Brian Richard Smith, MD
Laboratory Medicine, Hematopathology, Hematology & Oncology, Internal Medicine
Titles
- Professor of Laboratory Medicine, of Biomedical Engineering, of Medicine (Hematology) and of Pediatrics
- Deputy Dean for Research, (Clinical and Translational)
- Director, Clinical Immunology Laboratory, Laboratory Medicine
- Chair, Laboratory Medicine
- Chief, Laboratory Medicine
Education & Training
- FellowBrigham & Women's Hospital/Dana Farber Cancer Center/Children's Hospital,Boston (1982)
- ResidentBrigham & Women's Hospital/Harvard Medical School (1978)
- MDHarvard University (1976)
- BAPrinceton University, Chemistry (1972)
Additional Information
Honors & Recognitions
- Evans Award for Outstanding Contributions to Laboratory Medicine: Academy of Clinical Laboratory Physicians & Scientists (2010)
- Chair (elected), Research Committee and Member of the Council: Association of Pathology Chairs (2010)
- President, Academy of Clinical Laboratory Physicians & Scientists: Academy of Clinical Laboratory Physicians & Scientists (2007), (2008)
Board Certifications
- AB of Pathology, Hematology (Pathology) (1999)
- AB of Internal Medicine, Medical Oncology (1981)
- AB of Internal Medicine, Hematology (Internal Medicine) (1980)
- AB of Internal Medicine, Internal Medicine (1979)
Publications
- Schulz WL, Rinder HM, Durant TJS, Tormey CA, Torres R, Smith BR, Hager KM, Howe JG, Siddon AJ. Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival. Leukemia & Lymphoma 2020, 61: 3269-3271. PMID: 32715805, DOI: 10.1080/10428194.2020.1797016.
- Rifai N, Smith BR, Connelly MT. A Message to Medical School Promotion Committees: Proper Credit for Peer-Reviewed Online Educational Materials. Clinical Chemistry 2019, 65: 715-717. PMID: 31003977, DOI: 10.1373/clinchem.2019.305862.
- False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With AlemtuzumabChen PP, Tormey CA, Eisenbarth SC, Torres R, Richardson SS, Rinder HM, Smith BR, Siddon AJ. False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab. American Journal Of Clinical Pathology 2018, 151: 154-163. PMID: 30307483, DOI: 10.1093/ajcp/aqy129.
- Perincheri S, Torres R, Tormey C, Smith B, Rinder H, Siddon A. Daratumumab Interferes with Flow Cytometric Evaluation of Multiple Myeloma. Blood 2016, 128: 5630. DOI: 10.1182/blood.v128.22.5630.5630.
- Smith BR, Kamoun M, Hickner J. Laboratory Medicine Education at U.S. Medical Schools. Academic Medicine 2016, 91: 107-112. PMID: 26200574, PMCID: PMC5480607, DOI: 10.1097/acm.0000000000000817.
- Remick DG, Lorenz RG, Smith BR. Opportunity: Newly Created Physician-Scientist Research Pathway by the American Board of Pathology. Academic Pathology 2016, 3: 2374289516632240. PMID: 28725759, PMCID: PMC5497862, DOI: 10.1177/2374289516632240.
- Schulz W, Durant T, Rinder H, Tormey C, Torres R, Smith B, Hager K, Howe J, Siddon A. Impact of Molecular Clonality on Survival in Acute Myeloid Leukemia. Blood 2015, 126: 1385. DOI: 10.1182/blood.v126.23.1385.1385.
- Abi‐Raad R, Smith BR. Biosimilar biologics: never identical but close enough. Transfusion 2015, 55: 229-231. PMID: 25683185, DOI: 10.1111/trf.12961.
- Torres R, Tormey C, Smith B. Hematology in Clinical Pathology. 2014, 3269-3286. DOI: 10.1016/b978-0-12-386456-7.06305-x.
- Smith B, Rinder H. Chapter 52 Cardiopulmonary Bypass. 2013, 1075-1096. DOI: 10.1016/b978-0-12-387837-3.00052-3.
- Tormey CA, Smith BR. Transfusion Medicine and Coagulation Consultation. Transfusion 2012, 53: 2086-2093. PMID: 23228202, DOI: 10.1111/trf.12012.
- Ziai JM, Smith BR. Pathology Resident and Fellow Education in a Time of Disruptive Technologies. Clinics In Laboratory Medicine 2012, 32: 623-638. PMID: 23078663, DOI: 10.1016/j.cll.2012.07.004.
- Scott MG, Smith BR, Wu AH, Young IS, Plebani M, Chiu RW. How well are we training the next generation of clinical pathologists and clinical laboratory directors? A global perspective. Clinical Chemistry 2012, 58: 491-5. PMID: 21969387, DOI: 10.1373/clinchem.2011.171199.
- Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Bock JL, Campbell S, Crookston KP, Fitzgerald R, Fung M, Haspel R, Howe JG, Jhang J, Kamoun M, Koethe S, Krasowski MD, Landry ML, Marques MB, Rinder HM, Roberts W, Schreiber WE, Spitalnik SL, Tormey CA, Wolf P, Wu YY. Educating Medical Students in Laboratory Medicine. American Journal Of Clinical Pathology 2010, 133: 533-542. PMID: 20231605, DOI: 10.1309/ajcpqct94sferlni.
- Smith BR. Therapeutic pathology: time to move beyond diagnostics. Human Pathology 2008, 39: 1725-1727. PMID: 18656233, DOI: 10.1016/j.humpath.2008.04.004.
- Wells A, Smith BR. The Goals of Resident Training in Laboratory Medicine in Combined Anatomic Pathology/Clinical Pathology Programs: An Overview. Clinics In Laboratory Medicine 2007, 27: 229-240. PMID: 17556082, DOI: 10.1016/j.cll.2007.03.001.
- Smith B. Preface. Clinics In Laboratory Medicine 2007, 27: xi-xiii. DOI: 10.1016/j.cll.2007.04.002.
- Smith B, Rinder H, Rinder C. Chapter 59 Cardiopulmonary bypass. 2007, 1077-1095. DOI: 10.1016/b978-012369367-9/50821-1.
- Smith BR, Wells A, Alexander CB, Bovill E, Campbell S, Dasgupta A, Fung M, Haller B, Howe JG, Parvin C, Peerschke E, Rinder H, Spitalnik S, Weiss R, Wener M. Curriculum Content and Evaluation of Resident Competency in Clinical Pathology (Laboratory Medicine): A Proposal. Clinical Chemistry 2006, 52: 917-949. PMID: 16569705, DOI: 10.1373/clinchem.2005.066076.
- Howe J, Crouch J, Smith B. Development of a BCR/ABL Real-Time Quantitative RT-PCR Assay and Correlation with an Existing Qualitative Test. Blood 2005, 106: 4879. DOI: 10.1182/blood.v106.11.4879.4879.
- Murphy S, Rinder H, Smith B. Utility of in vitro tests in predicting the in vivo viability of stored PLTs. Transfusion 2004, 44: 618-619. PMID: 15043581, DOI: 10.1111/j.1537-2995.2004.00355.x.
- Griffin M, Rinder H, Smith B, Tracey J, Kriz N, Li C, Rinder C. The Effects of Heparin, Protamine, and Heparin/Protamine Reversal on Platelet Function Under Conditions of Arterial Shear Stress. Anesthesia & Analgesia 2001, 93: 20-27. PMID: 11429331, DOI: 10.1097/00000539-200107000-00005.
- Mathew J, Rinder C, Howe J, Fontes M, Crouch J, Newman M, Phillips-Bute B, Smith B, Group T. Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass. The Annals Of Thoracic Surgery 2001, 71: 663-666. PMID: 11235724, DOI: 10.1016/s0003-4975(00)02335-3.
- Debelak J, Shlomchik M, Snyder E, Cooper D, Seropian S, McGuirk J, Smith B, Krause D. Isolation and flow cytometric analysis of T‐cell‐depleted CD34+ PBPCs. Transfusion 2000, 40: 1475-1481. PMID: 11134567, DOI: 10.1046/j.1537-2995.2000.40121475.x.
- Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.
- Jillella A, Doria R, Khan K, Zelterman D, Ahmad Y, Smith B, Holmes W, Becker P, Roberts K, Rappeport J. Cyclophosphamide, cytosine arabinoside and TBI as a conditioning regimen for allogeneic bone marrow transplantation in patients with leukemia. Bone Marrow Transplantation 1999, 23: 1095-1100. PMID: 10382947, DOI: 10.1038/sj.bmt.1701786.
- Griffin M, Li C, Rinder H, Smith B, Rinder C. OPTIMAL HEPARIN-PROTAMINE REVERSAL RATIO. Anesthesia & Analgesia 1999, 88: 106sca.. DOI: 10.1097/00000539-199904001-00106.
- Mathew J, Fontes M, Phillips-Bute B, Rinder H, Herskowitz A, Smith B, Newman M, Rinder C. PLATELET ACTIVATION DURING CARDIOPULMONARY BYPASS PREDICTS POSTOPERATIVE NEUROCOGNITIVE DECLINE. Anesthesia & Analgesia 1999, 88: 109sca.. DOI: 10.1097/00000539-199904001-00109.
- Crotty P, Smith B, Tallini G. Morphologic, Immunophenotypic, and Molecular Evaluation of Bone Marrow Involvement in Non-Hodgkin's Lymphoma. Applied Immunohistochemistry & Molecular Morphology 1998, 7: 90-95. PMID: 9785007, DOI: 10.1097/00019606-199804000-00005.
- Rollins S, Fitch J, Shernan S, Rinder C, Rinder H, Smith B, Collard C, Stahl G, Alford B, Li L, Matis L. Anti-C5 single chain antibody therapy blocks complement & leukocyte activation and reduces myocardial tissue damage in CPB patients. Molecular Immunology 1998, 35: 397. DOI: 10.1016/s0161-5890(98)90798-2.
- Afifi S, Hashim S, Mathew J, Fontes M, Davis E, Tracey J, Smith B, Rinder C. TISSUE FACTOR PATHWAY INHIBITOR RISES AND MONOCYTE TISSUE FACTOR RESPONSE TO ENDOTOXIN FALLS DURING CPB. Anesthesia & Analgesia 1998, 86: 2sca.. DOI: 10.1213/00000539-199804001-00002.
- Lee D, Smith M, Tracey J, Johnson K, Higgins P, Yeh C, Smith B, Rinder C. C3- AND C5- CONVERTASE INHIBITION PREVENTS MONOCYTE AND PMN ACTIVATION DURING IN VITRO CARDIOPULMONARY BYPASS. Anesthesia & Analgesia 1998, 86: 1sca.. DOI: 10.1213/00000539-199804001-00001.
- Rinder H, Schuster J, Rinder C, Wang C, Schweidler H, Smith B. Correlation of Thrombosis With Increased Platelet Turnover in Thrombocytosis. Blood 1998, 91: 1288-1294. PMID: 9454759, DOI: 10.1182/blood.v91.4.1288.
- Crouch J, Leitenberg D, Smith B, Howe J. Epstein‐Barr virus suspension cell assay using in situ hybridization and flow cytometry. Cytometry 1997, 29: 50-57. PMID: 9298811, DOI: 10.1002/(sici)1097-0320(19970901)29:1<50::aid-cyto5>3.0.co;2-h.
- Rinder C, Mathew J, Rinder H, Tracey J, Davis E, Smith B. Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender. Translational Research 1997, 129: 592-602. PMID: 9178725, DOI: 10.1016/s0022-2143(97)90193-1.
- HARRIS S, RINDER C, RINDER H, TRACEY J, SMITH B, HINES R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Survey Of Anesthesiology 1996, 40: 326. DOI: 10.1097/00132586-199610000-00069.
- Ross G, Erickson R, Knorr D, Motulsky A, Parkman R, Samulski J, Straus S, Smith B. Gene Therapy in the United States: A Five-Year Status Report. Human Gene Therapy 1996, 7: 1781-1790. PMID: 8886849, DOI: 10.1089/hum.1996.7.14-1781.
- Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.
- Leitenberg D, Constant S, Lu D, Smith B, Bottomly K. CD4 and CD45 regulate qualitatively distinct patterns of calcium mobilization in individual CD4+ T cells. European Journal Of Immunology 1995, 25: 2445-2451. PMID: 7589109, DOI: 10.1002/eji.1830250906.
- Leitenberg D, Eisen R, Goldstein J, Busque L, Rinder H, Stys P, Katz M, Gilliland D, Smith B. Natural killer cell lymphoproliferative disease associated with neuropathy. The American Journal Of Medicine 1995, 99: 99-101. PMID: 7598151, DOI: 10.1016/s0002-9343(99)80112-0.
- Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypassMathew J, Rinder C, Tracey J, Auszura L, O'Connor T, Davis E, Smith B. Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass. Journal Of Thoracic And Cardiovascular Surgery 1995, 109: 448-456. PMID: 7877305, DOI: 10.1016/s0022-5223(95)70275-x.
- Leitenberg D, Rappeport J, Smith B. B-Cell Precursor Bone Marrow Reconstitution After Bone Marrow Transplantation. American Journal Of Clinical Pathology 1994, 102: 231-236. PMID: 8042594, DOI: 10.1093/ajcp/102.2.231.
- Buc N, Capron A, Carmen I, Chase G, DeLeon P, Doi R, Dronamraju K, Geiduschek E, Haselkorn R, Hirano S, Krogstad D, Miller A, Motulsky A, Parkman R, Post L, Secundy M, Smith B, Straus S, Walters L, Zallen D. Minutes of the September 910, 1993 Recombinant DNA Advisory Committee Meeting. Human Gene Therapy 1994, 5: 645-660. DOI: 10.1089/hum.1994.5.5-645.
- Rinder H, Tracey J, Rinder C, Leitenberg D, Smith B. Neutrophil but not Monocyte Activation Inhibits P-Selectin-Mediated Platelet Adhesion*. Thrombosis And Haemostasis 1994, 72: 750-756. PMID: 7534948, DOI: 10.1055/s-0038-1648953.
- Rinder C, Gaal D, Student L, Smith B. Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass. Journal Of Thoracic And Cardiovascular Surgery 1994, 107: 280-288. PMID: 8283897, DOI: 10.1016/s0022-5223(94)70482-1.
- Rinder H, Bonan J, Anandan S, Rinder C, Rodrigues P, Smith B. Noninvasive measurement of platelet kinetics in normal and hypertensive pregnancies. American Journal Of Obstetrics And Gynecology 1994, 170: 117-122. DOI: 10.1016/s0002-9378(13)70291-6.
- Bonan J, Rinder H, Smith B. Determination of the percentage of thiazole orange (TO)‐positive, “reticulated” platelets using autologous erythrocyte TO fluorescence as an internal standard. Cytometry 1993, 14: 690-694. PMID: 8404376, DOI: 10.1002/cyto.990140615.
- Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin Does Not Inhibit Adenosine Diphosphate-Induced Platelet α-Granule Release. Blood 1993, 82: 505-512. PMID: 7687162, DOI: 10.1182/blood.v82.2.505.505.
- Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin does not inhibit adenosine diphosphate-induced platelet alpha- granule release. Blood 1993, 82: 505-512. DOI: 10.1182/blood.v82.2.505.bloodjournal822505.
- SMITH B. Integrating Flow Cytometry in the Hematology Laboratory. Annals Of The New York Academy Of Sciences 1993, 677: 326-333. PMID: 8494218, DOI: 10.1111/j.1749-6632.1993.tb38787.x.
- SMITH B. Qualitative versus Quantitative Immunophenotypinga. Annals Of The New York Academy Of Sciences 1993, 677: 152-154. PMID: 8494204, DOI: 10.1111/j.1749-6632.1993.tb38773.x.
- Macklis R, Mauch P, Thompson L, Burakoff S, Smith B. Phenotypic and Functional Analysis of Expanded Natural Killer Cell Subpopulations in Hodgkin’s Disease Patients Treated with Lymphoid Irradiation. Oncology 1993, 50: 323-328. PMID: 8497384, DOI: 10.1159/000227203.
- Wiebe V, Smith B, DeGregorio M, Rappeport J. Pharmacology of agents used in bone marrow transplant conditioning regimens. Critical Reviews In Oncology/Hematology 1992, 13: 241-270. PMID: 1476655, DOI: 10.1016/1040-8428(92)90092-5.
- Gaal D, Rinder C, Student L, Smith B. CELLULAR ACTIVATION ON PEDIATRIC CPB. Anesthesiology 1992, 77: a1137. DOI: 10.1097/00000542-199209001-01137.
- Maziarz R, Arced R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A γδ+ T-Cell Leukemia Bearing a Novel t(8;14)(q24;q11) Translocation Demonstrates Spontaneous In Vitro Natural Killer-Like Activity. Blood 1992, 79: 1523-1531. DOI: 10.1182/blood.v79.6.1523.1523.
- Maziarz R, Arceci R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity. Blood 1992, 79: 1523-31. PMID: 1532137, DOI: 10.1182/blood.v79.6.1523.bloodjournal7961523.
- Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion. Blood 1992, 79: 1201-1205. PMID: 1371416, DOI: 10.1182/blood.v79.5.1201.1201.
- Smith BR. Can medical rationing be made rational? Archives Of Internal Medicine 1992, 152: 476-7. PMID: 1546908.
- Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992, 79: 1201-1205. DOI: 10.1182/blood.v79.5.1201.bloodjournal7951201.
- Antin J, Bierer B, Smith B, Ferrara J, Guinan E, Sieff C, Golan D, Macklis R, Tarbell N, Lynch E, Reichert T, Blythman H, Bouloux C, Rappeport J, Burakoff S, Weinstein H. Selective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies. Blood 1991, 78: 2139-2149. PMID: 1717080, DOI: 10.1182/blood.v78.8.2139.2139.
- Antin J, Bierer B, Smith B, Ferrara J, Guinan E, Sieff C, Golan D, Macklis R, Tarbell N, Lynch E. Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies. Blood 1991, 78: 2139-2149. DOI: 10.1182/blood.v78.8.2139.bloodjournal7882139.
- Rinder C, Mathew J, Rinder H, Bonan J, Ault K, Smith B. Modulation of Platelet Surface Adhesion Receptors during Cardiopulmonary Bypass. Anesthesiology 1991, 75: 563-570. PMID: 1718190, DOI: 10.1097/00000542-199110000-00004.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Dynamics of leukocyte-platelet adhesion in whole blood. Blood 1991, 78: 1730-7. PMID: 1717069, DOI: 10.1182/blood.v78.7.1730.bloodjournal7871730.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Activated and unactivated platelet adhesion to monocytes and neutrophils. Blood 1991, 78: 1760-9. PMID: 1717070, DOI: 10.1182/blood.v78.7.1760.bloodjournal7871760.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Dynamics of Leukocyte-Platelet Adhesion in Whole Blood. Blood 1991, 78: 1730-1737. DOI: 10.1182/blood.v78.7.1730.1730.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Activated and Unactivated Platelet Adhesion to Monocytes and Neutrophils. Blood 1991, 78: 1760-1769. DOI: 10.1182/blood.v78.7.1760.1760.
- Rinder C, Hathew J, Bonan J, Smith B. PLATELET–LEUKOCYTE BINDING ON CARDIOPULMONARY BYPASS. Anesthesiology 1991, 75: a58. DOI: 10.1097/00000542-199109001-00058.
- Rinder C, Mathew J, Bonan J, Hines R, Smith B. CPB INDUCES INCREASED LEUKOCYTE ADHESION RECEPTORS BUT NOT TNF-α. Anesthesiology 1991, 75: a59. DOI: 10.1097/00000542-199109001-00059.
- Strair R, Towle M, Heald P, Smith B. Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells: assaying for a viral transactivator activity in normal and malignant cells. Blood 1990, 76: 1201-8. PMID: 2144777, DOI: 10.1182/blood.v76.6.1201.bloodjournal7661201.
- Strair R, Towle M, Heald P, Smith B. Retroviral Mediated Transfer and Expression of Exogenous Genes in Primary Lymphoid Cells: Assaying for a Viral Transactivator Activity in Normal and Malignant Cells. Blood 1990, 76: 1201-1208. DOI: 10.1182/blood.v76.6.1201.1201.
- Rinder C, Rinder H, Ault K, Smith B. A74 PLATELET RECEPTORS FOR ADHESIVE LIGANDS ARE DECREASED DURING CARDIOPULMONARY BYPASS. Anesthesiology 1990, 73: na. DOI: 10.1097/00000542-199009001-00074.
- Strair R, Towle M, Smith B. Retroviral mediated gene transfer into bone marrow progenitor cells: use of beta-galactosidase as a selectable marker. Nucleic Acids Research 1990, 18: 4759-4762. PMID: 2118622, PMCID: PMC331937, DOI: 10.1093/nar/18.16.4759.
- Mitus A, Stein R, Rappeport J, Antin J, Weinstein H, Alper C, Smith B. Monoclonal and oligoclonal gammopathy after bone marrow transplantation. Blood 1989, 74: 2764-8. PMID: 2819246, DOI: 10.1182/blood.v74.8.2764.bloodjournal7482764.
- Mitus A, Stein R, Rappeport J, Antin J, Weinstein H, Alper C, Smith B. Monoclonal and Oligoclonal Gammopathy After Bone Marrow Transplantation. Blood 1989, 74: 2764-2768. DOI: 10.1182/blood.v74.8.2764.2764.
- Niemeyer C, Sieff C, Smith B, Ault K, Nathan D. Hematopoiesis in vitro coexists with natural killer lymphocytes. Blood 1989, 74: 2376-82. PMID: 2529928, DOI: 10.1182/blood.v74.7.2376.bloodjournal7472376.
- Niemeyer C, Sieff C, Smith B, Ault K, Nathan D. Hematopoiesis In Vitro Coexists With Natural Killer Lymphocytes. Blood 1989, 74: 2376-2382. DOI: 10.1182/blood.v74.7.2376.2376.
- Ibrahim R, Teich D, Smith B, Antin J, Olivier A, Weinberg D. Flow cytometric surface light chain analysis of lymphocyte‐rich effusions. A useful adjunct to cytologic diagnosis. Cancer 1989, 63: 2024-2029. PMID: 2495164, DOI: 10.1002/1097-0142(19890515)63:10<2024::aid-cncr2820631026>3.0.co;2-h.
- Bierer B, Burakoff S, Smith B. A large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation. Blood 1989, 73: 1359-66. PMID: 2467708, DOI: 10.1182/blood.v73.5.1359.bloodjournal7351359.
- Bierer B, Burakoff S, Smith B. A Large Proportion of T Lymphocytes Lack CD5 Expression After Bone Marrow Transplantation. Blood 1989, 73: 1359-1366. DOI: 10.1182/blood.v73.5.1359.1359.
- Guinan E, Smith B, Doukas J, Miller R, Pober J. Vascular endothelial cells enhance T cell responses by markedly augmenting IL-2 concentrations. Cellular Immunology 1989, 118: 166-177. PMID: 2562928, DOI: 10.1016/0008-8749(89)90366-3.
- Bierer B, Emerson S, Antin J, Maziarz R, Rappeport J, Smith B, Burakoff A. REGULATION OF CYTOTOXIC T LYMPHOCYTE-MEDIATED GRAFT REJECTION FOLLOWING BONE MARROW. Transplantation 1988, 46: 835-839. PMID: 3061078, DOI: 10.1097/00007890-198812000-00009.
- Antin J, Smith B, Holmes W, Rosenthal D. Phase I/II study of recombinant human granulocyte-macrophage colony-stimulating factor in aplastic anemia and myelodysplastic syndrome. Blood 1988, 72: 705-13. PMID: 3042046, DOI: 10.1182/blood.v72.2.705.bloodjournal722705.
- Antin J, Smith B, Holmes W, Rosenthal D. Phase I/II Study of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Aplastic Anemia and Myelodysplastic Syndrome. Blood 1988, 72: 705-713. DOI: 10.1182/blood.v72.2.705.705.
- Daley J, Rozans M, Smith B, Burakoff S, Rappeport J, Miller R. Retarded recovery of functional T cell frequencies in T cell-depleted bone marrow transplant recipients. Blood 1987, 70: 960-4. PMID: 3307954, DOI: 10.1182/blood.v70.4.960.bloodjournal704960.
- Daley J, Rozans M, Smith B, Burakoff S, Rappeport J, Miller R. Retarded Recovery of Functional T Cell Frequencies in T Cell–Depleted Bone Marrow Transplant Recipients. Blood 1987, 70: 960-964. DOI: 10.1182/blood.v70.4.960.960.
- Rozans M, Smith B, Emerson S, Crimmins M, Laurent G, Reichert T, Burakoff S, Miller R. FUNCTIONAL ASSESSMENT OF T CELL DEPLETION FROM BONE MARROW PRIOR TO THERAPEUTIC TRANSPLANTATION USING LIMITING DILUTION CULTURE METHODS. Transplantation 1986, 42: 380-386. PMID: 3094209, DOI: 10.1097/00007890-198610000-00010.
- Patenaude A, Rappeport J, Smith B. The physician's influence on informed consent for bone marrow transplantation. Theoretical Medicine And Bioethics 1986, 7: 165-179. PMID: 3526626, DOI: 10.1007/bf00489228.
- Antin J, Smith B, Ewenstein B, Arceci R, Lipton J, Page P, Rappeport J. HTLV-III Infection After Bone Marrow Transplantation. Blood 1986, 67: 160-163. DOI: 10.1182/blood.v67.1.160.160.
- Antin J, Ginsburg D, Smith B, Nathan D, Orkin S, Rappeport J. Bone Marrow Transplantation for Paroxysmal Nocturnal Hemoglobinuria: Eradication of the PNH Clone and Documentation of Complete Lymphohematopoietic Engraftment. Blood 1985, 66: 1247-1250. DOI: 10.1182/blood.v66.6.1247.1247.
- Louie E, Ault K, Smith B, Hardman E, Quesenberry P. IgG‐mediated haemolysis masquerading as cold agglutinin‐induced anaemia complicating severe infection with Mycoplasma pneumoniae. European Journal Of Haematology 1985, 35: 264-269. PMID: 3933104, DOI: 10.1111/j.1600-0609.1985.tb01705.x.
- First L, Smith B, Lipton J, Nathan D, Parkman R, Rappeport J. Isolated Thrombocytopenia After Allogeneic Bone Marrow Transplantation: Existence of Transient and Chronic Thrombocytopenic Syndromes. Blood 1985, 65: 368-374. DOI: 10.1182/blood.v65.2.368.368.
- Smith B, Weinberg D, Robert N, Towle M, Luther E, Pinkus G, Ault K. Circulating Monoclonal B Lymphocytes in Non-Hodgkin's Lymphoma. New England Journal Of Medicine 1984, 311: 1476-1481. PMID: 6438505, DOI: 10.1056/nejm198412063112304.
- Parkman R, Rappeport J, Hellman S, Lipton J, Smith B, Geha R, Nathan D. Busulfan and Total Body Irradiation as Antihematopoietic Stem Cell Agents in the Preparation of Patients With Congenital Bone Marrow Disorders for Allogeneic Bone Marrow Transplantation. Blood 1984, 64: 852-857. DOI: 10.1182/blood.v64.4.852.852.
- First L, Smith B, Lipton J, Nathan D, Parkman R, Rappeport J. ISOLATED THROMBOCYTOPENIA FOLLOWING ALLOGENEIC BONE MARROW TRANSPLANTATION. Pediatric Research 1984, 18: 240-240. DOI: 10.1203/00006450-198404001-00880.
- Rappeport J, Smith B, Parkman R, Rosen F. Application of bone marrow transplantation in genetic diseases. Clinics In Haematology 1983, 12: 755-773. PMID: 6416728, DOI: 10.1016/s0308-2261(83)80009-5.
- Bloch D, Smith B, Ault K. Cells on microspheres: A new technique for flow cytometric analysis of adherent cells. Cytometry 1983, 3: 449-452. PMID: 6343013, DOI: 10.1002/cyto.990030611.
- Smith B, Robert N, Ault K. In Waldenstrom's Macroglobulinemia the Quantity of Detectable Circulating Monoclonal B Lymphocytes Correlates With Clinical Course. Blood 1983, 61: 911-914. DOI: 10.1182/blood.v61.5.911.911.
Titles
- Professor of Laboratory Medicine, of Biomedical Engineering, of Medicine (Hematology) and of Pediatrics
- Deputy Dean for Research, (Clinical and Translational)
- Director, Clinical Immunology Laboratory, Laboratory Medicine
- Chair, Laboratory Medicine
- Chief, Laboratory Medicine
Education & Training
- FellowBrigham & Women's Hospital/Dana Farber Cancer Center/Children's Hospital,Boston (1982)
- ResidentBrigham & Women's Hospital/Harvard Medical School (1978)
- MDHarvard University (1976)
- BAPrinceton University, Chemistry (1972)
Additional Information
Honors & Recognitions
- Evans Award for Outstanding Contributions to Laboratory Medicine: Academy of Clinical Laboratory Physicians & Scientists (2010)
- Chair (elected), Research Committee and Member of the Council: Association of Pathology Chairs (2010)
- President, Academy of Clinical Laboratory Physicians & Scientists: Academy of Clinical Laboratory Physicians & Scientists (2007), (2008)
Board Certifications
- AB of Pathology, Hematology (Pathology) (1999)
- AB of Internal Medicine, Medical Oncology (1981)
- AB of Internal Medicine, Hematology (Internal Medicine) (1980)
- AB of Internal Medicine, Internal Medicine (1979)
Publications
- Schulz WL, Rinder HM, Durant TJS, Tormey CA, Torres R, Smith BR, Hager KM, Howe JG, Siddon AJ. Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival. Leukemia & Lymphoma 2020, 61: 3269-3271. PMID: 32715805, DOI: 10.1080/10428194.2020.1797016.
- Rifai N, Smith BR, Connelly MT. A Message to Medical School Promotion Committees: Proper Credit for Peer-Reviewed Online Educational Materials. Clinical Chemistry 2019, 65: 715-717. PMID: 31003977, DOI: 10.1373/clinchem.2019.305862.
- False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With AlemtuzumabChen PP, Tormey CA, Eisenbarth SC, Torres R, Richardson SS, Rinder HM, Smith BR, Siddon AJ. False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab. American Journal Of Clinical Pathology 2018, 151: 154-163. PMID: 30307483, DOI: 10.1093/ajcp/aqy129.
- Perincheri S, Torres R, Tormey C, Smith B, Rinder H, Siddon A. Daratumumab Interferes with Flow Cytometric Evaluation of Multiple Myeloma. Blood 2016, 128: 5630. DOI: 10.1182/blood.v128.22.5630.5630.
- Smith BR, Kamoun M, Hickner J. Laboratory Medicine Education at U.S. Medical Schools. Academic Medicine 2016, 91: 107-112. PMID: 26200574, PMCID: PMC5480607, DOI: 10.1097/acm.0000000000000817.
- Remick DG, Lorenz RG, Smith BR. Opportunity: Newly Created Physician-Scientist Research Pathway by the American Board of Pathology. Academic Pathology 2016, 3: 2374289516632240. PMID: 28725759, PMCID: PMC5497862, DOI: 10.1177/2374289516632240.
- Schulz W, Durant T, Rinder H, Tormey C, Torres R, Smith B, Hager K, Howe J, Siddon A. Impact of Molecular Clonality on Survival in Acute Myeloid Leukemia. Blood 2015, 126: 1385. DOI: 10.1182/blood.v126.23.1385.1385.
- Abi‐Raad R, Smith BR. Biosimilar biologics: never identical but close enough. Transfusion 2015, 55: 229-231. PMID: 25683185, DOI: 10.1111/trf.12961.
- Torres R, Tormey C, Smith B. Hematology in Clinical Pathology. 2014, 3269-3286. DOI: 10.1016/b978-0-12-386456-7.06305-x.
- Smith B, Rinder H. Chapter 52 Cardiopulmonary Bypass. 2013, 1075-1096. DOI: 10.1016/b978-0-12-387837-3.00052-3.
- Tormey CA, Smith BR. Transfusion Medicine and Coagulation Consultation. Transfusion 2012, 53: 2086-2093. PMID: 23228202, DOI: 10.1111/trf.12012.
- Ziai JM, Smith BR. Pathology Resident and Fellow Education in a Time of Disruptive Technologies. Clinics In Laboratory Medicine 2012, 32: 623-638. PMID: 23078663, DOI: 10.1016/j.cll.2012.07.004.
- Scott MG, Smith BR, Wu AH, Young IS, Plebani M, Chiu RW. How well are we training the next generation of clinical pathologists and clinical laboratory directors? A global perspective. Clinical Chemistry 2012, 58: 491-5. PMID: 21969387, DOI: 10.1373/clinchem.2011.171199.
- Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Bock JL, Campbell S, Crookston KP, Fitzgerald R, Fung M, Haspel R, Howe JG, Jhang J, Kamoun M, Koethe S, Krasowski MD, Landry ML, Marques MB, Rinder HM, Roberts W, Schreiber WE, Spitalnik SL, Tormey CA, Wolf P, Wu YY. Educating Medical Students in Laboratory Medicine. American Journal Of Clinical Pathology 2010, 133: 533-542. PMID: 20231605, DOI: 10.1309/ajcpqct94sferlni.
- Smith BR. Therapeutic pathology: time to move beyond diagnostics. Human Pathology 2008, 39: 1725-1727. PMID: 18656233, DOI: 10.1016/j.humpath.2008.04.004.
- Wells A, Smith BR. The Goals of Resident Training in Laboratory Medicine in Combined Anatomic Pathology/Clinical Pathology Programs: An Overview. Clinics In Laboratory Medicine 2007, 27: 229-240. PMID: 17556082, DOI: 10.1016/j.cll.2007.03.001.
- Smith B. Preface. Clinics In Laboratory Medicine 2007, 27: xi-xiii. DOI: 10.1016/j.cll.2007.04.002.
- Smith B, Rinder H, Rinder C. Chapter 59 Cardiopulmonary bypass. 2007, 1077-1095. DOI: 10.1016/b978-012369367-9/50821-1.
- Smith BR, Wells A, Alexander CB, Bovill E, Campbell S, Dasgupta A, Fung M, Haller B, Howe JG, Parvin C, Peerschke E, Rinder H, Spitalnik S, Weiss R, Wener M. Curriculum Content and Evaluation of Resident Competency in Clinical Pathology (Laboratory Medicine): A Proposal. Clinical Chemistry 2006, 52: 917-949. PMID: 16569705, DOI: 10.1373/clinchem.2005.066076.
- Howe J, Crouch J, Smith B. Development of a BCR/ABL Real-Time Quantitative RT-PCR Assay and Correlation with an Existing Qualitative Test. Blood 2005, 106: 4879. DOI: 10.1182/blood.v106.11.4879.4879.
- Murphy S, Rinder H, Smith B. Utility of in vitro tests in predicting the in vivo viability of stored PLTs. Transfusion 2004, 44: 618-619. PMID: 15043581, DOI: 10.1111/j.1537-2995.2004.00355.x.
- Griffin M, Rinder H, Smith B, Tracey J, Kriz N, Li C, Rinder C. The Effects of Heparin, Protamine, and Heparin/Protamine Reversal on Platelet Function Under Conditions of Arterial Shear Stress. Anesthesia & Analgesia 2001, 93: 20-27. PMID: 11429331, DOI: 10.1097/00000539-200107000-00005.
- Mathew J, Rinder C, Howe J, Fontes M, Crouch J, Newman M, Phillips-Bute B, Smith B, Group T. Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass. The Annals Of Thoracic Surgery 2001, 71: 663-666. PMID: 11235724, DOI: 10.1016/s0003-4975(00)02335-3.
- Debelak J, Shlomchik M, Snyder E, Cooper D, Seropian S, McGuirk J, Smith B, Krause D. Isolation and flow cytometric analysis of T‐cell‐depleted CD34+ PBPCs. Transfusion 2000, 40: 1475-1481. PMID: 11134567, DOI: 10.1046/j.1537-2995.2000.40121475.x.
- Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.
- Jillella A, Doria R, Khan K, Zelterman D, Ahmad Y, Smith B, Holmes W, Becker P, Roberts K, Rappeport J. Cyclophosphamide, cytosine arabinoside and TBI as a conditioning regimen for allogeneic bone marrow transplantation in patients with leukemia. Bone Marrow Transplantation 1999, 23: 1095-1100. PMID: 10382947, DOI: 10.1038/sj.bmt.1701786.
- Griffin M, Li C, Rinder H, Smith B, Rinder C. OPTIMAL HEPARIN-PROTAMINE REVERSAL RATIO. Anesthesia & Analgesia 1999, 88: 106sca.. DOI: 10.1097/00000539-199904001-00106.
- Mathew J, Fontes M, Phillips-Bute B, Rinder H, Herskowitz A, Smith B, Newman M, Rinder C. PLATELET ACTIVATION DURING CARDIOPULMONARY BYPASS PREDICTS POSTOPERATIVE NEUROCOGNITIVE DECLINE. Anesthesia & Analgesia 1999, 88: 109sca.. DOI: 10.1097/00000539-199904001-00109.
- Crotty P, Smith B, Tallini G. Morphologic, Immunophenotypic, and Molecular Evaluation of Bone Marrow Involvement in Non-Hodgkin's Lymphoma. Applied Immunohistochemistry & Molecular Morphology 1998, 7: 90-95. PMID: 9785007, DOI: 10.1097/00019606-199804000-00005.
- Rollins S, Fitch J, Shernan S, Rinder C, Rinder H, Smith B, Collard C, Stahl G, Alford B, Li L, Matis L. Anti-C5 single chain antibody therapy blocks complement & leukocyte activation and reduces myocardial tissue damage in CPB patients. Molecular Immunology 1998, 35: 397. DOI: 10.1016/s0161-5890(98)90798-2.
- Afifi S, Hashim S, Mathew J, Fontes M, Davis E, Tracey J, Smith B, Rinder C. TISSUE FACTOR PATHWAY INHIBITOR RISES AND MONOCYTE TISSUE FACTOR RESPONSE TO ENDOTOXIN FALLS DURING CPB. Anesthesia & Analgesia 1998, 86: 2sca.. DOI: 10.1213/00000539-199804001-00002.
- Lee D, Smith M, Tracey J, Johnson K, Higgins P, Yeh C, Smith B, Rinder C. C3- AND C5- CONVERTASE INHIBITION PREVENTS MONOCYTE AND PMN ACTIVATION DURING IN VITRO CARDIOPULMONARY BYPASS. Anesthesia & Analgesia 1998, 86: 1sca.. DOI: 10.1213/00000539-199804001-00001.
- Rinder H, Schuster J, Rinder C, Wang C, Schweidler H, Smith B. Correlation of Thrombosis With Increased Platelet Turnover in Thrombocytosis. Blood 1998, 91: 1288-1294. PMID: 9454759, DOI: 10.1182/blood.v91.4.1288.
- Crouch J, Leitenberg D, Smith B, Howe J. Epstein‐Barr virus suspension cell assay using in situ hybridization and flow cytometry. Cytometry 1997, 29: 50-57. PMID: 9298811, DOI: 10.1002/(sici)1097-0320(19970901)29:1<50::aid-cyto5>3.0.co;2-h.
- Rinder C, Mathew J, Rinder H, Tracey J, Davis E, Smith B. Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender. Translational Research 1997, 129: 592-602. PMID: 9178725, DOI: 10.1016/s0022-2143(97)90193-1.
- HARRIS S, RINDER C, RINDER H, TRACEY J, SMITH B, HINES R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Survey Of Anesthesiology 1996, 40: 326. DOI: 10.1097/00132586-199610000-00069.
- Ross G, Erickson R, Knorr D, Motulsky A, Parkman R, Samulski J, Straus S, Smith B. Gene Therapy in the United States: A Five-Year Status Report. Human Gene Therapy 1996, 7: 1781-1790. PMID: 8886849, DOI: 10.1089/hum.1996.7.14-1781.
- Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.
- Leitenberg D, Constant S, Lu D, Smith B, Bottomly K. CD4 and CD45 regulate qualitatively distinct patterns of calcium mobilization in individual CD4+ T cells. European Journal Of Immunology 1995, 25: 2445-2451. PMID: 7589109, DOI: 10.1002/eji.1830250906.
- Leitenberg D, Eisen R, Goldstein J, Busque L, Rinder H, Stys P, Katz M, Gilliland D, Smith B. Natural killer cell lymphoproliferative disease associated with neuropathy. The American Journal Of Medicine 1995, 99: 99-101. PMID: 7598151, DOI: 10.1016/s0002-9343(99)80112-0.
- Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypassMathew J, Rinder C, Tracey J, Auszura L, O'Connor T, Davis E, Smith B. Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass. Journal Of Thoracic And Cardiovascular Surgery 1995, 109: 448-456. PMID: 7877305, DOI: 10.1016/s0022-5223(95)70275-x.
- Leitenberg D, Rappeport J, Smith B. B-Cell Precursor Bone Marrow Reconstitution After Bone Marrow Transplantation. American Journal Of Clinical Pathology 1994, 102: 231-236. PMID: 8042594, DOI: 10.1093/ajcp/102.2.231.
- Buc N, Capron A, Carmen I, Chase G, DeLeon P, Doi R, Dronamraju K, Geiduschek E, Haselkorn R, Hirano S, Krogstad D, Miller A, Motulsky A, Parkman R, Post L, Secundy M, Smith B, Straus S, Walters L, Zallen D. Minutes of the September 910, 1993 Recombinant DNA Advisory Committee Meeting. Human Gene Therapy 1994, 5: 645-660. DOI: 10.1089/hum.1994.5.5-645.
- Rinder H, Tracey J, Rinder C, Leitenberg D, Smith B. Neutrophil but not Monocyte Activation Inhibits P-Selectin-Mediated Platelet Adhesion*. Thrombosis And Haemostasis 1994, 72: 750-756. PMID: 7534948, DOI: 10.1055/s-0038-1648953.
- Rinder C, Gaal D, Student L, Smith B. Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass. Journal Of Thoracic And Cardiovascular Surgery 1994, 107: 280-288. PMID: 8283897, DOI: 10.1016/s0022-5223(94)70482-1.
- Rinder H, Bonan J, Anandan S, Rinder C, Rodrigues P, Smith B. Noninvasive measurement of platelet kinetics in normal and hypertensive pregnancies. American Journal Of Obstetrics And Gynecology 1994, 170: 117-122. DOI: 10.1016/s0002-9378(13)70291-6.
- Bonan J, Rinder H, Smith B. Determination of the percentage of thiazole orange (TO)‐positive, “reticulated” platelets using autologous erythrocyte TO fluorescence as an internal standard. Cytometry 1993, 14: 690-694. PMID: 8404376, DOI: 10.1002/cyto.990140615.
- Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin Does Not Inhibit Adenosine Diphosphate-Induced Platelet α-Granule Release. Blood 1993, 82: 505-512. PMID: 7687162, DOI: 10.1182/blood.v82.2.505.505.
- Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin does not inhibit adenosine diphosphate-induced platelet alpha- granule release. Blood 1993, 82: 505-512. DOI: 10.1182/blood.v82.2.505.bloodjournal822505.
- SMITH B. Integrating Flow Cytometry in the Hematology Laboratory. Annals Of The New York Academy Of Sciences 1993, 677: 326-333. PMID: 8494218, DOI: 10.1111/j.1749-6632.1993.tb38787.x.
- SMITH B. Qualitative versus Quantitative Immunophenotypinga. Annals Of The New York Academy Of Sciences 1993, 677: 152-154. PMID: 8494204, DOI: 10.1111/j.1749-6632.1993.tb38773.x.
- Macklis R, Mauch P, Thompson L, Burakoff S, Smith B. Phenotypic and Functional Analysis of Expanded Natural Killer Cell Subpopulations in Hodgkin’s Disease Patients Treated with Lymphoid Irradiation. Oncology 1993, 50: 323-328. PMID: 8497384, DOI: 10.1159/000227203.
- Wiebe V, Smith B, DeGregorio M, Rappeport J. Pharmacology of agents used in bone marrow transplant conditioning regimens. Critical Reviews In Oncology/Hematology 1992, 13: 241-270. PMID: 1476655, DOI: 10.1016/1040-8428(92)90092-5.
- Gaal D, Rinder C, Student L, Smith B. CELLULAR ACTIVATION ON PEDIATRIC CPB. Anesthesiology 1992, 77: a1137. DOI: 10.1097/00000542-199209001-01137.
- Maziarz R, Arced R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A γδ+ T-Cell Leukemia Bearing a Novel t(8;14)(q24;q11) Translocation Demonstrates Spontaneous In Vitro Natural Killer-Like Activity. Blood 1992, 79: 1523-1531. DOI: 10.1182/blood.v79.6.1523.1523.
- Maziarz R, Arceci R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity. Blood 1992, 79: 1523-31. PMID: 1532137, DOI: 10.1182/blood.v79.6.1523.bloodjournal7961523.
- Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion. Blood 1992, 79: 1201-1205. PMID: 1371416, DOI: 10.1182/blood.v79.5.1201.1201.
- Smith BR. Can medical rationing be made rational? Archives Of Internal Medicine 1992, 152: 476-7. PMID: 1546908.
- Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992, 79: 1201-1205. DOI: 10.1182/blood.v79.5.1201.bloodjournal7951201.
- Antin J, Bierer B, Smith B, Ferrara J, Guinan E, Sieff C, Golan D, Macklis R, Tarbell N, Lynch E, Reichert T, Blythman H, Bouloux C, Rappeport J, Burakoff S, Weinstein H. Selective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies. Blood 1991, 78: 2139-2149. PMID: 1717080, DOI: 10.1182/blood.v78.8.2139.2139.
- Antin J, Bierer B, Smith B, Ferrara J, Guinan E, Sieff C, Golan D, Macklis R, Tarbell N, Lynch E. Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies. Blood 1991, 78: 2139-2149. DOI: 10.1182/blood.v78.8.2139.bloodjournal7882139.
- Rinder C, Mathew J, Rinder H, Bonan J, Ault K, Smith B. Modulation of Platelet Surface Adhesion Receptors during Cardiopulmonary Bypass. Anesthesiology 1991, 75: 563-570. PMID: 1718190, DOI: 10.1097/00000542-199110000-00004.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Dynamics of leukocyte-platelet adhesion in whole blood. Blood 1991, 78: 1730-7. PMID: 1717069, DOI: 10.1182/blood.v78.7.1730.bloodjournal7871730.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Activated and unactivated platelet adhesion to monocytes and neutrophils. Blood 1991, 78: 1760-9. PMID: 1717070, DOI: 10.1182/blood.v78.7.1760.bloodjournal7871760.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Dynamics of Leukocyte-Platelet Adhesion in Whole Blood. Blood 1991, 78: 1730-1737. DOI: 10.1182/blood.v78.7.1730.1730.
- Rinder H, Bonan J, Rinder C, Ault K, Smith B. Activated and Unactivated Platelet Adhesion to Monocytes and Neutrophils. Blood 1991, 78: 1760-1769. DOI: 10.1182/blood.v78.7.1760.1760.
- Rinder C, Hathew J, Bonan J, Smith B. PLATELET–LEUKOCYTE BINDING ON CARDIOPULMONARY BYPASS. Anesthesiology 1991, 75: a58. DOI: 10.1097/00000542-199109001-00058.
- Rinder C, Mathew J, Bonan J, Hines R, Smith B. CPB INDUCES INCREASED LEUKOCYTE ADHESION RECEPTORS BUT NOT TNF-α. Anesthesiology 1991, 75: a59. DOI: 10.1097/00000542-199109001-00059.
- Strair R, Towle M, Heald P, Smith B. Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells: assaying for a viral transactivator activity in normal and malignant cells. Blood 1990, 76: 1201-8. PMID: 2144777, DOI: 10.1182/blood.v76.6.1201.bloodjournal7661201.
- Strair R, Towle M, Heald P, Smith B. Retroviral Mediated Transfer and Expression of Exogenous Genes in Primary Lymphoid Cells: Assaying for a Viral Transactivator Activity in Normal and Malignant Cells. Blood 1990, 76: 1201-1208. DOI: 10.1182/blood.v76.6.1201.1201.
- Rinder C, Rinder H, Ault K, Smith B. A74 PLATELET RECEPTORS FOR ADHESIVE LIGANDS ARE DECREASED DURING CARDIOPULMONARY BYPASS. Anesthesiology 1990, 73: na. DOI: 10.1097/00000542-199009001-00074.
- Strair R, Towle M, Smith B. Retroviral mediated gene transfer into bone marrow progenitor cells: use of beta-galactosidase as a selectable marker. Nucleic Acids Research 1990, 18: 4759-4762. PMID: 2118622, PMCID: PMC331937, DOI: 10.1093/nar/18.16.4759.
- Mitus A, Stein R, Rappeport J, Antin J, Weinstein H, Alper C, Smith B. Monoclonal and oligoclonal gammopathy after bone marrow transplantation. Blood 1989, 74: 2764-8. PMID: 2819246, DOI: 10.1182/blood.v74.8.2764.bloodjournal7482764.
- Mitus A, Stein R, Rappeport J, Antin J, Weinstein H, Alper C, Smith B. Monoclonal and Oligoclonal Gammopathy After Bone Marrow Transplantation. Blood 1989, 74: 2764-2768. DOI: 10.1182/blood.v74.8.2764.2764.
- Niemeyer C, Sieff C, Smith B, Ault K, Nathan D. Hematopoiesis in vitro coexists with natural killer lymphocytes. Blood 1989, 74: 2376-82. PMID: 2529928, DOI: 10.1182/blood.v74.7.2376.bloodjournal7472376.
- Niemeyer C, Sieff C, Smith B, Ault K, Nathan D. Hematopoiesis In Vitro Coexists With Natural Killer Lymphocytes. Blood 1989, 74: 2376-2382. DOI: 10.1182/blood.v74.7.2376.2376.
- Ibrahim R, Teich D, Smith B, Antin J, Olivier A, Weinberg D. Flow cytometric surface light chain analysis of lymphocyte‐rich effusions. A useful adjunct to cytologic diagnosis. Cancer 1989, 63: 2024-2029. PMID: 2495164, DOI: 10.1002/1097-0142(19890515)63:10<2024::aid-cncr2820631026>3.0.co;2-h.
- Bierer B, Burakoff S, Smith B. A large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation. Blood 1989, 73: 1359-66. PMID: 2467708, DOI: 10.1182/blood.v73.5.1359.bloodjournal7351359.
- Bierer B, Burakoff S, Smith B. A Large Proportion of T Lymphocytes Lack CD5 Expression After Bone Marrow Transplantation. Blood 1989, 73: 1359-1366. DOI: 10.1182/blood.v73.5.1359.1359.
- Guinan E, Smith B, Doukas J, Miller R, Pober J. Vascular endothelial cells enhance T cell responses by markedly augmenting IL-2 concentrations. Cellular Immunology 1989, 118: 166-177. PMID: 2562928, DOI: 10.1016/0008-8749(89)90366-3.
- Bierer B, Emerson S, Antin J, Maziarz R, Rappeport J, Smith B, Burakoff A. REGULATION OF CYTOTOXIC T LYMPHOCYTE-MEDIATED GRAFT REJECTION FOLLOWING BONE MARROW. Transplantation 1988, 46: 835-839. PMID: 3061078, DOI: 10.1097/00007890-198812000-00009.
- Antin J, Smith B, Holmes W, Rosenthal D. Phase I/II study of recombinant human granulocyte-macrophage colony-stimulating factor in aplastic anemia and myelodysplastic syndrome. Blood 1988, 72: 705-13. PMID: 3042046, DOI: 10.1182/blood.v72.2.705.bloodjournal722705.
- Antin J, Smith B, Holmes W, Rosenthal D. Phase I/II Study of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Aplastic Anemia and Myelodysplastic Syndrome. Blood 1988, 72: 705-713. DOI: 10.1182/blood.v72.2.705.705.
- Daley J, Rozans M, Smith B, Burakoff S, Rappeport J, Miller R. Retarded recovery of functional T cell frequencies in T cell-depleted bone marrow transplant recipients. Blood 1987, 70: 960-4. PMID: 3307954, DOI: 10.1182/blood.v70.4.960.bloodjournal704960.
- Daley J, Rozans M, Smith B, Burakoff S, Rappeport J, Miller R. Retarded Recovery of Functional T Cell Frequencies in T Cell–Depleted Bone Marrow Transplant Recipients. Blood 1987, 70: 960-964. DOI: 10.1182/blood.v70.4.960.960.
- Rozans M, Smith B, Emerson S, Crimmins M, Laurent G, Reichert T, Burakoff S, Miller R. FUNCTIONAL ASSESSMENT OF T CELL DEPLETION FROM BONE MARROW PRIOR TO THERAPEUTIC TRANSPLANTATION USING LIMITING DILUTION CULTURE METHODS. Transplantation 1986, 42: 380-386. PMID: 3094209, DOI: 10.1097/00007890-198610000-00010.
- Patenaude A, Rappeport J, Smith B. The physician's influence on informed consent for bone marrow transplantation. Theoretical Medicine And Bioethics 1986, 7: 165-179. PMID: 3526626, DOI: 10.1007/bf00489228.
- Antin J, Smith B, Ewenstein B, Arceci R, Lipton J, Page P, Rappeport J. HTLV-III Infection After Bone Marrow Transplantation. Blood 1986, 67: 160-163. DOI: 10.1182/blood.v67.1.160.160.
- Antin J, Ginsburg D, Smith B, Nathan D, Orkin S, Rappeport J. Bone Marrow Transplantation for Paroxysmal Nocturnal Hemoglobinuria: Eradication of the PNH Clone and Documentation of Complete Lymphohematopoietic Engraftment. Blood 1985, 66: 1247-1250. DOI: 10.1182/blood.v66.6.1247.1247.
- Louie E, Ault K, Smith B, Hardman E, Quesenberry P. IgG‐mediated haemolysis masquerading as cold agglutinin‐induced anaemia complicating severe infection with Mycoplasma pneumoniae. European Journal Of Haematology 1985, 35: 264-269. PMID: 3933104, DOI: 10.1111/j.1600-0609.1985.tb01705.x.
- First L, Smith B, Lipton J, Nathan D, Parkman R, Rappeport J. Isolated Thrombocytopenia After Allogeneic Bone Marrow Transplantation: Existence of Transient and Chronic Thrombocytopenic Syndromes. Blood 1985, 65: 368-374. DOI: 10.1182/blood.v65.2.368.368.
- Smith B, Weinberg D, Robert N, Towle M, Luther E, Pinkus G, Ault K. Circulating Monoclonal B Lymphocytes in Non-Hodgkin's Lymphoma. New England Journal Of Medicine 1984, 311: 1476-1481. PMID: 6438505, DOI: 10.1056/nejm198412063112304.
- Parkman R, Rappeport J, Hellman S, Lipton J, Smith B, Geha R, Nathan D. Busulfan and Total Body Irradiation as Antihematopoietic Stem Cell Agents in the Preparation of Patients With Congenital Bone Marrow Disorders for Allogeneic Bone Marrow Transplantation. Blood 1984, 64: 852-857. DOI: 10.1182/blood.v64.4.852.852.
- First L, Smith B, Lipton J, Nathan D, Parkman R, Rappeport J. ISOLATED THROMBOCYTOPENIA FOLLOWING ALLOGENEIC BONE MARROW TRANSPLANTATION. Pediatric Research 1984, 18: 240-240. DOI: 10.1203/00006450-198404001-00880.
- Rappeport J, Smith B, Parkman R, Rosen F. Application of bone marrow transplantation in genetic diseases. Clinics In Haematology 1983, 12: 755-773. PMID: 6416728, DOI: 10.1016/s0308-2261(83)80009-5.
- Bloch D, Smith B, Ault K. Cells on microspheres: A new technique for flow cytometric analysis of adherent cells. Cytometry 1983, 3: 449-452. PMID: 6343013, DOI: 10.1002/cyto.990030611.
- Smith B, Robert N, Ault K. In Waldenstrom's Macroglobulinemia the Quantity of Detectable Circulating Monoclonal B Lymphocytes Correlates With Clinical Course. Blood 1983, 61: 911-914. DOI: 10.1182/blood.v61.5.911.911.