Maudry Laurent-Rolle, MD, PhD, BS
Titles
- Assistant Professor
Education & Training
- Research Fellow in Infectious DiseasesSection of Infectious Diseases (2020)
- FellowYale University (2019)
- ResidentAlbert Einstein/Montefiore Medical Center (2016)
- MDIcahn School of Medicine at Mount Sinai (2013)
- PhDIcahn School of Medicine at Mount Sinai, Microbiology (2011)
- Non Degree ProgramIcahn School of Medicine at Mount Sinai, Postbaccalaureate Research Education Program (2004)
- BSLong Island University, Biology (2001)
Languages Spoken
- English
Additional Information
Board Certifications
- AB of Internal Medicine, Infectious Disease (2018)
- AB of Internal Medicine, Internal Medicine (2016)
Professional Service
- Early Career Reviewer Program at the Center for Scientific Review (CSR), National Institutes of Health (2024): Early Career Reviewer Program at the Center for Scientific Review (CSR), National Institutes of Health.
- NEW HAVEN REGISTER (2023): “Yale researchers are working on a whole new type of vaccine, targeting the insects that carry pathogens”
- Medical Scientist Training Program Selection Committee, Yale School of Medicine (2022 - Present): Program Committee
- Department of Microbial Pathogenesis Graduate School Selection Committee (2022 - Present): Program Committee
- Department of Microbial Pathogenesis, Molecular Biology of Animal Viruses, Yale School of Medicine and Yale University (2022 - Present): Department of Microbial Pathogenesis, Molecular Biology of Animal Viruses, Yale School of Medicine and Yale University, New Haven, CT
- American College of Physicians (2022 - Present): Member
- Department of Medicine, Retention Working Group (2021 - 2024): Member
- Special Section, Current Research in Virological Science (CRVIRO) (2021): Guest Editor
- New York Times (2021): “How the ‘Alpha’ Coronavirus Variant Became So Powerful”
- Science Magazine (2021): “How a genetic twist in an ‘old’ variant may be driving Omicron and Delta today”
Publications
- Laurent-Rolle M, Morrison J. Type I Interferon-Induced Modification of Yellow Fever Virus NS5 Enhances Binding to Human STAT2. Methods In Molecular Biology 2025, 2913: 73-78. PMID: 40249426, DOI: 10.1007/978-1-0716-4458-4_7.
- Interferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral InfectionsHuang C, Laurent-Rolle M, Grove T, Hsu J. Interferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral Infections. Viruses 2025, 17: 132. PMID: 39861921, PMCID: PMC11768885, DOI: 10.3390/v17010132.
- Boytz R, Laurent-Rolle M. Balancing acts: The posttranslational modification tightrope of flavivirus replication. PLOS Pathogens 2024, 20: e1012626. PMID: 39466723, PMCID: PMC11516179, DOI: 10.1371/journal.ppat.1012626.
- Boytz R, Keita K, Pawlak J, Laurent-Rolle M. Flaviviruses manipulate mitochondrial processes to evade the innate immune response. Npj Viruses 2024, 2: 47. PMID: 39371935, PMCID: PMC11452341, DOI: 10.1038/s44298-024-00057-x.
- Boytz R, Keita K, Pawlak J, Laurent-Rolle M. Comprehensive Assessment of Inactivation Methods for Madariaga Virus. Viruses 2024, 16: 206. PMID: 38399982, PMCID: PMC10892135, DOI: 10.3390/v16020206.
- Pawlak J, Hsu J, Xia H, Han P, Suh H, Grove T, Morrison J, Shi P, Cresswell P, Laurent-Rolle M. CMPK2 restricts Zika virus replication by inhibiting viral translation. PLOS Pathogens 2023, 19: e1011286. PMID: 37075076, PMCID: PMC10150978, DOI: 10.1371/journal.ppat.1011286.
- Arshad N, Laurent-Rolle M, Ahmed W, Hsu J, Mitchell S, Pawlak J, Sengupta D, Biswas K, Cresswell P. SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2208525120. PMID: 36574644, PMCID: PMC9910621, DOI: 10.1073/pnas.2208525120.
- Hsu JC, Pawlak JB, Laurent-Rolle M, Cresswell P. Protocol for assessing translational regulation in mammalian cell lines by OP-Puro labeling. STAR Protocols 2022, 3: 101654. PMID: 36072758, PMCID: PMC9442383, DOI: 10.1016/j.xpro.2022.101654.
- Hsu JC, Laurent-Rolle M, Pawlak JB, Xia H, Kunte A, Hee JS, Lim J, Harris LD, Wood JM, Evans GB, Shi PY, Grove TL, Almo SC, Cresswell P. Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication. Molecular Cell 2022, 82: 1631-1642.e6. PMID: 35316659, PMCID: PMC9081181, DOI: 10.1016/j.molcel.2022.02.031.
- Briggs N, Gormally MV, Li F, Browning SL, Treggiari MM, Morrison A, Laurent-Rolle M, Deng Y, Hendrickson JE, Tormey CA, Desruisseaux MS. Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19. PLOS ONE 2021, 16: e0254453. PMID: 34320004, PMCID: PMC8318280, DOI: 10.1371/journal.pone.0254453.
- Hsu JC, Laurent-Rolle M, Pawlak JB, Wilen CB, Cresswell P. Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2101161118. PMID: 34045361, PMCID: PMC8214666, DOI: 10.1073/pnas.2101161118.
- Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, Son J, Kaczmarek ME, Zhang Z, Yeung ST, McCune BT, Chen RE, Tang F, Ren X, Chen X, Hsu JCC, Teplova M, Huang B, Deng H, Long Z, Mudianto T, Jin S, Lin P, Du J, Zang R, Su TT, Herrera A, Zhou M, Yan R, Cui J, Zhu J, Zhou Q, Wang T, Ma J, Koralov SB, Zhang Z, Aifantis I, Segal LN, Diamond MS, Khanna KM, Stapleford KA, Cresswell P, Liu Y, Ding S, Xie Q, Wang J. SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Immunity 2021, 54: 1304-1319.e9. PMID: 34048708, PMCID: PMC8106883, DOI: 10.1016/j.immuni.2021.05.006.
- Koff A, Laurent-Rolle M, Hsu JC, Malinis M. Prolonged incubation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a patient on rituximab therapy. Infection Control And Hospital Epidemiology 2020, 42: 1286-1288. PMID: 33023685, PMCID: PMC7578652, DOI: 10.1017/ice.2020.1239.
- Laurent-Rolle M, Morrison J. The Role of NS5 Protein in Determination of Host Cell Range for Yellow Fever Virus. DNA And Cell Biology 2019, 38: 1414-1417. PMID: 31633391, DOI: 10.1089/dna.2019.5115.
- Miorin L, Laurent-Rolle M, Pisanelli G, Co PH, Albrecht RA, García-Sastre A, Morrison J. Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism. Journal Of Virology 2019, 93: 10.1128/jvi.00151-19. PMID: 31043530, PMCID: PMC6600188, DOI: 10.1128/jvi.00151-19.
- Pisanelli G, Laurent-Rolle M, Manicassamy B, Belicha-Villanueva A, Morrison J, Lozano-Dubernard B, Castro-Peralta F, Iovane G, García-Sastre. A. La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocation. Virus Research 2015, 213: 11-22. PMID: 26546155, PMCID: PMC5538256, DOI: 10.1016/j.virusres.2015.10.027.
- Laurent-Rolle M, Morrison J, Rajsbaum R, Macleod JML, Pisanelli G, Pham A, Ayllon J, Miorin L, Martínez-Romero C, tenOever BR, García-Sastre A. The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon. Cell Host & Microbe 2014, 16: 314-327. PMID: 25211074, PMCID: PMC4176702, DOI: 10.1016/j.chom.2014.07.015.
- Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Martínez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, García-Sastre A. Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response. Immunity 2014, 40: 880-895. PMID: 24882218, PMCID: PMC4114019, DOI: 10.1016/j.immuni.2014.04.018.
- Morrison J, Laurent-Rolle M, Maestre AM, Rajsbaum R, Pisanelli G, Simon V, Mulder LC, Fernandez-Sesma A, García-Sastre A. Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling. PLOS Pathogens 2013, 9: e1003265. PMID: 23555265, PMCID: PMC3610674, DOI: 10.1371/journal.ppat.1003265.
- Innate Immunity and Flavivirus Infection. Molecular Virology and Control of FlavivirusesCaister Academic Press. Chapter 7
- Laurent-Rolle M, Boer EF, Lubick KJ, Wolfinbarger JB, Carmody AB, Rockx B, Liu W, Ashour J, Shupert WL, Holbrook MR, Barrett AD, Mason PW, Bloom ME, García-Sastre A, Khromykh AA, Best SM. The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling. Journal Of Virology 2010, 84: 3503-3515. PMID: 20106931, PMCID: PMC2838099, DOI: 10.1128/jvi.01161-09.
- Ashour J, Laurent-Rolle M, Plumlee C, Bernal D, Fernandez-Sesma A, Schindler C, García-Sastre A. Mouse STAT2 is a dengue virus host restriction factor. Cytokine 2009, 48: 62-63. DOI: 10.1016/j.cyto.2009.07.198.
- Ashour J, Laurent-Rolle M, Shi PY, García-Sastre A. NS5 of Dengue Virus Mediates STAT2 Binding and Degradation. Journal Of Virology 2009, 83: 5408-5418. PMID: 19279106, PMCID: PMC2681973, DOI: 10.1128/jvi.02188-08.
- Muñoz-Jordán JL, Laurent-Rolle M, Ashour J, Martínez-Sobrido L, Ashok M, Lipkin WI, García-Sastre A. Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses. Journal Of Virology 2005, 79: 8004-8013. PMID: 15956546, PMCID: PMC1143737, DOI: 10.1128/jvi.79.13.8004-8013.2005.
- Muñoz-Jordán J, Sánchez-Burgos GG, Laurent-Rolle M, García-Sastre A. Inhibition of interferon signaling by dengue virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14333-14338. PMID: 14612562, PMCID: PMC283592, DOI: 10.1073/pnas.2335168100.
Departments and Programs
Titles
- Assistant Professor
Education & Training
- Research Fellow in Infectious DiseasesSection of Infectious Diseases (2020)
- FellowYale University (2019)
- ResidentAlbert Einstein/Montefiore Medical Center (2016)
- MDIcahn School of Medicine at Mount Sinai (2013)
- PhDIcahn School of Medicine at Mount Sinai, Microbiology (2011)
- Non Degree ProgramIcahn School of Medicine at Mount Sinai, Postbaccalaureate Research Education Program (2004)
- BSLong Island University, Biology (2001)
Languages Spoken
- English
Additional Information
Board Certifications
- AB of Internal Medicine, Infectious Disease (2018)
- AB of Internal Medicine, Internal Medicine (2016)
Professional Service
- Early Career Reviewer Program at the Center for Scientific Review (CSR), National Institutes of Health (2024): Early Career Reviewer Program at the Center for Scientific Review (CSR), National Institutes of Health.
- NEW HAVEN REGISTER (2023): “Yale researchers are working on a whole new type of vaccine, targeting the insects that carry pathogens”
- Medical Scientist Training Program Selection Committee, Yale School of Medicine (2022 - Present): Program Committee
- Department of Microbial Pathogenesis Graduate School Selection Committee (2022 - Present): Program Committee
- Department of Microbial Pathogenesis, Molecular Biology of Animal Viruses, Yale School of Medicine and Yale University (2022 - Present): Department of Microbial Pathogenesis, Molecular Biology of Animal Viruses, Yale School of Medicine and Yale University, New Haven, CT
- American College of Physicians (2022 - Present): Member
- Department of Medicine, Retention Working Group (2021 - 2024): Member
- Special Section, Current Research in Virological Science (CRVIRO) (2021): Guest Editor
- New York Times (2021): “How the ‘Alpha’ Coronavirus Variant Became So Powerful”
- Science Magazine (2021): “How a genetic twist in an ‘old’ variant may be driving Omicron and Delta today”
Publications
- Laurent-Rolle M, Morrison J. Type I Interferon-Induced Modification of Yellow Fever Virus NS5 Enhances Binding to Human STAT2. Methods In Molecular Biology 2025, 2913: 73-78. PMID: 40249426, DOI: 10.1007/978-1-0716-4458-4_7.
- Interferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral InfectionsHuang C, Laurent-Rolle M, Grove T, Hsu J. Interferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral Infections. Viruses 2025, 17: 132. PMID: 39861921, PMCID: PMC11768885, DOI: 10.3390/v17010132.
- Boytz R, Laurent-Rolle M. Balancing acts: The posttranslational modification tightrope of flavivirus replication. PLOS Pathogens 2024, 20: e1012626. PMID: 39466723, PMCID: PMC11516179, DOI: 10.1371/journal.ppat.1012626.
- Boytz R, Keita K, Pawlak J, Laurent-Rolle M. Flaviviruses manipulate mitochondrial processes to evade the innate immune response. Npj Viruses 2024, 2: 47. PMID: 39371935, PMCID: PMC11452341, DOI: 10.1038/s44298-024-00057-x.
- Boytz R, Keita K, Pawlak J, Laurent-Rolle M. Comprehensive Assessment of Inactivation Methods for Madariaga Virus. Viruses 2024, 16: 206. PMID: 38399982, PMCID: PMC10892135, DOI: 10.3390/v16020206.
- Pawlak J, Hsu J, Xia H, Han P, Suh H, Grove T, Morrison J, Shi P, Cresswell P, Laurent-Rolle M. CMPK2 restricts Zika virus replication by inhibiting viral translation. PLOS Pathogens 2023, 19: e1011286. PMID: 37075076, PMCID: PMC10150978, DOI: 10.1371/journal.ppat.1011286.
- Arshad N, Laurent-Rolle M, Ahmed W, Hsu J, Mitchell S, Pawlak J, Sengupta D, Biswas K, Cresswell P. SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2208525120. PMID: 36574644, PMCID: PMC9910621, DOI: 10.1073/pnas.2208525120.
- Hsu JC, Pawlak JB, Laurent-Rolle M, Cresswell P. Protocol for assessing translational regulation in mammalian cell lines by OP-Puro labeling. STAR Protocols 2022, 3: 101654. PMID: 36072758, PMCID: PMC9442383, DOI: 10.1016/j.xpro.2022.101654.
- Hsu JC, Laurent-Rolle M, Pawlak JB, Xia H, Kunte A, Hee JS, Lim J, Harris LD, Wood JM, Evans GB, Shi PY, Grove TL, Almo SC, Cresswell P. Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication. Molecular Cell 2022, 82: 1631-1642.e6. PMID: 35316659, PMCID: PMC9081181, DOI: 10.1016/j.molcel.2022.02.031.
- Briggs N, Gormally MV, Li F, Browning SL, Treggiari MM, Morrison A, Laurent-Rolle M, Deng Y, Hendrickson JE, Tormey CA, Desruisseaux MS. Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19. PLOS ONE 2021, 16: e0254453. PMID: 34320004, PMCID: PMC8318280, DOI: 10.1371/journal.pone.0254453.
- Hsu JC, Laurent-Rolle M, Pawlak JB, Wilen CB, Cresswell P. Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2101161118. PMID: 34045361, PMCID: PMC8214666, DOI: 10.1073/pnas.2101161118.
- Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, Son J, Kaczmarek ME, Zhang Z, Yeung ST, McCune BT, Chen RE, Tang F, Ren X, Chen X, Hsu JCC, Teplova M, Huang B, Deng H, Long Z, Mudianto T, Jin S, Lin P, Du J, Zang R, Su TT, Herrera A, Zhou M, Yan R, Cui J, Zhu J, Zhou Q, Wang T, Ma J, Koralov SB, Zhang Z, Aifantis I, Segal LN, Diamond MS, Khanna KM, Stapleford KA, Cresswell P, Liu Y, Ding S, Xie Q, Wang J. SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Immunity 2021, 54: 1304-1319.e9. PMID: 34048708, PMCID: PMC8106883, DOI: 10.1016/j.immuni.2021.05.006.
- Koff A, Laurent-Rolle M, Hsu JC, Malinis M. Prolonged incubation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a patient on rituximab therapy. Infection Control And Hospital Epidemiology 2020, 42: 1286-1288. PMID: 33023685, PMCID: PMC7578652, DOI: 10.1017/ice.2020.1239.
- Laurent-Rolle M, Morrison J. The Role of NS5 Protein in Determination of Host Cell Range for Yellow Fever Virus. DNA And Cell Biology 2019, 38: 1414-1417. PMID: 31633391, DOI: 10.1089/dna.2019.5115.
- Miorin L, Laurent-Rolle M, Pisanelli G, Co PH, Albrecht RA, García-Sastre A, Morrison J. Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism. Journal Of Virology 2019, 93: 10.1128/jvi.00151-19. PMID: 31043530, PMCID: PMC6600188, DOI: 10.1128/jvi.00151-19.
- Pisanelli G, Laurent-Rolle M, Manicassamy B, Belicha-Villanueva A, Morrison J, Lozano-Dubernard B, Castro-Peralta F, Iovane G, García-Sastre. A. La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocation. Virus Research 2015, 213: 11-22. PMID: 26546155, PMCID: PMC5538256, DOI: 10.1016/j.virusres.2015.10.027.
- Laurent-Rolle M, Morrison J, Rajsbaum R, Macleod JML, Pisanelli G, Pham A, Ayllon J, Miorin L, Martínez-Romero C, tenOever BR, García-Sastre A. The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon. Cell Host & Microbe 2014, 16: 314-327. PMID: 25211074, PMCID: PMC4176702, DOI: 10.1016/j.chom.2014.07.015.
- Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Martínez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, García-Sastre A. Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response. Immunity 2014, 40: 880-895. PMID: 24882218, PMCID: PMC4114019, DOI: 10.1016/j.immuni.2014.04.018.
- Morrison J, Laurent-Rolle M, Maestre AM, Rajsbaum R, Pisanelli G, Simon V, Mulder LC, Fernandez-Sesma A, García-Sastre A. Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling. PLOS Pathogens 2013, 9: e1003265. PMID: 23555265, PMCID: PMC3610674, DOI: 10.1371/journal.ppat.1003265.
- Innate Immunity and Flavivirus Infection. Molecular Virology and Control of FlavivirusesCaister Academic Press. Chapter 7
- Laurent-Rolle M, Boer EF, Lubick KJ, Wolfinbarger JB, Carmody AB, Rockx B, Liu W, Ashour J, Shupert WL, Holbrook MR, Barrett AD, Mason PW, Bloom ME, García-Sastre A, Khromykh AA, Best SM. The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling. Journal Of Virology 2010, 84: 3503-3515. PMID: 20106931, PMCID: PMC2838099, DOI: 10.1128/jvi.01161-09.
- Ashour J, Laurent-Rolle M, Plumlee C, Bernal D, Fernandez-Sesma A, Schindler C, García-Sastre A. Mouse STAT2 is a dengue virus host restriction factor. Cytokine 2009, 48: 62-63. DOI: 10.1016/j.cyto.2009.07.198.
- Ashour J, Laurent-Rolle M, Shi PY, García-Sastre A. NS5 of Dengue Virus Mediates STAT2 Binding and Degradation. Journal Of Virology 2009, 83: 5408-5418. PMID: 19279106, PMCID: PMC2681973, DOI: 10.1128/jvi.02188-08.
- Muñoz-Jordán JL, Laurent-Rolle M, Ashour J, Martínez-Sobrido L, Ashok M, Lipkin WI, García-Sastre A. Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses. Journal Of Virology 2005, 79: 8004-8013. PMID: 15956546, PMCID: PMC1143737, DOI: 10.1128/jvi.79.13.8004-8013.2005.
- Muñoz-Jordán J, Sánchez-Burgos GG, Laurent-Rolle M, García-Sastre A. Inhibition of interferon signaling by dengue virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14333-14338. PMID: 14612562, PMCID: PMC283592, DOI: 10.1073/pnas.2335168100.
Departments and Programs