Pallavi Gopal is a graduate of the Medical Scientist Training Program at the University of Pennsylvania, Perelman School of Medicine in Philadelphia. Her Ph.D. thesis work in Neuroscience with Dr. Jeffrey Golden focused on understanding the cellular and molecular mechanisms that guide neuronal migration during forebrain development. After earning her M.D., Pallavi completed postgraduate clinical training in Anatomic Pathology and Neuropathology at the Hospital of the University of Pennsylvania. She did her postdoctoral research training with Dr. Erika Holzbaur at the University of Pennsylvania. Dr. Gopal is a recipient of the NINDS Clinical Scientist Research Career Development Award. She joined the Pathology Department at Yale School of Medicine in January 2018.
The Gopal lab is broadly interested in mRNA transport, RNA metabolism and its regulation in healthy and diseased neurons. As a physician-scientist, Dr. Gopal’s research aims to bridge neuronal cell biology and neuropathology of neurodegenerative disease. Her post-doctoral research provided new insight into the biophysical properties of neuronal ribonucleoprotein (RNP) granules and has shown that ALS-linked mutations fundamentally perturb the dynamic properties and transport of neuronal RNP complexes. The focus of the Gopal lab is to elucidate the molecular mechanisms driving neuronal RNP granule assembly, the spatiotemporal maturation and function of diverse RNP granules in neuronal physiology, and pathologic transitions in disease.