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When Long COVID Worsens Preexisting Chronic Conditions

BY Rhys Richmond November 11, 2024

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Research reports and detailed case studies from doctors and other providers can tell us a lot about Long COVID. But to understand the full scope of the disease and its impact, we must also listen to the experiences of patients who are suffering.

Today’s post features a contribution from one of our readers, who details his experience with Long COVID and a preexisting illness—in his case, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). As someone who suffers from both ME/CFS and Long COVID, Billy Hanlon—in his role as the director of advocacy and outreach at the Minnesota ME/CFS Alliance—also advocates for advancing research into these conditions.

While researchers and clinicians have noted parallels between ME/CFS and Long COVID, as well as among other post-acute infection syndromes, much more research is needed to fill the knowledge gaps. Some researchers hypothesize that multi-organ damage wreaked by COVID-19 might explain how people with preexisting disease in certain organs (such as the heart, lung, liver, and kidney) might be at higher risk of severe COVID-19 affecting those same organs. Furthermore, research has linked an increased risk of developing post-acute sequelae of COVID-19 (Long COVID) to having a preexisting medical condition prior to SARS-CoV-2 infection

In a sense, we’re beginning to see that COVID-19 infections might take advantage of less-than-perfect health to cause persistent symptoms. While other viruses have exhibited similar opportunistic patterns—for example, influenza has been shown to cause more severe illness and hospitalizations in patients with obesity and heart disease—the long-lasting and poorly understood manifestations of Long COVID merit particular attention. In Hanlon’s account below of his own struggles with ME/CFS and Long COVID, he also details how you may be able to help advocate for more research into both of these conditions.

Read other installments of Long COVID Dispatches here.

If you’d like to share your experience with Long COVID for possible use in this blog (under a pseudonym), write to us at: LongCovidDispatches@yale.edu. It may appear, space permitting, in a future post.

Information provided in Yale Medicine content is for general informational purposes only. It should never be used as a substitute for medical advice from your doctor or other qualified clinician. Always seek the individual advice of your health care provider for any questions you have regarding a medical condition.