Yale Cardiology
Laboratory for Medicine and Pediatrics (LMP)
15 York Street
New Haven, CT 06510
- Yale CardiologyLaboratory for Medicine and Pediatrics (LMP)15 York StreetNew Haven, CT 06510
Daniel Greif, MD
Cardiovascular Medicine
Telehealth is available
Patient type treated
Adult
Accepting new patients
No
Referral required
Not Applicable
Board Certified in
Cardiovascular Disease and Internal Medicine
Biography
Daniel Greif, MD, treats patients with general cardiovascular diseases.
An associate professor of medicine (cardiology), his research is focused on the science of underlying cardiovascular disease, investigating the blood vessel wall in normal development and in vascular diseases. “A key component of many cardiovascular diseases is the accumulation of excess smooth muscle cells. We are uncovering the sources of these cells and the mechanisms underlying their recruitment,” he says.
Titles
- Professor of Medicine (Cardiovascular Medicine)
- Co-Director, Yale Cardiovascular Research Center (YCVRC)
Education & Training
- Post-doctoral fellowStanford University (2010)
- Clinical FellowStanford University (2007)
- HHMI Postdoctoral FellowBrigham & Women's Hospital (2003)
- Senior ResidentBrigham & Women's Hospital (2000)
- Intern, Junior ResidentUniversity of Washington (1999)
- MDUniversity of Califoria-San Francisco (1997)
- BSStanford University (1991)
Additional Information
Publications
- Saddouk F, kuzemczak A, Saito J, Greif D. Abstract 658: Endothelial And Smooth Muscle Cell Interaction In The Maintenance Of Pathological Muscularization In Pulmonary Hypertension. Arteriosclerosis Thrombosis And Vascular Biology 2023, 43 DOI: 10.1161/atvb.43.suppl_1.658.
- Kabir I, Zhang X, Dave J, Chakraborty R, Qu R, Chandran R, Ntokou A, Gallardo-Vara E, Aryal B, Rotllan N, Garcia-Milian R, Hwa J, Kluger Y, Martin K, Fernández-Hernando C, Greif D. The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques. Nature Aging 2023, 3: 64-81. PMID: 36743663, PMCID: PMC9894379, DOI: 10.1038/s43587-022-00342-5.
- Gallardo-Vara E, Ntokou A, Dave J, Jovin D, Saddouk F, Greif D. Vascular pathobiology of pulmonary hypertension. The Journal Of Heart And Lung Transplantation 2022, 42: 544-552. PMID: 36604291, PMCID: PMC10121751, DOI: 10.1016/j.healun.2022.12.012.
- Chakraborty R, Ostriker AC, Xie Y, Dave JM, Gamez-Mendez A, Chatterjee P, Abu Y, Valentine J, Lezon-Geyda K, Greif DM, Schulz VP, Gallagher PG, Sessa WC, Hwa J, Martin KA. Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity. Circulation 2022, 145: 1720-1737. PMID: 35502657, DOI: 10.1161/circulationaha.121.057599.
- Dave JM, Chakraborty R, Ntokou A, Saito J, Saddouk FZ, Feng Z, Misra A, Tellides G, Riemer RK, Urban Z, Kinnear C, Ellis J, Mital S, Mecham R, Martin KA, Greif DM. JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. Journal Of Clinical Investigation 2022, 132: e142338. PMID: 34990407, PMCID: PMC8884911, DOI: 10.1172/jci142338.
- Dave J, Saito J, Mottola G, Greif D. Chapter 8 Out to the tissues the arterial side (arteries, arterioles—development, structure, functions, and pathologies). 2022, 89-98. DOI: 10.1016/b978-0-12-822546-2.00015-0.
- Out to the tissues: the arterial side (arteries, arterioles – development, structure, functions, pathologies).Dave, JM, Saito, J, Mottola, G, Greif, DM. Invited chapter: Out to the tissues: the arterial side (arteries, arterioles – development, structure, functions, pathologies). In: Z. Gallis. The Vasculome: From Many to One. Philadelphia, PA: Elsevier Inc.; 2022, pp 89-98.
- Chandran RR, Xie Y, Gallardo-Vara E, Adams T, Garcia-Milian R, Kabir I, Sheikh AQ, Kaminski N, Martin KA, Herzog EL, Greif DM. Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis. Nature Communications 2021, 12: 7179. PMID: 34893592, PMCID: PMC8664937, DOI: 10.1038/s41467-021-27499-8.
- Kabir I, Greif D. SNCs meet SMCs in the atherosclerotic plaque. Nature Aging 2021, 1: 631-633. PMID: 36540165, PMCID: PMC9762735, DOI: 10.1038/s43587-021-00096-6.
- Kwan JM, Odanovic N, Arbune A, Higgins A, Henry M, Greif D, Foss F, Baldassarre LA. Mogamulizumab-Associated Acute Myocarditis in a Patient With T-Cell Lymphoma. JACC Case Reports 2021, 3: 1018-1023. PMID: 34317676, PMCID: PMC8311348, DOI: 10.1016/j.jaccas.2021.04.001.
- Chakraborty R, Chatterjee P, Dave JM, Ostriker AC, Greif DM, Rzucidlo EM, Martin KA. Targeting smooth muscle cell phenotypic switching in vascular disease. JVS Vascular Science 2021, 2: 79-94. PMID: 34617061, PMCID: PMC8489222, DOI: 10.1016/j.jvssci.2021.04.001.
- Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021, 6: e139067. PMID: 33591958, PMCID: PMC8026182, DOI: 10.1172/jci.insight.139067.
- Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis. Journal Of Clinical Investigation 2021, 131: e136542. PMID: 33393489, PMCID: PMC7773383, DOI: 10.1172/jci136542.
- Ntokou A, Dave J, Kauffman A, Hwa J, Herzog E, Singh I, Saltzman M, Greif D. Macrophage Platelet-Derived Growth Factor B Induces Smooth Muscle Cell Proliferation and Migration in Murine and Human Pulmonary Hypertension. 2020, a2677-a2677. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2677.
- Perry C, Gao R, Peng X, Ntokou A, Ryu C, Gomez J, Reeves B, Walia A, Sun H, Black K, Hariri L, Moore M, Gulati M, Homer R, Greif D, Eltzschig H, Herzog E. Adrenergic Nerve-Associated Lung Fibrosis Is Driven by Myeloid Netrin-1. 2020, a2410-a2410. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2410.
- Saddouk F, Ntokou A, Greif D. Specialized Smooth Muscle Cell Progenitors in Pulmonary Hypertension. 2020, 25-30. DOI: 10.1007/978-981-15-1185-1_4.
- Specialized smooth muscle cell progenitors in pulmonary hypertensionSaddouk, FZ, Ntokou, A, Greif, DM. Invited chapter: Specialized smooth muscle cell progenitors in pulmonary hypertension. In: T. Naknishi, H. Baldwin, J. Fineman, and H. Yamagishi, editors. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension. Springer Nature, 2020, pp 25-30.
- Chakraborty R, Saddouk FZ, Carrao AC, Krause DS, Greif DM, Martin KA. Promoters to Study Vascular Smooth Muscle. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 603-612. PMID: 30727757, PMCID: PMC6527360, DOI: 10.1161/atvbaha.119.312449.
- Dave JM, Mirabella T, Weatherbee SD, Greif DM. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain. Developmental Cell 2018, 47: 388-389. PMID: 30399337, PMCID: PMC6286435, DOI: 10.1016/j.devcel.2018.10.019.
- Ntokou A, Greif DM. Vagal Nerve Stimulation for Pulmonary Hypertension Some Promise, Some Skepticism ∗. JACC Basic To Translational Science 2018, 3: 672-674. PMID: 30456338, PMCID: PMC6234512, DOI: 10.1016/j.jacbts.2018.09.002.
- Dubrac A, Künzel SE, Künzel SH, Li J, Chandran RR, Martin K, Greif DM, Adams RH, Eichmann A. NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy. Nature Communications 2018, 9: 3463. PMID: 30150707, PMCID: PMC6110853, DOI: 10.1038/s41467-018-05926-7.
- Misra A, Feng Z, Chandran RR, Kabir I, Rotllan N, Aryal B, Sheikh AQ, Ding L, Qin L, Fernández-Hernando C, Tellides G, Greif DM. Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells. Nature Communications 2018, 9: 2073. PMID: 29802249, PMCID: PMC5970166, DOI: 10.1038/s41467-018-04447-7.
- Sheikh AQ, Saddouk FZ, Ntokou A, Mazurek R, Greif DM. Cell Autonomous and Non-cell Autonomous Regulation of SMC Progenitors in Pulmonary Hypertension. Cell Reports 2018, 23: 1152-1165. PMID: 29694892, PMCID: PMC5959296, DOI: 10.1016/j.celrep.2018.03.043.
- Dave JM, Mirabella T, Weatherbee SD, Greif DM. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain. Developmental Cell 2018, 44: 665-678.e6. PMID: 29456135, PMCID: PMC5871595, DOI: 10.1016/j.devcel.2018.01.018.
- Vascular embryology and angiogenesisNtokou, A, Kabir, I, Saddouk, FZ, Greif, DM. (2018). Invited chapter in: Vascular Medicine, A Companion to Braunwald’s Heart Disease, 3rd edition, editors M.A. Creager, J.A. Beckman, and J. Loscalzo, Elsevier Inc., Philadelphia, PA.
- Misra A, Feng Z, Zhang J, Lou ZY, Greif DM. Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta. Journal Of Visualized Experiments 2017 PMID: 28930997, PMCID: PMC5752224, DOI: 10.3791/56039.
- Greif DM, Eichmann A. Where do new endothelial cells come from in the injured heart? Nature Reviews Cardiology 2017, 14: 507-508. PMID: 28770866, DOI: 10.1038/nrcardio.2017.121.
- Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G. mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice. Arteriosclerosis Thrombosis And Vascular Biology 2017, 37: 1657-1666. PMID: 28751568, PMCID: PMC5574180, DOI: 10.1161/atvbaha.117.309653.
- Mazurek R, Dave JM, Chandran RR, Misra A, Sheikh AQ, Greif DM. Chapter Eight Vascular Cells in Blood Vessel Wall Development and Disease. 2016, 78: 323-350. PMID: 28212800, PMCID: PMC5559712, DOI: 10.1016/bs.apha.2016.08.001.
- Misra A, Sheikh A, Kumar A, Luo J, Zhang J, Hinton R, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif D. Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. The Journal Of General Physiology 2016, 147: 1473oia18. DOI: 10.1085/jgp.1473oia18.
- Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. Journal Of Experimental Medicine 2016, 213: 451-463. PMID: 26858344, PMCID: PMC4813675, DOI: 10.1084/jem.20150688.
- Sheikh AQ, Misra A, Rosas IO, Adams RH, Greif DM. Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Science Translational Medicine 2015, 7: 308ra159. PMID: 26446956, PMCID: PMC4629985, DOI: 10.1126/scitranslmed.aaa9712.
- Greif DM, Eichmann A. Brain vessels squeezed to death. Nature 2014, 508: 50-51. PMID: 24670635, DOI: 10.1038/nature13217.
- Sheikh AQ, Lighthouse JK, Greif DM. Recapitulation of Developing Artery Muscularization in Pulmonary Hypertension. Cell Reports 2014, 6: 809-817. PMID: 24582963, PMCID: PMC4015349, DOI: 10.1016/j.celrep.2014.01.042.
- Seidelmann SB, Lighthouse JK, Greif DM. Development and pathologies of the arterial wall. Cellular And Molecular Life Sciences 2013, 71: 1977-1999. PMID: 24071897, DOI: 10.1007/s00018-013-1478-y.
- Greif D. Chapter 1 Vascular Embryology and Angiogenesis. 2013, 1-13. DOI: 10.1016/b978-1-4377-2930-6.00001-x.
- Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nature Medicine 2012, 19: 74-82. PMID: 23263626, PMCID: PMC3540168, DOI: 10.1038/nm.3040.
- Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA. Radial Construction of an Arterial Wall. Developmental Cell 2012, 23: 482-493. PMID: 22975322, PMCID: PMC3500096, DOI: 10.1016/j.devcel.2012.07.009.
- Vascular embryology and angiogenesis.Greif, DM. (2012). Invited chapter in: Vascular Medicine, A Companion to Braunwald’s Heart Disease, 2nd edition, editors M.A. Creager, J.A. Beckman, and J. Loscalzo, Elsevier Inc., Philadelphia, PA.
- London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY. Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza. Science Translational Medicine 2010, 2: 23ra19. PMID: 20375003, PMCID: PMC2875996, DOI: 10.1126/scitranslmed.3000678.
- Dudzinski DM, Igarashi J, Greif D, Michel T. THE REGULATION AND PHARMACOLOGY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE. The Annual Review Of Pharmacology And Toxicology 2006, 46: 235-276. PMID: 16402905, DOI: 10.1146/annurev.pharmtox.44.101802.121844.
- SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK. KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation. Journal Of Experimental Medicine 2004, 199: 1305-1315. PMID: 15136591, PMCID: PMC2211816, DOI: 10.1084/jem.20031132.
- Greif DM, Sacks DB, Michel T. Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 1165-1170. PMID: 14736917, PMCID: PMC337024, DOI: 10.1073/pnas.0306377101.
- Greif DM, Kou R, Michel T. Site-Specific Dephosphorylation of Endothelial Nitric Oxide Synthase by Protein Phosphatase 2A: Evidence for Crosstalk between Phosphorylation Sites †. Biochemistry 2002, 41: 15845-15853. PMID: 12501214, DOI: 10.1021/bi026732g.
- Kou R, Greif D, Michel T. Dephosphorylation of Endothelial Nitric-oxide Synthase by Vascular Endothelial Growth Factor IMPLICATIONS FOR THE VASCULAR RESPONSES TO CYCLOSPORIN A*. Journal Of Biological Chemistry 2002, 277: 29669-29673. PMID: 12050171, DOI: 10.1074/jbc.m204519200.
- Goetz D, Greif D, Shen J, Luscinskas F. Cell-Cell Adhesive Interactions in an In Vitro Flow Chamber. 1999, 96: 137-145. PMID: 10098131, DOI: 10.1385/1-59259-258-9:137.
- Goetz D, Greif D, Ding H, Camphausen R, Howes S, Comess K, Snapp K, Kansas G, Luscinskas F. Isolated P-selectin Glycoprotein Ligand-1 Dynamic Adhesion to P- and E-selectin. Journal Of Cell Biology 1997, 137: 509-519. PMID: 9128259, PMCID: PMC2139768, DOI: 10.1083/jcb.137.2.509.
Departments and Programs
Locations
Yale Cardiology
Laboratory for Medicine and Pediatrics (LMP)
15 York Street
New Haven, CT 06510
- Yale CardiologyLaboratory for Medicine and Pediatrics (LMP)15 York StreetNew Haven, CT 06510
Biography
Daniel Greif, MD, treats patients with general cardiovascular diseases.
An associate professor of medicine (cardiology), his research is focused on the science of underlying cardiovascular disease, investigating the blood vessel wall in normal development and in vascular diseases. “A key component of many cardiovascular diseases is the accumulation of excess smooth muscle cells. We are uncovering the sources of these cells and the mechanisms underlying their recruitment,” he says.
Titles
- Professor of Medicine (Cardiovascular Medicine)
- Co-Director, Yale Cardiovascular Research Center (YCVRC)
Education & Training
- Post-doctoral fellowStanford University (2010)
- Clinical FellowStanford University (2007)
- HHMI Postdoctoral FellowBrigham & Women's Hospital (2003)
- Senior ResidentBrigham & Women's Hospital (2000)
- Intern, Junior ResidentUniversity of Washington (1999)
- MDUniversity of Califoria-San Francisco (1997)
- BSStanford University (1991)
Additional Information
Publications
- Saddouk F, kuzemczak A, Saito J, Greif D. Abstract 658: Endothelial And Smooth Muscle Cell Interaction In The Maintenance Of Pathological Muscularization In Pulmonary Hypertension. Arteriosclerosis Thrombosis And Vascular Biology 2023, 43 DOI: 10.1161/atvb.43.suppl_1.658.
- Kabir I, Zhang X, Dave J, Chakraborty R, Qu R, Chandran R, Ntokou A, Gallardo-Vara E, Aryal B, Rotllan N, Garcia-Milian R, Hwa J, Kluger Y, Martin K, Fernández-Hernando C, Greif D. The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques. Nature Aging 2023, 3: 64-81. PMID: 36743663, PMCID: PMC9894379, DOI: 10.1038/s43587-022-00342-5.
- Gallardo-Vara E, Ntokou A, Dave J, Jovin D, Saddouk F, Greif D. Vascular pathobiology of pulmonary hypertension. The Journal Of Heart And Lung Transplantation 2022, 42: 544-552. PMID: 36604291, PMCID: PMC10121751, DOI: 10.1016/j.healun.2022.12.012.
- Chakraborty R, Ostriker AC, Xie Y, Dave JM, Gamez-Mendez A, Chatterjee P, Abu Y, Valentine J, Lezon-Geyda K, Greif DM, Schulz VP, Gallagher PG, Sessa WC, Hwa J, Martin KA. Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity. Circulation 2022, 145: 1720-1737. PMID: 35502657, DOI: 10.1161/circulationaha.121.057599.
- Dave JM, Chakraborty R, Ntokou A, Saito J, Saddouk FZ, Feng Z, Misra A, Tellides G, Riemer RK, Urban Z, Kinnear C, Ellis J, Mital S, Mecham R, Martin KA, Greif DM. JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. Journal Of Clinical Investigation 2022, 132: e142338. PMID: 34990407, PMCID: PMC8884911, DOI: 10.1172/jci142338.
- Dave J, Saito J, Mottola G, Greif D. Chapter 8 Out to the tissues the arterial side (arteries, arterioles—development, structure, functions, and pathologies). 2022, 89-98. DOI: 10.1016/b978-0-12-822546-2.00015-0.
- Out to the tissues: the arterial side (arteries, arterioles – development, structure, functions, pathologies).Dave, JM, Saito, J, Mottola, G, Greif, DM. Invited chapter: Out to the tissues: the arterial side (arteries, arterioles – development, structure, functions, pathologies). In: Z. Gallis. The Vasculome: From Many to One. Philadelphia, PA: Elsevier Inc.; 2022, pp 89-98.
- Chandran RR, Xie Y, Gallardo-Vara E, Adams T, Garcia-Milian R, Kabir I, Sheikh AQ, Kaminski N, Martin KA, Herzog EL, Greif DM. Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis. Nature Communications 2021, 12: 7179. PMID: 34893592, PMCID: PMC8664937, DOI: 10.1038/s41467-021-27499-8.
- Kabir I, Greif D. SNCs meet SMCs in the atherosclerotic plaque. Nature Aging 2021, 1: 631-633. PMID: 36540165, PMCID: PMC9762735, DOI: 10.1038/s43587-021-00096-6.
- Kwan JM, Odanovic N, Arbune A, Higgins A, Henry M, Greif D, Foss F, Baldassarre LA. Mogamulizumab-Associated Acute Myocarditis in a Patient With T-Cell Lymphoma. JACC Case Reports 2021, 3: 1018-1023. PMID: 34317676, PMCID: PMC8311348, DOI: 10.1016/j.jaccas.2021.04.001.
- Chakraborty R, Chatterjee P, Dave JM, Ostriker AC, Greif DM, Rzucidlo EM, Martin KA. Targeting smooth muscle cell phenotypic switching in vascular disease. JVS Vascular Science 2021, 2: 79-94. PMID: 34617061, PMCID: PMC8489222, DOI: 10.1016/j.jvssci.2021.04.001.
- Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021, 6: e139067. PMID: 33591958, PMCID: PMC8026182, DOI: 10.1172/jci.insight.139067.
- Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis. Journal Of Clinical Investigation 2021, 131: e136542. PMID: 33393489, PMCID: PMC7773383, DOI: 10.1172/jci136542.
- Ntokou A, Dave J, Kauffman A, Hwa J, Herzog E, Singh I, Saltzman M, Greif D. Macrophage Platelet-Derived Growth Factor B Induces Smooth Muscle Cell Proliferation and Migration in Murine and Human Pulmonary Hypertension. 2020, a2677-a2677. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2677.
- Perry C, Gao R, Peng X, Ntokou A, Ryu C, Gomez J, Reeves B, Walia A, Sun H, Black K, Hariri L, Moore M, Gulati M, Homer R, Greif D, Eltzschig H, Herzog E. Adrenergic Nerve-Associated Lung Fibrosis Is Driven by Myeloid Netrin-1. 2020, a2410-a2410. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2410.
- Saddouk F, Ntokou A, Greif D. Specialized Smooth Muscle Cell Progenitors in Pulmonary Hypertension. 2020, 25-30. DOI: 10.1007/978-981-15-1185-1_4.
- Specialized smooth muscle cell progenitors in pulmonary hypertensionSaddouk, FZ, Ntokou, A, Greif, DM. Invited chapter: Specialized smooth muscle cell progenitors in pulmonary hypertension. In: T. Naknishi, H. Baldwin, J. Fineman, and H. Yamagishi, editors. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension. Springer Nature, 2020, pp 25-30.
- Chakraborty R, Saddouk FZ, Carrao AC, Krause DS, Greif DM, Martin KA. Promoters to Study Vascular Smooth Muscle. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 603-612. PMID: 30727757, PMCID: PMC6527360, DOI: 10.1161/atvbaha.119.312449.
- Dave JM, Mirabella T, Weatherbee SD, Greif DM. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain. Developmental Cell 2018, 47: 388-389. PMID: 30399337, PMCID: PMC6286435, DOI: 10.1016/j.devcel.2018.10.019.
- Ntokou A, Greif DM. Vagal Nerve Stimulation for Pulmonary Hypertension Some Promise, Some Skepticism ∗. JACC Basic To Translational Science 2018, 3: 672-674. PMID: 30456338, PMCID: PMC6234512, DOI: 10.1016/j.jacbts.2018.09.002.
- Dubrac A, Künzel SE, Künzel SH, Li J, Chandran RR, Martin K, Greif DM, Adams RH, Eichmann A. NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy. Nature Communications 2018, 9: 3463. PMID: 30150707, PMCID: PMC6110853, DOI: 10.1038/s41467-018-05926-7.
- Misra A, Feng Z, Chandran RR, Kabir I, Rotllan N, Aryal B, Sheikh AQ, Ding L, Qin L, Fernández-Hernando C, Tellides G, Greif DM. Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells. Nature Communications 2018, 9: 2073. PMID: 29802249, PMCID: PMC5970166, DOI: 10.1038/s41467-018-04447-7.
- Sheikh AQ, Saddouk FZ, Ntokou A, Mazurek R, Greif DM. Cell Autonomous and Non-cell Autonomous Regulation of SMC Progenitors in Pulmonary Hypertension. Cell Reports 2018, 23: 1152-1165. PMID: 29694892, PMCID: PMC5959296, DOI: 10.1016/j.celrep.2018.03.043.
- Dave JM, Mirabella T, Weatherbee SD, Greif DM. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain. Developmental Cell 2018, 44: 665-678.e6. PMID: 29456135, PMCID: PMC5871595, DOI: 10.1016/j.devcel.2018.01.018.
- Vascular embryology and angiogenesisNtokou, A, Kabir, I, Saddouk, FZ, Greif, DM. (2018). Invited chapter in: Vascular Medicine, A Companion to Braunwald’s Heart Disease, 3rd edition, editors M.A. Creager, J.A. Beckman, and J. Loscalzo, Elsevier Inc., Philadelphia, PA.
- Misra A, Feng Z, Zhang J, Lou ZY, Greif DM. Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta. Journal Of Visualized Experiments 2017 PMID: 28930997, PMCID: PMC5752224, DOI: 10.3791/56039.
- Greif DM, Eichmann A. Where do new endothelial cells come from in the injured heart? Nature Reviews Cardiology 2017, 14: 507-508. PMID: 28770866, DOI: 10.1038/nrcardio.2017.121.
- Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G. mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice. Arteriosclerosis Thrombosis And Vascular Biology 2017, 37: 1657-1666. PMID: 28751568, PMCID: PMC5574180, DOI: 10.1161/atvbaha.117.309653.
- Mazurek R, Dave JM, Chandran RR, Misra A, Sheikh AQ, Greif DM. Chapter Eight Vascular Cells in Blood Vessel Wall Development and Disease. 2016, 78: 323-350. PMID: 28212800, PMCID: PMC5559712, DOI: 10.1016/bs.apha.2016.08.001.
- Misra A, Sheikh A, Kumar A, Luo J, Zhang J, Hinton R, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif D. Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. The Journal Of General Physiology 2016, 147: 1473oia18. DOI: 10.1085/jgp.1473oia18.
- Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. Journal Of Experimental Medicine 2016, 213: 451-463. PMID: 26858344, PMCID: PMC4813675, DOI: 10.1084/jem.20150688.
- Sheikh AQ, Misra A, Rosas IO, Adams RH, Greif DM. Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Science Translational Medicine 2015, 7: 308ra159. PMID: 26446956, PMCID: PMC4629985, DOI: 10.1126/scitranslmed.aaa9712.
- Greif DM, Eichmann A. Brain vessels squeezed to death. Nature 2014, 508: 50-51. PMID: 24670635, DOI: 10.1038/nature13217.
- Sheikh AQ, Lighthouse JK, Greif DM. Recapitulation of Developing Artery Muscularization in Pulmonary Hypertension. Cell Reports 2014, 6: 809-817. PMID: 24582963, PMCID: PMC4015349, DOI: 10.1016/j.celrep.2014.01.042.
- Seidelmann SB, Lighthouse JK, Greif DM. Development and pathologies of the arterial wall. Cellular And Molecular Life Sciences 2013, 71: 1977-1999. PMID: 24071897, DOI: 10.1007/s00018-013-1478-y.
- Greif D. Chapter 1 Vascular Embryology and Angiogenesis. 2013, 1-13. DOI: 10.1016/b978-1-4377-2930-6.00001-x.
- Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nature Medicine 2012, 19: 74-82. PMID: 23263626, PMCID: PMC3540168, DOI: 10.1038/nm.3040.
- Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA. Radial Construction of an Arterial Wall. Developmental Cell 2012, 23: 482-493. PMID: 22975322, PMCID: PMC3500096, DOI: 10.1016/j.devcel.2012.07.009.
- Vascular embryology and angiogenesis.Greif, DM. (2012). Invited chapter in: Vascular Medicine, A Companion to Braunwald’s Heart Disease, 2nd edition, editors M.A. Creager, J.A. Beckman, and J. Loscalzo, Elsevier Inc., Philadelphia, PA.
- London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY. Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza. Science Translational Medicine 2010, 2: 23ra19. PMID: 20375003, PMCID: PMC2875996, DOI: 10.1126/scitranslmed.3000678.
- Dudzinski DM, Igarashi J, Greif D, Michel T. THE REGULATION AND PHARMACOLOGY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE. The Annual Review Of Pharmacology And Toxicology 2006, 46: 235-276. PMID: 16402905, DOI: 10.1146/annurev.pharmtox.44.101802.121844.
- SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK. KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation. Journal Of Experimental Medicine 2004, 199: 1305-1315. PMID: 15136591, PMCID: PMC2211816, DOI: 10.1084/jem.20031132.
- Greif DM, Sacks DB, Michel T. Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 1165-1170. PMID: 14736917, PMCID: PMC337024, DOI: 10.1073/pnas.0306377101.
- Greif DM, Kou R, Michel T. Site-Specific Dephosphorylation of Endothelial Nitric Oxide Synthase by Protein Phosphatase 2A: Evidence for Crosstalk between Phosphorylation Sites †. Biochemistry 2002, 41: 15845-15853. PMID: 12501214, DOI: 10.1021/bi026732g.
- Kou R, Greif D, Michel T. Dephosphorylation of Endothelial Nitric-oxide Synthase by Vascular Endothelial Growth Factor IMPLICATIONS FOR THE VASCULAR RESPONSES TO CYCLOSPORIN A*. Journal Of Biological Chemistry 2002, 277: 29669-29673. PMID: 12050171, DOI: 10.1074/jbc.m204519200.
- Goetz D, Greif D, Shen J, Luscinskas F. Cell-Cell Adhesive Interactions in an In Vitro Flow Chamber. 1999, 96: 137-145. PMID: 10098131, DOI: 10.1385/1-59259-258-9:137.
- Goetz D, Greif D, Ding H, Camphausen R, Howes S, Comess K, Snapp K, Kansas G, Luscinskas F. Isolated P-selectin Glycoprotein Ligand-1 Dynamic Adhesion to P- and E-selectin. Journal Of Cell Biology 1997, 137: 509-519. PMID: 9128259, PMCID: PMC2139768, DOI: 10.1083/jcb.137.2.509.
Departments and Programs
Locations
Yale Cardiology
Laboratory for Medicine and Pediatrics (LMP)
15 York Street
New Haven, CT 06510
- Yale CardiologyLaboratory for Medicine and Pediatrics (LMP)15 York StreetNew Haven, CT 06510
Yale Cardiology
Laboratory for Medicine and Pediatrics (LMP)
15 York Street
New Haven, CT 06510
- Yale CardiologyLaboratory for Medicine and Pediatrics (LMP)15 York StreetNew Haven, CT 06510