Richard Young, MD
Pediatrics, Pediatric Neurology
Titles
- Medical Services Provider
- Assoc Clin Prof Pediatrics & Neurology
Education & Training
- FellowshipMassachusetts General Hospital (1980)
- ResidencyMassachusetts General Hospital (1977)
- InternshipUniversity of Washington (1974)
- MDYale University (1973)
Additional Information
Board Certifications
- AB of Psychiatry & Neurology, Neurology with Special Qual in Child Neurology (1983)
- AB of Pediatrics, Pediatrics (1979)
Publications
- Kilgore H, Moreno S, Young R. Protein codes and mobility together shape cellular function and disease. Trends In Biochemical Sciences 2025 PMID: 41318327, PMCID: PMC12703758, DOI: 10.1016/j.tibs.2025.10.009.
- Morelli E, Aktas-Samur A, Maisano D, Gao C, Favasuli V, Papaioannou D, De Nola G, Henninger J, Liu N, Turi M, Folino P, Vreux L, Cumerlato M, Chen L, Aifantis I, Fulciniti M, Anderson K, Lytton-Jean A, Gulla A, Young R, Samur M, Munshi N. CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs. Blood 2025, 146: 847-860. PMID: 40403231, DOI: 10.1182/blood.2025028746.
- Liu Y, Whitfield T, Bell G, Guo R, Flamier A, Young R, Jaenisch R. Exploring the complexity of MECP2 function in Rett syndrome. Nature Reviews Neuroscience 2025, 26: 379-398. PMID: 40360671, DOI: 10.1038/s41583-025-00926-1.
- Kilgore H, Chinn I, Mikhael P, Mitnikov I, Van Dongen C, Zylberberg G, Afeyan L, Banani S, Wilson-Hawken S, Lee T, Barzilay R, Young R. Protein codes promote selective subcellular compartmentalization. Science 2025, 387: 1095-1101. PMID: 39913643, PMCID: PMC12034300, DOI: 10.1126/science.adq2634.
- Gallagher M, Du W, Hazel K, Aydin Z, Cheng Y, Yuan B, Bell G, Young R, Jaenisch R, Corradin O. Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis. Alzheimer's & Dementia 2024, 20: e093591. PMCID: PMC11710746, DOI: 10.1002/alz.093591.
- Dall'Agnese A, Zheng M, Moreno S, Platt J, Hoang A, Kannan D, Dall'Agnese G, Overholt K, Sagi I, Hannett N, Erb H, Corradin O, Chakraborty A, Lee T, Young R. Proteolethargy is a pathogenic mechanism in chronic disease. Cell 2024, 188: 207-221.e30. PMID: 39610243, PMCID: PMC11724756, DOI: 10.1016/j.cell.2024.10.051.
- Henninger J, Young R. An RNA-centric view of transcription and genome organization. Molecular Cell 2024, 84: 3627-3643. PMID: 39366351, PMCID: PMC11495847, DOI: 10.1016/j.molcel.2024.08.021.
- Han T, Portz B, Young R, Boija A, Klein I. RNA and condensates: Disease implications and therapeutic opportunities. Cell Chemical Biology 2024, 31: 1593-1609. PMID: 39303698, DOI: 10.1016/j.chembiol.2024.08.009.
- Liu Y, Flamier A, Bell G, Diao A, Whitfield T, Wang H, Wu Y, Schulte F, Friesen M, Guo R, Mitalipova M, Liu X, Vos S, Young R, Jaenisch R. MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons. Neuron 2024, 112: 1943-1958.e10. PMID: 38697112, DOI: 10.1016/j.neuron.2024.04.007.
- Rossmann M, Yang S, Abraham B, Wang Y, Young R, Hekimi S, Zon L. TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation. Blood 2023, 142: 8. DOI: 10.1182/blood-2023-184853.
- Conditional Mutations Occur Predominantly in Highly Conserved Residues of RNA Polymerase II SubunitsScafe C, Martin C, Nonet M, Podos S, Okamura S, Young R. Conditional Mutations Occur Predominantly in Highly Conserved Residues of RNA Polymerase II Subunits. Molecular And Cellular Biology 1990, 10: 1270-1275. DOI: 10.1128/mcb.10.3.1270-1275.1990.
- Woychik N, Young R. RNA Polymerase II Subunit RPB4 Is Essential for High- and Low-Temperature Yeast Cell Growth. Molecular And Cellular Biology 1989, 9: 2854-2859. DOI: 10.1128/mcb.9.7.2854-2859.1989.
Departments and Programs
Titles
- Medical Services Provider
- Assoc Clin Prof Pediatrics & Neurology
Education & Training
- FellowshipMassachusetts General Hospital (1980)
- ResidencyMassachusetts General Hospital (1977)
- InternshipUniversity of Washington (1974)
- MDYale University (1973)
Additional Information
Board Certifications
- AB of Psychiatry & Neurology, Neurology with Special Qual in Child Neurology (1983)
- AB of Pediatrics, Pediatrics (1979)
Publications
- Kilgore H, Moreno S, Young R. Protein codes and mobility together shape cellular function and disease. Trends In Biochemical Sciences 2025 PMID: 41318327, PMCID: PMC12703758, DOI: 10.1016/j.tibs.2025.10.009.
- Morelli E, Aktas-Samur A, Maisano D, Gao C, Favasuli V, Papaioannou D, De Nola G, Henninger J, Liu N, Turi M, Folino P, Vreux L, Cumerlato M, Chen L, Aifantis I, Fulciniti M, Anderson K, Lytton-Jean A, Gulla A, Young R, Samur M, Munshi N. CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs. Blood 2025, 146: 847-860. PMID: 40403231, DOI: 10.1182/blood.2025028746.
- Liu Y, Whitfield T, Bell G, Guo R, Flamier A, Young R, Jaenisch R. Exploring the complexity of MECP2 function in Rett syndrome. Nature Reviews Neuroscience 2025, 26: 379-398. PMID: 40360671, DOI: 10.1038/s41583-025-00926-1.
- Kilgore H, Chinn I, Mikhael P, Mitnikov I, Van Dongen C, Zylberberg G, Afeyan L, Banani S, Wilson-Hawken S, Lee T, Barzilay R, Young R. Protein codes promote selective subcellular compartmentalization. Science 2025, 387: 1095-1101. PMID: 39913643, PMCID: PMC12034300, DOI: 10.1126/science.adq2634.
- Gallagher M, Du W, Hazel K, Aydin Z, Cheng Y, Yuan B, Bell G, Young R, Jaenisch R, Corradin O. Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis. Alzheimer's & Dementia 2024, 20: e093591. PMCID: PMC11710746, DOI: 10.1002/alz.093591.
- Dall'Agnese A, Zheng M, Moreno S, Platt J, Hoang A, Kannan D, Dall'Agnese G, Overholt K, Sagi I, Hannett N, Erb H, Corradin O, Chakraborty A, Lee T, Young R. Proteolethargy is a pathogenic mechanism in chronic disease. Cell 2024, 188: 207-221.e30. PMID: 39610243, PMCID: PMC11724756, DOI: 10.1016/j.cell.2024.10.051.
- Henninger J, Young R. An RNA-centric view of transcription and genome organization. Molecular Cell 2024, 84: 3627-3643. PMID: 39366351, PMCID: PMC11495847, DOI: 10.1016/j.molcel.2024.08.021.
- Han T, Portz B, Young R, Boija A, Klein I. RNA and condensates: Disease implications and therapeutic opportunities. Cell Chemical Biology 2024, 31: 1593-1609. PMID: 39303698, DOI: 10.1016/j.chembiol.2024.08.009.
- Liu Y, Flamier A, Bell G, Diao A, Whitfield T, Wang H, Wu Y, Schulte F, Friesen M, Guo R, Mitalipova M, Liu X, Vos S, Young R, Jaenisch R. MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons. Neuron 2024, 112: 1943-1958.e10. PMID: 38697112, DOI: 10.1016/j.neuron.2024.04.007.
- Rossmann M, Yang S, Abraham B, Wang Y, Young R, Hekimi S, Zon L. TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation. Blood 2023, 142: 8. DOI: 10.1182/blood-2023-184853.
- Conditional Mutations Occur Predominantly in Highly Conserved Residues of RNA Polymerase II SubunitsScafe C, Martin C, Nonet M, Podos S, Okamura S, Young R. Conditional Mutations Occur Predominantly in Highly Conserved Residues of RNA Polymerase II Subunits. Molecular And Cellular Biology 1990, 10: 1270-1275. DOI: 10.1128/mcb.10.3.1270-1275.1990.
- Woychik N, Young R. RNA Polymerase II Subunit RPB4 Is Essential for High- and Low-Temperature Yeast Cell Growth. Molecular And Cellular Biology 1989, 9: 2854-2859. DOI: 10.1128/mcb.9.7.2854-2859.1989.
Departments and Programs