Clemens Scherzer, MD

Kivisäkk P, Fatima H, Wu C, Padmanabhan N, Romero D, Gorham T, Weik M, Dodge H, Scherzer C, Das S, Chibnik L, Blacker D, Gomez-Isla T, Oakley D, Frosch M, Hyman B, Demos C, Sigal G, Wohlstadter J, Serrano-Pozo A, Arnold S. Postmortem Associations Between Alzheimer Disease Pathology and Plasma pTau217, GFAP, and NfL in AD and AD-Related Dementias. Neurology 2026, 106: e214351. PMID: 41610380, PMCID: PMC12857747, DOI: 10.1212/wnl.0000000000214351.

Fiesel F, Watzlawik J, Heckman M, Blumenfeld S, Rigby M, Kehili M, Lohmann K, Klein C, Narendra D, Scherzer C, Ertekin-Taner N, Graff-Radford N, Wszolek Z, Ross O, Springer W. Phosphorylated Ubiquitin as a Clinical Biomarker for Mitochondrial Damage in Neurodegenerative Diseases. Aging And Disease 2025 PMID: 41400571, DOI: 10.14336/ad.2025.1220.

Tuominen J, Riise T, Romanowska J, Flores-Torres M, Cortese M, Scherzer C, Bjornevik K, Igland J. Association of Medication Use and 8-Year Mortality Risk in Patients With Parkinson Disease. Neurology 2025, 105: e213783. PMID: 40644656, PMCID: PMC12264975, DOI: 10.1212/wnl.0000000000213783.

Liao Y, Wu H, Wang J, Corvol J, Maple‐Grødem J, Campbell M, Elbaz A, Brice A, Schwarzschild M, Taba P, Kõks S, Beach T, Alves G, Tysnes O, Perlmutter J, Maiti B, van Hilten J, Barker R, Williams‐Gray C, Scherzer C, Liu G, Consortium I. Genetic Analysis of the X Chromosome Associates Loci with Progression of Parkinson's Disease. Movement Disorders 2025, 40: 1908-1918. PMID: 40459076, PMCID: PMC12353966, DOI: 10.1002/mds.30252.

Wang J, Chen X, Du W, Lin C, Liao Y, Corvol J, Maple-Grødem J, Campbell M, Elbaz A, Lesage S, Brice A, Schwarzschild M, Taba P, Kõks S, Alves G, Tysnes O, Perlmutter J, Maiti B, van Hilten J, Barker R, Williams-Gray C, Scherzer C, Liu G, Consortium I, Liu G, Valentino R, Liao Z, Locascio J, Corvol J, Dong X, Maple-Grødem J, Campbell M, Elbaz A, Lesage S, Brice A, Mangone G, Growdon J, Hung A, Schwarzchild M, Hayes M, Wills A, Herrington T, Ravian B, Shoulson I, Taba P, Kõks S, Beach T, Cormier-Dequaire F, Alves G, Tysnes O, Perlmutter J, Heutink P, van Hilten J, Kasten M, Mollenhauer B, Trenkwalder C, Klein C, Barker R, Williams-Gray C, Marinus J, Scherzer C. Impact of Y chromosome loss on the risk of Parkinson's disease and progression. EBioMedicine 2025, 117: 105769. PMID: 40446401, PMCID: PMC12159889, DOI: 10.1016/j.ebiom.2025.105769.

Leventhal M, Zanella C, Kang B, Peng J, Gritsch D, Liao Z, Bukhari H, Wang T, Pao P, Danquah S, Benetatos J, Nehme R, Farhi S, Tsai L, Dong X, Scherzer C, Feany M, Fraenkel E. An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration. Nature Communications 2025, 16: 4441. PMID: 40393985, PMCID: PMC12092734, DOI: 10.1038/s41467-025-59654-w.

Wu L, Real R, Martinez-Carrasco A, Chia R, Lawton M, Shoai M, Bresner C, Blauwendraat C, Singleton A, Ryten M, Abramzon Y, Ahmed S, Alba C, Albert M, Bacikova D, Barrett M, Beach T, Bennett D, Besser L, Bigio E, Boeve B, Bohannan R, Caraway C, Palma J, Chia R, Dalgard C, Dickson D, Ding J, Faber K, Ferman T, Ferrucci L, Flanagan M, Foroud T, Ghetti B, Gibbs J, Goate A, Goldstein D, Graff-Radford N, Hu H, Hupalo D, Kaiser S, Kaufmann H, Kim R, Klein G, Kukull W, Kuzma A, Leverenz J, Lopez G, Mao Q, Martinez-McGrath E, Masliah E, Monuki E, Newell K, Norcliffe-Kaufmann L, Perkins M, Pletnikova O, Renton A, Resnick S, Ross O, Sabir M, Scherzer C, Scholz S, Serrano G, Shakkotai V, Sidransky E, Singleton A, Tanaka T, Tayebi N, Traynor B, Troncoso J, Viollet C, Walton R, Woltjer R, Wszolek Z, Black S, Gan-Or Z, Keith J, Masellis M, Rogaeva E, Aarsland D, Al-Sarraj S, Attems J, Ferrari R, Gentleman S, Hardy J, Hodges A, Love S, McKeith I, Morris C, Morris H, Palmer L, Pickering-Brown S, Reynolds R, Ryten M, Thomas A, Tilley B, Troakes C, Brett F, Brice A, Duyckaerts C, Lesage S, Brunetti M, Calvo A, Canosa A, Chiò A, Floris G, Logroscino G, Zecca C, Clarimon J, Diez-Fairen M, Fortea J, González-Aramburu I, Infante J, Lage C, Lleó A, Pastor P, Porcel-Molina L, Rodríguez-Rodríguez E, Sanchez-Juan P, Krüger R, May P, Xiromerisiou G, Scholz S, Traynor B, Williams N, Hu M, Ben-Shlomo Y, Grosset D, Hardy J, Morris H. Investigation of the genetic aetiology of Lewy body diseases with and without dementia. Brain Communications 2024, 6: fcae190. PMID: 38978726, PMCID: PMC11228432, DOI: 10.1093/braincomms/fcae190.

Beaulieu-Jones B, Frau F, Bozzi S, Chandross K, Peterschmitt M, Cohen C, Coulovrat C, Kumar D, Kruger M, Lipnick S, Fitzsimmons L, Kohane I, Scherzer C. Disease progression strikingly differs in research and real-world Parkinson’s populations. Npj Parkinson's Disease 2024, 10: 58. PMID: 38480700, PMCID: PMC10937726, DOI: 10.1038/s41531-024-00667-5.

Sardi S, authors M, Giladi N, Alcalay R, Cuer G, Gasser T, Gurevich T, Höglinger G, Marek K, PaccheE C, Schapira A, Scherzer C, Simuni T, Minini P, Peterschmi M. Venglustat in GBA1-related Parkinson's disease – Authors' reply. The Lancet Neurology 2024, 23: 137-138. PMID: 38267178, DOI: 10.1016/s1474-4422(23)00470-2.

Scholz S, Moroz B, Saez-Atienzar S, Chia R, Cahoon E, Dalgard C, Dalgard C, Adeleye A, Soltis A, Alba C, Viollet C, Bacikova D, Hupalo D, Sukumar G, Pollard H, Wilkerson M, Martinez E, Black S, Gan-Or Z, Keith J, Masellis M, Rogaeva E, Brice A, Lesage S, Xiromerisiou G, Calvo A, Canosa A, Chio A, Logroscino G, Mora G, Krüger R, May P, Alcolea D, Clarimon J, Fortea J, Gonzalez-Aramburu I, Infante J, Lage C, Lleó A, Pastor P, Sanchez-Juan P, Brett F, Aarsland D, Al-Sarraj S, Attems J, Gentleman S, Hardy J, Hodges A, Love S, McKeith I, Morris C, Morris H, Palmer L, Pickering-Brown S, Ryten M, Thomas A, Troakes C, Albert M, Barrett M, Beach T, Bekris L, Bennett D, Boeve B, Dalgard C, Dawson T, Dickson D, Ferman T, Ferrucci L, Flanagan M, Foroud T, Ghetti B, Gibbs J, Goate A, Goldstein D, Graff-Radford N, Kantarci K, Kaufmann H, Kukull W, Leverenz J, Mao Q, Masliah E, Monuki E, Newell K, Palma J, Perkins M, Pletnikova O, Renton A, Resnick S, Rosenthal L, Ross O, Scherzer C, Serrano G, Shakkottai V, Sidransky E, Tanaka T, Topol E, Torkamani A, Traynor B, Troncoso J, Woltjer R, Wszolek Z, Scholz S, Freedman D, Pfeiffer R. Association of cardiovascular disease management drugs with Lewy body dementia: a case–control study. Brain Communications 2023, 6: fcad346. PMID: 38162907, PMCID: PMC10754316, DOI: 10.1093/braincomms/fcad346.

Romanowska J, Bjornevik K, Cortese M, Tuominen J, Solheim M, Abolpour Mofrad A, Igland J, Scherzer C, Riise T. Association Between Use of Any of the Drugs Prescribed in Norway and the Subsequent Risk of Parkinson Disease. Neurology 2023, 101: e2068-e2077. PMID: 37816645, PMCID: PMC10663041, DOI: 10.1212/wnl.0000000000207899.

Dong X, Bai Y, Liao Z, Gritsch D, Liu X, Wang T, Borges-Monroy R, Ehrlich A, Serrano G, Feany M, Beach T, Scherzer C. Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease. Nature Communications 2023, 14: 5327. PMID: 37723137, PMCID: PMC10507039, DOI: 10.1038/s41467-023-40348-0.

Giladi N, Alcalay R, Cutter G, Gasser T, Gurevich T, Höglinger G, Marek K, Pacchetti C, Schapira A, Scherzer C, Simuni T, Minini P, Sardi S, Peterschmitt M. Safety and efficacy of venglustat in GBA1-associated Parkinson's disease: an international, multicentre, double-blind, randomised, placebo-controlled, phase 2 trial. The Lancet Neurology 2023, 22: 661-671. PMID: 37479372, DOI: 10.1016/s1474-4422(23)00205-3.

Huh Y, Usnich T, Scherzer C, Klein C, Chung S. GBA Variants and Parkinson’s Disease: Paving the Way for Targeted Therapy. Journal Of Movement Disorders 2023, 16: 261-278. PMID: 37302978, PMCID: PMC10548077, DOI: 10.14802/jmd.23023.

Kaivola K, Chia R, Ding J, Rasheed M, Fujita M, Menon V, Walton R, Collins R, Billingsley K, Brand H, Talkowski M, Zhao X, Dewan R, Stark A, Ray A, Solaiman, Jerez P, Malik L, Dawson T, Rosenthal L, Albert M, Pletnikova O, Troncoso J, Masellis M, Keith J, Black S, Ferrucci L, Resnick S, Tanaka T, Soltis A, Viollet C, Sukumar G, Alba C, Lott N, Martinez E, Tuck M, Singh J, Bacikova D, Zhang X, Hupalo D, Adeleye A, Wilkerson M, Pollard H, Dalgard C, Black S, Gan-Or Z, Keith J, Masellis M, Rogaeva E, Brice A, Lesage S, Xiromerisiou G, Calvo A, Canosa A, Chio A, Logroscino G, Mora G, Krüger R, May P, Alcolea D, Clarimon J, Fortea J, Gonzalez-Aramburu I, Infante J, Lage C, Lleó A, Pastor P, Sanchez-Juan P, Brett F, Aarsland D, Al-Sarraj S, Attems J, Gentleman S, Hardy J, Hodges A, Love S, McKeith I, Morris C, Morris H, Palmer L, Pickering-Brown S, Ryten M, Thomas A, Troakes C, Albert M, Barrett M, Beach T, Bekris L, Bennett D, Boeve B, Dalgard C, Dawson T, Dickson D, Faber K, Ferman T, Ferrucci L, Flanagan M, Foroud T, Ghetti B, Gibbs J, Goate A, Goldstein D, Graff-Radford N, Kaufmann H, Kukull W, Leverenz J, Lopez G, Mao Q, Masliah E, Monuki E, Newell K, Palma J, Perkins M, Pletnikova O, Renton A, Resnick S, Rosenthal L, Ross O, Scherzer C, Serrano G, Shakkottai V, Sidransky E, Tanaka T, Tayebi N, Topol E, Torkamani A, Troncoso J, Woltjer R, Wszolek Z, Scholz S, Baloh R, Bowser R, Brice A, Broach J, Camu W, Chiò A, Cooper-Knock J, Drepper C, Drory V, Dunckley T, Feldman E, Fratta P, Gerhard G, Gibson S, Glass J, Hardy J, Harms M, Heiman-Patterson T, Jansson L, Kirby J, Kwan J, Laaksovirta H, Landers J, Landi F, Le Ber I, Lumbroso S, MacGowan D, Maragakis N, Mouzat K, Myllykangas L, Orrell R, Ostrow L, Pamphlett R, Pioro E, Pulst S, Ravits J, Robberecht W, Rogaeva E, Rothstein J, Sendtner M, Shaw P, Sidle K, Simmons Z, Stein T, Stone D, Tienari P, Traynor B, Troncoso J, Valori M, Van Damme P, Van Deerlin V, Van Den Bosch L, Zinman L, Consortium P, Topol E, Torkamani A, Tienari P, Foroud T, Ghetti B, Landers J, Ryten M, Morris H, Hardy J, Mazzini L, D'Alfonso S, Moglia C, Calvo A, Serrano G, Beach T, Ferman T, Graff-Radford N, Boeve B, Wszolek Z, Dickson D, Chiò A, Bennett D, De Jager P, Ross O, Dalgard C, Gibbs J, Traynor B, Scholz S. Genome-wide structural variant analysis identifies risk loci for non-Alzheimer’s dementias. Cell Genomics 2023, 3: 100316. PMID: 37388914, PMCID: PMC10300553, DOI: 10.1016/j.xgen.2023.100316.

Tuominen J, Bjørnevik K, Romanowska J, Solheim M, Grydeland T, Cortese M, Scherzer C, Riise T, Igland J. Beta2-adrenoreceptor agonists and long-term risk of Parkinson's disease. Parkinsonism & Related Disorders 2023, 110: 105389. PMID: 37027994, PMCID: PMC10387752, DOI: 10.1016/j.parkreldis.2023.105389.

Kivisäkk P, Carlyle B, Sweeney T, Trombetta B, LaCasse K, El-Mufti L, Tuncali I, Chibnik L, Das S, Scherzer C, Johnson K, Dickerson B, Gomez-Isla T, Blacker D, Oakley D, Frosch M, Hyman B, Aghvanyan A, Bathala P, Campbell C, Sigal G, Stengelin M, Arnold S. Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment. Frontiers In Neurology 2023, 14: 1069411. PMID: 36937522, PMCID: PMC10018178, DOI: 10.3389/fneur.2023.1069411.

Ndayisaba A, Pitaro A, Willett A, Jones K, de Gusmao C, Olsen A, Kim J, Rissanen E, Woods J, Srinivasan S, Nagy A, Nagy A, Mesidor M, Cicero S, Patel V, Oakley D, Tuncali I, Taglieri-Noble K, Clark E, Paulson J, Krolewski R, Ho G, Hung A, Wills A, Hayes M, Macmore J, Warren L, Bower P, Langer C, Kellerman L, Humphreys C, Glanz B, Dielubanza E, Frosch M, Freeman R, Gibbons C, Stefanova N, Chitnis T, Weiner H, Scherzer C, Scholz S, Vuzman D, Cox L, Wenning G, Schmahmann J, Gupta A, Novak P, Young G, Feany M, Singhal T, Khurana V. Correction to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenotyping. The Cerebellum 2022, 23: 52-53. PMID: 36456723, PMCID: PMC10864413, DOI: 10.1007/s12311-022-01501-5.

Liu G, Ni C, Zhan J, Li W, Luo J, Liao Z, Locascio J, Xian W, Chen L, Pei Z, Corvol J, Maple-Grødem J, Campbell M, Elbaz A, Lesage S, Brice A, Hung A, Schwarzschild M, Hayes M, Wills A, Ravina B, Shoulson I, Taba P, Kõks S, Beach T, Cormier-Dequaire F, Alves G, Tysnes O, Perlmutter J, Heutink P, van Hilten J, Barker R, Williams-Gray C, Scherzer C, Liu G, Valentino R, Peng J, Liao Z, Locascio J, Corvol J, Dong X, Maple-Grødem J, Campbell M, Elbaz A, Lesage S, Brice A, Mangone G, Growdon J, Hung A, Schwarzchild M, Hayes M, Wills A, Herrington T, Ravian B, Shoulson I, Taba P, Kõks S, Beach T, Cormier-Dequaire F, Alves G, Tysnes O, Perlmutter J, Heutink P, van Hilten J, Kasten M, Mollenhauer B, Trenkwalder C, Klein C, Barker R, Williams-Gray C, Marinus J, Scherzer C. Mitochondrial haplogroups and cognitive progression in Parkinson’s disease. Brain 2022, 146: 42-49. PMID: 36343661, PMCID: PMC10202390, DOI: 10.1093/brain/awac327.

Ndayisaba A, Pitaro A, Willett A, Jones K, de Gusmao C, Olsen A, Kim J, Rissanen E, Woods J, Srinivasan S, Nagy A, Nagy A, Mesidor M, Cicero S, Patel V, Oakley D, Tuncali I, Taglieri-Noble K, Clark E, Paulson J, Krolewski R, Ho G, Hung A, Wills A, Hayes M, Macmore J, Warren L, Bower P, Langer C, Kellerman L, Humphreys C, Glanz B, Dielubanza E, Frosch M, Freeman R, Gibbons C, Stefanova N, Chitnis T, Weiner H, Scherzer C, Scholz S, Vuzman D, Cox L, Wenning G, Schmahmann J, Gupta A, Novak P, Young G, Feany M, Singhal T, Khurana V. Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping. The Cerebellum 2022, 23: 31-51. PMID: 36190676, PMCID: PMC9527378, DOI: 10.1007/s12311-022-01471-8.

Fonseca-Ornelas L, Stricker J, Soriano-Cruz S, Weykopf B, Dettmer U, Muratore C, Scherzer C, Selkoe D. Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons. Npj Parkinson's Disease 2022, 8: 118. PMID: 36114228, PMCID: PMC9481630, DOI: 10.1038/s41531-022-00380-1.

Stoker T, Dostal V, Cochius J, Williams-Gray C, Scherzer C, Wang J, Liu G, Coyle-Gilchrist I. DCTN1 mutation associated parkinsonism: case series of three new families with perry syndrome. Journal Of Neurology 2022, 269: 6667-6672. PMID: 35895135, DOI: 10.1007/s00415-022-11308-3.

Karayel O, Winter S, Padmanabhan S, Kuras Y, Vu D, Tuncali I, Merchant K, Wills A, Scherzer C, Mann M. Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson’s disease. Cell Reports Medicine 2022, 3: 100661. PMID: 35732154, PMCID: PMC9245058, DOI: 10.1016/j.xcrm.2022.100661.

Kivisäkk P, Magdamo C, Trombetta B, Noori A, Kuo Y, Chibnik L, Carlyle B, Serrano-Pozo A, Scherzer C, Hyman B, Das S, Arnold S. Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment. Brain Communications 2022, 4: fcac155. PMID: 35800899, PMCID: PMC9257670, DOI: 10.1093/braincomms/fcac155.

Bivol S, Mellick G, Gratten J, Parker R, Mulcahy A, Mosley P, Poortvliet P, Campos A, Mitchell B, Garcia-Marin L, Cross S, Ferguson M, Lind P, Loesch D, Visscher P, Medland S, Scherzer C, Martin N, Rentería M. Australian Parkinson’s Genetics Study (APGS): pilot (n=1532). BMJ Open 2022, 12: e052032. PMID: 35217535, PMCID: PMC8883215, DOI: 10.1136/bmjopen-2021-052032.

Peterschmitt M, Saiki H, Hatano T, Gasser T, Isaacson S, Gaemers S, Minini P, Saubadu S, Sharma J, Walbillic S, Alcalay R, Cutter G, Hattori N, Höglinger G, Marek K, Schapira A, Scherzer C, Simuni T, Giladi N, Sardi S, Fischer T, Investigators O. Safety, Pharmacokinetics, and Pharmacodynamics of Oral Venglustat in Patients with Parkinson’s Disease and a GBA Mutation: Results from Part 1 of the Randomized, Double-Blinded, Placebo-Controlled MOVES-PD Trial. Journal Of Parkinson’s Disease 2022, 12: 557-570. PMID: 34897099, PMCID: PMC8925113, DOI: 10.3233/jpd-212714.

Szwedo A, Dalen I, Pedersen K, Camacho M, Bäckström D, Forsgren L, Tzoulis C, Winder‐Rhodes S, Hudson G, Liu G, Scherzer C, Lawson R, Yarnall A, Williams‐Gray C, Macleod A, Counsell C, Tysnes O, Alves G, Maple‐Grødem J, Collaboration P. GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10‐Year Population‐Based Study. Movement Disorders 2022, 37: 1016-1027. PMID: 35106798, PMCID: PMC9362732, DOI: 10.1002/mds.28932.

Huh Y, Park H, Chiang M, Tuncali I, Liu G, Locascio J, Shirvan J, Hutten S, Rotunno M, Viel C, Shihabuddin L, Wang B, Sardi S, Scherzer C. Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson’s disease enrolled in PPMI. Npj Parkinson's Disease 2021, 7: 102. PMID: 34811369, PMCID: PMC8608962, DOI: 10.1038/s41531-021-00241-3.

Kaivola K, Shah Z, Chia R, Black S, Gan-Or Z, Keith J, Masellis M, Rogaeva E, Brice A, Lesage S, Xiromerisiou G, Calvo A, Canosa A, Chio A, Logroscino G, Mora G, Krüger R, May P, Alcolea D, Clarimon J, Fortea J, Gonzalez-Aramburu I, Infante J, Lage C, Lleó A, Pastor P, Sanchez-Juan P, Brett F, Aarsland D, Al-Sarraj S, Attems J, Gentleman S, Hardy J, Hodges A, Love S, McKeith I, Morris C, Morris H, Palmer L, Pickering-Brown S, Ryten M, Thomas A, Troakes C, Albert M, Barrett M, Beach T, Bekris L, Bennett D, Boeve B, Dalgard C, Dawson T, Dickson D, Faber K, Ferman T, Ferrucci L, Flanagan M, Foroud T, Ghetti B, Gibbs J, Goate A, Goldstein D, Graff-Radford N, Kaufmann H, Kukull W, Leverenz J, Mao Q, Masliah E, Monuki E, Newell K, Palma J, Pletnikova O, Renton A, Resnick S, Rosenthal L, Ross O, Scherzer C, Serrano G, Shakkottai V, Sidransky E, Tanaka T, Topol E, Torkamani A, Troncoso J, Woltjer R, Wszolek Z, Scholz S, Scholz S. Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain 2021, 145: 1757-1762. PMID: 35381062, PMCID: PMC9423712, DOI: 10.1093/brain/awab402.

Domínguez-Baleón C, Ong J, Scherzer C, Rentería M, Dong X. Understanding the effect of smoking and drinking behavior on Parkinson's disease risk: a Mendelian randomization study. Scientific Reports 2021, 11: 13980. PMID: 34234189, PMCID: PMC8263722, DOI: 10.1038/s41598-021-93105-y.

Dong X, Li X, Chang T, Scherzer C, Weiss S, Qiu W. powerEQTL: an R package and shiny application for sample size and power calculation of bulk tissue and single-cell eQTL analysis. Bioinformatics 2021, 37: 4269-4271. PMID: 34009297, PMCID: PMC9492284, DOI: 10.1093/bioinformatics/btab385.

Iwaki H, Leonard H, Makarious M, Bookman M, Landin B, Vismer D, Casey B, Gibbs J, Hernandez D, Blauwendraat C, Vitale D, Song Y, Kumar D, Dalgard C, Sadeghi M, Dong X, Misquitta L, Scholz S, Scherzer C, Nalls M, Biswas S, Singleton A, Associates U, Group A, consortium A. Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource. Movement Disorders 2021, 36: 1795-1804. PMID: 33960523, PMCID: PMC8453903, DOI: 10.1002/mds.28549.

Liu G, Peng J, Liao Z, Locascio J, Corvol J, Zhu F, Dong X, Maple-Grødem J, Campbell M, Elbaz A, Lesage S, Brice A, Mangone G, Growdon J, Hung A, Schwarzschild M, Hayes M, Wills A, Herrington T, Ravina B, Shoulson I, Taba P, Kõks S, Beach T, Cormier-Dequaire F, Alves G, Tysnes O, Perlmutter J, Heutink P, Amr S, van Hilten J, Kasten M, Mollenhauer B, Trenkwalder C, Klein C, Barker R, Williams-Gray C, Marinus J, Scherzer C. Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson’s disease. Nature Genetics 2021, 53: 787-793. PMID: 33958783, PMCID: PMC8459648, DOI: 10.1038/s41588-021-00847-6.

Bandres-Ciga S, Saez-Atienzar S, Kim J, Makarious M, Faghri F, Diez-Fairen M, Iwaki H, Leonard H, Botia J, Ryten M, Hernandez D, Gibbs J, Ding J, Gan-Or Z, Noyce A, Pihlstrom L, Torkamani A, Soltis A, Dalgard C, Scholz S, Traynor B, Ehrlich D, Scherzer C, Bookman M, Cookson M, Blauwendraat C, Nalls M, Singleton A. Correction to: Large‑scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease. Acta Neuropathologica 2021, 142: 223-224. PMID: 33944973, PMCID: PMC8496667, DOI: 10.1007/s00401-021-02309-z.

Ortega R, Wang C, Raymond D, Bryant N, Scherzer C, Thaler A, Alcalay R, West A, Mirelman A, Kuras Y, Marder K, Giladi N, Ozelius L, Bressman S, Saunders-Pullman R. Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression. JAMA Network Open 2021, 4: e215845. PMID: 33881531, PMCID: PMC8060834, DOI: 10.1001/jamanetworkopen.2021.5845.

Tokarew J, El-Kodsi D, Lengacher N, Fehr T, Nguyen A, Shutinoski B, O’Nuallain B, Jin M, Khan J, Ng A, Li J, Jiang Q, Zhang M, Wang L, Sengupta R, Barber K, Tran A, Im D, Callaghan S, Park D, Zandee S, Dong X, Scherzer C, Prat A, Tsai E, Takanashi M, Hattori N, Chan J, Zecca L, West A, Holmgren A, Puente L, Shaw G, Toth G, Woulfe J, Taylor P, Tomlinson J, Schlossmacher M. Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites. Acta Neuropathologica 2021, 141: 725-754. PMID: 33694021, PMCID: PMC8043881, DOI: 10.1007/s00401-021-02285-4.

Chia R, Sabir M, Bandres-Ciga S, Saez-Atienzar S, Reynolds R, Gustavsson E, Walton R, Ahmed S, Viollet C, Ding J, Makarious M, Diez-Fairen M, Portley M, Shah Z, Abramzon Y, Hernandez D, Blauwendraat C, Stone D, Eicher J, Parkkinen L, Ansorge O, Clark L, Honig L, Marder K, Lemstra A, St George-Hyslop P, Londos E, Morgan K, Lashley T, Warner T, Jaunmuktane Z, Galasko D, Santana I, Tienari P, Myllykangas L, Oinas M, Cairns N, Morris J, Halliday G, Van Deerlin V, Trojanowski J, Grassano M, Calvo A, Mora G, Canosa A, Floris G, Bohannan R, Brett F, Gan-Or Z, Geiger J, Moore A, May P, Krüger R, Goldstein D, Lopez G, Tayebi N, Sidransky E, Norcliffe-Kaufmann L, Palma J, Kaufmann H, Shakkottai V, Perkins M, Newell K, Gasser T, Schulte C, Landi F, Salvi E, Cusi D, Masliah E, Kim R, Caraway C, Monuki E, Brunetti M, Dawson T, Rosenthal L, Albert M, Pletnikova O, Troncoso J, Flanagan M, Mao Q, Bigio E, Rodríguez-Rodríguez E, Infante J, Lage C, González-Aramburu I, Sanchez-Juan P, Ghetti B, Keith J, Black S, Masellis M, Rogaeva E, Duyckaerts C, Brice A, Lesage S, Xiromerisiou G, Barrett M, Tilley B, Gentleman S, Logroscino G, Serrano G, Beach T, McKeith I, Thomas A, Attems J, Morris C, Palmer L, Love S, Troakes C, Al-Sarraj S, Hodges A, Aarsland D, Klein G, Kaiser S, Woltjer R, Pastor P, Bekris L, Leverenz J, Besser L, Kuzma A, Renton A, Goate A, Bennett D, Scherzer C, Morris H, Ferrari R, Albani D, Pickering-Brown S, Faber K, Kukull W, Morenas-Rodriguez E, Lleó A, Fortea J, Alcolea D, Clarimon J, Nalls M, Ferrucci L, Resnick S, Tanaka T, Foroud T, Graff-Radford N, Wszolek Z, Ferman T, Boeve B, Hardy J, Topol E, Torkamani A, Singleton A, Ryten M, Dickson D, Chiò A, Ross O, Gibbs J, Dalgard C, Traynor B, Scholz S. Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nature Genetics 2021, 53: 294-303. PMID: 33589841, PMCID: PMC7946812, DOI: 10.1038/s41588-021-00785-3.

Lerche S, Schulte C, Wurster I, Machetanz G, Roeben B, Zimmermann M, Deuschle C, Hauser A, Böhringer J, Krägeloh‐Mann I, Waniek K, Lachmann I, Petterson X, Chiang R, Park H, Wang B, Liepelt‐Scarfone I, Maetzler W, Galasko D, Scherzer C, Gasser T, Mielke M, Hutten S, Mollenhauer B, Sardi S, Berg D, Brockmann K. The Mutation Matters: CSF Profiles of GCase, Sphingolipids, α‐Synuclein in PDGBA. Movement Disorders 2021, 36: 1216-1228. PMID: 33547828, DOI: 10.1002/mds.28472.

Anderson F, von Herrmann K, Andrew A, Kuras Y, Young A, Scherzer C, Hickey W, Lee S, Havrda M. Plasma-borne indicators of inflammasome activity in Parkinson’s disease patients. Npj Parkinson's Disease 2021, 7: 2. PMID: 33398042, PMCID: PMC7782812, DOI: 10.1038/s41531-020-00147-6.

Nasamran C, Sachan A, Mott J, Kuras Y, Scherzer C, Study H, Ricciardelli E, Jepsen K, Edland S, Fisch K, Desplats P. Differential blood DNA methylation across Lewy body dementias. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2021, 13: e12156. PMID: 33665346, PMCID: PMC7896631, DOI: 10.1002/dad2.12156.

Lohr K, Frost B, Scherzer C, Feany M. Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 33608-33618. PMID: 33318181, PMCID: PMC7777082, DOI: 10.1073/pnas.1922392117.

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Watzlawik J, Hou X, Fricova D, Ramnarine C, Barodia S, Gendron T, Heckman M, DeTure M, Siuda J, Wszolek Z, Scherzer C, Ross O, Bu G, Dickson D, Goldberg M, Fiesel F, Springer W. Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples. Autophagy 2020, 17: 2613-2628. PMID: 33112198, PMCID: PMC8496550, DOI: 10.1080/15548627.2020.1834712.

Iwaki H, Blauwendraat C, Leonard H, Makarious M, Kim J, Liu G, Maple‐Grødem J, Corvol J, Pihlstrøm L, van Nimwegen M, Smolensky L, Amondikar N, Hutten S, Frasier M, Nguyen K, Rick J, Eberly S, Faghri F, Auinger P, Scott K, Wijeyekoon R, Van Deerlin V, Hernandez D, Gibbs R, Day‐Williams A, Brice A, Alves G, Noyce A, Tysnes O, Evans J, Breen D, Estrada K, Wegel C, Danjou F, Simon D, Andreassen O, Ravina B, Toft M, Heutink P, Bloem B, Weintraub D, Barker R, Williams‐Gray C, van de Warrenburg B, Van Hilten J, Scherzer C, Singleton A, Nalls M. Differences in the Presentation and Progression of Parkinson's Disease by Sex. Movement Disorders 2020, 36: 106-117. PMID: 33002231, PMCID: PMC7883324, DOI: 10.1002/mds.28312.

Alcalay R, Wolf P, Chiang M, Helesicova K, Zhang X, Merchant K, Hutten S, Scherzer C, Caspell‐Garcia C, Blauwendraat C, Foroud T, Nudelman K, Gan‐Or Z, Simuni T, Chahine L, Levy O, Zheng D, Li G, Sardi S, Marek K, Siderowf A, Seibyl J, Coffey C, Tanner C, Tosun‐Turgut D, Shaw L, Trojanowski J, Singleton A, Kieburtz K, Toga A, Mollenhauer B, Galasko D, Chahine L, Poewe W, Poston K, Bressman S, Reimer A, Arnedo V, Clark A, Frasier M, Kopil C, Chowdhury S, Sherer T, Casaceli C, Dorsey R, Wilson R, Mahes S, Salerno C, Crawford K, Casalin P, Malferrari G, Weisz M, Orr‐Urtreger A, Montine T, Baglieri C, Christini A, Russell D, Dahodwala N, Giladi N, Factor S, Hogarth P, Standaert D, Hauser R, Jankovic J, Saint‐Hilaire M, Richard I, Shprecher D, Fernandez H, Brockmann K, Rosenthal L, Barone P, Espay A, Rowe D, Marder K, Santiago A, Hu S, Isaacson S, Martinez J, Tolosa E, Tai Y, Politis M, Smejdir D, Rees L, Williams K, Kausar F, Richardson W, Willeke D, Peacock S, Sommerfeld B, Freed A, Wakeman K, Blair C, Guthrie S, Harrell L, Hunter C, Thomas C, James R, Zimmerman G, Brown V, Mule J, Hilt E, Ribb K, Ainscough S, Wethington M, Ranola M, Mejia Santana H, Moreno J, Raymond D, Speketer K, Carvajal L, Carvalo S, Croitoru I, Garrido A, Payne L, Viswanth V, Severt L, Facheris M, Soares H, Mintun M, Cedarbaum J, Taylor P, Biglan K, Vandenbroucke E, Haider Sheikh Z, Bingol B, Fischer T, Sardi P, Forrat R, Reith A, Egebjerg J, Hillert G, Saba B, Min C, Umek R, Mather J, De Santi S, Post A, Boess F, Taylor K, Grachev I, Avbersek A, Muglia P, Merchant K, Tauscher J. Longitudinal Measurements of Glucocerebrosidase activity in Parkinson’s patients. Annals Of Clinical And Translational Neurology 2020, 7: 1816-1830. PMID: 32888397, PMCID: PMC7545591, DOI: 10.1002/acn3.51164.

Bandres-Ciga S, Saez-Atienzar S, Kim J, Makarious M, Faghri F, Diez-Fairen M, Iwaki H, Leonard H, Botia J, Ryten M, Hernandez D, Gibbs J, Ding J, Gan-Or Z, Noyce A, Pihlstrom L, Torkamani A, Soltis A, Dalgard C, Scholz S, Traynor B, Ehrlich D, Scherzer C, Bookman M, Cookson M, Blauwendraat C, Nalls M, Singleton A. Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease. Acta Neuropathologica 2020, 140: 341-358. PMID: 32601912, PMCID: PMC8096770, DOI: 10.1007/s00401-020-02181-3.

Huh Y, Chiang M, Locascio J, Liao Z, Liu G, Choudhury K, Kuras Y, Tuncali I, Videnovic A, Hunt A, Schwarzschild M, Hung A, Herrington T, Hayes M, Hyman B, Wills A, Gomperts S, Growdon J, Sardi S, Scherzer C. β-Glucocerebrosidase activity in GBA-linked Parkinson disease: The type of mutation matters. Neurology 2020, 95: e685-e696. PMID: 32540937, PMCID: PMC7455354, DOI: 10.1212/wnl.0000000000009989.

Scherzer C, Riise T, Locascio J. Reader response: Use of β2-adrenoreceptor agonist and antagonist drugs and risk of Parkinson disease. Neurology 2020, 94: 898-899. PMID: 32423986, DOI: 10.1212/wnl.0000000000009449.

Ihle J, Artaud F, Bekadar S, Mangone G, Sambin S, Mariani L, Bertrand H, Rascol O, Durif F, Derkinderen P, Scherzer C, Elbaz A, Corvol J, group D, committee S, Corvol J, Elbaz A, Vidailhet M, Brice A, analyses S, Artaud F, sites I, Bourdain F, Brandel J, Derkinderen P, Durif F, Levy R, Pico F, Rascol O, Co-investigators, Bonnet A, Bonnet C, Brefel-Courbon C, Cormier-Dequaire F, Degos B, Debilly B, Elbaz A, Galitsky M, Grabli D, Hartmann A, Klebe S, Kraemmer J, Lacomblez L, Leder S, Mangone G, Mariani L, Marques A, Mesnage V, Muellner J, Ory-Magne F, Planté-Bordeneuve V, Roze E, Tir M, You H, Neuropsychologists, Benchetrit E, Socha J, Pineau F, Vidal T, Pomies E, Bayet V, core G, Lesage S, Tahiri K, Bertrand H, assistants S, Mallet A, Villeret C, Mazmanian M, Manseur H, Hajji M, Le Toullec B, Brochard V, Roy M, Rieu I, Bernard S, Faurie-Grepon A. Parkinson's disease polygenic risk score is not associated with impulse control disorders: A longitudinal study. Parkinsonism & Related Disorders 2020, 75: 30-33. PMID: 32450545, DOI: 10.1016/j.parkreldis.2020.03.017.

Stoker T, Camacho M, Winder-Rhodes S, Liu G, Scherzer C, Foltynie T, Evans J, Breen D, Barker R, Williams-Gray C. Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson’s disease. Journal Of Neurology Neurosurgery & Psychiatry 2020, 91: 695-702. PMID: 32303560, PMCID: PMC7361014, DOI: 10.1136/jnnp-2020-322857.

Bakshi R, Macklin E, Hung A, Hayes M, Hyman B, Wills A, Gomperts S, Growdon J, Ascherio A, Scherzer C, Schwarzschild M. Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson’s Disease in the Harvard Biomarkers Study. Journal Of Parkinson’s Disease 2020, 10: 505-510. PMID: 32250320, PMCID: PMC7416447, DOI: 10.3233/jpd-191882.

Stoker T, Camacho M, Winder-Rhodes S, Liu G, Scherzer C, Foltynie T, Barker R, Williams-Gray C. A common polymorphism in SNCA is associated with accelerated motor decline in GBA-Parkinson’s disease. Journal Of Neurology Neurosurgery & Psychiatry 2020, 91: 673-674. PMID: 32241921, PMCID: PMC7279193, DOI: 10.1136/jnnp-2019-322210.

Rotunno M, Lane M, Zhang W, Wolf P, Oliva P, Viel C, Wills A, Alcalay R, Scherzer C, Shihabuddin L, Zhang K, Sardi S. Cerebrospinal fluid proteomics implicates the granin family in Parkinson’s disease. Scientific Reports 2020, 10: 2479. PMID: 32051502, PMCID: PMC7015906, DOI: 10.1038/s41598-020-59414-4.

Iwaki H, Blauwendraat C, Leonard H, Kim J, Liu G, Maple‐Grødem J, Corvol J, Pihlstrøm L, van Nimwegen M, Hutten S, Nguyen K, Rick J, Eberly S, Faghri F, Auinger P, Scott K, Wijeyekoon R, Van Deerlin V, Hernandez D, Gibbs J, Consortium I, Chitrala K, Day‐Williams A, Brice A, Alves G, Noyce A, Tysnes O, Evans J, Breen D, Estrada K, Wegel C, Danjou F, Simon D, Andreassen O, Ravina B, Toft M, Heutink P, Bloem B, Weintraub D, Barker R, Williams‐Gray C, van de Warrenburg B, Van Hilten J, Scherzer C, Singleton A, Nalls M. Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts. Movement Disorders 2019, 34: 1839-1850. PMID: 31505070, PMCID: PMC7017876, DOI: 10.1002/mds.27845.

Iwaki H, Blauwendraat C, Leonard H, Liu G, Maple-Grødem J, Corvol J, Pihlstrøm L, van Nimwegen M, Hutten S, Nguyen K, Rick J, Eberly S, Faghri F, Auinger P, Scott K, Wijeyekoon R, Van Deerlin V, Hernandez D, Day-Williams A, Brice A, Alves G, Noyce A, Tysnes O, Evans J, Breen D, Estrada K, Wegel C, Danjou F, Simon D, Ravina B, Toft M, Heutink P, Bloem B, Weintraub D, Barker R, Williams-Gray C, van de Warrenburg B, Van Hilten J, Scherzer C, Singleton A, Nalls M. Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts. Neurology Genetics 2019, 5: e348. PMID: 31404238, PMCID: PMC6659137, DOI: 10.1212/nxg.0000000000000348.

O'Bryant S, Edwards M, Zhang F, Johnson L, Hall J, Kuras Y, Scherzer C. Potential two‐step proteomic signature for Parkinson's disease: Pilot analysis in the Harvard Biomarkers Study. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2019, 11: 374-382. PMID: 31080873, PMCID: PMC6502745, DOI: 10.1016/j.dadm.2019.03.001.

Henderson-Smith A, Fisch K, Hua J, Liu G, Ricciardelli E, Jepsen K, Huentelman M, Stalberg G, Edland S, Scherzer C, Dunckley T, Desplats P. DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood. Epigenetics 2019, 14: 365-382. PMID: 30871403, PMCID: PMC6557551, DOI: 10.1080/15592294.2019.1588682.

Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio J, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler C, Hedreen J, Faull R, Frosch M, Nelson P, Rizzu P, Cooper A, Heutink P, Beach T, Mattick J, Müller F, Scherzer C. Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Nature Neuroscience 2018, 22: 144-147. PMID: 30482917, DOI: 10.1038/s41593-018-0277-z.

Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio J, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler C, Hedreen J, Faull R, Frosch M, Nelson P, Rizzu P, Cooper A, Heutink P, Beach T, Mattick J, Müller F, Scherzer C. Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Nature Neuroscience 2018, 21: 1482-1492. PMID: 30224808, PMCID: PMC6334654, DOI: 10.1038/s41593-018-0223-0.

Chen-Plotkin AS, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D, Buko A, Cedarbaum J, Chelsky D, Cookson MR, Dawson TM, Dewey R, Foroud T, Frasier M, German D, Gwinn K, Huang X, Kopil C, Kremer T, Lasch S, Marek K, Marto JA, Merchant K, Mollenhauer B, Naito A, Potashkin J, Reimer A, Rosenthal LS, Saunders-Pullman R, Scherzer CR, Sherer T, Singleton A, Sutherland M, Thiele I, van der Brug M, Van Keuren-Jensen K, Vaillancourt D, Walt D, West A, Zhang J. Finding useful biomarkers for Parkinson’s disease. Science Translational Medicine 2018, 10 PMID: 30111645, PMCID: PMC6097233, DOI: 10.1126/scitranslmed.aam6003.

Olsen A, Riise T, Scherzer C. Discovering New Benefits From Old Drugs With Big Data—Promise for Parkinson Disease. JAMA Neurology 2018, 75: 917-920. PMID: 29710184, DOI: 10.1001/jamaneurol.2018.0345.

Mittal S, Bjørnevik K, Im D, Flierl A, Dong X, Locascio J, Abo K, Long E, Jin M, Xu B, Xiang Y, Rochet J, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe D, Caldarone B, Glicksman M, Khurana V, Schüle B, Park D, Riise T, Scherzer C. β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease. Science 2017, 357: 891-898. PMID: 28860381, PMCID: PMC5761666, DOI: 10.1126/science.aaf3934.

Liu G, Locascio J, Corvol J, Boot B, Liao Z, Page K, Franco D, Burke K, Jansen I, Trisini-Lipsanopoulos A, Winder-Rhodes S, Tanner C, Lang A, Eberly S, Elbaz A, Brice A, Mangone G, Ravina B, Shoulson I, Cormier-Dequaire F, Heutink P, van Hilten J, Barker R, Williams-Gray C, Marinus J, Scherzer C, Scherzer C, Hyman B, Ivinson A, Trisini-Lipsanopoulos A, Franco D, Burke K, Sudarsky L, Hayes M, Umeh C, Sperling R, Growdon J, Schwarzschild M, Hung A, Flaherty A, Blacker D, Wills A, Sohur U, Mejia N, Viswanathan A, Gomperts S, Khurana V, Albers M, Alora-Palli M, McGinnis S, Sharma N, Dickerson B, Frosch M, Gomez-Isla T, Greenberg S, Gusella J, Hedden T, Hedley-Whyte E, Koenig A, Marquis-Sayagues M, Marshall G, Okereke O, Stemmer-Rachaminov A, Kloppenburg J, Schlossmacher M, Growdon J, Selkoe D, Sperling R, Yi T, Locascio J, Li H, Stalberg G, Liao Z, Barker R, Foltynie T, Williams-Gray C, Robbins T, Brayne C, Mason S, Winder-Rhodes S, Barker R, Williams-Gray C, Breen D, Cummins G, Evans J, Winder-Rhodes S, van Hilten J, Marinus J, Corvol J, Brice A, Corvol J, Elbaz A, Mallet A, Vidailhet M, Bonnet A, Bonnet C, Corvol J, Elbaz A, Grabli D, Hartmann A, Klebe S, Lacomblez L, Mangone G, Vidailhet M, Bourdain F, Brandel J, Derkinderen P, Durif F, Mesnage V, Pico F, Rascol O, Brefel-Courbon C, Ory-Magne F, Forlani S, Lesage S, Mangone G, Tahiri K, Albin R, Alcalay R, Ascherio A, Bowman D, Chen-Plotkin A, Dawson T, Dewey R, German D, Saunders-Pullman R, Scherzer C, Vaillancourt D, Petyuk V, West A, Zhang J. Prediction of cognition in Parkinson's disease with a clinical–genetic score: a longitudinal analysis of nine cohorts. The Lancet Neurology 2017, 16: 620-629. PMID: 28629879, PMCID: PMC5761650, DOI: 10.1016/s1474-4422(17)30122-9.

Gwinn K, David K, Swanson-Fischer C, Albin R, St Hillaire-Clarke C, Sieber B, Lungu C, Bowman F, Alcalay R, Babcock D, Dawson T, Dewey R, Foroud T, German D, Huang X, Petyuk V, Potashkin J, Saunders-Pullman R, Sutherland M, Walt D, West A, Zhang J, Chen-Plotkin A, Scherzer C, Vaillancourt D, Rosenthal L. Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program. Biomarkers In Medicine 2017, 11: 451-473. PMID: 28644039, PMCID: PMC5619098, DOI: 10.2217/bmm-2016-0370.

Manocha G, Floden A, Puig K, Nagamoto-Combs K, Scherzer C, Combs C. Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice. Molecular Neurodegeneration 2017, 12: 17. PMID: 28196514, PMCID: PMC5310074, DOI: 10.1186/s13024-017-0158-z.

Liu G, Boot B, Locascio J, Jansen I, Winder‐Rhodes S, Eberly S, Elbaz A, Brice A, Ravina B, van Hilten J, Cormier‐Dequaire F, Corvol J, Barker R, Heutink P, Marinus J, Williams‐Gray C, Scherzer C, Scherzer C, Hyman B, Ivinson A, Trisini‐Lipsanopoulos A, Franco D, Burke K, Sudarsky L, Hayes M, Umeh C, Growdon J, Schwarzschild M, Hung A, Flaherty A, Wills A, Mejia N, Gomperts S, Khurana V, Selkoe D, Yi T, Page K, Liao Z, Barker R, Foltynie T, Williams‐Gray C, Mason S, Winder‐Rhodes S, Barker R, Williams‐Gray C, Breen D, Cummins G, Evans J, Winder‐Rhodes S, Corvol J, Brice A, Elbaz A, Mallet A, Vidailhet M, Bonnet A, Bonnet C, Grabli D, Hartmann A, Klebe S, Lacomblez L, Mangone G, Bourdain F, Brandel J, Derkinderen P, Durif F, Mesnage V, Pico F, Rascol O, Forlani S, Lesage S, Tahiri K, van Hilten J, Marinus J, Liao Z, Page K, Franco D, Duong K, Yi T, Trisini‐Lipsanopoulos A, Dong X, Sudarsky L, Hutten S, Amr S, Shoulson I, Tanner C, Lang A, Nalls M. Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's. Annals Of Neurology 2016, 80: 674-685. PMID: 27717005, PMCID: PMC5244667, DOI: 10.1002/ana.24781.

Takeda S, Commins C, DeVos S, Nobuhara C, Wegmann S, Roe A, Costantino I, Fan Z, Nicholls S, Sherman A, Lipsanopoulos A, Scherzer C, Carlson G, Pitstick R, Peskind E, Raskind M, Li G, Montine T, Frosch M, Hyman B. Seed‐competent high‐molecular‐weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Annals Of Neurology 2016, 80: 355-367. PMID: 27351289, PMCID: PMC5016222, DOI: 10.1002/ana.24716.

Chhatwal J, Schultz A, Marshall G, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe A, Hyman B, Sperling R, Johnson K. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology 2016, 87: 920-926. PMID: 27473132, PMCID: PMC5035159, DOI: 10.1212/wnl.0000000000003050.

Hill-Burns E, Ross O, Wissemann W, Soto-Ortolaza A, Zareparsi S, Siuda J, Lynch T, Wszolek Z, Silburn P, Mellick G, Ritz B, Scherzer C, Zabetian C, Factor S, Breheny P, Payami H. Identification of genetic modifiers of age-at-onset for familial Parkinson’s disease. Human Molecular Genetics 2016, 25: 3849-3862. PMID: 27402877, PMCID: PMC5216611, DOI: 10.1093/hmg/ddw206.

Lööv C, Scherzer C, Hyman B, Breakefield X, Ingelsson M. α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities. Cellular And Molecular Neurobiology 2016, 36: 437-448. PMID: 26993503, PMCID: PMC11482338, DOI: 10.1007/s10571-015-0317-0.

Bakshi R, Mittal S, Liao Z, Scherzer C. A Feed‐Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain. Parkinson's Disease 2016, 2016: 2405176. PMID: 27088034, PMCID: PMC4818948, DOI: 10.1155/2016/2405176.

Rosenthal L, Drake D, Alcalay R, Babcock D, Bowman F, Chen‐Plotkin A, Dawson T, Dewey R, German D, Huang X, Landin B, McAuliffe M, Petyuk V, Scherzer C, St. Hillaire‐Clarke C, Sieber B, Sutherland M, Tarn C, West A, Vaillancourt D, Zhang J, Gwinn K, consortium O. The NINDS Parkinson's disease biomarkers program. Movement Disorders 2015, 31: 915-923. PMID: 26442452, PMCID: PMC4824671, DOI: 10.1002/mds.26438.

Sorond F, Cruz-Almeida Y, Clark D, Viswanathan A, Scherzer C, De Jager P, Csiszar A, Laurienti P, Hausdorff J, Chen W, Ferrucci L, Rosano C, Studenski S, Black S, Lipsitz L. Aging, the Central Nervous System, and Mobility in Older Adults: Neural Mechanisms of Mobility Impairment. The Journals Of Gerontology Series A 2015, 70: 1526-1532. PMID: 26386013, PMCID: PMC4643615, DOI: 10.1093/gerona/glv130.

Locascio J, Eberly S, Liao Z, Liu G, Hoesing A, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung A, Flaherty A, Schwarzschild M, Hayes M, Wills A, Sohur U, Mejia N, Selkoe D, Oakes D, Shoulson I, Dong X, Marek K, Zheng B, Ivinson A, Hyman B, Growdon J, Sudarsky L, Schlossmacher M, Ravina B, Scherzer C. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease. Brain 2015, 138: 2659-2671. PMID: 26220939, PMCID: PMC4643625, DOI: 10.1093/brain/awv202.

Chhatwal J, Schultz A, Marshall G, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe A, Hyman B, Sperling R, Johnson K. O4‐01‐04: Entorhinal, parahippocampal, and inferior temporal F18‐T807 SUVR correlates with CSF total tau and tau T181P in cognitively normal elderly. Alzheimer's & Dementia 2015, 11: p267-p267. DOI: 10.1016/j.jalz.2015.07.348.

Chhatwal J, Schultz A, Marshall G, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe A, Hyman B, Sperling R, Johnson K. IC‐P‐162: Entorhinal, parahippocampal, and inferior temporal F18‐T807 SUVR correlates with CSF total tau and tau T181P in cognitively normal elderly. Alzheimer's & Dementia 2015, 11: p109-p109. DOI: 10.1016/j.jalz.2015.06.185.

Doss S, Wandinger K, Hyman B, Panzer J, Synofzik M, Dickerson B, Mollenhauer B, Scherzer C, Ivinson A, Finke C, Schöls L, vom Hagen J, Trenkwalder C, Jahn H, Höltje M, Biswal B, Harms L, Ruprecht K, Buchert R, Höglinger G, Oertel W, Unger M, Körtvélyessy P, Bittner D, Priller J, Spruth E, Paul F, Meisel A, Lynch D, Dirnagl U, Endres M, Teegen B, Probst C, Komorowski L, Stöcker W, Dalmau J, Prüss H. High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types. Annals Of Clinical And Translational Neurology 2014, 1: 822-832. PMID: 25493273, PMCID: PMC4241809, DOI: 10.1002/acn3.120.

Santiago J, Scherzer C, Potashkin J. Network Analysis Identifies SOD2 mRNA as a Potential Biomarker for Parkinson's Disease. PLOS ONE 2014, 9: e109042. PMID: 25279756, PMCID: PMC4184821, DOI: 10.1371/journal.pone.0109042.

Ward M, Hyman B, Scherzer C, Trisini‐Lipsanopoulos A, Ivinson A, Lößner C, Farztdinov V, Lovestone S, Pike I. P3‐126: EXPLORATION OF PLASMA BIOMARKERS FOR ALZHEIMER'S DISEASE USING ISOTOPIC TANDEM MASS TAGS AND A COMBINED DIRECTED/DATA‐DEPENDENT ACQUISITION NLC‐MS/MS METHOD. Alzheimer's & Dementia 2014, 10: p674-p674. DOI: 10.1016/j.jalz.2014.05.1215.

Mehanna R, Scherzer C, Ding H, Locascio J. Unrecognized vitamin D3 deficiency is common in Parkinson disease. Neurology 2014, 82: 1666. PMID: 24799519, PMCID: PMC10845904, DOI: 10.1212/01.wnl.0000449750.81263.7d.

Ziegler D, Ashourian P, Wonderlick J, Sarokhan A, Prelec D, Scherzer C, Corkin S. Motor impulsivity in Parkinson disease: Associations with COMT and DRD2 polymorphisms. Scandinavian Journal Of Psychology 2014, 55: 278-286. PMID: 24749760, PMCID: PMC5751699, DOI: 10.1111/sjop.12113.

Cebrián C, Zucca F, Mauri P, Steinbeck J, Studer L, Scherzer C, Kanter E, Budhu S, Mandelbaum J, Vonsattel J, Zecca L, Loike J, Sulzer D. MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration. Nature Communications 2014, 5: 3633. PMID: 24736453, PMCID: PMC4024461, DOI: 10.1038/ncomms4633.

Cesani M, Cavalca E, Macco R, Leoncini G, Terreni M, Lorioli L, Furlan R, Comi G, Doglioni C, Zacchetti D, Sessa M, Scherzer C, Biffi A. Metallothioneins as dynamic markers for brain disease in lysosomal disorders. Annals Of Neurology 2014, 75: 127-137. PMID: 24242821, PMCID: PMC4237725, DOI: 10.1002/ana.24053.

Ding H, Dhima K, Lockhart K, Locascio J, Hoesing A, Duong K, Trisini-Lipsanopoulos A, Hayes M, Sohur U, Wills A, Mollenhauer B, Flaherty A, Hung A, Mejia N, Khurana V, Gomperts S, Selkoe D, Schwarzschild M, Schlossmacher M, Hyman B, Sudarsky L, Growdon J, Scherzer C. Unrecognized vitamin D3 deficiency is common in Parkinson disease. Neurology 2013, 81: 1531-1537. PMID: 24068787, PMCID: PMC3888173, DOI: 10.1212/wnl.0b013e3182a95818.

Santiago J, Scherzer C, Study H, Potashkin J. Specific splice variants are associated with Parkinson's disease. Movement Disorders 2013, 28: 1724-1727. PMID: 24108702, PMCID: PMC3812386, DOI: 10.1002/mds.25635.

Thomas B, Matson S, Chopra V, Sun L, Sharma S, Hersch S, Rosas H, Scherzer C, Ferrante R, Matson W. A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease. Analytical Biochemistry 2013, 436: 112-120. PMID: 23416183, PMCID: PMC4090024, DOI: 10.1016/j.ab.2013.01.035.

Pankratz N, Beecham G, DeStefano A, Dawson T, Doheny K, Factor S, Hamza T, Hung A, Hyman B, Ivinson A, Krainc D, Latourelle J, Clark L, Marder K, Martin E, Mayeux R, Ross O, Scherzer C, Simon D, Tanner C, Vance J, Wszolek Z, Zabetian C, Myers R, Payami H, Scott W, Foroud T, Consortium A. Meta‐analysis of Parkinson's Disease: Identification of a novel locus, RIT2. Annals Of Neurology 2012, 71: 370-384. PMID: 22451204, PMCID: PMC3354734, DOI: 10.1002/ana.22687.

van Blitterswijk M, Gulati S, Smoot E, Jaffa M, Maher N, Hyman B, Ivinson A, Scherzer C, Schoenfeld D, Cudkowicz M, Brown R, Bosco D. Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2011, 12: 430-438. PMID: 22023190, PMCID: PMC3446817, DOI: 10.3109/17482968.2011.585163.

Hu Y, Chopra V, Chopra R, Locascio J, Liao Z, Ding H, Zheng B, Matson W, Ferrante R, Rosas H, Hersch S, Scherzer C. Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 17141-17146. PMID: 21969577, PMCID: PMC3193232, DOI: 10.1073/pnas.1104409108.

Ding H, Sarokhan A, Roderick S, Bakshi R, Maher N, Ashourian P, Kan C, Chang S, Santarlasci A, Swords K, Ravina B, Hayes M, Sohur U, Wills A, Flaherty A, Unni V, Hung A, Selkoe D, Schwarzschild M, Schlossmacher M, Sudarsky L, Growdon J, Ivinson A, Hyman B, Scherzer C. Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study. Movement Disorders 2011, 26: 2283-2286. PMID: 21953863, PMCID: PMC3337217, DOI: 10.1002/mds.23934.

Hakimi M, Selvanantham T, Swinton E, Padmore R, Tong Y, Kabbach G, Venderova K, Girardin S, Bulman D, Scherzer C, LaVoie M, Gris D, Park D, Angel J, Shen J, Philpott D, Schlossmacher M. Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. Journal Of Neural Transmission 2011, 118: 795-808. PMID: 21552986, PMCID: PMC3376651, DOI: 10.1007/s00702-011-0653-2.

Zheng B, Liao Z, Locascio J, Lesniak K, Roderick S, Watt M, Eklund A, Zhang-James Y, Kim P, Hauser M, Grünblatt E, Moran L, Mandel S, Riederer P, Miller R, Federoff H, Wüllner U, Papapetropoulos S, Youdim M, Cantuti-Castelvetri I, Young A, Vance J, Davis R, Hedreen J, Adler C, Beach T, Graeber M, Middleton F, Rochet J, Scherzer C, Consortium T. PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease. Science Translational Medicine 2010, 2: 52ra73. PMID: 20926834, PMCID: PMC3129986, DOI: 10.1126/scitranslmed.3001059.

Lipinski M, Zheng B, Lu T, Yan Z, Py B, Ng A, Xavier R, Li C, Yankner B, Scherzer C, Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14164-14169. PMID: 20660724, PMCID: PMC2922576, DOI: 10.1073/pnas.1009485107.

Khurana V, Elson-Schwab I, Fulga T, Sharp K, Loewen C, Mulkearns E, Tyynelä J, Scherzer C, Feany M. Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo. PLOS Genetics 2010, 6: e1001026. PMID: 20664788, PMCID: PMC2904797, DOI: 10.1371/journal.pgen.1001026.

Cho H, Cahill C, Vanderburg C, Scherzer C, Wang B, Huang X, Rogers J. Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1* ♦. Journal Of Biological Chemistry 2010, 285: 31217-31232. PMID: 20558735, PMCID: PMC2951196, DOI: 10.1074/jbc.m110.149161.

Kim J, Amante D, Moody J, Edgerly C, Bordiuk O, Smith K, Matson S, Matson W, Scherzer C, Rosas H, Hersch S, Ferrante R. Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease. Biochimica Et Biophysica Acta 2010, 1802: 673-681. PMID: 20460152, PMCID: PMC2893277, DOI: 10.1016/j.bbadis.2010.05.001.

Mollenhauer B, Birgit O, Ng J, El‐Agnaf O, Scherzer C, Trenkwalde C. F4‐01‐03: Quantification of CSF and blood alpha‐synuclein as a diagnostic marker for synucleinopathies. Alzheimer's & Dementia 2009, 5: p148-p148. DOI: 10.1016/j.jalz.2009.05.508.

Scherzer C. Interview - Searching for biomarkers in Parkinson's disease. Biomarkers In Medicine 2009, 3: 113-114. PMID: 20477503, DOI: 10.2217/bmm.09.10.

Scherzer C. Chipping away at diagnostics for neurodegenerative diseases. Neurobiology Of Disease 2009, 35: 148-156. PMID: 19285134, PMCID: PMC2753504, DOI: 10.1016/j.nbd.2009.02.016.

Scherzer C, Grass J, Liao Z, Pepivani I, Zheng B, Eklund A, Ney P, Ng J, McGoldrick M, Mollenhauer B, Bresnick E, Schlossmacher M. GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 10907-10912. PMID: 18669654, PMCID: PMC2504800, DOI: 10.1073/pnas.0802437105.

Hennecke G, Scherzer C. RNA biomarkers of Parkinsons disease: developing tools for novel therapies. Biomarkers In Medicine 2008, 2: 41-53. PMID: 20477362, DOI: 10.2217/17520363.2.1.41.

Growdon J, Irizarry M, Scherzer C. Biomarkers for Alzheimer’s Disease and Parkinson’s Disease. Advances In Behavioral Biology 2008, 57: 169-174. DOI: 10.1007/978-0-387-72076-0_16.

Scherzer C, Eklund A, Morse L, Liao Z, Locascio J, Fefer D, Schwarzschild M, Schlossmacher M, Hauser M, Vance J, Sudarsky L, Standaert D, Growdon J, Jensen R, Gullans S. Molecular markers of early Parkinson's disease based on gene expression in blood. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 955-960. PMID: 17215369, PMCID: PMC1766335, DOI: 10.1073/pnas.0610204104.

Xu P, Li Y, Qin X, Scherzer C, Xu H, Schmechel D, Hulette C, Ervin J, Gullans S, Haines J, Pericak-Vance M, Gilbert J. Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Neurobiology Of Disease 2005, 21: 256-275. PMID: 16198584, DOI: 10.1016/j.nbd.2005.07.004.

Hauser M, Li Y, Xu H, Noureddine M, Shao Y, Gullans S, Scherzer C, Jensen R, McLaurin A, Gibson J, Scott B, Jewett R, Stenger J, Schmechel D, Hulette C, Vance J. Expression Profiling of Substantia Nigra in Parkinson Disease, Progressive Supranuclear Palsy, and Frontotemporal Dementia With Parkinsonism. JAMA Neurology 2005, 62: 917-921. PMID: 15956162, DOI: 10.1001/archneur.62.6.917.

Scherzer C, Gullans S, Jensen R. Simplifying Complex Neurodegenerative Diseases by Gene Chip Analysis. Progress In Neurological Surgery 2005, 18: 246-257. DOI: 10.1159/000084465.

Scherzer C, Offe K, Gearing M, Rees H, Fang G, Heilman C, Schaller C, Bujo H, Levey A, Lah J. Loss of Apolipoprotein E Receptor LR11 in Alzheimer Disease. JAMA Neurology 2004, 61: 1200-1205. PMID: 15313836, DOI: 10.1001/archneur.61.8.1200.

Scherzer C, Feany M. Yeast genetics targets lipids in Parkinson's disease. Trends In Genetics 2004, 20: 273-277. PMID: 15219388, DOI: 10.1016/j.tig.2004.05.005.

Li Y, Oliveira S, Xu P, Martin E, Stenger J, Hulette C, Scherzer C, Hauser M, Scott W, Small G, Nance M, Watts R, Hubble J, Koller W, Pahwa R, Stern M, Hiner B, Jankovic J, Goetz C, Mastaglia F, Middleton L, Roses A, Saunders A, Welsh-Bohmer K, Schmechel D, Gullans S, Haines J, Gilbert J, Vance J, Pericak-Vance M. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Human Molecular Genetics 2004, 13: 573-573. DOI: 10.1093/hmg/ddh059.

Li Y, Oliveira S, Xu P, Martin E, Stenger J, Scherzer C, Hauser M, Scott W, Small G, Nance M, Watts R, Hubble J, Koller W, Pahwa R, Stern M, Hiner B, Jankovic J, Goetz C, Mastaglia F, Middleton L, Roses A, Saunders A, Schmechel D, Gullans S, Haines J, Gilbert J, Vance J, Pericak-Vance M, Hulette C, Welsh-Bohmer K. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Human Molecular Genetics 2003, 12: 3259-3267. PMID: 14570706, DOI: 10.1093/hmg/ddg357.

Scherzer C, Jensen R, Gullans S, Feany M. Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease. Human Molecular Genetics 2003, 12: 2457-2466. PMID: 12915459, DOI: 10.1093/hmg/ddg265.

Thambisetty M, Scherzer C, Yu Z, Lennon V, Newman N. Paraneoplastic Optic Neuropathy and Cerebellar Ataxia With Small Cell Carcinoma of the Lung. Journal Of Neuro-Ophthalmology 2001, 21: 164-167. PMID: 11725180, DOI: 10.1097/00041327-200109000-00002.

Counihan T, Landwehrmeyer G, Standaert D, Kosinski C, Scherzer C, Daggett L, Veliçelebi G, Young A, Penney J. Expression of N‐Methyl‐D‐Aspartate receptor subunit mRNA in the human brain: Mesencephalic dopaminergic neurons. The Journal Of Comparative Neurology 1998, 390: 91-101. PMID: 9456178, DOI: 10.1002/(sici)1096-9861(19980105)390:1<91::aid-cne8>3.0.co;2-l.

Kosinski C, Standaert D, Counihan T, Scherzer C, Kerner J, Daggett L, Veliçelebi G, Penney J, Young A, Landwehrmeyer G. Expression of N‐Methyl‐D‐Aspartate receptor subunit mRNAs in the human brain: Striatum and globus pallidus. The Journal Of Comparative Neurology 1998, 390: 63-74. PMID: 9456176, DOI: 10.1002/(sici)1096-9861(19980105)390:1<63::aid-cne6>3.0.co;2-o.

Scherzer C, Landwehrmeyer G, Kerner J, Counihan T, Kosinski C, Standaert D, Daggett L, Veliçelebi G, Penney J, Young A. Expression of N‐Methyl‐D‐Aspartate receptor subunit mRNAs in the human brain: Hippocampus and cortex. The Journal Of Comparative Neurology 1998, 390: 75-90. PMID: 9456177, DOI: 10.1002/(sici)1096-9861(19980105)390:1<75::aid-cne7>3.0.co;2-n.

Priller J, Scherzer C, Faber P, MacDonald M, Yong A. Frataxin gene of Friedreich's ataxia is targeted to mitochondria. Annals Of Neurology 1997, 42: 265-269. PMID: 9266741, DOI: 10.1002/ana.410420222.

Scherzer C, Landwehrmeyer G, Kerner J, Standaert D, Hollingsworth Z, Daggett L, Veliçelebi G, Penney J, Young A. Cellular Distribution of NMDA Glutamate Receptor Subunit mRNAs in the Human Cerebellum. Neurobiology Of Disease 1997, 4: 35-46. PMID: 9258910, DOI: 10.1006/nbdi.1997.0136.