Michelle Hughes, MD
Biography
Michelle Hughes, MD, is a gastroenterologist at Yale Medicine specializing in the practice of gastroenterology in the inpatient setting. She is dedicated to providing comprehensive and compassionate care of acute conditions involving the gastrointestinal system for patients admitted to the hospital. She is interested in quality improvement and clinical research on inpatient-focused and general GI issues. She works closely with trainees and is heavily involved in medical education at the student, resident, and fellow level.
Dr. Hughes earned her MD with honors from Albany Medical College. She completed her Internal Medicine residency at Boston Medical Center then went on to complete her Gastroenterology fellowship at the University of Rochester Medical Center in Rochester, NY.
She treats a variety of conditions including GI bleeding, inflammatory bowel diseases, evaluation and management of nutritional disorders, removal of foreign bodies, and diagnostic workup of malignancies of the GI tract. She performs the following procedures: esophagogastroduodenoscopy (a diagnostic endoscopic procedure for the upper digestive tract, also known as EGD), colonoscopy, feeding tube placement and removal, and video capsule endoscopy.
Titles
- Assistant Professor of Medicine (Digestive Diseases)
- Medical Chief of Quality and Safety, Digestive Health, Yale New Haven Health
Education & Training
- FellowUniversity of Rochester Medical Center (2019)
- ResidentBoston Medical Center (2016)
- InternBoston Medical Center (2014)
- MDAlbany Medical College (2013)
- BABoston College (2008)
Additional Information
- Kushlan Award: Yale School of Medicine (2021)
- Oral Presentation Category Award (General Endoscopy): American College of Gastroenterology (2020)
- Senior Talk Award: Boston Medical Center, Department of Internal Medicine (2016)
- Resident Quality Improvement Project Award: Boston Medical Center, Department of Internal Medicine (2015)
- Alpha Omega Alpha Honor Medical Society: (2013)
- American College of Gastroenterology Practice Management Summit (2023 - Present): Meeting Co-Chair
- American Society of Gastrointestinal Endoscopy GI Hospitalist SIG (2023 - Present): Chair
- Yale New Haven Health Digestive Health Care Signature Council (2023 - Present): Co-Chair
- American Society of Gastrointestinal Endoscopy GI Hospitalist SIG (2021 - 2023): Vice Chair
- American College of Gastroenterology (2020 - Present): ACG Practice Management Committee Member
- Householder S, Bham N, Lam R, Hughes M, Hung K, Sobani Z. Use of Blake Drains for Colonic Decompression in Acute Colonic Pseudo-Obstruction. IGIE 2025 DOI: 10.1016/j.igie.2025.11.005.
- Magier S, Stein D, Flanagan R, Jajoo K, Hughes M. S2989 Transforming the Gastroenterology Morbidity and Mortality Conference: A Multicenter, Fellow-Led Approach to Systems Thinking, Equity, and Safety Culture. The American Journal Of Gastroenterology 2025, 120: s642-s643. DOI: 10.14309/01.ajg.0001139416.14335.bf.
- Singh V, Chen G, Sena A, Rafter T, Xicola R, Sharbatji M, Liu J, Brown Q, Brierley K, Healy C, Hughes M, Kashyap N, Llor X. Cancer genetics evaluation among individuals at risk for Lynch syndrome across all qualifying indications. Journal Of Clinical Oncology 2025, 43: 10616-10616. DOI: 10.1200/jco.2025.43.16_suppl.10616.
- Singh V, Chen G, Sena A, Rafter T, Xicola R, Sharbatji M, Liu J, Brown Q, Brierley K, Healy C, Hughes M, Kashyap N, Llor X. At-risk cancer genetic syndrome identification (ARCAGEN-ID): Novel EHR integrated system to overcome disparities in identification and testing for cancer genetic syndromes. Journal Of Clinical Oncology 2025, 43: 1600-1600. DOI: 10.1200/jco.2025.43.16_suppl.1600.
- Gromisch C, Hung K, Ma S, Grimshaw A, Hughes M, Laine L, Sobani Z. Mo1265: A COMPARISON OF THALIDOMIDE AND SOMATOSTATIN ANALOGUES IN THE TREATMENT OF INTESTINAL ANGIOECTASIAS: A NETWORK META-ANALYSIS. Gastroenterology 2025, 169: s-1076-s-1077. DOI: 10.1016/s0016-5085(25)03378-5.
- Chen G, Senna A, Xicola R, Pugliese A, Hughes M, Liu J, Brown Q, Haight C, Kashyap N, Llor X. Tu1137: A NOVEL SYSTEMS APPROACH TO SCALE UP IDENTIFICATION AND TESTING OF INDIVIDUALS AT RISK FOR LYNCH SYNDROME WHILE MINIMIZING NEEDED RESOURCES: THE ARCAGEN-ID EXPERIENCE. Gastroenterology 2025, 169: s-1327. DOI: 10.1016/s0016-5085(25)03929-0.
- Xicola R, Singh V, Chen G, Senna A, Pugliese A, Hughes M, Rafter T, Liu J, Brown Q, Haight C, Kashyap N, Llor X. P577: Decreasing disparities in inherited cancer syndromes through a systems approach: The At-Risk Cancer Genetic Syndrome Identification (ARCAGEN-ID) system. Genetics In Medicine Open 2025, 3: 102425. DOI: 10.1016/j.gimo.2025.102425.
- Shung D, Li D, You K, Hung K, Laine L, Hughes M. Adoption of a gastroenterology hospitalist model and the impact on inpatient endoscopic practice volume: a controlled interrupted time-series analysis. IGIE 2024, 3: 329-332.e2. PMID: 41647077, PMCID: PMC12850757, DOI: 10.1016/j.igie.2024.04.008.
- Kats D, Chipkin B, Magier S, Li D, Hughes M, Ogurick A. S1735 Implementation of a Smart Text Post-Procedure Note Template Improves Communication of Inpatient Endoscopic Recommendations: A Quality Improvement Study. The American Journal Of Gastroenterology 2023, 118: s1293-s1294. DOI: 10.14309/01.ajg.0000956580.05834.d4.
- Wan D, Latorre M, Sun E, Hughes M, Buckholz A, Li D. A National Survey of the Infrastructure and Scope of Practice for Gastroenterology Hospitalists. Digestive Diseases And Sciences 2023, 68: 1148-1155. PMID: 36797510, DOI: 10.1007/s10620-023-07831-6.
- Li D, Ong S, Hughes M, Hung K, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2022, 57: 94-102. PMID: 36394111, DOI: 10.1111/apt.17278.
- Mezzacappa C, Hughes ML, Hung KW. An Uncommon Cause of Coffee Ground Emesis in a Young Woman With Remote Roux-en-Y Gastric Bypass. Gastroenterology 2022, 163: e16-e17. PMID: 35490784, DOI: 10.1053/j.gastro.2022.04.032.
- Chew M, Farrell J, Hughes M. Foreign Body Ingestion: A Colorful Dilemma. Gastro Hep Advances 2022, 1: 718-719. PMID: 39131853, PMCID: PMC11307417, DOI: 10.1016/j.gastha.2022.04.004.
- Ogurick AG, Magier SJ, Hughes ML. Quality Improvement During Gastroenterology Fellowship: The Experience of Improving Inpatient Post-endoscopy Communication. Digestive Diseases And Sciences 2022, 67: 1932-1936. PMID: 35239095, DOI: 10.1007/s10620-022-07436-5.
- Ilagan-Ying YC, Almeida MN, Kahler-Quesada A, Ying L, Hughes ML, Do A, Hung KW. Increased Mortality in Patients Undergoing Inpatient Endoscopy During the Early COVID-19 Pandemic. Digestive Diseases And Sciences 2022, 67: 5053-5062. PMID: 35182250, PMCID: PMC8857390, DOI: 10.1007/s10620-022-07414-x.
- Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology HospitalistsHughes ML, Li DK, Hung KW, Laine L. Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology Hospitalists. The American Journal Of Gastroenterology 2021, 117: 361-363. PMID: 34904965, DOI: 10.14309/ajg.0000000000001585.
- Hughes ML. Why I Like Being in with the Inpatient Crowd: How I Took the Non-traditional Path of the GI Hospitalist. Digestive Diseases And Sciences 2021, 66: 3674-3675. PMID: 34478026, DOI: 10.1007/s10620-021-07242-5.
- Cheong J, Hughes M, Bittner K, Walker C, Enslin S, Kaul V, Marino D. S3382 Hepatitis C Point of Care Testing as a Strategy to Increase Screening at the Time of Elective Outpatient Endoscopy. The American Journal Of Gastroenterology 2021, 116: s1392-s1392. DOI: 10.14309/01.ajg.0000787060.78829.eb.
- Ogurick A, Magier S, Hughes M. S1318 Implementation of an Electronic Medical Record Template Improves Communication of Post-Procedure Recommendations From Inpatient Gastroenterology Consultants. The American Journal Of Gastroenterology 2021, 116: s608-s608. DOI: 10.14309/01.ajg.0000778804.93205.79.
- Sun E, Hughes ML, Enslin S, Bull-Henry K, Kaul V, Littenberg GD. The Role of the Gastrointestinal Hospitalist in Optimizing Endoscopic Operations. Gastrointestinal Endoscopy Clinics Of North America 2021, 31: 681-693. PMID: 34538408, DOI: 10.1016/j.giec.2021.05.005.
- Hughes M, Sun E, Enslin S, Kaul V. The Role of the Gastroenterology Hospitalist in Modern Practice. Gastroenterology & Hepatology 2020, 16: 571-576. PMID: 34035692, PMCID: PMC8132627.
- Ilagan-Ying Y, Almeida M, Kahler-Quesada A, Ying L, Do A, Hughes M, Hung K. S0564 Understanding the Impact of the COVID-19 Pandemic on Inpatient Gastrointestinal Procedures: A Single Center Study. The American Journal Of Gastroenterology 2020, 115: s259-s259. DOI: 10.14309/01.ajg.0000704304.38893.a6.
- Hughes M, Cheong J, Enslin S, Kaul V, Kothari T, Kothari S. 1689 Managing Bouveret Syndrome in the Setting of Complex Foregut Anatomy: Impossible Is Nothing! The American Journal Of Gastroenterology 2019, 114: s942-s943. DOI: 10.14309/01.ajg.0000596288.35306.36.
- Hughes M, Walker C, Beyers L, Enslin S, Bittner K, Padula R, Kaul V, Marino D. Tu1645 – Killing Two Birds with One Stone: Using Hcv Point-Of-Care Testing At Time of Outpatient Endoscopy to Increase Screening Rates in the Baby Boomer Population. Gastroenterology 2019, 156: s-1074. DOI: 10.1016/s0016-5085(19)39649-0.
- Hughes M, Kukol W, Bittner K, Sprung B. Real World Utilization of a Mobile Application-Based Bowel Preparation on Quality Indicators in Colonoscopy. The American Journal Of Gastroenterology 2018, 113: s146. DOI: 10.14309/00000434-201810001-00253.
- Aranez JL, Miller J, Hughes M, DeCross A, Kaul V. A novel, duodenoscope-friendly endoscopic clip for treating massive upper-GI bleeding secondary to a Dieulafoy lesion. VideoGIE : An Official Video Journal Of The American Society For Gastrointestinal Endoscopy 2018, 3: 205-206. PMID: 30128389, PMCID: PMC6098687, DOI: 10.1016/j.vgie.2018.02.003.
- Thakkar S, Umar S, Hughes M, Kothari S, Kothari T, Enslin S, Kaul V. Should Atrophic Gastritis Be Considered a Relative Contraindication to Band-EMR in the Stomach? A Case Series. The American Journal Of Gastroenterology 2017, 112: s1153-s1154. DOI: 10.14309/00000434-201710001-02088.
- Hughes M, Qazi T, Berg A, Weinberg J, Chen X, Kelly CP, Farraye FA. Host Immune Response to Clostridium difficile Infection in Inflammatory Bowel Disease Patients. Inflammatory Bowel Diseases 2016, 22: 853-61. PMID: 26954708, PMCID: PMC4792680, DOI: 10.1097/MIB.0000000000000696.
Biography
Michelle Hughes, MD, is a gastroenterologist at Yale Medicine specializing in the practice of gastroenterology in the inpatient setting. She is dedicated to providing comprehensive and compassionate care of acute conditions involving the gastrointestinal system for patients admitted to the hospital. She is interested in quality improvement and clinical research on inpatient-focused and general GI issues. She works closely with trainees and is heavily involved in medical education at the student, resident, and fellow level.
Dr. Hughes earned her MD with honors from Albany Medical College. She completed her Internal Medicine residency at Boston Medical Center then went on to complete her Gastroenterology fellowship at the University of Rochester Medical Center in Rochester, NY.
She treats a variety of conditions including GI bleeding, inflammatory bowel diseases, evaluation and management of nutritional disorders, removal of foreign bodies, and diagnostic workup of malignancies of the GI tract. She performs the following procedures: esophagogastroduodenoscopy (a diagnostic endoscopic procedure for the upper digestive tract, also known as EGD), colonoscopy, feeding tube placement and removal, and video capsule endoscopy.
Titles
- Assistant Professor of Medicine (Digestive Diseases)
- Medical Chief of Quality and Safety, Digestive Health, Yale New Haven Health
Education & Training
- FellowUniversity of Rochester Medical Center (2019)
- ResidentBoston Medical Center (2016)
- InternBoston Medical Center (2014)
- MDAlbany Medical College (2013)
- BABoston College (2008)
Additional Information
- Kushlan Award: Yale School of Medicine (2021)
- Oral Presentation Category Award (General Endoscopy): American College of Gastroenterology (2020)
- Senior Talk Award: Boston Medical Center, Department of Internal Medicine (2016)
- Resident Quality Improvement Project Award: Boston Medical Center, Department of Internal Medicine (2015)
- Alpha Omega Alpha Honor Medical Society: (2013)
- American College of Gastroenterology Practice Management Summit (2023 - Present): Meeting Co-Chair
- American Society of Gastrointestinal Endoscopy GI Hospitalist SIG (2023 - Present): Chair
- Yale New Haven Health Digestive Health Care Signature Council (2023 - Present): Co-Chair
- American Society of Gastrointestinal Endoscopy GI Hospitalist SIG (2021 - 2023): Vice Chair
- American College of Gastroenterology (2020 - Present): ACG Practice Management Committee Member
- Householder S, Bham N, Lam R, Hughes M, Hung K, Sobani Z. Use of Blake Drains for Colonic Decompression in Acute Colonic Pseudo-Obstruction. IGIE 2025 DOI: 10.1016/j.igie.2025.11.005.
- Magier S, Stein D, Flanagan R, Jajoo K, Hughes M. S2989 Transforming the Gastroenterology Morbidity and Mortality Conference: A Multicenter, Fellow-Led Approach to Systems Thinking, Equity, and Safety Culture. The American Journal Of Gastroenterology 2025, 120: s642-s643. DOI: 10.14309/01.ajg.0001139416.14335.bf.
- Singh V, Chen G, Sena A, Rafter T, Xicola R, Sharbatji M, Liu J, Brown Q, Brierley K, Healy C, Hughes M, Kashyap N, Llor X. Cancer genetics evaluation among individuals at risk for Lynch syndrome across all qualifying indications. Journal Of Clinical Oncology 2025, 43: 10616-10616. DOI: 10.1200/jco.2025.43.16_suppl.10616.
- Singh V, Chen G, Sena A, Rafter T, Xicola R, Sharbatji M, Liu J, Brown Q, Brierley K, Healy C, Hughes M, Kashyap N, Llor X. At-risk cancer genetic syndrome identification (ARCAGEN-ID): Novel EHR integrated system to overcome disparities in identification and testing for cancer genetic syndromes. Journal Of Clinical Oncology 2025, 43: 1600-1600. DOI: 10.1200/jco.2025.43.16_suppl.1600.
- Gromisch C, Hung K, Ma S, Grimshaw A, Hughes M, Laine L, Sobani Z. Mo1265: A COMPARISON OF THALIDOMIDE AND SOMATOSTATIN ANALOGUES IN THE TREATMENT OF INTESTINAL ANGIOECTASIAS: A NETWORK META-ANALYSIS. Gastroenterology 2025, 169: s-1076-s-1077. DOI: 10.1016/s0016-5085(25)03378-5.
- Chen G, Senna A, Xicola R, Pugliese A, Hughes M, Liu J, Brown Q, Haight C, Kashyap N, Llor X. Tu1137: A NOVEL SYSTEMS APPROACH TO SCALE UP IDENTIFICATION AND TESTING OF INDIVIDUALS AT RISK FOR LYNCH SYNDROME WHILE MINIMIZING NEEDED RESOURCES: THE ARCAGEN-ID EXPERIENCE. Gastroenterology 2025, 169: s-1327. DOI: 10.1016/s0016-5085(25)03929-0.
- Xicola R, Singh V, Chen G, Senna A, Pugliese A, Hughes M, Rafter T, Liu J, Brown Q, Haight C, Kashyap N, Llor X. P577: Decreasing disparities in inherited cancer syndromes through a systems approach: The At-Risk Cancer Genetic Syndrome Identification (ARCAGEN-ID) system. Genetics In Medicine Open 2025, 3: 102425. DOI: 10.1016/j.gimo.2025.102425.
- Shung D, Li D, You K, Hung K, Laine L, Hughes M. Adoption of a gastroenterology hospitalist model and the impact on inpatient endoscopic practice volume: a controlled interrupted time-series analysis. IGIE 2024, 3: 329-332.e2. PMID: 41647077, PMCID: PMC12850757, DOI: 10.1016/j.igie.2024.04.008.
- Kats D, Chipkin B, Magier S, Li D, Hughes M, Ogurick A. S1735 Implementation of a Smart Text Post-Procedure Note Template Improves Communication of Inpatient Endoscopic Recommendations: A Quality Improvement Study. The American Journal Of Gastroenterology 2023, 118: s1293-s1294. DOI: 10.14309/01.ajg.0000956580.05834.d4.
- Wan D, Latorre M, Sun E, Hughes M, Buckholz A, Li D. A National Survey of the Infrastructure and Scope of Practice for Gastroenterology Hospitalists. Digestive Diseases And Sciences 2023, 68: 1148-1155. PMID: 36797510, DOI: 10.1007/s10620-023-07831-6.
- Li D, Ong S, Hughes M, Hung K, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2022, 57: 94-102. PMID: 36394111, DOI: 10.1111/apt.17278.
- Mezzacappa C, Hughes ML, Hung KW. An Uncommon Cause of Coffee Ground Emesis in a Young Woman With Remote Roux-en-Y Gastric Bypass. Gastroenterology 2022, 163: e16-e17. PMID: 35490784, DOI: 10.1053/j.gastro.2022.04.032.
- Chew M, Farrell J, Hughes M. Foreign Body Ingestion: A Colorful Dilemma. Gastro Hep Advances 2022, 1: 718-719. PMID: 39131853, PMCID: PMC11307417, DOI: 10.1016/j.gastha.2022.04.004.
- Ogurick AG, Magier SJ, Hughes ML. Quality Improvement During Gastroenterology Fellowship: The Experience of Improving Inpatient Post-endoscopy Communication. Digestive Diseases And Sciences 2022, 67: 1932-1936. PMID: 35239095, DOI: 10.1007/s10620-022-07436-5.
- Ilagan-Ying YC, Almeida MN, Kahler-Quesada A, Ying L, Hughes ML, Do A, Hung KW. Increased Mortality in Patients Undergoing Inpatient Endoscopy During the Early COVID-19 Pandemic. Digestive Diseases And Sciences 2022, 67: 5053-5062. PMID: 35182250, PMCID: PMC8857390, DOI: 10.1007/s10620-022-07414-x.
- Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology HospitalistsHughes ML, Li DK, Hung KW, Laine L. Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology Hospitalists. The American Journal Of Gastroenterology 2021, 117: 361-363. PMID: 34904965, DOI: 10.14309/ajg.0000000000001585.
- Hughes ML. Why I Like Being in with the Inpatient Crowd: How I Took the Non-traditional Path of the GI Hospitalist. Digestive Diseases And Sciences 2021, 66: 3674-3675. PMID: 34478026, DOI: 10.1007/s10620-021-07242-5.
- Cheong J, Hughes M, Bittner K, Walker C, Enslin S, Kaul V, Marino D. S3382 Hepatitis C Point of Care Testing as a Strategy to Increase Screening at the Time of Elective Outpatient Endoscopy. The American Journal Of Gastroenterology 2021, 116: s1392-s1392. DOI: 10.14309/01.ajg.0000787060.78829.eb.
- Ogurick A, Magier S, Hughes M. S1318 Implementation of an Electronic Medical Record Template Improves Communication of Post-Procedure Recommendations From Inpatient Gastroenterology Consultants. The American Journal Of Gastroenterology 2021, 116: s608-s608. DOI: 10.14309/01.ajg.0000778804.93205.79.
- Sun E, Hughes ML, Enslin S, Bull-Henry K, Kaul V, Littenberg GD. The Role of the Gastrointestinal Hospitalist in Optimizing Endoscopic Operations. Gastrointestinal Endoscopy Clinics Of North America 2021, 31: 681-693. PMID: 34538408, DOI: 10.1016/j.giec.2021.05.005.
- Hughes M, Sun E, Enslin S, Kaul V. The Role of the Gastroenterology Hospitalist in Modern Practice. Gastroenterology & Hepatology 2020, 16: 571-576. PMID: 34035692, PMCID: PMC8132627.
- Ilagan-Ying Y, Almeida M, Kahler-Quesada A, Ying L, Do A, Hughes M, Hung K. S0564 Understanding the Impact of the COVID-19 Pandemic on Inpatient Gastrointestinal Procedures: A Single Center Study. The American Journal Of Gastroenterology 2020, 115: s259-s259. DOI: 10.14309/01.ajg.0000704304.38893.a6.
- Hughes M, Cheong J, Enslin S, Kaul V, Kothari T, Kothari S. 1689 Managing Bouveret Syndrome in the Setting of Complex Foregut Anatomy: Impossible Is Nothing! The American Journal Of Gastroenterology 2019, 114: s942-s943. DOI: 10.14309/01.ajg.0000596288.35306.36.
- Hughes M, Walker C, Beyers L, Enslin S, Bittner K, Padula R, Kaul V, Marino D. Tu1645 – Killing Two Birds with One Stone: Using Hcv Point-Of-Care Testing At Time of Outpatient Endoscopy to Increase Screening Rates in the Baby Boomer Population. Gastroenterology 2019, 156: s-1074. DOI: 10.1016/s0016-5085(19)39649-0.
- Hughes M, Kukol W, Bittner K, Sprung B. Real World Utilization of a Mobile Application-Based Bowel Preparation on Quality Indicators in Colonoscopy. The American Journal Of Gastroenterology 2018, 113: s146. DOI: 10.14309/00000434-201810001-00253.
- Aranez JL, Miller J, Hughes M, DeCross A, Kaul V. A novel, duodenoscope-friendly endoscopic clip for treating massive upper-GI bleeding secondary to a Dieulafoy lesion. VideoGIE : An Official Video Journal Of The American Society For Gastrointestinal Endoscopy 2018, 3: 205-206. PMID: 30128389, PMCID: PMC6098687, DOI: 10.1016/j.vgie.2018.02.003.
- Thakkar S, Umar S, Hughes M, Kothari S, Kothari T, Enslin S, Kaul V. Should Atrophic Gastritis Be Considered a Relative Contraindication to Band-EMR in the Stomach? A Case Series. The American Journal Of Gastroenterology 2017, 112: s1153-s1154. DOI: 10.14309/00000434-201710001-02088.
- Hughes M, Qazi T, Berg A, Weinberg J, Chen X, Kelly CP, Farraye FA. Host Immune Response to Clostridium difficile Infection in Inflammatory Bowel Disease Patients. Inflammatory Bowel Diseases 2016, 22: 853-61. PMID: 26954708, PMCID: PMC4792680, DOI: 10.1097/MIB.0000000000000696.