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Evaluating the Immune Response to COVID-19 Vaccination in B-cell Depleted Patients

  • Study HIC#:2000029889
  • Last Updated:02/22/2024

You may be eligible to participate in a free and confidential research study investigating how individuals taking immune medications respond to COVID19 vaccination. The Yale MS Center is looking for volunteers who:

  • Are 18 years old or older
  • Are planning to get vaccinated against COVID19 when able to do so
  • Meet one of the following criteria:
    • have multiple sclerosis
    • have an autoimmune blistering disease
    • healthy individuals
  • For patients with autoimmune diseases, must be EITHER:
    • taking rituximab or ocrelizumab
    • taking no immune medications


Study participants will donate blood five times over a timeframe of 6 months. The first blood draw would occur before the first COVID19 vaccination. Some participants will also undergo skin biopsies. All participants will complete surveys to evaluate any symptoms they may experience. Immune cells will be studied in the laboratory to help us better understand how individuals taking B-cell depleting medications respond to COVID19 vaccination. Participants will be compensated.

  • Age18 years and older
  • GenderBoth

Contact Us

For more information about this study, including how to volunteer, contact:

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You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact, or call +18779788343 for more information.

Eligibility Criteria

Inclusion Criteria: 

  • Adult patients only

Principal Investigator

For more information about this study, including how to volunteer, contact: