- Yale Infectious DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510
Barbara Kazmierczak, PhD, MD
Infectious Diseases
Telehealth is available
Patient type treated
Adult
Accepting new patients
No
Referral required
Not Applicable
Titles
- Gustavus and Louise Pfeiffer Research Foundation M.D.-Ph.D. Program Director and Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis
- Professor, Microbial Pathogenesis
- Director, MD-PhD Program, Yale University
Education & Training
- Assistant Adjunct ProfessorUniversity of California, San Francisco (2001)
- FellowUniversity of California, San Francisco (1999)
- ResidentUniversity of California, San Francisco (1996)
- InternUniversity of California, San Francisco (1995)
- MDCornell University Medical College (1994)
- PhDRockefeller University (1993)
- BAUniversity of Chicago (1986)
- MSUniversity of Chicago (1986)
Languages Spoken
- English
- Polski (Polish)
Additional Information
Honors & Recognitions
- Elected Member, AAM: American Academy for Microbiology (2019)
- Distinguished Lecturer: American Society for Microbiology (2018)
- Elected Member, ASCI: American Society for Clinical Investigation (2014)
- Visiting Faculty Research Grant: Deutscher Akademischer Austausch Dienst (DAAD) (2010)
- Elected Member: Polish Institute of Arts and Sciences in America (2009)
- Fellow, IDSA: Infectious Diseases Society of America (2008)
- Investigator in Pathogenesis of Infectious Diseases: Burroughs Wellcome Fund (2007)
- Investigator Award: Patrick and Catherine Weldon Donaghue Medical Research Foundation (2003)
Professional Service
- MD-PhD Steering Committee, GREAT Group, AAMC (2017 - Present)
- Yale University (2010 - 2014): Associate Director for Basic Research, MD-PhD Program
- IDSA (2009 - 2012): Annual Meeting Planning Committee
- Director of Admissions, Microbiology Program, Yale University (2004 - 2007)
- Yale University (2004 - Present): MD/PhD Faculty Committee
Publications
- Lin CK, Lee DSW, McKeithen-Mead S, Emonet T, Kazmierczak B. A Primed Subpopulation of Bacteria Enables Rapid Expression of the Type 3 Secretion System in Pseudomonas aeruginosa. MBio 2021, 12: e0083121. PMID: 34154400, PMCID: PMC8262847, DOI: 10.1128/mBio.00831-21.
- Rundell EA, Commodore N, Goodman AL, Kazmierczak BI. A Screen for Antibiotic Resistance Determinants Reveals a Fitness Cost of the Flagellum in Pseudomonas aeruginosa. Journal Of Bacteriology 2020, 202 PMID: 31871033, PMCID: PMC7043666, DOI: 10.1128/JB.00682-19.
- Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. Global chemical effects of the microbiome include new bile-acid conjugations. Nature 2020, 579: 123-129. PMID: 32103176, PMCID: PMC7252668, DOI: 10.1038/s41586-020-2047-9.
- Kazmierczak BI. The Enemy of my Enemy: Bacterial Competition in the Cystic Fibrosis Lung. Cell Host & Microbe 2020, 28: 502-504. PMID: 33031766, DOI: 10.1016/j.chom.2020.09.009.
- Zhu S, Schniederberend M, Zhitnitsky D, Jain R, Galán JE, Kazmierczak BI, Liu J. In Situ Structures of Polar and Lateral Flagella Revealed by Cryo-Electron Tomography. Journal Of Bacteriology 2019, 201 PMID: 31010901, PMCID: PMC6560136, DOI: 10.1128/JB.00117-19.
- Schniederberend M, Williams JF, Shine E, Shen C, Jain R, Emonet T, Kazmierczak BI. Modulation of flagellar rotation in surface-attached bacteria: A pathway for rapid surface-sensing after flagellar attachment. PLoS Pathogens 2019, 15: e1008149. PMID: 31682637, PMCID: PMC6855561, DOI: 10.1371/journal.ppat.1008149.
- Jain R, Sliusarenko O, Kazmierczak BI. Interaction of the cyclic-di-GMP binding protein FimX and the Type 4 pilus assembly ATPase promotes pilus assembly. PLoS Pathogens 2017, 13: e1006594. PMID: 28854278, PMCID: PMC5595344, DOI: 10.1371/journal.ppat.1006594.
- Lin CK, Kazmierczak BI. Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection. Journal Of Innate Immunity 2017, 9: 250-261. PMID: 28222444, PMCID: PMC5469373, DOI: 10.1159/000455857.
- Rundell EA, McKeithen-Mead SA, Kazmierczak BI. Rampant Cheating by Pathogens? PLoS Pathogens 2016, 12: e1005792. PMID: 27606630, PMCID: PMC5015830, DOI: 10.1371/journal.ppat.1005792.
- Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE. NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. The Journal Of Experimental Medicine 2016, 213: 657-65. PMID: 27045008, PMCID: PMC4854734, DOI: 10.1084/jem.20151809.
- Kazmierczak BI, Schniederberend M, Jain R. Cross-regulation of Pseudomonas motility systems: the intimate relationship between flagella, pili and virulence. Current Opinion In Microbiology 2015, 28: 78-82. PMID: 26476804, PMCID: PMC4688086, DOI: 10.1016/j.mib.2015.07.017.
- Romberg N, Al Moussawi K, Nelson-Williams C, Stiegler AL, Loring E, Choi M, Overton J, Meffre E, Khokha MK, Huttner AJ, West B, Podoltsev NA, Boggon TJ, Kazmierczak BI, Lifton RP. Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Nature Genetics 2014, 46: 1135-1139. PMID: 25217960, PMCID: PMC4177367, DOI: 10.1038/ng.3066.
- Al Moussawi K, Kazmierczak BI. Distinct contributions of interleukin-1α (IL-1α) and IL-1β to innate immune recognition of Pseudomonas aeruginosa in the lung. Infection And Immunity 2014, 82: 4204-11. PMID: 25069982, PMCID: PMC4187872, DOI: 10.1128/IAI.02218-14.
- Czechowska K, McKeithen-Mead S, Al Moussawi K, Kazmierczak BI. Cheating by type 3 secretion system-negative Pseudomonas aeruginosa during pulmonary infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 7801-6. PMID: 24821799, PMCID: PMC4040582, DOI: 10.1073/pnas.1400782111.
- Schniederberend M, Abdurachim K, Murray TS, Kazmierczak BI. The GTPase activity of FlhF is dispensable for flagellar localization, but not motility, in Pseudomonas aeruginosa. Journal Of Bacteriology 2013, 195: 1051-60. PMID: 23264582, PMCID: PMC3571332, DOI: 10.1128/JB.02013-12.
- Gallagher EJ, Rockey DC, Kontos CD, Vyas JM, Brass LF, Hu PJ, Isales CM, Ajijola OA, Rathmell WK, Conlin PR, Baiocchi RA, Kazmierczak BI, Akabas MH, Williams CS. Pearls of wisdom for aspiring physician-scientist residency applicants and program directors. JCI Insight 2022, 7 PMID: 35315364, PMCID: PMC8986063, DOI: 10.1172/jci.insight.158467.
Patient Care Organizations
Titles
- Gustavus and Louise Pfeiffer Research Foundation M.D.-Ph.D. Program Director and Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis
- Professor, Microbial Pathogenesis
- Director, MD-PhD Program, Yale University
Education & Training
- Assistant Adjunct ProfessorUniversity of California, San Francisco (2001)
- FellowUniversity of California, San Francisco (1999)
- ResidentUniversity of California, San Francisco (1996)
- InternUniversity of California, San Francisco (1995)
- MDCornell University Medical College (1994)
- PhDRockefeller University (1993)
- BAUniversity of Chicago (1986)
- MSUniversity of Chicago (1986)
Languages Spoken
- English
- Polski (Polish)
Additional Information
Honors & Recognitions
- Elected Member, AAM: American Academy for Microbiology (2019)
- Distinguished Lecturer: American Society for Microbiology (2018)
- Elected Member, ASCI: American Society for Clinical Investigation (2014)
- Visiting Faculty Research Grant: Deutscher Akademischer Austausch Dienst (DAAD) (2010)
- Elected Member: Polish Institute of Arts and Sciences in America (2009)
- Fellow, IDSA: Infectious Diseases Society of America (2008)
- Investigator in Pathogenesis of Infectious Diseases: Burroughs Wellcome Fund (2007)
- Investigator Award: Patrick and Catherine Weldon Donaghue Medical Research Foundation (2003)
Professional Service
- MD-PhD Steering Committee, GREAT Group, AAMC (2017 - Present)
- Yale University (2010 - 2014): Associate Director for Basic Research, MD-PhD Program
- IDSA (2009 - 2012): Annual Meeting Planning Committee
- Director of Admissions, Microbiology Program, Yale University (2004 - 2007)
- Yale University (2004 - Present): MD/PhD Faculty Committee
Publications
- Lin CK, Lee DSW, McKeithen-Mead S, Emonet T, Kazmierczak B. A Primed Subpopulation of Bacteria Enables Rapid Expression of the Type 3 Secretion System in Pseudomonas aeruginosa. MBio 2021, 12: e0083121. PMID: 34154400, PMCID: PMC8262847, DOI: 10.1128/mBio.00831-21.
- Rundell EA, Commodore N, Goodman AL, Kazmierczak BI. A Screen for Antibiotic Resistance Determinants Reveals a Fitness Cost of the Flagellum in Pseudomonas aeruginosa. Journal Of Bacteriology 2020, 202 PMID: 31871033, PMCID: PMC7043666, DOI: 10.1128/JB.00682-19.
- Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. Global chemical effects of the microbiome include new bile-acid conjugations. Nature 2020, 579: 123-129. PMID: 32103176, PMCID: PMC7252668, DOI: 10.1038/s41586-020-2047-9.
- Kazmierczak BI. The Enemy of my Enemy: Bacterial Competition in the Cystic Fibrosis Lung. Cell Host & Microbe 2020, 28: 502-504. PMID: 33031766, DOI: 10.1016/j.chom.2020.09.009.
- Zhu S, Schniederberend M, Zhitnitsky D, Jain R, Galán JE, Kazmierczak BI, Liu J. In Situ Structures of Polar and Lateral Flagella Revealed by Cryo-Electron Tomography. Journal Of Bacteriology 2019, 201 PMID: 31010901, PMCID: PMC6560136, DOI: 10.1128/JB.00117-19.
- Schniederberend M, Williams JF, Shine E, Shen C, Jain R, Emonet T, Kazmierczak BI. Modulation of flagellar rotation in surface-attached bacteria: A pathway for rapid surface-sensing after flagellar attachment. PLoS Pathogens 2019, 15: e1008149. PMID: 31682637, PMCID: PMC6855561, DOI: 10.1371/journal.ppat.1008149.
- Jain R, Sliusarenko O, Kazmierczak BI. Interaction of the cyclic-di-GMP binding protein FimX and the Type 4 pilus assembly ATPase promotes pilus assembly. PLoS Pathogens 2017, 13: e1006594. PMID: 28854278, PMCID: PMC5595344, DOI: 10.1371/journal.ppat.1006594.
- Lin CK, Kazmierczak BI. Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection. Journal Of Innate Immunity 2017, 9: 250-261. PMID: 28222444, PMCID: PMC5469373, DOI: 10.1159/000455857.
- Rundell EA, McKeithen-Mead SA, Kazmierczak BI. Rampant Cheating by Pathogens? PLoS Pathogens 2016, 12: e1005792. PMID: 27606630, PMCID: PMC5015830, DOI: 10.1371/journal.ppat.1005792.
- Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE. NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. The Journal Of Experimental Medicine 2016, 213: 657-65. PMID: 27045008, PMCID: PMC4854734, DOI: 10.1084/jem.20151809.
- Kazmierczak BI, Schniederberend M, Jain R. Cross-regulation of Pseudomonas motility systems: the intimate relationship between flagella, pili and virulence. Current Opinion In Microbiology 2015, 28: 78-82. PMID: 26476804, PMCID: PMC4688086, DOI: 10.1016/j.mib.2015.07.017.
- Romberg N, Al Moussawi K, Nelson-Williams C, Stiegler AL, Loring E, Choi M, Overton J, Meffre E, Khokha MK, Huttner AJ, West B, Podoltsev NA, Boggon TJ, Kazmierczak BI, Lifton RP. Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Nature Genetics 2014, 46: 1135-1139. PMID: 25217960, PMCID: PMC4177367, DOI: 10.1038/ng.3066.
- Al Moussawi K, Kazmierczak BI. Distinct contributions of interleukin-1α (IL-1α) and IL-1β to innate immune recognition of Pseudomonas aeruginosa in the lung. Infection And Immunity 2014, 82: 4204-11. PMID: 25069982, PMCID: PMC4187872, DOI: 10.1128/IAI.02218-14.
- Czechowska K, McKeithen-Mead S, Al Moussawi K, Kazmierczak BI. Cheating by type 3 secretion system-negative Pseudomonas aeruginosa during pulmonary infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 7801-6. PMID: 24821799, PMCID: PMC4040582, DOI: 10.1073/pnas.1400782111.
- Schniederberend M, Abdurachim K, Murray TS, Kazmierczak BI. The GTPase activity of FlhF is dispensable for flagellar localization, but not motility, in Pseudomonas aeruginosa. Journal Of Bacteriology 2013, 195: 1051-60. PMID: 23264582, PMCID: PMC3571332, DOI: 10.1128/JB.02013-12.
- Gallagher EJ, Rockey DC, Kontos CD, Vyas JM, Brass LF, Hu PJ, Isales CM, Ajijola OA, Rathmell WK, Conlin PR, Baiocchi RA, Kazmierczak BI, Akabas MH, Williams CS. Pearls of wisdom for aspiring physician-scientist residency applicants and program directors. JCI Insight 2022, 7 PMID: 35315364, PMCID: PMC8986063, DOI: 10.1172/jci.insight.158467.
Patient Care Organizations
- Yale Infectious DiseasesYale New Haven Hospital20 York StreetNew Haven, CT 06510