Mehran M Sadeghi, MD
Cardiovascular Medicine
Titles
- Professor
Education & Training
- Cardiology, Nuclear Cardiology and Vascular Biology FellowYale University (2000)
- ResidentYale-New Haven Hospital (1995)
- MDNecker-Enfants Malades (1991)
Languages Spoken
- English
- Fārsī (Farsi)
- Français (French)
Additional Information
Honors & Recognitions
- Hermann Blumgart Award: Cardiovascular Council, Society of Nuclear Medicine and Molecular Imaging (2012)
Publications
- Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99:8301-5.
- Tatum JL, Narula J, Bender JR, Heller G, Sadeghi MM, Strauss HW: doi:10.1067.mnc.2003.391, Journal of Nuclear Cardiology, 2003; 10(2): 234-237
- Zhu Q, Piao D, Sadeghi MM, Sinusas AJ. Simultaneous optical coherence tomography imaging and beta particle detection. Optics Letters 2003, 28:1704-6.
- Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo.Sadeghi MM, Krassilnikova S, Zhang J, Gharaei AA, Fassaei HR, Esmailzadeh L, Kooshkabadi A, Edwards S, Yalamanchili P, Harris TD, Sinusas AJ, Zaret BL, Bender JR. Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo. Circulation 2004, 110:84-90.
- Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. The Journal Of Clinical Investigation 2004, 113:1684-91.
- Zeng L, Xu H, Chew TL, Chisholm R, Sadeghi MM, Kanwar YS, Danesh FR. Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27. Journal Of The American Society Of Nephrology : JASN 2004, 15:1711-20.
- Sadeghi MM, Schechner JS, Krassilnikova S, Gharaei AA, Zhang J, Kirkiles-Smith N, Sinusas AJ, Zaret BL, Bender JR. Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature. Transplantation Proceedings 2004, 36:1585-91.
- Piao D, Sadeghi MM, Zhang J, Chen Y, Sinusas AJ, Zhu Q. Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models. Journal Of Biomedical Optics 2005, 10:44010.
- Zhang J, Krassilnikova S, Gharaei AA, Fassaei HR, Esmailzadeh L, Asadi A, Edwards DS, Harris TD, Azure M, Tellides G, Sinusas AJ, Zaret BL, Bender JR, Sadeghi MM. Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2005, 19:1857-9.
- Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, Song J, Chow C, Jahanshad N, van Royen N, Buschmann I, Madri JA, Mendizabal M, Sinusas AJ. Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation 2005, 111:3255-60.
- Zeng L, Xu H, Chew TL, Eng E, Sadeghi MM, Adler S, Kanwar YS, Danesh FR. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2005, 19:1845-7.
- Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. American Journal Of Physiology. Renal Physiology 2006, 291:F995-1004.
- Sadeghi MM. The pathobiology of the vessel wall: implications for imaging. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2006, 13:402-14.
- Sadeghi MM, Bender JR. Activated alphavbeta3 integrin targeting in injury-induced vascular remodeling. Trends In Cardiovascular Medicine 2007, 17:5-10.
- Sadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al-Lamki RS, Takahashi T, Tellides G, Bender JR, Rodriguez ER. ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2007, 7:2098-105.
- Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ. Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. Journal Of Applied Physiology (Bethesda, Md. : 1985) 2008, 104:1504-12.
- Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM. Molecular imaging of activated matrix metalloproteinases in vascular remodeling. Circulation 2008, 118:1953-60.
- Imaging of Vascular Biology in the Heart Current Cardiovascular Imaging ReportsTavakoli S, Sadeghi MM, Imaging of Vascular Biology in the Heart Current Cardiovascular Imaging Reports, 2009, 2:40-49.
- Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM. Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination. The Journal Of Biological Chemistry 2009, 284:29376-82.
- Nahrendorf M, Sosnovik DE, French BA, Swirski FK, Bengel F, Sadeghi MM, Lindner JR, Wu JC, Kraitchman DL, Fayad ZA, Sinusas AJ. Multimodality cardiovascular molecular imaging, Part II. Circulation. Cardiovascular Imaging 2009, 2:56-70.
- Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. Journal Of Physiology And Pharmacology : An Official Journal Of The Polish Physiological Society 2009, 60 Suppl 4:117-23.
- Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL. Imaging atherosclerosis and vulnerable plaque. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2010, 51 Suppl 1:51S-65S.
- Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2010, 51:1107-15.
- Zhang J, Silva T, Yarovinsky T, Manes TD, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi MM. VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling. Circulation Research 2010, 107:408-17.
- Cardiovascular Council Board of Directors.. Cardiovascular nuclear imaging: balancing proven clinical value and potential radiation risk. J Nucl Med 2011, 52:1162-4.
- Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, Nie L, Sadeghi MM. Integrin-targeted imaging of inflammation in vascular remodeling. Arteriosclerosis, Thrombosis, And Vascular Biology 2011, 31:2820-6.
- Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM. Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2011, 52:1795-802.
- Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM. Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries. Arteriosclerosis, Thrombosis, And Vascular Biology 2011, 31:102-9.
- Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM. Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis. Arteriosclerosis, Thrombosis, And Vascular Biology 2012, 32:1849-55.
- Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, Klein B, Sadeghi MM, Chen J. Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology 2012, 119:765-70.
- Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM. Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. The Journal Of Clinical Investigation 2013, 123:5082-97.
- Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arteriosclerosis, Thrombosis, And Vascular Biology 2014, 34:2387-93.
- Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. Lipid lowering and imaging protease activation in atherosclerosis. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2014, 21:319-328.
- Golestani R, Sadeghi MM. Emergence of molecular imaging of aortic aneurysm: implications for risk stratification and management. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2014, 21:251-67; quiz 268-70.
- Tavakoli S, Vashist A, Sadeghi MM. Molecular imaging of plaque vulnerability. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2014, 21:1112-28; quiz 1129.
- Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM. Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2015, 56:933-8.
- Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Yun JJ, Sadeghi MM, Giordano FJ, Pober JS, Tellides G. Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients. Circulation Research 2015, 117:943-55.
- Sadeghi MM. (18)F-FDG PET and vascular inflammation: time to refine the paradigm? Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2015, 22:319-24.
- Golestani R, Razavian M, Nie L, Zhang J, Jung JJ, Ye Y, de Roo M, Hilgerink K, Liu C, Robinson SP, Sadeghi MM. Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm. Circulation. Cardiovascular Imaging 2015, 8.
- Sadeghi MM, Wu JC. Cardiovascular molecular imaging: Expanding the paradigms and parameters. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2015, 22:401-2.
- Toczek J, Sadeghi MM. A New Tracer for Imaging Atherosclerosis. Circulation. Cardiovascular Imaging 2016, 9.
- Toczek J, Meadows JL, Sadeghi MM. Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification. Circulation. Cardiovascular Imaging 2016, 9:e003023.
- Razavian M, Bordenave T, Georgiadis D, Beau F, Zhang J, Golestani R, Toczek J, Jung JJ, Ye Y, Kim HY, Han J, Dive V, Devel L, Sadeghi MM. Optical imaging of MMP-12 active form in inflammation and aneurysm. Scientific Reports 2016, 6:38345.
- Toczek J, Sadeghi MM. Molecular imaging concepts. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2016, 23:271-3.
- Bordenave T, Helle M, Beau F, Georgiadis D, Tepshi L, Bernes M, Ye Y, Levenez L, Poquet E, Nozach H, Razavian M, Toczek J, Stura EA, Dive V, Sadeghi MM, Devel L. Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes. Bioconjugate Chemistry 2016, 27:2407-2417.
- Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM. Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice. Scientific Reports 2016, 6:32659.
- Li X, Jung JJ, Nie L, Razavian M, Zhang J, Samuel V, Sadeghi MM. The neuropilin-like protein ESDN regulates insulin signaling and sensitivity. American Journal Of Physiology. Heart And Circulatory Physiology 2016, 310:H1184-93.
- Golestani R, Jung JJ, Sadeghi MM. Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology. Journal Of Clinical Medicine 2016, 5.
- Sadeghi MM. Molecular cardiovascular imaging is ready for prime time: almost there. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2016, 23:67-70.
- Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. Arteriosclerosis, Thrombosis, And Vascular Biology 2017, 37:328-340.
- Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM. Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58:138-143.
- Chareonthaitawee P, Beanlands RS, Chen W, Dorbala S, Miller EJ, Murthy VL, Birnie DH, Chen ES, Cooper LT, Tung RH, White ES, Borges-Neto S, Di Carli MF, Gropler RJ, Ruddy TD, Schindler TH, Blankstein R. Joint SNMMI-ASNC Expert Consensus Document on the Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58:1341-1353.
- Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation. Radiology 2017, 283:87-97.
- Toczek J, Ye Y, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Jung JJ, Sadeghi MM. Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58:1318-1323.
- Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R. Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis. Arteriosclerosis, Thrombosis, And Vascular Biology 2017, 37:1840-1848.
- Malm BJ, Sadeghi MM. Multi-modality molecular imaging of aortic aneurysms. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2017, 24:1239-1245.
- Iskandrian AE, Dilsizian V, Garcia EV, Beanlands RS, Cerqueira M, Soman P, Berman DS, Cuocolo A, Einstein AJ, Morgan CJ, Hage FG, Schelbert HR, Bax JJ, Wu JC, Shaw LJ, Sadeghi MM, Tamaki N, Kaufmann PA, Gropler R, Dorbala S, Van Decker W. Myocardial perfusion imaging: Lessons learned and work to be done-update. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2018, 25:39-52.
- Jung JJ, Jadbabaie F, Sadeghi MM. Molecular imaging of calcific aortic valve disease. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2018, 25:1148-1155.
- Ye Y, Toczek J, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Ghosh M, Jung JJ, Sadeghi MM. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Scientific Reports 2018, 8:11647.
- Sadeghi MM. 2018 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2018, 59:9N-15N.
- He BJ, Malm BJ, Carino M, Sadeghi MM. Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2019, 26:1688-1693.
- Tavakoli S, Sadeghi MM. 18F-Sodium Fluoride Positron Emission Tomography and Plaque Calcification. Circulation. Cardiovascular Imaging 2019, 12:e008712.
- Chen K, Miller EJ, Sadeghi MM. PET-Based Imaging of Ischemic Heart Disease. PET Clinics 2019, 14:211-221.
- Malm BJ, He BJ, Carino M, Sadeghi MM. Reply to letter to the editor regarding "prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population". Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2020, 27:1054.
- Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case-control study. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021, 28:688-694.
- Salarian M, Sadeghi MM. Hype or Hope18F-NaF Positron Emission Tomography for Vulnerable Coronary Plaque Imaging. Circulation. Cardiovascular Imaging 2019, 12:e009591.
- Toczek J, Bordenave T, Gona K, Kim HY, Beau F, Georgiadis D, Correia I, Yunpeng Y, Razavian M, Jung J, Lequin O, Dive V, Sadeghi MM, Devel L. Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging. Journal Of Medicinal Chemistry 2019, 62:9743-9752.
- Price NL, Miguel V, Ding W, Singh AK, Malik S, Rotllan N, Moshnikova A, Toczek J, Zeiss C, Sadeghi MM, Arias N, Baldán Á, Andreev OA, Rodríguez-Puyol D, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C, Lamas S. Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis. JCI Insight 2019, 4.
- Imaging Targets in Atherosclerosis.Smith, D., Sadeghi, MM, Bender, JR: Textbook of Cardiovascular Molecular Imaging. Informa Healthcare Publishing. Ed. Sinusas A, Gropler R, Glover D, Taegtmeyer H. 2007: Ch. 18, p. 189-202.
- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and ThrombosisJane-Wit D and Sadeghi MM: Molecular and Translational Vascular Medicine. Springer Science+Business Media New York. Ed. Homeister JW and Willis MS 2012: Ch. 5, 129-168.
- Applications of Molecular Small-Animal Imaging in CardiologyMarfatia R, Tavakoli S, Sadeghi MM: Multimodality Molecular Imaging of Small Animals. Springer Science+Business Media New York. Ed. Zaidi H. 2014: Ch. 20, 525-560.
- Chapter 9: Cardiovascular Molecular ImagingMorrison A, Wu JC, Sadeghi MM: Nuclear Cardiac Imaging: Principles and Applications, 5th Edition. Oxford University Press. New York, NY. Ed. Iskandrian A and Garcia E. 2015: Ch. 29, 601-36.
- Bender JR, Sadeghi MM, Watson C, Pfau S, Pardi R. Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91:3994-8.
- Sadeghi MM, Collinge M, Pardi R, Bender JR. Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165:2712-8.
- Sadeghi MM, Tiglio A, Sadigh K, O'Donnell L, Collinge M, Pardi R, Bender JR. Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors. Transplantation 2001, 71:1262-8.
- Sadeghi MM. 2019 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2019, 60:7N-13N.
- Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2020, 27:1578-1581.
- Pucar D, Sadeghi MM. 18F-Fluorodeoxyglucose PET imaging in aortic graft infection: many more questions than answers. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021, 28:1017-1020.
- Sadeghi MM. 2020 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2020, 61:15N-22N.
- Gona K, Toczek J, Ye Y, Sanzida N, Golbazi A, Boodagh P, Salarian M, Jung JJ, Rajendran S, Kukreja G, Wu TL, Devel L, Sadeghi MM. Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. Journal Of Medicinal Chemistry 2020, 63:15037-15049.
- Bellamkonda K, Nassiri N, Sadeghi MM, Zhang Y, Guzman RJ, Ochoa Chaar CI. Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database. Journal Of Vascular Surgery 2021, 74:729-737.
- Dorbala S, Zhou W, Sadeghi M. Advancing the mission of cardiovascular molecular imaging. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021.
- ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3.Coppo R, Orso F, Virga F, Dalmasso A, Baruffaldi D, Nie L, Clapero F, Dettori D, Quirico L, Grassi E, Defilippi P, Provero P, Valdembri D, Serini G, Sadeghi MM, Mazzone M, Taverna D. ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3. Cancer Letters 2021, 510:13-23.
- Toczek J, Boodagh P, Sanzida N, Ghim M, Salarian M, Gona K, Kukreja G, Rajendran S, Wei L, Han J, Zhang J, Jung JJ, Graham M, Liu X, Sadeghi MM. Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm. Theranostics 2021, 11:5876-5888.
Patient Care Organizations
Titles
- Professor
Education & Training
- Cardiology, Nuclear Cardiology and Vascular Biology FellowYale University (2000)
- ResidentYale-New Haven Hospital (1995)
- MDNecker-Enfants Malades (1991)
Languages Spoken
- English
- Fārsī (Farsi)
- Français (French)
Additional Information
Honors & Recognitions
- Hermann Blumgart Award: Cardiovascular Council, Society of Nuclear Medicine and Molecular Imaging (2012)
Publications
- Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99:8301-5.
- Tatum JL, Narula J, Bender JR, Heller G, Sadeghi MM, Strauss HW: doi:10.1067.mnc.2003.391, Journal of Nuclear Cardiology, 2003; 10(2): 234-237
- Zhu Q, Piao D, Sadeghi MM, Sinusas AJ. Simultaneous optical coherence tomography imaging and beta particle detection. Optics Letters 2003, 28:1704-6.
- Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo.Sadeghi MM, Krassilnikova S, Zhang J, Gharaei AA, Fassaei HR, Esmailzadeh L, Kooshkabadi A, Edwards S, Yalamanchili P, Harris TD, Sinusas AJ, Zaret BL, Bender JR. Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo. Circulation 2004, 110:84-90.
- Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. The Journal Of Clinical Investigation 2004, 113:1684-91.
- Zeng L, Xu H, Chew TL, Chisholm R, Sadeghi MM, Kanwar YS, Danesh FR. Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27. Journal Of The American Society Of Nephrology : JASN 2004, 15:1711-20.
- Sadeghi MM, Schechner JS, Krassilnikova S, Gharaei AA, Zhang J, Kirkiles-Smith N, Sinusas AJ, Zaret BL, Bender JR. Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature. Transplantation Proceedings 2004, 36:1585-91.
- Piao D, Sadeghi MM, Zhang J, Chen Y, Sinusas AJ, Zhu Q. Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models. Journal Of Biomedical Optics 2005, 10:44010.
- Zhang J, Krassilnikova S, Gharaei AA, Fassaei HR, Esmailzadeh L, Asadi A, Edwards DS, Harris TD, Azure M, Tellides G, Sinusas AJ, Zaret BL, Bender JR, Sadeghi MM. Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2005, 19:1857-9.
- Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, Song J, Chow C, Jahanshad N, van Royen N, Buschmann I, Madri JA, Mendizabal M, Sinusas AJ. Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation 2005, 111:3255-60.
- Zeng L, Xu H, Chew TL, Eng E, Sadeghi MM, Adler S, Kanwar YS, Danesh FR. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2005, 19:1845-7.
- Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. American Journal Of Physiology. Renal Physiology 2006, 291:F995-1004.
- Sadeghi MM. The pathobiology of the vessel wall: implications for imaging. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2006, 13:402-14.
- Sadeghi MM, Bender JR. Activated alphavbeta3 integrin targeting in injury-induced vascular remodeling. Trends In Cardiovascular Medicine 2007, 17:5-10.
- Sadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al-Lamki RS, Takahashi T, Tellides G, Bender JR, Rodriguez ER. ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2007, 7:2098-105.
- Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ. Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. Journal Of Applied Physiology (Bethesda, Md. : 1985) 2008, 104:1504-12.
- Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM. Molecular imaging of activated matrix metalloproteinases in vascular remodeling. Circulation 2008, 118:1953-60.
- Imaging of Vascular Biology in the Heart Current Cardiovascular Imaging ReportsTavakoli S, Sadeghi MM, Imaging of Vascular Biology in the Heart Current Cardiovascular Imaging Reports, 2009, 2:40-49.
- Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM. Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination. The Journal Of Biological Chemistry 2009, 284:29376-82.
- Nahrendorf M, Sosnovik DE, French BA, Swirski FK, Bengel F, Sadeghi MM, Lindner JR, Wu JC, Kraitchman DL, Fayad ZA, Sinusas AJ. Multimodality cardiovascular molecular imaging, Part II. Circulation. Cardiovascular Imaging 2009, 2:56-70.
- Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. Journal Of Physiology And Pharmacology : An Official Journal Of The Polish Physiological Society 2009, 60 Suppl 4:117-23.
- Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL. Imaging atherosclerosis and vulnerable plaque. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2010, 51 Suppl 1:51S-65S.
- Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2010, 51:1107-15.
- Zhang J, Silva T, Yarovinsky T, Manes TD, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi MM. VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling. Circulation Research 2010, 107:408-17.
- Cardiovascular Council Board of Directors.. Cardiovascular nuclear imaging: balancing proven clinical value and potential radiation risk. J Nucl Med 2011, 52:1162-4.
- Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, Nie L, Sadeghi MM. Integrin-targeted imaging of inflammation in vascular remodeling. Arteriosclerosis, Thrombosis, And Vascular Biology 2011, 31:2820-6.
- Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM. Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2011, 52:1795-802.
- Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM. Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries. Arteriosclerosis, Thrombosis, And Vascular Biology 2011, 31:102-9.
- Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM. Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis. Arteriosclerosis, Thrombosis, And Vascular Biology 2012, 32:1849-55.
- Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, Klein B, Sadeghi MM, Chen J. Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology 2012, 119:765-70.
- Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM. Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. The Journal Of Clinical Investigation 2013, 123:5082-97.
- Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arteriosclerosis, Thrombosis, And Vascular Biology 2014, 34:2387-93.
- Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. Lipid lowering and imaging protease activation in atherosclerosis. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2014, 21:319-328.
- Golestani R, Sadeghi MM. Emergence of molecular imaging of aortic aneurysm: implications for risk stratification and management. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2014, 21:251-67; quiz 268-70.
- Tavakoli S, Vashist A, Sadeghi MM. Molecular imaging of plaque vulnerability. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2014, 21:1112-28; quiz 1129.
- Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM. Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2015, 56:933-8.
- Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Yun JJ, Sadeghi MM, Giordano FJ, Pober JS, Tellides G. Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients. Circulation Research 2015, 117:943-55.
- Sadeghi MM. (18)F-FDG PET and vascular inflammation: time to refine the paradigm? Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2015, 22:319-24.
- Golestani R, Razavian M, Nie L, Zhang J, Jung JJ, Ye Y, de Roo M, Hilgerink K, Liu C, Robinson SP, Sadeghi MM. Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm. Circulation. Cardiovascular Imaging 2015, 8.
- Sadeghi MM, Wu JC. Cardiovascular molecular imaging: Expanding the paradigms and parameters. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2015, 22:401-2.
- Toczek J, Sadeghi MM. A New Tracer for Imaging Atherosclerosis. Circulation. Cardiovascular Imaging 2016, 9.
- Toczek J, Meadows JL, Sadeghi MM. Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification. Circulation. Cardiovascular Imaging 2016, 9:e003023.
- Razavian M, Bordenave T, Georgiadis D, Beau F, Zhang J, Golestani R, Toczek J, Jung JJ, Ye Y, Kim HY, Han J, Dive V, Devel L, Sadeghi MM. Optical imaging of MMP-12 active form in inflammation and aneurysm. Scientific Reports 2016, 6:38345.
- Toczek J, Sadeghi MM. Molecular imaging concepts. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2016, 23:271-3.
- Bordenave T, Helle M, Beau F, Georgiadis D, Tepshi L, Bernes M, Ye Y, Levenez L, Poquet E, Nozach H, Razavian M, Toczek J, Stura EA, Dive V, Sadeghi MM, Devel L. Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes. Bioconjugate Chemistry 2016, 27:2407-2417.
- Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM. Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice. Scientific Reports 2016, 6:32659.
- Li X, Jung JJ, Nie L, Razavian M, Zhang J, Samuel V, Sadeghi MM. The neuropilin-like protein ESDN regulates insulin signaling and sensitivity. American Journal Of Physiology. Heart And Circulatory Physiology 2016, 310:H1184-93.
- Golestani R, Jung JJ, Sadeghi MM. Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology. Journal Of Clinical Medicine 2016, 5.
- Sadeghi MM. Molecular cardiovascular imaging is ready for prime time: almost there. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2016, 23:67-70.
- Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. Arteriosclerosis, Thrombosis, And Vascular Biology 2017, 37:328-340.
- Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM. Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58:138-143.
- Chareonthaitawee P, Beanlands RS, Chen W, Dorbala S, Miller EJ, Murthy VL, Birnie DH, Chen ES, Cooper LT, Tung RH, White ES, Borges-Neto S, Di Carli MF, Gropler RJ, Ruddy TD, Schindler TH, Blankstein R. Joint SNMMI-ASNC Expert Consensus Document on the Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58:1341-1353.
- Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation. Radiology 2017, 283:87-97.
- Toczek J, Ye Y, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Jung JJ, Sadeghi MM. Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58:1318-1323.
- Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R. Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis. Arteriosclerosis, Thrombosis, And Vascular Biology 2017, 37:1840-1848.
- Malm BJ, Sadeghi MM. Multi-modality molecular imaging of aortic aneurysms. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2017, 24:1239-1245.
- Iskandrian AE, Dilsizian V, Garcia EV, Beanlands RS, Cerqueira M, Soman P, Berman DS, Cuocolo A, Einstein AJ, Morgan CJ, Hage FG, Schelbert HR, Bax JJ, Wu JC, Shaw LJ, Sadeghi MM, Tamaki N, Kaufmann PA, Gropler R, Dorbala S, Van Decker W. Myocardial perfusion imaging: Lessons learned and work to be done-update. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2018, 25:39-52.
- Jung JJ, Jadbabaie F, Sadeghi MM. Molecular imaging of calcific aortic valve disease. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2018, 25:1148-1155.
- Ye Y, Toczek J, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Ghosh M, Jung JJ, Sadeghi MM. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Scientific Reports 2018, 8:11647.
- Sadeghi MM. 2018 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2018, 59:9N-15N.
- He BJ, Malm BJ, Carino M, Sadeghi MM. Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2019, 26:1688-1693.
- Tavakoli S, Sadeghi MM. 18F-Sodium Fluoride Positron Emission Tomography and Plaque Calcification. Circulation. Cardiovascular Imaging 2019, 12:e008712.
- Chen K, Miller EJ, Sadeghi MM. PET-Based Imaging of Ischemic Heart Disease. PET Clinics 2019, 14:211-221.
- Malm BJ, He BJ, Carino M, Sadeghi MM. Reply to letter to the editor regarding "prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population". Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2020, 27:1054.
- Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case-control study. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021, 28:688-694.
- Salarian M, Sadeghi MM. Hype or Hope18F-NaF Positron Emission Tomography for Vulnerable Coronary Plaque Imaging. Circulation. Cardiovascular Imaging 2019, 12:e009591.
- Toczek J, Bordenave T, Gona K, Kim HY, Beau F, Georgiadis D, Correia I, Yunpeng Y, Razavian M, Jung J, Lequin O, Dive V, Sadeghi MM, Devel L. Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging. Journal Of Medicinal Chemistry 2019, 62:9743-9752.
- Price NL, Miguel V, Ding W, Singh AK, Malik S, Rotllan N, Moshnikova A, Toczek J, Zeiss C, Sadeghi MM, Arias N, Baldán Á, Andreev OA, Rodríguez-Puyol D, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C, Lamas S. Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis. JCI Insight 2019, 4.
- Imaging Targets in Atherosclerosis.Smith, D., Sadeghi, MM, Bender, JR: Textbook of Cardiovascular Molecular Imaging. Informa Healthcare Publishing. Ed. Sinusas A, Gropler R, Glover D, Taegtmeyer H. 2007: Ch. 18, p. 189-202.
- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and ThrombosisJane-Wit D and Sadeghi MM: Molecular and Translational Vascular Medicine. Springer Science+Business Media New York. Ed. Homeister JW and Willis MS 2012: Ch. 5, 129-168.
- Applications of Molecular Small-Animal Imaging in CardiologyMarfatia R, Tavakoli S, Sadeghi MM: Multimodality Molecular Imaging of Small Animals. Springer Science+Business Media New York. Ed. Zaidi H. 2014: Ch. 20, 525-560.
- Chapter 9: Cardiovascular Molecular ImagingMorrison A, Wu JC, Sadeghi MM: Nuclear Cardiac Imaging: Principles and Applications, 5th Edition. Oxford University Press. New York, NY. Ed. Iskandrian A and Garcia E. 2015: Ch. 29, 601-36.
- Bender JR, Sadeghi MM, Watson C, Pfau S, Pardi R. Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91:3994-8.
- Sadeghi MM, Collinge M, Pardi R, Bender JR. Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165:2712-8.
- Sadeghi MM, Tiglio A, Sadigh K, O'Donnell L, Collinge M, Pardi R, Bender JR. Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors. Transplantation 2001, 71:1262-8.
- Sadeghi MM. 2019 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2019, 60:7N-13N.
- Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2020, 27:1578-1581.
- Pucar D, Sadeghi MM. 18F-Fluorodeoxyglucose PET imaging in aortic graft infection: many more questions than answers. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021, 28:1017-1020.
- Sadeghi MM. 2020 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2020, 61:15N-22N.
- Gona K, Toczek J, Ye Y, Sanzida N, Golbazi A, Boodagh P, Salarian M, Jung JJ, Rajendran S, Kukreja G, Wu TL, Devel L, Sadeghi MM. Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. Journal Of Medicinal Chemistry 2020, 63:15037-15049.
- Bellamkonda K, Nassiri N, Sadeghi MM, Zhang Y, Guzman RJ, Ochoa Chaar CI. Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database. Journal Of Vascular Surgery 2021, 74:729-737.
- Dorbala S, Zhou W, Sadeghi M. Advancing the mission of cardiovascular molecular imaging. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021.
- ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3.Coppo R, Orso F, Virga F, Dalmasso A, Baruffaldi D, Nie L, Clapero F, Dettori D, Quirico L, Grassi E, Defilippi P, Provero P, Valdembri D, Serini G, Sadeghi MM, Mazzone M, Taverna D. ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3. Cancer Letters 2021, 510:13-23.
- Toczek J, Boodagh P, Sanzida N, Ghim M, Salarian M, Gona K, Kukreja G, Rajendran S, Wei L, Han J, Zhang J, Jung JJ, Graham M, Liu X, Sadeghi MM. Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm. Theranostics 2021, 11:5876-5888.
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