Peter D Block, MD, MSc
Hepatology, Gastroenterology, Transplant Hepatology
Next Available Appointment
Call the Care center at 1-877-YALEMDS (1-877-925-3637)
Titles
- Assistant Professor of Medicine (Digestive Diseases)
Education & Training
- Transplant Hepatology FellowNYU Langone Health (2025)
- Gastroenterology & Hepatology FellowYale School of Medicine (2024)
- Resident PhysicianThomas Jefferson University Hospitals (2021)
- MDSidney Kimmel Medical College at Thomas Jefferson University, Medicine (2018)
- MScOxford University, Immunology (2013)
- BAHaverford College, Philosophy (2011)
Additional Information
Board Certifications
- AB of Internal Medicine, Gastroenterology (2024)
- AB of Internal Medicine, Internal Medicine (2021)
Professional Service
- AASLD Hepatitis B Special Interest Group (2025 - Present): Steering Committee member
- Hepatitis B Foundation Emerging Scholars Committee (2022 - Present): Steering Committee member
Publications
- Block SJ, Block PD, Graham CS, Sulkowski M, Wang S, Tu T, Cohen C. Sexual health and young people living with chronic hepatitis B: adopting a treatment as prevention framework. Lancet Gastroenterol Hepatol 2025, 10: 609-612. PMID: 40482651, DOI: 10.1016/S2468-1253(25)00123-2.
- Block P, Assis D. Hepatotoxicity of Chemotherapy and Immune Checkpoint Inhibitors. Clinics In Liver Disease 2025, 29: 483-501. PMID: 40670034, DOI: 10.1016/j.cld.2025.03.006.
- Block TM, Guo JT, Zoulim F, Rice CM, Thio CL, Schneider WM, Alter HJ, Jacobson IM, Gish RG, Block PD, Sulkowski M, Feld JJ, Cohen CA. New potent HBV replication inhibitors for the management of chronic hepatitis B are needed. Nat Rev Gastroenterol Hepatol 2025, 22: 150-151. PMID: 39910374, DOI: 10.1038/s41575-025-01037-z.
- Block P, Lim J. Unmet needs in the clinical management of chronic hepatitis B infection. Journal Of The Formosan Medical Association 2024, 124: 502-507. PMID: 39155176, DOI: 10.1016/j.jfma.2024.08.020.
- Block P, Strazzabosco M, Jaffe A. Approach to immunotherapy for HCC in the liver transplant population. Clinical Liver Disease 2024, 23: e0158. PMID: 38707244, PMCID: PMC11068135, DOI: 10.1097/cld.0000000000000158.
- Block PD, Farrell JJ, Li DK. A Rare Cause of Gastrointestinal Bleeding After Pancreaticoduodenectomy. Gastroenterology 2023, 165: 34-36. PMID: 36592728, DOI: 10.1053/j.gastro.2022.12.022.
- Lin S, Halegoua-DeMarzio D, Block P, Kao Y, Civan J, Shieh F, Song W, Hann H, Su Y. Persistently Elevated HBV Viral-Host Junction DNA in Urine as a Biomarker for Hepatocellular Carcinoma Minimum Residual Disease and Recurrence: A Pilot Study. Diagnostics 2023, 13: 1537. PMID: 37174929, PMCID: PMC10177231, DOI: 10.3390/diagnostics13091537.
- Block P, Lim J. Chronic Hepatitis B Virus: What an Internist Needs to Know Serologic Diagnosis, Treatment Options, and Hepatitis B Virus Reactivation. 2023, 107: 435-447. PMID: 37001946, DOI: 10.1016/j.mcna.2022.12.002.
- Halegoua-DeMarzio D, Hann H, Lin S, Block P, Park G, Civan J, Kao Y, Song W, Su Y. S2905 HBV-Host Junctional Sequences: A Novel Urine Tumor Marker for Recurrent Hepatitis B-Associated Hepatocellular Carcinoma With Low Alpha-Fetoprotein. The American Journal Of Gastroenterology 2022, 117: e1891-e1892. DOI: 10.14309/01.ajg.0000868260.09185.3f.
- Li CJ, Claxton BB, Block P, Reilly S, Manski S, Choudhary C. Acute Esophageal Necrosis Secondary to a Paraesophageal Hernia. Case Rep Gastroenterol 2021, 15: 594-597. PMID: 34616261, DOI: 10.1159/000517235.
- Block P, Shinn B, Kim J, Hann H. Hepatitis B-related hepatocellular carcinoma and stress: untangling the host immune response from clinical outcomes. Hepatic Oncology 2020, 8: hep35. PMID: 33680431, PMCID: PMC7907965, DOI: 10.2217/hep-2020-0028.
- Shieh C, Chalikonda D, Block P, Shinn B, Kistler C. S0178 Elevated Fecal Calprotectin: What Is on the Differential Diagnosis? The American Journal Of Gastroenterology 2020, 115: s68-s68. DOI: 10.14309/01.ajg.0000702760.56825.c6.
- Shieh C, Chalikonda D, Block P, Shinn B, Kistler C. S0229 Gastrointestinal Toxicities of Immune Checkpoint Inhibitors: A Multi-Center Retrospective Analysis. The American Journal Of Gastroenterology 2020, 115: s68-s68. DOI: 10.14309/01.ajg.0000702964.18533.22.
- Block P, Cao C, Robbins J, DiMarino A, Moleski S. S1295 Effects of Income and Resource Insecurity on the Clinical Course of Celiac Disease During the COVID-19 Pandemic. The American Journal Of Gastroenterology 2020, 115: s651-s652. DOI: 10.14309/01.ajg.0000707228.74151.fa.
- Block P, Shinn B, Roth C, Needleman L, Rosato E, Hann H. Vagaries of the Host Response in the Development of Hepatitis B-related Hepatocellular Carcinoma: A Case Series. Current Cancer Therapy Reviews 2020, 16: 253-258. DOI: 10.2174/1573394716666200129121051.
- Shieh C, Chalikonda D, Block P, Shinn B, Kistler C. Gastrointestinal toxicities of immune checkpoint inhibitors: a multicenter retrospective analysis. Annals Of Gastroenterology 2020, 34: 46-52. PMID: 33414621, PMCID: PMC7774670, DOI: 10.20524/aog.2020.0552.
- Cao C, Block P, Russell M, Parikh D, Robbins J, Kumar P, David A, DiMarino A, Moleski S. 1170 The Socioeconomic Impact on Presentation and Clinical Course of Celiac Disease. The American Journal Of Gastroenterology 2019, 114: s653-s654. DOI: 10.14309/01.ajg.0000594208.87456.df.
- Cao C, Block P, Russell M, Parikh D, Robbins J, Kumar P, David A, DiMarino A, Moleski S. 1176 A Sex-Based Comparison of Initial Presentation and Disease Severity of Celiac Disease. The American Journal Of Gastroenterology 2019, 114: s658-s658. DOI: 10.14309/01.ajg.0000594232.61907.0a.
- Amer K, Block P, Hong J, Tofani C. 2359 Acute Liver Failure in the Setting of HSV-Induced Hemophagocytic Lymphohistiocytosis. The American Journal Of Gastroenterology 2019, 114: s1313-s1313. DOI: 10.14309/01.ajg.0000598968.97660.72.
- Block P, Shinn B, Roth C, Baliff J, Zinner R, Hann H. Correction: Three primary malignancies in 17 years in a man with chronic hepatitis B. Hepatoma Research 2019, 5: null-null. DOI: 10.20517/2394-5079.2019.017.
- Block P, Shinn B, Roth C, Baliff J, Zinner R, Hann H. Three primary malignancies in 17 years in a man with chronic hepatitis B. Hepatoma Research 2019, 5: null-null. DOI: 10.20517/2394-5079.2019.17.
- Cheng X, Xia Y, Serti E, Block P, Chung M, Chayama K, Rehermann B, Liang T. Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages. Hepatology 2017, 66: 1779-1793. PMID: 28665004, PMCID: PMC5706781, DOI: 10.1002/hep.29348.
- Xia Y, Carpentier A, Cheng X, Block P, Zhao Y, Zhang Z, Protzer U, Liang T. Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions. Journal Of Hepatology 2016, 66: 494-503. PMID: 27746336, PMCID: PMC5316493, DOI: 10.1016/j.jhep.2016.10.009.
- Wang C, Hann H, Ye Z, Hann R, Wan S, Ye X, Block P, Li B, Myers R, Wang X, Juon H, Civan J, Chang M, Bae H, Xing J, Yang H. Prospective evidence of a circulating microRNA signature as a non-invasive marker of hepatocellular carcinoma in HBV patients. Oncotarget 2016, 5 DOI: 10.18632/oncotarget.9429.
- Muthumani K, Block P, Flingai S, Muruganantham N, Chaaithanya I, Sarangan G, Srikanth P, Vijayachari P, Sardesai N, Kim J, Ugen K, Weiner D. Synthetic DNA encoded antibody prophylaxis confers rapid protective immunity in vivo against Chikungunya virus infection. International Journal Of Infectious Diseases 2016, 45: 185. DOI: 10.1016/j.ijid.2016.02.432.
- Muthumani K, Block P, Flingai S, Muruganantham N, Chaaithanya I, Tingey C, Wise M, Reuschel E, Chung C, Muthumani A, Sarangan G, Srikanth P, Khan A, Vijayachari P, Sardesai N, Kim J, Ugen K, Weiner D. Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus. Journal Of Infectious Diseases 2016, 214: 369-378. PMID: 27001960, PMCID: PMC4936642, DOI: 10.1093/infdis/jiw111.
- Ternette N, Block P, Sánchez-Bernabéu Á, Borthwick N, Pappalardo E, Abdul-Jawad S, Ondondo B, Charles P, Dorrell L, Kessler B, Hanke T. Early Kinetics of the HLA Class I-Associated Peptidome of MVA.HIVconsv-Infected Cells. Journal Of Virology 2015, 89: 5760-5771. PMID: 25810538, PMCID: PMC4442425, DOI: 10.1128/jvi.03627-14.
- Sinnathamby G, Zerfass J, Hafner J, Block P, Nickens Z, Hobeika A, Secord A, Lyerly H, Morse M, Philip R. ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers. Clinical & Experimental Immunology 2010, 163: 324-332. PMID: 21175594, PMCID: PMC3048615, DOI: 10.1111/j.1365-2249.2010.04298.x.
Departments and Programs
Titles
- Assistant Professor of Medicine (Digestive Diseases)
Education & Training
- Transplant Hepatology FellowNYU Langone Health (2025)
- Gastroenterology & Hepatology FellowYale School of Medicine (2024)
- Resident PhysicianThomas Jefferson University Hospitals (2021)
- MDSidney Kimmel Medical College at Thomas Jefferson University, Medicine (2018)
- MScOxford University, Immunology (2013)
- BAHaverford College, Philosophy (2011)
Additional Information
Board Certifications
- AB of Internal Medicine, Gastroenterology (2024)
- AB of Internal Medicine, Internal Medicine (2021)
Professional Service
- AASLD Hepatitis B Special Interest Group (2025 - Present): Steering Committee member
- Hepatitis B Foundation Emerging Scholars Committee (2022 - Present): Steering Committee member
Publications
- Block SJ, Block PD, Graham CS, Sulkowski M, Wang S, Tu T, Cohen C. Sexual health and young people living with chronic hepatitis B: adopting a treatment as prevention framework. Lancet Gastroenterol Hepatol 2025, 10: 609-612. PMID: 40482651, DOI: 10.1016/S2468-1253(25)00123-2.
- Block P, Assis D. Hepatotoxicity of Chemotherapy and Immune Checkpoint Inhibitors. Clinics In Liver Disease 2025, 29: 483-501. PMID: 40670034, DOI: 10.1016/j.cld.2025.03.006.
- Block TM, Guo JT, Zoulim F, Rice CM, Thio CL, Schneider WM, Alter HJ, Jacobson IM, Gish RG, Block PD, Sulkowski M, Feld JJ, Cohen CA. New potent HBV replication inhibitors for the management of chronic hepatitis B are needed. Nat Rev Gastroenterol Hepatol 2025, 22: 150-151. PMID: 39910374, DOI: 10.1038/s41575-025-01037-z.
- Block P, Lim J. Unmet needs in the clinical management of chronic hepatitis B infection. Journal Of The Formosan Medical Association 2024, 124: 502-507. PMID: 39155176, DOI: 10.1016/j.jfma.2024.08.020.
- Block P, Strazzabosco M, Jaffe A. Approach to immunotherapy for HCC in the liver transplant population. Clinical Liver Disease 2024, 23: e0158. PMID: 38707244, PMCID: PMC11068135, DOI: 10.1097/cld.0000000000000158.
- Block PD, Farrell JJ, Li DK. A Rare Cause of Gastrointestinal Bleeding After Pancreaticoduodenectomy. Gastroenterology 2023, 165: 34-36. PMID: 36592728, DOI: 10.1053/j.gastro.2022.12.022.
- Lin S, Halegoua-DeMarzio D, Block P, Kao Y, Civan J, Shieh F, Song W, Hann H, Su Y. Persistently Elevated HBV Viral-Host Junction DNA in Urine as a Biomarker for Hepatocellular Carcinoma Minimum Residual Disease and Recurrence: A Pilot Study. Diagnostics 2023, 13: 1537. PMID: 37174929, PMCID: PMC10177231, DOI: 10.3390/diagnostics13091537.
- Block P, Lim J. Chronic Hepatitis B Virus: What an Internist Needs to Know Serologic Diagnosis, Treatment Options, and Hepatitis B Virus Reactivation. 2023, 107: 435-447. PMID: 37001946, DOI: 10.1016/j.mcna.2022.12.002.
- Halegoua-DeMarzio D, Hann H, Lin S, Block P, Park G, Civan J, Kao Y, Song W, Su Y. S2905 HBV-Host Junctional Sequences: A Novel Urine Tumor Marker for Recurrent Hepatitis B-Associated Hepatocellular Carcinoma With Low Alpha-Fetoprotein. The American Journal Of Gastroenterology 2022, 117: e1891-e1892. DOI: 10.14309/01.ajg.0000868260.09185.3f.
- Li CJ, Claxton BB, Block P, Reilly S, Manski S, Choudhary C. Acute Esophageal Necrosis Secondary to a Paraesophageal Hernia. Case Rep Gastroenterol 2021, 15: 594-597. PMID: 34616261, DOI: 10.1159/000517235.
- Block P, Shinn B, Kim J, Hann H. Hepatitis B-related hepatocellular carcinoma and stress: untangling the host immune response from clinical outcomes. Hepatic Oncology 2020, 8: hep35. PMID: 33680431, PMCID: PMC7907965, DOI: 10.2217/hep-2020-0028.
- Shieh C, Chalikonda D, Block P, Shinn B, Kistler C. S0178 Elevated Fecal Calprotectin: What Is on the Differential Diagnosis? The American Journal Of Gastroenterology 2020, 115: s68-s68. DOI: 10.14309/01.ajg.0000702760.56825.c6.
- Shieh C, Chalikonda D, Block P, Shinn B, Kistler C. S0229 Gastrointestinal Toxicities of Immune Checkpoint Inhibitors: A Multi-Center Retrospective Analysis. The American Journal Of Gastroenterology 2020, 115: s68-s68. DOI: 10.14309/01.ajg.0000702964.18533.22.
- Block P, Cao C, Robbins J, DiMarino A, Moleski S. S1295 Effects of Income and Resource Insecurity on the Clinical Course of Celiac Disease During the COVID-19 Pandemic. The American Journal Of Gastroenterology 2020, 115: s651-s652. DOI: 10.14309/01.ajg.0000707228.74151.fa.
- Block P, Shinn B, Roth C, Needleman L, Rosato E, Hann H. Vagaries of the Host Response in the Development of Hepatitis B-related Hepatocellular Carcinoma: A Case Series. Current Cancer Therapy Reviews 2020, 16: 253-258. DOI: 10.2174/1573394716666200129121051.
- Shieh C, Chalikonda D, Block P, Shinn B, Kistler C. Gastrointestinal toxicities of immune checkpoint inhibitors: a multicenter retrospective analysis. Annals Of Gastroenterology 2020, 34: 46-52. PMID: 33414621, PMCID: PMC7774670, DOI: 10.20524/aog.2020.0552.
- Cao C, Block P, Russell M, Parikh D, Robbins J, Kumar P, David A, DiMarino A, Moleski S. 1170 The Socioeconomic Impact on Presentation and Clinical Course of Celiac Disease. The American Journal Of Gastroenterology 2019, 114: s653-s654. DOI: 10.14309/01.ajg.0000594208.87456.df.
- Cao C, Block P, Russell M, Parikh D, Robbins J, Kumar P, David A, DiMarino A, Moleski S. 1176 A Sex-Based Comparison of Initial Presentation and Disease Severity of Celiac Disease. The American Journal Of Gastroenterology 2019, 114: s658-s658. DOI: 10.14309/01.ajg.0000594232.61907.0a.
- Amer K, Block P, Hong J, Tofani C. 2359 Acute Liver Failure in the Setting of HSV-Induced Hemophagocytic Lymphohistiocytosis. The American Journal Of Gastroenterology 2019, 114: s1313-s1313. DOI: 10.14309/01.ajg.0000598968.97660.72.
- Block P, Shinn B, Roth C, Baliff J, Zinner R, Hann H. Correction: Three primary malignancies in 17 years in a man with chronic hepatitis B. Hepatoma Research 2019, 5: null-null. DOI: 10.20517/2394-5079.2019.017.
- Block P, Shinn B, Roth C, Baliff J, Zinner R, Hann H. Three primary malignancies in 17 years in a man with chronic hepatitis B. Hepatoma Research 2019, 5: null-null. DOI: 10.20517/2394-5079.2019.17.
- Cheng X, Xia Y, Serti E, Block P, Chung M, Chayama K, Rehermann B, Liang T. Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages. Hepatology 2017, 66: 1779-1793. PMID: 28665004, PMCID: PMC5706781, DOI: 10.1002/hep.29348.
- Xia Y, Carpentier A, Cheng X, Block P, Zhao Y, Zhang Z, Protzer U, Liang T. Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions. Journal Of Hepatology 2016, 66: 494-503. PMID: 27746336, PMCID: PMC5316493, DOI: 10.1016/j.jhep.2016.10.009.
- Wang C, Hann H, Ye Z, Hann R, Wan S, Ye X, Block P, Li B, Myers R, Wang X, Juon H, Civan J, Chang M, Bae H, Xing J, Yang H. Prospective evidence of a circulating microRNA signature as a non-invasive marker of hepatocellular carcinoma in HBV patients. Oncotarget 2016, 5 DOI: 10.18632/oncotarget.9429.
- Muthumani K, Block P, Flingai S, Muruganantham N, Chaaithanya I, Sarangan G, Srikanth P, Vijayachari P, Sardesai N, Kim J, Ugen K, Weiner D. Synthetic DNA encoded antibody prophylaxis confers rapid protective immunity in vivo against Chikungunya virus infection. International Journal Of Infectious Diseases 2016, 45: 185. DOI: 10.1016/j.ijid.2016.02.432.
- Muthumani K, Block P, Flingai S, Muruganantham N, Chaaithanya I, Tingey C, Wise M, Reuschel E, Chung C, Muthumani A, Sarangan G, Srikanth P, Khan A, Vijayachari P, Sardesai N, Kim J, Ugen K, Weiner D. Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus. Journal Of Infectious Diseases 2016, 214: 369-378. PMID: 27001960, PMCID: PMC4936642, DOI: 10.1093/infdis/jiw111.
- Ternette N, Block P, Sánchez-Bernabéu Á, Borthwick N, Pappalardo E, Abdul-Jawad S, Ondondo B, Charles P, Dorrell L, Kessler B, Hanke T. Early Kinetics of the HLA Class I-Associated Peptidome of MVA.HIVconsv-Infected Cells. Journal Of Virology 2015, 89: 5760-5771. PMID: 25810538, PMCID: PMC4442425, DOI: 10.1128/jvi.03627-14.
- Sinnathamby G, Zerfass J, Hafner J, Block P, Nickens Z, Hobeika A, Secord A, Lyerly H, Morse M, Philip R. ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers. Clinical & Experimental Immunology 2010, 163: 324-332. PMID: 21175594, PMCID: PMC3048615, DOI: 10.1111/j.1365-2249.2010.04298.x.
Departments and Programs