Daniel Greif, MD
Cardiovascular Medicine
Telehealth is available
Patient type treated
Adult
Accepting new patients
No
Referral required
Not Applicable
Biography
Daniel Greif, MD, treats patients with general cardiovascular diseases.
An associate professor of medicine (cardiology), his research is focused on the science of underlying cardiovascular disease, investigating the blood vessel wall in normal development and in vascular diseases. “A key component of many cardiovascular diseases is the accumulation of excess smooth muscle cells. We are uncovering the sources of these cells and the mechanisms underlying their recruitment,” he says.
Titles
- Associate Professor of Medicine (Cardiology)
Education & Training
- Post-doctoral fellowStanford University (2010)
- Clinical FellowStanford University (2007)
- HHMI Postdoctoral FellowBrigham & Women's Hospital (2003)
- Senior ResidentBrigham & Women's Hospital (2000)
- Intern, Junior ResidentUniversity of Washington (1999)
- MDUniversity of Califoria-San Francisco (1997)
- BSStanford University (1991)
Additional Information
Publications
- Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis. The Journal Of Clinical Investigation 2021, 131.
- Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021, 6.
- Out to the tissues: the arterial side (arteries, arterioles – development, structure, functions, pathologies).Dave, JM, Saito, J, Mottola, G, Greif, DM. Invited chapter: Out to the tissues: the arterial side (arteries, arterioles – development, structure, functions, pathologies). In: Z. Gallis. The Vasculome: From Many to One. Philadelphia, PA: Elsevier Inc.; 2020, in press.
- Chakraborty R, Saddouk FZ, Carrao AC, Krause DS, Greif DM, Martin KA. Promoters to Study Vascular Smooth Muscle. Arteriosclerosis, Thrombosis, And Vascular Biology 2019, 39:603-612.
- Vascular embryology and angiogenesisNtokou, A, Kabir, I, Saddouk, FZ, Greif, DM. (2018). Invited chapter in: Vascular Medicine, A Companion to Braunwald’s Heart Disease, 3rd edition, editors M.A. Creager, J.A. Beckman, and J. Loscalzo, Elsevier Inc., Philadelphia, PA.
- Dave JM, Mirabella T, Weatherbee SD, Greif DM. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain. Developmental Cell 2018, 44:665-678.e6.
- Sheikh AQ, Saddouk FZ, Ntokou A, Mazurek R, Greif DM. Cell Autonomous and Non-cell Autonomous Regulation of SMC Progenitors in Pulmonary Hypertension. Cell Reports 2018, 23:1152-1165.
- Misra A, Feng Z, Chandran RR, Kabir I, Rotllan N, Aryal B, Sheikh AQ, Ding L, Qin L, Fernández-Hernando C, Tellides G, Greif DM. Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells. Nature Communications 2018, 9:2073.
- Dubrac A, Künzel SE, Künzel SH, Li J, Chandran RR, Martin K, Greif DM, Adams RH, Eichmann A. NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy. Nature Communications 2018, 9:3463.
- Dave JM, Mirabella T, Weatherbee SD, Greif DM. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain. Developmental Cell 2018, 47:388-389.
- Ntokou A, Greif DM. Vagal Nerve Stimulation for Pulmonary Hypertension: Some Promise, Some Skepticism. JACC. Basic To Translational Science 2018, 3:672-674.
- Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G. mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice. Arteriosclerosis, Thrombosis, And Vascular Biology 2017, 37:1657-1666.
- Mazurek R, Dave JM, Chandran RR, Misra A, Sheikh AQ, Greif DM. Vascular Cells in Blood Vessel Wall Development and Disease. Advances In Pharmacology (San Diego, Calif.) 2017, 78:323-350.
- Greif DM, Eichmann A. Basic research: Where do new endothelial cells come from in the injured heart? Nature Reviews. Cardiology 2017, 14:507-508.
- Misra A, Feng Z, Zhang J, Lou ZY, Greif DM. Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta. Journal Of Visualized Experiments : JoVE 2017.
- Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. The Journal Of Experimental Medicine 2016, 213:451-63.
- Sheikh AQ, Misra A, Rosas IO, Adams RH, Greif DM. Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Science Translational Medicine 2015, 7:308ra159.
- Seidelmann SB, Lighthouse JK, Greif DM. Development and pathologies of the arterial wall. Cellular And Molecular Life Sciences : CMLS 2014, 71:1977-99.
- Sheikh AQ, Lighthouse JK, Greif DM. Recapitulation of developing artery muscularization in pulmonary hypertension. Cell Reports 2014, 6:809-17.
- Greif DM, Eichmann A. Vascular biology: Brain vessels squeezed to death. Nature 2014, 508:50-1.
- Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nature Medicine 2013, 19:74-82.
- Vascular embryology and angiogenesis.Greif, DM. (2012). Invited chapter in: Vascular Medicine, A Companion to Braunwald’s Heart Disease, 2nd edition, editors M.A. Creager, J.A. Beckman, and J. Loscalzo, Elsevier Inc., Philadelphia, PA.
- Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA. Radial construction of an arterial wall. Developmental Cell 2012, 23:482-93.
- London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY. Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Science Translational Medicine 2010, 2:23ra19.
- Dudzinski DM, Igarashi J, Greif D, Michel T. The regulation and pharmacology of endothelial nitric oxide synthase. Annual Review Of Pharmacology And Toxicology 2006, 46:235-76.
- Greif DM, Sacks DB, Michel T. Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101:1165-70.
- SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. The Journal Of Experimental Medicine 2004, 199:1305-15.
- Greif DM, Kou R, Michel T. Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites. Biochemistry 2002, 41:15845-53.
- Kou R, Greif D, Michel T. Dephosphorylation of endothelial nitric-oxide synthase by vascular endothelial growth factor. Implications for the vascular responses to cyclosporin A. The Journal Of Biological Chemistry 2002, 277:29669-73.
- Goetz DJ, Greif DM, Shen J, Luscinskas FW. Cell-cell adhesive interactions in an in vitro flow chamber. Methods In Molecular Biology (Clifton, N.J.) 1999, 96:137-45.
- Goetz DJ, Greif DM, Ding H, Camphausen RT, Howes S, Comess KM, Snapp KR, Kansas GS, Luscinskas FW. Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin. The Journal Of Cell Biology 1997, 137:509-19.
- Specialized smooth muscle cell progenitors in pulmonary hypertensionSaddouk, FZ, Ntokou, A, Greif, DM. Invited chapter: Specialized smooth muscle cell progenitors in pulmonary hypertension. In: T. Naknishi, H. Baldwin, J. Fineman, and H. Yamagishi, editors. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension. Springer Nature, 2020, pp 25-30.
Patient Care Organizations
- Yale CardiologyYale Physicians Building800 Howard Avenue, Ste 4th FloorNew Haven, CT, 06519
- Yale CardiologyLaboratory for Medicine and Pediatrics (LMP)15 York StreetNew Haven, CT, 06510