Pain, Silent Cerebral Infarcts, and Cognition in Adults with Sickle Cell Disease (Pain+SCAN) study
- Study HIC#:2000037807
- Last Updated:08/20/2025
The purpose of this research study is to understand the relationship between sickle cell-related pain, cognition (the way you think), and silent cerebral infarcts (which are blockages of small vessels in the brain, that do not cause noticeable physical changes. That is why they are referred to as silent) in adults with sickle cell disease (SCD).
If you enroll in the study, you will be asked to: take a cognitive assessment, fill out a pain diary for 14 days, answer questionnaires about your sickle cell pain, and get a Brain MRI.
Compensation of $50 total will be provided.
Contact Us
For more information about this study, including how to volunteer, contact:
Dr. Jennifer Afranie-Sakyi, MD (PI)
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call +18779788343 for more information.
Eligibility Criteria
Inclusion Criteria
- Adults with SCD, ages 18 or older
- Any SCD genotype (confirmed by electrophoresis)
Exclusion Criteria
- Under age 18
- History of stroke or epilepsy or cerebral vasculopathy
- Prior established diagnosis of developmental delay or other cognitive impairment
- On chronic red cell transfusions
- Currently pregnant
- Unable or unwilling to obtain MR neuroimaging
