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Clinical Neuroscience Research Unit
Connecticut Mental Health Center
34 Park Street
New Haven, CT 06519
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- Clinical Neuroscience Research UnitConnecticut Mental Health Center34 Park StreetNew Haven, CT 06519
- Yale Depression Research Clinic100 York StreetSte 2JNew Haven, CT 06511
- Interventional PsychiataryYale New Haven Hospital - West Pavilion1 Park StreetNew Haven, CT 06504
Gerard Sanacora, PhD, MD
Psychiatry
Telehealth is available
Patient type treated
Child, Adult
Accepting new patients
No
Referral required
Not Applicable
Board Certified in
Psychiatry
Biography
Dr. Sanacora is a Professor of Psychiatry at Yale University and the Director of the Yale Depression Research Program. Dr. Sanacora’s work has focused largely on elucidating the pathophysiological mechanisms associated with mood and other neuropsychiatric disorders and using this information to inform the development of novel treatment strategies. His preclinical research laboratory explores the effects of stress and pharmaceutical agents on cellular biology, neurophysiology and behavior. His clinical laboratory employs novel imaging methodologies to investigate the pathophysiology of mood and other neuropsychiatric disorders. In addition, he has served as principal investigator on several large clinical trials investigating the efficacy and safety of newly developed therapeutic agents for the treatment of mood disorders. Dr. Sanacora received the Anna-Monkia Stiftung international award for the investigation of the biological substrate and functional disturbances of depression in 2009, the Joel Elkes Research Award for Outstanding contributions to Psychopharmacology from the American College of Neuropsychopharmacology (ACNP) in 2011, and is a Fellow of the ACNP.
Titles
- George D. and Esther S. Gross Professor of Psychiatry
- Director, Yale Depression Research Program
- Co-Director, Yale New Haven Hospital Interventional Psychiatry Service
Education & Training
- FellowYale University School of Medicine (1999)
- ResidentYale University School of Medicine (1998)
- MDSUNY at Stonybrook (1994)
- PhDSUNY at Stonybrook (1992)
- Post DoctoralSUNY Stony Brook (1992)
Additional Information
Honors & Recognitions
- Team Science Award: Association for Clinical and Translational Science (ACTS) (2022)
- Joel Elkes Research Award for outstanding contributions to Psychopharmacology: American College of Neuropsychopharmacology (2011)
- ANNA-MONIKA-FOUNDATION Award for the investigation of the biological substrate and functional disturbances of depression: ANNA-MONIKA-FOUNDATION (2009)
- Klerman Award, Honorable Mention Breakthroughs in Basic Brian & Behavior Science: NARSAD (2005)
- Klerman Award, Honorable Mention Outstanding Research Project: NARSAD (2003)
Publications
- Leal G, Souza-Marques B, Mello R, Bandeira I, Caliman-Fontes A, Carneiro B, Faria-Guimarães D, Guerreiro-Costa L, Jesus-Nunes A, Silva S, Lins-Silva D, Fontes M, Alves-Pereira R, Cordeiro V, Rugieri-Pacheco S, Santos-Lima C, Correia-Melo F, Vieira F, Sanacora G, Lacerda A, Quarantini L. Arketamine as adjunctive therapy for treatment-resistant depression: A placebo-controlled pilot study Journal Of Affective Disorders 2023, 330: 7-15. PMID: 36871913, DOI: 10.1016/j.jad.2023.02.151.
- Bansal Y, Fee C, Misquitta K, Codeluppi S, Sibille E, Berman R, Coric V, Sanacora G, Banasr M. Prophylactic efficacy of riluzole against anxiety- and depressive-like behaviors in two rodent stress models Complex Psychiatry 2023 DOI: 10.1159/000529534.
- Feeney A, Hoeppner B, Freeman M, Flynn M, Iosifescu D, Trivedi M, Sanacora G, Mathew S, DeBattista C, Ionescu D, Cusin C, Papakostas G, Jha M, Fava M. Effect of Concomitant Benzodiazepines on the Antidepressant Effects of Ketamine The Journal Of Clinical Psychiatry 2022, 84 DOI: 10.4088/jcp.22m14991.
- Feeney A, Hoeppner B, Freeman M, Flynn M, Iosifescu D, Trivedi M, Sanacora G, Mathew S, DeBattista C, Ionescu D, Cusin C, Papakostas G, Jha M, Fava M. Effect of Concomitant Benzodiazepines on the Antidepressant Effects of Ketamine: Findings From the RAPID Intravenous Ketamine Study. The Journal Of Clinical Psychiatry 2022, 84 PMID: 36383742, DOI: 10.4088/jcp.22m14491.
- Holmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in quantification of the metabotropic glutamate receptor 5 (mGluR5) across bipolar disorder and major depressive disorder Biological Psychiatry 2022 PMID: 36764853, DOI: 10.1016/j.biopsych.2022.10.018.
- Holmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in quantification of the metabotropic glutamate receptor 5 (mGluR5) across bipolar disorder and major depressive disorder Biological Psychiatry 2022 DOI: 10.1016/j.biopsych.2022.10.018.
- Holmes S, Finnema S, Naganawa M, DellaGioia N, Holden D, Fowles K, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita G, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. Imaging the Effect of Ketamine on Synaptic (SV2A) Density Biological Psychiatry 2021, 89: s35. DOI: 10.1016/j.biopsych.2021.02.105.
- Dwyer J, Landeros-Weisenberger A, Johnson J, Tobon A, Flores J, Nasir M, Couloures K, Sanacora G, Bloch M. Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial FOCUS The Journal Of Lifelong Learning In Psychiatry 2021, 20: 241-251. DOI: 10.1176/appi.focus.22020004.
- Holmes S, Scheinost D, Finnema S, Naganawa M, Davis M, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Pietrzak R, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. 142. Synaptic Density Alterations are Associated With Depression Severity and Network Alterations Biological Psychiatry 2019, 85: s59. DOI: 10.1016/j.biopsych.2019.03.156.
- Webler R, Wilkinson S, Kirwin D, Bloch M, Kitay B, Sanacora G. S128. Expectancy and Ketamine’s Rapid Antidepressant Effect: A Meta-Analysis Biological Psychiatry 2019, 85: s346. DOI: 10.1016/j.biopsych.2019.03.879.
- Krystal A, Pizzagalli D, Smoski M, Mathew S, Nurnberger J, Lisanby S, Iosifescu D, Murrough J, Weiner R, Calabrese J, Sanacora G, Keefe R, Song A, Goodman W, Szabo S, Whitten A, Gao K, Potter W. 116. Results of the NIMH FAST-MAS Phase IIa Proof of Mechanism Study of the Effects of the Selective κ Opioid Antagonist JNJ-67953964 on fMRI Ventral Striatal Activity in Anhedonic Patients Biological Psychiatry 2019, 85: s48-s49. DOI: 10.1016/j.biopsych.2019.03.130.
- Ochs-Ross R, Daly E, Zhang Y, Lane R, Lim P, Foster K, Hough D, Manji H, Drevets W, Sanacora G, Adler C, McShane R, Gaillard R, Singh J. POST HOC ANALYSES OF ESKETAMINE NASAL SPRAY PLUS AN ORAL ANTIDEPRESSANT IN ELDERLY PATIENTS WITH TREATMENT-RESISTANT DEPRESSION American Journal Of Geriatric Psychiatry 2019, 27: s140-s141. DOI: 10.1016/j.jagp.2019.01.094.
- Ochs-Ross R, Daly E, Zhang Y, Lane R, Lim P, Foster K, Hough D, Manji H, Drevets W, Sanacora G, Adler C, McShane R, Gaillard R, Singh J. EFFICACY AND SAFETY OF ESKETAMINE NASAL SPRAY PLUS AN ORAL ANTIDEPRESSANT IN ELDERLY PATIENTS WITH TREATMENT-RESISTANT DEPRESSION American Journal Of Geriatric Psychiatry 2019, 27: s139-s140. DOI: 10.1016/j.jagp.2019.01.093.
- Sanacora G, Kitay B, Wilkinson S. Chapter 35 The Search for Rapid Acting Antidepressants: Research Synthesis and Perspectives 2019, 401-413. DOI: 10.1016/b978-0-12-813333-0.00035-4.
- Wajs E, Leah A, Morrison R, Daly E, Lane R, Lim P, Holder R, Sanacora G, Young A, Kasper S, Sulaiman A, Li C, Paik J, Manji H, Hough D, Drevets W, Singh J. Long-term safety of esketamine nasal spray plus oral antidepressant in patients with treatment-resistant depression: SUSTAIN-2 phase 3 study European Neuropsychopharmacology 2019, 29: s44-s45. DOI: 10.1016/j.euroneuro.2018.11.1016.
- Ochs-Ross R, Daly E, Zhang Y, Lane R, Lim P, Foster K, Hough D, Manji H, Drevets W, Sanacora G, Adler C, McShane R, Gaillard R, Singh J. Efficacy and safety of esketamine nasal spray plus an oral antidepressant in elderly patients with treatment-resistant depression European Neuropsychopharmacology 2019, 29: s355-s356. DOI: 10.1016/j.euroneuro.2018.11.548.
- Wajs E, Aluisio L, Morrison R, Daly E, Lane R, Lim P, Holder R, Sanacora G, Young A, Kasper S, Sulaiman A, Li C, Paik J, Manji H, Hough D, Drevets W, Singh J. Etude de phase 3 en ouvert évaluant l’efficacité et la sécurité d’emploi à long terme d’Eskétamine intranasal (ESK IN) associé à un antidépresseur oral chez des patients atteints de dépression résistante (SUSTAIN-2) French Journal Of Psychiatry 2018, 1: s176. DOI: 10.1016/s2590-2415(19)30445-3.
- Holmes S, Finnema S, Davis M, DellaGioia N, Naganawa M, Nabulsi N, Matuskey D, Pietrzak R, Duman R, Sanacora G, Carson R, Esterlis I. F149. Preliminary Evidence for Altered Synaptic Density and a Possible Role for Accelerated Ageing in Individuals With MDD as Measured With [11C]UCB-J PET Biological Psychiatry 2018, 83: s296. DOI: 10.1016/j.biopsych.2018.02.763.
- Wilkinson S, Webler R, Katz R, Toprak M, Ostroff R, Sanacora G. S106. Acute and Longer-Term Outcomes Using Ketamine as a Clinical Treatment at the Yale Psychiatric Hospital Biological Psychiatry 2018, 83: s388. DOI: 10.1016/j.biopsych.2018.02.997.
- Ochs-Ross R, Daly E, Zhang Y, Lane R, Lim P, Foster K, Hough D, Manji H, Drevets W, Sanacora G, Adler C, McShane R, Gaillard R, Singh J. S114. Efficacy and Safety of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Patients With Treatment-Resistant Depression Biological Psychiatry 2018, 83: s391. DOI: 10.1016/j.biopsych.2018.02.1005.
- Sanacora G, Chowdhury G, Rothman D, Behar K. 662 Ketamine and Rapastinel Effects on Glutamate Cycling Biological Psychiatry 2017, 81: s268. DOI: 10.1016/j.biopsych.2017.02.1071.
- Dwyer J, Sanacora G, Bloch M. 1002 Ketamine as a Treatment for Adolescent Major Depressive Disorder Biological Psychiatry 2017, 81: s405. DOI: 10.1016/j.biopsych.2017.02.729.
- Sanacora G, Wilkinson S, Van Schalkwyk G. 201 Measuring Dissociative Effects of NMDA Receptor Antagonists in the Treatment of Depression Biological Psychiatry 2017, 81: s83. DOI: 10.1016/j.biopsych.2017.02.214.
- Ostroff R, Wilkinson S, Sanacora G. Computer-assisted cognitive behavior therapy to prevent relapse following electroconvulsive therapy Brain Stimulation 2017, 10: 524. DOI: 10.1016/j.brs.2017.01.529.
- Hermes G, Sanacora G. Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies 2016, 73-98. DOI: 10.1007/978-3-319-42925-0_6.
- Sanacora G, Heimer H, Hartman D, Mathew S, Frye M, Nemeroff C, Robinson Beale R. Balancing the Promise and Risks of Ketamine Treatment for Mood Disorders Neuropsychopharmacology 2016, 42: 1179-1181. PMID: 27640324, PMCID: PMC5437876, DOI: 10.1038/npp.2016.193.
- Krystal J, Sanacora G, Abdallah C, Duman R. Speaker 4: John Krystal, USA The International Journal Of Neuropsychopharmacology 2016, 19: 19-19. PMCID: PMC5616528, DOI: 10.1093/ijnp/pyw042.052.
- Singh J, Fedgchin M, Daly E, De Boer P, Cooper K, Lim P, Pinter C, Murrough J, Sanacora G, Shelton R, Kurian B, Winokur A, Fava M, Manji H, Drevets W, Van Nueten L. P.2.b.017 Onset of efficacy of ketamine in treatment-resistant depression: a double-blind, randomised, placebo-controlled, dose frequency study European Neuropsychopharmacology 2014, 24: s387-s388. DOI: 10.1016/s0924-977x(14)70618-2.
- Kiselycznyk C, Sanacora G. Using Our Understanding of Stress-Related Effects on Glutamate Neurotransmission to Guide the Development of Novel Treatment Strategies 2014, 313-341. DOI: 10.1007/978-1-4939-1056-4_17.
- Sanacora G, Duman R. The Revolution in Rapid-Acting Antidepressants Biological Psychiatry 2013, 73: 1123-1124. DOI: 10.1016/j.biopsych.2013.04.020.
- Abdallah CG, Fasula M, Kelmendi B, Sanacora G, Ostroff R. Rapid Antidepressant Effect of Ketamine in the Electroconvulsive Therapy Setting Journal Of Ect 2012, 28: 157-161. PMID: 22847373, PMCID: PMC3426617, DOI: 10.1097/yct.0b013e31824f8296.
- Laje G, Lally N, Mathews D, Brutsche N, Chemerinski A, Akula N, Kelmendi B, Simen A, McMahon FJ, Sanacora G, Zarate C. Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Antidepressant Efficacy of Ketamine in Depressed Patients Biological Psychiatry 2012, 72: e27-e28. PMID: 22771240, PMCID: PMC3786174, DOI: 10.1016/j.biopsych.2012.05.031.
- Morgan PT, Pace-Schott EF, Mason GF, Forselius E, Fasula M, Valentine GW, Sanacora G. Cortical GABA Levels in Primary Insomnia Sleep 2012, 35: 807-814. PMID: 22654200, PMCID: PMC3353043, DOI: 10.5665/sleep.1880.
- Chowdhury GM, Behar KL, Cho W, Thomas MA, Rothman DL, Sanacora G. 1H-[13C]-Nuclear Magnetic Resonance Spectroscopy Measures of Ketamine's Effect on Amino Acid Neurotransmitter Metabolism Biological Psychiatry 2011, 71: 1022-1025. PMID: 22169441, PMCID: PMC3660962, DOI: 10.1016/j.biopsych.2011.11.006.
- Popoli M, Yan Z, McEwen BS, Sanacora G. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission Nature Reviews Neuroscience 2011, 13: 22-37. PMID: 22127301, PMCID: PMC3645314, DOI: 10.1038/nrn3138.
- Larkin G, Beautrais A, Turelli R, Sanacora G, Powsner S, Lippmann M, Krystal J. P03-437 - A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department European Psychiatry 2011, 26: 1607. DOI: 10.1016/s0924-9338(11)73311-9.
- Valentine GW, Mason GF, Gomez R, Fasula M, Watzl J, Pittman B, Krystal JH, Sanacora G. The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [1H]-MRS Psychiatry Research 2011, 191: 122-127. PMID: 21232924, PMCID: PMC3061550, DOI: 10.1016/j.pscychresns.2010.10.009.
- Larkin G, Beautrais A, Powsner S, Sanacora G, Krystal J, Turelli R, Lippmann M. 157: A Prospective Open Label Trial of Low Dose Ketamine for Acute Suicidal States In the Emergency Department Annals Of Emergency Medicine 2010, 56: s53. DOI: 10.1016/j.annemergmed.2010.06.204.
- Sanacora G, Banasr M, Chowdhury G, Lepak A, Behar K. S.28.05 Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioural deficits by the glutamate-modulating drug riluzole European Neuropsychopharmacology 2010, 20: s208. DOI: 10.1016/s0924-977x(10)70241-8.
- Saricicek A, Maloney K, Lorberg B, Muralidharan A, Ruf B, Blumberg H, Hu J, Pittman B, Sanacora G, Bhagwagar Z. P.2.e.029 Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo controlled trial European Neuropsychopharmacology 2009, 19: s465. DOI: 10.1016/s0924-977x(09)70728-x.
- Banasr M, Chowdhury GM, Terwilliger R, Newton SS, Duman RS, Behar KL, Sanacora G. Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole Molecular Psychiatry 2008, 15: 501-511. PMID: 18825147, PMCID: PMC3347761, DOI: 10.1038/mp.2008.106.
- Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders Nature Reviews Drug Discovery 2008, 7: 426-437. PMID: 18425072, PMCID: PMC2715836, DOI: 10.1038/nrd2462.
- Neumeister A, Charney D, Sanacora G, Krystal J. Neurobiology and Treatment of Depression 2007 DOI: 10.1002/9780470101001.hcn018.
- Sanacora G. Evidence for GABAergic and Glutamatergic Involvement in the Pathophysiology and Treatment of Depressive Disorders 2002, 739-749. DOI: 10.1002/0470854871.chxviii3.
- Krystal J, D'Souza D, Sanacora G, Goddard A, Charney D. CURRENT PERSPECTIVES ON THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA, DEPRESSION, AND ANXIETY DISORDERS Medical Clinics Of North America 2001, 85: 559-577. PMID: 11349473, DOI: 10.1016/s0025-7125(05)70329-1.
- Chen A, Shin K, Duman R, Sanacora G. ECS-Induced Mossy Fiber Sprouting and BDNF Expression Are Attenuated By Ketamine Pretreatment Journal Of Ect 2001, 17: 27-32. PMID: 11281511, DOI: 10.1097/00124509-200103000-00006.
- Berman R, Sanacora G, Narasimhan M, Oren D, Cappiello A, Charney D. 268. Simultaneous catecholamine and indoleamine depletion in unmedicated depressed subjects Biological Psychiatry 2000, 47: s81. DOI: 10.1016/s0006-3223(00)00532-1.
- Mason G, Sanacora G, Anand A, Epperson C, Goddard A, Rothman D, Charney D, Krystal J. 304. Cortical GABA reduced in unipolar but not bipolar depression Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00568-0.
- Sanacora G, Mason G, Rothman D, Epperson C, Goddard A, Krystal J. 305. Reduced cortical GABA in depression is not due to decreased gray matter Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00569-2.
- Berman R, Narasimhan M, Sanacora G, Miano A, Hoffman R, Hu X, Charney D, Boutros N. A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression Biological Psychiatry 2000, 47: 332-337. PMID: 10686268, DOI: 10.1016/s0006-3223(99)00243-7.
- Sanacora G, Mason G, Krystal J. Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies Critical Reviews In Neurobiology 2000, 14: 23. PMID: 11253954, DOI: 10.1615/critrevneurobiol.v14.i1.20.
- Sanacora G, Rothman D, Krystal J. Applications of Magnetic Resonance Spectroscopy to Psychiatry The Neuroscientist 1999, 5: 192-196. DOI: 10.1177/107385849900500316.
- Sanacora G, Mason G, Rothman D, Berman R, Charney D, Ciarcia J, Krystal J. 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS Journal Of Ect 1999, 15: 102. DOI: 10.1097/00124509-199903000-00009.
- Sanacora G, Chen A, Shin K, Duman R. 8. Ketamine Effects on ECS Induced BDNF Expression and Mossy Fiber Sprouting Journal Of Ect 1999, 15: 109. DOI: 10.1097/00124509-199903000-00028.
- Malison R, Price L, Berman R, van Dyck C, Pelton G, Carpenter L, Sanacora G, Owens M, Nemeroff C, Rajeevan N, Baldwin R, Seibyl J, Innis R, Charney D. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography Biological Psychiatry 1998, 44: 1090-1098. PMID: 9836013, DOI: 10.1016/s0006-3223(98)00272-8.
- Sanacora G, Goddard A, Gil R, D'Souza D, Abi-Saab W, Petroff O, Mattson R, Mason G, Behar K, Ciarcia J, Berman R, Charney D, Rothman D, Krystal J. 24. Quantification of cortical GABA levels in neuropsychiatric patients Biological Psychiatry 1998, 43: s8. DOI: 10.1016/s0006-3223(98)90472-3.
- Berman R, Boutros N, Narasimhan M, Sanacora G, Charney D. 322. Transcranial magnetic stimulation in treatment-refractory depression Biological Psychiatry 1998, 43: s97. DOI: 10.1016/s0006-3223(98)90770-3.
Patient Care Organizations
Biography
Dr. Sanacora is a Professor of Psychiatry at Yale University and the Director of the Yale Depression Research Program. Dr. Sanacora’s work has focused largely on elucidating the pathophysiological mechanisms associated with mood and other neuropsychiatric disorders and using this information to inform the development of novel treatment strategies. His preclinical research laboratory explores the effects of stress and pharmaceutical agents on cellular biology, neurophysiology and behavior. His clinical laboratory employs novel imaging methodologies to investigate the pathophysiology of mood and other neuropsychiatric disorders. In addition, he has served as principal investigator on several large clinical trials investigating the efficacy and safety of newly developed therapeutic agents for the treatment of mood disorders. Dr. Sanacora received the Anna-Monkia Stiftung international award for the investigation of the biological substrate and functional disturbances of depression in 2009, the Joel Elkes Research Award for Outstanding contributions to Psychopharmacology from the American College of Neuropsychopharmacology (ACNP) in 2011, and is a Fellow of the ACNP.
Titles
- George D. and Esther S. Gross Professor of Psychiatry
- Director, Yale Depression Research Program
- Co-Director, Yale New Haven Hospital Interventional Psychiatry Service
Education & Training
- FellowYale University School of Medicine (1999)
- ResidentYale University School of Medicine (1998)
- MDSUNY at Stonybrook (1994)
- PhDSUNY at Stonybrook (1992)
- Post DoctoralSUNY Stony Brook (1992)
Additional Information
Honors & Recognitions
- Team Science Award: Association for Clinical and Translational Science (ACTS) (2022)
- Joel Elkes Research Award for outstanding contributions to Psychopharmacology: American College of Neuropsychopharmacology (2011)
- ANNA-MONIKA-FOUNDATION Award for the investigation of the biological substrate and functional disturbances of depression: ANNA-MONIKA-FOUNDATION (2009)
- Klerman Award, Honorable Mention Breakthroughs in Basic Brian & Behavior Science: NARSAD (2005)
- Klerman Award, Honorable Mention Outstanding Research Project: NARSAD (2003)
Publications
- Leal G, Souza-Marques B, Mello R, Bandeira I, Caliman-Fontes A, Carneiro B, Faria-Guimarães D, Guerreiro-Costa L, Jesus-Nunes A, Silva S, Lins-Silva D, Fontes M, Alves-Pereira R, Cordeiro V, Rugieri-Pacheco S, Santos-Lima C, Correia-Melo F, Vieira F, Sanacora G, Lacerda A, Quarantini L. Arketamine as adjunctive therapy for treatment-resistant depression: A placebo-controlled pilot study Journal Of Affective Disorders 2023, 330: 7-15. PMID: 36871913, DOI: 10.1016/j.jad.2023.02.151.
- Bansal Y, Fee C, Misquitta K, Codeluppi S, Sibille E, Berman R, Coric V, Sanacora G, Banasr M. Prophylactic efficacy of riluzole against anxiety- and depressive-like behaviors in two rodent stress models Complex Psychiatry 2023 DOI: 10.1159/000529534.
- Feeney A, Hoeppner B, Freeman M, Flynn M, Iosifescu D, Trivedi M, Sanacora G, Mathew S, DeBattista C, Ionescu D, Cusin C, Papakostas G, Jha M, Fava M. Effect of Concomitant Benzodiazepines on the Antidepressant Effects of Ketamine The Journal Of Clinical Psychiatry 2022, 84 DOI: 10.4088/jcp.22m14991.
- Feeney A, Hoeppner B, Freeman M, Flynn M, Iosifescu D, Trivedi M, Sanacora G, Mathew S, DeBattista C, Ionescu D, Cusin C, Papakostas G, Jha M, Fava M. Effect of Concomitant Benzodiazepines on the Antidepressant Effects of Ketamine: Findings From the RAPID Intravenous Ketamine Study. The Journal Of Clinical Psychiatry 2022, 84 PMID: 36383742, DOI: 10.4088/jcp.22m14491.
- Holmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in quantification of the metabotropic glutamate receptor 5 (mGluR5) across bipolar disorder and major depressive disorder Biological Psychiatry 2022 PMID: 36764853, DOI: 10.1016/j.biopsych.2022.10.018.
- Holmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in quantification of the metabotropic glutamate receptor 5 (mGluR5) across bipolar disorder and major depressive disorder Biological Psychiatry 2022 DOI: 10.1016/j.biopsych.2022.10.018.
- Holmes S, Finnema S, Naganawa M, DellaGioia N, Holden D, Fowles K, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita G, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. Imaging the Effect of Ketamine on Synaptic (SV2A) Density Biological Psychiatry 2021, 89: s35. DOI: 10.1016/j.biopsych.2021.02.105.
- Dwyer J, Landeros-Weisenberger A, Johnson J, Tobon A, Flores J, Nasir M, Couloures K, Sanacora G, Bloch M. Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial FOCUS The Journal Of Lifelong Learning In Psychiatry 2021, 20: 241-251. DOI: 10.1176/appi.focus.22020004.
- Holmes S, Scheinost D, Finnema S, Naganawa M, Davis M, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Pietrzak R, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. 142. Synaptic Density Alterations are Associated With Depression Severity and Network Alterations Biological Psychiatry 2019, 85: s59. DOI: 10.1016/j.biopsych.2019.03.156.
- Webler R, Wilkinson S, Kirwin D, Bloch M, Kitay B, Sanacora G. S128. Expectancy and Ketamine’s Rapid Antidepressant Effect: A Meta-Analysis Biological Psychiatry 2019, 85: s346. DOI: 10.1016/j.biopsych.2019.03.879.
- Krystal A, Pizzagalli D, Smoski M, Mathew S, Nurnberger J, Lisanby S, Iosifescu D, Murrough J, Weiner R, Calabrese J, Sanacora G, Keefe R, Song A, Goodman W, Szabo S, Whitten A, Gao K, Potter W. 116. Results of the NIMH FAST-MAS Phase IIa Proof of Mechanism Study of the Effects of the Selective κ Opioid Antagonist JNJ-67953964 on fMRI Ventral Striatal Activity in Anhedonic Patients Biological Psychiatry 2019, 85: s48-s49. DOI: 10.1016/j.biopsych.2019.03.130.
- Ochs-Ross R, Daly E, Zhang Y, Lane R, Lim P, Foster K, Hough D, Manji H, Drevets W, Sanacora G, Adler C, McShane R, Gaillard R, Singh J. POST HOC ANALYSES OF ESKETAMINE NASAL SPRAY PLUS AN ORAL ANTIDEPRESSANT IN ELDERLY PATIENTS WITH TREATMENT-RESISTANT DEPRESSION American Journal Of Geriatric Psychiatry 2019, 27: s140-s141. DOI: 10.1016/j.jagp.2019.01.094.
- Ochs-Ross R, Daly E, Zhang Y, Lane R, Lim P, Foster K, Hough D, Manji H, Drevets W, Sanacora G, Adler C, McShane R, Gaillard R, Singh J. EFFICACY AND SAFETY OF ESKETAMINE NASAL SPRAY PLUS AN ORAL ANTIDEPRESSANT IN ELDERLY PATIENTS WITH TREATMENT-RESISTANT DEPRESSION American Journal Of Geriatric Psychiatry 2019, 27: s139-s140. DOI: 10.1016/j.jagp.2019.01.093.
- Sanacora G, Kitay B, Wilkinson S. Chapter 35 The Search for Rapid Acting Antidepressants: Research Synthesis and Perspectives 2019, 401-413. DOI: 10.1016/b978-0-12-813333-0.00035-4.
- Wajs E, Leah A, Morrison R, Daly E, Lane R, Lim P, Holder R, Sanacora G, Young A, Kasper S, Sulaiman A, Li C, Paik J, Manji H, Hough D, Drevets W, Singh J. Long-term safety of esketamine nasal spray plus oral antidepressant in patients with treatment-resistant depression: SUSTAIN-2 phase 3 study European Neuropsychopharmacology 2019, 29: s44-s45. DOI: 10.1016/j.euroneuro.2018.11.1016.
- Ochs-Ross R, Daly E, Zhang Y, Lane R, Lim P, Foster K, Hough D, Manji H, Drevets W, Sanacora G, Adler C, McShane R, Gaillard R, Singh J. Efficacy and safety of esketamine nasal spray plus an oral antidepressant in elderly patients with treatment-resistant depression European Neuropsychopharmacology 2019, 29: s355-s356. DOI: 10.1016/j.euroneuro.2018.11.548.
- Wajs E, Aluisio L, Morrison R, Daly E, Lane R, Lim P, Holder R, Sanacora G, Young A, Kasper S, Sulaiman A, Li C, Paik J, Manji H, Hough D, Drevets W, Singh J. Etude de phase 3 en ouvert évaluant l’efficacité et la sécurité d’emploi à long terme d’Eskétamine intranasal (ESK IN) associé à un antidépresseur oral chez des patients atteints de dépression résistante (SUSTAIN-2) French Journal Of Psychiatry 2018, 1: s176. DOI: 10.1016/s2590-2415(19)30445-3.
- Holmes S, Finnema S, Davis M, DellaGioia N, Naganawa M, Nabulsi N, Matuskey D, Pietrzak R, Duman R, Sanacora G, Carson R, Esterlis I. F149. Preliminary Evidence for Altered Synaptic Density and a Possible Role for Accelerated Ageing in Individuals With MDD as Measured With [11C]UCB-J PET Biological Psychiatry 2018, 83: s296. DOI: 10.1016/j.biopsych.2018.02.763.
- Wilkinson S, Webler R, Katz R, Toprak M, Ostroff R, Sanacora G. S106. Acute and Longer-Term Outcomes Using Ketamine as a Clinical Treatment at the Yale Psychiatric Hospital Biological Psychiatry 2018, 83: s388. DOI: 10.1016/j.biopsych.2018.02.997.
- Ochs-Ross R, Daly E, Zhang Y, Lane R, Lim P, Foster K, Hough D, Manji H, Drevets W, Sanacora G, Adler C, McShane R, Gaillard R, Singh J. S114. Efficacy and Safety of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Patients With Treatment-Resistant Depression Biological Psychiatry 2018, 83: s391. DOI: 10.1016/j.biopsych.2018.02.1005.
- Sanacora G, Chowdhury G, Rothman D, Behar K. 662 Ketamine and Rapastinel Effects on Glutamate Cycling Biological Psychiatry 2017, 81: s268. DOI: 10.1016/j.biopsych.2017.02.1071.
- Dwyer J, Sanacora G, Bloch M. 1002 Ketamine as a Treatment for Adolescent Major Depressive Disorder Biological Psychiatry 2017, 81: s405. DOI: 10.1016/j.biopsych.2017.02.729.
- Sanacora G, Wilkinson S, Van Schalkwyk G. 201 Measuring Dissociative Effects of NMDA Receptor Antagonists in the Treatment of Depression Biological Psychiatry 2017, 81: s83. DOI: 10.1016/j.biopsych.2017.02.214.
- Ostroff R, Wilkinson S, Sanacora G. Computer-assisted cognitive behavior therapy to prevent relapse following electroconvulsive therapy Brain Stimulation 2017, 10: 524. DOI: 10.1016/j.brs.2017.01.529.
- Hermes G, Sanacora G. Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies 2016, 73-98. DOI: 10.1007/978-3-319-42925-0_6.
- Sanacora G, Heimer H, Hartman D, Mathew S, Frye M, Nemeroff C, Robinson Beale R. Balancing the Promise and Risks of Ketamine Treatment for Mood Disorders Neuropsychopharmacology 2016, 42: 1179-1181. PMID: 27640324, PMCID: PMC5437876, DOI: 10.1038/npp.2016.193.
- Krystal J, Sanacora G, Abdallah C, Duman R. Speaker 4: John Krystal, USA The International Journal Of Neuropsychopharmacology 2016, 19: 19-19. PMCID: PMC5616528, DOI: 10.1093/ijnp/pyw042.052.
- Singh J, Fedgchin M, Daly E, De Boer P, Cooper K, Lim P, Pinter C, Murrough J, Sanacora G, Shelton R, Kurian B, Winokur A, Fava M, Manji H, Drevets W, Van Nueten L. P.2.b.017 Onset of efficacy of ketamine in treatment-resistant depression: a double-blind, randomised, placebo-controlled, dose frequency study European Neuropsychopharmacology 2014, 24: s387-s388. DOI: 10.1016/s0924-977x(14)70618-2.
- Kiselycznyk C, Sanacora G. Using Our Understanding of Stress-Related Effects on Glutamate Neurotransmission to Guide the Development of Novel Treatment Strategies 2014, 313-341. DOI: 10.1007/978-1-4939-1056-4_17.
- Sanacora G, Duman R. The Revolution in Rapid-Acting Antidepressants Biological Psychiatry 2013, 73: 1123-1124. DOI: 10.1016/j.biopsych.2013.04.020.
- Abdallah CG, Fasula M, Kelmendi B, Sanacora G, Ostroff R. Rapid Antidepressant Effect of Ketamine in the Electroconvulsive Therapy Setting Journal Of Ect 2012, 28: 157-161. PMID: 22847373, PMCID: PMC3426617, DOI: 10.1097/yct.0b013e31824f8296.
- Laje G, Lally N, Mathews D, Brutsche N, Chemerinski A, Akula N, Kelmendi B, Simen A, McMahon FJ, Sanacora G, Zarate C. Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Antidepressant Efficacy of Ketamine in Depressed Patients Biological Psychiatry 2012, 72: e27-e28. PMID: 22771240, PMCID: PMC3786174, DOI: 10.1016/j.biopsych.2012.05.031.
- Morgan PT, Pace-Schott EF, Mason GF, Forselius E, Fasula M, Valentine GW, Sanacora G. Cortical GABA Levels in Primary Insomnia Sleep 2012, 35: 807-814. PMID: 22654200, PMCID: PMC3353043, DOI: 10.5665/sleep.1880.
- Chowdhury GM, Behar KL, Cho W, Thomas MA, Rothman DL, Sanacora G. 1H-[13C]-Nuclear Magnetic Resonance Spectroscopy Measures of Ketamine's Effect on Amino Acid Neurotransmitter Metabolism Biological Psychiatry 2011, 71: 1022-1025. PMID: 22169441, PMCID: PMC3660962, DOI: 10.1016/j.biopsych.2011.11.006.
- Popoli M, Yan Z, McEwen BS, Sanacora G. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission Nature Reviews Neuroscience 2011, 13: 22-37. PMID: 22127301, PMCID: PMC3645314, DOI: 10.1038/nrn3138.
- Larkin G, Beautrais A, Turelli R, Sanacora G, Powsner S, Lippmann M, Krystal J. P03-437 - A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department European Psychiatry 2011, 26: 1607. DOI: 10.1016/s0924-9338(11)73311-9.
- Valentine GW, Mason GF, Gomez R, Fasula M, Watzl J, Pittman B, Krystal JH, Sanacora G. The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [1H]-MRS Psychiatry Research 2011, 191: 122-127. PMID: 21232924, PMCID: PMC3061550, DOI: 10.1016/j.pscychresns.2010.10.009.
- Larkin G, Beautrais A, Powsner S, Sanacora G, Krystal J, Turelli R, Lippmann M. 157: A Prospective Open Label Trial of Low Dose Ketamine for Acute Suicidal States In the Emergency Department Annals Of Emergency Medicine 2010, 56: s53. DOI: 10.1016/j.annemergmed.2010.06.204.
- Sanacora G, Banasr M, Chowdhury G, Lepak A, Behar K. S.28.05 Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioural deficits by the glutamate-modulating drug riluzole European Neuropsychopharmacology 2010, 20: s208. DOI: 10.1016/s0924-977x(10)70241-8.
- Saricicek A, Maloney K, Lorberg B, Muralidharan A, Ruf B, Blumberg H, Hu J, Pittman B, Sanacora G, Bhagwagar Z. P.2.e.029 Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo controlled trial European Neuropsychopharmacology 2009, 19: s465. DOI: 10.1016/s0924-977x(09)70728-x.
- Banasr M, Chowdhury GM, Terwilliger R, Newton SS, Duman RS, Behar KL, Sanacora G. Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole Molecular Psychiatry 2008, 15: 501-511. PMID: 18825147, PMCID: PMC3347761, DOI: 10.1038/mp.2008.106.
- Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders Nature Reviews Drug Discovery 2008, 7: 426-437. PMID: 18425072, PMCID: PMC2715836, DOI: 10.1038/nrd2462.
- Neumeister A, Charney D, Sanacora G, Krystal J. Neurobiology and Treatment of Depression 2007 DOI: 10.1002/9780470101001.hcn018.
- Sanacora G. Evidence for GABAergic and Glutamatergic Involvement in the Pathophysiology and Treatment of Depressive Disorders 2002, 739-749. DOI: 10.1002/0470854871.chxviii3.
- Krystal J, D'Souza D, Sanacora G, Goddard A, Charney D. CURRENT PERSPECTIVES ON THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA, DEPRESSION, AND ANXIETY DISORDERS Medical Clinics Of North America 2001, 85: 559-577. PMID: 11349473, DOI: 10.1016/s0025-7125(05)70329-1.
- Chen A, Shin K, Duman R, Sanacora G. ECS-Induced Mossy Fiber Sprouting and BDNF Expression Are Attenuated By Ketamine Pretreatment Journal Of Ect 2001, 17: 27-32. PMID: 11281511, DOI: 10.1097/00124509-200103000-00006.
- Berman R, Sanacora G, Narasimhan M, Oren D, Cappiello A, Charney D. 268. Simultaneous catecholamine and indoleamine depletion in unmedicated depressed subjects Biological Psychiatry 2000, 47: s81. DOI: 10.1016/s0006-3223(00)00532-1.
- Mason G, Sanacora G, Anand A, Epperson C, Goddard A, Rothman D, Charney D, Krystal J. 304. Cortical GABA reduced in unipolar but not bipolar depression Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00568-0.
- Sanacora G, Mason G, Rothman D, Epperson C, Goddard A, Krystal J. 305. Reduced cortical GABA in depression is not due to decreased gray matter Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00569-2.
- Berman R, Narasimhan M, Sanacora G, Miano A, Hoffman R, Hu X, Charney D, Boutros N. A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression Biological Psychiatry 2000, 47: 332-337. PMID: 10686268, DOI: 10.1016/s0006-3223(99)00243-7.
- Sanacora G, Mason G, Krystal J. Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies Critical Reviews In Neurobiology 2000, 14: 23. PMID: 11253954, DOI: 10.1615/critrevneurobiol.v14.i1.20.
- Sanacora G, Rothman D, Krystal J. Applications of Magnetic Resonance Spectroscopy to Psychiatry The Neuroscientist 1999, 5: 192-196. DOI: 10.1177/107385849900500316.
- Sanacora G, Mason G, Rothman D, Berman R, Charney D, Ciarcia J, Krystal J. 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS Journal Of Ect 1999, 15: 102. DOI: 10.1097/00124509-199903000-00009.
- Sanacora G, Chen A, Shin K, Duman R. 8. Ketamine Effects on ECS Induced BDNF Expression and Mossy Fiber Sprouting Journal Of Ect 1999, 15: 109. DOI: 10.1097/00124509-199903000-00028.
- Malison R, Price L, Berman R, van Dyck C, Pelton G, Carpenter L, Sanacora G, Owens M, Nemeroff C, Rajeevan N, Baldwin R, Seibyl J, Innis R, Charney D. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography Biological Psychiatry 1998, 44: 1090-1098. PMID: 9836013, DOI: 10.1016/s0006-3223(98)00272-8.
- Sanacora G, Goddard A, Gil R, D'Souza D, Abi-Saab W, Petroff O, Mattson R, Mason G, Behar K, Ciarcia J, Berman R, Charney D, Rothman D, Krystal J. 24. Quantification of cortical GABA levels in neuropsychiatric patients Biological Psychiatry 1998, 43: s8. DOI: 10.1016/s0006-3223(98)90472-3.
- Berman R, Boutros N, Narasimhan M, Sanacora G, Charney D. 322. Transcranial magnetic stimulation in treatment-refractory depression Biological Psychiatry 1998, 43: s97. DOI: 10.1016/s0006-3223(98)90770-3.
Patient Care Organizations
1
Clinical Neuroscience Research Unit
Connecticut Mental Health Center
34 Park Street
New Haven, CT 06519
1 of 3
- Clinical Neuroscience Research UnitConnecticut Mental Health Center34 Park StreetNew Haven, CT 06519
- Yale Depression Research Clinic100 York StreetSte 2JNew Haven, CT 06511
- Interventional PsychiataryYale New Haven Hospital - West Pavilion1 Park StreetNew Haven, CT 06504