine Review 1994, 3: 137-157. DOI: 10.1017/s0962279900000831.
- Feinberg RF, Kliman HJ, Wang CL. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 1241-1248. PMID: 8175984, DOI: 10.1210/jcem.78.5.8175984.
- Kliman HJ. The placenta revealed. American Journal Of Pathology 1993, 143: 332-6. PMID: 8342590, PMCID: PMC1887036.
- Feinberg R, Kliman H, Wang C. Transforming growth factor beta (TGFβ) stimulates tropho-uteronectin (TUN) synthesis and trophoblast adhesiveness in vitro. Placenta 1993, 14: a21. DOI: 10.1016/s0143-4004(05)80507-7.
- Kliman H, Arici A, Cunningham M, Meaddough E. Chorioamnionitis: A role for interleukin-8? Placenta 1993, 14: a37. DOI: 10.1016/s0143-4004(05)80540-5.
- Feinberg R, Kliman H. Tropho-uteronectin (tun): A unique oncofetal fibronectin deposited in the extracellular matrix of the tropho-uterine junction and regulated in vitro by cultured human trophoblast cells. Placenta 1993, 14: 167-179. DOI: 10.1016/s0143-4004(05)80292-9.
- Schwartz L, Meaddough E, Lyttle C, Penzias A, Naftolin F, Kliman H. Rat mouse ascites golgi (MAG) factor: A potential, animal model for studying endometrial receptivity to implantation. Placenta 1992, 13: a57. DOI: 10.1016/0143-4004(92)90175-s.
- Kliman H, Feinberg R, Meaddough E, Schwartz L. Mouse ascites Golgi (MAG) factor: A mucin which may be a potential menstrual cycle dependent marker of endometrial receptivity to human implantation. Placenta 1992, 13: a35. DOI: 10.1016/0143-4004(92)90131-c.
- Feinberg RF, Kliman HJ. Fetal Fibronectin and Preterm Labor. New England Journal Of Medicine 1992, 326: 708-709. PMID: 1736115, DOI: 10.1056/nejm199203053261013.
- Kliman H, Feinberg R. Differentiation of the Trophoblast. 1992, 3-25. DOI: 10.1007/978-3-642-84385-3_1.
- Feinberg RF, Kliman HJ, Cohen AW. Preeclampsia, trisomy 13, and the placental bed. Obstetrics And Gynecology 1991, 78: 505-8. PMID: 1870809.
- Lavi E, Montone K, Rorke L, Kliman H. Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage. Neurology 1991, 41: 1467-8. PMID: 1891100, DOI: 10.1212/wnl.41.9.1467.
- COUTIFARIS C, BABALOLA GO, ABISOGUN AO, KAO L, CHIN U, VADILLO‐ORTEGA F, OSHEROFF J, KLIMAN HJ, STRAUSS JF. In Vitro Systems for the Study of Human Trophoblast Implantation. Annals Of The New York Academy Of Sciences 1991, 622: 191-201. PMID: 2064180, DOI: 10.1111/j.1749-6632.1991.tb37862.x.
- Feinberg RF, Kliman HJ, Lockwood CJ. Is oncofetal fibronectin a trophoblast glue for human implantation? American Journal Of Pathology 1991, 138: 537-43. PMID: 2000933, PMCID: PMC1886265.
- Kliman H, Feinberg R, Haimowitz J. Human trophoblast-endometrial interactions in an in vitro suspension culture system. Placenta 1990, 11: 349-367. PMID: 2235916, DOI: 10.1016/s0143-4004(05)80226-7.
- Kliman HJ, Feinberg RF. Human trophoblast-extracellular matrix (ECM) interactions in vitro: ECM thickness modulates morphology and proteolytic activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 3057-3061. PMID: 2326266, PMCID: PMC53833, DOI: 10.1073/pnas.87.8.3057.
- Coutifaris C, Babalola G, Feinberg R, Kao L, Kliman H, Strauss J. Purified Human Cytotrophoblasts: Surrogates for The Blastocyst in In Vitro Models of Implantation? 1990, 687-695. DOI: 10.1007/978-1-4613-0645-0_74.
- Babalola G, Coutifaris C, Soto E, Kliman H, Shuman H, Strauss J. Aggregation of dispersed human cytotrophoblastic cells: Lessons relevant to the morphogenesis of the placenta. Developmental Biology 1990, 137: 100-108. PMID: 2295358, DOI: 10.1016/0012-1606(90)90011-7.
- Kliman H, Feinberg R, Strauss J, Haimowitz J. Interactions between human term trophoblasts and endometrium in vitro. Placenta 1989, 10: 453-454. DOI: 10.1016/0143-4004(89)90057-x.
- Feinberg R, Haimowitz J, Kliman H. Human trophoblast interaction with the extracellular matrix: A histologic assay system for studying trophoblast invasion. Placenta 1989, 10: 454-455. DOI: 10.1016/0143-4004(89)90058-1.
- Feinberg RF, Kao LC, Haimowitz JE, Queenan JT, Wun TC, Strauss JF, Kliman HJ. Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Laboratory Investigation 1989, 61: 20-6. PMID: 2473276.
- Nulsen JC, Silavin SL, Kao LC, Ringler GE, Kliman HJ, Strauss JF. Control of the steroidogenic machinery of the human trophoblast by cyclic AMP. Society Of Reproduction And Fertility 1989, 37: 147-53. PMID: 2553955.
- Kliman HJ, Coutifaris C, Babalola GO, Soto EA, Kao LC, Queenan JT, Feinberg RF, Strauss JF. The human trophoblast: homotypic and heterotypic cell-cell interactions. Progress In Clinical And Biological Research 1989, 294: 425-34. PMID: 2726976.
- Feinman M, Kliman H, Main E. HLA antigen expression and induction by gamma‐interferon in cultured human trophoblast. International Journal Of Gynecology & Obstetrics 1988, 27: 481-481. DOI: 10.1016/0020-7292(88)90155-5.
- Kao L, Caltabiano S, Wu S, Strauss J, Kliman H. The human villous cytotrophoblast: Interactions with extracellular matrix proteins, endocrine function, and cytoplasmic differentiation in the absence of syncytium formation. Developmental Biology 1988, 130: 693-702. PMID: 2848742, DOI: 10.1016/0012-1606(88)90361-2.
- ROY‐CHOUDHURY S, SEN‐MAJUMDAR A, MURTHY U, MISHRA V, KLIMAN H, NESTLER J, STRAUSS J, Manjusri D. Biosynthesis and turnover of a 34‐kDa protein growth factor in human cytotrophoblasts. The FEBS Journal 1988, 172: 777-783. PMID: 3350024, DOI: 10.1111/j.1432-1033.1988.tb13957.x.
- Feinman M, Kliman H, Main E. HLA antigen expression and induction by γ-interferon in cultured human trophoblasts. American Journal Of Obstetrics And Gynecology 1987, 157: 1429-1434. PMID: 3122576, DOI: 10.1016/s0002-9378(87)80238-7.
- ULLOA-AGUIRRE A, AUGUST A, GOLOS T, KAO L, SAKURAGI N, KLIMAN H, STRAUSS J. 8-Bromo-Adenosine 3′,5′Monophosphate Regulates Expression of Chorionic Gonadotropin and Fibronectin in Human Cytotrophoblasts*. The Journal Of Clinical Endocrinology & Metabolism 1987, 64: 1002-1009. PMID: 2435752, DOI: 10.1210/jcem-64-5-1002.
- Kliman H, Feinman M, Strauss J. Differentiaton of Human Cytotrophoblast into Syncytiotrophoblast in Culture. Trophoblast Research 1987, 407-421. DOI: 10.1007/978-1-4757-1936-9_29.
- FEINMAN M, KLIMAN H, CALTABIANO S, STRAUSS J. 8-Bromo-3′5′ -Adenosine Monophosphate Stimulates the Endocrine Activity of Human Cytotrophoblasts in Culture*. The Journal Of Clinical Endocrinology & Metabolism 1986, 63: 1211-1217. PMID: 3531221, DOI: 10.1210/jcem-63-5-1211.
- Soto E, Kliman H, Strauss J, Paavola L. Gonadotropins and Cyclic Adenosine 3′,5′-Monophosphate (cAMP) Alter the Morphology of Cultured Human Granulosa Cells. Biology Of Reproduction 1986, 34: 559-569. PMID: 3008869, DOI: 10.1095/biolreprod34.3.559.
- KLIMAN H, NESTLER J, SERMASI E, SANGER J, STRAUSS J. Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*. Endocrinology 1986, 118: 1567-1582. PMID: 3512258, DOI: 10.1210/endo-118-4-1567.
- Ballas S, Kliman H, Smith E. Glyceraldehyde-3-phosphate dehydrogenase of rat erythrocytes has no membrane component. Biochimica Et Biophysica Acta 1985, 831: 142-149. PMID: 4041465, DOI: 10.1016/0167-4838(85)90161-x.
- Kliman HJ, Steck TL. Association of glyceraldehyde-3-phosphate dehydrogenase with the human red cell membrane. A kinetic analysis. Journal Of Biological Chemistry 1980, 255: 6314-6321. PMID: 7391020, DOI: 10.1016/s0021-9258(18)43739-8.
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