Left vs Left RCT
- Study HIC#:2000035059
- Last Updated:11/18/2025
Cardiac-resynchronization therapy (CRT) is a type of heart failure (HF) treatment and is helpful in patients with both reduced ejection fraction (weak heart) and conduction system abnormalities (electricity flow throughout the heart is slow or occurs through abnormal pathways). CRT can be delivered by pacing in one of two different configurations: biventricular pacing (BiVP) or pacing at a place called the His or left bundle branch (His/LBBP). The purpose of this study is to compare BiVP with His/LBBP.
Contact Us
For more information about this study, including how to volunteer, contact:
Margaret Leiss
- Phone Number: 1-203-737-7022
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You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call +18779788343 for more information.
Trial Purpose and Description
The purpose of this study is to test the comparative effectiveness of His/LBBP in relation to patient centered outcomes (QoL, physical activity, HF hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g., lead dislodgement, infection) relative to standard of care BiVP in patients with HF due to left ventricular systolic dysfunction (LVEF 50%) and with either a wide QRS ( 130 ms) or with/anticipated > 40% pacing who are already receiving current standard HF pharmacological therapy.
Eligibility Criteria
To be eligible to take part in this study, you will have to be stable on medications for heart failure therapy and meet the criteria for a CRT device, determined by your doctor.
