Winchester Center for Lung Disease

Fitkin Memorial Pavilion

789 Howard Avenue, Ste 2nd floor

New Haven, CT 06519

1-203-495-2410

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Winchester Center for Lung Disease
Fitkin Memorial Pavilion
789 Howard Avenue, Ste 2nd floor
New Haven, CT 06519
- 1-203-495-2410
- Directions
Winchester Center for Lung Disease
North Haven Medical Center
6 Devine Street
North Haven, CT 06473
- 1-203-495-2410
- Directions

View Academic Profile

Click here to view more about this specialist's research and educational efforts on https://medicine.yale.edu

Click here to view more about this specialist's research and educational efforts onhttps://medicine.yale.edu

Geoffrey Chupp, MD

Pulmonology & Sleep Medicine, Asthma , Pulmonary Critical Care

Telehealth is available

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Patient type treated

Adult

Accepting new patients

Yes

Referral required

From patients or physicians

Insurance accepted

View Academic Profile

Click here to view more about this specialist's research and educational efforts on https://medicine.yale.edu

Click here to view more about this specialist's research and educational efforts onhttps://medicine.yale.edu

Biography

Geoffrey Chupp, MD, is a pulmonologist who specializes in lung diseases that affect the airway, including severe asthma, Chronic Obstructive Pulmonary Disease (COPD), bronchiolitis, autoimmune airway diseases, and airway diseases that have not been classified. He also specializes in eosinophilic lung diseases such as eosinophilic pneumonia, eosinophilic granulomatosis with polyangiitis (EGPA), and Allergic Bronchopulmonary Aspergillosis (ABPA).

He often helps patients who have complex disease that has been difficult to treat.

“I wanted to pursue a career in medicine to comfort people who are sick and discover the cause or causes of their disease,” says Dr. Chupp. Working with pulmonary patients is especially rewarding for a doctor, he adds. “It crosses all segments of society, so I get to meet lots of interesting people.”

Dr. Chupp came to Yale in 1997 and developed the Yale Center for Asthma & Airways Disease (YCAAD), a multidisciplinary clinical program that he still directs. The center cares for a broad spectrum of conditions and has helped patients with conditions that are difficult to diagnose, sometimes because of a co-occurring illness such as gastroesophageal reflux or sinusitis, and provides treatments that may not be available elsewhere. “We have novel biologic treatments and access to clinical trials for these patients,” he says.

Up to 20 clinical trials are active at any given time at YCAAD. This research has helped put Yale Medicine on the cutting edge of individualized asthma therapy and precision medicine for patients with asthma. “We see a future where we will be identifying a patient’s particular genetic risk factors and the molecular signals that are driving their particular disease,” says Dr. Chupp. “We will develop a combination of treatments that is personalized for every patient; it will include lifestyle recommendations, inhaled therapies, and biologic therapies that will maximally manage their disease without guesswork.”

Titles

Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine )
Director, Yale Center for Asthma and Airways Disease (YCAAD), Pulmonary, Critical Care & Sleep Medicine
Director, Pulmonary Function Laboratory, Yale New Haven Hospital, Pulmonary, Critical Care & Sleep Medicine

Education & Training

MA
Yale University, Privatim (2017)
Fellow
Boston University School of Medicine (1997)
Resident
Tufts University/New England Medical Center (1993)
Intern
Tufts-New England Medical Center (1991)
MD
George Washington University (1990)
BS
Tufts University (1986)

Additional Information

Honors & Recognitions

Publications

PrecISE- A Biomarker Stratified Adaptive Trial of 5 Interventions in Severe Asthma: Final Protocol and the Baseline Cohort
Denlinger L, Israel E, Moore W, Georas S, Wright R, Castro M, Peden D, Anstrom K, Bleecker E, Alexander L, Cahill K, Cardet J, Carr T, Cedano J, Chen A, Chupp G, Comhair S, DiMango E, Erzurum S, Fahy J, Fajt M, Gaston B, Jackson D, Jain S, Jarjour N, Kenyon N, Kraft M, Krishnan J, Kumar R, Lugogo N, Martinez F, Marquis M, Pappalardo A, Phipatanakul W, Rank M, Rosenberg S, Salciccioli J, Sanchez M, Smith L, Sumino K, Szefler S, Tang M, Vijayanand P, Wechsler M, Wenzel S, White S, Zeki A, Ivanova A, Bacharier L, Akuthota P, Team N, Bleecker E, Carr T, Moore W, Rank M, Camacho G, Gerald L, Hastie A, Krings J, Martinez F, Merchen J, Meyers D, Nirendran N, Ortega V, Pippins A, Rusk A, Schunk R, Skeps R, Simmons T, Williamson P, Zein J, Israel E, Cardet J, DiMango E, Phipatanakul W, Bailey J, Banzon T, Bartnikas L, Baxi S, Betapudi V, Brick I, Casale T, Cinelli M, Crestani E, Cunningham A, Esty B, Fandozzi ;, Fernandez J, Fitzpatrick E, Flam B, Forth V, Gaffin J, Gentile K, Gueye-Ndiaye S, Haley K, Heromin R, Hauptmann M, Kaage T, Kelly M, Kraemer M, LaBere B, Lai P, Le M, Ledford D, Lee J, Lee J, Lockey R, Macginnitie A, McCarty K, Moss K, Mukharesh L, Pistenmaa A, Pepper A, Pimental M, Queheillalt D, Robinson A, Salciccioli J, Saroya T, Smith C, Trevedi M, Trippa L, Tulchinsky A, Vitiello A, Yee C, Zakar K, White T, Kumar R, Moy J, Rosenberg S, Aalemansour H, Buechler K, Carter T, Fu J, Hixon J, Jackson C, Ji Y, Johnson C, Kalhan R, Kane J, Kaur O, Li G, Lippner E, Makhija M, Maleckar S, Naureckas E, Nyenhuis S, Peters A, Press V, Qureshi M, Ryba D, Sheng J, Smith L, Xu B, Wechsler M, Szefler S, Chupp G, Holguin F, Kraft M, Liu A, Rogers L, Anderson D, Belimezova S, Bitzan J, Bose S, Brock J, Sanchez J, Clark B, Cohn L, Cotarian A, Cruse M, Eisenberg E, Estrom J, Glassmeyer I, Villalobos J, Grant N, Gruberg B, Guntur V, Hay O, Hills A, Hsieh J, Kessler J, Kolakowski C, Miyazawa N, Pak J, Pruitt D, Rhoads S, Sharma S, Stevens A, Tippin B, Valente C, Vicencio A, Wainscoat C, Weber J, Wessels G, White M, Winnica D, Zeitlin P, Denlinger L, Jarjour N, Krishnan J, Agnihotri N, Bach J, Bires N, DeLisa J, Fichtinger P, Floerke H, Fritz B, Grogan J, Guadarrama A, Hasse W, Jackson D, Kaspari R, Kelley R, Klaus D, Lowell P, Larson L, Norwick L, O’Brien M, Palas T, Pappalardo A, Read E, Schraml A, Schiebler M, Sorkness R, Tattersall M, Wollet L, Gaston B, Erzurum S, Teague W, Chmiel J, Ross K, Aronica M, Beck B, Bendy L, Borish L, Chedraoui C, Comhair S, Davis M, Dix A, Fakhry B, Gammell R, Gluvna A, Hamm E, Heskett M, Hu B, Khatri S, Kirwan J, Kloepfer K, Koo M, Labadia M, Marko A, Matheis N, Mey J, Mulya A, Murphy D, Owensby R, Parker L, Pennington E, Roesch E, Sharp J, Smith C, Solanki N, Veri L, Shifflett K, Yang F, Wenzel S, Lugogo N, Bagheri A, Cislo L, Fajt M, Gauthier M, Hadden M, James P, Mohan A, Moore J, Nouraie S, Ramonell R, Romanek R, Sullivan L, Trudeau J, Zhang M, Akuthota P, Jain S, Vijayanand P, Barry J, Beg N, Brickner H, Alexander L, Diaz D, Jafari Y, McKeon N, Fahy J, Kenyon N, Almario M, Charbit A, Cho L, Gale B, Haczku A, Harper R, Houston T, Kain C, Kivler C, Kuhn B, Liu M, McCourt P, Miller J, Nguyen A, Orain X, Peters M, Plough A, Ramirez K, Rossi L, Schivo M, Singapuri M, Teuber S, Tham T, Tompkins D, Vi J, Zeki A, Castro M, Bacharier L, Sumino K, Atha J, Boomer J, Cahill K, Clover A, Dorman V, Hoffman E, Jackson F, Klinck M, Krings J, Madison J, Quigley J, Quinones T, Saxena S, Sharpe M, Troyer J, Yen-Declue H, Zulich A, Ivanova A, Anstrom K, LaVange L, Bagaason S, Britt A, Bryan H, Burbank A, Chen A, Culpepper C, DeMarcus F, Fenu C, Gotman N, Green R, Harrison L, James J, Kosorok J, Kosorok M, Littleton L, Marquis M, O'Neal W, Peden D, Price R, Quibrera P, Ritz C, Sanchez M, Schwartz S, Slye N, Song T, Wilson N, Croxton T, Lu J, Noel P, Bamdad J, Georas S, Wright R. PrecISE- A Biomarker Stratified Adaptive Trial of 5 Interventions in Severe Asthma: Final Protocol and the Baseline Cohort. The Journal Of Allergy And Clinical Immunology 2026 PMID: 41707916, DOI: 10.1016/j.jaci.2026.02.001.
Switching to twice-yearly depemokimab from mepolizumab/benralizumab in severe asthma: A multicenter, randomized, double-blind, Phase 3A Clinical Trial (NIMBLE).
Chupp G, Nagase H, Skowasch D, Devouassoux G, Côté A, Jackson D, Jackson D, Wechsler M, Imber V, McGinniss J, K S, Howarth P, Pavord I. Switching to twice-yearly depemokimab from mepolizumab/benralizumab in severe asthma: A multicenter, randomized, double-blind, Phase 3A Clinical Trial (NIMBLE). American Journal Of Respiratory And Critical Care Medicine 2026 PMID: 41738176, DOI: 10.1093/ajrccm/aamag031.
Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma.
Kay S, Rajeevan H, Son M, Kwah J, Ramirez M, Liu Y, Wang Z, Yan X, Nino G, Britto C, Chupp G, Gomez J. Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma. American Journal Of Respiratory Cell And Molecular Biology 2025, 73: 884-896. PMID: 40587876, DOI: 10.1165/rcmb.2024-0565oc.
Mepolizumab in patients with severe asthma and blood eosinophil counts between 150 and 300 cells per µL: benefits at two years
Canonica G, Bagnasco D, Lee J, Chupp G, Schleich F, Oppenheimer J, Zhang L, Alfonso-Cristancho R, Howarth P. Mepolizumab in patients with severe asthma and blood eosinophil counts between 150 and 300 cells per µL: benefits at two years. ERJ Open Research 2025, 11: 01390-2024. PMID: 41220814, PMCID: PMC12598589, DOI: 10.1183/23120541.01390-2024.
Impact of Demographics on Mepolizumab Effectiveness in Severe Asthma: One-Year REALITI-A Subanalysis
Chupp G, Heaney L, Pelaia G, Almonacid C, Maxwell A, Zhang L, Alfonso-Cristancho R, Howarth P, Brusselle G. Impact of Demographics on Mepolizumab Effectiveness in Severe Asthma: One-Year REALITI-A Subanalysis. The Journal Of Allergy And Clinical Immunology In Practice 2025, 13: 3286-3295. PMID: 40780384, DOI: 10.1016/j.jaip.2025.07.049.
Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma
Caruso C, Canonica G, Patel M, Smith A, Liu M, Alfonso-Cristancho R, Price R, Jakes R, Demetriou L, Valero A, Köhler T, Pilette C, Chupp G, Brusselle G, Howarth P. Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma. CHEST Pulmonary 2025, 3: 100107. DOI: 10.1016/j.chpulm.2024.100107.
Maintenance of an Asthma Intervention Post-Trial: Use of a Patient-Activated Reliever-Triggered Inhaled Corticosteroid (PARTICS) Strategy in Black and Latinx Patients
Cardet J, Bailey J, Hurley L, Maher N, Staton E, Yawn B, Zaeh S, Israel E, investigators; O, Apter A, Bradford P, Calderon-Candelario R, Carroll J, Chupp G, Cohen R, Ericson B, Fuhlbrigge A, Kaplan B, Kruse J, Nazario S, Pace W, Pasarica M, Phipatanakul W, Riley I, Rodriguez-Louis J, Shenoy K, Stranges P, Tapp H, Wechsler M. Maintenance of an Asthma Intervention Post-Trial: Use of a Patient-Activated Reliever-Triggered Inhaled Corticosteroid (PARTICS) Strategy in Black and Latinx Patients. The Journal Of The American Board Of Family Medicine 2025, 38: 378-382. PMID: 40578913, PMCID: PMC12616832, DOI: 10.3122/jabfm.2024.240014r2.
The next frontier Defining and optimizing treatments for patients with type 2 low asthma
Zidan E, Wilson G, Shin J, Chupp G. The next frontier Defining and optimizing treatments for patients with type 2 low asthma. Annals Of Allergy Asthma & Immunology 2024, 134: 3-4. PMID: 39414022, DOI: 10.1016/j.anai.2024.10.013.
Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils
Buchheit K, Shaw D, Chupp G, Lehtimaki L, Heffler E, Finney‐Hayward T, Zangrilli J, Kwiatek J, Siddiqui S, Roufosse F, Thamboo A, West N, Vichiendilokkul A, Hellings P, Peters A, Howarth P. Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils. Allergy 2024, 79: 2662-2679. PMID: 39359069, DOI: 10.1111/all.16303.
Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma
Wilson G, Gautam S, Chupp G. Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma. Biomedicines 2024, 12: 2011. PMID: 39335525, PMCID: PMC11428232, DOI: 10.3390/biomedicines12092011.
Adoption and implementation of maintenance and reliever therapy for adults with moderate-to-severe asthma
Zaeh S, Zimmerman Z, Eakin M, Chupp G. Adoption and implementation of maintenance and reliever therapy for adults with moderate-to-severe asthma. Annals Of Allergy Asthma & Immunology 2024, 133: 318-324. PMID: 38897404, PMCID: PMC11344662, DOI: 10.1016/j.anai.2024.06.011.
Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma Across Multiple Clinically Relevant Subgroups in the NAVIGATOR Study
Carr T, Moore W, Kraft M, Brusselle G, Castro M, Chupp G, Wechsler M, Hunter G, Lindsley A, Llanos J, Burke L, Chandarana S, Ambrose C. Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma Across Multiple Clinically Relevant Subgroups in the NAVIGATOR Study. Advances In Therapy 2024, 41: 2978-2990. PMID: 38802635, PMCID: PMC11213736, DOI: 10.1007/s12325-024-02889-8.
Asthma control in the United States Relationships between short-acting β2-agonist and systemic corticosteroid use
Chupp G, Murphy K, Gandhi H, Gilbert I, Bleecker E. Asthma control in the United States Relationships between short-acting β2-agonist and systemic corticosteroid use. Annals Of Allergy Asthma & Immunology 2024, 133: 302-309. PMID: 38740134, DOI: 10.1016/j.anai.2024.05.003.
MELTEMI and COLUMBA: 5-Year Comparative Safety Analysis of Benralizumab and Mepolizumab
Bourdin A, Chupp G, Jackson D, Cohen D, Emerath U, Shavit A, Kurdyukova Y, Menzies-Gow A. MELTEMI and COLUMBA: 5-Year Comparative Safety Analysis of Benralizumab and Mepolizumab. The Journal Of Allergy And Clinical Immunology In Practice 2024, 12: 2074-2083.e4. PMID: 38677588, DOI: 10.1016/j.jaip.2024.04.033.
Activated sputum eosinophils associated with exacerbations in children on mepolizumab
Wilson G, Knight J, Liu Q, Shelar A, Stewart E, Wang X, Yan X, Sanders J, Visness C, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Activated sputum eosinophils associated with exacerbations in children on mepolizumab. The Journal Of Allergy And Clinical Immunology 2024, 154: 297-307.e13. PMID: 38485057, PMCID: PMC11305967, DOI: 10.1016/j.jaci.2024.01.031.
Targeting Asthma Remission as the Next Therapeutic Step Toward Improving Disease Control
Busse W, Chupp G, Corbridge T, Stach-Klysh A, Oppenheimer J. Targeting Asthma Remission as the Next Therapeutic Step Toward Improving Disease Control. The Journal Of Allergy And Clinical Immunology In Practice 2024, 12: 894-903. PMID: 38320720, DOI: 10.1016/j.jaip.2024.01.044.
Implementing Antiinflammatory Reliever Strategies in Asthma The Evolving Paradigm of Asthma Management
Zaeh S, Eakin M, Chupp G. Implementing Antiinflammatory Reliever Strategies in Asthma The Evolving Paradigm of Asthma Management. Chest 2024, 165: 250-252. PMID: 38336438, DOI: 10.1016/j.chest.2023.09.004.
Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma
Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.
Correction: iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects
Liu Y, Zhao J, Adams T, Wang N, Schupp J, Wu W, McDonough J, Chupp G, Kaminski N, Wang Z, Yan X. Correction: iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects. BMC Bioinformatics 2023, 24: 394. PMID: 37858060, PMCID: PMC10588114, DOI: 10.1186/s12859-023-05523-6.
iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects
Liu Y, Zhao J, Adams T, Wang N, Schupp J, Wu W, McDonough J, Chupp G, Kaminski N, Wang Z, Yan X. iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects. BMC Bioinformatics 2023, 24: 318. PMID: 37608264, PMCID: PMC10463720, DOI: 10.1186/s12859-023-05432-8.
Mepolizumab Reduces Systemic Corticosteroid Use in Chronic Rhinosinusitis With Nasal Polyps
Chupp G, Alobid I, Lugogo N, Kariyawasam H, Bourdin A, Chaker A, Smith S, Sousa A, Mayer B, Chan R, Matucci A. Mepolizumab Reduces Systemic Corticosteroid Use in Chronic Rhinosinusitis With Nasal Polyps. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3504-3512.e2. PMID: 37586475, DOI: 10.1016/j.jaip.2023.08.015.
Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19
Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.
Is there a best strategy to prevent asthma exacerbations in inner-city patients with asthma?
Zaeh S, Chupp G, Eakin M. Is there a best strategy to prevent asthma exacerbations in inner-city patients with asthma? Annals Of Allergy Asthma & Immunology 2023, 132: 11-12. PMID: 37433383, PMCID: PMC10774450, DOI: 10.1016/j.anai.2023.07.003.
Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials
Corren J, Menzies-Gow A, Chupp G, Israel E, Korn S, Cook B, Ambrose C, Hellqvist Å, Roseti S, Molfino N, Llanos J, Martin N, Bowen K, Griffiths J, Parnes J, Colice G. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 13-24. PMID: 37015033, PMCID: PMC10870853, DOI: 10.1164/rccm.202210-2005oc.
Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study
Menzies-Gow A, Bourdin A, Chupp G, Israel E, Hellqvist Å, Hunter G, Roseti S, Ambrose C, Llanos J, Cook B, Corren J, Colice G. Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study. Annals Of Allergy Asthma & Immunology 2023, 131: 343-348.e2. PMID: 37263380, DOI: 10.1016/j.anai.2023.05.028.
Dupilumab improves long‐term outcomes in patients with uncontrolled, moderate‐to‐severe GINA‐based type 2 asthma, irrespective of allergic status
Rabe K, Pavord I, Busse W, Chupp G, Izuhara K, Altincatal A, Gall R, Pandit‐Abid N, Deniz Y, Rowe P, Jacob‐Nara J, Radwan A. Dupilumab improves long‐term outcomes in patients with uncontrolled, moderate‐to‐severe GINA‐based type 2 asthma, irrespective of allergic status. Allergy 2023, 78: 2148-2156. PMID: 37073882, DOI: 10.1111/all.15747.
Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study
Pavord I, Gardiner F, Heaney L, Domingo C, Price R, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P. Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study. Frontiers In Immunology 2023, 14: 1150162. PMID: 37122713, PMCID: PMC10131245, DOI: 10.3389/fimmu.2023.1150162.
Efficacy and safety of tezepelumab in patients with uncontrolled disease while receiving maintenance therapy for moderate or severe asthma
Corren J, Wechsler M, Chupp G, Roseti S, Hellqvist Å, Martin N, Llanos J, Ambrose C, Colice G. Efficacy and safety of tezepelumab in patients with uncontrolled disease while receiving maintenance therapy for moderate or severe asthma. The Journal Of Allergy And Clinical Immunology In Practice 2022, 11: 943-945.e2. PMID: 36375743, DOI: 10.1016/j.jaip.2022.10.042.
Asthma exacerbations during the pandemic: Time to rethink clinical markers
Ortega H, Katz L, Chupp G. Asthma exacerbations during the pandemic: Time to rethink clinical markers. Journal Of Allergy And Clinical Immunology Global 2022, 2: 97-100. PMID: 36281240, PMCID: PMC9581642, DOI: 10.1016/j.jacig.2022.09.003.
Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults
Shlipak M, Sheshadri A, Hsu F, Chen S, Jotwani V, Tranah G, Fielding R, Liu C, Ix J, Coca S, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Leeuwenburgh J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Beard V, Tsiroyannis E, Hau C, Manini T, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rushing J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Sweeney Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Hankinson J, Vaz Fragoso C, Groessl E, Kaplan R. Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults. JAMA Internal Medicine 2022, 182: 650-659. PMID: 35499834, PMCID: PMC9062767, DOI: 10.1001/jamainternmed.2022.1449.
Mepolizumab Reduces Hypereosinophilic Syndrome Flares Irrespective of Blood Eosinophil Count and Interleukin-5
Rothenberg M, Roufosse F, Faguer S, Gleich G, Steinfeld J, Yancey S, Mavropoulou E, Kwon N, Group H, García G, Sosso A, Wehbe L, Yañez A, Blockmans D, Roufosse F, Antila M, Blanco D, Grava S, Lima M, Pez A, Faguer S, Hamidou M, Kahn J, Lefévre G, Brockow K, Kern P, Reiter A, Walz B, Welte T, Pane F, Vannucchi A, Cerino-Javier R, Gazca-Aguilar A, Hernández-Colín D, Valdéz-López H, Kupryś-Lipińska I, Musial J, Prejzner W, Mihaly E, Popov V, Zdrenghea M, Gritsaev S, Ivanov V, Tsyba N, Alonso A, Xutgla M, Fox M, Delgado R, Rivas J, Santillana G, González A, Wardlaw A, Akuthota P, Butterfield J, Chupp G, Cox J, Gleich G, Jhaveri D, Rothenberg M. Mepolizumab Reduces Hypereosinophilic Syndrome Flares Irrespective of Blood Eosinophil Count and Interleukin-5. The Journal Of Allergy And Clinical Immunology In Practice 2022, 10: 2367-2374.e3. PMID: 35568330, DOI: 10.1016/j.jaip.2022.04.037.
Natural history of disease burden for US patients with asthma vs asthma and COPD
Bleecker E, Murphy K, Gandhi H, Gilbert I, Zein J, Reibman J, Chupp G. Natural history of disease burden for US patients with asthma vs asthma and COPD. 2020, 1397. DOI: 10.1183/13993003.congress-2020.1397.
Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control Measure
Murphy K, Chipps B, Beuther D, Wise R, McCann W, Gilbert I, Eudicone J, Gandhi H, Harding G, Coyne K, Zeiger R, Board P, Kobernick A, Mohammad A, Cherry A, Fein A, Gaines A, Ramsey A, Michaud A, Palmer A, Kim A, Smith A, White A, Ricci A, Kettelhut B, Modena B, Stone B, Rolston B, Schnapf B, Krajicek B, Kraft C, Hopkins C, Natalie C, Anderson C, Czajkowski C, Arce D, Hamlin D, Hill D, Mares D, Pham D, Liao D, Simmons D, Johnson D, Jhaveri D, Maselli D, Kerwin E, Schuman E, Sher E, Bleecker E, Rakowski E, Hsu F, Averill F, Barsanti F, Gross G, Chupp G, Head G, Nasir H, Lee H, Barjaktarevic I, Cook J, Krainson J, Pearl J, Bellak J, Perez-Fernandez J, Rehm J, Trevor J, Most J, Hanson J, Blessing-Moore J, Biller J, Gedell J, Southard J, Chancellor J, Ilowite J, Romeo J, Mercado J, Fisher J, Greiwe J, Gregory K, Nadeau K, Shenoy K, Tan L, Stefanowicz L, Humes L, Bowers L, O’Connor M, Perez M, White M, Hegewald M, Wilson M, Sikora M, Morganroth M, Smith M, Farooqui N, Lesch N, Jain N, Parikh N, Hartog N, Luthin P, Stewart P, O’Connor P, Schochet P, Goldberg P, Patel P, Chinthrajah R, Sidhu R, Ayinla R, Brown R, Stadtler R, Wachs R, Balkissoon R, Duplantier R, Puente R, Settipane R, Mustafa S, Surani S, Jawad S, Adams S, Villegas S, Al-Farra S, Subramanian S, Bains S, Kelsen S, Wise S, Estrella-Eades S, Smith S, Qureshi T, Chen T, Kelbel T, Miller T, Jain V, Soong W, Soler X, Mattar Z. Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control Measure. The Journal Of Allergy And Clinical Immunology In Practice 2020, 8: 2263-2274.e5. PMID: 32387166, DOI: 10.1016/j.jaip.2020.02.042.
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability
Glynn N, Gmelin T, Santanasto A, Lovato L, Lange‐Maia B, Nicklas B, Fielding R, Manini T, Myers V, Rekeneire N, Spring B, Pahor M, King A, Rejeski W, Newman A, Pahor M, Guralnik J, Anton S, Buford T, Leeuwenburgh C, Nayfield S, Manini T, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Joyce K, Lovato L, Pierce J, Roberson W, Robertson J, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Chen S, Pierce J, Chen H, Hadley E, Romashkan S, Patel K, Bethesda, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor‐Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Yank V, Berra K, Bell C, Thiessen R, Youngman K, Virgen S, Maldonado E, Tarin K, Klaftenegger H, Prosak C, Campero I, Garcia D, Soto J, Chio L, Hoskins D, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Krol J, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Nayfield S, Sandesara B, Black M, Burk W, Hoover B, Knaggs J, Marena W, Korytov I, Curtis S, Lorow M, Goswami C, Lewis M, Kamen M, Bitz J, Stanton B, Hicks T, Gay C, Xie C, Morris H, Singletary F, Causer J, Yonce S, Radcliff K, Smith M, Scott J, Rodriguez M, Fitch M, Dunn M, Schllesinger J, Newman A, Studenski S, Goodpaster B, Lopez O, Glynn N, Nadkarni N, Ives D, Newman M, Grove G, Williams K, Bonk J, Rush J, Kost P, Vincent P, Gerger A, Romeo J, Monheim L, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer‐Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, Rekeneire N, McGloin J, Mautner R, Huie‐White S, Bianco L, Zocher J, Wu K, Shepard D, Fennelly B, Castro R, Halpin S, Brennan M, Barnett T, Iannone L, Zenoni M, Bugaj J, Bailey C, Charpentier P, Hawthorne‐Jones G, Mignosa B, Lewis L, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Vaz Fragoso C, Groessl E, Kaplan R. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability. Journal Of The American Geriatrics Society 2019, 68: 619-624. PMID: 31867713, PMCID: PMC8061638, DOI: 10.1111/jgs.16274.
Biomarkers, Targeted Therapies, Biologics, and Bronchial Thermoplasty
Mohan A, Grace J, Mainardi A, Chupp G, Lugogo N. Biomarkers, Targeted Therapies, Biologics, and Bronchial Thermoplasty. Respiratory Medicine 2019, 123-153. DOI: 10.1007/978-3-030-20812-7_8.
Measurement of Chitinase Activity in Biological Samples
Amick A, Liu Q, Gautam S, Chupp G, Dela Cruz C, Sharma L. Measurement of Chitinase Activity in Biological Samples. Journal Of Visualized Experiments 2019 DOI: 10.3791/60159-v.
Rapid onset of effect of benralizumab on morning peak expiratory flow in severe, uncontrolled asthma
Chupp G, Lugogo N, Kline J, Ferguson G, Hirsch I, Goldman M, Zangrilli J, Trudo F. Rapid onset of effect of benralizumab on morning peak expiratory flow in severe, uncontrolled asthma. Annals Of Allergy Asthma & Immunology 2019, 122: 478-485. PMID: 30802500, DOI: 10.1016/j.anai.2019.02.016.
Anti–IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison
Busse W, Chupp G, Nagase H, Albers F, Doyle S, Shen Q, Bratton D, Gunsoy N. Anti–IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison. The Journal Of Allergy And Clinical Immunology 2018, 143: 190-200.e20. PMID: 30205189, DOI: 10.1016/j.jaci.2018.08.031.
Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study
Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Salem W, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. The Journals Of Gerontology Series B 2017, 73: 1501-1513. PMID: 28482106, PMCID: PMC6178963, DOI: 10.1093/geronb/gbx051.
Multiparameter Single Cell Profiling of Airway Inflammatory Cells
Yao Y, Welp T, Liu Q, Niu N, Wang X, Britto CJ, Krishnaswamy S, Chupp G, Montgomery RR. Multiparameter Single Cell Profiling of Airway Inflammatory Cells. Cytometry Part B Clinical Cytometry 2017, 92: 12-20. PMID: 27807928, PMCID: PMC5250532, DOI: 10.1002/cyto.b.21491.
Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients
Silkoff P, Laviolette M, Singh D, FitzGerald J, Kelsen S, Backer V, Porsbjerg C, Girodet P, Berger P, Kline J, Chupp G, Susulic V, Barnathan E, Baribaud F, Loza M, investigators A, Strambu I, Lam S, Eich A, Ludwig-Sengpiel A, Leigh R, Dransfield M, Calhoun W, Hussaini A, Chanez P. Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients. The Journal Of Allergy And Clinical Immunology 2017, 140: 710-719. PMID: 28089872, DOI: 10.1016/j.jaci.2016.11.038.
Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study
Aubertin-Leheudre M, Anton S, Beavers D, Manini T, Fielding R, Newman A, Church T, Kritchevsky S, Conroy D, McDermott M, Botoseneanu A, Hauser M, Pahor M, Gill T, Fragoso C, Fielding R, Hauser M, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler M, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. Journal Of The American Medical Directors Association 2016, 18: 312-319. PMID: 27914851, PMCID: PMC5366275, DOI: 10.1016/j.jamda.2016.10.001.
Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study
Layne AS, Hsu FC, Blair SN, Chen SH, Dungan J, Fielding RA, Glynn NW, Hajduk AM, King AC, Manini TM, Marsh AP, Pahor M, Pellegrini CA, Buford TW, Investigators L, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study. Archives Of Physical Medicine And Rehabilitation 2016, 98: 11-24.e3. PMID: 27568165, PMCID: PMC5183463, DOI: 10.1016/j.apmr.2016.07.019.
The role of mepolizumab in atopic and nonatopic severe asthma with persistent eosinophilia
Ortega H, Chupp G, Bardin P, Bourdin A, Garcia G, Hartley B, Yancey S, Humbert M. The role of mepolizumab in atopic and nonatopic severe asthma with persistent eosinophilia. European Respiratory Journal 2014, 44: 239-241. PMID: 24659543, DOI: 10.1183/09031936.00220413.
The Lifestyle Interventions and Independence for Elders Study: Design and Methods
Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu FC, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M. The Lifestyle Interventions and Independence for Elders Study: Design and Methods. The Journals Of Gerontology Series A 2011, 66A: 1226-1237. PMID: 21825283, PMCID: PMC3193523, DOI: 10.1093/gerona/glr123.
Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood
Bjornsdottir US, Holgate ST, Reddy PS, Hill AA, McKee CM, Csimma CI, Weaver AA, Legault HM, Small CG, Ramsey RC, Ellis DK, Burke CM, Thompson PJ, Howarth PH, Wardlaw AJ, Bardin PG, Bernstein DI, Irving LB, Chupp GL, Bensch GW, Bensch GW, Stahlman JE, Karetzky M, Baker JW, Miller RL, Goodman BH, Raible DG, Goldman SJ, Miller DK, Ryan JL, Dorner AJ, Immermann FW, O'Toole M. Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood. PLOS ONE 2011, 6: e21902. PMID: 21779351, PMCID: PMC3136489, DOI: 10.1371/journal.pone.0021902.
Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model
Ramaprakash H, Shibata T, Duffy KE, Ismailoglu UB, Bredernitz RM, Moreira AP, Coelho AL, Das AM, Fursov N, Chupp GL, Hogaboam CM. Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model. American Journal Of Pathology 2011, 179: 104-115. PMID: 21640974, PMCID: PMC3123853, DOI: 10.1016/j.ajpath.2011.03.032.
Intensive Care Unit Management of Status Asthmaticus
Marshall P, Possick J, Chupp G. Intensive Care Unit Management of Status Asthmaticus. Clinical Pulmonary Medicine 2009, 16: 293-301. DOI: 10.1097/cpm.0b013e3181bdff38.
The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases
Ober C, Chupp GL. The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases. Current Opinion In Allergy And Clinical Immunology 2009, 9: 401-408. PMID: 19644363, PMCID: PMC3018778, DOI: 10.1097/aci.0b013e3283306533.
Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function
Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL. Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function. The New England Journal Of Medicine 2008, 358: 1682-1691. PMID: 18403759, PMCID: PMC2629486, DOI: 10.1056/nejmoa0708801.
A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma
Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M, Elias JA. A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma. The New England Journal Of Medicine 2007, 357: 2016-2027. PMID: 18003958, DOI: 10.1056/nejmoa073600.
Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death
Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death. Nature Medicine 2006, 12: 1286-1293. PMID: 17086189, PMCID: PMC2768268, DOI: 10.1038/nm1494.
Massive cavitary pulmonary rheumatoid nodules in a patient with HIV
Khazeni N, Homer RJ, Rubinowitz AN, Chupp GL. Massive cavitary pulmonary rheumatoid nodules in a patient with HIV. European Respiratory Journal 2006, 28: 872-874. PMID: 17012633, DOI: 10.1183/09031936.06.00144105.
Transgenic Modeling of Transforming Growth Factor-β1
Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA. Transgenic Modeling of Transforming Growth Factor-β1. Annals Of The American Thoracic Society 2006, 3: 418-423. PMID: 16799085, PMCID: PMC2658706, DOI: 10.1513/pats.200602-017aw.
Yoga intervention for adults with mild-to-moderate asthma: a pilot study
Sabina AB, Williams A, Wall HK, Bansal S, Chupp G, Katz DL. Yoga intervention for adults with mild-to-moderate asthma: a pilot study. Annals Of Allergy Asthma & Immunology 2005, 94: 543-548. PMID: 15945557, DOI: 10.1016/s1081-1206(10)61131-3.
Asthma: Mechanisms of Disease Persistence and Progression
Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.
PREFACE
CHUPP G. PREFACE. Clinics In Chest Medicine 2001, 22: xi. DOI: 10.1016/s0272-5231(05)70054-x.
Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks
O'Regan A, Nau G, Chupp G, Berman J. Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks. Trends In Immunology 2000, 21: 475-478. PMID: 11071524, DOI: 10.1016/s0167-5699(00)01715-1.
IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury
Corne J, Chupp G, Lee C, Homer R, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman A, Elias J. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. Journal Of Clinical Investigation 2000, 106: 783-791. PMID: 10995789, PMCID: PMC381393, DOI: 10.1172/jci9674.
Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection
Nau G, Chupp G, Emile J, Jouanguy E, Berman J, Casanova J, Young R. Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection. American Journal Of Pathology 2000, 157: 37-42. PMID: 10880373, PMCID: PMC1850209, DOI: 10.1016/s0002-9440(10)64514-2.
Airway remodeling in asthma
Elias J, Zhu Z, Chupp G, Homer R. Airway remodeling in asthma. Journal Of Clinical Investigation 1999, 104: 1001-1006. PMID: 10525034, PMCID: PMC408860, DOI: 10.1172/jci8124.
Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin
Nau G, Liaw L, Chupp G, Berman J, Hogan B, Young R. Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin. Infection And Immunity 1999, 67: 4223-4230. PMID: 10417195, PMCID: PMC96728, DOI: 10.1128/iai.67.8.4223-4230.1999.
A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis
Nau G, Guilfoile P, Chupp G, Berman J, Kim S, Kornfeld H, Young R. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6414-6419. PMID: 9177232, PMCID: PMC21064, DOI: 10.1073/pnas.94.12.6414.
Biological activity of interleukin-16
Cruikshank W, Kornfeld H, Berman J, Chupp G, Keane J, Center D. Biological activity of interleukin-16. Nature 1996, 382: 501-502. PMID: 8700223, DOI: 10.1038/382501b0.

Departments and Programs

Locations

Winchester Center for Lung Disease

Fitkin Memorial Pavilion

789 Howard Avenue, Ste 2nd floor

New Haven, CT 06519

1-203-495-2410

Directions

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Winchester Center for Lung Disease
Fitkin Memorial Pavilion
789 Howard Avenue, Ste 2nd floor
New Haven, CT 06519
- 1-203-495-2410
- Directions
Winchester Center for Lung Disease
North Haven Medical Center
6 Devine Street
North Haven, CT 06473
- 1-203-495-2410
- Directions

View Academic Profile

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Click here to view more about this specialist's research and educational efforts onhttps://medicine.yale.edu

Biography

He often helps patients who have complex disease that has been difficult to treat.

Titles

Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine )
Director, Yale Center for Asthma and Airways Disease (YCAAD), Pulmonary, Critical Care & Sleep Medicine
Director, Pulmonary Function Laboratory, Yale New Haven Hospital, Pulmonary, Critical Care & Sleep Medicine

Education & Training

MA
Yale University, Privatim (2017)
Fellow
Boston University School of Medicine (1997)
Resident
Tufts University/New England Medical Center (1993)
Intern
Tufts-New England Medical Center (1991)
MD
George Washington University (1990)
BS
Tufts University (1986)

Additional Information

Honors & Recognitions

Publications

PrecISE- A Biomarker Stratified Adaptive Trial of 5 Interventions in Severe Asthma: Final Protocol and the Baseline Cohort
Denlinger L, Israel E, Moore W, Georas S, Wright R, Castro M, Peden D, Anstrom K, Bleecker E, Alexander L, Cahill K, Cardet J, Carr T, Cedano J, Chen A, Chupp G, Comhair S, DiMango E, Erzurum S, Fahy J, Fajt M, Gaston B, Jackson D, Jain S, Jarjour N, Kenyon N, Kraft M, Krishnan J, Kumar R, Lugogo N, Martinez F, Marquis M, Pappalardo A, Phipatanakul W, Rank M, Rosenberg S, Salciccioli J, Sanchez M, Smith L, Sumino K, Szefler S, Tang M, Vijayanand P, Wechsler M, Wenzel S, White S, Zeki A, Ivanova A, Bacharier L, Akuthota P, Team N, Bleecker E, Carr T, Moore W, Rank M, Camacho G, Gerald L, Hastie A, Krings J, Martinez F, Merchen J, Meyers D, Nirendran N, Ortega V, Pippins A, Rusk A, Schunk R, Skeps R, Simmons T, Williamson P, Zein J, Israel E, Cardet J, DiMango E, Phipatanakul W, Bailey J, Banzon T, Bartnikas L, Baxi S, Betapudi V, Brick I, Casale T, Cinelli M, Crestani E, Cunningham A, Esty B, Fandozzi ;, Fernandez J, Fitzpatrick E, Flam B, Forth V, Gaffin J, Gentile K, Gueye-Ndiaye S, Haley K, Heromin R, Hauptmann M, Kaage T, Kelly M, Kraemer M, LaBere B, Lai P, Le M, Ledford D, Lee J, Lee J, Lockey R, Macginnitie A, McCarty K, Moss K, Mukharesh L, Pistenmaa A, Pepper A, Pimental M, Queheillalt D, Robinson A, Salciccioli J, Saroya T, Smith C, Trevedi M, Trippa L, Tulchinsky A, Vitiello A, Yee C, Zakar K, White T, Kumar R, Moy J, Rosenberg S, Aalemansour H, Buechler K, Carter T, Fu J, Hixon J, Jackson C, Ji Y, Johnson C, Kalhan R, Kane J, Kaur O, Li G, Lippner E, Makhija M, Maleckar S, Naureckas E, Nyenhuis S, Peters A, Press V, Qureshi M, Ryba D, Sheng J, Smith L, Xu B, Wechsler M, Szefler S, Chupp G, Holguin F, Kraft M, Liu A, Rogers L, Anderson D, Belimezova S, Bitzan J, Bose S, Brock J, Sanchez J, Clark B, Cohn L, Cotarian A, Cruse M, Eisenberg E, Estrom J, Glassmeyer I, Villalobos J, Grant N, Gruberg B, Guntur V, Hay O, Hills A, Hsieh J, Kessler J, Kolakowski C, Miyazawa N, Pak J, Pruitt D, Rhoads S, Sharma S, Stevens A, Tippin B, Valente C, Vicencio A, Wainscoat C, Weber J, Wessels G, White M, Winnica D, Zeitlin P, Denlinger L, Jarjour N, Krishnan J, Agnihotri N, Bach J, Bires N, DeLisa J, Fichtinger P, Floerke H, Fritz B, Grogan J, Guadarrama A, Hasse W, Jackson D, Kaspari R, Kelley R, Klaus D, Lowell P, Larson L, Norwick L, O’Brien M, Palas T, Pappalardo A, Read E, Schraml A, Schiebler M, Sorkness R, Tattersall M, Wollet L, Gaston B, Erzurum S, Teague W, Chmiel J, Ross K, Aronica M, Beck B, Bendy L, Borish L, Chedraoui C, Comhair S, Davis M, Dix A, Fakhry B, Gammell R, Gluvna A, Hamm E, Heskett M, Hu B, Khatri S, Kirwan J, Kloepfer K, Koo M, Labadia M, Marko A, Matheis N, Mey J, Mulya A, Murphy D, Owensby R, Parker L, Pennington E, Roesch E, Sharp J, Smith C, Solanki N, Veri L, Shifflett K, Yang F, Wenzel S, Lugogo N, Bagheri A, Cislo L, Fajt M, Gauthier M, Hadden M, James P, Mohan A, Moore J, Nouraie S, Ramonell R, Romanek R, Sullivan L, Trudeau J, Zhang M, Akuthota P, Jain S, Vijayanand P, Barry J, Beg N, Brickner H, Alexander L, Diaz D, Jafari Y, McKeon N, Fahy J, Kenyon N, Almario M, Charbit A, Cho L, Gale B, Haczku A, Harper R, Houston T, Kain C, Kivler C, Kuhn B, Liu M, McCourt P, Miller J, Nguyen A, Orain X, Peters M, Plough A, Ramirez K, Rossi L, Schivo M, Singapuri M, Teuber S, Tham T, Tompkins D, Vi J, Zeki A, Castro M, Bacharier L, Sumino K, Atha J, Boomer J, Cahill K, Clover A, Dorman V, Hoffman E, Jackson F, Klinck M, Krings J, Madison J, Quigley J, Quinones T, Saxena S, Sharpe M, Troyer J, Yen-Declue H, Zulich A, Ivanova A, Anstrom K, LaVange L, Bagaason S, Britt A, Bryan H, Burbank A, Chen A, Culpepper C, DeMarcus F, Fenu C, Gotman N, Green R, Harrison L, James J, Kosorok J, Kosorok M, Littleton L, Marquis M, O'Neal W, Peden D, Price R, Quibrera P, Ritz C, Sanchez M, Schwartz S, Slye N, Song T, Wilson N, Croxton T, Lu J, Noel P, Bamdad J, Georas S, Wright R. PrecISE- A Biomarker Stratified Adaptive Trial of 5 Interventions in Severe Asthma: Final Protocol and the Baseline Cohort. The Journal Of Allergy And Clinical Immunology 2026 PMID: 41707916, DOI: 10.1016/j.jaci.2026.02.001.
Switching to twice-yearly depemokimab from mepolizumab/benralizumab in severe asthma: A multicenter, randomized, double-blind, Phase 3A Clinical Trial (NIMBLE).
Chupp G, Nagase H, Skowasch D, Devouassoux G, Côté A, Jackson D, Jackson D, Wechsler M, Imber V, McGinniss J, K S, Howarth P, Pavord I. Switching to twice-yearly depemokimab from mepolizumab/benralizumab in severe asthma: A multicenter, randomized, double-blind, Phase 3A Clinical Trial (NIMBLE). American Journal Of Respiratory And Critical Care Medicine 2026 PMID: 41738176, DOI: 10.1093/ajrccm/aamag031.
Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma.
Kay S, Rajeevan H, Son M, Kwah J, Ramirez M, Liu Y, Wang Z, Yan X, Nino G, Britto C, Chupp G, Gomez J. Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma. American Journal Of Respiratory Cell And Molecular Biology 2025, 73: 884-896. PMID: 40587876, DOI: 10.1165/rcmb.2024-0565oc.
Mepolizumab in patients with severe asthma and blood eosinophil counts between 150 and 300 cells per µL: benefits at two years
Canonica G, Bagnasco D, Lee J, Chupp G, Schleich F, Oppenheimer J, Zhang L, Alfonso-Cristancho R, Howarth P. Mepolizumab in patients with severe asthma and blood eosinophil counts between 150 and 300 cells per µL: benefits at two years. ERJ Open Research 2025, 11: 01390-2024. PMID: 41220814, PMCID: PMC12598589, DOI: 10.1183/23120541.01390-2024.
Impact of Demographics on Mepolizumab Effectiveness in Severe Asthma: One-Year REALITI-A Subanalysis
Chupp G, Heaney L, Pelaia G, Almonacid C, Maxwell A, Zhang L, Alfonso-Cristancho R, Howarth P, Brusselle G. Impact of Demographics on Mepolizumab Effectiveness in Severe Asthma: One-Year REALITI-A Subanalysis. The Journal Of Allergy And Clinical Immunology In Practice 2025, 13: 3286-3295. PMID: 40780384, DOI: 10.1016/j.jaip.2025.07.049.
Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma
Caruso C, Canonica G, Patel M, Smith A, Liu M, Alfonso-Cristancho R, Price R, Jakes R, Demetriou L, Valero A, Köhler T, Pilette C, Chupp G, Brusselle G, Howarth P. Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma. CHEST Pulmonary 2025, 3: 100107. DOI: 10.1016/j.chpulm.2024.100107.
Maintenance of an Asthma Intervention Post-Trial: Use of a Patient-Activated Reliever-Triggered Inhaled Corticosteroid (PARTICS) Strategy in Black and Latinx Patients
Cardet J, Bailey J, Hurley L, Maher N, Staton E, Yawn B, Zaeh S, Israel E, investigators; O, Apter A, Bradford P, Calderon-Candelario R, Carroll J, Chupp G, Cohen R, Ericson B, Fuhlbrigge A, Kaplan B, Kruse J, Nazario S, Pace W, Pasarica M, Phipatanakul W, Riley I, Rodriguez-Louis J, Shenoy K, Stranges P, Tapp H, Wechsler M. Maintenance of an Asthma Intervention Post-Trial: Use of a Patient-Activated Reliever-Triggered Inhaled Corticosteroid (PARTICS) Strategy in Black and Latinx Patients. The Journal Of The American Board Of Family Medicine 2025, 38: 378-382. PMID: 40578913, PMCID: PMC12616832, DOI: 10.3122/jabfm.2024.240014r2.
The next frontier Defining and optimizing treatments for patients with type 2 low asthma
Zidan E, Wilson G, Shin J, Chupp G. The next frontier Defining and optimizing treatments for patients with type 2 low asthma. Annals Of Allergy Asthma & Immunology 2024, 134: 3-4. PMID: 39414022, DOI: 10.1016/j.anai.2024.10.013.
Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils
Buchheit K, Shaw D, Chupp G, Lehtimaki L, Heffler E, Finney‐Hayward T, Zangrilli J, Kwiatek J, Siddiqui S, Roufosse F, Thamboo A, West N, Vichiendilokkul A, Hellings P, Peters A, Howarth P. Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils. Allergy 2024, 79: 2662-2679. PMID: 39359069, DOI: 10.1111/all.16303.
Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma
Wilson G, Gautam S, Chupp G. Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma. Biomedicines 2024, 12: 2011. PMID: 39335525, PMCID: PMC11428232, DOI: 10.3390/biomedicines12092011.
Adoption and implementation of maintenance and reliever therapy for adults with moderate-to-severe asthma
Zaeh S, Zimmerman Z, Eakin M, Chupp G. Adoption and implementation of maintenance and reliever therapy for adults with moderate-to-severe asthma. Annals Of Allergy Asthma & Immunology 2024, 133: 318-324. PMID: 38897404, PMCID: PMC11344662, DOI: 10.1016/j.anai.2024.06.011.
Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma Across Multiple Clinically Relevant Subgroups in the NAVIGATOR Study
Carr T, Moore W, Kraft M, Brusselle G, Castro M, Chupp G, Wechsler M, Hunter G, Lindsley A, Llanos J, Burke L, Chandarana S, Ambrose C. Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma Across Multiple Clinically Relevant Subgroups in the NAVIGATOR Study. Advances In Therapy 2024, 41: 2978-2990. PMID: 38802635, PMCID: PMC11213736, DOI: 10.1007/s12325-024-02889-8.
Asthma control in the United States Relationships between short-acting β2-agonist and systemic corticosteroid use
Chupp G, Murphy K, Gandhi H, Gilbert I, Bleecker E. Asthma control in the United States Relationships between short-acting β2-agonist and systemic corticosteroid use. Annals Of Allergy Asthma & Immunology 2024, 133: 302-309. PMID: 38740134, DOI: 10.1016/j.anai.2024.05.003.
MELTEMI and COLUMBA: 5-Year Comparative Safety Analysis of Benralizumab and Mepolizumab
Bourdin A, Chupp G, Jackson D, Cohen D, Emerath U, Shavit A, Kurdyukova Y, Menzies-Gow A. MELTEMI and COLUMBA: 5-Year Comparative Safety Analysis of Benralizumab and Mepolizumab. The Journal Of Allergy And Clinical Immunology In Practice 2024, 12: 2074-2083.e4. PMID: 38677588, DOI: 10.1016/j.jaip.2024.04.033.
Activated sputum eosinophils associated with exacerbations in children on mepolizumab
Wilson G, Knight J, Liu Q, Shelar A, Stewart E, Wang X, Yan X, Sanders J, Visness C, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Activated sputum eosinophils associated with exacerbations in children on mepolizumab. The Journal Of Allergy And Clinical Immunology 2024, 154: 297-307.e13. PMID: 38485057, PMCID: PMC11305967, DOI: 10.1016/j.jaci.2024.01.031.
Targeting Asthma Remission as the Next Therapeutic Step Toward Improving Disease Control
Busse W, Chupp G, Corbridge T, Stach-Klysh A, Oppenheimer J. Targeting Asthma Remission as the Next Therapeutic Step Toward Improving Disease Control. The Journal Of Allergy And Clinical Immunology In Practice 2024, 12: 894-903. PMID: 38320720, DOI: 10.1016/j.jaip.2024.01.044.
Implementing Antiinflammatory Reliever Strategies in Asthma The Evolving Paradigm of Asthma Management
Zaeh S, Eakin M, Chupp G. Implementing Antiinflammatory Reliever Strategies in Asthma The Evolving Paradigm of Asthma Management. Chest 2024, 165: 250-252. PMID: 38336438, DOI: 10.1016/j.chest.2023.09.004.
Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma
Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.
Correction: iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects
Liu Y, Zhao J, Adams T, Wang N, Schupp J, Wu W, McDonough J, Chupp G, Kaminski N, Wang Z, Yan X. Correction: iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects. BMC Bioinformatics 2023, 24: 394. PMID: 37858060, PMCID: PMC10588114, DOI: 10.1186/s12859-023-05523-6.
iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects
Liu Y, Zhao J, Adams T, Wang N, Schupp J, Wu W, McDonough J, Chupp G, Kaminski N, Wang Z, Yan X. iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects. BMC Bioinformatics 2023, 24: 318. PMID: 37608264, PMCID: PMC10463720, DOI: 10.1186/s12859-023-05432-8.
Mepolizumab Reduces Systemic Corticosteroid Use in Chronic Rhinosinusitis With Nasal Polyps
Chupp G, Alobid I, Lugogo N, Kariyawasam H, Bourdin A, Chaker A, Smith S, Sousa A, Mayer B, Chan R, Matucci A. Mepolizumab Reduces Systemic Corticosteroid Use in Chronic Rhinosinusitis With Nasal Polyps. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3504-3512.e2. PMID: 37586475, DOI: 10.1016/j.jaip.2023.08.015.
Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19
Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.
Is there a best strategy to prevent asthma exacerbations in inner-city patients with asthma?
Zaeh S, Chupp G, Eakin M. Is there a best strategy to prevent asthma exacerbations in inner-city patients with asthma? Annals Of Allergy Asthma & Immunology 2023, 132: 11-12. PMID: 37433383, PMCID: PMC10774450, DOI: 10.1016/j.anai.2023.07.003.
Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials
Corren J, Menzies-Gow A, Chupp G, Israel E, Korn S, Cook B, Ambrose C, Hellqvist Å, Roseti S, Molfino N, Llanos J, Martin N, Bowen K, Griffiths J, Parnes J, Colice G. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 13-24. PMID: 37015033, PMCID: PMC10870853, DOI: 10.1164/rccm.202210-2005oc.
Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study
Menzies-Gow A, Bourdin A, Chupp G, Israel E, Hellqvist Å, Hunter G, Roseti S, Ambrose C, Llanos J, Cook B, Corren J, Colice G. Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study. Annals Of Allergy Asthma & Immunology 2023, 131: 343-348.e2. PMID: 37263380, DOI: 10.1016/j.anai.2023.05.028.
Dupilumab improves long‐term outcomes in patients with uncontrolled, moderate‐to‐severe GINA‐based type 2 asthma, irrespective of allergic status
Rabe K, Pavord I, Busse W, Chupp G, Izuhara K, Altincatal A, Gall R, Pandit‐Abid N, Deniz Y, Rowe P, Jacob‐Nara J, Radwan A. Dupilumab improves long‐term outcomes in patients with uncontrolled, moderate‐to‐severe GINA‐based type 2 asthma, irrespective of allergic status. Allergy 2023, 78: 2148-2156. PMID: 37073882, DOI: 10.1111/all.15747.
Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study
Pavord I, Gardiner F, Heaney L, Domingo C, Price R, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P. Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study. Frontiers In Immunology 2023, 14: 1150162. PMID: 37122713, PMCID: PMC10131245, DOI: 10.3389/fimmu.2023.1150162.
Efficacy and safety of tezepelumab in patients with uncontrolled disease while receiving maintenance therapy for moderate or severe asthma
Corren J, Wechsler M, Chupp G, Roseti S, Hellqvist Å, Martin N, Llanos J, Ambrose C, Colice G. Efficacy and safety of tezepelumab in patients with uncontrolled disease while receiving maintenance therapy for moderate or severe asthma. The Journal Of Allergy And Clinical Immunology In Practice 2022, 11: 943-945.e2. PMID: 36375743, DOI: 10.1016/j.jaip.2022.10.042.
Asthma exacerbations during the pandemic: Time to rethink clinical markers
Ortega H, Katz L, Chupp G. Asthma exacerbations during the pandemic: Time to rethink clinical markers. Journal Of Allergy And Clinical Immunology Global 2022, 2: 97-100. PMID: 36281240, PMCID: PMC9581642, DOI: 10.1016/j.jacig.2022.09.003.
Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults
Shlipak M, Sheshadri A, Hsu F, Chen S, Jotwani V, Tranah G, Fielding R, Liu C, Ix J, Coca S, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Leeuwenburgh J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Beard V, Tsiroyannis E, Hau C, Manini T, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rushing J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Sweeney Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Hankinson J, Vaz Fragoso C, Groessl E, Kaplan R. Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults. JAMA Internal Medicine 2022, 182: 650-659. PMID: 35499834, PMCID: PMC9062767, DOI: 10.1001/jamainternmed.2022.1449.
Mepolizumab Reduces Hypereosinophilic Syndrome Flares Irrespective of Blood Eosinophil Count and Interleukin-5
Rothenberg M, Roufosse F, Faguer S, Gleich G, Steinfeld J, Yancey S, Mavropoulou E, Kwon N, Group H, García G, Sosso A, Wehbe L, Yañez A, Blockmans D, Roufosse F, Antila M, Blanco D, Grava S, Lima M, Pez A, Faguer S, Hamidou M, Kahn J, Lefévre G, Brockow K, Kern P, Reiter A, Walz B, Welte T, Pane F, Vannucchi A, Cerino-Javier R, Gazca-Aguilar A, Hernández-Colín D, Valdéz-López H, Kupryś-Lipińska I, Musial J, Prejzner W, Mihaly E, Popov V, Zdrenghea M, Gritsaev S, Ivanov V, Tsyba N, Alonso A, Xutgla M, Fox M, Delgado R, Rivas J, Santillana G, González A, Wardlaw A, Akuthota P, Butterfield J, Chupp G, Cox J, Gleich G, Jhaveri D, Rothenberg M. Mepolizumab Reduces Hypereosinophilic Syndrome Flares Irrespective of Blood Eosinophil Count and Interleukin-5. The Journal Of Allergy And Clinical Immunology In Practice 2022, 10: 2367-2374.e3. PMID: 35568330, DOI: 10.1016/j.jaip.2022.04.037.
Natural history of disease burden for US patients with asthma vs asthma and COPD
Bleecker E, Murphy K, Gandhi H, Gilbert I, Zein J, Reibman J, Chupp G. Natural history of disease burden for US patients with asthma vs asthma and COPD. 2020, 1397. DOI: 10.1183/13993003.congress-2020.1397.
Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control Measure
Murphy K, Chipps B, Beuther D, Wise R, McCann W, Gilbert I, Eudicone J, Gandhi H, Harding G, Coyne K, Zeiger R, Board P, Kobernick A, Mohammad A, Cherry A, Fein A, Gaines A, Ramsey A, Michaud A, Palmer A, Kim A, Smith A, White A, Ricci A, Kettelhut B, Modena B, Stone B, Rolston B, Schnapf B, Krajicek B, Kraft C, Hopkins C, Natalie C, Anderson C, Czajkowski C, Arce D, Hamlin D, Hill D, Mares D, Pham D, Liao D, Simmons D, Johnson D, Jhaveri D, Maselli D, Kerwin E, Schuman E, Sher E, Bleecker E, Rakowski E, Hsu F, Averill F, Barsanti F, Gross G, Chupp G, Head G, Nasir H, Lee H, Barjaktarevic I, Cook J, Krainson J, Pearl J, Bellak J, Perez-Fernandez J, Rehm J, Trevor J, Most J, Hanson J, Blessing-Moore J, Biller J, Gedell J, Southard J, Chancellor J, Ilowite J, Romeo J, Mercado J, Fisher J, Greiwe J, Gregory K, Nadeau K, Shenoy K, Tan L, Stefanowicz L, Humes L, Bowers L, O’Connor M, Perez M, White M, Hegewald M, Wilson M, Sikora M, Morganroth M, Smith M, Farooqui N, Lesch N, Jain N, Parikh N, Hartog N, Luthin P, Stewart P, O’Connor P, Schochet P, Goldberg P, Patel P, Chinthrajah R, Sidhu R, Ayinla R, Brown R, Stadtler R, Wachs R, Balkissoon R, Duplantier R, Puente R, Settipane R, Mustafa S, Surani S, Jawad S, Adams S, Villegas S, Al-Farra S, Subramanian S, Bains S, Kelsen S, Wise S, Estrella-Eades S, Smith S, Qureshi T, Chen T, Kelbel T, Miller T, Jain V, Soong W, Soler X, Mattar Z. Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control Measure. The Journal Of Allergy And Clinical Immunology In Practice 2020, 8: 2263-2274.e5. PMID: 32387166, DOI: 10.1016/j.jaip.2020.02.042.
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability
Glynn N, Gmelin T, Santanasto A, Lovato L, Lange‐Maia B, Nicklas B, Fielding R, Manini T, Myers V, Rekeneire N, Spring B, Pahor M, King A, Rejeski W, Newman A, Pahor M, Guralnik J, Anton S, Buford T, Leeuwenburgh C, Nayfield S, Manini T, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Joyce K, Lovato L, Pierce J, Roberson W, Robertson J, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Chen S, Pierce J, Chen H, Hadley E, Romashkan S, Patel K, Bethesda, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor‐Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Yank V, Berra K, Bell C, Thiessen R, Youngman K, Virgen S, Maldonado E, Tarin K, Klaftenegger H, Prosak C, Campero I, Garcia D, Soto J, Chio L, Hoskins D, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Krol J, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Nayfield S, Sandesara B, Black M, Burk W, Hoover B, Knaggs J, Marena W, Korytov I, Curtis S, Lorow M, Goswami C, Lewis M, Kamen M, Bitz J, Stanton B, Hicks T, Gay C, Xie C, Morris H, Singletary F, Causer J, Yonce S, Radcliff K, Smith M, Scott J, Rodriguez M, Fitch M, Dunn M, Schllesinger J, Newman A, Studenski S, Goodpaster B, Lopez O, Glynn N, Nadkarni N, Ives D, Newman M, Grove G, Williams K, Bonk J, Rush J, Kost P, Vincent P, Gerger A, Romeo J, Monheim L, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer‐Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, Rekeneire N, McGloin J, Mautner R, Huie‐White S, Bianco L, Zocher J, Wu K, Shepard D, Fennelly B, Castro R, Halpin S, Brennan M, Barnett T, Iannone L, Zenoni M, Bugaj J, Bailey C, Charpentier P, Hawthorne‐Jones G, Mignosa B, Lewis L, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Vaz Fragoso C, Groessl E, Kaplan R. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability. Journal Of The American Geriatrics Society 2019, 68: 619-624. PMID: 31867713, PMCID: PMC8061638, DOI: 10.1111/jgs.16274.
Biomarkers, Targeted Therapies, Biologics, and Bronchial Thermoplasty
Mohan A, Grace J, Mainardi A, Chupp G, Lugogo N. Biomarkers, Targeted Therapies, Biologics, and Bronchial Thermoplasty. Respiratory Medicine 2019, 123-153. DOI: 10.1007/978-3-030-20812-7_8.
Measurement of Chitinase Activity in Biological Samples
Amick A, Liu Q, Gautam S, Chupp G, Dela Cruz C, Sharma L. Measurement of Chitinase Activity in Biological Samples. Journal Of Visualized Experiments 2019 DOI: 10.3791/60159-v.
Rapid onset of effect of benralizumab on morning peak expiratory flow in severe, uncontrolled asthma
Chupp G, Lugogo N, Kline J, Ferguson G, Hirsch I, Goldman M, Zangrilli J, Trudo F. Rapid onset of effect of benralizumab on morning peak expiratory flow in severe, uncontrolled asthma. Annals Of Allergy Asthma & Immunology 2019, 122: 478-485. PMID: 30802500, DOI: 10.1016/j.anai.2019.02.016.
Anti–IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison
Busse W, Chupp G, Nagase H, Albers F, Doyle S, Shen Q, Bratton D, Gunsoy N. Anti–IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison. The Journal Of Allergy And Clinical Immunology 2018, 143: 190-200.e20. PMID: 30205189, DOI: 10.1016/j.jaci.2018.08.031.
Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study
Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Salem W, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. The Journals Of Gerontology Series B 2017, 73: 1501-1513. PMID: 28482106, PMCID: PMC6178963, DOI: 10.1093/geronb/gbx051.
Multiparameter Single Cell Profiling of Airway Inflammatory Cells
Yao Y, Welp T, Liu Q, Niu N, Wang X, Britto CJ, Krishnaswamy S, Chupp G, Montgomery RR. Multiparameter Single Cell Profiling of Airway Inflammatory Cells. Cytometry Part B Clinical Cytometry 2017, 92: 12-20. PMID: 27807928, PMCID: PMC5250532, DOI: 10.1002/cyto.b.21491.
Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients
Silkoff P, Laviolette M, Singh D, FitzGerald J, Kelsen S, Backer V, Porsbjerg C, Girodet P, Berger P, Kline J, Chupp G, Susulic V, Barnathan E, Baribaud F, Loza M, investigators A, Strambu I, Lam S, Eich A, Ludwig-Sengpiel A, Leigh R, Dransfield M, Calhoun W, Hussaini A, Chanez P. Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients. The Journal Of Allergy And Clinical Immunology 2017, 140: 710-719. PMID: 28089872, DOI: 10.1016/j.jaci.2016.11.038.
Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study
Aubertin-Leheudre M, Anton S, Beavers D, Manini T, Fielding R, Newman A, Church T, Kritchevsky S, Conroy D, McDermott M, Botoseneanu A, Hauser M, Pahor M, Gill T, Fragoso C, Fielding R, Hauser M, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler M, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. Journal Of The American Medical Directors Association 2016, 18: 312-319. PMID: 27914851, PMCID: PMC5366275, DOI: 10.1016/j.jamda.2016.10.001.
Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study
Layne AS, Hsu FC, Blair SN, Chen SH, Dungan J, Fielding RA, Glynn NW, Hajduk AM, King AC, Manini TM, Marsh AP, Pahor M, Pellegrini CA, Buford TW, Investigators L, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study. Archives Of Physical Medicine And Rehabilitation 2016, 98: 11-24.e3. PMID: 27568165, PMCID: PMC5183463, DOI: 10.1016/j.apmr.2016.07.019.
The role of mepolizumab in atopic and nonatopic severe asthma with persistent eosinophilia
Ortega H, Chupp G, Bardin P, Bourdin A, Garcia G, Hartley B, Yancey S, Humbert M. The role of mepolizumab in atopic and nonatopic severe asthma with persistent eosinophilia. European Respiratory Journal 2014, 44: 239-241. PMID: 24659543, DOI: 10.1183/09031936.00220413.
The Lifestyle Interventions and Independence for Elders Study: Design and Methods
Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu FC, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M. The Lifestyle Interventions and Independence for Elders Study: Design and Methods. The Journals Of Gerontology Series A 2011, 66A: 1226-1237. PMID: 21825283, PMCID: PMC3193523, DOI: 10.1093/gerona/glr123.
Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood
Bjornsdottir US, Holgate ST, Reddy PS, Hill AA, McKee CM, Csimma CI, Weaver AA, Legault HM, Small CG, Ramsey RC, Ellis DK, Burke CM, Thompson PJ, Howarth PH, Wardlaw AJ, Bardin PG, Bernstein DI, Irving LB, Chupp GL, Bensch GW, Bensch GW, Stahlman JE, Karetzky M, Baker JW, Miller RL, Goodman BH, Raible DG, Goldman SJ, Miller DK, Ryan JL, Dorner AJ, Immermann FW, O'Toole M. Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood. PLOS ONE 2011, 6: e21902. PMID: 21779351, PMCID: PMC3136489, DOI: 10.1371/journal.pone.0021902.
Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model
Ramaprakash H, Shibata T, Duffy KE, Ismailoglu UB, Bredernitz RM, Moreira AP, Coelho AL, Das AM, Fursov N, Chupp GL, Hogaboam CM. Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model. American Journal Of Pathology 2011, 179: 104-115. PMID: 21640974, PMCID: PMC3123853, DOI: 10.1016/j.ajpath.2011.03.032.
Intensive Care Unit Management of Status Asthmaticus
Marshall P, Possick J, Chupp G. Intensive Care Unit Management of Status Asthmaticus. Clinical Pulmonary Medicine 2009, 16: 293-301. DOI: 10.1097/cpm.0b013e3181bdff38.
The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases
Ober C, Chupp GL. The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases. Current Opinion In Allergy And Clinical Immunology 2009, 9: 401-408. PMID: 19644363, PMCID: PMC3018778, DOI: 10.1097/aci.0b013e3283306533.
Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function
Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL. Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function. The New England Journal Of Medicine 2008, 358: 1682-1691. PMID: 18403759, PMCID: PMC2629486, DOI: 10.1056/nejmoa0708801.
A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma
Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M, Elias JA. A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma. The New England Journal Of Medicine 2007, 357: 2016-2027. PMID: 18003958, DOI: 10.1056/nejmoa073600.
Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death
Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death. Nature Medicine 2006, 12: 1286-1293. PMID: 17086189, PMCID: PMC2768268, DOI: 10.1038/nm1494.
Massive cavitary pulmonary rheumatoid nodules in a patient with HIV
Khazeni N, Homer RJ, Rubinowitz AN, Chupp GL. Massive cavitary pulmonary rheumatoid nodules in a patient with HIV. European Respiratory Journal 2006, 28: 872-874. PMID: 17012633, DOI: 10.1183/09031936.06.00144105.
Transgenic Modeling of Transforming Growth Factor-β1
Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA. Transgenic Modeling of Transforming Growth Factor-β1. Annals Of The American Thoracic Society 2006, 3: 418-423. PMID: 16799085, PMCID: PMC2658706, DOI: 10.1513/pats.200602-017aw.
Yoga intervention for adults with mild-to-moderate asthma: a pilot study
Sabina AB, Williams A, Wall HK, Bansal S, Chupp G, Katz DL. Yoga intervention for adults with mild-to-moderate asthma: a pilot study. Annals Of Allergy Asthma & Immunology 2005, 94: 543-548. PMID: 15945557, DOI: 10.1016/s1081-1206(10)61131-3.
Asthma: Mechanisms of Disease Persistence and Progression
Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.
PREFACE
CHUPP G. PREFACE. Clinics In Chest Medicine 2001, 22: xi. DOI: 10.1016/s0272-5231(05)70054-x.
Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks
O'Regan A, Nau G, Chupp G, Berman J. Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks. Trends In Immunology 2000, 21: 475-478. PMID: 11071524, DOI: 10.1016/s0167-5699(00)01715-1.
IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury
Corne J, Chupp G, Lee C, Homer R, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman A, Elias J. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. Journal Of Clinical Investigation 2000, 106: 783-791. PMID: 10995789, PMCID: PMC381393, DOI: 10.1172/jci9674.
Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection
Nau G, Chupp G, Emile J, Jouanguy E, Berman J, Casanova J, Young R. Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection. American Journal Of Pathology 2000, 157: 37-42. PMID: 10880373, PMCID: PMC1850209, DOI: 10.1016/s0002-9440(10)64514-2.
Airway remodeling in asthma
Elias J, Zhu Z, Chupp G, Homer R. Airway remodeling in asthma. Journal Of Clinical Investigation 1999, 104: 1001-1006. PMID: 10525034, PMCID: PMC408860, DOI: 10.1172/jci8124.
Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin
Nau G, Liaw L, Chupp G, Berman J, Hogan B, Young R. Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin. Infection And Immunity 1999, 67: 4223-4230. PMID: 10417195, PMCID: PMC96728, DOI: 10.1128/iai.67.8.4223-4230.1999.
A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis
Nau G, Guilfoile P, Chupp G, Berman J, Kim S, Kornfeld H, Young R. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6414-6419. PMID: 9177232, PMCID: PMC21064, DOI: 10.1073/pnas.94.12.6414.
Biological activity of interleukin-16
Cruikshank W, Kornfeld H, Berman J, Chupp G, Keane J, Center D. Biological activity of interleukin-16. Nature 1996, 382: 501-502. PMID: 8700223, DOI: 10.1038/382501b0.

Departments and Programs

Locations

Winchester Center for Lung Disease

Fitkin Memorial Pavilion

789 Howard Avenue, Ste 2nd floor

New Haven, CT 06519

1-203-495-2410

Directions

1 of 2

Winchester Center for Lung Disease
Fitkin Memorial Pavilion
789 Howard Avenue, Ste 2nd floor
New Haven, CT 06519
- 1-203-495-2410
- Directions
Winchester Center for Lung Disease
North Haven Medical Center
6 Devine Street
North Haven, CT 06473
- 1-203-495-2410
- Directions

Winchester Center for Lung Disease

Fitkin Memorial Pavilion

789 Howard Avenue, Ste 2nd floor

New Haven, CT 06519

1-203-495-2410

Directions

1 of 2

Winchester Center for Lung Disease
Fitkin Memorial Pavilion
789 Howard Avenue, Ste 2nd floor
New Haven, CT 06519
- 1-203-495-2410
- Directions
Winchester Center for Lung Disease
North Haven Medical Center
6 Devine Street
North Haven, CT 06473
- 1-203-495-2410
- Directions