Declan McGuone, MD, FRCPath Neuro, MBBCh
Anatomic Pathology, Autopsy Pathology, Neuropathology
Biography
Declan McGuone, MBBCh (a medical degree awarded outside the U.S.), is a neuropathologist who focuses on diagnosing diseases of the brain and nervous system. He also provides autopsy pathology to help determine causes of death and anatomic pathology to examine how disease affects tissues.
As an associate professor of pathology at Yale School of Medicine, Dr. McGuone investigates how certain tumors and injuries develop in the nervous system, with the aim of improving patient care.
He received his medical training from the Royal College of Surgeons in Ireland, completed a residency in anatomic pathology at Massachusetts General Hospital, and pursued fellowships in forensic pathology at the New York City Office of the Chief Medical Examiner and neuropathology at Massachusetts General Hospital.
Titles
- Associate Professor of Pathology
Education & Training
- Fellow (Forensic Pathology)New York City Office of the Chief Medical Examiner
- Resident (Anatomic Pathology)Massachusetts General Hospital
- FellowshipMassachusetts General Hospital (2014)
- Fellow (Neuropathology)Massachusetts General Hospital
- FellowshipFrenchay Hospital (2011)
- InternshipOur Lady of Lourdes Hospital (2004)
Additional Information
Publications
- Yalcin K, Alanya H, Gultekin B, Samper Figuera D, Barak T, Miyagishima D, Youngblood M, Hjerthen M, Brooks A, Samuel Lopez N, O’Brien J, Chavez M, Dincer A, Wu H, Omay S, Yasuno K, Bilguvar K, Ercan-Sencicek A, Mishra-Gorur K, McGuone D, Moliterno J, Gunel M, Erson-Omay E. Subgroup of meningiomas involving FOS and FOSB gene fusions. Nature Communications 2025, 16: 10532. PMID: 41298363, PMCID: PMC12657970, DOI: 10.1038/s41467-025-65549-7.
- Neuschmid S, Schallerer C, Ehrlich B, McGuone D. Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration. International Journal Of Molecular Sciences 2025, 26: 9245. PMID: 41009808, PMCID: PMC12471116, DOI: 10.3390/ijms26189245.
- Schallerer C, Neuschmid S, Ehrlich B, McGuone D. Calpain in Traumatic Brain Injury: From Cinderella to Central Player. Cells 2025, 14: 1253. PMID: 40862734, PMCID: PMC12384584, DOI: 10.3390/cells14161253.
- Dincer A, Kim M, Hüseyinoglu Z, Chavez M, McGuone D, Moliterno J. Reclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case. Journal Of Neurosurgery Case Lessons 2025, 9: case24778. PMID: 40324324, PMCID: PMC12051993, DOI: 10.3171/case24778.
- Mathew S, McGuone D, Patel K, Gopal P. TDP-43 Microvasculopathy Associated Astrogliosis and Blood-Brain Barrier Breach in the Context of Alzheimer’s Disease and COVID-19. Physiology 2025, 40: 0537. DOI: 10.1152/physiol.2025.40.s1.0537.
- Leelatian N, McGuone D. Neuropathology Intraoperative Consultation. Seminars In Diagnostic Pathology 2025, 42: 150899. PMID: 40203540, DOI: 10.1016/j.semdp.2025.150899.
- Narang S, Haney S, Duhaime A, Martin J, Binenbaum G, de Alba Campomanes A, Barth R, Bertocci G, Care M, McGuone D, Laskey A, Asnes A, Brown V, Girardet R, Heavilin N, Kissoon N, McGregory K, Morgan P, Rosado N, Flaherty E, Sirotnak A, Haney S, Gavril A, Hoffert Gilmartin A, Idzerda S, Messner S, Legano L, Mohr B, Moles R, Palusci V, Nienow S, Budzak A, Suh D, Yoo S, Dumitrescu A, Fredrick D, Gise R, Strominger M, Rubin S, Karr D, Nischal K, Roarty J, Otero H, Milla S, Mercado-Deane M, Alazraki A, Annam A, Benya E, Acharya P, Brown B, Barton K, Daugherty R, Albert G, Bauer D, Ducis K, Lam S, Martin J, Rocque B, Aldana P, Brockmeyer D, Duhaime A, Jea A, Otero H, Milla S, Mercado-Deane M, Alazraki A, Annam A, Benya E, Acharya P, Brown B, Barton K, Daugherty R, Albert G, Bauer D, Ducis K, Lam S, Martin J, Rocque B, Aldana P, Brockmeyer D, Duhaime A, Jea A. Abusive Head Trauma in Infants and Children: Technical Report. 2025, 155 PMID: 39992695, DOI: 10.1542/peds.2024-070457.
- Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.
- Gupta M, Samiappan S, Alanya H, Yalcin K, Gultekin B, Sharaf R, Elsamadicy A, Figuera D, Samuel N, Mishra-Gorur K, Kolb L, McGuone D, Gunel M, Erson-Omay E, Moliterno J, Mendel E. Somatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas. Neuro-Oncology Advances 2025, 7: vdaf067. PMID: 40386121, PMCID: PMC12081948, DOI: 10.1093/noajnl/vdaf067.
- Alanya H, Yalcin K, Hilton B, Gultekin B, Mishra-Gorur K, McGuone D, Gunel M, Omay S, Erson-Omay Z. EPCO-35. GENOMIC CHARACTERIZATION OF GROWTH HORMONE SECRETING PITUITARY ADENOMAS. Neuro-Oncology 2024, 26: viii9-viii9. PMCID: PMC11553213, DOI: 10.1093/neuonc/noae165.0034.
- Mikhaiel J, Parasram M, Park J, Cappucci S, McGuone D, Falcone G, Sheth K, Gilmore E. Rocky Mountain Spotted Fever Encephalitis and “Starry Sky” Pattern on MRI. The Neurologist 2024, 30: 34-38. PMID: 39382206, DOI: 10.1097/nrl.0000000000000586.
- Kandigian S, Chande S, Dolezal D, Tang T, Wang D, Arnal-Estapé A, Cheok S, McGuone D, Liu Y, Goldberg S, Blondin N, Chiang V, Nguyen D. BSLM-10 MOLECULAR AND HISTOLOGICAL CHARACTERIZATION OF NSCLC PROGRESSION TO LEPTOMENINGEAL METASTASIS WITH COMORBID INTRAPARENCHYMAL DISEASE. Neuro-Oncology Advances 2024, 6: i7-i7. PMCID: PMC11296776, DOI: 10.1093/noajnl/vdae090.020.
- Tabor J, O'Brien J, Valero S, Pappajohn A, McGuone D, Erson-Omay Z, Yasuno K, Gunel M, Moliterno J. Heterozygous CDKN2A Loss is Associated with Recurrence and Survival in High, But Not Low Grade Meningiomas. Neurosurgery 2024, 70: 203-203. DOI: 10.1227/neu.0000000000002810_112.
- Tabor J, Dincer A, O'Brien J, Lei H, Vetsa S, Vasandani S, Jalal M, Yalcin K, Morales-Valero S, Marianayagam N, Alanya H, Elsamadicy A, Millares Chavez M, Aguilera S, Mishra-Gorur K, McGuone D, Fulbright R, Jin L, Erson-Omay E, Günel M, Moliterno J. Variations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group. Journal Of Neurosurgery 2024, 141: 664-672. PMID: 38518289, DOI: 10.3171/2024.1.jns231633.
- Leitner D, William C, Faustin A, Kanshin E, Snuderl M, McGuone D, Wisniewski T, Ueberheide B, Gould L, Devinsky O. Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history. Acta Neuropathologica 2024, 148: 76. PMID: 39607506, PMCID: PMC11604820, DOI: 10.1007/s00401-024-02832-9.
- Kapate N, Liao R, Sodemann R, Stinson T, Prakash S, Kumbhojkar N, Suja V, Wang L, Flanz M, Rajeev R, Villafuerte D, Shaha S, Janes M, Park K, Dunne M, Golemb B, Hone A, Adebowale K, Clegg J, Slate A, McGuone D, Costine-Bartell B, Mitragotri S. Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury. PNAS Nexus 2023, 3: pgad434. PMID: 38187808, PMCID: PMC10768983, DOI: 10.1093/pnasnexus/pgad434.
- Tabor J, Chavez M, O'Brien J, Morales-Valero S, Pappajohn A, McGuone D, Erson-Omay Z, Yasuno K, Gunel M, Moliterno J. EPCO-47. HETEROZYGOUS CDKN2A LOSS IS ASSOCIATED WITH HIGHER RECURRENCE AND LOWER SURVIVAL IN HIGH-, BUT NOT LOW-GRADE MENINGIOMAS. Neuro-Oncology 2023, 25: v134-v135. PMCID: PMC10639255, DOI: 10.1093/neuonc/noad179.0509.
- Mohammed F, Mcguone D, Omay S, Omay Z, Zhou J. A PILOT STUDY: SPATIOTEMPORALLY-RESOLVED MOLECULAR MECHANISMS OF ACUTE IMMUNE AND NEUROMODULATORY RESPONSES TO TRAUMATIC BRAIN INJURY. IBRO Neuroscience Reports 2023, 15: s189-s190. DOI: 10.1016/j.ibneur.2023.08.289.
- Dincer A, Jalal M, Gupte T, Vetsa S, Vasandani S, Yalcin K, Marianayagam N, Blondin N, Corbin Z, McGuone D, Fulbright R, Erson-Omay Z, Günel M, Moliterno J. The clinical and genomic features of seizures in meningiomas. Neuro-Oncology Advances 2023, 5: i49-i57. PMID: 37287582, PMCID: PMC10243847, DOI: 10.1093/noajnl/vdac110.
- Miyagishima D, Sundaresan V, Gutierrez A, Barak T, Yeung J, Moliterno J, McGuone D, Claus E, Günel M. A systematic review and individual participant data meta-analysis of gonadal steroid hormone receptors in meningioma. Journal Of Neurosurgery 2023, 139: 1638-1647. PMID: 37243565, PMCID: PMC10226381, DOI: 10.3171/2023.3.jns221838.
- Tabor J, O'Brien J, Vasandani S, Vetsa S, Lei H, Jalal M, Marianayagam N, Jin L, Millares Chavez M, Haynes J, Dincer A, Yalcin K, Aguilera S, Omay S, Mishra-Gorur K, McGuone D, Morales-Valero S, Fulbright R, Gunel M, Erson-Omay E, Moliterno J. Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas. Journal Of Neurosurgery 2023, 139: 1648-1656. PMID: 37243548, DOI: 10.3171/2023.4.jns222929.
- Galbraith K, Vasudevaraja V, Serrano J, Shen G, Tran I, Abdallat N, Wen M, Patel S, Movahed-Ezazi M, Faustin A, Spino-Keeton M, Roberts L, Maloku E, Drexler S, Liechty B, Pisapia D, Krasnozhen-Ratush O, Rosenblum M, Shroff S, Boué D, Davidson C, Mao Q, Suchi M, North P, Hopp A, Segura A, Jarzembowski J, Parsons L, Johnson M, Mobley B, Samore W, McGuone D, Gopal P, Canoll P, Horbinski C, Fullmer J, Farooqi M, Gokden M, Wadhwani N, Richardson T, Umphlett M, Tsankova N, DeWitt J, Sen C, Placantonakis D, Pacione D, Wisoff J, Hidalgo E, Harter D, William C, Cordova C, Kurz S, Barbaro M, Orringer D, Karajannis M, Sulman E, Gardner S, Zagzag D, Tsirigos A, Allen J, Golfinos J, Snuderl M. Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing. Neuro-Oncology Advances 2023, 5: vdad076. PMID: 37476329, PMCID: PMC10355794, DOI: 10.1093/noajnl/vdad076.
- Erson-Omay EZ, Vetsa S, Vasandani S, Barak T, Nadar A, Marianayagam NJ, Yalcin K, Miyagishima D, Aguilera SM, Robert S, Mishra-Gorur K, Fulbright RK, McGuone D, Günel M, Moliterno J. Genomic profiling of sporadic multiple meningiomas. BMC Medical Genomics 2022, 15: 112. PMID: 35568945, PMCID: PMC9107270, DOI: 10.1186/s12920-022-01258-0.
- Leitner DF, William C, Faustin A, Askenazi M, Kanshin E, Snuderl M, McGuone D, Wisniewski T, Ueberheide B, Gould L, Devinsky O. Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood. Acta Neuropathologica 2022, 143: 585-599. PMID: 35333953, PMCID: PMC8953962, DOI: 10.1007/s00401-022-02414-7.
- Nene A, Hong CS, McGuone D, Matouk CC, Omay SB. Staged endovascular treatment of a coexisting parasellar aneurysm and endoscopic resection of a pituitary macroadenoma: illustrative case. Journal Of Neurosurgery Case Lessons 2022, 3: case21699. PMID: 36130536, PMCID: PMC9379633, DOI: 10.3171/case21699.
- Abdelhakim S, Klapholz JD, Roy B, Weiss SA, McGuone D, Corbin ZA. Mononeuritis multiplex as a rare and severe neurological complication of immune checkpoint inhibitors: a case report. Journal Of Medical Case Reports 2022, 16: 81. PMID: 35197122, PMCID: PMC8867751, DOI: 10.1186/s13256-022-03290-1.
- Jin L, Vetsa S, Vasandani S, Nadar A, Youngblood M, Gupte T, Barak T, Yalcin K, Aguilera S, Mishra-Gorur K, Blondin N, Gorelick E, Omay S, Pointdujour-Lim R, Judson B, Alperovich M, Aboian M, Marianayagam N, McGuone D, Gunel M, Erson-Omay Z, Fulbright R, Moliterno J. TRAF7 Mutated Subgroups Differ in Sphenoid Wing Meningiomas with Hyperostosis. Journal Of Neurological Surgery Part B Skull Base 2022, 83: s1-s270. DOI: 10.1055/s-0042-1743640.
- Wang X, Habet V, Aboian M, Leelatian N, McGuone D, Morotti R, Kandil S, Darbinyan A. Neuropathology of Chiari Malformation II with Chromosome X Alterations: An Autopsy Study in a 17-Month-Old and Review of Literature. Journal Of Neuropathology & Experimental Neurology 2022, 81: 296-298. PMID: 35139536, DOI: 10.1093/jnen/nlab137.
- Jin L, Youngblood M, Gupte T, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera S, Mishra-Gorur K, Blondin N, Omay S, Pointdujour-Lim R, Judson B, Alperovich M, Aboian M, McGuone D, Gunel M, Erson-Omay Z, Fulbright R, Moliterno J. NIMG-64. TYPE OF BONY INVOLVEMENT PREDICTS GENOMIC SUBGROUP IN SPHENOID WING MENINGIOMAS. Neuro-Oncology 2021, 23: vi144-vi144. PMCID: PMC8598770, DOI: 10.1093/neuonc/noab196.562.
- Erson-Omay Z, Barak T, Vetsa S, Nadar A, Miyagishima D, Yalcin K, Aguilera S, Mishra-Gorur K, McGuone D, Fulbright R, Gunel M, Moliterno-Gunel J. EPCO-29. GENOMIC PROFILING OF SPORADIC MULTIPLE MENINGIOMAS. Neuro-Oncology 2021, 23: vi8-vi8. DOI: 10.1093/neuonc/noab196.028.
- Barak T, Vetsa S, Nadar A, Jin L, Gupte TP, Fomchenko EI, Miyagishima DF, Yalcin K, Vasandani S, Gorelick E, Zhao AY, Antonios J, Theriault BC, Lifton N, Marianayagam N, Omay B, Omay ZE, Huttner A, McGuone D, Blondin NA, Corbin Z, Fulbright RK, Moliterno J. Surgical strategies for older patients with glioblastoma. Journal Of Neuro-Oncology 2021, 155: 255-264. PMID: 34626296, PMCID: PMC8651607, DOI: 10.1007/s11060-021-03862-z.
- Johnson JE, McGuone D, Xu ML, Jane-Wit D, Mitchell RN, Libby P, Pober JS. Coronavirus Disease 2019 (COVID-19) Coronary Vascular Thrombosis Correlation with Neutrophil but Not Endothelial Activation. American Journal Of Pathology 2021, 192: 112-120. PMID: 34599881, PMCID: PMC8479934, DOI: 10.1016/j.ajpath.2021.09.004.
- Jin L, Youngblood MW, Gupte TP, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera SM, Mishra-Gorur K, Blondin NA, Gorelick E, Omay SB, Pointdujour-Lim R, Judson BL, Alperovich M, Aboian MS, McGuone D, Gunel M, Erson-Omay Z, Fulbright RK, Moliterno J. Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas. Journal Of Neuro-Oncology 2021, 154: 237-246. PMID: 34350560, DOI: 10.1007/s11060-021-03819-2.
- Brown SC, Cormier J, Tuan J, Lier AJ, McGuone D, Armstrong PM, Kaddouh F, Parikh S, Landry ML, Gobeske KT. Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 2042-2051. PMID: 34289334, PMCID: PMC8314835, DOI: 10.3201/eid2708.203730.
- Leitner DF, McGuone D, William C, Faustin A, Askenazi M, Snuderl M, Guzzetta M, Jarrell HS, Maloney K, Reichard R, Smith C, Weedn V, Wisniewski T, Gould L, Devinsky O. Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths. Neuropathology And Applied Neurobiology 2021, 48: e12746. PMID: 34164845, PMCID: PMC8777468, DOI: 10.1111/nan.12746.
- Wang Y, Iyer K, Mcguone D, Velazquez E, Maulion C. MY BLEEDING HEART: SEVERE THROMBOCYTOPENIA AND ACUTE INTRAMYOCARDIAL HEMORRHAGE. Journal Of The American College Of Cardiology 2021, 77: 2139. DOI: 10.1016/s0735-1097(21)03495-1.
- Hong CS, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Inzucchi SE, Omay SB, Erson-Omay EZ. Somatic NF1 mutations in pituitary adenomas: Report of two cases. Cancer Genetics 2021, 256: 26-30. PMID: 33862521, DOI: 10.1016/j.cancergen.2021.03.004.
- Costine-Bartell B, Price G, Shen J, McGuone D, Staley K, Duhaime AC. A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model. Neurobiology Of Disease 2021, 154: 105334. PMID: 33753291, PMCID: PMC8135256, DOI: 10.1016/j.nbd.2021.105334.
- Harowitz J, Crandall L, McGuone D, Devinsky O. Seizure‐related deaths in children: The expanding spectrum. Epilepsia 2021, 62: 570-582. PMID: 33586153, PMCID: PMC7986159, DOI: 10.1111/epi.16833.
- Hong CS, Kuzmik GA, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Blondin NA, DiLuna ML, Erson-Omay EZ. Hypermutated phenotype in gliosarcoma of the spinal cord. Npj Precision Oncology 2021, 5: 8. PMID: 33580181, PMCID: PMC7881101, DOI: 10.1038/s41698-021-00143-w.
- Hong CS, Omuro A, An Y, Inzucchi S, Kohli AA, McGuone D, Vining EM, Omay SB, Erson-Omay E. Sporadic adamantinomatous craniopharyngioma with double-hit somatic APC mutations. Neuro-Oncology Advances 2021, 3: vdab124. PMID: 34549183, PMCID: PMC8446933, DOI: 10.1093/noajnl/vdab124.
- McGuone D, Huttner A. Histopathology and Grading of Meningiomas. 2020, 11-24. DOI: 10.1007/978-3-030-59558-6_2.
- Gupte TP, Li C, Jin L, Yalcin K, Youngblood MW, Miyagishima DF, Mishra-Gorur K, Zhao AY, Antonios J, Huttner A, McGuone D, Blondin NA, Contessa JN, Zhang Y, Fulbright RK, Gunel M, Erson-Omay Z, Moliterno J. Clinical and genomic factors associated with seizures in meningiomas. Journal Of Neurosurgery 2020, 135: 835-844. PMID: 33276341, DOI: 10.3171/2020.7.jns201042.
- McGuone D, Crandall LG, Devinsky O. Sudden Unexplained Death in Childhood: A Neuropathology Review. Frontiers In Neurology 2020, 11: 582051. PMID: 33178125, PMCID: PMC7596260, DOI: 10.3389/fneur.2020.582051.
- S ., Kundishora AJ, Elsamadicy AA, Koo AB, Beckta JM, McGuone D, Erson-Omay EZ, Omay SB. Genetic characterization of a case of sellar metastasis from bronchial carcinoid neuroendocrine tumor. Surgical Neurology International 2020, 11: 303. PMID: 33093980, PMCID: PMC7568119, DOI: 10.25259/sni_265_2020.
- Hong C, McGuone D, Erson-Omay E, Omay S. 26. GENETIC CHARACTERIZATION OF SELLAR METASTASIS FROM PRIMARY BRONCHIAL CARCINOID TUMOR OF NEUROENDOCRINE PATHOLOGY. Neuro-Oncology Advances 2020, 2: ii4-ii5. PMCID: PMC7401391, DOI: 10.1093/noajnl/vdaa073.016.
- McGuone D, Sinard J, Gill JR, Masters A, Liu C, Morotti R, Parkash V. Autopsy Services and Emergency Preparedness of a Tertiary Academic Hospital Mortuary for the COVID-19 Public Health Emergency: The Yale Plan. Advances In Anatomic Pathology 2020, 27: 355-362. PMID: 32649315, DOI: 10.1097/pap.0000000000000274.
- Gummadavelli A, Dinauer C, McGuone D, Vining EM, Erson-Omay EZ, Omay SB. Large-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature. Journal Of Clinical Neuroscience 2020, 78: 420-422. PMID: 32336638, DOI: 10.1016/j.jocn.2020.04.103.
- McGuone D, Leitner D, William C, Faustin A, Leelatian N, Reichard R, Shepherd TM, Snuderl M, Crandall L, Wisniewski T, Devinsky O. Neuropathologic Changes in Sudden Unexplained Death in Childhood. Journal Of Neuropathology & Experimental Neurology 2020, 79: 336-346. PMID: 31995186, PMCID: PMC7036658, DOI: 10.1093/jnen/nlz136.
- Chen H, Thomas C, Munoz FA, Alexandrescu S, Horbinski CM, Olar A, McGuone D, Camelo-Piragua S, Wang L, Pentsova E, Phillips J, Aldape K, Chen W, Iafrate AJ, S AS, Zagzag D, Golfinos JG, Placantonakis DG, Rosenblum M, Ohman-Strickland P, Hameed M, Snuderl M. Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors. Neuro-Oncology 2019, 21: 1164-1174. PMID: 31140557, PMCID: PMC7571489, DOI: 10.1093/neuonc/noz098.
- Costine-Bartell B, McGuone D, Price G, Crawford E, Keeley K, Munoz-Pareja J, Dodge CP, Staley K, Duhaime AC. Development of a Model of Hemispheric Hypodensity (“Big Black Brain”). Journal Of Neurotrauma 2018, 36: 815-833. PMID: 30039743, PMCID: PMC6387571, DOI: 10.1089/neu.2018.5736.
- Gopal RK, Calvo SE, Shih AR, Chaves FL, McGuone D, Mick E, Pierce KA, Li Y, Garofalo A, Van Allen EM, Clish CB, Oliva E, Mootha VK. Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e6283-e6290. PMID: 29915083, PMCID: PMC6142220, DOI: 10.1073/pnas.1711888115.
- Stemmer-Rachamimov A, Laver N, McGuone D, Shah B, Weinstein G, Bedi H. Ophthalmic Diseases. 2017, 462-474. DOI: 10.1017/9781139696401.020.
- Folkerth RD, Nunez J, Georgievskaya Z, McGuone D. Neuropathologic Examination in Sudden Unexpected Deaths in Infancy and Childhood: Recommendations for Highest Diagnostic Yield and Cost-Effectiveness in Forensic Settings. Academic Forensic Pathology 2017, 7: 182-199. PMID: 31239973, PMCID: PMC6474536, DOI: 10.23907/2017.020.
- Lam JD, Oh DJ, Wong LL, Amarnani D, Park-Windhol C, Sanchez AV, Cardona-Velez J, McGuone D, Stemmer-Rachamimov AO, Eliott D, Bielenberg DR, van Zyl T, Shen L, Gai X, D'Amore PA, Kim LA, Arboleda-Velasquez JF. Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis. Diabetes 2017, 66: db161035. PMID: 28400392, PMCID: PMC5482092, DOI: 10.2337/db16-1035.
- Williams EA, McGuone D, Frosch MP, Hyman BT, Laver N, Stemmer-Rachamimov A. Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease. Journal Of Neuropathology & Experimental Neurology 2017, 76: 376-383. PMID: 28379416, PMCID: PMC7191616, DOI: 10.1093/jnen/nlx020.
- Chen H, Thomas C, Munoz F, Alexandrescu S, Horbinski C, Olar A, McGuone D, Camelo-Piragua S, Wang L, Pentsova E, Phillips J, Aldape K, Iafrate A, Golfinos J, Chi A, Zagzag D, Rosenblum M, Ohman-Strickland P, Hameed M, Snuderl M. MPTH-34. THE PROGNOSTIC VALUE OF POLYSOMY IN OLIGODENDROGLIAL TUMORS. Neuro-Oncology 2016, 18: vi113-vi113. DOI: 10.1093/neuonc/now212.471.
- Taylor SR, Smith CM, Keeley KL, McGuone D, Dodge CP, Duhaime AC, Costine BA. Neuroblast Distribution after Cortical Impact Is Influenced by White Matter Injury in the Immature Gyrencephalic Brain. Frontiers In Neuroscience 2016, 10: 387. PMID: 27601978, PMCID: PMC4994423, DOI: 10.3389/fnins.2016.00387.
- Bevers MB, McGuone D, Jerath NU, Musolino PL. Leptomeningeal transthyretin-type amyloidosis presenting as acute hydrocephalus and subarachnoid hemorrhage. Journal Of Clinical Neuroscience 2016, 29: 203-205. PMID: 26896372, DOI: 10.1016/j.jocn.2015.12.017.
- Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening. Scientific Reports 2015, 5: 16622. PMID: 26564777, PMCID: PMC4643219, DOI: 10.1038/srep16622.
- Marciscano AE, Stemmer-Rachamimov AO, Niemierko A, Larvie M, Curry WT, Barker FG, Martuza RL, McGuone D, Oh KS, Loeffler JS, Shih HA. Benign meningiomas (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes. Journal Of Neurosurgery 2015, 124: 106-14. PMID: 26274991, DOI: 10.3171/2015.1.jns142228.
- Kim LA, Wong LL, Amarnani DS, Bigger-Allen AA, Hu Y, Marko CK, Eliott D, Shah VA, McGuone D, Stemmer-Rachamimov AO, Gai X, D'Amore PA, Arboleda-Velasquez JF. Characterization of cells from patient-derived fibrovascular membranes in proliferative diabetic retinopathy. Molecular Vision 2015, 21: 673-87. PMID: 26120272, PMCID: PMC4462955.
- Shapiro KA, McGuone D, Deshpande V, Sadow PM, Stemmer-Rachamimov A, Staley KJ. Failure to detect human papillomavirus in focal cortical dysplasia type IIb. Annals Of Neurology 2015, 78: 63-67. PMID: 25893423, DOI: 10.1002/ana.24422.
- Costine BA, Missios S, Taylor SR, McGuone D, Smith CM, Dodge CP, Harris BT, Duhaime AC. The Subventricular Zone in the Immature Piglet Brain: Anatomy and Exodus of Neuroblasts into White Matter after Traumatic Brain Injury. Developmental Neuroscience 2015, 37: 115-130. PMID: 25678047, PMCID: PMC4406780, DOI: 10.1159/000369091.
- Burgin S, Stone J, Shenoy-Bhangle A, McGuone D. Case 18-2014. The New England Journal Of Medicine 2014, 370: 2327-2337. PMID: 24918376, DOI: 10.1056/nejmcpc1304161.
- Boland TA, McGuone D, Jindal J, Rocha M, Cumming M, Rupprecht CE, Barbosa TF, de Novaes Oliveira R, Chu CJ, Cole AJ, Kotait I, Kuzmina NA, Yager PA, Kuzmin IV, Hedley‐Whyte E, Brown CM, Rosenthal ES. Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies. Annals Of Neurology 2014, 75: 155-160. PMID: 24038455, PMCID: PMC4118733, DOI: 10.1002/ana.24016.
- Kay KR, Smith C, Wright AK, Serrano-Pozo A, Pooler AM, Koffie R, Bastin ME, Bak TH, Abrahams S, Kopeikina KJ, McGuone D, Frosch MP, Gillingwater TH, Hyman BT, Spires-Jones TL. Studying synapses in human brain with array tomography and electron microscopy. Nature Protocols 2013, 8: 1366-1380. PMID: 23787894, PMCID: PMC3712649, DOI: 10.1038/nprot.2013.078.
- Cole A, Eskandar E, Mela T, Noebels J, Gonzalez R, McGuone D. Case 18-2013. The New England Journal Of Medicine 2013, 368: 2304-2312. PMID: 23758236, DOI: 10.1056/nejmcpc1215969.
- McCarthy A, Farrell M, Hedley-Whyte T, McGuone D, Kavanagh E, McNally S, Keogan M, Horgan N, Lynch T, O’Rourke K. Granulomatosis with polyangiitis masquerading as giant cell arteritis. Journal Of Neurology 2013, 260: 1661-1663. PMID: 23579235, DOI: 10.1007/s00415-013-6913-3.
- Greer D, Robbins G, Lijewski V, Gonzalez R, McGuone D. Case 1-2013. The New England Journal Of Medicine 2013, 368: 172-180. PMID: 23301735, DOI: 10.1056/nejmcpc1209935.
- Kurian KM, McGuone D. Retrospective Case‐Control Study of Apolipoprotein J/Clusterin Protein Expression in Early Liveborn Neonatal Deaths with and without Pontosubicular Necrosis. Pathology Research International 2012, 2012: 479359. PMID: 22848862, PMCID: PMC3403500, DOI: 10.1155/2012/479359.
- Rice C, McGuone D, Kurian K, Love S, Renowden S, Giffin N. Autopsy-confirmed, co-existent CADASIL and multiple system atrophy. Parkinsonism & Related Disorders 2011, 17: 390-392. PMID: 21316291, DOI: 10.1016/j.parkreldis.2011.01.004.
- Mcguone D, Kay E. The impact of the organ retention controversy on the practice of hospital necropsy: a four year audit. Journal Of Clinical Pathology 2004, 57: 448. PMID: 15047757, PMCID: PMC1770284, DOI: 10.1136/jcp.2003.012633.
Departments and Programs
Biography
Declan McGuone, MBBCh (a medical degree awarded outside the U.S.), is a neuropathologist who focuses on diagnosing diseases of the brain and nervous system. He also provides autopsy pathology to help determine causes of death and anatomic pathology to examine how disease affects tissues.
As an associate professor of pathology at Yale School of Medicine, Dr. McGuone investigates how certain tumors and injuries develop in the nervous system, with the aim of improving patient care.
He received his medical training from the Royal College of Surgeons in Ireland, completed a residency in anatomic pathology at Massachusetts General Hospital, and pursued fellowships in forensic pathology at the New York City Office of the Chief Medical Examiner and neuropathology at Massachusetts General Hospital.
Titles
- Associate Professor of Pathology
Education & Training
- Fellow (Forensic Pathology)New York City Office of the Chief Medical Examiner
- Resident (Anatomic Pathology)Massachusetts General Hospital
- FellowshipMassachusetts General Hospital (2014)
- Fellow (Neuropathology)Massachusetts General Hospital
- FellowshipFrenchay Hospital (2011)
- InternshipOur Lady of Lourdes Hospital (2004)
Additional Information
Publications
- Yalcin K, Alanya H, Gultekin B, Samper Figuera D, Barak T, Miyagishima D, Youngblood M, Hjerthen M, Brooks A, Samuel Lopez N, O’Brien J, Chavez M, Dincer A, Wu H, Omay S, Yasuno K, Bilguvar K, Ercan-Sencicek A, Mishra-Gorur K, McGuone D, Moliterno J, Gunel M, Erson-Omay E. Subgroup of meningiomas involving FOS and FOSB gene fusions. Nature Communications 2025, 16: 10532. PMID: 41298363, PMCID: PMC12657970, DOI: 10.1038/s41467-025-65549-7.
- Neuschmid S, Schallerer C, Ehrlich B, McGuone D. Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration. International Journal Of Molecular Sciences 2025, 26: 9245. PMID: 41009808, PMCID: PMC12471116, DOI: 10.3390/ijms26189245.
- Schallerer C, Neuschmid S, Ehrlich B, McGuone D. Calpain in Traumatic Brain Injury: From Cinderella to Central Player. Cells 2025, 14: 1253. PMID: 40862734, PMCID: PMC12384584, DOI: 10.3390/cells14161253.
- Dincer A, Kim M, Hüseyinoglu Z, Chavez M, McGuone D, Moliterno J. Reclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case. Journal Of Neurosurgery Case Lessons 2025, 9: case24778. PMID: 40324324, PMCID: PMC12051993, DOI: 10.3171/case24778.
- Mathew S, McGuone D, Patel K, Gopal P. TDP-43 Microvasculopathy Associated Astrogliosis and Blood-Brain Barrier Breach in the Context of Alzheimer’s Disease and COVID-19. Physiology 2025, 40: 0537. DOI: 10.1152/physiol.2025.40.s1.0537.
- Leelatian N, McGuone D. Neuropathology Intraoperative Consultation. Seminars In Diagnostic Pathology 2025, 42: 150899. PMID: 40203540, DOI: 10.1016/j.semdp.2025.150899.
- Narang S, Haney S, Duhaime A, Martin J, Binenbaum G, de Alba Campomanes A, Barth R, Bertocci G, Care M, McGuone D, Laskey A, Asnes A, Brown V, Girardet R, Heavilin N, Kissoon N, McGregory K, Morgan P, Rosado N, Flaherty E, Sirotnak A, Haney S, Gavril A, Hoffert Gilmartin A, Idzerda S, Messner S, Legano L, Mohr B, Moles R, Palusci V, Nienow S, Budzak A, Suh D, Yoo S, Dumitrescu A, Fredrick D, Gise R, Strominger M, Rubin S, Karr D, Nischal K, Roarty J, Otero H, Milla S, Mercado-Deane M, Alazraki A, Annam A, Benya E, Acharya P, Brown B, Barton K, Daugherty R, Albert G, Bauer D, Ducis K, Lam S, Martin J, Rocque B, Aldana P, Brockmeyer D, Duhaime A, Jea A, Otero H, Milla S, Mercado-Deane M, Alazraki A, Annam A, Benya E, Acharya P, Brown B, Barton K, Daugherty R, Albert G, Bauer D, Ducis K, Lam S, Martin J, Rocque B, Aldana P, Brockmeyer D, Duhaime A, Jea A. Abusive Head Trauma in Infants and Children: Technical Report. 2025, 155 PMID: 39992695, DOI: 10.1542/peds.2024-070457.
- Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.
- Gupta M, Samiappan S, Alanya H, Yalcin K, Gultekin B, Sharaf R, Elsamadicy A, Figuera D, Samuel N, Mishra-Gorur K, Kolb L, McGuone D, Gunel M, Erson-Omay E, Moliterno J, Mendel E. Somatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas. Neuro-Oncology Advances 2025, 7: vdaf067. PMID: 40386121, PMCID: PMC12081948, DOI: 10.1093/noajnl/vdaf067.
- Alanya H, Yalcin K, Hilton B, Gultekin B, Mishra-Gorur K, McGuone D, Gunel M, Omay S, Erson-Omay Z. EPCO-35. GENOMIC CHARACTERIZATION OF GROWTH HORMONE SECRETING PITUITARY ADENOMAS. Neuro-Oncology 2024, 26: viii9-viii9. PMCID: PMC11553213, DOI: 10.1093/neuonc/noae165.0034.
- Mikhaiel J, Parasram M, Park J, Cappucci S, McGuone D, Falcone G, Sheth K, Gilmore E. Rocky Mountain Spotted Fever Encephalitis and “Starry Sky” Pattern on MRI. The Neurologist 2024, 30: 34-38. PMID: 39382206, DOI: 10.1097/nrl.0000000000000586.
- Kandigian S, Chande S, Dolezal D, Tang T, Wang D, Arnal-Estapé A, Cheok S, McGuone D, Liu Y, Goldberg S, Blondin N, Chiang V, Nguyen D. BSLM-10 MOLECULAR AND HISTOLOGICAL CHARACTERIZATION OF NSCLC PROGRESSION TO LEPTOMENINGEAL METASTASIS WITH COMORBID INTRAPARENCHYMAL DISEASE. Neuro-Oncology Advances 2024, 6: i7-i7. PMCID: PMC11296776, DOI: 10.1093/noajnl/vdae090.020.
- Tabor J, O'Brien J, Valero S, Pappajohn A, McGuone D, Erson-Omay Z, Yasuno K, Gunel M, Moliterno J. Heterozygous CDKN2A Loss is Associated with Recurrence and Survival in High, But Not Low Grade Meningiomas. Neurosurgery 2024, 70: 203-203. DOI: 10.1227/neu.0000000000002810_112.
- Tabor J, Dincer A, O'Brien J, Lei H, Vetsa S, Vasandani S, Jalal M, Yalcin K, Morales-Valero S, Marianayagam N, Alanya H, Elsamadicy A, Millares Chavez M, Aguilera S, Mishra-Gorur K, McGuone D, Fulbright R, Jin L, Erson-Omay E, Günel M, Moliterno J. Variations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group. Journal Of Neurosurgery 2024, 141: 664-672. PMID: 38518289, DOI: 10.3171/2024.1.jns231633.
- Leitner D, William C, Faustin A, Kanshin E, Snuderl M, McGuone D, Wisniewski T, Ueberheide B, Gould L, Devinsky O. Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history. Acta Neuropathologica 2024, 148: 76. PMID: 39607506, PMCID: PMC11604820, DOI: 10.1007/s00401-024-02832-9.
- Kapate N, Liao R, Sodemann R, Stinson T, Prakash S, Kumbhojkar N, Suja V, Wang L, Flanz M, Rajeev R, Villafuerte D, Shaha S, Janes M, Park K, Dunne M, Golemb B, Hone A, Adebowale K, Clegg J, Slate A, McGuone D, Costine-Bartell B, Mitragotri S. Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury. PNAS Nexus 2023, 3: pgad434. PMID: 38187808, PMCID: PMC10768983, DOI: 10.1093/pnasnexus/pgad434.
- Tabor J, Chavez M, O'Brien J, Morales-Valero S, Pappajohn A, McGuone D, Erson-Omay Z, Yasuno K, Gunel M, Moliterno J. EPCO-47. HETEROZYGOUS CDKN2A LOSS IS ASSOCIATED WITH HIGHER RECURRENCE AND LOWER SURVIVAL IN HIGH-, BUT NOT LOW-GRADE MENINGIOMAS. Neuro-Oncology 2023, 25: v134-v135. PMCID: PMC10639255, DOI: 10.1093/neuonc/noad179.0509.
- Mohammed F, Mcguone D, Omay S, Omay Z, Zhou J. A PILOT STUDY: SPATIOTEMPORALLY-RESOLVED MOLECULAR MECHANISMS OF ACUTE IMMUNE AND NEUROMODULATORY RESPONSES TO TRAUMATIC BRAIN INJURY. IBRO Neuroscience Reports 2023, 15: s189-s190. DOI: 10.1016/j.ibneur.2023.08.289.
- Dincer A, Jalal M, Gupte T, Vetsa S, Vasandani S, Yalcin K, Marianayagam N, Blondin N, Corbin Z, McGuone D, Fulbright R, Erson-Omay Z, Günel M, Moliterno J. The clinical and genomic features of seizures in meningiomas. Neuro-Oncology Advances 2023, 5: i49-i57. PMID: 37287582, PMCID: PMC10243847, DOI: 10.1093/noajnl/vdac110.
- Miyagishima D, Sundaresan V, Gutierrez A, Barak T, Yeung J, Moliterno J, McGuone D, Claus E, Günel M. A systematic review and individual participant data meta-analysis of gonadal steroid hormone receptors in meningioma. Journal Of Neurosurgery 2023, 139: 1638-1647. PMID: 37243565, PMCID: PMC10226381, DOI: 10.3171/2023.3.jns221838.
- Tabor J, O'Brien J, Vasandani S, Vetsa S, Lei H, Jalal M, Marianayagam N, Jin L, Millares Chavez M, Haynes J, Dincer A, Yalcin K, Aguilera S, Omay S, Mishra-Gorur K, McGuone D, Morales-Valero S, Fulbright R, Gunel M, Erson-Omay E, Moliterno J. Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas. Journal Of Neurosurgery 2023, 139: 1648-1656. PMID: 37243548, DOI: 10.3171/2023.4.jns222929.
- Galbraith K, Vasudevaraja V, Serrano J, Shen G, Tran I, Abdallat N, Wen M, Patel S, Movahed-Ezazi M, Faustin A, Spino-Keeton M, Roberts L, Maloku E, Drexler S, Liechty B, Pisapia D, Krasnozhen-Ratush O, Rosenblum M, Shroff S, Boué D, Davidson C, Mao Q, Suchi M, North P, Hopp A, Segura A, Jarzembowski J, Parsons L, Johnson M, Mobley B, Samore W, McGuone D, Gopal P, Canoll P, Horbinski C, Fullmer J, Farooqi M, Gokden M, Wadhwani N, Richardson T, Umphlett M, Tsankova N, DeWitt J, Sen C, Placantonakis D, Pacione D, Wisoff J, Hidalgo E, Harter D, William C, Cordova C, Kurz S, Barbaro M, Orringer D, Karajannis M, Sulman E, Gardner S, Zagzag D, Tsirigos A, Allen J, Golfinos J, Snuderl M. Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing. Neuro-Oncology Advances 2023, 5: vdad076. PMID: 37476329, PMCID: PMC10355794, DOI: 10.1093/noajnl/vdad076.
- Erson-Omay EZ, Vetsa S, Vasandani S, Barak T, Nadar A, Marianayagam NJ, Yalcin K, Miyagishima D, Aguilera SM, Robert S, Mishra-Gorur K, Fulbright RK, McGuone D, Günel M, Moliterno J. Genomic profiling of sporadic multiple meningiomas. BMC Medical Genomics 2022, 15: 112. PMID: 35568945, PMCID: PMC9107270, DOI: 10.1186/s12920-022-01258-0.
- Leitner DF, William C, Faustin A, Askenazi M, Kanshin E, Snuderl M, McGuone D, Wisniewski T, Ueberheide B, Gould L, Devinsky O. Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood. Acta Neuropathologica 2022, 143: 585-599. PMID: 35333953, PMCID: PMC8953962, DOI: 10.1007/s00401-022-02414-7.
- Nene A, Hong CS, McGuone D, Matouk CC, Omay SB. Staged endovascular treatment of a coexisting parasellar aneurysm and endoscopic resection of a pituitary macroadenoma: illustrative case. Journal Of Neurosurgery Case Lessons 2022, 3: case21699. PMID: 36130536, PMCID: PMC9379633, DOI: 10.3171/case21699.
- Abdelhakim S, Klapholz JD, Roy B, Weiss SA, McGuone D, Corbin ZA. Mononeuritis multiplex as a rare and severe neurological complication of immune checkpoint inhibitors: a case report. Journal Of Medical Case Reports 2022, 16: 81. PMID: 35197122, PMCID: PMC8867751, DOI: 10.1186/s13256-022-03290-1.
- Jin L, Vetsa S, Vasandani S, Nadar A, Youngblood M, Gupte T, Barak T, Yalcin K, Aguilera S, Mishra-Gorur K, Blondin N, Gorelick E, Omay S, Pointdujour-Lim R, Judson B, Alperovich M, Aboian M, Marianayagam N, McGuone D, Gunel M, Erson-Omay Z, Fulbright R, Moliterno J. TRAF7 Mutated Subgroups Differ in Sphenoid Wing Meningiomas with Hyperostosis. Journal Of Neurological Surgery Part B Skull Base 2022, 83: s1-s270. DOI: 10.1055/s-0042-1743640.
- Wang X, Habet V, Aboian M, Leelatian N, McGuone D, Morotti R, Kandil S, Darbinyan A. Neuropathology of Chiari Malformation II with Chromosome X Alterations: An Autopsy Study in a 17-Month-Old and Review of Literature. Journal Of Neuropathology & Experimental Neurology 2022, 81: 296-298. PMID: 35139536, DOI: 10.1093/jnen/nlab137.
- Jin L, Youngblood M, Gupte T, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera S, Mishra-Gorur K, Blondin N, Omay S, Pointdujour-Lim R, Judson B, Alperovich M, Aboian M, McGuone D, Gunel M, Erson-Omay Z, Fulbright R, Moliterno J. NIMG-64. TYPE OF BONY INVOLVEMENT PREDICTS GENOMIC SUBGROUP IN SPHENOID WING MENINGIOMAS. Neuro-Oncology 2021, 23: vi144-vi144. PMCID: PMC8598770, DOI: 10.1093/neuonc/noab196.562.
- Erson-Omay Z, Barak T, Vetsa S, Nadar A, Miyagishima D, Yalcin K, Aguilera S, Mishra-Gorur K, McGuone D, Fulbright R, Gunel M, Moliterno-Gunel J. EPCO-29. GENOMIC PROFILING OF SPORADIC MULTIPLE MENINGIOMAS. Neuro-Oncology 2021, 23: vi8-vi8. DOI: 10.1093/neuonc/noab196.028.
- Barak T, Vetsa S, Nadar A, Jin L, Gupte TP, Fomchenko EI, Miyagishima DF, Yalcin K, Vasandani S, Gorelick E, Zhao AY, Antonios J, Theriault BC, Lifton N, Marianayagam N, Omay B, Omay ZE, Huttner A, McGuone D, Blondin NA, Corbin Z, Fulbright RK, Moliterno J. Surgical strategies for older patients with glioblastoma. Journal Of Neuro-Oncology 2021, 155: 255-264. PMID: 34626296, PMCID: PMC8651607, DOI: 10.1007/s11060-021-03862-z.
- Johnson JE, McGuone D, Xu ML, Jane-Wit D, Mitchell RN, Libby P, Pober JS. Coronavirus Disease 2019 (COVID-19) Coronary Vascular Thrombosis Correlation with Neutrophil but Not Endothelial Activation. American Journal Of Pathology 2021, 192: 112-120. PMID: 34599881, PMCID: PMC8479934, DOI: 10.1016/j.ajpath.2021.09.004.
- Jin L, Youngblood MW, Gupte TP, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera SM, Mishra-Gorur K, Blondin NA, Gorelick E, Omay SB, Pointdujour-Lim R, Judson BL, Alperovich M, Aboian MS, McGuone D, Gunel M, Erson-Omay Z, Fulbright RK, Moliterno J. Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas. Journal Of Neuro-Oncology 2021, 154: 237-246. PMID: 34350560, DOI: 10.1007/s11060-021-03819-2.
- Brown SC, Cormier J, Tuan J, Lier AJ, McGuone D, Armstrong PM, Kaddouh F, Parikh S, Landry ML, Gobeske KT. Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 2042-2051. PMID: 34289334, PMCID: PMC8314835, DOI: 10.3201/eid2708.203730.
- Leitner DF, McGuone D, William C, Faustin A, Askenazi M, Snuderl M, Guzzetta M, Jarrell HS, Maloney K, Reichard R, Smith C, Weedn V, Wisniewski T, Gould L, Devinsky O. Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths. Neuropathology And Applied Neurobiology 2021, 48: e12746. PMID: 34164845, PMCID: PMC8777468, DOI: 10.1111/nan.12746.
- Wang Y, Iyer K, Mcguone D, Velazquez E, Maulion C. MY BLEEDING HEART: SEVERE THROMBOCYTOPENIA AND ACUTE INTRAMYOCARDIAL HEMORRHAGE. Journal Of The American College Of Cardiology 2021, 77: 2139. DOI: 10.1016/s0735-1097(21)03495-1.
- Hong CS, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Inzucchi SE, Omay SB, Erson-Omay EZ. Somatic NF1 mutations in pituitary adenomas: Report of two cases. Cancer Genetics 2021, 256: 26-30. PMID: 33862521, DOI: 10.1016/j.cancergen.2021.03.004.
- Costine-Bartell B, Price G, Shen J, McGuone D, Staley K, Duhaime AC. A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model. Neurobiology Of Disease 2021, 154: 105334. PMID: 33753291, PMCID: PMC8135256, DOI: 10.1016/j.nbd.2021.105334.
- Harowitz J, Crandall L, McGuone D, Devinsky O. Seizure‐related deaths in children: The expanding spectrum. Epilepsia 2021, 62: 570-582. PMID: 33586153, PMCID: PMC7986159, DOI: 10.1111/epi.16833.
- Hong CS, Kuzmik GA, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Blondin NA, DiLuna ML, Erson-Omay EZ. Hypermutated phenotype in gliosarcoma of the spinal cord. Npj Precision Oncology 2021, 5: 8. PMID: 33580181, PMCID: PMC7881101, DOI: 10.1038/s41698-021-00143-w.
- Hong CS, Omuro A, An Y, Inzucchi S, Kohli AA, McGuone D, Vining EM, Omay SB, Erson-Omay E. Sporadic adamantinomatous craniopharyngioma with double-hit somatic APC mutations. Neuro-Oncology Advances 2021, 3: vdab124. PMID: 34549183, PMCID: PMC8446933, DOI: 10.1093/noajnl/vdab124.
- McGuone D, Huttner A. Histopathology and Grading of Meningiomas. 2020, 11-24. DOI: 10.1007/978-3-030-59558-6_2.
- Gupte TP, Li C, Jin L, Yalcin K, Youngblood MW, Miyagishima DF, Mishra-Gorur K, Zhao AY, Antonios J, Huttner A, McGuone D, Blondin NA, Contessa JN, Zhang Y, Fulbright RK, Gunel M, Erson-Omay Z, Moliterno J. Clinical and genomic factors associated with seizures in meningiomas. Journal Of Neurosurgery 2020, 135: 835-844. PMID: 33276341, DOI: 10.3171/2020.7.jns201042.
- McGuone D, Crandall LG, Devinsky O. Sudden Unexplained Death in Childhood: A Neuropathology Review. Frontiers In Neurology 2020, 11: 582051. PMID: 33178125, PMCID: PMC7596260, DOI: 10.3389/fneur.2020.582051.
- S ., Kundishora AJ, Elsamadicy AA, Koo AB, Beckta JM, McGuone D, Erson-Omay EZ, Omay SB. Genetic characterization of a case of sellar metastasis from bronchial carcinoid neuroendocrine tumor. Surgical Neurology International 2020, 11: 303. PMID: 33093980, PMCID: PMC7568119, DOI: 10.25259/sni_265_2020.
- Hong C, McGuone D, Erson-Omay E, Omay S. 26. GENETIC CHARACTERIZATION OF SELLAR METASTASIS FROM PRIMARY BRONCHIAL CARCINOID TUMOR OF NEUROENDOCRINE PATHOLOGY. Neuro-Oncology Advances 2020, 2: ii4-ii5. PMCID: PMC7401391, DOI: 10.1093/noajnl/vdaa073.016.
- McGuone D, Sinard J, Gill JR, Masters A, Liu C, Morotti R, Parkash V. Autopsy Services and Emergency Preparedness of a Tertiary Academic Hospital Mortuary for the COVID-19 Public Health Emergency: The Yale Plan. Advances In Anatomic Pathology 2020, 27: 355-362. PMID: 32649315, DOI: 10.1097/pap.0000000000000274.
- Gummadavelli A, Dinauer C, McGuone D, Vining EM, Erson-Omay EZ, Omay SB. Large-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature. Journal Of Clinical Neuroscience 2020, 78: 420-422. PMID: 32336638, DOI: 10.1016/j.jocn.2020.04.103.
- McGuone D, Leitner D, William C, Faustin A, Leelatian N, Reichard R, Shepherd TM, Snuderl M, Crandall L, Wisniewski T, Devinsky O. Neuropathologic Changes in Sudden Unexplained Death in Childhood. Journal Of Neuropathology & Experimental Neurology 2020, 79: 336-346. PMID: 31995186, PMCID: PMC7036658, DOI: 10.1093/jnen/nlz136.
- Chen H, Thomas C, Munoz FA, Alexandrescu S, Horbinski CM, Olar A, McGuone D, Camelo-Piragua S, Wang L, Pentsova E, Phillips J, Aldape K, Chen W, Iafrate AJ, S AS, Zagzag D, Golfinos JG, Placantonakis DG, Rosenblum M, Ohman-Strickland P, Hameed M, Snuderl M. Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors. Neuro-Oncology 2019, 21: 1164-1174. PMID: 31140557, PMCID: PMC7571489, DOI: 10.1093/neuonc/noz098.
- Costine-Bartell B, McGuone D, Price G, Crawford E, Keeley K, Munoz-Pareja J, Dodge CP, Staley K, Duhaime AC. Development of a Model of Hemispheric Hypodensity (“Big Black Brain”). Journal Of Neurotrauma 2018, 36: 815-833. PMID: 30039743, PMCID: PMC6387571, DOI: 10.1089/neu.2018.5736.
- Gopal RK, Calvo SE, Shih AR, Chaves FL, McGuone D, Mick E, Pierce KA, Li Y, Garofalo A, Van Allen EM, Clish CB, Oliva E, Mootha VK. Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e6283-e6290. PMID: 29915083, PMCID: PMC6142220, DOI: 10.1073/pnas.1711888115.
- Stemmer-Rachamimov A, Laver N, McGuone D, Shah B, Weinstein G, Bedi H. Ophthalmic Diseases. 2017, 462-474. DOI: 10.1017/9781139696401.020.
- Folkerth RD, Nunez J, Georgievskaya Z, McGuone D. Neuropathologic Examination in Sudden Unexpected Deaths in Infancy and Childhood: Recommendations for Highest Diagnostic Yield and Cost-Effectiveness in Forensic Settings. Academic Forensic Pathology 2017, 7: 182-199. PMID: 31239973, PMCID: PMC6474536, DOI: 10.23907/2017.020.
- Lam JD, Oh DJ, Wong LL, Amarnani D, Park-Windhol C, Sanchez AV, Cardona-Velez J, McGuone D, Stemmer-Rachamimov AO, Eliott D, Bielenberg DR, van Zyl T, Shen L, Gai X, D'Amore PA, Kim LA, Arboleda-Velasquez JF. Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis. Diabetes 2017, 66: db161035. PMID: 28400392, PMCID: PMC5482092, DOI: 10.2337/db16-1035.
- Williams EA, McGuone D, Frosch MP, Hyman BT, Laver N, Stemmer-Rachamimov A. Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease. Journal Of Neuropathology & Experimental Neurology 2017, 76: 376-383. PMID: 28379416, PMCID: PMC7191616, DOI: 10.1093/jnen/nlx020.
- Chen H, Thomas C, Munoz F, Alexandrescu S, Horbinski C, Olar A, McGuone D, Camelo-Piragua S, Wang L, Pentsova E, Phillips J, Aldape K, Iafrate A, Golfinos J, Chi A, Zagzag D, Rosenblum M, Ohman-Strickland P, Hameed M, Snuderl M. MPTH-34. THE PROGNOSTIC VALUE OF POLYSOMY IN OLIGODENDROGLIAL TUMORS. Neuro-Oncology 2016, 18: vi113-vi113. DOI: 10.1093/neuonc/now212.471.
- Taylor SR, Smith CM, Keeley KL, McGuone D, Dodge CP, Duhaime AC, Costine BA. Neuroblast Distribution after Cortical Impact Is Influenced by White Matter Injury in the Immature Gyrencephalic Brain. Frontiers In Neuroscience 2016, 10: 387. PMID: 27601978, PMCID: PMC4994423, DOI: 10.3389/fnins.2016.00387.
- Bevers MB, McGuone D, Jerath NU, Musolino PL. Leptomeningeal transthyretin-type amyloidosis presenting as acute hydrocephalus and subarachnoid hemorrhage. Journal Of Clinical Neuroscience 2016, 29: 203-205. PMID: 26896372, DOI: 10.1016/j.jocn.2015.12.017.
- Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening. Scientific Reports 2015, 5: 16622. PMID: 26564777, PMCID: PMC4643219, DOI: 10.1038/srep16622.
- Marciscano AE, Stemmer-Rachamimov AO, Niemierko A, Larvie M, Curry WT, Barker FG, Martuza RL, McGuone D, Oh KS, Loeffler JS, Shih HA. Benign meningiomas (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes. Journal Of Neurosurgery 2015, 124: 106-14. PMID: 26274991, DOI: 10.3171/2015.1.jns142228.
- Kim LA, Wong LL, Amarnani DS, Bigger-Allen AA, Hu Y, Marko CK, Eliott D, Shah VA, McGuone D, Stemmer-Rachamimov AO, Gai X, D'Amore PA, Arboleda-Velasquez JF. Characterization of cells from patient-derived fibrovascular membranes in proliferative diabetic retinopathy. Molecular Vision 2015, 21: 673-87. PMID: 26120272, PMCID: PMC4462955.
- Shapiro KA, McGuone D, Deshpande V, Sadow PM, Stemmer-Rachamimov A, Staley KJ. Failure to detect human papillomavirus in focal cortical dysplasia type IIb. Annals Of Neurology 2015, 78: 63-67. PMID: 25893423, DOI: 10.1002/ana.24422.
- Costine BA, Missios S, Taylor SR, McGuone D, Smith CM, Dodge CP, Harris BT, Duhaime AC. The Subventricular Zone in the Immature Piglet Brain: Anatomy and Exodus of Neuroblasts into White Matter after Traumatic Brain Injury. Developmental Neuroscience 2015, 37: 115-130. PMID: 25678047, PMCID: PMC4406780, DOI: 10.1159/000369091.
- Burgin S, Stone J, Shenoy-Bhangle A, McGuone D. Case 18-2014. The New England Journal Of Medicine 2014, 370: 2327-2337. PMID: 24918376, DOI: 10.1056/nejmcpc1304161.
- Boland TA, McGuone D, Jindal J, Rocha M, Cumming M, Rupprecht CE, Barbosa TF, de Novaes Oliveira R, Chu CJ, Cole AJ, Kotait I, Kuzmina NA, Yager PA, Kuzmin IV, Hedley‐Whyte E, Brown CM, Rosenthal ES. Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies. Annals Of Neurology 2014, 75: 155-160. PMID: 24038455, PMCID: PMC4118733, DOI: 10.1002/ana.24016.
- Kay KR, Smith C, Wright AK, Serrano-Pozo A, Pooler AM, Koffie R, Bastin ME, Bak TH, Abrahams S, Kopeikina KJ, McGuone D, Frosch MP, Gillingwater TH, Hyman BT, Spires-Jones TL. Studying synapses in human brain with array tomography and electron microscopy. Nature Protocols 2013, 8: 1366-1380. PMID: 23787894, PMCID: PMC3712649, DOI: 10.1038/nprot.2013.078.
- Cole A, Eskandar E, Mela T, Noebels J, Gonzalez R, McGuone D. Case 18-2013. The New England Journal Of Medicine 2013, 368: 2304-2312. PMID: 23758236, DOI: 10.1056/nejmcpc1215969.
- McCarthy A, Farrell M, Hedley-Whyte T, McGuone D, Kavanagh E, McNally S, Keogan M, Horgan N, Lynch T, O’Rourke K. Granulomatosis with polyangiitis masquerading as giant cell arteritis. Journal Of Neurology 2013, 260: 1661-1663. PMID: 23579235, DOI: 10.1007/s00415-013-6913-3.
- Greer D, Robbins G, Lijewski V, Gonzalez R, McGuone D. Case 1-2013. The New England Journal Of Medicine 2013, 368: 172-180. PMID: 23301735, DOI: 10.1056/nejmcpc1209935.
- Kurian KM, McGuone D. Retrospective Case‐Control Study of Apolipoprotein J/Clusterin Protein Expression in Early Liveborn Neonatal Deaths with and without Pontosubicular Necrosis. Pathology Research International 2012, 2012: 479359. PMID: 22848862, PMCID: PMC3403500, DOI: 10.1155/2012/479359.
- Rice C, McGuone D, Kurian K, Love S, Renowden S, Giffin N. Autopsy-confirmed, co-existent CADASIL and multiple system atrophy. Parkinsonism & Related Disorders 2011, 17: 390-392. PMID: 21316291, DOI: 10.1016/j.parkreldis.2011.01.004.
- Mcguone D, Kay E. The impact of the organ retention controversy on the practice of hospital necropsy: a four year audit. Journal Of Clinical Pathology 2004, 57: 448. PMID: 15047757, PMCID: PMC1770284, DOI: 10.1136/jcp.2003.012633.
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