Loren Laine, MD
Biography
Loren Laine, MD, is a gastroenterologist who specializes in digestive diseases, including stomach ulcers and gastrointestinal bleeding.
As a professor of medicine at the Yale School of Medicine, Dr. Laine is committed to advancing understanding and treatment of digestive disorders. His research interests include gastrointestinal bleeding, ulcers, and fecal microbiota transplantation.
Dr. Laine completed his medical training at UCLA School of Medicine, followed by a residency in medicine at UCLA and a fellowship in gastroenterology at UCSD. He is a past President of the American Gastroenterological Association.
Titles
- Professor of Medicine (Digestive Diseases)
- Chief, Section of Digestive Diseases, Internal Medicine
- Medical Chief, Digestive Health, Yale New Haven Health
Education & Training
- FellowshipUCSD (1984)
- ResidencyUCLA (1982)
- MDUCLA School of Medicine (1979)
Additional Information
Honors & Recognitions
- Elliot Weser Lectureship: University of Texas, San Antonio (2021)
- Howard Spiro Teaching Award: (2020)
- Julius Friedenwald Medal, American Gastroenterological Association: (2018)
- Watson Lectureship: Royal College of Physicians and Surgeons, Glasgow (2017)
- Sunder J. Mehta Memorial Lectureship: University of Colorado (2017)
- Howard Spiro Teaching Award: (2014)
- Frederick and Irene Stare Visiting Professorship: Harvard Medical School, Tufts Medical School, Newton-Wellesley Hospital (2013)
- Barbara Frank Visiting Professorship: Drexel University School of Medicine (2013)
- Fellow: Royal College of Physicians (London) (2013)
- Ken and Louise Rosenberg Visiting Professorship: Harvard Medical School, Brigham & Women's Hospital (2013)
Board Certifications
- AB of Internal Medicine, Gastroenterology (1985)
- AB of Internal Medicine, Internal Medicine (1982)
Professional Service
- American Gastroenterological Association (2021 - Present): Advisor
- Digestive Disease Week (2020 - 2026): Chair
- Journal of Clinical Gastroenterology (2014 - 2017): Editorial Board Member
- American Gastroenterological Association (2013 - 2014): Chair
- American Gastroenterological Association (2012 - 2013): President
- American Gastroenterological Association Council (2003 - 2006): Chair
- Clinical Gastroenterlogy and Hepatology (AGA) (2003 - 2006): Editorial Board Member
- Gastroenterology (AGA) (2002 - 2006): Associate Editor
- Evidence-Based Gastroenterology (2000 - 2009): Editorial Board Member
- American Journal of Gastroenterology (ACG) (1997 - 2004): Editorial Board Member
Publications
- Giuffrè M, You K, Pang Z, Kresevic S, Chung S, Chen R, Ko Y, Chan C, Saarinen T, Ajcevic M, Crocè L, Garcia-Tsao G, Gralnek I, Sung J, Barkun A, Laine L, Sekhon J, Stadie B, Shung D. Expert of Experts Verification and Alignment (EVAL) Framework for Large Language Models Safety in Gastroenterology. Npj Digital Medicine 2025, 8: 242. PMID: 40319106, PMCID: PMC12049514, DOI: 10.1038/s41746-025-01589-z.
- Samnani S, Forbes N, Barkun A, Laine L, Leontiadis G, Alali A, Armstrong D, Borgaonkar M, Carman N, Carroll M, Gralnek I, Hookey L, Ibrahim M, Lau J, Pittayanon R, Sey M, Haidry R, Yuan Y, Tse F. WHICH IS THE BEST ENDOSCOPIC HEMOSTATIC THERAPY FOR DIEULAFOY’S LESIONS? A SYSTEMATIC REVIEW AND META-ANALYSIS. Gastrointestinal Endoscopy 2025, 101: s674. DOI: 10.1016/j.gie.2025.03.1160.
- Minhas G, Bukhari A, Forbes N, Barkun A, Laine L, Leontiadis G, Alali A, Armstrong D, Borgaonkar M, Carman N, Carroll M, Gralnek I, Hookey L, Ibrahim M, Lau J, Pittayanon R, Sey M, Tse F. TOPICAL HEMOSTATIC AGENTS: A POTENTIAL BREAKTHROUGH IN MALIGNANCY-RELATED GI BLEEDING? A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. Gastrointestinal Endoscopy 2025, 101: s669-s670. DOI: 10.1016/j.gie.2025.03.1152.
- Spechler S, Kolb J, Dunbar K, Gyawali C, Bell R, Fass R, Katz P, Laine L, Lipham J, Schnoll-Sussman F, Souza R, Yadlapati R, Kahrilas P. American Foregut Society White Paper Report on the Use of Potassium-Competitive Acid Blockers in the Treatment of Gastroesophageal Reflux Disease. Foregut The Journal Of The American Foregut Society 2025 DOI: 10.1177/26345161251325874.
- Samnani S, Yuan Y, Leontiadis G, Barkun A, Laine L, Tse F. A96 WHICH IS THE BEST ENDOSCOPIC HEMOSTATIC THERAPY FOR DIEULAFOY’S LESIONS? A SYSTEMATIC REVIEW AND META-ANALYSIS. Journal Of The Canadian Association Of Gastroenterology 2025, 8: i37-i37. PMCID: PMC11807509, DOI: 10.1093/jcag/gwae059.096.
- Minhas G, Bukhari A, Yuan Y, Leontiadis G, Laine L, Barkun A, Tse F. A43 TOPICAL HEMOSTATIC AGENTS: A POTENTIAL BREAKTHROUGH IN MALIGNANCY-RELATED GI BLEEDING? A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. Journal Of The Canadian Association Of Gastroenterology 2025, 8: i17-i17. PMCID: PMC11807633, DOI: 10.1093/jcag/gwae059.043.
- Patel A, Laine L, Moayyedi P. Reply. Gastroenterology 2025, 168: 849-850. PMID: 39848603, DOI: 10.1053/j.gastro.2025.01.001.
- Chey W, Mégraud F, Laine L, Smith N, Leifke E, Hunt B, Howden C. Influence of patient characteristics on Helicobacter pylori eradication with Vonoprazan: A subgroup analysis of the pHalcon‐HP trial. JGH Open 2024, 8: e70044. PMID: 39554983, PMCID: PMC11567116, DOI: 10.1002/jgh3.70044.
- Antunes C, Ghosh G, Katz P, Yadlapati R, Leifke E, Harris T, Graham H, Laine L. S655 Vonoprazan Improves Nocturnal Gastroesophageal Reflux Symptoms in Non-Erosive Reflux Disease. The American Journal Of Gastroenterology 2024, 119: s452-s453. DOI: 10.14309/01.ajg.0001031988.74205.82.
- Zheng N, Keloth V, You K, Kats D, Li D, Deshpande O, Sachar H, Xu H, Laine L, Shung D. Detection of Gastrointestinal Bleeding With Large Language Models to Aid Quality Improvement and Appropriate Reimbursement. Gastroenterology 2024, 168: 111-120.e4. PMID: 39304088, DOI: 10.1053/j.gastro.2024.09.014.
- Patel A, Laine L, Moayyedi P, Wu J. AGA Clinical Practice Update on Integrating Potassium-Competitive Acid Blockers Into Clinical Practice: Expert Review. Gastroenterology 2024, 167: 1228-1238. PMID: 39269391, DOI: 10.1053/j.gastro.2024.06.038.
- Shung D, Chan C, You K, Nakamura S, Saarinen T, Zheng N, Simonov M, Li D, Tsay C, Kawamura Y, Shen M, Hsiao A, Sekhon J, Laine L. Validation of an Electronic Health Record–Based Machine Learning Model Compared With Clinical Risk Scores for Gastrointestinal Bleeding. Gastroenterology 2024, 167: 1198-1212. PMID: 38971198, PMCID: PMC11493512, DOI: 10.1053/j.gastro.2024.06.030.
- Shung D, Li D, You K, Hung K, Laine L, Hughes M. Adoption of a gastroenterology hospitalist model and the impact on inpatient endoscopic practice volume: a controlled interrupted time-series analysis. IGIE 2024, 3: 329-332.e2. DOI: 10.1016/j.igie.2024.04.008.
- Spechler S, Laine L, DeVault K, Nabulsi A, Hunt B, Katz P. Comparison of Los Angeles Grades of Erosive Esophagitis Scored by Local Investigators vs Central Adjudicators in a Clinical Trial. Clinical Gastroenterology And Hepatology 2024, 22: 2526-2528.e1. PMID: 38777170, DOI: 10.1016/j.cgh.2024.05.007.
- Laine L, Spechler S, Yadlapati R, Schnoll-Sussman F, Smith N, Leifke E, Harris T, Hunt B, Fass R, Katz P. Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial. Clinical Gastroenterology And Hepatology 2024, 22: 2211-2220.e10. PMID: 38750866, DOI: 10.1016/j.cgh.2024.05.004.
- Rajashekar N, Shin Y, Pu Y, Chung S, You K, Giuffre M, Chan C, Saarinen T, Hsiao A, Sekhon J, Wong A, Evans L, Kizilcec R, Laine L, Mccall T, Shung D. Human-Algorithmic Interaction Using a Large Language Model-Augmented Artificial Intelligence Clinical Decision Support System. 2024, 1-20. DOI: 10.1145/3613904.3642024.
- Rajashekar N, Chan C, Laine L, Shung D. Mo1066 LARGE LANGUAGE MODEL-BASED SIMULATED PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING FOR MEDICAL EDUCATION – A PILOT STUDY WITH EMPATHGPT. Gastroenterology 2024, 166: s-933. DOI: 10.1016/s0016-5085(24)02628-3.
- Giuffrè M, You K, Chung S, Kresevic S, Chan C, Saarinen T, Nakamura S, Laine L, Sung J, Garcia-Tsao G, Gralnek I, Barkun A, Sekhon J, Shung D. Su1979 GUTGPT: NOVEL LARGE LANGUAGE MODEL PIPELINE OUTPERFORMS OTHER LARGE LANGUAGE MODELS IN ACCURACY AND SIMILARITY TO INTERNATIONAL EXPERTS FOR GUIDELINE RECOMMENDED MANAGEMENT OF PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING. Gastroenterology 2024, 166: s-889-s-890. DOI: 10.1016/s0016-5085(24)02528-9.
- Chung S, Rajashekar N, Pu Y, Shin Y, Giuffrè M, Chan C, You K, Saarinen T, Hsiao A, Sekhon J, Wong A, Evans L, McCall T, Kizilcec R, Laine L, Shung D. 407 IMPACT OF ARTIFICIAL INTELLIGENCE SYSTEMS FOR UPPER GASTROINTESTINAL BLEEDING ON CLINICIAN TRUST AND LEARNING USING LARGE LANGUAGE MODELS: A RANDOMIZED PILOT SIMULATION STUDY. Gastroenterology 2024, 166: s-95-s-96. DOI: 10.1016/s0016-5085(24)00715-7.
- Rajashekar N, Chan C, Deutsch J, Laine L, Shung D. Tu1649 SIMULATING THE PATIENT-PRACTITIONER RELATIONSHIP IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH LARGE LANGUAGE MODELBASED TOOLS – A PROOF OF CONCEPT. Gastroenterology 2024, 166: s-1364. DOI: 10.1016/s0016-5085(24)03586-8.
- Zheng N, Keloth V, You K, Li D, Xu H, Laine L, Shung D. 1244 AUTOMATED IDENTIFICATION OF RECURRENT GASTROINTESTINAL BLEEDING USING ELECTRONIC HEALTH RECORDS AND LARGE LANGUAGE MODELS. Gastroenterology 2024, 166: s-292. DOI: 10.1016/s0016-5085(24)01152-1.
- Zheng N, Keloth V, You K, Li D, Xu H, Laine L, Shung D. 543 IDENTIFYING OVERT SIGNS OF ACUTE GASTROINTESTINAL BLEEDING IN THE ELECTRONIC HEALTH RECORD WITH LARGE LANGUAGE MODELS. Gastroenterology 2024, 166: s-124-s-125. DOI: 10.1016/s0016-5085(24)00776-5.
- Dupont J, Giuffrè M, Zhong J, You K, Laine L, Shung D. Tu2035 DEEP LEARNING TO CLASSIFY ENDOSCOPIC STIGMATA FOR PATIENTS WITH ACUTE UPPER GASTROINTESTINAL BLEEDING. Gastroenterology 2024, 166: s-1502. DOI: 10.1016/s0016-5085(24)03892-7.
- Spechler S, Laine L, Devault K, Smith N, Leifke E, Nabulsi A, Hunt B, Katz P. Mo1281 COMPARISON OF LOCAL INVESTIGATOR-REPORTED VS CENTRALLY ADJUDICATED LOS ANGELES GRADES OF EROSIVE ESOPHAGITIS IN PATIENTS SCREENED FOR PARTICIPATION IN A RANDOMIZED TRIAL. Gastroenterology 2024, 166: s-1011-s-1012. DOI: 10.1016/s0016-5085(24)02800-2.
- Dupont J, Giuffrè M, Zheng N, Laine L, Shung D. Tu1390 VALIDATION OF A MULTIMODAL MACHINE LEARNING MODEL FOR POST-ENDOSCOPIC RISK STRATIFICATION IN ACUTE UPPER GASTROINTESTINAL BLEEDING. Gastroenterology 2024, 166: s-1327-s-1328. DOI: 10.1016/s0016-5085(24)03494-2.
- Laine L, Spechler S, Yadlapati R, Schnoll-Sussman F, Smith N, Leifke E, Harris T, Hunt B, Fass R, Katz P. 864 VONOPRAZAN FOR THE TREATMENT OF HEARTBURN IN NON-EROSIVE REFLUX DISEASE: A RANDOMIZED TRIAL. Gastroenterology 2024, 166: s-198. DOI: 10.1016/s0016-5085(24)00949-1.
- Laine L, Barkun A, Leontiadis G. Letter to the Editor: Endoscopy for potential variceal bleeding within 12 hours—Not so fast! Hepatology 2024, 80: e15-e16. PMID: 38607699, DOI: 10.1097/hep.0000000000000876.
- Kurlander J, Laine L, Kim H, Roberts C, Saffar D, Myers A, Holleman R, Gao Y, Shank M, Nelson R, Forman J, Helfrich C, Krein S, Saini S, Yang Y. Impact of large scale, multicomponent intervention to reduce proton pump inhibitor overuse in integrated healthcare system: difference-in-difference study. The BMJ 2024, 385: e076484. PMID: 38604668, PMCID: PMC11007585, DOI: 10.1136/bmj-2023-076484.
- Shung D, Laine L. Review article: Upper gastrointestinal bleeding – review of current evidence and implications for management. Alimentary Pharmacology & Therapeutics 2024, 59: 1062-1081. PMID: 38517201, DOI: 10.1111/apt.17949.
- Nagula S, Parasa S, Laine L, Shah S. AGA Clinical Practice Update on High-Quality Upper Endoscopy: Expert Review. Clinical Gastroenterology And Hepatology 2024, 22: 933-943. PMID: 38385942, DOI: 10.1016/j.cgh.2023.10.034.
- Shung D, Laine L. Chapter 2 Data access, data bias, data equity. 2024, 13-26. DOI: 10.1016/b978-0-323-95068-8.00002-9.
- Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Clinical predictive value of renalase in post-ERCP pancreatitis. Gastrointestinal Endoscopy 2023, 99: 822-825.e1. PMID: 38103747, DOI: 10.1016/j.gie.2023.12.020.
- Shung D, Lin J, Laine L. Achieving Value by Risk Stratification With Machine Learning Model or Clinical Risk Score in Acute Upper Gastrointestinal Bleeding: A Cost Minimization Analysis. The American Journal Of Gastroenterology 2023, 119: 371-373. PMID: 37753930, PMCID: PMC10872988, DOI: 10.14309/ajg.0000000000002520.
- Laine L. Management of Bleeding Due to Small-Intestinal Angiodysplasias. New England Journal Of Medicine 2023, 389: 1718-1720. PMID: 37913510, DOI: 10.1056/nejme2310338.
- Restrepo D, Doshi R, Nawaz A, Chaar A, Kothari T, Laine L, Muniraj T. S11 Cholecystectomy Reduces the Odds of Inpatient Mortality in Patients With Acute Biliary Pancreatitis. The American Journal Of Gastroenterology 2023, 118: s9-s10. DOI: 10.14309/01.ajg.0000949684.33264.0a.
- Li D, Laine L, Shung D. Trends in Upper Gastrointestinal Bleeding in Patients on Primary Prevention Aspirin: A Nationwide Emergency Department Sample Analysis, 2016-2020. The American Journal Of Medicine 2023, 136: 1179-1186.e1. PMID: 37696350, PMCID: PMC10841721, DOI: 10.1016/j.amjmed.2023.08.010.
- Nawaz A, Chaar A, Rizwan R, Fetene J, Restrepo D, Alchirazi K, Abdulkarim D, Khalid F, Mathialagan K, Cheung M, Laine L, Muniraj T. Su1920 IMPACT OF OBESITY AND MORBID OBESITY ON OUTCOMES OF PATIENTS UNDERGOING ENDOSCOPIC PANCREATIC NECRESECTOMY. Gastroenterology 2023, 164: s-714. DOI: 10.1016/s0016-5085(23)02660-4.
- Nawaz A, Chaar A, Rizwan R, Restrepo D, Fetene J, Alchirazi K, Abdulkarim D, Khalid F, Doshi R, Mathialagan K, Hung K, Laine L, Muniraj T. Sa1420 FRAILTY IS ASSOCIATED WITH POOR OUTCOMES IN PATIENTS ADMITTED FOR ACUTE NECROTIZING PANCREATITIS. Gastroenterology 2023, 164: s-390. DOI: 10.1016/s0016-5085(23)01905-4.
- Chey W, Mégraud F, Laine L, Smith N, Leifke E, Hunt B, Howden C. Sa1373 HELICOBACTER PYLORI ERADICATION RATES WITH VONOPRAZAN: SUBGROUP ANALYSIS FROM THE PHASE 3 PHALCON HP TRIAL. Gastroenterology 2023, 164: s-378. DOI: 10.1016/s0016-5085(23)01877-2.
- Laine L, Hecht G. Presentation of the Julius M. Friedenwald Medal to Sheila E. Crowe, MD. Gastroenterology 2023, 164: 1324-1328. PMID: 37061896, DOI: 10.1053/j.gastro.2023.03.212.
- Wang M, Weiss F, Guo X, Kolodecik T, Bewersdorf J, Laine L, Lerch M, Desir G, Gorelick F. Plasma renalase levels are associated with the development of acute pancreatitis. Pancreatology 2023, 23: 158-162. PMID: 36697349, PMCID: PMC11847554, DOI: 10.1016/j.pan.2023.01.001.
- Li D, Ong S, Hughes M, Hung K, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2022, 57: 94-102. PMID: 36394111, DOI: 10.1111/apt.17278.
- Laine L, DeVault K, Katz P, Mitev S, Lowe J, Hunt B, Spechler S. Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial. Gastroenterology 2022, 164: 61-71. PMID: 36228734, DOI: 10.1053/j.gastro.2022.09.041.
- Rodriguez NJ, Zheng N, Mezzacappa C, Canavan M, Laine L, Shung D. Disparities in Access to Endoscopy for Patients With Upper Gastrointestinal Bleeding Presenting to Emergency Departments. Gastroenterology 2022, 164: 1044-1046.e4. PMID: 36228735, PMCID: PMC10083188, DOI: 10.1053/j.gastro.2022.10.001.
- Zheng NS, Tsay C, Laine L, Shung DL. Trends in characteristics, management, and outcomes of patients presenting with gastrointestinal bleeding to emergency departments in the United States from 2006 to 2019. Alimentary Pharmacology & Therapeutics 2022, 56: 1543-1555. PMID: 36173090, PMCID: PMC9669230, DOI: 10.1111/apt.17238.
- Laursen S, Stanley A, Laine L, de Muckadell O. Rebleeding in peptic ulcer bleeding – a nationwide cohort study of 19,537 patients. Scandinavian Journal Of Gastroenterology 2022, 57: 1423-1429. PMID: 35853234, DOI: 10.1080/00365521.2022.2098050.
- Kurlander JE, Barnes GD, Fisher A, Gonzalez JJ, Helminski D, Saini SD, Sengupta N, Yang YX, Scheiman J, Laine L. Association of Antisecretory Drugs with Upper Gastrointestinal Bleeding in Patients Using Oral Anticoagulants: A Systematic Review and Meta-Analysis. The American Journal Of Medicine 2022, 135: 1231-1243.e8. PMID: 35679879, PMCID: PMC10031639, DOI: 10.1016/j.amjmed.2022.05.031.
- Chey WD, Mégraud F, Laine L, López LJ, Hunt BJ, Howden CW. Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial. Gastroenterology 2022, 163: 608-619. PMID: 35679950, DOI: 10.1053/j.gastro.2022.05.055.
- Tham JE, Lynch L, Laursen SB, Laine L, Dalton HR, Ngu J, Redondo-Cerezo E, Schultz M, Murray I, Michell N, Morris AJ, Nielsen MM, Stanley AJ. International multicenter study comparing demographics, therapy and outcomes in bleeding from Mallory Weiss tears and peptic ulcers. Endoscopy International Open 2022, 10: e653-e658. PMID: 35571482, PMCID: PMC9106442, DOI: 10.1055/a-1784-0655.
- Abraham NS, Barkun AN, Sauer BG, Douketis J, Laine L, Noseworthy PA, Telford JJ, Leontiadis GI. American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period. The American Journal Of Gastroenterology 2022, 117: 542-558. PMID: 35297395, PMCID: PMC8966740, DOI: 10.14309/ajg.0000000000001627.
- Abraham NS, Barkun AN, Sauer BG, Douketis J, Laine L, Noseworthy PA, Telford JJ, Leontiadis GI. American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period. Journal Of The Canadian Association Of Gastroenterology 2022, 5: 100-101. PMID: 35368325, PMCID: PMC8972207, DOI: 10.1093/jcag/gwac010.
- Laine L, Sharma P, Mulford DJ, Hunt B, Leifke E, Smith N, Howden CW. Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects. The American Journal Of Gastroenterology 2022, 117: 1158-1161. PMID: 35294415, DOI: 10.14309/ajg.0000000000001735.
- Barkun AN, Douketis J, Noseworthy PA, Laine L, Telford JJ, Abraham NS. Management of Patients on Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Peri-Endoscopic Period: A Clinical Practice Guideline Dissemination Tool. The American Journal Of Gastroenterology 2022, 117: 513-519. PMID: 35354773, DOI: 10.14309/ajg.0000000000001688.
- Gastroinestinal BleedingLaine L. Gastroinestinal Bleeding in Harrison’s Principles of Internal Medicine, 21st Edition. Loscalzo J, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson LJ, Eds. McGraw-Hill Education. 2022; pp. 311-5.
- Gerasimiuk M, Shung D, Tong A, Stanley A, Schultz M, Ngu J, Laine L, Wolf G, Krishnaswamy S. MURAL: An Unsupervised Random Forest-Based Embedding for Electronic Health Record Data. 2021, 00: 4694-4704. DOI: 10.1109/bigdata52589.2021.9672045.
- Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology HospitalistsHughes ML, Li DK, Hung KW, Laine L. Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology Hospitalists. The American Journal Of Gastroenterology 2021, 117: 361-363. PMID: 34904965, DOI: 10.14309/ajg.0000000000001585.
- Zakko A, Zakko L, Grimshaw AA, Laine L. Antiplatelet Monotherapy Is Associated with an Increased Risk of Bleeding After Endoscopic Sphincterotomy. Digestive Diseases And Sciences 2021, 67: 4161-4169. PMID: 34796411, DOI: 10.1007/s10620-021-07302-w.
- Bittl JA, Laine L. Gastrointestinal Injury Caused by Aspirin or Clopidogrel Monotherapy Versus Dual Antiplatelet Therapy ∗. Journal Of The American College Of Cardiology 2021, 79: 129-131. PMID: 34752903, DOI: 10.1016/j.jacc.2021.10.027.
- Sandborn WJ, Feagan BG, D'Haens G, Wolf DC, Jovanovic I, Hanauer SB, Ghosh S, Petersen A, Hua SY, Lee JH, Charles L, Chitkara D, Usiskin K, Colombel JF, Laine L, Danese S. Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis. New England Journal Of Medicine 2021, 385: 1280-1291. PMID: 34587385, DOI: 10.1056/nejmoa2033617.
- Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI. Correction to: ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding. The American Journal Of Gastroenterology 2021, 116: 2309-2309. PMID: 34732677, DOI: 10.14309/ajg.0000000000001506.
- Tran AN, Wang M, Hundt M, Chugh R, Ohm J, Grimshaw A, Ciarleglio M, Hung KW, Proctor DD, Price CC, Laine L, Al-Bawardy B. Immune Checkpoint Inhibitor–associated Diarrhea and Colitis: A Systematic Review and Meta-analysis of Observational Studies. Journal Of Immunotherapy 2021, 44: 325-334. PMID: 34380976, DOI: 10.1097/cji.0000000000000383.
- Jensen DM, Barkun A, Cave D, Gralnek IM, Jutabha R, Laine L, Lau JYW, Saltzman JR, Soetikno R, Sung JJY. Acute gastrointestinal bleeding: proposed study outcomes for new randomised controlled trials. Alimentary Pharmacology & Therapeutics 2021, 54: 616-626. PMID: 34288017, PMCID: PMC9385213, DOI: 10.1111/apt.16483.
- Mohanty A, Kapuria D, Canakis A, Lin H, Amat MJ, Paniz G, Placone NT, Thomasson R, Roy H, Chak E, Baffy G, Curry MP, Laine L, Rustagi T. Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study. Liver International 2021, 41: 1901-1908. PMID: 33969607, DOI: 10.1111/liv.14936.
- Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI. ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding. The American Journal Of Gastroenterology 2021, 116: 899-917. PMID: 33929377, DOI: 10.14309/ajg.0000000000001245.
- Shung D, Huang J, Castro E, Tay JK, Simonov M, Laine L, Batra R, Krishnaswamy S. Neural network predicts need for red blood cell transfusion for patients with acute gastrointestinal bleeding admitted to the intensive care unit. Scientific Reports 2021, 11: 8827. PMID: 33893364, PMCID: PMC8065139, DOI: 10.1038/s41598-021-88226-3.
- Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies. World Journal Of Gastroenterology 2021, 27: 1630-1642. PMID: 33958848, PMCID: PMC8058652, DOI: 10.3748/wjg.v27.i15.1630.
- Sung JJY, Laine L, Kuipers EJ, Barkun AN. Towards personalised management for non-variceal upper gastrointestinal bleeding. Gut 2021, 70: 818-824. PMID: 33649044, DOI: 10.1136/gutjnl-2020-323846.
- Kelly CR, Wu GD, Laine LA. Reply. Gastroenterology 2021, 160: 2636. PMID: 33639155, DOI: 10.1053/j.gastro.2021.02.045.
- Shung D, Tsay C, Laine L, Chang D, Li F, Thomas P, Partridge C, Simonov M, Hsiao A, Tay JK, Taylor A. Early identification of patients with acute gastrointestinal bleeding using natural language processing and decision rules. Journal Of Gastroenterology And Hepatology 2021, 36: 1590-1597. PMID: 33105045, PMCID: PMC11874507, DOI: 10.1111/jgh.15313.
- Dawwas GK, Brensinger CM, Vajravelu RK, Wu Q, Kelly CR, Laine L, Wu GD, Lewis JD. Long-term Outcomes Following Multiply Recurrent Clostridioides difficile Infection and Fecal Microbiota Transplantation. Clinical Gastroenterology And Hepatology 2020, 20: 806-816.e6. PMID: 33307184, PMCID: PMC8184854, DOI: 10.1016/j.cgh.2020.12.004.
- Kelly CR, Yen EF, Grinspan AM, Kahn SA, Atreja A, Lewis JD, Moore TA, Rubin DT, Kim AM, Serra S, Nersesova Y, Fredell L, Hunsicker D, McDonald D, Knight R, Allegretti JR, Pekow J, Absah I, Hsu R, Vincent J, Khanna S, Tangen L, Crawford CV, Mattar MC, Chen LA, Fischer M, Arsenescu RI, Feuerstadt P, Goldstein J, Kerman D, Ehrlich AC, Wu GD, Laine L. Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry. Gastroenterology 2020, 160: 183-192.e3. PMID: 33011173, PMCID: PMC8034505, DOI: 10.1053/j.gastro.2020.09.038.
- Vyas M, Celli R, Singh M, Patel N, Aslanian HR, Boffa D, Deng Y, Ciarleglio MM, Laine L, Jain D. Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction. Human Pathology 2020, 105: 67-73. PMID: 32941964, PMCID: PMC11152084, DOI: 10.1016/j.humpath.2020.08.007.
- Kelly CR, Laine LA, Wu GD. Monitoring Fecal Microbiota Transplantation Practice in a Rapidly Evolving Health and Regulatory Environment. Gastroenterology 2020, 159: 2004-2006. PMID: 32841646, PMCID: PMC7443160, DOI: 10.1053/j.gastro.2020.08.039.
- Laursen SB, Oakland K, Laine L, Bieber V, Marmo R, Redondo-Cerezo E, Dalton HR, Ngu J, Schultz M, Soncini M, Gralnek I, Jairath V, Murray IA, Stanley AJ. ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicentre study. Gut 2020, 70: 707-716. PMID: 32723845, DOI: 10.1136/gutjnl-2019-320002.
- Shung D, Laine L. Machine Learning Prognostic Models for Gastrointestinal Bleeding Using Electronic Health Record Data. The American Journal Of Gastroenterology 2020, 115: 1199-1200. PMID: 32530828, PMCID: PMC7415736, DOI: 10.14309/ajg.0000000000000720.
- Kelly C, Yen E, Grinspan A, Kahn S, Atreja A, Lewis J, Moore T, Rubin D, Kim A, Serra S, Nersesova Y, Fredell L, Hunsicker D, McDonald D, Knight R, Allegretti J, Pekow J, Absah I, Hsu R, Vincent J, Khanna S, Tangen L, Crawford C, Mattar M, Chen L, Fischer M, Arsenescu R, Wu G, Laine L. 37 FECAL MICROBIOTA TRANSPLANATION IS HIGHLY EFFECTIVE IN REAL-WORLD PRACTICE: INITIAL RESULTS FROM THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION FECAL MICROBIOTA TRANSPLANTATION NATIONAL REGISTRY. Gastroenterology 2020, 158: s-14-s-15. DOI: 10.1016/s0016-5085(20)30717-4.
- Barkun AN, Laine L, Leontiadis GI, Bardou M. Management of Nonvariceal Upper Gastrointestinal Bleeding. Annals Of Internal Medicine 2020, 172: 573. PMID: 32311706, DOI: 10.7326/l20-0014.
- Laine L. Timing of Endoscopy in Patients Hospitalized with Upper Gastrointestinal Bleeding. New England Journal Of Medicine 2020, 382: 1361-1363. PMID: 32242363, DOI: 10.1056/nejme2002121.
- Simonov M, Abel EA, Skanderson M, Masoud A, Hauser RG, Brandt CA, Wilson FP, Laine L. Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones. Clinical Gastroenterology And Hepatology 2020, 19: 72-79.e21. PMID: 32147588, PMCID: PMC7483196, DOI: 10.1016/j.cgh.2020.02.053.
- Campbell EV, Muniraj T, Aslanian HR, Laine L, Jamidar P. Musculoskeletal Pain Symptoms and Injuries Among Endoscopists Who Perform ERCP. Digestive Diseases And Sciences 2020, 66: 56-62. PMID: 32144599, DOI: 10.1007/s10620-020-06163-z.
- Laine L, Kaltenbach T, Barkun A, Soetikno R. Chromoendoscopy meta-analysis: correcting subgroup analysis interpretation. Gastrointestinal Endoscopy 2020, 91: 719. PMID: 32087902, DOI: 10.1016/j.gie.2019.08.041.
- Kurlander JE, Rubenstein JH, Richardson CR, Krein SL, De Vries R, Zikmund-Fisher BJ, Yang YX, Laine L, Weissman A, Saini SD. Physicians' Perceptions of Proton Pump Inhibitor Risks and Recommendations to Discontinue: A National Survey. The American Journal Of Gastroenterology 2020, 115: 689-696. PMID: 32091419, PMCID: PMC7196016, DOI: 10.14309/ajg.0000000000000558.
- Lee MW, Pourmorady JS, Laine L. Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2020, 115: 662-670. PMID: 31972617, DOI: 10.14309/ajg.0000000000000495.
- Tsay C, Shung D, Stemmer Frumento K, Laine L. Early Colonoscopy Does Not Improve Outcomes of Patients With Lower Gastrointestinal Bleeding: Systematic Review of Randomized Trials. Clinical Gastroenterology And Hepatology 2019, 18: 1696-1703.e2. PMID: 31843595, PMCID: PMC7292779, DOI: 10.1016/j.cgh.2019.11.061.
- Laine L. Colonoscopy for Lower Gastrointestinal Bleeding—Time Is Not of the Essence. Gastroenterology 2019, 158: 38-39. PMID: 31730767, DOI: 10.1053/j.gastro.2019.11.009.
- Saffouri E, Blackwell C, Laursen SB, Laine L, Dalton HR, Ngu J, Shultz M, Norton R, Stanley AJ. The Shock Index is not accurate at predicting outcomes in patients with upper gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2019, 51: 253-260. PMID: 31642558, DOI: 10.1111/apt.15541.
- Barkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, Leontiadis GI, Abraham NS, Calvet X, Chan FKL, Douketis J, Enns R, Gralnek IM, Jairath V, Jensen D, Lau J, Lip GYH, Loffroy R, Maluf-Filho F, Meltzer AC, Reddy N, Saltzman JR, Marshall JK, Bardou M. Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group. Annals Of Internal Medicine 2019, 171: 805-822. PMID: 31634917, PMCID: PMC7233308, DOI: 10.7326/m19-1795.
- Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD. Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn. New England Journal Of Medicine 2019, 381: 1513-1523. PMID: 31618539, DOI: 10.1056/nejmoa1811424.
- Shung DL, Au B, Taylor RA, Tay JK, Laursen SB, Stanley AJ, Dalton HR, Ngu J, Schultz M, Laine L. Validation of a Machine Learning Model That Outperforms Clinical Risk Scoring Systems for Upper Gastrointestinal Bleeding. Gastroenterology 2019, 158: 160-167. PMID: 31562847, PMCID: PMC7004228, DOI: 10.1053/j.gastro.2019.09.009.
- Redondo‐Cerezo E, Vadillo‐Calles F, Stanley AJ, Laursen S, Laine L, Dalton HR, Ngu JH, Schultz M, Jiménez‐Rosales R. MAP(ASH): A new scoring system for the prediction of intervention and mortality in upper gastrointestinal bleeding. Journal Of Gastroenterology And Hepatology 2019, 35: 82-89. PMID: 31359521, DOI: 10.1111/jgh.14811.
- Shung D, Simonov M, Gentry M, Au B, Laine L. Machine Learning to Predict Outcomes in Patients with Acute Gastrointestinal Bleeding: A Systematic Review. Digestive Diseases And Sciences 2019, 64: 2078-2087. PMID: 31055722, DOI: 10.1007/s10620-019-05645-z.
- Laine L, Ganz RA. Presentation of the Julius M. Friedenwald Medal to John I. Allen. Gastroenterology 2019, 156: 2330-2334. PMID: 31029707, DOI: 10.1053/j.gastro.2019.04.026.
- Laine L. Interventions for Primary Prevention of Esophageal Variceal Bleeding. Hepatology 2019, 69: 1382-1384. PMID: 30561058, DOI: 10.1002/hep.30463.
- Stanley AJ, Laine L. Management of acute upper gastrointestinal bleeding. The BMJ 2019, 364: l536. PMID: 30910853, DOI: 10.1136/bmj.l536.
- Singh M, Sacatos M, Laine L. Impact of Changeover to Newer Endoscopic Systems on Quality and Efficiency of Screening and Surveillance Colonoscopy. Journal Of Clinical Gastroenterology 2018, 52: 891-895. PMID: 28906425, DOI: 10.1097/mcg.0000000000000931.
- Laine L, Laursen SB, Stanley AJ. Outcomes with Bloody vs. Coffee-Grounds Hematemesis. The American Journal Of Gastroenterology 2018, 113: 1727-1728. PMID: 30333532, DOI: 10.1038/s41395-018-0359-2.
- Laine L. Treatment of thrombocytopenic patients with GI bleeding. Gastrointestinal Endoscopy 2018, 88: 62-65. PMID: 29935628, DOI: 10.1016/j.gie.2018.03.003.
- Laine L, Laursen SB, Stanley AJ. Analyses of Bloody vs. Coffee-Grounds Hematemesis. The American Journal Of Gastroenterology 2018, 113: 1253-1254. PMID: 29955117, DOI: 10.1038/s41395-018-0188-3.
- Laine L. Editorial: gastrointestinal safety of COX‐2 selective and nonselective NSAIDs—the impact of the PRECISION trial. Alimentary Pharmacology & Therapeutics 2018, 47: 1545-1546. PMID: 29878414, DOI: 10.1111/apt.14642.
- Dunne P, Laursen SB, Laine L, Dalton HR, Ngu JH, Schultz M, Rahman A, Anderloni A, Murray IA, Stanley AJ. Previous Use of Antithrombotic Agents Reduces Mortality and Length of Hospital Stay in Patients With High-risk Upper Gastrointestinal Bleeding. Clinical Gastroenterology And Hepatology 2018, 17: 440-447.e2. PMID: 29705263, DOI: 10.1016/j.cgh.2018.04.046.
- Scally B, Emberson JR, Spata E, Reith C, Davies K, Halls H, Holland L, Wilson K, Bhala N, Hawkey C, Hochberg M, Hunt R, Laine L, Lanas A, Patrono C, Baigent C. Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: a meta-analysis of randomised trials. The Lancet Gastroenterology & Hepatology 2018, 3: 231-241. PMID: 29475806, PMCID: PMC5842491, DOI: 10.1016/s2468-1253(18)30037-2.
- Laine L, Laursen SB, Zakko L, Dalton HR, Ngu JH, Schultz M, Stanley AJ. Severity and Outcomes of Upper Gastrointestinal Bleeding With Bloody Vs. Coffee-Grounds Hematemesis. The American Journal Of Gastroenterology 2018, 113: 358. PMID: 29380820, DOI: 10.1038/ajg.2018.5.
- Parikh ND, Viana AV, Shah S, Laine L. Image-enhanced endoscopy is specific for the diagnosis of non-erosive gastroesophageal reflux disease. Scandinavian Journal Of Gastroenterology 2018, 53: 260-264. PMID: 29368532, PMCID: PMC6080852, DOI: 10.1080/00365521.2018.1430847.
- Gastroinestinal BleedingLaine L. Gastroinestinal Bleeding in Harrison’s Principles of Internal Medicine, 20th Edition. Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J, Eds. McGraw-Hill Education. 2018; pp. 272-6.
- Buxbaum J, Sahakian A, Ko C, Jayaram P, Lane C, Yu CY, Kankotia R, Laine L. Randomized trial of cholangioscopy-guided laser lithotripsy versus conventional therapy for large bile duct stones (with videos). Gastrointestinal Endoscopy 2017, 87: 1050-1060. PMID: 28866457, DOI: 10.1016/j.gie.2017.08.021.
- Lu Y, Jones DJ, Sharara N, Kaltenbach T, Laine L, McQuaid K, Soetikno R, Subramanian V, Barkun A. Transparency ethics in practice: Revisiting financial conflicts of interest disclosure forms in clinical practice guidelines. PLOS ONE 2017, 12: e0182856. PMID: 28841650, PMCID: PMC5571907, DOI: 10.1371/journal.pone.0182856.
- Kaltenbach TR, Soetikno RM, DeVivo R, Laine LA, Barkun A, McQuaid KR, Group O, Cheifetz A, Chiorean M, East J, Farraye F, Leighton J, Levesque B, Lichtenstein G, Marion J, Matsumoto T, Mönkemüller K, Picco M, Odze R, Raju G, Rutter M, Rex D, Shen B, Shergill A, Subramanian V. Optimizing the quality of endoscopy in inflammatory bowel disease: focus on surveillance and management of colorectal dysplasia using interactive image- and video-based teaching. Gastrointestinal Endoscopy 2017, 86: 1107-1117.e1. PMID: 28818507, DOI: 10.1016/j.gie.2017.07.045.
- Laine L. Is there a role for combined sclerotherapy and ligation in the endoscopic treatment of gastroesophageal varices? Gastrointestinal Endoscopy 2017, 86: 316-318. PMID: 28728669, DOI: 10.1016/j.gie.2017.02.005.
- Hou LA, Laine L, Motamedi N, Sahakian A, Lane C, Buxbaum J. Optimal Timing of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis. Journal Of Clinical Gastroenterology 2017, 51: 534-538. PMID: 27875357, DOI: 10.1097/mcg.0000000000000763.
- Kim SJ, Ohanian E, Lee F, Nam B, Che K, Laine L, Kim SE, Kim JJ. Predictors and outcomes of delayed plastic biliary stent removal following endoscopic retrograde cholangiopancreatography. Scandinavian Journal Of Gastroenterology 2017, 52: 1128-1132. PMID: 28657377, DOI: 10.1080/00365521.2017.1342138.
- Laine L. Bleeding With Direct Oral Anticoagulants: The Gastrointestinal Tract and Beyond. Clinical Gastroenterology And Hepatology 2017, 15: 1665-1667. PMID: 28666949, DOI: 10.1016/j.cgh.2017.06.041.
- Gupta N, Brill JV, Canto M, DeMarco D, Fennerty BM, Laine L, Lieberman D, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Tokar JL, Kochman ML. AGA White Paper: Training and Implementation of Endoscopic Image Enhancement Technologies. Clinical Gastroenterology And Hepatology 2017, 15: 820-826. PMID: 28528939, DOI: 10.1016/j.cgh.2017.01.033.
- Laine L, Laursen SB, Dalton HR, Ngu JH, Schultz M, Stanley AJ. Relationship of time to presentation after onset of upper GI bleeding with patient characteristics and outcomes: a prospective study. Gastrointestinal Endoscopy 2017, 86: 1028-1037. PMID: 28396275, DOI: 10.1016/j.gie.2017.03.1549.
- Buxbaum JL, Hormozdi D, Dinis-Ribeiro M, Lane C, Dias-Silva D, Sahakian A, Jayaram P, Pimentel-Nunes P, Shue D, Pepper M, Cho D, Laine L. Narrow-band imaging versus white light versus mapping biopsy for gastric intestinal metaplasia: a prospective blinded trial. Gastrointestinal Endoscopy 2017, 86: 857-865. PMID: 28366441, DOI: 10.1016/j.gie.2017.03.1528.
- Buxbaum JL, Quezada M, Da B, Jani N, Lane C, Mwengela D, Kelly T, Jhun P, Dhanireddy K, Laine L. Early Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis. The American Journal Of Gastroenterology 2017, 112: 797. PMID: 28266591, DOI: 10.1038/ajg.2017.40.
- Sachar H, Pichetshote N, Nandigam K, Vaidya K, Laine L. Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial. Gastrointestinal Endoscopy 2017, 87: 1297-1303. PMID: 28159539, PMCID: PMC5537051, DOI: 10.1016/j.gie.2017.01.028.
- Kelly CR, Kim AM, Laine L, Wu GD. The AGA’s Fecal Microbiota Transplantation National Registry: An Important Step Toward Understanding Risks and Benefits of Microbiota Therapeutics. Gastroenterology 2017, 152: 681-684. PMID: 28143773, DOI: 10.1053/j.gastro.2017.01.028.
- Stanley AJ, Laine L, Dalton HR, Ngu JH, Schultz M, Abazi R, Zakko L, Thornton S, Wilkinson K, Khor CJ, Murray IA, Laursen SB. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study. The BMJ 2017, 356: i6432. PMID: 28053181, PMCID: PMC5217768, DOI: 10.1136/bmj.i6432.
- Park S, Abdi T, Gentry M, Laine L. Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2016, 111: 1692. PMID: 27725645, DOI: 10.1038/ajg.2016.418.
- Laine L. Upper Gastrointestinal Bleeding Due to a Peptic Ulcer. New England Journal Of Medicine 2016, 375: 1197-1198. PMID: 27653581, DOI: 10.1056/nejmc1609017.
- Laine L. Risk Assessment Tools for Gastrointestinal Bleeding. Clinical Gastroenterology And Hepatology 2016, 14: 1571-1573. PMID: 27521511, DOI: 10.1016/j.cgh.2016.08.003.
- Sheibani S, Khemichian S, Kim JJ, Hou L, Yan AW, Buxbaum J, Dara L, Laine L. Randomized trial of 1‐week versus 2‐week intervals for endoscopic ligation in the treatment of patients with esophageal variceal bleeding. Hepatology 2016, 64: 549-555. PMID: 27082942, PMCID: PMC4956532, DOI: 10.1002/hep.28597.
- Zakko L, Rustagi T, Douglas M, Laine L. No Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents. Clinical Gastroenterology And Hepatology 2016, 15: 46-52. PMID: 27464591, DOI: 10.1016/j.cgh.2016.07.017.
- Buxbaum J, Leonor P, Tung J, Lane C, Sahakian A, Laine L. Randomized Trial of Endoscopist-Controlled vs. Assistant-Controlled Wire-Guided Cannulation of the Bile Duct. The American Journal Of Gastroenterology 2016, 111: 1841. PMID: 27377519, DOI: 10.1038/ajg.2016.268.
- Laine L. Upper Gastrointestinal Bleeding Due to a Peptic Ulcer. New England Journal Of Medicine 2016, 374: 2367-2376. PMID: 27305194, DOI: 10.1056/nejmcp1514257.
- Parikh ND, Chaptini L, Njei B, Laine L. Diagnosis of sessile serrated adenomas/polyps with image-enhanced endoscopy: a systematic review and meta-analysis. Endoscopy 2016, 48: 731-739. PMID: 27223636, DOI: 10.1055/s-0042-107592.
- Graham DY, Laine L. The Toronto Helicobacter pylori Consensus in Context. Gastroenterology 2016, 151: 9-12. PMID: 27215659, PMCID: PMC6910198, DOI: 10.1053/j.gastro.2016.05.009.
- Popov VB, Thompson CC, Kumar N, Ciarleglio MM, Deng Y, Laine L. Effect of Intragastric Balloons on Liver Enzymes: A Systematic Review and Meta-Analysis. Digestive Diseases And Sciences 2016, 61: 2477-2487. PMID: 27207181, DOI: 10.1007/s10620-016-4178-2.
- Park S, Laine L. Pursuing a Clinical Academic Career During Gastroenterology Fellowship. Digestive Diseases And Sciences 2016, 61: 2162-2164. PMID: 27193565, DOI: 10.1007/s10620-016-4196-0.
- Vaduganathan M, Cannon CP, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Bhatt DL, Investigators C. Efficacy and Safety of Proton-Pump Inhibitors in High-Risk Cardiovascular Subsets of the COGENT Trial. The American Journal Of Medicine 2016, 129: 1002-1005. PMID: 27143321, DOI: 10.1016/j.amjmed.2016.03.042.
- Laine L, Nagar A. Long-Term PPI Use: Balancing Potential Harms and Documented Benefits. The American Journal Of Gastroenterology 2016, 111: 913. PMID: 27113114, DOI: 10.1038/ajg.2016.156.
- Clark BT, Laine L. High-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps. Clinical Gastroenterology And Hepatology 2016, 14: 1155-1162. PMID: 27060426, PMCID: PMC4955697, DOI: 10.1016/j.cgh.2016.03.044.
- Soetikno R, Kaltenbach T, McQuaid KR, Subramanian V, Kumar R, Barkun AN, Laine L. Paradigm Shift in the Surveillance and Management of Dysplasia in Inflammatory Bowel Disease (West). Digestive Endoscopy 2016, 28: 266-273. PMID: 26866420, DOI: 10.1111/den.12634.
- Vaduganathan M, Bhatt DL, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Cannon CP, Investigators C. Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. Journal Of The American College Of Cardiology 2016, 67: 1661-1671. PMID: 27012778, DOI: 10.1016/j.jacc.2015.12.068.
- Clark BT, Parikh ND, Laine L. Yield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy. Gastrointestinal Endoscopy 2016, 84: 126-132. PMID: 26769408, PMCID: PMC4912931, DOI: 10.1016/j.gie.2015.12.030.
- Langberg KM, Parikh ND, Deng Y, Ciarlegio M, Laine L, Aslanian HR. Digital chromoendoscopy utilization in clinical practice: A survey of gastroenterologists in Connecticut. World Journal Of Gastrointestinal Pharmacology And Therapeutics 2016, 7: 268-73. PMID: 27158543, PMCID: PMC4848250, DOI: 10.4292/wjgpt.v7.i2.268.
- Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR. Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP? Digestive Diseases And Sciences 2015, 61: 722-730. PMID: 26572779, DOI: 10.1007/s10620-015-3939-7.
- Rustagi T, Aslanian HR, Laine L. Treatment of Refractory Gastrointestinal Strictures With Mitomycin C. Journal Of Clinical Gastroenterology 2015, 49: 837-847. PMID: 25626632, DOI: 10.1097/mcg.0000000000000295.
- Sharma P, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lieberman D, Lightdale C, Montgomery E, Odze R, Tokar J, Kochman M. White Paper AGA: Advanced Imaging in Barrett’s Esophagus. Clinical Gastroenterology And Hepatology 2015, 13: 2209-2218. PMID: 26462567, DOI: 10.1016/j.cgh.2015.09.017.
- Clark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L. Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology 2015, 150: 396-405. PMID: 26439436, PMCID: PMC4728019, DOI: 10.1053/j.gastro.2015.09.041.
- Njei B, Laine L. Early Use of TIPS and Outcomes in Patients With Cirrhosis and Acute Esophageal Variceal Bleeding: Analysis of the U.S. Nationwide Inpatient Sample (NIS) Database, 2000-2010: ACG Fellows-In-Training Award. The American Journal Of Gastroenterology 2015, 110: s870. DOI: 10.14309/00000434-201510001-02070.
- He H, Tan C, Wu J, Dai N, Hu W, Scheiman J, Laine L, Kim J. Suboptimal Specificity of ASGE High-Risk Group in Evaluation of Patients With Suspected Choledocholithiasis. The American Journal Of Gastroenterology 2015, 110: s9. DOI: 10.14309/00000434-201510001-00018.
- Sanduleanu S, Kaltenbach T, Barkun A, McCabe RP, Velayos F, Picco MF, Laine L, Soetikno R, McQuaid KR. A roadmap to the implementation of chromoendoscopy in inflammatory bowel disease colonoscopy surveillance practice. Gastrointestinal Endoscopy 2015, 83: 213-222. PMID: 26364967, DOI: 10.1016/j.gie.2015.08.076.
- Lieberman D, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Kochman M, Tokar J. Management of Diminutive Colon Polyps Based on Endoluminal Imaging. Clinical Gastroenterology And Hepatology 2015, 13: 1860-1866. PMID: 26192139, DOI: 10.1016/j.cgh.2015.07.011.
- Vardi M, Cryer BL, Cohen M, Lanas A, Schnitzer TJ, Lapuerta P, Goldsmith MA, Laine L, Doros G, Liu Y, McIntosh AI, Cannon CP, Bhatt DL. The effects of proton pump inhibition on patient‐reported severity of dyspepsia when receiving dual anti‐platelet therapy with clopidogrel and low‐dose aspirin: analysis from the Clopidogrel and the Optimization of Gastrointestinal Events Trial. Alimentary Pharmacology & Therapeutics 2015, 42: 365-374. PMID: 26032114, PMCID: PMC4494867, DOI: 10.1111/apt.13260.
- Lee F, Ohanian E, Rheem J, Laine L, Che K, Kim JJ. Delayed endoscopic retrograde cholangiopancreatography is associated with persistent organ failure in hospitalised patients with acute cholangitis. Alimentary Pharmacology & Therapeutics 2015, 42: 212-220. PMID: 25997554, DOI: 10.1111/apt.13253.
- Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and OutlookKelly CR, Kahn S, Kashyap P, Laine L, Rubin D, Atreja A, Moore T, Wu G. Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook. Gastroenterology 2015, 149: 223-237. PMID: 25982290, PMCID: PMC4755303, DOI: 10.1053/j.gastro.2015.05.008.
- Yan K, Bridges J, Augustin S, Laine L, Garcia-Tsao G, Fraenkel L. Factors impacting physicians’ decisions to prevent variceal hemorrhage. BMC Gastroenterology 2015, 15: 55. PMID: 25934271, PMCID: PMC4423490, DOI: 10.1186/s12876-015-0287-1.
- Chaptini L, Laine L. Can I Improve My Adenoma Detection Rate? Journal Of Clinical Gastroenterology 2015, 49: 270-281. PMID: 25647725, DOI: 10.1097/mcg.0000000000000293.
- Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, Panel S, East J, Farraye F, Feagan B, Ioannidis J, Kiesslich R, Krier M, Matsumoto T, McCabe R, Mönkemüller K, Odze R, Picco M, Rubin D, Rubin M, Rubio C, Rutter M, Sanchez-Yague A, Sanduleanu S, Shergill A, Ullman T, Velayos F, Yakich D, Yang Y. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastrointestinal Endoscopy 2015, 81: 489-501.e26. PMID: 25708752, DOI: 10.1016/j.gie.2014.12.009.
- Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, Panel S, East J, Farraye F, Feagan B, Ioannidis J, Kiesslich R, Krier M, Matsumoto T, McCabe R, Mönkemüller K, Odze R, Picco M, Rubin D, Rubin M, Rubio C, Rutter M, Sanchez-Yague A, Sanduleanu S, Shergill A, Ullman T, Velayos F, Yakich D, Yang Y. SCENIC International Consensus Statement on Surveillance and Management of Dysplasia in Inflammatory Bowel Disease. Gastroenterology 2015, 148: 639-651.e28. PMID: 25702852, DOI: 10.1053/j.gastro.2015.01.031.
- Gastroinestinal BleedingLaine L. Gastroinestinal Bleeding in Gastrointestinal Bleeding. In Harrison’s Principles of Internal Medicine, 19th Edition. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, Eds. McGraw-Hill Education. 2015; pp. 276-9.
- Park WG, Shaheen NJ, Cohen J, Pike IM, Adler DG, Inadomi JM, Laine LA, Lieb JG, Rizk MK, Sawhney MS, Wani S. Quality indicators for EGD. Gastrointestinal Endoscopy 2014, 81: 17-30. PMID: 25480101, DOI: 10.1016/j.gie.2014.07.057.
- Park WG, Shaheen NJ, Cohen J, Pike IM, Adler DG, Inadomi JM, Laine LA, Lieb JG, Rizk MK, Sawhney MS, Wani S. Quality Indicators for EGD. The American Journal Of Gastroenterology 2014, 110: 60. PMID: 25448872, DOI: 10.1038/ajg.2014.384.
- Sachar H, Vaidya K, Laine L. Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis. JAMA Internal Medicine 2014, 174: 1755-1762. PMID: 25201154, PMCID: PMC4415726, DOI: 10.1001/jamainternmed.2014.4056.
- Kim JJ, Walia S, Lee SH, Patel B, Vetsa M, Zhao Y, Srikureja W, Laine L. Lower Yield of Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Patients with Pancreatic Head Mass with a Biliary Stent. Digestive Diseases And Sciences 2014, 60: 543-549. PMID: 25245115, DOI: 10.1007/s10620-014-3367-0.
- Laine L. NSAID-Associated Gastrointestinal Bleeding: Assessing the Role of Concomitant Medications. Gastroenterology 2014, 147: 730-733. PMID: 25167988, DOI: 10.1053/j.gastro.2014.08.021.
- Clark BT, Rustagi T, Laine L. What Level of Bowel Prep Quality Requires Early Repeat Colonoscopy: Systematic Review and Meta-Analysis of the Impact of Preparation Quality on Adenoma Detection Rate. The American Journal Of Gastroenterology 2014, 109: 1714. PMID: 25135006, PMCID: PMC4423726, DOI: 10.1038/ajg.2014.232.
- Chaptini L, Chaaya A, Depalma F, Hunter K, Peikin S, Laine L. Variation in polyp size estimation among endoscopists and impact on surveillance intervals. Gastrointestinal Endoscopy 2014, 80: 652-659. PMID: 24679658, DOI: 10.1016/j.gie.2014.01.053.
- Kim JJ, Lee JS, Olafsson S, Laine L. Low Adherence to Helicobacter pylori Testing in Hospitalized Patients with Bleeding Peptic Ulcer Disease. Helicobacter 2014, 19: 98-104. PMID: 24617668, DOI: 10.1111/hel.12114.
- Kim JJ, Sheibani S, Park S, Buxbaum J, Laine L. Causes of Bleeding and Outcomes in Patients Hospitalized With Upper Gastrointestinal Bleeding. Journal Of Clinical Gastroenterology 2014, 48: 113-118. PMID: 23685847, DOI: 10.1097/mcg.0b013e318297fb40.
- Kim JJ, Han A, Yan AW, Cao D, Laine L. Gastroenterologists’ Practice Patterns for Positive Fecal Occult Blood Test. Journal Of Clinical Gastroenterology 2014, 48: 119-126. PMID: 23632353, DOI: 10.1097/mcg.0b013e31828f1c8d.
- Sahakian AB, Aslanian HR, Mehra M, Rossi F, Laine L, Sanchez M, Ciarleglio MM, Adimoolam V, Siddiqui UD. The Utility of Esophagogastroduodenoscopy Before Endoscopic Ultrasonography in Patients Undergoing Endoscopic Ultrasonography for Pancreatico-biliary and Mediastinal Indications. Journal Of Clinical Gastroenterology 2013, 47: 857-860. PMID: 23632349, DOI: 10.1097/mcg.0b013e31828ba28c.
- Hecht GA, Blaser MJ, Gordon J, Kaplan LM, Knight R, Laine L, Peek R, Sanders ME, Sartor B, Wu GD, Yang VW. What Is the Value of a Food and Drug Administration Investigational New Drug Application for Fecal Microbiota Transplantation to Treat Clostridium difficile Infection? Clinical Gastroenterology And Hepatology 2013, 12: 289-291. PMID: 24148361, DOI: 10.1016/j.cgh.2013.10.009.
- Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, Bombardier C, Cannon C, Farkouh ME, FitzGerald GA, Goss P, Halls H, Hawk E, Hawkey C, Hennekens C, Hochberg M, Holland LE, Kearney PM, Laine L, Lanas A, Lance P, Laupacis A, Oates J, Patrono C, Schnitzer TJ, Solomon S, Tugwell P, Wilson K, Wittes J, Baigent C. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet 2013, 382: 769-79. PMID: 23726390, PMCID: PMC3778977, DOI: 10.1016/S0140-6736(13)60900-9.
- Buxbaum J, Yan A, Yeh K, Lane C, Nguyen N, Laine L. Aggressive Hydration With Lactated Ringer's Solution Reduces Pancreatitis After Endoscopic Retrograde Cholangiopancreatography. Clinical Gastroenterology And Hepatology 2013, 12: 303-307.e1. PMID: 23920031, PMCID: PMC3879172, DOI: 10.1016/j.cgh.2013.07.026.
- Saliminejad M, Bemanian S, Ho A, Spiegel B, Laine L. The yield and cost of colonoscopy in patients with metastatic cancer of unknown primary. Alimentary Pharmacology & Therapeutics 2013, 38: 628-633. PMID: 23869398, DOI: 10.1111/apt.12429.
- Sheibani S, Kim JJ, Chen B, Park S, Saberi B, Keyashian K, Buxbaum J, Laine L. Natural history of acute upper GI bleeding due to tumours: short‐term success and long‐term recurrence with or without endoscopic therapy. Alimentary Pharmacology & Therapeutics 2013, 38: 144-150. PMID: 23710797, DOI: 10.1111/apt.12347.
- Aslanian HR, Laine L. Hemostatic powder spray for GI bleeding. Gastrointestinal Endoscopy 2013, 77: 508-510. PMID: 23410702, DOI: 10.1016/j.gie.2012.11.034.
- de Groot NL, van Haalen HG, Spiegel BM, Laine L, Lanas A, Focks JJ, Siersema PD, van Oijen MG. Gastroprotection in Low-Dose Aspirin Users for Primary and Secondary Prevention of ACS: Results of a Cost-Effectiveness Analysis Including Compliance. Cardiovascular Drugs And Therapy 2013, 27: 341-357. PMID: 23417566, DOI: 10.1007/s10557-013-6448-y.
- Laine L. Blood Transfusion for Gastrointestinal Bleeding. New England Journal Of Medicine 2013, 368: 75-76. PMID: 23281980, DOI: 10.1056/nejme1212009.
- Kim J, Sara S, Sunhee P, Chen B, Buxbaum J, Laine L. High Frequency of Varices as a Cause of Upper GI Bleeding in Low-Socioeconomic-Status Patients. The American Journal Of Gastroenterology 2012, 107: s755-s756. DOI: 10.14309/00000434-201210001-01856.
- Enestvedt BK, Tofani C, Laine LA, Tierney A, Fennerty MB. 4-Liter Split-Dose Polyethylene Glycol Is Superior to Other Bowel Preparations, Based on Systematic Review and Meta-analysis. Clinical Gastroenterology And Hepatology 2012, 10: 1225-1231. PMID: 22940741, DOI: 10.1016/j.cgh.2012.08.029.
- Laine L, Kivitz A, Bello A, Grahn A, Schiff M, Taha A. Corrigendum: Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers. The American Journal Of Gastroenterology 2012, 107: 1272. DOI: 10.1038/ajg.2012.244.
- Laine L, Yang H, Chang SC, Datto C. Trends for Incidence of Hospitalization and Death Due to GI Complications in the United States From 2001 to 2009. The American Journal Of Gastroenterology 2012, 107: 1190. PMID: 22688850, DOI: 10.1038/ajg.2012.168.
- Dadabhai AS, Fenkel JM, Brown DB, Laine L. Balloon‐occluded retrograde transvenous obliteration for the treatment of gastric varices. Hepatology 2012, 55: 1301-1304. PMID: 22318957, DOI: 10.1002/hep.25635.
- Laine L, Jensen DM. Management of Patients With Ulcer Bleeding. The American Journal Of Gastroenterology 2012, 107: 345. PMID: 22310222, DOI: 10.1038/ajg.2011.480.
- Gastroinestinal BleedingLaine L. Gastroinestinal Bleeding in Harrison’s Principles of Internal Medicine, 18th Edition. Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, Eds. The McGraw-Hill Companies, Inc. 2012; pp. 320-4.
- Laine L, Kivitz AJ, Bello AE, Grahn AY, Schiff MH, Taha AS. Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers. The American Journal Of Gastroenterology 2011, 107: ajg2011443. PMID: 22186979, PMCID: PMC3321505, DOI: 10.1038/ajg.2011.443.
- Ruff CT, Morrow DA, Jarolim P, Ren F, Contant CF, Kaur A, Curtis SP, Laine L, Cannon CP, Brune K. Evaluation of NT-proBNP and high sensitivity C-reactive protein for predicting cardiovascular risk in patients with arthritis taking longterm nonsteroidal antiinflammatory drugs. The Journal Of Rheumatology 2011, 38: 1071-8. PMID: 21459935, DOI: 10.3899/jrheum.100880.
- Laine L. Proton Pump Inhibitor Co-therapy With Clopidogrel: Is There GI Benefit or Cardiovascular Harm? Gastroenterology 2011, 140: 769-772.e2. PMID: 21266209, DOI: 10.1053/j.gastro.2011.01.024.
- Documents A, Abraham N, Hlatky M, Antman E, Bhatt D, Bjorkman D, Clark C, Furberg C, Johnson D, Kahi C, Laine L, Mahaffey K, Quigley E, Scheiman J, Sperling L, Tomaselli G. ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. Journal Of The American College Of Cardiology 2010, 56: 2051-2066. PMID: 21126648, DOI: 10.1016/j.jacc.2010.09.010.
- Abraham NS, Hlatky MA, Antman EM, Bhatt DL, Bjorkman DJ, Clark CB, Furberg CD, Johnson DA, Kahi CJ, Laine L, Mahaffey KW, Quigley EM, Scheiman J, Sperling LS, Tomaselli GF. ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. The American Journal Of Gastroenterology 2010, 105: 2533. PMID: 21131924, DOI: 10.1038/ajg.2010.445.
- Laine L, Katz PO, Johnson DA, Ibegbu I, Goldstein MJ, Chou C, Rossiter G, Lu Y. Randomised clinical trial: a novel rabeprazole extended release 50 mg formulation vs. esomeprazole 40 mg in healing of moderate‐to‐severe erosive oesophagitis – the results of two double‐blind studies. Alimentary Pharmacology & Therapeutics 2010, 33: 203-212. PMID: 21114792, DOI: 10.1111/j.1365-2036.2010.04516.x.
- Laine L, Abid S, Albillos A, Kamath P, Vinel J, García‐Pagán J. Treatment of Acute Bleeding. 2010, 101-118. DOI: 10.1002/9781444393989.ch10.
- Members W, Abraham N, Hlatky M, Antman E, Bhatt D, Bjorkman D, Clark C, Furberg C, Johnson D, Kahi C, Laine L, Mahaffey K, Quigley E, Scheiman J, Sperling L, Tomaselli G. ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. Circulation 2010, 122: 2619-2633. PMID: 21060077, DOI: 10.1161/cir.0b013e318202f701.
- Bhatt DL, Cryer BL, Contant CF, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Scirica BM, Murphy SA, Cannon CP. Clopidogrel with or without Omeprazole in Coronary Artery Disease. New England Journal Of Medicine 2010, 363: 1909-1917. PMID: 20925534, DOI: 10.1056/nejmoa1007964.
- Laine L, Curtis SP, Cryer B, Kaur A, Cannon CP. Risk factors for NSAID‐associated upper GI clinical events in a long‐term prospective study of 34 701 arthritis patients. Alimentary Pharmacology & Therapeutics 2010, 32: 1240-1248. PMID: 20955443, DOI: 10.1111/j.1365-2036.2010.04465.x.
- Laine L, Shah A. Randomized Trial of Urgent vs. Elective Colonoscopy in Patients Hospitalized With Lower GI Bleeding. The American Journal Of Gastroenterology 2010, 105: 2636. PMID: 20648004, DOI: 10.1038/ajg.2010.277.
- Laine L. Primary prophylaxis of esophageal variceal bleeding: An endoscopic approach. Journal Of Hepatology 2010, 52: 944-945. PMID: 20381891, DOI: 10.1016/j.jhep.2009.12.035.
- Laine L, Sahota A, Shah A. Does Capsule Endoscopy Improve Outcomes in Obscure Gastrointestinal Bleeding? Randomized Trial Versus Dedicated Small Bowel Radiography. Gastroenterology 2010, 138: 1673-1680.e1. PMID: 20138043, DOI: 10.1053/j.gastro.2010.01.047.
- Kim JJ, Simpson N, Klipfel N, DeBose R, Barr N, Laine L. Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease. Digestive Diseases And Sciences 2010, 55: 1059-1065. PMID: 20112061, DOI: 10.1007/s10620-010-1126-4.
- Laine L, Spiegel B, Rostom A, Moayyedi P, Kuipers EJ, Bardou M, Sung J, Barkun AN. Methodology for Randomized Trials of Patients With Nonvariceal Upper Gastrointestinal Bleeding: Recommendations From an International Consensus Conference. The American Journal Of Gastroenterology 2009, 105: ajg2009702. PMID: 20029415, DOI: 10.1038/ajg.2009.702.
- Laine L, Hennekens C. Proton Pump Inhibitor and Clopidogrel Interaction: Fact or Fiction? The American Journal Of Gastroenterology 2009, 105: ajg2009638. PMID: 19904241, DOI: 10.1038/ajg.2009.638.
- LAINE L, CONNORS L, GRIFFIN MR, CURTIS SP, KAUR A, CANNON CP. Prescription rates of protective co‐therapy for NSAID users at high GI risk and results of attempts to improve adherence to guidelines. Alimentary Pharmacology & Therapeutics 2009, 30: 767-774. PMID: 19594486, DOI: 10.1111/j.1365-2036.2009.04090.x.
- Krum H, Curtis SP, Kaur A, Wang H, Smugar SS, Weir MR, Laine L, Brater DC, Cannon CP. Baseline factors associated with congestive heart failure in patients receiving etoricoxib or diclofenac: multivariate analysis of the MEDAL program. European Journal Of Heart Failure 2009, 11: 542-550. PMID: 19380329, DOI: 10.1093/eurjhf/hfp054.
- Saliminejad M, Bemanian S, Chen J, Laine L. Yield and Cost of Colonoscopy in Patients with Metastatic Cancer of Unknown Primary. Gastrointestinal Endoscopy 2009, 69: ab277. DOI: 10.1016/j.gie.2009.03.743.
- Laine L, Sahota A, Shah A. Does Capsule Endoscopy Improve Outcomes in Obscure GI Bleeding: Randomized Controlled Trial of Capsule Endoscopy vs. Dedicated Small Bowel Radiography. Gastrointestinal Endoscopy 2009, 69: ab99. DOI: 10.1016/j.gie.2009.03.042.
- Krum H, Swergold G, Curtis SP, Kaur A, Wang H, Smugar SS, Weir MR, Laine L, Brater DC, Cannon CP. Factors associated with blood pressure changes in patients receiving diclofenac or etoricoxib: results from the MEDAL study. Journal Of Hypertension 2009, 27: 886-893. PMID: 19516186, DOI: 10.1097/hjh.0b013e328325d831.
- Laine L. Proton Pump Inhibitors and Bone Fractures? The American Journal Of Gastroenterology 2009, 104: ajg200948. PMID: 19262543, DOI: 10.1038/ajg.2009.48.
- Combe B, Swergold G, McLay J, McCarthy T, Zerbini C, Emery P, Connors L, Kaur A, Curtis S, Laine L, Cannon CP. Cardiovascular safety and gastrointestinal tolerability of etoricoxib vs diclofenac in a randomized controlled clinical trial (The MEDAL study). Rheumatology 2009, 48: 425-432. PMID: 19223284, DOI: 10.1093/rheumatology/kep005.
- Laine L, Goldkind L, Curtis SP, Connors LG, Yanqiong Z, Cannon CP. How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial. The American Journal Of Gastroenterology 2009, 104: ajg2008149. PMID: 19174782, DOI: 10.1038/ajg.2008.149.
- Sharma P, Chey W, Hunt R, Laine L, Malfertheiner P, Wani S. Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective. Diseases Of The Esophagus 2009, 22: 461-466. PMID: 19191851, DOI: 10.1111/j.1442-2050.2008.00934.x.
- SPIEGEL BM, FARID M, VAN OIJEN MG, LAINE L, HOWDEN CW, ESRAILIAN E. Adherence to best practice guidelines in dyspepsia: a survey comparing dyspepsia experts, community gastroenterologists and primary‐care providers. Alimentary Pharmacology & Therapeutics 2009, 29: 871-881. PMID: 19183152, PMCID: PMC2953468, DOI: 10.1111/j.1365-2036.2009.03935.x.
- Palta R, Sahota A, Bemarki A, Salama P, Simpson N, Laine L. Foreign-body ingestion: characteristics and outcomes in a lower socioeconomic population with predominantly intentional ingestion. Gastrointestinal Endoscopy 2008, 69: 426-433. PMID: 19019363, DOI: 10.1016/j.gie.2008.05.072.
- ESRAILIAN E, GRALNEK IM, JENSEN D, LAINE L, DULAI GS, EISEN G, SPIEGEL BM. Evaluating the process of care in nonvariceal upper gastrointestinal haemorrhage: a survey of expert vs. non‐expert gastroenterologists. Alimentary Pharmacology & Therapeutics 2008, 28: 1199-1208. PMID: 18729846, DOI: 10.1111/j.1365-2036.2008.03838.x.
- Chan FK, Abraham NS, Scheiman JM, Laine L. Management of Patients on Nonsteroidal Anti-inflammatory Drugs: A Clinical Practice Recommendation From the First International Working Party on Gastrointestinal and Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs and Anti-platelet Agents. The American Journal Of Gastroenterology 2008, 103: ajg2008576. PMID: 18853980, DOI: 10.1111/j.1572-0241.2008.02200.x.
- Zhao Y, Ma Y, Vikas P, Laine L. Macroscopic Colitis in Microscopic Colitis. The American Journal Of Gastroenterology 2008, 103: s183. DOI: 10.14309/00000434-200809001-00476.
- Laine L, McQuaid KR. Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials. Clinical Gastroenterology And Hepatology 2008, 7: 33-47. PMID: 18986845, DOI: 10.1016/j.cgh.2008.08.016.
- Elmunzer BJ, Young SD, Inadomi JM, Schoenfeld P, Laine L. Systematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers. The American Journal Of Gastroenterology 2008, 103: ajg2008521. PMID: 18684171, DOI: 10.1111/j.1572-0241.2008.02070.x.
- Laine L, Curtis SP, Langman M, Jensen DM, Cryer B, Kaur A, Cannon CP. Lower Gastrointestinal Events in a Double-Blind Trial of the Cyclo-Oxygenase-2 Selective Inhibitor Etoricoxib and the Traditional Nonsteroidal Anti-Inflammatory Drug Diclofenac. Gastroenterology 2008, 135: 1517-1525. PMID: 18823986, DOI: 10.1053/j.gastro.2008.07.067.
- Laine L, Takeuchi K, Tarnawski A. Gastric Mucosal Defense and Cytoprotection: Bench to Bedside. Gastroenterology 2008, 135: 41-60. PMID: 18549814, DOI: 10.1053/j.gastro.2008.05.030.
- Vakil N, Laine L, Talley NJ, Zakko SF, Tack J, Chey WD, Kralstein J, Earnest DL, Ligozio G, Cohard-Radice M. Tegaserod Treatment for Dysmotility-Like Functional Dyspepsia: Results of Two Randomized, Controlled Trials. The American Journal Of Gastroenterology 2008, 103: ajg2008383. PMID: 18616658, DOI: 10.1111/j.1572-0241.2008.01953.x.
- McQuaid KR, Laine L. A systematic review and meta-analysis of randomized, controlled trials of moderate sedation for routine endoscopic procedures. Gastrointestinal Endoscopy 2008, 67: 910-923. PMID: 18440381, DOI: 10.1016/j.gie.2007.12.046.
- de Franchis R, Eisen GM, Laine L, Fernandez‐Urien I, Herrerias JM, Brown RD, Fisher L, Vargas HE, Vargo J, Thompson J, Eliakim R. Esophageal capsule endoscopy for screening and surveillance of esophageal varices in patients with portal hypertension. Hepatology 2008, 47: 1595-1603. PMID: 18435461, DOI: 10.1002/hep.22227.
- Laine L, Shah A, Bemanian S. Intragastric pH With Oral vs Intravenous Bolus Plus Infusion Proton-Pump Inhibitor Therapy in Patients With Bleeding Ulcers. Gastroenterology 2008, 134: 1836-1841. PMID: 18423628, DOI: 10.1053/j.gastro.2008.03.006.
- Laine L, Long GL, Bakos GJ, Vakharia OJ, Cunningham C. Optimizing bipolar electrocoagulation for endoscopic hemostasis: assessment of factors influencing energy delivery and coagulation. Gastrointestinal Endoscopy 2008, 67: 502-508. PMID: 18294513, DOI: 10.1016/j.gie.2007.09.025.
- Laine L, White WB, Rostom A, Hochberg M. COX-2 Selective Inhibitors in the Treatment of Osteoarthritis. Seminars In Arthritis And Rheumatism 2008, 38: 165-187. PMID: 18177922, DOI: 10.1016/j.semarthrit.2007.10.004.
- Gastroinestinal BleedingLaine L. Gastroinestinal Bleeding in Harrison’s Principles of Internal Medicine, 17th Edition. Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, Eds. The McGraw-Hill Companies, Inc. 2008; pp. 257-60.
- Schreiner GC, Laine L, Murphy SA, Cannon CP. Evaluation of Proton Pump Inhibitor Use in Patients With Acute Coronary Syndromes Based on Risk Factors for Gastrointestinal Bleed. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2007, 6: 169-172. PMID: 18091407, DOI: 10.1097/hpc.0b013e318159921e.
- Fried M, Quigley E, Hunt R, Guyatt G, Anderson B, Bjorkman D, Farthing M, Fedail S, Green-Thompson R, Hampton J, Krabshuis J, Laine L, Horton R. Is an evidence-based approach to creating guidelines always the right one? Nature Reviews Gastroenterology & Hepatology 2007, 5: 60-61. PMID: 17998924, DOI: 10.1038/ncpgasthep0997.
- Fried M, Quigley E, Hunt R, Guyatt G, Anderson B, Bjorkman D, Farthing M, Fedail S, Green-Thompson R, Hampton J, Krabshuis J, Laine L, Horton R. Can global guidelines change health policy? Nature Reviews Gastroenterology & Hepatology 2007, 5: 120-121. PMID: 17998923, DOI: 10.1038/ncpgasthep0998.
- Fried M, Quigley E, Hunt R, Guyatt G, Anderson B, Bjorkman D, Farthing M, Fedail S, Green-Thompson R, Hampton J, Krabshuis J, Laine L, Horton R. Are global guidelines desirable, feasible and necessary? Nature Reviews Gastroenterology & Hepatology 2007, 5: 2-3. PMID: 17998926, DOI: 10.1038/ncpgasthep0994.
- Laine L, Curtis SP, Cryer B, Kaur A, Cannon CP, Committee F. Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. The Lancet 2007, 369: 465-473. PMID: 17292766, DOI: 10.1016/s0140-6736(07)60234-7.
- Laine L. Upper gastrointestinal bleeding. Clinical Update 2007, 14: 1-4. DOI: 10.1016/j.clinup.2006.12.001.
- McQuaid K, Laine L. Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials. American Journal Of Ophthalmology 2007, 143: 194. DOI: 10.1016/j.ajo.2006.11.002.
- Cannon CP, Curtis SP, FitzGerald GA, Krum H, Kaur A, Bolognese JA, Reicin AS, Bombardier C, Weinblatt ME, van der Heijde D, Erdmann E, Laine L, Committee F. Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. The Lancet 2006, 368: 1771-1781. PMID: 17113426, DOI: 10.1016/s0140-6736(06)69666-9.
- LAINE L. Review article: gastrointestinal bleeding with low‐dose aspirin – what's the risk? Alimentary Pharmacology & Therapeutics 2006, 24: 897-908. PMID: 16948802, DOI: 10.1111/j.1365-2036.2006.03077.x.
- LAINE L, SMITH R, MIN K, CHEN C, DUBOIS RW. Systematic review: the lower gastrointestinal adverse effects of non‐steroidal anti‐inflammatory drugs. Alimentary Pharmacology & Therapeutics 2006, 24: 751-767. PMID: 16918879, DOI: 10.1111/j.1365-2036.2006.03043.x.
- Laine L. The gastroenterology boards. Gastrointestinal Endoscopy 2006, 64: 246-247. DOI: 10.1016/j.gie.2006.04.021.
- Bolognese J, Cannon C, Curtis S, Laine L. THE MEDAL PROGRAM DESIGN: THREE RANDOMIZED TRIALS IN 34,701 PATIENTS WITH OA OR RA TO EVALUATE CARDIOVASCULAR SAFETY OF ETORICOXIB VERSUS DICLOFENAC. JCR Journal Of Clinical Rheumatology 2006, 12: s85-s86. DOI: 10.1097/01.rhu.0000233330.39079.13.
- McQuaid KR, Laine L. Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials. The American Journal Of Medicine 2006, 119: 624-638. PMID: 16887404, DOI: 10.1016/j.amjmed.2005.10.039.
- Cannon CP, Curtis SP, Bolognese JA, Laine L, Committee F. Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) Study Program: Cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis. American Heart Journal 2006, 152: 237-245. PMID: 16875903, DOI: 10.1016/j.ahj.2006.05.024.
- PAIS SA, NATHWANI RA, DHAR V, NOWAIN A, LAINE L. Effect of frequent dosing of an oral proton pump inhibitor on intragastric pH. Alimentary Pharmacology & Therapeutics 2006, 23: 1607-1613. PMID: 16696810, DOI: 10.1111/j.1365-2036.2006.02933.x.
- Laine L. GI Risk and Risk Factors of NSAIDs. Journal Of Cardiovascular Pharmacology 2006, 47: s60-s66. PMID: 16785831, DOI: 10.1097/00005344-200605001-00011.
- Sahota A, Shandil R, Barmaki A, Salama P, Simpson N, Laine L. Foreign Body Ingestions: Characteristics and Outcomes in a Lower Socioeconomic Population. Gastrointestinal Endoscopy 2006, 63: ab154. DOI: 10.1016/j.gie.2006.03.296.
- Goldkind L, Laine L. A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience. Pharmacoepidemiology And Drug Safety 2006, 15: 213-220. PMID: 16456879, DOI: 10.1002/pds.1207.
- Laine L, Planas R, Nevens F, Bañares R, Patch D, Bosch J. Session 5: Treatment of the Acute Bleeding Episode. 2006, 217-242. DOI: 10.1002/9780470988831.ch9.
- Nathwani RA, Suh J, Simpson N, Shaposhnikov R, Chang A, Laine L. Foreign body “bezoar”. Gastrointestinal Endoscopy 2006, 63: 150. PMID: 16377334, DOI: 10.1016/j.gie.2005.04.009.
- Laine LA, Nathwani RA, Naritoku W. The effect of GI bleeding on Helicobacter pylori diagnostic testing: a prospective study at the time of bleeding and 1 month later. Gastrointestinal Endoscopy 2005, 62: 853-859. PMID: 16301025, DOI: 10.1016/j.gie.2005.09.019.
- Rao S, Ozturk R, Laine L. Clinical Utility of Diagnostic Tests for Constipation in Adults: A Systematic Review. The American Journal Of Gastroenterology 2005, 100: ajg2005283. PMID: 15984989, DOI: 10.1111/j.1572-0241.2005.41845.x.
- McQuaid KR, Laine L. Early Heartburn Relief With Proton Pump Inhibitors: A Systematic Review and Meta-analysis of Clinical Trials. Clinical Gastroenterology And Hepatology 2005, 3: 553-563. PMID: 15952097, DOI: 10.1016/s1542-3565(05)00023-6.
- Rostom A, Goldkind L, Laine L. Nonsteroidal Anti-Inflammatory Drugs and Hepatic Toxicity: A Systematic Review of Randomized Controlled Trials in Arthritis Patients. Clinical Gastroenterology And Hepatology 2005, 3: 489-498. PMID: 15880319, DOI: 10.1016/s1542-3565(04)00777-3.
- Conrad SA, Gabrielli A, Margolis B, Quartin A, Hata JS, Frank WO, Bagin RG, Rock JA, Hepburn B, Laine L. Randomized, double-blind comparison of immediate-release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal bleeding in critically ill patients. Critical Care Medicine 2005, 33: 760-765. PMID: 15818102, DOI: 10.1097/01.ccm.0000157751.92249.32.
- Gastroinestinal BleedingLaine L. Gastrointestinal Bleeding. In Harrison’s Principles of Internal Medicine, 16th Edition. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, Eds. The McGraw-Hill Companies, Inc. 2005; pp. 235-8.
- Laine L, Maller ES, Yu C, Quan H, Simon T. Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: A double-blind trial. Gastroenterology 2004, 127: 395-402. PMID: 15300570, DOI: 10.1053/j.gastro.2004.05.001.
- Rubenstein JH, Laine L. The hepatotoxicity of non‐steroidal anti‐inflammatory drugs. Alimentary Pharmacology & Therapeutics 2004, 20: 373-380. PMID: 15298630, DOI: 10.1111/j.1365-2036.2004.02092.x.
- Laine L. Treatment of Nonvariceal Upper GI Hemorrhage: What's Happening in the Real World. The American Journal Of Gastroenterology 2004, 99: ajg2004246. PMID: 15233661, DOI: 10.1111/j.1572-0241.2004.40252.x.
- Ofman JJ, Badamgarav E, Henning JM, Knight K, Laine L. Utilization of nonsteroidal anti-inflammatory drugs and antisecretory agents: a managed care claims analysis. The American Journal Of Medicine 2004, 116: 835-842. PMID: 15178499, DOI: 10.1016/j.amjmed.2004.02.028.
- Higgins PD, Davis KJ, Laine L. The epidemiology of ischaemic colitis. Alimentary Pharmacology & Therapeutics 2004, 19: 729-738. PMID: 15043513, DOI: 10.1111/j.1365-2036.2004.01903.x.
- Laine L. BLEEDING ULCERS WITH VISIBLE VESSELS OR CLOTS: IS IV PPI THERAPY ENOUGH? Evidence-Based Gastroenterology 2004, 5: 6-7. DOI: 10.1097/00132579-200402000-00003.
- Dubois RW, Melmed GY, Henning JM, Laine L. Guidelines for the appropriate use of non‐steroidal anti‐inflammatory drugs, cyclo‐oxygenase‐2‐specific inhibitors and proton pump inhibitors in patients requiring chronic anti‐inflammatory therapy. Alimentary Pharmacology & Therapeutics 2004, 19: 197-208. PMID: 14723611, DOI: 10.1111/j.0269-2813.2004.01834.x.
- Laine L. Proton pump inhibitor co-therapy with nonsteroidal anti-inflammatory drugs--nice or necessary? Gastroenterological Disorders 2004, 4 Suppl 4: s33-41. PMID: 15580145.
- Yang R, Zinn S, Maceri D, Laine L. Oro-pharyngeal biopsy: a new technique for gastroeternologists to evaluate patients with gastroesophageal reflux disease (GERD). The American Journal Of Gastroenterology 2003, 98: s293. DOI: 10.1111/j.1572-0241.2003.08620.x.
- Laine L. Coxibs were not cost-effective for arthritis pain in patients with average risk for ulcer complications. Annals Of Internal Medicine 2003, 139: 53. PMID: 12954045, DOI: 10.7326/acpjc-2003-139-2-053.
- Laine L, Wogen J, Yu H. Gastrointestinal health care resource utilization with chronic use of COX-2-specific inhibitors versus traditional NSAIDs1 1The Institute for Effectiveness Research, LLC, is a subsidiary of Medco Health Solutions, Inc., a Merck Company. Gastroenterology 2003, 125: 389-395. PMID: 12891540, DOI: 10.1016/s0016-5085(03)00900-4.
- Hawkey C, Laine L, Simon T, Quan H, Shingo S, Evans J. Incidence of gastroduodenal ulcers in patients with rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or placebo. European Journal Of Gastroenterology & Hepatology 2003, 15: 835. DOI: 10.1097/00042737-200307000-00021.
- Laine L. Celecoxib was as effective as diclofenac plus omeprazole in reducing recurrent ulcer bleeding in arthritis. Annals Of Internal Medicine 2003, 139: 12. PMID: 12841716, DOI: 10.7326/acpjc-2003-139-1-012.
- Hawkey CJ, Laine L, Simon T, Quan H, Shingo S, Evans J. Incidence of gastroduodenal ulcers in patients with rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or placebo: a multicentre, randomised, double blind study. Gut 2003, 52: 820. PMID: 12740337, PMCID: PMC1773685, DOI: 10.1136/gut.52.6.820.
- Laine L. Evidence-based medicine: clinical judgment is required. Gastroenterology 2003, 124: 1726. PMID: 12806603, DOI: 10.1016/s0016-5085(03)00546-8.
- Ofman J, Knight K, Badamgarav E, Henning J, Wallace K, Wong J, Dylan M, Laine L. Proton pump inhibitor use in patients with indications for low-dose aspirin who start COX-2 selective inhibitors or nonselective NSAIDs. Gastroenterology 2003, 124: a107. DOI: 10.1016/s0016-5085(03)80529-2.
- Ofman J, Badamgarav E, Knight K, Henning J, Wallce K, Wong J, Dylan M, Laine L. Non-selective NSAIDs and COX-2 selective inhibitors: GI risk and use of proton pump inhibitor prophylaxis. Gastroenterology 2003, 124: a107. DOI: 10.1016/s0016-5085(03)80528-0.
- Laine L, Von Allmen H, Henderson S. GI healthcare resource use in 6009 patients switching from chronic NSAID to COX-2 specific inhibitor therapy and the effect of prior PPI use. Gastroenterology 2003, 124: a108. DOI: 10.1016/s0016-5085(03)80531-0.
- Laine L, Goldstein J, Fort J. Do NSAIDs induce esophagitis? The effect of non-specific NSAIDs and COX-2 specific inhibitors±low-dose aspirin in prospective, randomized, double-blind, placebo-controlled endoscopic trials. Gastroenterology 2003, 124: a511. DOI: 10.1016/s0016-5085(03)82586-6.
- Laine L, Hunt R, El-Zimaity H, Nguyen B, Osato M, Spénard J. Bismuth-Based Quadruple Therapy Using a Single Capsule of Bismuth Biskalcitrate, Metronidazole, and Tetracycline Given With Omeprazole Versus Omeprazole, Amoxicillin, and Clarithromycin for Eradication of Helicobacter pylori in Duodenal Ulcer Patients: A Prospective, Randomized, Multicenter, North American Trial. The American Journal Of Gastroenterology 2003, 98: ajg2003137. PMID: 12650788, DOI: 10.1111/j.1572-0241.2003.t01-1-07288.x.
- Laine L. Is it time for quadruple therapy to be first line? 2003, 347-351. DOI: 10.1007/978-94-017-1763-2_36.
- Laine L. Helicobacter pylori eradication does not benefit non-ulcer dyspepsia. 2003, 275-281. DOI: 10.1007/978-94-017-1763-2_28.
- Sugg J, Laine L. Effect of Helicobacter pylori eradication on development of erosive esophagitis and gastroesophageal reflux disease symptoms: a post hoc analysis of eight double blind prospective studies. The American Journal Of Gastroenterology 2002, 97: 2992. PMID: 12492181, DOI: 10.1111/j.1572-0241.2002.07116.x.
- Laine L, Bombardier C, Hawkey CJ, Davis B, Shapiro D, Brett C, Reicin A. Stratifying the risk of NSAID-related upper gastrointestinal clinical events: Results of a double-blind outcomes study in patients with rheumatoid arthritis. Gastroenterology 2002, 123: 1006-1012. PMID: 12360461, DOI: 10.1053/gast.2002.36013.
- Laine L. Management of ulcers with adherent clots. Gastroenterology 2002, 123: 632-636. PMID: 12145815, DOI: 10.1053/gast.2002.35133.
- Laine L, Dhir V. Helicobacter pylori eradication does not worsen quality of life related to reflux symptoms: a prospective trial. Alimentary Pharmacology & Therapeutics 2002, 16: 1143-1148. PMID: 12030957, DOI: 10.1046/j.1365-2036.2002.01267.x.
- Laine L, Fennerty M, Schoenfeld P. Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia. Annals Of Internal Medicine 2002, 136: 556. DOI: 10.7326/0003-4819-136-7-200204020-00019.
- Helicobacter pylori eradication does not benefit non-ulcer dyspepsia.Laine L. Helicobacter pylori eradication does not benefit non-ulcer dyspepsia. Helicobacter pylori: Basic Mechanisms to Clinical Cure 2002. Hunt RH, Tytgat GNJ, Eds. Kluwer Academic Publishers. 2002; pp.275-81.
- Is it time for quadruple therapy to be first line?Laine L. Is it time for quadruple therapy to be first line? Helicobacter pylori: Basic Mechanisms to Clinical Cure 2002. Hunt RH, Tytgat GNJ, Eds. Kluwer Academic Publishers. 2002; pp.347-51.
- Laine L, Estrada R. Randomized trial of normal saline solution injection versus bipolar electrocoagulation for treatment of patients with high-risk bleeding ulcers: Is local tamponade enough? Gastrointestinal Endoscopy 2002, 55: 6-10. PMID: 11756906, DOI: 10.1067/mge.2002.120390.
- Laine L. Omeprazole was better than H. pylori eradication for preventing recurrent GI bleeding in patients receiving naproxen. Annals Of Internal Medicine 2001, 135: 92. DOI: 10.7326/acpjc-2001-135-3-092.
- Laine L. Review: Octreotide reduces rebleeding more than does vasopressin or terlipressin in patients with esophageal varices. Annals Of Internal Medicine 2001, 135: 51. DOI: 10.7326/acpjc-2001-135-2-051.
- Laine L. Reply–potential gastrointestinal effects of longterm acid suppression with proton pump inhibitors. Alimentary Pharmacology & Therapeutics 2001, 15: 1085-1086. DOI: 10.1046/j.1365-2036.2001.0994b.x.
- Wallace J, Ofman J, Enkhe B, Chiou C, Henning J, Laine L. The cost-effectiveness of competing strategies for the preventionol recurrent ulcer-related hemorrhage. Gastroenterology 2001, 120: a403. DOI: 10.1016/s0016-5085(08)82004-5.
- Laine L, Hawkey C, Bombardier C, Shapiro D, Reicin A. Stratilying the risk of clinical upper Gl events in NSAID users: Results from a double-blind outcomes study. Gastroenterology 2001, 120: a105. DOI: 10.1016/s0016-5085(08)80513-6.
- Laine L, Hunt R, El-Zimaity H, Osato M, Spenard J, Pharma A. Morth American randomized trial of single-triple capsule (bismuth subcitrate, metronidazele, tetracycline) plus omeprazole vs. Omeprazole, amoxicillin, and clarithremycin for H. pylori eradication. Gastroenterology 2001, 120: a580. DOI: 10.1016/s0016-5085(08)82885-5.
- LAINE L, HAWKEY C, BOMBARDIER C, SHAPIRO D, REICIN A. Stratilying the risk of clinical upper Gl events in NSAID users: Results from a double-blind outcomes study. Gastroenterology 2001, 120: a105-a105. DOI: 10.1016/s0016-5085(01)80513-8.
- WALLACE J, OFMAN J, ENKHE B, CHIOU C, HENNING J, LAINE L. The cost-effectiveness of competing strategies for the preventionol recurrent ulcer-related hemorrhage. Gastroenterology 2001, 120: a403-a403. DOI: 10.1016/s0016-5085(01)82004-7.
- Laine L, Schoenfeld P, Fennerty M. Therapy for Helicobacter pylori in patients with nonulcer dyspepsia. A meta-analysis of randomized, controlled trials. Annals Of Internal Medicine 2001, 134: 361-9. PMID: 11242496, DOI: 10.7326/0003-4819-134-5-200103060-00008.
- Laine L. Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient. Gastroenterology 2001, 120: 594-606. PMID: 11179238, DOI: 10.1053/gast.2001.21907.
- Burroughs A, Bosch J, Garcia‐Tsao G, Henderson J, Laine L, Nevens F, Riggio O. Session 1 ‒ Definition of Key Events: Lets's Try Again. 2001, 13-21. DOI: 10.1002/9780470760154.ch2.
- Laine L, Burroughs A, Silvain C, Vinel J, Bosch J. Session 6 ‒ Treatment of the Acute Bleeding Episode. 2001, 134-169. DOI: 10.1002/9780470760154.ch10.
- Gastroinestinal BleedingLaine L. Gastrointestinal Bleeding. In Harrison’s Principles of Internal Medicine, 15th Edition. Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, Eds. The McGraw-Hill Companies, Inc. 2001; pp. 252-4.
- Laine L, Fennerty M, Osato M, Sugg J, Suchower L, Probst P, Levine J. Esomeprazole-based Helicobacter pylori eradication therapy and the effect of antibiotic resistance: results of three US multicenter, double-blind trials. The American Journal Of Gastroenterology 2000, 95: ajg20001583. PMID: 11151867, DOI: 10.1111/j.1572-0241.2000.03349.x.
- LAINE L. FOREWORD. Gastroenterology Clinics Of North America 2000, 29: 13-14. DOI: 10.1016/s0889-8553(05)70142-4.
- Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, Day R, Ferraz M, Hawkey C, Hochberg M, Kvien T, Schnitzer T. Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis. New England Journal Of Medicine 2000, 343: 1520-1528. PMID: 11087881, DOI: 10.1056/nejm200011233432103.
- LAINE L. FOREWORD. Gastroenterology Clinics Of North America 2000, 29: 11a. DOI: 10.1016/s0889-8553(05)70128-x.
- Laine L, Bombardier C, Reicin A, Hawkey C, Watson D, Ramey D, Brett C. Gastrointestinal (GI) co-therapy, procedures, and hospitalizations in a GI outcomes study of rofecoxib vs. naproxen in rheumatoid arthritis. The American Journal Of Gastroenterology 2000, 95: 2633. DOI: 10.1111/j.1572-0241.2000.03124.x.
- Laine L, Sugg J, Suchower L, Neil G. Endoscopic biopsy requirements for post-treatment diagnosis of Helicobacter pylori. Gastrointestinal Endoscopy 2000, 51: 664-669. PMID: 10840297, DOI: 10.1067/mge.2000.105776.
- Laine, Ahnen, Mcclain, Solcia, Walsh. Review article: potential gastrointestinal effects of long‐term acid suppression with proton pump inhibitors. Alimentary Pharmacology & Therapeutics 2000, 14: 651-668. PMID: 10848649, DOI: 10.1046/j.1365-2036.2000.00768.x.
- Balfe D, Ralls P, Bree R, DiSantis D, Glick S, Levine M, Megibow A, Saini S, Shuman W, Greene F, Laine L, Lillemoe K, Kidd R. Imaging strategies in the initial evaluation of the jaundiced patient. American College of Radiology. ACR Appropriateness Criteria. Radiology 2000, 215 Suppl: 125-33. PMID: 11037417.
- Laine L, Schoenfeld P, Fennerty M. H. pylori therapy is not effective for treatment of non-ulcer dyspepsia: Meta-analysis of randomized controlled trials. Gastroenterology 2000, 118: a440. DOI: 10.1016/s0016-5085(00)83874-3.
- Laine L, Fennerty M, Suchower L, Probst P, Osato M, Levine J. H. pylori antibiotic resistance, eradication, and emergent resistance in U.S. double-blind trials of esomeprazole, clarithromycin, and amoxicillin. Gastroenterology 2000, 118: a498. DOI: 10.1016/s0016-5085(00)84113-x.
- Laine L, Sugg J, Probst P, Malone T, Neil G. Prevalence of active duodenal ulcer in H. pylori-positive patients with past history of duodenal ulcer and relationship to symptoms. Gastroenterology 2000, 118: a1264. DOI: 10.1016/s0016-5085(00)80899-9.
- Fennerty M, Laine L, Sugg J, Zuckerman S, Levine J. Esomeprazole based triple therapy is more effective than dual therapy for eradication of H pylori. Gastroenterology 2000, 118: a495. DOI: 10.1016/s0016-5085(00)84102-5.
- Laine L, Bombardier C, Hawkey C, Shapiro D, Reicin A. Influence of H. pylori and other potential risk factors on clinical gi events in a double-blind outcome study of rofecoxib VS. Naproxen. Gastroenterology 2000, 118: a862. DOI: 10.1016/s0016-5085(00)85588-2.
- Yang R, Ng S, Nichol M, Laine L. A cost and performance evaluation of disposable and reusable biopsy forceps in GI endoscopy. Gastrointestinal Endoscopy 2000, 51: 266-270. PMID: 10699769, DOI: 10.1016/s0016-5107(00)70353-1.
- Laine L. Reply. Gastroenterology 2000, 118: 641. DOI: 10.1016/s0016-5085(00)70282-4.
- Hawkey C, Laine L, Simon T, Beaulieu A, Maldonado‐Cocco J, Acevedo E, Shahane A, Quan H, Bolognese J, Mortensen E. Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: A randomized, double‐blind, placebo‐controlled trial. Arthritis & Rheumatism 2000, 43: 370-377. PMID: 10693877, DOI: 10.1002/1529-0131(200002)43:2<370::aid-anr17>3.0.co;2-d.
- Helicobacter pylori and nonulcer dyspepsiaCohen H, Laine L. Helicobacter pylori and nonulcer dyspepsia. In Dyspepsia. Johnson DA, Katz PO, Castell DO, Eds. American College of Physicians. Philadelphia, PA. 2000; pp 63-77.
- How to explain outcome differences in dyspepsia studiesFennerty MB, Laine LA. How to explain outcome differences in dyspepsia studies. Helicobacter pylori: Basic Mechanisms to Clinical Cure 2000. Hunt RH, Tytgat GNJ, Eds. Kluwer Academic Publishers. 2000; pp. 421-5.
- Fennerty M, Laine L. How to explain outcome differences in dyspepsia studies. 2000, 421-425. DOI: 10.1007/978-94-011-3927-4_44.
- Faigel D, Vartan G, Knigge K, Laine L, Fennerty M, Margaret N, Marquis S. Fingerstick Helicobacter pylori antibody test: better than laboratory serological testing? The American Journal Of Gastroenterology 1999, 94: ajg1999810. PMID: 10606304, DOI: 10.1111/j.1572-0241.1999.01510.x.
- Schoenfeld, Kimmey, Scheiman, Bjorkman, Laine. Review article: nonsteroidal anti‐inflammatory drug‐associated gastrointestinal complications—guidelines for prevention and treatment. Alimentary Pharmacology & Therapeutics 1999, 13: 1273-1285. PMID: 10540041, DOI: 10.1046/j.1365-2036.1999.00617.x.
- Laine L, Harper S, Simon T, Bath R, Johanson J, Schwartz H, Stern S, Quan H, Bolognese J, Group F. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2–specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis. Gastroenterology 1999, 117: 776-783. PMID: 10500058, DOI: 10.1016/s0016-5085(99)70334-3.
- Laine L. Management of Acute Colonic Pseudo-Obstruction. New England Journal Of Medicine 1999, 341: 192-193. PMID: 10403858, DOI: 10.1056/nejm199907153410309.
- Cave DR, van Zanten S, Carter E, Halpern EF, Klein S, Prather C, Stolte M, Laine L. A multicentre evaluation of the laser assisted ratio analyser (LARA): a novel device for measurement of 13CO2 in the 13C‐urea breath test for the detection of Helicobacter pylori infection. Alimentary Pharmacology & Therapeutics 1999, 13: 747-752. PMID: 10383503, DOI: 10.1046/j.1365-2036.1999.00534.x.
- Schoenfeld* P, Guyatt‡ G, Hamilton§ F, Laine∥ L, Cook‡ D, Bjorkman¶ D, Morgan# D, Peterson** W, Group F. An evidence-based approach to gastroenterology diagnosis. Gastroenterology 1999, 116: 1230-1237. PMID: 10220515, DOI: 10.1016/s0016-5085(99)70026-0.
- Laine L, Estrada R, Trujillo M, Cheybani K, Yeramian P, Smith S, Neil G. Once-daily therapy for H. pylori infection: a randomized comparison of four regimens. The American Journal Of Gastroenterology 1999, 94: 962. PMID: 10201465, DOI: 10.1111/j.1572-0241.1999.995_r.x.
- Laine L, Cohen H. Helicobacter pylori: drowning in a pool of blood? Gastrointestinal Endoscopy 1999, 49: 398-402. PMID: 10049431, DOI: 10.1016/s0016-5107(99)70024-6.
- Acid Peptic DisordersDel Valle J, Cohen H, Laine L, Scheiman J. Acid Peptic Disorders. In Textbook of Gastroenterology, 3rd Edition. Yamada T, Alpers DH, Laine L, Owyang C, Powell D, Eds. Lippincott Williams & Wilkins. 1999; pp. 1370-1444.
- Laine L, Suchower L, Frantz J, Connors A, Neil G. Twice-daily, 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in duodenal ulcer disease: results of three multicenter, double-blind, United States trials. The American Journal Of Gastroenterology 1998, 93: ajg1998488. PMID: 9820381, DOI: 10.1111/j.1572-0241.1998.00602.x.
- Sadowski D, Cohen H, Laine L, Greenberg P, Goldstein J, Mihalov M, Cutler A. Evaluation of the FlexSure HP whole blood antibody test for diagnosis of Helicobacter pylori infection. The American Journal Of Gastroenterology 1998, 93: ajg1998490. PMID: 9820383, DOI: 10.1111/j.1572-0241.1998.00604.x.
- Bonacini M, Laine L. Esophageal Disease in Patients with AIDS: Diagnosis and Treatment. Gastrointestinal Endoscopy Clinics Of North America 1998, 8: 811-823. PMID: 9730933, DOI: 10.1016/s1052-5157(18)30233-2.
- Laine L, Estrada R, Trujillo M, Knigge K, Fennerty MB. Effect of proton-pump inhibitor therapy on diagnostic testing for Helicobacter pylori. Annals Of Internal Medicine 1998, 129: 547-50. PMID: 9758575, DOI: 10.7326/0003-4819-129-7-199810010-00007.
- Laine L, Hopkins R, Girardi L. Has the impact of helicobacter pylori therapy on ulcer recurrence in the united states been overstated? The American Journal Of Gastroenterology 1998, 93: 1409. PMID: 9732917, DOI: 10.1111/j.1572-0241.1998.452_a.x.
- Laine L. Has the impact of helicobacter pylori therapy on ulcer recurrence in the united states been overstated? A meta-analysis of rigorously designed trials. The American Journal Of Gastroenterology 1998, 93: 1409-1415. DOI: 10.1016/s0002-9270(98)00333-5.
- Schoenfeld P, Cook D, Hamilton F, Laine L, Morgan D, Peterson W, Group F. An evidence-based approach to gastroenterology therapy. Gastroenterology 1998, 114: 1318-1325. PMID: 9609770, DOI: 10.1016/s0016-5085(98)70439-1.
- Laine, Johnson, Suchower, Ronca, Hwang, Neil. US double‐blind, controlled trials of omeprazole and amoxycillin for treatment of Helicobacter pylori. Alimentary Pharmacology & Therapeutics 1998, 12: 377-382. PMID: 9690729, DOI: 10.1046/j.1365-2036.1998.00303.x.
- Chey W, Murthy U, Toskes P, Carpenter S, Laine L. Validation of the 13C-urea blood test for H. Pylori infection: A US, multicenter trial. Gastroenterology 1998, 114: a91. DOI: 10.1016/s0016-5085(98)80368-5.
- Laine L, Estrada R, Trujillo M, Cheybani K, Yeramian, Smith S, Nei G. Once-daily therapy for H. pylori: A randomized comparison of four regimens. Gastroenterology 1998, 114: a192-a193. DOI: 10.1016/s0016-5085(98)80784-1.
- Knigge K, Fennerty M, Faigel D, Magaret N, Marquis S, Vartan G, Laine L. An office-based whole blood test is preferable to a laboratory quantitative serology test in the determination of Helicobacter pylori infection documented by endoscopic biopsy. Gastroenterology 1998, 114: a180. DOI: 10.1016/s0016-5085(98)80731-2.
- Laine L, Suchower L, Connors A, Frantz J, Neil G. Twice-daily 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for H. Pylori eradication in duodenal ulcer disease: Results of 3 multicenter, double-blind, U.S. Trials. Gastroenterology 1998, 114: a193. DOI: 10.1016/s0016-5085(98)80787-7.
- Laine L, Suchower L, Connors A, Frantz J, Neil G. Reduced risk of clarithromycin-resistant H. pylori with amoxicillin cotherapy: Results from 3 multicenter double-blind U.S. trials. Gastroenterology 1998, 114: a193. DOI: 10.1016/s0016-5085(98)80786-5.
- Yang R, Hamamoto R, Laine L. 1-week Vs. 2-week bismuth subsalicylate-based triple therapy for H. Pylori: Results of a U.S. randomized trial. Gastroenterology 1998, 114: a340. DOI: 10.1016/s0016-5085(98)81378-4.
- Laine L, Estrada R, Trujillo M, Knigge C, Fennerty M. Prospective evaluation of the effect of proton pump inhibitor therapy on H. Pylori diagnostic testing. Gastroenterology 1998, 114: a193. DOI: 10.1016/s0016-5085(98)80785-3.
- Laine L, Fendrick A. Helicobacter pylori and peptic ulcer disease. Postgraduate Medicine 1998, 103: 231-243. PMID: 9519040, DOI: 10.3810/pgm.1998.03.423.
- Laine L, Suchower L, Johnson E, Ronca P, Neil G. Accuracy of CLOtest after Helicobacter pylori therapy. Gastrointestinal Endoscopy 1998, 47: 250-253. PMID: 9540877, DOI: 10.1016/s0016-5107(98)70321-9.
- Laine L, Sidhom O, Emami S, Estrada R, Cohen H. Effect of blood on rapid urease testing of gastric mucosal biopsy specimens. Gastrointestinal Endoscopy 1998, 47: 141-143. PMID: 9512278, DOI: 10.1016/s0016-5107(98)70346-3.
- Laine L. Management of actively bleeding esophageal varices. Gastrointestinal Endoscopy 1997, 46: 83-84. PMID: 9260714, DOI: 10.1016/s0016-5107(97)70218-9.
- Laine L, Lewin D, Naritoku W, Cohen H. Prospective comparison of H&E, Giemsa, and Genta stains for the diagnosis of Helicobacter pylori. Gastrointestinal Endoscopy 1997, 45: 463-467. PMID: 9199901, DOI: 10.1016/s0016-5107(97)70174-3.
- Crookes P, Leichman C, Leichman L, Tan M, Laine L, Stain S, Baranda J, Casagrande Y, Groshen S, Silberman H. Systemic chemotherapy for gastric carcinoma followed by postoperative intraperitoneal therapy. Cancer 1997, 79: 1767-1775. PMID: 9128994, DOI: 10.1002/(sici)1097-0142(19970501)79:9<1767::aid-cncr19>3.0.co;2-w.
- LAINE L. Introduction. Alimentary Pharmacology & Therapeutics 1997, 11: 1-1. DOI: 10.1046/j.1365-2036.11.s1.8.x.
- Laine L, Stein C, Estrada R. Randomized comparison of saline injection vs. Bipolar electrocoagulation (BPEC) for treatment of patients with high-risk bleeding ulcers. Gastrointestinal Endoscopy 1997, 45: ab94. DOI: 10.1016/s0016-5107(97)80281-7.
- Yang R, Ng S, Nichol M, Laine L. Disposable versus reusable biopsy forceps: A prospective cost and performance evaluation. Gastrointestinal Endoscopy 1997, 45: ab58. DOI: 10.1016/s0016-5107(97)80136-8.
- Gastroinestinal BleedingLaine L. Gastrointestinal bleeding. In Sleisenger and Fordtran’s Gastrointestinal Disease, 6th Edition. Feldman M, Scharschmidt B, Sleisenger MH, Eds. W.B. Saunders Co. 1997; pp. 198-219.
- Laine L, Lewin D, Naritoku W, Estrada R, Cohen H. Prospective comparison of commercially available rapid urease tests for the diagnosis of Helicobacter pylori. Gastrointestinal Endoscopy 1996, 44: 523-526. PMID: 8934155, DOI: 10.1016/s0016-5107(96)70002-0.
- Laine L, Estrada R, Lewin D, Cohen H. The influence of warming on rapid urease test results: a prospective evaluation. Gastrointestinal Endoscopy 1996, 44: 429-432. PMID: 8905363, DOI: 10.1016/s0016-5107(96)70094-9.
- Laine L. Nonsteroidal Anti-Inflammatory Drug Gastropathy. Gastrointestinal Endoscopy Clinics Of North America 1996, 6: 489-504. PMID: 8803564, DOI: 10.1016/s1052-5157(18)30351-9.
- Laine L. Helicobacter pylori and Complicated Ulcer Disease. The American Journal Of Medicine 1996, 100: 52s-59s. PMID: 8644783, DOI: 10.1016/s0002-9343(96)80229-4.
- Laine L. Octreotide after endoscopic variceal ligation reduced recurrent bleeding. Annals Of Internal Medicine 1996, 124: 66. DOI: 10.7326/acpjc-1996-124-3-066.
- Soll A, Achord J, Bozymski G, Brooks S, Lanza F, Lyon D, Meyer G, Reinus J, Schuster M, Achord J, Ofman J, Glassman P, Laine L, Tytgat G, Walsh J, Graham D, Peterson W. Medical Treatment of Peptic Ulcer Disease: Practice Guidelines. JAMA 1996, 275: 622-629. DOI: 10.1001/jama.1996.03530320046033.
- Laine L, Stein C, Sharma V. A prospective outcome study of patients with clot in an ulcer and the effect of irrigation. Gastrointestinal Endoscopy 1996, 43: 107-110. PMID: 8635701, DOI: 10.1016/s0016-5107(06)80109-4.
- Laine L, Stein C, Sharma V. Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices. Gastroenterology 1996, 110: 529-533. PMID: 8566601, DOI: 10.1053/gast.1996.v110.pm8566601.
- Laine L, Chun D, Stein C, El-Beblawi I, Sharma V, Chandrasoma P. The influence of size or number of biopsies on rapid urease test results: a prospective evaluation. Gastrointestinal Endoscopy 1996, 43: 49-53. PMID: 8903818, DOI: 10.1016/s0016-5107(96)70260-2.
- Laine L, Cohen H, Sloane R, Marin-Sorensen M, Weinstein W. Interobserver agreement and predictive value of endoscopic findings for H. pylori and gastritis in normal volunteers. Gastrointestinal Endoscopy 1995, 42: 420-423. PMID: 8566631, DOI: 10.1016/s0016-5107(95)70043-9.
- Laine L, Sloane R, Ferretti M, Cominelli F. A randomized, double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production. Gastrointestinal Endoscopy 1995, 42: 428-433. PMID: 8566633, DOI: 10.1016/s0016-5107(95)70045-5.
- Laine L, Cook D. Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis. Annals Of Internal Medicine 1995, 123: 280-7. PMID: 7611595, DOI: 10.7326/0003-4819-123-4-199508150-00007.
- Laine L. Ligation: Endoscopic treatment of choice for patients with bleeding esophageal varices? Hepatology 1995, 22: 663-665. PMID: 7635437, DOI: 10.1002/hep.1840220242.
- Laine L. Ligation: Endoscopic treatment of choice for patients with bleeding esophageal varices? Hepatology 1995, 22: 663-665. DOI: 10.1016/0270-9139(95)90594-4.
- Laine L, Chun D, Stein C, El-Beblawi I, Sharma V, Chandrasoma P. The influence of size or number of biopsies on rapid urease test results: A prospective evaluation. Gastroenterology 1995, 108: a142. DOI: 10.1016/0016-5085(95)23232-x.
- Yang R, Laine L. Randomized study of monopolar vs. bipolar polypectomy snares. Gastrointestinal Endoscopy 1995, 41: 315. DOI: 10.1016/s0016-5107(05)80116-6.
- Laine L, Stein C, Sharma V. Randomized comparison of ligation VS. Ligation plus sclerotherapy for esophageal variceal bleeding. Gastrointestinal Endoscopy 1995, 41: 353. DOI: 10.1016/s0016-5107(05)80268-8.
- Laine L, Stein C, Sharma V. A prospective outcome study of patients with clots in an ulcer and the effect of irrigation. Gastrointestinal Endoscopy 1995, 41: 368. DOI: 10.1016/s0016-5107(05)80325-6.
- Stein C, Laine L. Randomized comparison of normal saline injection vs. bipolar electrocoagulation in high-risk patients with bleeding ulcers. Gastrointestinal Endoscopy 1995, 41: 371. DOI: 10.1016/s0016-5107(05)80340-2.
- Yang R, Ha T, Roque J, Laine L. Randomized, prospective study of bipolar electrocoagulation (BPEC) vs. infrared coagulation (IRC) for bleeding internal hemorrhoids (IH). Gastrointestinal Endoscopy 1995, 41: 387. DOI: 10.1016/s0016-5107(05)80401-8.
- LAINE L, COMINELLI F, SLOANE R, CASINI‐RAGGI V, MARIN‐SORENSEN M, WEINSTEIN WM. Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: a controlled double‐blind trial. Alimentary Pharmacology & Therapeutics 1995, 9: 127-135. PMID: 7605852, DOI: 10.1111/j.1365-2036.1995.tb00361.x.
- Yang R, Laine L. Mucosal stripping: a complication of push enteroscopy. Gastrointestinal Endoscopy 1995, 41: 156-158. PMID: 7721006, DOI: 10.1016/s0016-5107(05)80601-7.
- Laine L. The long-term management of patients with bleeding ulcers: Helicobacter pylori eradication instead of maintenance antisecretory therapy. Gastrointestinal Endoscopy 1995, 41: 77-79. PMID: 7698632, DOI: 10.1016/s0016-5107(95)70283-0.
- Acid Peptic DisordersIsenberg J, McQuaid KR, Laine L, Walsh JH. Acid Peptic Disorders. In Textbook of Gastroenterology. Yamada T, Ed. J.B. Lippincott Co. 2nd Edition 1995;1347-1430.
- Yang R, Naritoku W, Laine L. Prospective, randomized comparison of disposable and reusable biopsy forceps in gastrointestinal endoscopy. Gastrointestinal Endoscopy 1994, 40: 671-674. PMID: 7859962, DOI: 10.1016/s0016-5107(94)70107-5.
- Laine L, Peterson W. Bleeding Peptic Ulcer. New England Journal Of Medicine 1994, 331: 717-727. PMID: 8058080, DOI: 10.1056/nejm199409153311107.
- Laine L. The natural history of esophageal candidiasis after successful treatment in patients with AIDS. Gastroenterology 1994, 107: 744-746. PMID: 8076760, DOI: 10.1016/0016-5085(94)90122-8.
- Laine L. Esophageal disease in human immunodeficiency virus infection. JAMA Internal Medicine 1994, 154: 1577-1582. DOI: 10.1001/archinte.154.14.1577.
- Laine L, Freeman M, Cohen H. Lack of uniformity in evaluation of endoscopic prognostic features of bleeding ulcers. Gastrointestinal Endoscopy 1994, 40: 411-417. PMID: 7926529, DOI: 10.1016/s0016-5107(94)70202-0.
- Techniques and results for control of gastrointestinal bleeding: bipolar/multi-polar electrocoagulation and heater probeLaine L. Techniques and results for control of gastrointestinal bleeding: bipolar/multi-polar electrocoagulation and heater probe. In: Barkin JS, O’Phelan CA (Eds). Advanced therapeutic endoscopy. 2nd Ed. New York: Raven Press 1994; pp. 119-23.
- Laine L, el-Newihi HM, Migikovsky B, Sloane R, Garcia F. Endoscopic ligation compared with sclerotherapy for the treatment of bleeding esophageal varices. Annals Of Internal Medicine 1993, 119: 1-7. PMID: 8498757, DOI: 10.7326/0003-4819-119-1-199307010-00001.
- Laine L, Garcia F, McGilligan K, Malinko A, Sinatra F, Thomas D. Protein-losing enteropathy and hypoalbuminemia in AIDS. AIDS 1993, 7: 837-840. PMID: 8363760, DOI: 10.1097/00002030-199306000-00012.
- Laine L. Cost-Effective Treatment of Candida Esophagitis. Annals Of Internal Medicine 1993, 118: 824-825. DOI: 10.7326/0003-4819-118-10-199305150-00016.
- Laine L. HELICOBACTER PYLORI, GASTRIC ULCER, AND AGENTS NOXIOUS TO THE GASTRIC MUCOSA. Gastroenterology Clinics Of North America 1993, 22: 117-125. PMID: 8449561, DOI: 10.1016/s0889-8553(21)00267-3.
- Laine L. Refining the prognostic value of endoscopy in patients presenting with bleeding ulcers. Gastrointestinal Endoscopy 1993, 39: 461-462. PMID: 8514088, DOI: 10.1016/s0016-5107(93)70132-7.
- Yang R, Migikovsky B, Peicher J, Laine L. Randomized, prospective trial of direct current versus bipolar electrocoagulation for bleeding internal hemorrhoids. Gastrointestinal Endoscopy 1993, 39: 766-769. PMID: 8293898, DOI: 10.1016/s0016-5107(93)70261-8.
- Gastrointestinal BleedingPeterson WL, Laine L. Gastrointestinal bleeding. In Gastrointestinal Disease, 5th Edition. Sleisenger MH, Fordtran JS, Ed. W.B. Saunders Company 1993; pp. 162-92.
- Laine L. Comment. Gastroenterology 1992, 103: 1980-1981. DOI: 10.1016/0016-5085(92)91462-d.
- Laine L, Dretler RH, Conteas CN, Tuazon C, Koster FM, Sattler F, Squires K, Islam MZ. Fluconazole compared with ketoconazole for the treatment of Candida esophagitis in AIDS. A randomized trial. Annals Of Internal Medicine 1992, 117: 655-60. PMID: 1308663, DOI: 10.7326/0003-4819-117-8-655.
- Laine L. A new double lumen, direct irrigation injection therapy catheter. Gastrointestinal Endoscopy 1992, 38: 594-595. PMID: 1397918, DOI: 10.1016/s0016-5107(92)70525-2.
- Laine L. Endoscopic injection reduced rebleeding in bleeding peptic ulcers. Annals Of Internal Medicine 1992, 117: 38. DOI: 10.7326/acpjc-1992-117-2-038.
- Laine L. Endoscopic injection reduced further bleeding and need for surgery in patients with bleeding duodenal ulcers. Annals Of Internal Medicine 1992, 117: 39. DOI: 10.7326/acpjc-1992-117-2-039.
- Cook D, Laine L. Indications, Technique, and Complications of Balloon Tamponade for Variceal Gastrointestinal Bleeding. Journal Of Intensive Care Medicine 1992, 7: 212-218. PMID: 10147943, DOI: 10.1177/088506669200700408.
- Cook D, Guyatt G, Salena B, Laine L. Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis. Gastroenterology 1992, 102: 139-148. PMID: 1530782, DOI: 10.1016/0016-5085(92)91793-4.
- Laine L, Cohen H, Brodhead J, Cantor D, Garcia F, Mosquera M. Prospective evaluation of immediate versus delayed refeeding and prognostic value of endoscopy in patients with upper gastrointestinal hemorrhage. Gastroenterology 1992, 102: 314-316. PMID: 1727765, DOI: 10.1016/0016-5085(92)91816-m.
- Acid Peptic DisordersMc Quaid KR, Laine L. Acid peptic disorders. In Atlas of Gastroenterology. Yamada T, (Ed.) J.B. Lippincott Company, 1992 pp. 164 -71.
- Endoscopic therapy of non-variceal bleeding: Bipolar/multipolar probe.Laine L. Endoscopic therapy of non-variceal bleeding: Bipolar/multipolar probe. In Gastrointestinal Bleeding. Schuman BM, Sugawa C, Lucas C, (Eds.) Igaku-Shoin Medical Publishers 1992 pp. 314-23.
- Laine L. Bipolar-Multipolar Electrocoagulation of Bleeding Ulcers. Gastrointestinal Endoscopy Clinics Of North America 1991, 1: 291-302. DOI: 10.1016/s1052-5157(18)30672-x.
- Bonacini M, Young T, Laine L. The Causes of Esophageal Symptoms in Human Immunodeficiency Virus Infection: A Prospective Study of 110 Patients. JAMA Internal Medicine 1991, 151: 1567-1572. DOI: 10.1001/archinte.1991.00400080067012.
- Bonacini M, Young T, Laine L. The causes of esophageal symptoms in human immunodeficiency virus infection. A prospective study of 110 patients. JAMA Internal Medicine 1991, 151: 1567-72. PMID: 1651690, DOI: 10.1001/archinte.151.8.1567.
- Cook D, Laine L, Guyatt G, Raffin T. Nosocomial Pneumonia and the Role of Gastric pH A Meta-Analysis. CHEST Journal 1991, 100: 7-13. PMID: 1676361, DOI: 10.1378/chest.100.1.7.
- Laine L. Determination of the optimal technique for bipolar electrocoagulation treatment An experimental evaluation of the BICAP and Gold probes. Gastroenterology 1991, 100: 107-112. PMID: 1983812, DOI: 10.1016/0016-5085(91)90589-d.
- Diseases of the stomach and duodenum: Helicobacter pylori, peptic ulcer diseases and gastritisIsenberg J, Mc Quaid KR, Laine L, Rubin W. Diseases of the stomach and duodenum: Helicobacter pylori, peptic ulcer diseases and gastritis. In Textbook of Gastroenterology. Yamada T, Ed. J.B. Lippincott Company. 1991 pp. 1241-98.
- Laine L. Multipolar electrocoagulation versus injection therapy in the treatment of bleeding peptic ulcers A prospective, randomized trial. Gastroenterology 1990, 99: 1303-1306. PMID: 2210238, DOI: 10.1016/0016-5085(90)91154-x.
- Silvain C, Fort E, Ingrand P, Beauchant M, Valenzuela J, Schubert T, Posillico J, Laine L. Acute variceal bleeding: Still searching for the right treatment. Hepatology 1990, 12: 625-626. PMID: 1976106, DOI: 10.1002/hep.1840120335.
- Laine L, Marin-Sorensen M, Weinstein W. Campylobacter pylori in alcoholic hemorrhagic “gastritis”. Digestive Diseases And Sciences 1989, 34: 677-680. PMID: 2785447, DOI: 10.1007/bf01540337.
- Laine L. Multipolar electrocoagulation in the treatment of peptic ulcers with nonbleeding visible vessels. A prospective, controlled trial. Annals Of Internal Medicine 1989, 110: 510-4. PMID: 2647014, DOI: 10.7326/0003-4819-110-7-510.
- Laine L. A prospective trial of an anti-splatter device for the protection of endoscopic personnel from potentially AIDS-infective fluids. Gastrointestinal Endoscopy 1988, 34: 470-471. PMID: 3234685, DOI: 10.1016/s0016-5107(88)71438-8.
- Pettross C, Appleman M, Cohen H, Valenzuela J, Chandrasoma P, Laine L. Prevalence ofCampylobacter pylori and association with antral mucosal histology in subjects with and without upper gastrointestinal symptoms. Digestive Diseases And Sciences 1988, 33: 649-653. PMID: 3371136, DOI: 10.1007/bf01540425.
- Laine L, Weinstein W. Histology of alcoholic hemorrhagic “gastritis”: A prospective evaluation. Gastroenterology 1988, 94: 1254-1262. PMID: 3258836, DOI: 10.1016/0016-5085(88)90661-0.
- Laine L, Weinstein W. Subepithelial hemorrhages and erosions of human stomach. Digestive Diseases And Sciences 1988, 33: 490-503. PMID: 3280275, DOI: 10.1007/bf01536037.
- Laine L, Bentley E, Chandrasoma P. Effect of oral iron therapy on the upper gastrointestinal tract. Digestive Diseases And Sciences 1988, 33: 172-177. PMID: 3257437, DOI: 10.1007/bf01535729.
- Laine L. Multipolar Electrocoagulation in the Treatment of Active Upper Gastrointestinal Tract Hemorrhage. New England Journal Of Medicine 1987, 316: 1613-1617. PMID: 3295547, DOI: 10.1056/nejm198706253162601.
- Laine L, Politoske EJ, Gill P. Protein-Losing Enteropathy in Acquired Immunodeficiency Syndrome due to Intestinal Kaposi's Sarcoma. JAMA Internal Medicine 1987, 147: 1174-1175. PMID: 3592885, DOI: 10.1001/archinte.1987.00370060170028.
- Laine L. Protein-losing enteropathy in acquired immunodeficiency syndrome due to intestinal Kaposi's sarcoma. JAMA Internal Medicine 1987, 147: 1174-1175. DOI: 10.1001/archinte.147.6.1174.
- Laine L, Holt K. Recurrent Pericarditis and Celiac Disease. JAMA 1984, 252: 3168-3168. PMID: 6502887, DOI: 10.1001/jama.1984.03350220074036.
- Laine L. Recurrent pericarditis and celiac disease. JAMA 1984, 252: 3168-3168. DOI: 10.1001/jama.252.22.3168.
Departments and Programs
Biography
Loren Laine, MD, is a gastroenterologist who specializes in digestive diseases, including stomach ulcers and gastrointestinal bleeding.
As a professor of medicine at the Yale School of Medicine, Dr. Laine is committed to advancing understanding and treatment of digestive disorders. His research interests include gastrointestinal bleeding, ulcers, and fecal microbiota transplantation.
Dr. Laine completed his medical training at UCLA School of Medicine, followed by a residency in medicine at UCLA and a fellowship in gastroenterology at UCSD. He is a past President of the American Gastroenterological Association.
Titles
- Professor of Medicine (Digestive Diseases)
- Chief, Section of Digestive Diseases, Internal Medicine
- Medical Chief, Digestive Health, Yale New Haven Health
Education & Training
- FellowshipUCSD (1984)
- ResidencyUCLA (1982)
- MDUCLA School of Medicine (1979)
Additional Information
Honors & Recognitions
- Elliot Weser Lectureship: University of Texas, San Antonio (2021)
- Howard Spiro Teaching Award: (2020)
- Julius Friedenwald Medal, American Gastroenterological Association: (2018)
- Watson Lectureship: Royal College of Physicians and Surgeons, Glasgow (2017)
- Sunder J. Mehta Memorial Lectureship: University of Colorado (2017)
- Howard Spiro Teaching Award: (2014)
- Frederick and Irene Stare Visiting Professorship: Harvard Medical School, Tufts Medical School, Newton-Wellesley Hospital (2013)
- Barbara Frank Visiting Professorship: Drexel University School of Medicine (2013)
- Fellow: Royal College of Physicians (London) (2013)
- Ken and Louise Rosenberg Visiting Professorship: Harvard Medical School, Brigham & Women's Hospital (2013)
Board Certifications
- AB of Internal Medicine, Gastroenterology (1985)
- AB of Internal Medicine, Internal Medicine (1982)
Professional Service
- American Gastroenterological Association (2021 - Present): Advisor
- Digestive Disease Week (2020 - 2026): Chair
- Journal of Clinical Gastroenterology (2014 - 2017): Editorial Board Member
- American Gastroenterological Association (2013 - 2014): Chair
- American Gastroenterological Association (2012 - 2013): President
- American Gastroenterological Association Council (2003 - 2006): Chair
- Clinical Gastroenterlogy and Hepatology (AGA) (2003 - 2006): Editorial Board Member
- Gastroenterology (AGA) (2002 - 2006): Associate Editor
- Evidence-Based Gastroenterology (2000 - 2009): Editorial Board Member
- American Journal of Gastroenterology (ACG) (1997 - 2004): Editorial Board Member
Publications
- Giuffrè M, You K, Pang Z, Kresevic S, Chung S, Chen R, Ko Y, Chan C, Saarinen T, Ajcevic M, Crocè L, Garcia-Tsao G, Gralnek I, Sung J, Barkun A, Laine L, Sekhon J, Stadie B, Shung D. Expert of Experts Verification and Alignment (EVAL) Framework for Large Language Models Safety in Gastroenterology. Npj Digital Medicine 2025, 8: 242. PMID: 40319106, PMCID: PMC12049514, DOI: 10.1038/s41746-025-01589-z.
- Samnani S, Forbes N, Barkun A, Laine L, Leontiadis G, Alali A, Armstrong D, Borgaonkar M, Carman N, Carroll M, Gralnek I, Hookey L, Ibrahim M, Lau J, Pittayanon R, Sey M, Haidry R, Yuan Y, Tse F. WHICH IS THE BEST ENDOSCOPIC HEMOSTATIC THERAPY FOR DIEULAFOY’S LESIONS? A SYSTEMATIC REVIEW AND META-ANALYSIS. Gastrointestinal Endoscopy 2025, 101: s674. DOI: 10.1016/j.gie.2025.03.1160.
- Minhas G, Bukhari A, Forbes N, Barkun A, Laine L, Leontiadis G, Alali A, Armstrong D, Borgaonkar M, Carman N, Carroll M, Gralnek I, Hookey L, Ibrahim M, Lau J, Pittayanon R, Sey M, Tse F. TOPICAL HEMOSTATIC AGENTS: A POTENTIAL BREAKTHROUGH IN MALIGNANCY-RELATED GI BLEEDING? A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. Gastrointestinal Endoscopy 2025, 101: s669-s670. DOI: 10.1016/j.gie.2025.03.1152.
- Spechler S, Kolb J, Dunbar K, Gyawali C, Bell R, Fass R, Katz P, Laine L, Lipham J, Schnoll-Sussman F, Souza R, Yadlapati R, Kahrilas P. American Foregut Society White Paper Report on the Use of Potassium-Competitive Acid Blockers in the Treatment of Gastroesophageal Reflux Disease. Foregut The Journal Of The American Foregut Society 2025 DOI: 10.1177/26345161251325874.
- Samnani S, Yuan Y, Leontiadis G, Barkun A, Laine L, Tse F. A96 WHICH IS THE BEST ENDOSCOPIC HEMOSTATIC THERAPY FOR DIEULAFOY’S LESIONS? A SYSTEMATIC REVIEW AND META-ANALYSIS. Journal Of The Canadian Association Of Gastroenterology 2025, 8: i37-i37. PMCID: PMC11807509, DOI: 10.1093/jcag/gwae059.096.
- Minhas G, Bukhari A, Yuan Y, Leontiadis G, Laine L, Barkun A, Tse F. A43 TOPICAL HEMOSTATIC AGENTS: A POTENTIAL BREAKTHROUGH IN MALIGNANCY-RELATED GI BLEEDING? A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. Journal Of The Canadian Association Of Gastroenterology 2025, 8: i17-i17. PMCID: PMC11807633, DOI: 10.1093/jcag/gwae059.043.
- Patel A, Laine L, Moayyedi P. Reply. Gastroenterology 2025, 168: 849-850. PMID: 39848603, DOI: 10.1053/j.gastro.2025.01.001.
- Chey W, Mégraud F, Laine L, Smith N, Leifke E, Hunt B, Howden C. Influence of patient characteristics on Helicobacter pylori eradication with Vonoprazan: A subgroup analysis of the pHalcon‐HP trial. JGH Open 2024, 8: e70044. PMID: 39554983, PMCID: PMC11567116, DOI: 10.1002/jgh3.70044.
- Antunes C, Ghosh G, Katz P, Yadlapati R, Leifke E, Harris T, Graham H, Laine L. S655 Vonoprazan Improves Nocturnal Gastroesophageal Reflux Symptoms in Non-Erosive Reflux Disease. The American Journal Of Gastroenterology 2024, 119: s452-s453. DOI: 10.14309/01.ajg.0001031988.74205.82.
- Zheng N, Keloth V, You K, Kats D, Li D, Deshpande O, Sachar H, Xu H, Laine L, Shung D. Detection of Gastrointestinal Bleeding With Large Language Models to Aid Quality Improvement and Appropriate Reimbursement. Gastroenterology 2024, 168: 111-120.e4. PMID: 39304088, DOI: 10.1053/j.gastro.2024.09.014.
- Patel A, Laine L, Moayyedi P, Wu J. AGA Clinical Practice Update on Integrating Potassium-Competitive Acid Blockers Into Clinical Practice: Expert Review. Gastroenterology 2024, 167: 1228-1238. PMID: 39269391, DOI: 10.1053/j.gastro.2024.06.038.
- Shung D, Chan C, You K, Nakamura S, Saarinen T, Zheng N, Simonov M, Li D, Tsay C, Kawamura Y, Shen M, Hsiao A, Sekhon J, Laine L. Validation of an Electronic Health Record–Based Machine Learning Model Compared With Clinical Risk Scores for Gastrointestinal Bleeding. Gastroenterology 2024, 167: 1198-1212. PMID: 38971198, PMCID: PMC11493512, DOI: 10.1053/j.gastro.2024.06.030.
- Shung D, Li D, You K, Hung K, Laine L, Hughes M. Adoption of a gastroenterology hospitalist model and the impact on inpatient endoscopic practice volume: a controlled interrupted time-series analysis. IGIE 2024, 3: 329-332.e2. DOI: 10.1016/j.igie.2024.04.008.
- Spechler S, Laine L, DeVault K, Nabulsi A, Hunt B, Katz P. Comparison of Los Angeles Grades of Erosive Esophagitis Scored by Local Investigators vs Central Adjudicators in a Clinical Trial. Clinical Gastroenterology And Hepatology 2024, 22: 2526-2528.e1. PMID: 38777170, DOI: 10.1016/j.cgh.2024.05.007.
- Laine L, Spechler S, Yadlapati R, Schnoll-Sussman F, Smith N, Leifke E, Harris T, Hunt B, Fass R, Katz P. Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial. Clinical Gastroenterology And Hepatology 2024, 22: 2211-2220.e10. PMID: 38750866, DOI: 10.1016/j.cgh.2024.05.004.
- Rajashekar N, Shin Y, Pu Y, Chung S, You K, Giuffre M, Chan C, Saarinen T, Hsiao A, Sekhon J, Wong A, Evans L, Kizilcec R, Laine L, Mccall T, Shung D. Human-Algorithmic Interaction Using a Large Language Model-Augmented Artificial Intelligence Clinical Decision Support System. 2024, 1-20. DOI: 10.1145/3613904.3642024.
- Rajashekar N, Chan C, Laine L, Shung D. Mo1066 LARGE LANGUAGE MODEL-BASED SIMULATED PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING FOR MEDICAL EDUCATION – A PILOT STUDY WITH EMPATHGPT. Gastroenterology 2024, 166: s-933. DOI: 10.1016/s0016-5085(24)02628-3.
- Giuffrè M, You K, Chung S, Kresevic S, Chan C, Saarinen T, Nakamura S, Laine L, Sung J, Garcia-Tsao G, Gralnek I, Barkun A, Sekhon J, Shung D. Su1979 GUTGPT: NOVEL LARGE LANGUAGE MODEL PIPELINE OUTPERFORMS OTHER LARGE LANGUAGE MODELS IN ACCURACY AND SIMILARITY TO INTERNATIONAL EXPERTS FOR GUIDELINE RECOMMENDED MANAGEMENT OF PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING. Gastroenterology 2024, 166: s-889-s-890. DOI: 10.1016/s0016-5085(24)02528-9.
- Chung S, Rajashekar N, Pu Y, Shin Y, Giuffrè M, Chan C, You K, Saarinen T, Hsiao A, Sekhon J, Wong A, Evans L, McCall T, Kizilcec R, Laine L, Shung D. 407 IMPACT OF ARTIFICIAL INTELLIGENCE SYSTEMS FOR UPPER GASTROINTESTINAL BLEEDING ON CLINICIAN TRUST AND LEARNING USING LARGE LANGUAGE MODELS: A RANDOMIZED PILOT SIMULATION STUDY. Gastroenterology 2024, 166: s-95-s-96. DOI: 10.1016/s0016-5085(24)00715-7.
- Rajashekar N, Chan C, Deutsch J, Laine L, Shung D. Tu1649 SIMULATING THE PATIENT-PRACTITIONER RELATIONSHIP IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH LARGE LANGUAGE MODELBASED TOOLS – A PROOF OF CONCEPT. Gastroenterology 2024, 166: s-1364. DOI: 10.1016/s0016-5085(24)03586-8.
- Zheng N, Keloth V, You K, Li D, Xu H, Laine L, Shung D. 1244 AUTOMATED IDENTIFICATION OF RECURRENT GASTROINTESTINAL BLEEDING USING ELECTRONIC HEALTH RECORDS AND LARGE LANGUAGE MODELS. Gastroenterology 2024, 166: s-292. DOI: 10.1016/s0016-5085(24)01152-1.
- Zheng N, Keloth V, You K, Li D, Xu H, Laine L, Shung D. 543 IDENTIFYING OVERT SIGNS OF ACUTE GASTROINTESTINAL BLEEDING IN THE ELECTRONIC HEALTH RECORD WITH LARGE LANGUAGE MODELS. Gastroenterology 2024, 166: s-124-s-125. DOI: 10.1016/s0016-5085(24)00776-5.
- Dupont J, Giuffrè M, Zhong J, You K, Laine L, Shung D. Tu2035 DEEP LEARNING TO CLASSIFY ENDOSCOPIC STIGMATA FOR PATIENTS WITH ACUTE UPPER GASTROINTESTINAL BLEEDING. Gastroenterology 2024, 166: s-1502. DOI: 10.1016/s0016-5085(24)03892-7.
- Spechler S, Laine L, Devault K, Smith N, Leifke E, Nabulsi A, Hunt B, Katz P. Mo1281 COMPARISON OF LOCAL INVESTIGATOR-REPORTED VS CENTRALLY ADJUDICATED LOS ANGELES GRADES OF EROSIVE ESOPHAGITIS IN PATIENTS SCREENED FOR PARTICIPATION IN A RANDOMIZED TRIAL. Gastroenterology 2024, 166: s-1011-s-1012. DOI: 10.1016/s0016-5085(24)02800-2.
- Dupont J, Giuffrè M, Zheng N, Laine L, Shung D. Tu1390 VALIDATION OF A MULTIMODAL MACHINE LEARNING MODEL FOR POST-ENDOSCOPIC RISK STRATIFICATION IN ACUTE UPPER GASTROINTESTINAL BLEEDING. Gastroenterology 2024, 166: s-1327-s-1328. DOI: 10.1016/s0016-5085(24)03494-2.
- Laine L, Spechler S, Yadlapati R, Schnoll-Sussman F, Smith N, Leifke E, Harris T, Hunt B, Fass R, Katz P. 864 VONOPRAZAN FOR THE TREATMENT OF HEARTBURN IN NON-EROSIVE REFLUX DISEASE: A RANDOMIZED TRIAL. Gastroenterology 2024, 166: s-198. DOI: 10.1016/s0016-5085(24)00949-1.
- Laine L, Barkun A, Leontiadis G. Letter to the Editor: Endoscopy for potential variceal bleeding within 12 hours—Not so fast! Hepatology 2024, 80: e15-e16. PMID: 38607699, DOI: 10.1097/hep.0000000000000876.
- Kurlander J, Laine L, Kim H, Roberts C, Saffar D, Myers A, Holleman R, Gao Y, Shank M, Nelson R, Forman J, Helfrich C, Krein S, Saini S, Yang Y. Impact of large scale, multicomponent intervention to reduce proton pump inhibitor overuse in integrated healthcare system: difference-in-difference study. The BMJ 2024, 385: e076484. PMID: 38604668, PMCID: PMC11007585, DOI: 10.1136/bmj-2023-076484.
- Shung D, Laine L. Review article: Upper gastrointestinal bleeding – review of current evidence and implications for management. Alimentary Pharmacology & Therapeutics 2024, 59: 1062-1081. PMID: 38517201, DOI: 10.1111/apt.17949.
- Nagula S, Parasa S, Laine L, Shah S. AGA Clinical Practice Update on High-Quality Upper Endoscopy: Expert Review. Clinical Gastroenterology And Hepatology 2024, 22: 933-943. PMID: 38385942, DOI: 10.1016/j.cgh.2023.10.034.
- Shung D, Laine L. Chapter 2 Data access, data bias, data equity. 2024, 13-26. DOI: 10.1016/b978-0-323-95068-8.00002-9.
- Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Clinical predictive value of renalase in post-ERCP pancreatitis. Gastrointestinal Endoscopy 2023, 99: 822-825.e1. PMID: 38103747, DOI: 10.1016/j.gie.2023.12.020.
- Shung D, Lin J, Laine L. Achieving Value by Risk Stratification With Machine Learning Model or Clinical Risk Score in Acute Upper Gastrointestinal Bleeding: A Cost Minimization Analysis. The American Journal Of Gastroenterology 2023, 119: 371-373. PMID: 37753930, PMCID: PMC10872988, DOI: 10.14309/ajg.0000000000002520.
- Laine L. Management of Bleeding Due to Small-Intestinal Angiodysplasias. New England Journal Of Medicine 2023, 389: 1718-1720. PMID: 37913510, DOI: 10.1056/nejme2310338.
- Restrepo D, Doshi R, Nawaz A, Chaar A, Kothari T, Laine L, Muniraj T. S11 Cholecystectomy Reduces the Odds of Inpatient Mortality in Patients With Acute Biliary Pancreatitis. The American Journal Of Gastroenterology 2023, 118: s9-s10. DOI: 10.14309/01.ajg.0000949684.33264.0a.
- Li D, Laine L, Shung D. Trends in Upper Gastrointestinal Bleeding in Patients on Primary Prevention Aspirin: A Nationwide Emergency Department Sample Analysis, 2016-2020. The American Journal Of Medicine 2023, 136: 1179-1186.e1. PMID: 37696350, PMCID: PMC10841721, DOI: 10.1016/j.amjmed.2023.08.010.
- Nawaz A, Chaar A, Rizwan R, Fetene J, Restrepo D, Alchirazi K, Abdulkarim D, Khalid F, Mathialagan K, Cheung M, Laine L, Muniraj T. Su1920 IMPACT OF OBESITY AND MORBID OBESITY ON OUTCOMES OF PATIENTS UNDERGOING ENDOSCOPIC PANCREATIC NECRESECTOMY. Gastroenterology 2023, 164: s-714. DOI: 10.1016/s0016-5085(23)02660-4.
- Nawaz A, Chaar A, Rizwan R, Restrepo D, Fetene J, Alchirazi K, Abdulkarim D, Khalid F, Doshi R, Mathialagan K, Hung K, Laine L, Muniraj T. Sa1420 FRAILTY IS ASSOCIATED WITH POOR OUTCOMES IN PATIENTS ADMITTED FOR ACUTE NECROTIZING PANCREATITIS. Gastroenterology 2023, 164: s-390. DOI: 10.1016/s0016-5085(23)01905-4.
- Chey W, Mégraud F, Laine L, Smith N, Leifke E, Hunt B, Howden C. Sa1373 HELICOBACTER PYLORI ERADICATION RATES WITH VONOPRAZAN: SUBGROUP ANALYSIS FROM THE PHASE 3 PHALCON HP TRIAL. Gastroenterology 2023, 164: s-378. DOI: 10.1016/s0016-5085(23)01877-2.
- Laine L, Hecht G. Presentation of the Julius M. Friedenwald Medal to Sheila E. Crowe, MD. Gastroenterology 2023, 164: 1324-1328. PMID: 37061896, DOI: 10.1053/j.gastro.2023.03.212.
- Wang M, Weiss F, Guo X, Kolodecik T, Bewersdorf J, Laine L, Lerch M, Desir G, Gorelick F. Plasma renalase levels are associated with the development of acute pancreatitis. Pancreatology 2023, 23: 158-162. PMID: 36697349, PMCID: PMC11847554, DOI: 10.1016/j.pan.2023.01.001.
- Li D, Ong S, Hughes M, Hung K, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2022, 57: 94-102. PMID: 36394111, DOI: 10.1111/apt.17278.
- Laine L, DeVault K, Katz P, Mitev S, Lowe J, Hunt B, Spechler S. Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial. Gastroenterology 2022, 164: 61-71. PMID: 36228734, DOI: 10.1053/j.gastro.2022.09.041.
- Rodriguez NJ, Zheng N, Mezzacappa C, Canavan M, Laine L, Shung D. Disparities in Access to Endoscopy for Patients With Upper Gastrointestinal Bleeding Presenting to Emergency Departments. Gastroenterology 2022, 164: 1044-1046.e4. PMID: 36228735, PMCID: PMC10083188, DOI: 10.1053/j.gastro.2022.10.001.
- Zheng NS, Tsay C, Laine L, Shung DL. Trends in characteristics, management, and outcomes of patients presenting with gastrointestinal bleeding to emergency departments in the United States from 2006 to 2019. Alimentary Pharmacology & Therapeutics 2022, 56: 1543-1555. PMID: 36173090, PMCID: PMC9669230, DOI: 10.1111/apt.17238.
- Laursen S, Stanley A, Laine L, de Muckadell O. Rebleeding in peptic ulcer bleeding – a nationwide cohort study of 19,537 patients. Scandinavian Journal Of Gastroenterology 2022, 57: 1423-1429. PMID: 35853234, DOI: 10.1080/00365521.2022.2098050.
- Kurlander JE, Barnes GD, Fisher A, Gonzalez JJ, Helminski D, Saini SD, Sengupta N, Yang YX, Scheiman J, Laine L. Association of Antisecretory Drugs with Upper Gastrointestinal Bleeding in Patients Using Oral Anticoagulants: A Systematic Review and Meta-Analysis. The American Journal Of Medicine 2022, 135: 1231-1243.e8. PMID: 35679879, PMCID: PMC10031639, DOI: 10.1016/j.amjmed.2022.05.031.
- Chey WD, Mégraud F, Laine L, López LJ, Hunt BJ, Howden CW. Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial. Gastroenterology 2022, 163: 608-619. PMID: 35679950, DOI: 10.1053/j.gastro.2022.05.055.
- Tham JE, Lynch L, Laursen SB, Laine L, Dalton HR, Ngu J, Redondo-Cerezo E, Schultz M, Murray I, Michell N, Morris AJ, Nielsen MM, Stanley AJ. International multicenter study comparing demographics, therapy and outcomes in bleeding from Mallory Weiss tears and peptic ulcers. Endoscopy International Open 2022, 10: e653-e658. PMID: 35571482, PMCID: PMC9106442, DOI: 10.1055/a-1784-0655.
- Abraham NS, Barkun AN, Sauer BG, Douketis J, Laine L, Noseworthy PA, Telford JJ, Leontiadis GI. American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period. The American Journal Of Gastroenterology 2022, 117: 542-558. PMID: 35297395, PMCID: PMC8966740, DOI: 10.14309/ajg.0000000000001627.
- Abraham NS, Barkun AN, Sauer BG, Douketis J, Laine L, Noseworthy PA, Telford JJ, Leontiadis GI. American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period. Journal Of The Canadian Association Of Gastroenterology 2022, 5: 100-101. PMID: 35368325, PMCID: PMC8972207, DOI: 10.1093/jcag/gwac010.
- Laine L, Sharma P, Mulford DJ, Hunt B, Leifke E, Smith N, Howden CW. Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects. The American Journal Of Gastroenterology 2022, 117: 1158-1161. PMID: 35294415, DOI: 10.14309/ajg.0000000000001735.
- Barkun AN, Douketis J, Noseworthy PA, Laine L, Telford JJ, Abraham NS. Management of Patients on Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Peri-Endoscopic Period: A Clinical Practice Guideline Dissemination Tool. The American Journal Of Gastroenterology 2022, 117: 513-519. PMID: 35354773, DOI: 10.14309/ajg.0000000000001688.
- Gastroinestinal BleedingLaine L. Gastroinestinal Bleeding in Harrison’s Principles of Internal Medicine, 21st Edition. Loscalzo J, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson LJ, Eds. McGraw-Hill Education. 2022; pp. 311-5.
- Gerasimiuk M, Shung D, Tong A, Stanley A, Schultz M, Ngu J, Laine L, Wolf G, Krishnaswamy S. MURAL: An Unsupervised Random Forest-Based Embedding for Electronic Health Record Data. 2021, 00: 4694-4704. DOI: 10.1109/bigdata52589.2021.9672045.
- Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology HospitalistsHughes ML, Li DK, Hung KW, Laine L. Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology Hospitalists. The American Journal Of Gastroenterology 2021, 117: 361-363. PMID: 34904965, DOI: 10.14309/ajg.0000000000001585.
- Zakko A, Zakko L, Grimshaw AA, Laine L. Antiplatelet Monotherapy Is Associated with an Increased Risk of Bleeding After Endoscopic Sphincterotomy. Digestive Diseases And Sciences 2021, 67: 4161-4169. PMID: 34796411, DOI: 10.1007/s10620-021-07302-w.
- Bittl JA, Laine L. Gastrointestinal Injury Caused by Aspirin or Clopidogrel Monotherapy Versus Dual Antiplatelet Therapy ∗. Journal Of The American College Of Cardiology 2021, 79: 129-131. PMID: 34752903, DOI: 10.1016/j.jacc.2021.10.027.
- Sandborn WJ, Feagan BG, D'Haens G, Wolf DC, Jovanovic I, Hanauer SB, Ghosh S, Petersen A, Hua SY, Lee JH, Charles L, Chitkara D, Usiskin K, Colombel JF, Laine L, Danese S. Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis. New England Journal Of Medicine 2021, 385: 1280-1291. PMID: 34587385, DOI: 10.1056/nejmoa2033617.
- Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI. Correction to: ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding. The American Journal Of Gastroenterology 2021, 116: 2309-2309. PMID: 34732677, DOI: 10.14309/ajg.0000000000001506.
- Tran AN, Wang M, Hundt M, Chugh R, Ohm J, Grimshaw A, Ciarleglio M, Hung KW, Proctor DD, Price CC, Laine L, Al-Bawardy B. Immune Checkpoint Inhibitor–associated Diarrhea and Colitis: A Systematic Review and Meta-analysis of Observational Studies. Journal Of Immunotherapy 2021, 44: 325-334. PMID: 34380976, DOI: 10.1097/cji.0000000000000383.
- Jensen DM, Barkun A, Cave D, Gralnek IM, Jutabha R, Laine L, Lau JYW, Saltzman JR, Soetikno R, Sung JJY. Acute gastrointestinal bleeding: proposed study outcomes for new randomised controlled trials. Alimentary Pharmacology & Therapeutics 2021, 54: 616-626. PMID: 34288017, PMCID: PMC9385213, DOI: 10.1111/apt.16483.
- Mohanty A, Kapuria D, Canakis A, Lin H, Amat MJ, Paniz G, Placone NT, Thomasson R, Roy H, Chak E, Baffy G, Curry MP, Laine L, Rustagi T. Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study. Liver International 2021, 41: 1901-1908. PMID: 33969607, DOI: 10.1111/liv.14936.
- Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI. ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding. The American Journal Of Gastroenterology 2021, 116: 899-917. PMID: 33929377, DOI: 10.14309/ajg.0000000000001245.
- Shung D, Huang J, Castro E, Tay JK, Simonov M, Laine L, Batra R, Krishnaswamy S. Neural network predicts need for red blood cell transfusion for patients with acute gastrointestinal bleeding admitted to the intensive care unit. Scientific Reports 2021, 11: 8827. PMID: 33893364, PMCID: PMC8065139, DOI: 10.1038/s41598-021-88226-3.
- Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies. World Journal Of Gastroenterology 2021, 27: 1630-1642. PMID: 33958848, PMCID: PMC8058652, DOI: 10.3748/wjg.v27.i15.1630.
- Sung JJY, Laine L, Kuipers EJ, Barkun AN. Towards personalised management for non-variceal upper gastrointestinal bleeding. Gut 2021, 70: 818-824. PMID: 33649044, DOI: 10.1136/gutjnl-2020-323846.
- Kelly CR, Wu GD, Laine LA. Reply. Gastroenterology 2021, 160: 2636. PMID: 33639155, DOI: 10.1053/j.gastro.2021.02.045.
- Shung D, Tsay C, Laine L, Chang D, Li F, Thomas P, Partridge C, Simonov M, Hsiao A, Tay JK, Taylor A. Early identification of patients with acute gastrointestinal bleeding using natural language processing and decision rules. Journal Of Gastroenterology And Hepatology 2021, 36: 1590-1597. PMID: 33105045, PMCID: PMC11874507, DOI: 10.1111/jgh.15313.
- Dawwas GK, Brensinger CM, Vajravelu RK, Wu Q, Kelly CR, Laine L, Wu GD, Lewis JD. Long-term Outcomes Following Multiply Recurrent Clostridioides difficile Infection and Fecal Microbiota Transplantation. Clinical Gastroenterology And Hepatology 2020, 20: 806-816.e6. PMID: 33307184, PMCID: PMC8184854, DOI: 10.1016/j.cgh.2020.12.004.
- Kelly CR, Yen EF, Grinspan AM, Kahn SA, Atreja A, Lewis JD, Moore TA, Rubin DT, Kim AM, Serra S, Nersesova Y, Fredell L, Hunsicker D, McDonald D, Knight R, Allegretti JR, Pekow J, Absah I, Hsu R, Vincent J, Khanna S, Tangen L, Crawford CV, Mattar MC, Chen LA, Fischer M, Arsenescu RI, Feuerstadt P, Goldstein J, Kerman D, Ehrlich AC, Wu GD, Laine L. Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry. Gastroenterology 2020, 160: 183-192.e3. PMID: 33011173, PMCID: PMC8034505, DOI: 10.1053/j.gastro.2020.09.038.
- Vyas M, Celli R, Singh M, Patel N, Aslanian HR, Boffa D, Deng Y, Ciarleglio MM, Laine L, Jain D. Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction. Human Pathology 2020, 105: 67-73. PMID: 32941964, PMCID: PMC11152084, DOI: 10.1016/j.humpath.2020.08.007.
- Kelly CR, Laine LA, Wu GD. Monitoring Fecal Microbiota Transplantation Practice in a Rapidly Evolving Health and Regulatory Environment. Gastroenterology 2020, 159: 2004-2006. PMID: 32841646, PMCID: PMC7443160, DOI: 10.1053/j.gastro.2020.08.039.
- Laursen SB, Oakland K, Laine L, Bieber V, Marmo R, Redondo-Cerezo E, Dalton HR, Ngu J, Schultz M, Soncini M, Gralnek I, Jairath V, Murray IA, Stanley AJ. ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicentre study. Gut 2020, 70: 707-716. PMID: 32723845, DOI: 10.1136/gutjnl-2019-320002.
- Shung D, Laine L. Machine Learning Prognostic Models for Gastrointestinal Bleeding Using Electronic Health Record Data. The American Journal Of Gastroenterology 2020, 115: 1199-1200. PMID: 32530828, PMCID: PMC7415736, DOI: 10.14309/ajg.0000000000000720.
- Kelly C, Yen E, Grinspan A, Kahn S, Atreja A, Lewis J, Moore T, Rubin D, Kim A, Serra S, Nersesova Y, Fredell L, Hunsicker D, McDonald D, Knight R, Allegretti J, Pekow J, Absah I, Hsu R, Vincent J, Khanna S, Tangen L, Crawford C, Mattar M, Chen L, Fischer M, Arsenescu R, Wu G, Laine L. 37 FECAL MICROBIOTA TRANSPLANATION IS HIGHLY EFFECTIVE IN REAL-WORLD PRACTICE: INITIAL RESULTS FROM THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION FECAL MICROBIOTA TRANSPLANTATION NATIONAL REGISTRY. Gastroenterology 2020, 158: s-14-s-15. DOI: 10.1016/s0016-5085(20)30717-4.
- Barkun AN, Laine L, Leontiadis GI, Bardou M. Management of Nonvariceal Upper Gastrointestinal Bleeding. Annals Of Internal Medicine 2020, 172: 573. PMID: 32311706, DOI: 10.7326/l20-0014.
- Laine L. Timing of Endoscopy in Patients Hospitalized with Upper Gastrointestinal Bleeding. New England Journal Of Medicine 2020, 382: 1361-1363. PMID: 32242363, DOI: 10.1056/nejme2002121.
- Simonov M, Abel EA, Skanderson M, Masoud A, Hauser RG, Brandt CA, Wilson FP, Laine L. Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones. Clinical Gastroenterology And Hepatology 2020, 19: 72-79.e21. PMID: 32147588, PMCID: PMC7483196, DOI: 10.1016/j.cgh.2020.02.053.
- Campbell EV, Muniraj T, Aslanian HR, Laine L, Jamidar P. Musculoskeletal Pain Symptoms and Injuries Among Endoscopists Who Perform ERCP. Digestive Diseases And Sciences 2020, 66: 56-62. PMID: 32144599, DOI: 10.1007/s10620-020-06163-z.
- Laine L, Kaltenbach T, Barkun A, Soetikno R. Chromoendoscopy meta-analysis: correcting subgroup analysis interpretation. Gastrointestinal Endoscopy 2020, 91: 719. PMID: 32087902, DOI: 10.1016/j.gie.2019.08.041.
- Kurlander JE, Rubenstein JH, Richardson CR, Krein SL, De Vries R, Zikmund-Fisher BJ, Yang YX, Laine L, Weissman A, Saini SD. Physicians' Perceptions of Proton Pump Inhibitor Risks and Recommendations to Discontinue: A National Survey. The American Journal Of Gastroenterology 2020, 115: 689-696. PMID: 32091419, PMCID: PMC7196016, DOI: 10.14309/ajg.0000000000000558.
- Lee MW, Pourmorady JS, Laine L. Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2020, 115: 662-670. PMID: 31972617, DOI: 10.14309/ajg.0000000000000495.
- Tsay C, Shung D, Stemmer Frumento K, Laine L. Early Colonoscopy Does Not Improve Outcomes of Patients With Lower Gastrointestinal Bleeding: Systematic Review of Randomized Trials. Clinical Gastroenterology And Hepatology 2019, 18: 1696-1703.e2. PMID: 31843595, PMCID: PMC7292779, DOI: 10.1016/j.cgh.2019.11.061.
- Laine L. Colonoscopy for Lower Gastrointestinal Bleeding—Time Is Not of the Essence. Gastroenterology 2019, 158: 38-39. PMID: 31730767, DOI: 10.1053/j.gastro.2019.11.009.
- Saffouri E, Blackwell C, Laursen SB, Laine L, Dalton HR, Ngu J, Shultz M, Norton R, Stanley AJ. The Shock Index is not accurate at predicting outcomes in patients with upper gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2019, 51: 253-260. PMID: 31642558, DOI: 10.1111/apt.15541.
- Barkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, Leontiadis GI, Abraham NS, Calvet X, Chan FKL, Douketis J, Enns R, Gralnek IM, Jairath V, Jensen D, Lau J, Lip GYH, Loffroy R, Maluf-Filho F, Meltzer AC, Reddy N, Saltzman JR, Marshall JK, Bardou M. Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group. Annals Of Internal Medicine 2019, 171: 805-822. PMID: 31634917, PMCID: PMC7233308, DOI: 10.7326/m19-1795.
- Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD. Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn. New England Journal Of Medicine 2019, 381: 1513-1523. PMID: 31618539, DOI: 10.1056/nejmoa1811424.
- Shung DL, Au B, Taylor RA, Tay JK, Laursen SB, Stanley AJ, Dalton HR, Ngu J, Schultz M, Laine L. Validation of a Machine Learning Model That Outperforms Clinical Risk Scoring Systems for Upper Gastrointestinal Bleeding. Gastroenterology 2019, 158: 160-167. PMID: 31562847, PMCID: PMC7004228, DOI: 10.1053/j.gastro.2019.09.009.
- Redondo‐Cerezo E, Vadillo‐Calles F, Stanley AJ, Laursen S, Laine L, Dalton HR, Ngu JH, Schultz M, Jiménez‐Rosales R. MAP(ASH): A new scoring system for the prediction of intervention and mortality in upper gastrointestinal bleeding. Journal Of Gastroenterology And Hepatology 2019, 35: 82-89. PMID: 31359521, DOI: 10.1111/jgh.14811.
- Shung D, Simonov M, Gentry M, Au B, Laine L. Machine Learning to Predict Outcomes in Patients with Acute Gastrointestinal Bleeding: A Systematic Review. Digestive Diseases And Sciences 2019, 64: 2078-2087. PMID: 31055722, DOI: 10.1007/s10620-019-05645-z.
- Laine L, Ganz RA. Presentation of the Julius M. Friedenwald Medal to John I. Allen. Gastroenterology 2019, 156: 2330-2334. PMID: 31029707, DOI: 10.1053/j.gastro.2019.04.026.
- Laine L. Interventions for Primary Prevention of Esophageal Variceal Bleeding. Hepatology 2019, 69: 1382-1384. PMID: 30561058, DOI: 10.1002/hep.30463.
- Stanley AJ, Laine L. Management of acute upper gastrointestinal bleeding. The BMJ 2019, 364: l536. PMID: 30910853, DOI: 10.1136/bmj.l536.
- Singh M, Sacatos M, Laine L. Impact of Changeover to Newer Endoscopic Systems on Quality and Efficiency of Screening and Surveillance Colonoscopy. Journal Of Clinical Gastroenterology 2018, 52: 891-895. PMID: 28906425, DOI: 10.1097/mcg.0000000000000931.
- Laine L, Laursen SB, Stanley AJ. Outcomes with Bloody vs. Coffee-Grounds Hematemesis. The American Journal Of Gastroenterology 2018, 113: 1727-1728. PMID: 30333532, DOI: 10.1038/s41395-018-0359-2.
- Laine L. Treatment of thrombocytopenic patients with GI bleeding. Gastrointestinal Endoscopy 2018, 88: 62-65. PMID: 29935628, DOI: 10.1016/j.gie.2018.03.003.
- Laine L, Laursen SB, Stanley AJ. Analyses of Bloody vs. Coffee-Grounds Hematemesis. The American Journal Of Gastroenterology 2018, 113: 1253-1254. PMID: 29955117, DOI: 10.1038/s41395-018-0188-3.
- Laine L. Editorial: gastrointestinal safety of COX‐2 selective and nonselective NSAIDs—the impact of the PRECISION trial. Alimentary Pharmacology & Therapeutics 2018, 47: 1545-1546. PMID: 29878414, DOI: 10.1111/apt.14642.
- Dunne P, Laursen SB, Laine L, Dalton HR, Ngu JH, Schultz M, Rahman A, Anderloni A, Murray IA, Stanley AJ. Previous Use of Antithrombotic Agents Reduces Mortality and Length of Hospital Stay in Patients With High-risk Upper Gastrointestinal Bleeding. Clinical Gastroenterology And Hepatology 2018, 17: 440-447.e2. PMID: 29705263, DOI: 10.1016/j.cgh.2018.04.046.
- Scally B, Emberson JR, Spata E, Reith C, Davies K, Halls H, Holland L, Wilson K, Bhala N, Hawkey C, Hochberg M, Hunt R, Laine L, Lanas A, Patrono C, Baigent C. Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: a meta-analysis of randomised trials. The Lancet Gastroenterology & Hepatology 2018, 3: 231-241. PMID: 29475806, PMCID: PMC5842491, DOI: 10.1016/s2468-1253(18)30037-2.
- Laine L, Laursen SB, Zakko L, Dalton HR, Ngu JH, Schultz M, Stanley AJ. Severity and Outcomes of Upper Gastrointestinal Bleeding With Bloody Vs. Coffee-Grounds Hematemesis. The American Journal Of Gastroenterology 2018, 113: 358. PMID: 29380820, DOI: 10.1038/ajg.2018.5.
- Parikh ND, Viana AV, Shah S, Laine L. Image-enhanced endoscopy is specific for the diagnosis of non-erosive gastroesophageal reflux disease. Scandinavian Journal Of Gastroenterology 2018, 53: 260-264. PMID: 29368532, PMCID: PMC6080852, DOI: 10.1080/00365521.2018.1430847.
- Gastroinestinal BleedingLaine L. Gastroinestinal Bleeding in Harrison’s Principles of Internal Medicine, 20th Edition. Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J, Eds. McGraw-Hill Education. 2018; pp. 272-6.
- Buxbaum J, Sahakian A, Ko C, Jayaram P, Lane C, Yu CY, Kankotia R, Laine L. Randomized trial of cholangioscopy-guided laser lithotripsy versus conventional therapy for large bile duct stones (with videos). Gastrointestinal Endoscopy 2017, 87: 1050-1060. PMID: 28866457, DOI: 10.1016/j.gie.2017.08.021.
- Lu Y, Jones DJ, Sharara N, Kaltenbach T, Laine L, McQuaid K, Soetikno R, Subramanian V, Barkun A. Transparency ethics in practice: Revisiting financial conflicts of interest disclosure forms in clinical practice guidelines. PLOS ONE 2017, 12: e0182856. PMID: 28841650, PMCID: PMC5571907, DOI: 10.1371/journal.pone.0182856.
- Kaltenbach TR, Soetikno RM, DeVivo R, Laine LA, Barkun A, McQuaid KR, Group O, Cheifetz A, Chiorean M, East J, Farraye F, Leighton J, Levesque B, Lichtenstein G, Marion J, Matsumoto T, Mönkemüller K, Picco M, Odze R, Raju G, Rutter M, Rex D, Shen B, Shergill A, Subramanian V. Optimizing the quality of endoscopy in inflammatory bowel disease: focus on surveillance and management of colorectal dysplasia using interactive image- and video-based teaching. Gastrointestinal Endoscopy 2017, 86: 1107-1117.e1. PMID: 28818507, DOI: 10.1016/j.gie.2017.07.045.
- Laine L. Is there a role for combined sclerotherapy and ligation in the endoscopic treatment of gastroesophageal varices? Gastrointestinal Endoscopy 2017, 86: 316-318. PMID: 28728669, DOI: 10.1016/j.gie.2017.02.005.
- Hou LA, Laine L, Motamedi N, Sahakian A, Lane C, Buxbaum J. Optimal Timing of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis. Journal Of Clinical Gastroenterology 2017, 51: 534-538. PMID: 27875357, DOI: 10.1097/mcg.0000000000000763.
- Kim SJ, Ohanian E, Lee F, Nam B, Che K, Laine L, Kim SE, Kim JJ. Predictors and outcomes of delayed plastic biliary stent removal following endoscopic retrograde cholangiopancreatography. Scandinavian Journal Of Gastroenterology 2017, 52: 1128-1132. PMID: 28657377, DOI: 10.1080/00365521.2017.1342138.
- Laine L. Bleeding With Direct Oral Anticoagulants: The Gastrointestinal Tract and Beyond. Clinical Gastroenterology And Hepatology 2017, 15: 1665-1667. PMID: 28666949, DOI: 10.1016/j.cgh.2017.06.041.
- Gupta N, Brill JV, Canto M, DeMarco D, Fennerty BM, Laine L, Lieberman D, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Tokar JL, Kochman ML. AGA White Paper: Training and Implementation of Endoscopic Image Enhancement Technologies. Clinical Gastroenterology And Hepatology 2017, 15: 820-826. PMID: 28528939, DOI: 10.1016/j.cgh.2017.01.033.
- Laine L, Laursen SB, Dalton HR, Ngu JH, Schultz M, Stanley AJ. Relationship of time to presentation after onset of upper GI bleeding with patient characteristics and outcomes: a prospective study. Gastrointestinal Endoscopy 2017, 86: 1028-1037. PMID: 28396275, DOI: 10.1016/j.gie.2017.03.1549.
- Buxbaum JL, Hormozdi D, Dinis-Ribeiro M, Lane C, Dias-Silva D, Sahakian A, Jayaram P, Pimentel-Nunes P, Shue D, Pepper M, Cho D, Laine L. Narrow-band imaging versus white light versus mapping biopsy for gastric intestinal metaplasia: a prospective blinded trial. Gastrointestinal Endoscopy 2017, 86: 857-865. PMID: 28366441, DOI: 10.1016/j.gie.2017.03.1528.
- Buxbaum JL, Quezada M, Da B, Jani N, Lane C, Mwengela D, Kelly T, Jhun P, Dhanireddy K, Laine L. Early Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis. The American Journal Of Gastroenterology 2017, 112: 797. PMID: 28266591, DOI: 10.1038/ajg.2017.40.
- Sachar H, Pichetshote N, Nandigam K, Vaidya K, Laine L. Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial. Gastrointestinal Endoscopy 2017, 87: 1297-1303. PMID: 28159539, PMCID: PMC5537051, DOI: 10.1016/j.gie.2017.01.028.
- Kelly CR, Kim AM, Laine L, Wu GD. The AGA’s Fecal Microbiota Transplantation National Registry: An Important Step Toward Understanding Risks and Benefits of Microbiota Therapeutics. Gastroenterology 2017, 152: 681-684. PMID: 28143773, DOI: 10.1053/j.gastro.2017.01.028.
- Stanley AJ, Laine L, Dalton HR, Ngu JH, Schultz M, Abazi R, Zakko L, Thornton S, Wilkinson K, Khor CJ, Murray IA, Laursen SB. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study. The BMJ 2017, 356: i6432. PMID: 28053181, PMCID: PMC5217768, DOI: 10.1136/bmj.i6432.
- Park S, Abdi T, Gentry M, Laine L. Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2016, 111: 1692. PMID: 27725645, DOI: 10.1038/ajg.2016.418.
- Laine L. Upper Gastrointestinal Bleeding Due to a Peptic Ulcer. New England Journal Of Medicine 2016, 375: 1197-1198. PMID: 27653581, DOI: 10.1056/nejmc1609017.
- Laine L. Risk Assessment Tools for Gastrointestinal Bleeding. Clinical Gastroenterology And Hepatology 2016, 14: 1571-1573. PMID: 27521511, DOI: 10.1016/j.cgh.2016.08.003.
- Sheibani S, Khemichian S, Kim JJ, Hou L, Yan AW, Buxbaum J, Dara L, Laine L. Randomized trial of 1‐week versus 2‐week intervals for endoscopic ligation in the treatment of patients with esophageal variceal bleeding. Hepatology 2016, 64: 549-555. PMID: 27082942, PMCID: PMC4956532, DOI: 10.1002/hep.28597.
- Zakko L, Rustagi T, Douglas M, Laine L. No Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents. Clinical Gastroenterology And Hepatology 2016, 15: 46-52. PMID: 27464591, DOI: 10.1016/j.cgh.2016.07.017.
- Buxbaum J, Leonor P, Tung J, Lane C, Sahakian A, Laine L. Randomized Trial of Endoscopist-Controlled vs. Assistant-Controlled Wire-Guided Cannulation of the Bile Duct. The American Journal Of Gastroenterology 2016, 111: 1841. PMID: 27377519, DOI: 10.1038/ajg.2016.268.
- Laine L. Upper Gastrointestinal Bleeding Due to a Peptic Ulcer. New England Journal Of Medicine 2016, 374: 2367-2376. PMID: 27305194, DOI: 10.1056/nejmcp1514257.
- Parikh ND, Chaptini L, Njei B, Laine L. Diagnosis of sessile serrated adenomas/polyps with image-enhanced endoscopy: a systematic review and meta-analysis. Endoscopy 2016, 48: 731-739. PMID: 27223636, DOI: 10.1055/s-0042-107592.
- Graham DY, Laine L. The Toronto Helicobacter pylori Consensus in Context. Gastroenterology 2016, 151: 9-12. PMID: 27215659, PMCID: PMC6910198, DOI: 10.1053/j.gastro.2016.05.009.
- Popov VB, Thompson CC, Kumar N, Ciarleglio MM, Deng Y, Laine L. Effect of Intragastric Balloons on Liver Enzymes: A Systematic Review and Meta-Analysis. Digestive Diseases And Sciences 2016, 61: 2477-2487. PMID: 27207181, DOI: 10.1007/s10620-016-4178-2.
- Park S, Laine L. Pursuing a Clinical Academic Career During Gastroenterology Fellowship. Digestive Diseases And Sciences 2016, 61: 2162-2164. PMID: 27193565, DOI: 10.1007/s10620-016-4196-0.
- Vaduganathan M, Cannon CP, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Bhatt DL, Investigators C. Efficacy and Safety of Proton-Pump Inhibitors in High-Risk Cardiovascular Subsets of the COGENT Trial. The American Journal Of Medicine 2016, 129: 1002-1005. PMID: 27143321, DOI: 10.1016/j.amjmed.2016.03.042.
- Laine L, Nagar A. Long-Term PPI Use: Balancing Potential Harms and Documented Benefits. The American Journal Of Gastroenterology 2016, 111: 913. PMID: 27113114, DOI: 10.1038/ajg.2016.156.
- Clark BT, Laine L. High-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps. Clinical Gastroenterology And Hepatology 2016, 14: 1155-1162. PMID: 27060426, PMCID: PMC4955697, DOI: 10.1016/j.cgh.2016.03.044.
- Soetikno R, Kaltenbach T, McQuaid KR, Subramanian V, Kumar R, Barkun AN, Laine L. Paradigm Shift in the Surveillance and Management of Dysplasia in Inflammatory Bowel Disease (West). Digestive Endoscopy 2016, 28: 266-273. PMID: 26866420, DOI: 10.1111/den.12634.
- Vaduganathan M, Bhatt DL, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Cannon CP, Investigators C. Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. Journal Of The American College Of Cardiology 2016, 67: 1661-1671. PMID: 27012778, DOI: 10.1016/j.jacc.2015.12.068.
- Clark BT, Parikh ND, Laine L. Yield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy. Gastrointestinal Endoscopy 2016, 84: 126-132. PMID: 26769408, PMCID: PMC4912931, DOI: 10.1016/j.gie.2015.12.030.
- Langberg KM, Parikh ND, Deng Y, Ciarlegio M, Laine L, Aslanian HR. Digital chromoendoscopy utilization in clinical practice: A survey of gastroenterologists in Connecticut. World Journal Of Gastrointestinal Pharmacology And Therapeutics 2016, 7: 268-73. PMID: 27158543, PMCID: PMC4848250, DOI: 10.4292/wjgpt.v7.i2.268.
- Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR. Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP? Digestive Diseases And Sciences 2015, 61: 722-730. PMID: 26572779, DOI: 10.1007/s10620-015-3939-7.
- Rustagi T, Aslanian HR, Laine L. Treatment of Refractory Gastrointestinal Strictures With Mitomycin C. Journal Of Clinical Gastroenterology 2015, 49: 837-847. PMID: 25626632, DOI: 10.1097/mcg.0000000000000295.
- Sharma P, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lieberman D, Lightdale C, Montgomery E, Odze R, Tokar J, Kochman M. White Paper AGA: Advanced Imaging in Barrett’s Esophagus. Clinical Gastroenterology And Hepatology 2015, 13: 2209-2218. PMID: 26462567, DOI: 10.1016/j.cgh.2015.09.017.
- Clark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L. Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology 2015, 150: 396-405. PMID: 26439436, PMCID: PMC4728019, DOI: 10.1053/j.gastro.2015.09.041.
- Njei B, Laine L. Early Use of TIPS and Outcomes in Patients With Cirrhosis and Acute Esophageal Variceal Bleeding: Analysis of the U.S. Nationwide Inpatient Sample (NIS) Database, 2000-2010: ACG Fellows-In-Training Award. The American Journal Of Gastroenterology 2015, 110: s870. DOI: 10.14309/00000434-201510001-02070.
- He H, Tan C, Wu J, Dai N, Hu W, Scheiman J, Laine L, Kim J. Suboptimal Specificity of ASGE High-Risk Group in Evaluation of Patients With Suspected Choledocholithiasis. The American Journal Of Gastroenterology 2015, 110: s9. DOI: 10.14309/00000434-201510001-00018.
- Sanduleanu S, Kaltenbach T, Barkun A, McCabe RP, Velayos F, Picco MF, Laine L, Soetikno R, McQuaid KR. A roadmap to the implementation of chromoendoscopy in inflammatory bowel disease colonoscopy surveillance practice. Gastrointestinal Endoscopy 2015, 83: 213-222. PMID: 26364967, DOI: 10.1016/j.gie.2015.08.076.
- Lieberman D, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Kochman M, Tokar J. Management of Diminutive Colon Polyps Based on Endoluminal Imaging. Clinical Gastroenterology And Hepatology 2015, 13: 1860-1866. PMID: 26192139, DOI: 10.1016/j.cgh.2015.07.011.
- Vardi M, Cryer BL, Cohen M, Lanas A, Schnitzer TJ, Lapuerta P, Goldsmith MA, Laine L, Doros G, Liu Y, McIntosh AI, Cannon CP, Bhatt DL. The effects of proton pump inhibition on patient‐reported severity of dyspepsia when receiving dual anti‐platelet therapy with clopidogrel and low‐dose aspirin: analysis from the Clopidogrel and the Optimization of Gastrointestinal Events Trial. Alimentary Pharmacology & Therapeutics 2015, 42: 365-374. PMID: 26032114, PMCID: PMC4494867, DOI: 10.1111/apt.13260.
- Lee F, Ohanian E, Rheem J, Laine L, Che K, Kim JJ. Delayed endoscopic retrograde cholangiopancreatography is associated with persistent organ failure in hospitalised patients with acute cholangitis. Alimentary Pharmacology & Therapeutics 2015, 42: 212-220. PMID: 25997554, DOI: 10.1111/apt.13253.
- Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and OutlookKelly CR, Kahn S, Kashyap P, Laine L, Rubin D, Atreja A, Moore T, Wu G. Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook. Gastroenterology 2015, 149: 223-237. PMID: 25982290, PMCID: PMC4755303, DOI: 10.1053/j.gastro.2015.05.008.
- Yan K, Bridges J, Augustin S, Laine L, Garcia-Tsao G, Fraenkel L. Factors impacting physicians’ decisions to prevent variceal hemorrhage. BMC Gastroenterology 2015, 15: 55. PMID: 25934271, PMCID: PMC4423490, DOI: 10.1186/s12876-015-0287-1.
- Chaptini L, Laine L. Can I Improve My Adenoma Detection Rate? Journal Of Clinical Gastroenterology 2015, 49: 270-281. PMID: 25647725, DOI: 10.1097/mcg.0000000000000293.
- Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, Panel S, East J, Farraye F, Feagan B, Ioannidis J, Kiesslich R, Krier M, Matsumoto T, McCabe R, Mönkemüller K, Odze R, Picco M, Rubin D, Rubin M, Rubio C, Rutter M, Sanchez-Yague A, Sanduleanu S, Shergill A, Ullman T, Velayos F, Yakich D, Yang Y. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastrointestinal Endoscopy 2015, 81: 489-501.e26. PMID: 25708752, DOI: 10.1016/j.gie.2014.12.009.
- Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, Panel S, East J, Farraye F, Feagan B, Ioannidis J, Kiesslich R, Krier M, Matsumoto T, McCabe R, Mönkemüller K, Odze R, Picco M, Rubin D, Rubin M, Rubio C, Rutter M, Sanchez-Yague A, Sanduleanu S, Shergill A, Ullman T, Velayos F, Yakich D, Yang Y. SCENIC International Consensus Statement on Surveillance and Management of Dysplasia in Inflammatory Bowel Disease. Gastroenterology 2015, 148: 639-651.e28. PMID: 25702852, DOI: 10.1053/j.gastro.2015.01.031.
- Gastroinestinal BleedingLaine L. Gastroinestinal Bleeding in Gastrointestinal Bleeding. In Harrison’s Principles of Internal Medicine, 19th Edition. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, Eds. McGraw-Hill Education. 2015; pp. 276-9.
- Park WG, Shaheen NJ, Cohen J, Pike IM, Adler DG, Inadomi JM, Laine LA, Lieb JG, Rizk MK, Sawhney MS, Wani S. Quality indicators for EGD. Gastrointestinal Endoscopy 2014, 81: 17-30. PMID: 25480101, DOI: 10.1016/j.gie.2014.07.057.
- Park WG, Shaheen NJ, Cohen J, Pike IM, Adler DG, Inadomi JM, Laine LA, Lieb JG, Rizk MK, Sawhney MS, Wani S. Quality Indicators for EGD. The American Journal Of Gastroenterology 2014, 110: 60. PMID: 25448872, DOI: 10.1038/ajg.2014.384.
- Sachar H, Vaidya K, Laine L. Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis. JAMA Internal Medicine 2014, 174: 1755-1762. PMID: 25201154, PMCID: PMC4415726, DOI: 10.1001/jamainternmed.2014.4056.
- Kim JJ, Walia S, Lee SH, Patel B, Vetsa M, Zhao Y, Srikureja W, Laine L. Lower Yield of Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Patients with Pancreatic Head Mass with a Biliary Stent. Digestive Diseases And Sciences 2014, 60: 543-549. PMID: 25245115, DOI: 10.1007/s10620-014-3367-0.
- Laine L. NSAID-Associated Gastrointestinal Bleeding: Assessing the Role of Concomitant Medications. Gastroenterology 2014, 147: 730-733. PMID: 25167988, DOI: 10.1053/j.gastro.2014.08.021.
- Clark BT, Rustagi T, Laine L. What Level of Bowel Prep Quality Requires Early Repeat Colonoscopy: Systematic Review and Meta-Analysis of the Impact of Preparation Quality on Adenoma Detection Rate. The American Journal Of Gastroenterology 2014, 109: 1714. PMID: 25135006, PMCID: PMC4423726, DOI: 10.1038/ajg.2014.232.
- Chaptini L, Chaaya A, Depalma F, Hunter K, Peikin S, Laine L. Variation in polyp size estimation among endoscopists and impact on surveillance intervals. Gastrointestinal Endoscopy 2014, 80: 652-659. PMID: 24679658, DOI: 10.1016/j.gie.2014.01.053.
- Kim JJ, Lee JS, Olafsson S, Laine L. Low Adherence to Helicobacter pylori Testing in Hospitalized Patients with Bleeding Peptic Ulcer Disease. Helicobacter 2014, 19: 98-104. PMID: 24617668, DOI: 10.1111/hel.12114.
- Kim JJ, Sheibani S, Park S, Buxbaum J, Laine L. Causes of Bleeding and Outcomes in Patients Hospitalized With Upper Gastrointestinal Bleeding. Journal Of Clinical Gastroenterology 2014, 48: 113-118. PMID: 23685847, DOI: 10.1097/mcg.0b013e318297fb40.
- Kim JJ, Han A, Yan AW, Cao D, Laine L. Gastroenterologists’ Practice Patterns for Positive Fecal Occult Blood Test. Journal Of Clinical Gastroenterology 2014, 48: 119-126. PMID: 23632353, DOI: 10.1097/mcg.0b013e31828f1c8d.
- Sahakian AB, Aslanian HR, Mehra M, Rossi F, Laine L, Sanchez M, Ciarleglio MM, Adimoolam V, Siddiqui UD. The Utility of Esophagogastroduodenoscopy Before Endoscopic Ultrasonography in Patients Undergoing Endoscopic Ultrasonography for Pancreatico-biliary and Mediastinal Indications. Journal Of Clinical Gastroenterology 2013, 47: 857-860. PMID: 23632349, DOI: 10.1097/mcg.0b013e31828ba28c.
- Hecht GA, Blaser MJ, Gordon J, Kaplan LM, Knight R, Laine L, Peek R, Sanders ME, Sartor B, Wu GD, Yang VW. What Is the Value of a Food and Drug Administration Investigational New Drug Application for Fecal Microbiota Transplantation to Treat Clostridium difficile Infection? Clinical Gastroenterology And Hepatology 2013, 12: 289-291. PMID: 24148361, DOI: 10.1016/j.cgh.2013.10.009.
- Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, Bombardier C, Cannon C, Farkouh ME, FitzGerald GA, Goss P, Halls H, Hawk E, Hawkey C, Hennekens C, Hochberg M, Holland LE, Kearney PM, Laine L, Lanas A, Lance P, Laupacis A, Oates J, Patrono C, Schnitzer TJ, Solomon S, Tugwell P, Wilson K, Wittes J, Baigent C. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet 2013, 382: 769-79. PMID: 23726390, PMCID: PMC3778977, DOI: 10.1016/S0140-6736(13)60900-9.
- Buxbaum J, Yan A, Yeh K, Lane C, Nguyen N, Laine L. Aggressive Hydration With Lactated Ringer's Solution Reduces Pancreatitis After Endoscopic Retrograde Cholangiopancreatography. Clinical Gastroenterology And Hepatology 2013, 12: 303-307.e1. PMID: 23920031, PMCID: PMC3879172, DOI: 10.1016/j.cgh.2013.07.026.
- Saliminejad M, Bemanian S, Ho A, Spiegel B, Laine L. The yield and cost of colonoscopy in patients with metastatic cancer of unknown primary. Alimentary Pharmacology & Therapeutics 2013, 38: 628-633. PMID: 23869398, DOI: 10.1111/apt.12429.
- Sheibani S, Kim JJ, Chen B, Park S, Saberi B, Keyashian K, Buxbaum J, Laine L. Natural history of acute upper GI bleeding due to tumours: short‐term success and long‐term recurrence with or without endoscopic therapy. Alimentary Pharmacology & Therapeutics 2013, 38: 144-150. PMID: 23710797, DOI: 10.1111/apt.12347.
- Aslanian HR, Laine L. Hemostatic powder spray for GI bleeding. Gastrointestinal Endoscopy 2013, 77: 508-510. PMID: 23410702, DOI: 10.1016/j.gie.2012.11.034.
- de Groot NL, van Haalen HG, Spiegel BM, Laine L, Lanas A, Focks JJ, Siersema PD, van Oijen MG. Gastroprotection in Low-Dose Aspirin Users for Primary and Secondary Prevention of ACS: Results of a Cost-Effectiveness Analysis Including Compliance. Cardiovascular Drugs And Therapy 2013, 27: 341-357. PMID: 23417566, DOI: 10.1007/s10557-013-6448-y.
- Laine L. Blood Transfusion for Gastrointestinal Bleeding. New England Journal Of Medicine 2013, 368: 75-76. PMID: 23281980, DOI: 10.1056/nejme1212009.
- Kim J, Sara S, Sunhee P, Chen B, Buxbaum J, Laine L. High Frequency of Varices as a Cause of Upper GI Bleeding in Low-Socioeconomic-Status Patients. The American Journal Of Gastroenterology 2012, 107: s755-s756. DOI: 10.14309/00000434-201210001-01856.
- Enestvedt BK, Tofani C, Laine LA, Tierney A, Fennerty MB. 4-Liter Split-Dose Polyethylene Glycol Is Superior to Other Bowel Preparations, Based on Systematic Review and Meta-analysis. Clinical Gastroenterology And Hepatology 2012, 10: 1225-1231. PMID: 22940741, DOI: 10.1016/j.cgh.2012.08.029.
- Laine L, Kivitz A, Bello A, Grahn A, Schiff M, Taha A. Corrigendum: Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers. The American Journal Of Gastroenterology 2012, 107: 1272. DOI: 10.1038/ajg.2012.244.
- Laine L, Yang H, Chang SC, Datto C. Trends for Incidence of Hospitalization and Death Due to GI Complications in the United States From 2001 to 2009. The American Journal Of Gastroenterology 2012, 107: 1190. PMID: 22688850, DOI: 10.1038/ajg.2012.168.
- Dadabhai AS, Fenkel JM, Brown DB, Laine L. Balloon‐occluded retrograde transvenous obliteration for the treatment of gastric varices. Hepatology 2012, 55: 1301-1304. PMID: 22318957, DOI: 10.1002/hep.25635.
- Laine L, Jensen DM. Management of Patients With Ulcer Bleeding. The American Journal Of Gastroenterology 2012, 107: 345. PMID: 22310222, DOI: 10.1038/ajg.2011.480.
- Gastroinestinal BleedingLaine L. Gastroinestinal Bleeding in Harrison’s Principles of Internal Medicine, 18th Edition. Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, Eds. The McGraw-Hill Companies, Inc. 2012; pp. 320-4.
- Laine L, Kivitz AJ, Bello AE, Grahn AY, Schiff MH, Taha AS. Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers. The American Journal Of Gastroenterology 2011, 107: ajg2011443. PMID: 22186979, PMCID: PMC3321505, DOI: 10.1038/ajg.2011.443.
- Ruff CT, Morrow DA, Jarolim P, Ren F, Contant CF, Kaur A, Curtis SP, Laine L, Cannon CP, Brune K. Evaluation of NT-proBNP and high sensitivity C-reactive protein for predicting cardiovascular risk in patients with arthritis taking longterm nonsteroidal antiinflammatory drugs. The Journal Of Rheumatology 2011, 38: 1071-8. PMID: 21459935, DOI: 10.3899/jrheum.100880.
- Laine L. Proton Pump Inhibitor Co-therapy With Clopidogrel: Is There GI Benefit or Cardiovascular Harm? Gastroenterology 2011, 140: 769-772.e2. PMID: 21266209, DOI: 10.1053/j.gastro.2011.01.024.
- Documents A, Abraham N, Hlatky M, Antman E, Bhatt D, Bjorkman D, Clark C, Furberg C, Johnson D, Kahi C, Laine L, Mahaffey K, Quigley E, Scheiman J, Sperling L, Tomaselli G. ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. Journal Of The American College Of Cardiology 2010, 56: 2051-2066. PMID: 21126648, DOI: 10.1016/j.jacc.2010.09.010.
- Abraham NS, Hlatky MA, Antman EM, Bhatt DL, Bjorkman DJ, Clark CB, Furberg CD, Johnson DA, Kahi CJ, Laine L, Mahaffey KW, Quigley EM, Scheiman J, Sperling LS, Tomaselli GF. ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. The American Journal Of Gastroenterology 2010, 105: 2533. PMID: 21131924, DOI: 10.1038/ajg.2010.445.
- Laine L, Katz PO, Johnson DA, Ibegbu I, Goldstein MJ, Chou C, Rossiter G, Lu Y. Randomised clinical trial: a novel rabeprazole extended release 50 mg formulation vs. esomeprazole 40 mg in healing of moderate‐to‐severe erosive oesophagitis – the results of two double‐blind studies. Alimentary Pharmacology & Therapeutics 2010, 33: 203-212. PMID: 21114792, DOI: 10.1111/j.1365-2036.2010.04516.x.
- Laine L, Abid S, Albillos A, Kamath P, Vinel J, García‐Pagán J. Treatment of Acute Bleeding. 2010, 101-118. DOI: 10.1002/9781444393989.ch10.
- Members W, Abraham N, Hlatky M, Antman E, Bhatt D, Bjorkman D, Clark C, Furberg C, Johnson D, Kahi C, Laine L, Mahaffey K, Quigley E, Scheiman J, Sperling L, Tomaselli G. ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. Circulation 2010, 122: 2619-2633. PMID: 21060077, DOI: 10.1161/cir.0b013e318202f701.
- Bhatt DL, Cryer BL, Contant CF, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Scirica BM, Murphy SA, Cannon CP. Clopidogrel with or without Omeprazole in Coronary Artery Disease. New England Journal Of Medicine 2010, 363: 1909-1917. PMID: 20925534, DOI: 10.1056/nejmoa1007964.
- Laine L, Curtis SP, Cryer B, Kaur A, Cannon CP. Risk factors for NSAID‐associated upper GI clinical events in a long‐term prospective study of 34 701 arthritis patients. Alimentary Pharmacology & Therapeutics 2010, 32: 1240-1248. PMID: 20955443, DOI: 10.1111/j.1365-2036.2010.04465.x.
- Laine L, Shah A. Randomized Trial of Urgent vs. Elective Colonoscopy in Patients Hospitalized With Lower GI Bleeding. The American Journal Of Gastroenterology 2010, 105: 2636. PMID: 20648004, DOI: 10.1038/ajg.2010.277.
- Laine L. Primary prophylaxis of esophageal variceal bleeding: An endoscopic approach. Journal Of Hepatology 2010, 52: 944-945. PMID: 20381891, DOI: 10.1016/j.jhep.2009.12.035.
- Laine L, Sahota A, Shah A. Does Capsule Endoscopy Improve Outcomes in Obscure Gastrointestinal Bleeding? Randomized Trial Versus Dedicated Small Bowel Radiography. Gastroenterology 2010, 138: 1673-1680.e1. PMID: 20138043, DOI: 10.1053/j.gastro.2010.01.047.
- Kim JJ, Simpson N, Klipfel N, DeBose R, Barr N, Laine L. Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease. Digestive Diseases And Sciences 2010, 55: 1059-1065. PMID: 20112061, DOI: 10.1007/s10620-010-1126-4.
- Laine L, Spiegel B, Rostom A, Moayyedi P, Kuipers EJ, Bardou M, Sung J, Barkun AN. Methodology for Randomized Trials of Patients With Nonvariceal Upper Gastrointestinal Bleeding: Recommendations From an International Consensus Conference. The American Journal Of Gastroenterology 2009, 105: ajg2009702. PMID: 20029415, DOI: 10.1038/ajg.2009.702.
- Laine L, Hennekens C. Proton Pump Inhibitor and Clopidogrel Interaction: Fact or Fiction? The American Journal Of Gastroenterology 2009, 105: ajg2009638. PMID: 19904241, DOI: 10.1038/ajg.2009.638.
- LAINE L, CONNORS L, GRIFFIN MR, CURTIS SP, KAUR A, CANNON CP. Prescription rates of protective co‐therapy for NSAID users at high GI risk and results of attempts to improve adherence to guidelines. Alimentary Pharmacology & Therapeutics 2009, 30: 767-774. PMID: 19594486, DOI: 10.1111/j.1365-2036.2009.04090.x.
- Krum H, Curtis SP, Kaur A, Wang H, Smugar SS, Weir MR, Laine L, Brater DC, Cannon CP. Baseline factors associated with congestive heart failure in patients receiving etoricoxib or diclofenac: multivariate analysis of the MEDAL program. European Journal Of Heart Failure 2009, 11: 542-550. PMID: 19380329, DOI: 10.1093/eurjhf/hfp054.
- Saliminejad M, Bemanian S, Chen J, Laine L. Yield and Cost of Colonoscopy in Patients with Metastatic Cancer of Unknown Primary. Gastrointestinal Endoscopy 2009, 69: ab277. DOI: 10.1016/j.gie.2009.03.743.
- Laine L, Sahota A, Shah A. Does Capsule Endoscopy Improve Outcomes in Obscure GI Bleeding: Randomized Controlled Trial of Capsule Endoscopy vs. Dedicated Small Bowel Radiography. Gastrointestinal Endoscopy 2009, 69: ab99. DOI: 10.1016/j.gie.2009.03.042.
- Krum H, Swergold G, Curtis SP, Kaur A, Wang H, Smugar SS, Weir MR, Laine L, Brater DC, Cannon CP. Factors associated with blood pressure changes in patients receiving diclofenac or etoricoxib: results from the MEDAL study. Journal Of Hypertension 2009, 27: 886-893. PMID: 19516186, DOI: 10.1097/hjh.0b013e328325d831.
- Laine L. Proton Pump Inhibitors and Bone Fractures? The American Journal Of Gastroenterology 2009, 104: ajg200948. PMID: 19262543, DOI: 10.1038/ajg.2009.48.
- Combe B, Swergold G, McLay J, McCarthy T, Zerbini C, Emery P, Connors L, Kaur A, Curtis S, Laine L, Cannon CP. Cardiovascular safety and gastrointestinal tolerability of etoricoxib vs diclofenac in a randomized controlled clinical trial (The MEDAL study). Rheumatology 2009, 48: 425-432. PMID: 19223284, DOI: 10.1093/rheumatology/kep005.
- Laine L, Goldkind L, Curtis SP, Connors LG, Yanqiong Z, Cannon CP. How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial. The American Journal Of Gastroenterology 2009, 104: ajg2008149. PMID: 19174782, DOI: 10.1038/ajg.2008.149.
- Sharma P, Chey W, Hunt R, Laine L, Malfertheiner P, Wani S. Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective. Diseases Of The Esophagus 2009, 22: 461-466. PMID: 19191851, DOI: 10.1111/j.1442-2050.2008.00934.x.
- SPIEGEL BM, FARID M, VAN OIJEN MG, LAINE L, HOWDEN CW, ESRAILIAN E. Adherence to best practice guidelines in dyspepsia: a survey comparing dyspepsia experts, community gastroenterologists and primary‐care providers. Alimentary Pharmacology & Therapeutics 2009, 29: 871-881. PMID: 19183152, PMCID: PMC2953468, DOI: 10.1111/j.1365-2036.2009.03935.x.
- Palta R, Sahota A, Bemarki A, Salama P, Simpson N, Laine L. Foreign-body ingestion: characteristics and outcomes in a lower socioeconomic population with predominantly intentional ingestion. Gastrointestinal Endoscopy 2008, 69: 426-433. PMID: 19019363, DOI: 10.1016/j.gie.2008.05.072.
- ESRAILIAN E, GRALNEK IM, JENSEN D, LAINE L, DULAI GS, EISEN G, SPIEGEL BM. Evaluating the process of care in nonvariceal upper gastrointestinal haemorrhage: a survey of expert vs. non‐expert gastroenterologists. Alimentary Pharmacology & Therapeutics 2008, 28: 1199-1208. PMID: 18729846, DOI: 10.1111/j.1365-2036.2008.03838.x.
- Chan FK, Abraham NS, Scheiman JM, Laine L. Management of Patients on Nonsteroidal Anti-inflammatory Drugs: A Clinical Practice Recommendation From the First International Working Party on Gastrointestinal and Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs and Anti-platelet Agents. The American Journal Of Gastroenterology 2008, 103: ajg2008576. PMID: 18853980, DOI: 10.1111/j.1572-0241.2008.02200.x.
- Zhao Y, Ma Y, Vikas P, Laine L. Macroscopic Colitis in Microscopic Colitis. The American Journal Of Gastroenterology 2008, 103: s183. DOI: 10.14309/00000434-200809001-00476.
- Laine L, McQuaid KR. Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials. Clinical Gastroenterology And Hepatology 2008, 7: 33-47. PMID: 18986845, DOI: 10.1016/j.cgh.2008.08.016.
- Elmunzer BJ, Young SD, Inadomi JM, Schoenfeld P, Laine L. Systematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers. The American Journal Of Gastroenterology 2008, 103: ajg2008521. PMID: 18684171, DOI: 10.1111/j.1572-0241.2008.02070.x.
- Laine L, Curtis SP, Langman M, Jensen DM, Cryer B, Kaur A, Cannon CP. Lower Gastrointestinal Events in a Double-Blind Trial of the Cyclo-Oxygenase-2 Selective Inhibitor Etoricoxib and the Traditional Nonsteroidal Anti-Inflammatory Drug Diclofenac. Gastroenterology 2008, 135: 1517-1525. PMID: 18823986, DOI: 10.1053/j.gastro.2008.07.067.
- Laine L, Takeuchi K, Tarnawski A. Gastric Mucosal Defense and Cytoprotection: Bench to Bedside. Gastroenterology 2008, 135: 41-60. PMID: 18549814, DOI: 10.1053/j.gastro.2008.05.030.
- Vakil N, Laine L, Talley NJ, Zakko SF, Tack J, Chey WD, Kralstein J, Earnest DL, Ligozio G, Cohard-Radice M. Tegaserod Treatment for Dysmotility-Like Functional Dyspepsia: Results of Two Randomized, Controlled Trials. The American Journal Of Gastroenterology 2008, 103: ajg2008383. PMID: 18616658, DOI: 10.1111/j.1572-0241.2008.01953.x.
- McQuaid KR, Laine L. A systematic review and meta-analysis of randomized, controlled trials of moderate sedation for routine endoscopic procedures. Gastrointestinal Endoscopy 2008, 67: 910-923. PMID: 18440381, DOI: 10.1016/j.gie.2007.12.046.
- de Franchis R, Eisen GM, Laine L, Fernandez‐Urien I, Herrerias JM, Brown RD, Fisher L, Vargas HE, Vargo J, Thompson J, Eliakim R. Esophageal capsule endoscopy for screening and surveillance of esophageal varices in patients with portal hypertension. Hepatology 2008, 47: 1595-1603. PMID: 18435461, DOI: 10.1002/hep.22227.
- Laine L, Shah A, Bemanian S. Intragastric pH With Oral vs Intravenous Bolus Plus Infusion Proton-Pump Inhibitor Therapy in Patients With Bleeding Ulcers. Gastroenterology 2008, 134: 1836-1841. PMID: 18423628, DOI: 10.1053/j.gastro.2008.03.006.
- Laine L, Long GL, Bakos GJ, Vakharia OJ, Cunningham C. Optimizing bipolar electrocoagulation for endoscopic hemostasis: assessment of factors influencing energy delivery and coagulation. Gastrointestinal Endoscopy 2008, 67: 502-508. PMID: 18294513, DOI: 10.1016/j.gie.2007.09.025.
- Laine L, White WB, Rostom A, Hochberg M. COX-2 Selective Inhibitors in the Treatment of Osteoarthritis. Seminars In Arthritis And Rheumatism 2008, 38: 165-187. PMID: 18177922, DOI: 10.1016/j.semarthrit.2007.10.004.
- Gastroinestinal BleedingLaine L. Gastroinestinal Bleeding in Harrison’s Principles of Internal Medicine, 17th Edition. Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, Eds. The McGraw-Hill Companies, Inc. 2008; pp. 257-60.
- Schreiner GC, Laine L, Murphy SA, Cannon CP. Evaluation of Proton Pump Inhibitor Use in Patients With Acute Coronary Syndromes Based on Risk Factors for Gastrointestinal Bleed. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2007, 6: 169-172. PMID: 18091407, DOI: 10.1097/hpc.0b013e318159921e.
- Fried M, Quigley E, Hunt R, Guyatt G, Anderson B, Bjorkman D, Farthing M, Fedail S, Green-Thompson R, Hampton J, Krabshuis J, Laine L, Horton R. Is an evidence-based approach to creating guidelines always the right one? Nature Reviews Gastroenterology & Hepatology 2007, 5: 60-61. PMID: 17998924, DOI: 10.1038/ncpgasthep0997.
- Fried M, Quigley E, Hunt R, Guyatt G, Anderson B, Bjorkman D, Farthing M, Fedail S, Green-Thompson R, Hampton J, Krabshuis J, Laine L, Horton R. Can global guidelines change health policy? Nature Reviews Gastroenterology & Hepatology 2007, 5: 120-121. PMID: 17998923, DOI: 10.1038/ncpgasthep0998.
- Fried M, Quigley E, Hunt R, Guyatt G, Anderson B, Bjorkman D, Farthing M, Fedail S, Green-Thompson R, Hampton J, Krabshuis J, Laine L, Horton R. Are global guidelines desirable, feasible and necessary? Nature Reviews Gastroenterology & Hepatology 2007, 5: 2-3. PMID: 17998926, DOI: 10.1038/ncpgasthep0994.
- Laine L, Curtis SP, Cryer B, Kaur A, Cannon CP, Committee F. Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. The Lancet 2007, 369: 465-473. PMID: 17292766, DOI: 10.1016/s0140-6736(07)60234-7.
- Laine L. Upper gastrointestinal bleeding. Clinical Update 2007, 14: 1-4. DOI: 10.1016/j.clinup.2006.12.001.
- McQuaid K, Laine L. Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials. American Journal Of Ophthalmology 2007, 143: 194. DOI: 10.1016/j.ajo.2006.11.002.
- Cannon CP, Curtis SP, FitzGerald GA, Krum H, Kaur A, Bolognese JA, Reicin AS, Bombardier C, Weinblatt ME, van der Heijde D, Erdmann E, Laine L, Committee F. Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. The Lancet 2006, 368: 1771-1781. PMID: 17113426, DOI: 10.1016/s0140-6736(06)69666-9.
- LAINE L. Review article: gastrointestinal bleeding with low‐dose aspirin – what's the risk? Alimentary Pharmacology & Therapeutics 2006, 24: 897-908. PMID: 16948802, DOI: 10.1111/j.1365-2036.2006.03077.x.
- LAINE L, SMITH R, MIN K, CHEN C, DUBOIS RW. Systematic review: the lower gastrointestinal adverse effects of non‐steroidal anti‐inflammatory drugs. Alimentary Pharmacology & Therapeutics 2006, 24: 751-767. PMID: 16918879, DOI: 10.1111/j.1365-2036.2006.03043.x.
- Laine L. The gastroenterology boards. Gastrointestinal Endoscopy 2006, 64: 246-247. DOI: 10.1016/j.gie.2006.04.021.
- Bolognese J, Cannon C, Curtis S, Laine L. THE MEDAL PROGRAM DESIGN: THREE RANDOMIZED TRIALS IN 34,701 PATIENTS WITH OA OR RA TO EVALUATE CARDIOVASCULAR SAFETY OF ETORICOXIB VERSUS DICLOFENAC. JCR Journal Of Clinical Rheumatology 2006, 12: s85-s86. DOI: 10.1097/01.rhu.0000233330.39079.13.
- McQuaid KR, Laine L. Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials. The American Journal Of Medicine 2006, 119: 624-638. PMID: 16887404, DOI: 10.1016/j.amjmed.2005.10.039.
- Cannon CP, Curtis SP, Bolognese JA, Laine L, Committee F. Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) Study Program: Cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis. American Heart Journal 2006, 152: 237-245. PMID: 16875903, DOI: 10.1016/j.ahj.2006.05.024.
- PAIS SA, NATHWANI RA, DHAR V, NOWAIN A, LAINE L. Effect of frequent dosing of an oral proton pump inhibitor on intragastric pH. Alimentary Pharmacology & Therapeutics 2006, 23: 1607-1613. PMID: 16696810, DOI: 10.1111/j.1365-2036.2006.02933.x.
- Laine L. GI Risk and Risk Factors of NSAIDs. Journal Of Cardiovascular Pharmacology 2006, 47: s60-s66. PMID: 16785831, DOI: 10.1097/00005344-200605001-00011.
- Sahota A, Shandil R, Barmaki A, Salama P, Simpson N, Laine L. Foreign Body Ingestions: Characteristics and Outcomes in a Lower Socioeconomic Population. Gastrointestinal Endoscopy 2006, 63: ab154. DOI: 10.1016/j.gie.2006.03.296.
- Goldkind L, Laine L. A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience. Pharmacoepidemiology And Drug Safety 2006, 15: 213-220. PMID: 16456879, DOI: 10.1002/pds.1207.
- Laine L, Planas R, Nevens F, Bañares R, Patch D, Bosch J. Session 5: Treatment of the Acute Bleeding Episode. 2006, 217-242. DOI: 10.1002/9780470988831.ch9.
- Nathwani RA, Suh J, Simpson N, Shaposhnikov R, Chang A, Laine L. Foreign body “bezoar”. Gastrointestinal Endoscopy 2006, 63: 150. PMID: 16377334, DOI: 10.1016/j.gie.2005.04.009.
- Laine LA, Nathwani RA, Naritoku W. The effect of GI bleeding on Helicobacter pylori diagnostic testing: a prospective study at the time of bleeding and 1 month later. Gastrointestinal Endoscopy 2005, 62: 853-859. PMID: 16301025, DOI: 10.1016/j.gie.2005.09.019.
- Rao S, Ozturk R, Laine L. Clinical Utility of Diagnostic Tests for Constipation in Adults: A Systematic Review. The American Journal Of Gastroenterology 2005, 100: ajg2005283. PMID: 15984989, DOI: 10.1111/j.1572-0241.2005.41845.x.
- McQuaid KR, Laine L. Early Heartburn Relief With Proton Pump Inhibitors: A Systematic Review and Meta-analysis of Clinical Trials. Clinical Gastroenterology And Hepatology 2005, 3: 553-563. PMID: 15952097, DOI: 10.1016/s1542-3565(05)00023-6.
- Rostom A, Goldkind L, Laine L. Nonsteroidal Anti-Inflammatory Drugs and Hepatic Toxicity: A Systematic Review of Randomized Controlled Trials in Arthritis Patients. Clinical Gastroenterology And Hepatology 2005, 3: 489-498. PMID: 15880319, DOI: 10.1016/s1542-3565(04)00777-3.
- Conrad SA, Gabrielli A, Margolis B, Quartin A, Hata JS, Frank WO, Bagin RG, Rock JA, Hepburn B, Laine L. Randomized, double-blind comparison of immediate-release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal bleeding in critically ill patients. Critical Care Medicine 2005, 33: 760-765. PMID: 15818102, DOI: 10.1097/01.ccm.0000157751.92249.32.
- Gastroinestinal BleedingLaine L. Gastrointestinal Bleeding. In Harrison’s Principles of Internal Medicine, 16th Edition. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, Eds. The McGraw-Hill Companies, Inc. 2005; pp. 235-8.
- Laine L, Maller ES, Yu C, Quan H, Simon T. Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: A double-blind trial. Gastroenterology 2004, 127: 395-402. PMID: 15300570, DOI: 10.1053/j.gastro.2004.05.001.
- Rubenstein JH, Laine L. The hepatotoxicity of non‐steroidal anti‐inflammatory drugs. Alimentary Pharmacology & Therapeutics 2004, 20: 373-380. PMID: 15298630, DOI: 10.1111/j.1365-2036.2004.02092.x.
- Laine L. Treatment of Nonvariceal Upper GI Hemorrhage: What's Happening in the Real World. The American Journal Of Gastroenterology 2004, 99: ajg2004246. PMID: 15233661, DOI: 10.1111/j.1572-0241.2004.40252.x.
- Ofman JJ, Badamgarav E, Henning JM, Knight K, Laine L. Utilization of nonsteroidal anti-inflammatory drugs and antisecretory agents: a managed care claims analysis. The American Journal Of Medicine 2004, 116: 835-842. PMID: 15178499, DOI: 10.1016/j.amjmed.2004.02.028.
- Higgins PD, Davis KJ, Laine L. The epidemiology of ischaemic colitis. Alimentary Pharmacology & Therapeutics 2004, 19: 729-738. PMID: 15043513, DOI: 10.1111/j.1365-2036.2004.01903.x.
- Laine L. BLEEDING ULCERS WITH VISIBLE VESSELS OR CLOTS: IS IV PPI THERAPY ENOUGH? Evidence-Based Gastroenterology 2004, 5: 6-7. DOI: 10.1097/00132579-200402000-00003.
- Dubois RW, Melmed GY, Henning JM, Laine L. Guidelines for the appropriate use of non‐steroidal anti‐inflammatory drugs, cyclo‐oxygenase‐2‐specific inhibitors and proton pump inhibitors in patients requiring chronic anti‐inflammatory therapy. Alimentary Pharmacology & Therapeutics 2004, 19: 197-208. PMID: 14723611, DOI: 10.1111/j.0269-2813.2004.01834.x.
- Laine L. Proton pump inhibitor co-therapy with nonsteroidal anti-inflammatory drugs--nice or necessary? Gastroenterological Disorders 2004, 4 Suppl 4: s33-41. PMID: 15580145.
- Yang R, Zinn S, Maceri D, Laine L. Oro-pharyngeal biopsy: a new technique for gastroeternologists to evaluate patients with gastroesophageal reflux disease (GERD). The American Journal Of Gastroenterology 2003, 98: s293. DOI: 10.1111/j.1572-0241.2003.08620.x.
- Laine L. Coxibs were not cost-effective for arthritis pain in patients with average risk for ulcer complications. Annals Of Internal Medicine 2003, 139: 53. PMID: 12954045, DOI: 10.7326/acpjc-2003-139-2-053.
- Laine L, Wogen J, Yu H. Gastrointestinal health care resource utilization with chronic use of COX-2-specific inhibitors versus traditional NSAIDs1 1The Institute for Effectiveness Research, LLC, is a subsidiary of Medco Health Solutions, Inc., a Merck Company. Gastroenterology 2003, 125: 389-395. PMID: 12891540, DOI: 10.1016/s0016-5085(03)00900-4.
- Hawkey C, Laine L, Simon T, Quan H, Shingo S, Evans J. Incidence of gastroduodenal ulcers in patients with rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or placebo. European Journal Of Gastroenterology & Hepatology 2003, 15: 835. DOI: 10.1097/00042737-200307000-00021.
- Laine L. Celecoxib was as effective as diclofenac plus omeprazole in reducing recurrent ulcer bleeding in arthritis. Annals Of Internal Medicine 2003, 139: 12. PMID: 12841716, DOI: 10.7326/acpjc-2003-139-1-012.
- Hawkey CJ, Laine L, Simon T, Quan H, Shingo S, Evans J. Incidence of gastroduodenal ulcers in patients with rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or placebo: a multicentre, randomised, double blind study. Gut 2003, 52: 820. PMID: 12740337, PMCID: PMC1773685, DOI: 10.1136/gut.52.6.820.
- Laine L. Evidence-based medicine: clinical judgment is required. Gastroenterology 2003, 124: 1726. PMID: 12806603, DOI: 10.1016/s0016-5085(03)00546-8.
- Ofman J, Knight K, Badamgarav E, Henning J, Wallace K, Wong J, Dylan M, Laine L. Proton pump inhibitor use in patients with indications for low-dose aspirin who start COX-2 selective inhibitors or nonselective NSAIDs. Gastroenterology 2003, 124: a107. DOI: 10.1016/s0016-5085(03)80529-2.
- Ofman J, Badamgarav E, Knight K, Henning J, Wallce K, Wong J, Dylan M, Laine L. Non-selective NSAIDs and COX-2 selective inhibitors: GI risk and use of proton pump inhibitor prophylaxis. Gastroenterology 2003, 124: a107. DOI: 10.1016/s0016-5085(03)80528-0.
- Laine L, Von Allmen H, Henderson S. GI healthcare resource use in 6009 patients switching from chronic NSAID to COX-2 specific inhibitor therapy and the effect of prior PPI use. Gastroenterology 2003, 124: a108. DOI: 10.1016/s0016-5085(03)80531-0.
- Laine L, Goldstein J, Fort J. Do NSAIDs induce esophagitis? The effect of non-specific NSAIDs and COX-2 specific inhibitors±low-dose aspirin in prospective, randomized, double-blind, placebo-controlled endoscopic trials. Gastroenterology 2003, 124: a511. DOI: 10.1016/s0016-5085(03)82586-6.
- Laine L, Hunt R, El-Zimaity H, Nguyen B, Osato M, Spénard J. Bismuth-Based Quadruple Therapy Using a Single Capsule of Bismuth Biskalcitrate, Metronidazole, and Tetracycline Given With Omeprazole Versus Omeprazole, Amoxicillin, and Clarithromycin for Eradication of Helicobacter pylori in Duodenal Ulcer Patients: A Prospective, Randomized, Multicenter, North American Trial. The American Journal Of Gastroenterology 2003, 98: ajg2003137. PMID: 12650788, DOI: 10.1111/j.1572-0241.2003.t01-1-07288.x.
- Laine L. Is it time for quadruple therapy to be first line? 2003, 347-351. DOI: 10.1007/978-94-017-1763-2_36.
- Laine L. Helicobacter pylori eradication does not benefit non-ulcer dyspepsia. 2003, 275-281. DOI: 10.1007/978-94-017-1763-2_28.
- Sugg J, Laine L. Effect of Helicobacter pylori eradication on development of erosive esophagitis and gastroesophageal reflux disease symptoms: a post hoc analysis of eight double blind prospective studies. The American Journal Of Gastroenterology 2002, 97: 2992. PMID: 12492181, DOI: 10.1111/j.1572-0241.2002.07116.x.
- Laine L, Bombardier C, Hawkey CJ, Davis B, Shapiro D, Brett C, Reicin A. Stratifying the risk of NSAID-related upper gastrointestinal clinical events: Results of a double-blind outcomes study in patients with rheumatoid arthritis. Gastroenterology 2002, 123: 1006-1012. PMID: 12360461, DOI: 10.1053/gast.2002.36013.
- Laine L. Management of ulcers with adherent clots. Gastroenterology 2002, 123: 632-636. PMID: 12145815, DOI: 10.1053/gast.2002.35133.
- Laine L, Dhir V. Helicobacter pylori eradication does not worsen quality of life related to reflux symptoms: a prospective trial. Alimentary Pharmacology & Therapeutics 2002, 16: 1143-1148. PMID: 12030957, DOI: 10.1046/j.1365-2036.2002.01267.x.
- Laine L, Fennerty M, Schoenfeld P. Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia. Annals Of Internal Medicine 2002, 136: 556. DOI: 10.7326/0003-4819-136-7-200204020-00019.
- Helicobacter pylori eradication does not benefit non-ulcer dyspepsia.Laine L. Helicobacter pylori eradication does not benefit non-ulcer dyspepsia. Helicobacter pylori: Basic Mechanisms to Clinical Cure 2002. Hunt RH, Tytgat GNJ, Eds. Kluwer Academic Publishers. 2002; pp.275-81.
- Is it time for quadruple therapy to be first line?Laine L. Is it time for quadruple therapy to be first line? Helicobacter pylori: Basic Mechanisms to Clinical Cure 2002. Hunt RH, Tytgat GNJ, Eds. Kluwer Academic Publishers. 2002; pp.347-51.
- Laine L, Estrada R. Randomized trial of normal saline solution injection versus bipolar electrocoagulation for treatment of patients with high-risk bleeding ulcers: Is local tamponade enough? Gastrointestinal Endoscopy 2002, 55: 6-10. PMID: 11756906, DOI: 10.1067/mge.2002.120390.
- Laine L. Omeprazole was better than H. pylori eradication for preventing recurrent GI bleeding in patients receiving naproxen. Annals Of Internal Medicine 2001, 135: 92. DOI: 10.7326/acpjc-2001-135-3-092.
- Laine L. Review: Octreotide reduces rebleeding more than does vasopressin or terlipressin in patients with esophageal varices. Annals Of Internal Medicine 2001, 135: 51. DOI: 10.7326/acpjc-2001-135-2-051.
- Laine L. Reply–potential gastrointestinal effects of longterm acid suppression with proton pump inhibitors. Alimentary Pharmacology & Therapeutics 2001, 15: 1085-1086. DOI: 10.1046/j.1365-2036.2001.0994b.x.
- Wallace J, Ofman J, Enkhe B, Chiou C, Henning J, Laine L. The cost-effectiveness of competing strategies for the preventionol recurrent ulcer-related hemorrhage. Gastroenterology 2001, 120: a403. DOI: 10.1016/s0016-5085(08)82004-5.
- Laine L, Hawkey C, Bombardier C, Shapiro D, Reicin A. Stratilying the risk of clinical upper Gl events in NSAID users: Results from a double-blind outcomes study. Gastroenterology 2001, 120: a105. DOI: 10.1016/s0016-5085(08)80513-6.
- Laine L, Hunt R, El-Zimaity H, Osato M, Spenard J, Pharma A. Morth American randomized trial of single-triple capsule (bismuth subcitrate, metronidazele, tetracycline) plus omeprazole vs. Omeprazole, amoxicillin, and clarithremycin for H. pylori eradication. Gastroenterology 2001, 120: a580. DOI: 10.1016/s0016-5085(08)82885-5.
- LAINE L, HAWKEY C, BOMBARDIER C, SHAPIRO D, REICIN A. Stratilying the risk of clinical upper Gl events in NSAID users: Results from a double-blind outcomes study. Gastroenterology 2001, 120: a105-a105. DOI: 10.1016/s0016-5085(01)80513-8.
- WALLACE J, OFMAN J, ENKHE B, CHIOU C, HENNING J, LAINE L. The cost-effectiveness of competing strategies for the preventionol recurrent ulcer-related hemorrhage. Gastroenterology 2001, 120: a403-a403. DOI: 10.1016/s0016-5085(01)82004-7.
- Laine L, Schoenfeld P, Fennerty M. Therapy for Helicobacter pylori in patients with nonulcer dyspepsia. A meta-analysis of randomized, controlled trials. Annals Of Internal Medicine 2001, 134: 361-9. PMID: 11242496, DOI: 10.7326/0003-4819-134-5-200103060-00008.
- Laine L. Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient. Gastroenterology 2001, 120: 594-606. PMID: 11179238, DOI: 10.1053/gast.2001.21907.
- Burroughs A, Bosch J, Garcia‐Tsao G, Henderson J, Laine L, Nevens F, Riggio O. Session 1 ‒ Definition of Key Events: Lets's Try Again. 2001, 13-21. DOI: 10.1002/9780470760154.ch2.
- Laine L, Burroughs A, Silvain C, Vinel J, Bosch J. Session 6 ‒ Treatment of the Acute Bleeding Episode. 2001, 134-169. DOI: 10.1002/9780470760154.ch10.
- Gastroinestinal BleedingLaine L. Gastrointestinal Bleeding. In Harrison’s Principles of Internal Medicine, 15th Edition. Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, Eds. The McGraw-Hill Companies, Inc. 2001; pp. 252-4.
- Laine L, Fennerty M, Osato M, Sugg J, Suchower L, Probst P, Levine J. Esomeprazole-based Helicobacter pylori eradication therapy and the effect of antibiotic resistance: results of three US multicenter, double-blind trials. The American Journal Of Gastroenterology 2000, 95: ajg20001583. PMID: 11151867, DOI: 10.1111/j.1572-0241.2000.03349.x.
- LAINE L. FOREWORD. Gastroenterology Clinics Of North America 2000, 29: 13-14. DOI: 10.1016/s0889-8553(05)70142-4.
- Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, Day R, Ferraz M, Hawkey C, Hochberg M, Kvien T, Schnitzer T. Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis. New England Journal Of Medicine 2000, 343: 1520-1528. PMID: 11087881, DOI: 10.1056/nejm200011233432103.
- LAINE L. FOREWORD. Gastroenterology Clinics Of North America 2000, 29: 11a. DOI: 10.1016/s0889-8553(05)70128-x.
- Laine L, Bombardier C, Reicin A, Hawkey C, Watson D, Ramey D, Brett C. Gastrointestinal (GI) co-therapy, procedures, and hospitalizations in a GI outcomes study of rofecoxib vs. naproxen in rheumatoid arthritis. The American Journal Of Gastroenterology 2000, 95: 2633. DOI: 10.1111/j.1572-0241.2000.03124.x.
- Laine L, Sugg J, Suchower L, Neil G. Endoscopic biopsy requirements for post-treatment diagnosis of Helicobacter pylori. Gastrointestinal Endoscopy 2000, 51: 664-669. PMID: 10840297, DOI: 10.1067/mge.2000.105776.
- Laine, Ahnen, Mcclain, Solcia, Walsh. Review article: potential gastrointestinal effects of long‐term acid suppression with proton pump inhibitors. Alimentary Pharmacology & Therapeutics 2000, 14: 651-668. PMID: 10848649, DOI: 10.1046/j.1365-2036.2000.00768.x.
- Balfe D, Ralls P, Bree R, DiSantis D, Glick S, Levine M, Megibow A, Saini S, Shuman W, Greene F, Laine L, Lillemoe K, Kidd R. Imaging strategies in the initial evaluation of the jaundiced patient. American College of Radiology. ACR Appropriateness Criteria. Radiology 2000, 215 Suppl: 125-33. PMID: 11037417.
- Laine L, Schoenfeld P, Fennerty M. H. pylori therapy is not effective for treatment of non-ulcer dyspepsia: Meta-analysis of randomized controlled trials. Gastroenterology 2000, 118: a440. DOI: 10.1016/s0016-5085(00)83874-3.
- Laine L, Fennerty M, Suchower L, Probst P, Osato M, Levine J. H. pylori antibiotic resistance, eradication, and emergent resistance in U.S. double-blind trials of esomeprazole, clarithromycin, and amoxicillin. Gastroenterology 2000, 118: a498. DOI: 10.1016/s0016-5085(00)84113-x.
- Laine L, Sugg J, Probst P, Malone T, Neil G. Prevalence of active duodenal ulcer in H. pylori-positive patients with past history of duodenal ulcer and relationship to symptoms. Gastroenterology 2000, 118: a1264. DOI: 10.1016/s0016-5085(00)80899-9.
- Fennerty M, Laine L, Sugg J, Zuckerman S, Levine J. Esomeprazole based triple therapy is more effective than dual therapy for eradication of H pylori. Gastroenterology 2000, 118: a495. DOI: 10.1016/s0016-5085(00)84102-5.
- Laine L, Bombardier C, Hawkey C, Shapiro D, Reicin A. Influence of H. pylori and other potential risk factors on clinical gi events in a double-blind outcome study of rofecoxib VS. Naproxen. Gastroenterology 2000, 118: a862. DOI: 10.1016/s0016-5085(00)85588-2.
- Yang R, Ng S, Nichol M, Laine L. A cost and performance evaluation of disposable and reusable biopsy forceps in GI endoscopy. Gastrointestinal Endoscopy 2000, 51: 266-270. PMID: 10699769, DOI: 10.1016/s0016-5107(00)70353-1.
- Laine L. Reply. Gastroenterology 2000, 118: 641. DOI: 10.1016/s0016-5085(00)70282-4.
- Hawkey C, Laine L, Simon T, Beaulieu A, Maldonado‐Cocco J, Acevedo E, Shahane A, Quan H, Bolognese J, Mortensen E. Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: A randomized, double‐blind, placebo‐controlled trial. Arthritis & Rheumatism 2000, 43: 370-377. PMID: 10693877, DOI: 10.1002/1529-0131(200002)43:2<370::aid-anr17>3.0.co;2-d.
- Helicobacter pylori and nonulcer dyspepsiaCohen H, Laine L. Helicobacter pylori and nonulcer dyspepsia. In Dyspepsia. Johnson DA, Katz PO, Castell DO, Eds. American College of Physicians. Philadelphia, PA. 2000; pp 63-77.
- How to explain outcome differences in dyspepsia studiesFennerty MB, Laine LA. How to explain outcome differences in dyspepsia studies. Helicobacter pylori: Basic Mechanisms to Clinical Cure 2000. Hunt RH, Tytgat GNJ, Eds. Kluwer Academic Publishers. 2000; pp. 421-5.
- Fennerty M, Laine L. How to explain outcome differences in dyspepsia studies. 2000, 421-425. DOI: 10.1007/978-94-011-3927-4_44.
- Faigel D, Vartan G, Knigge K, Laine L, Fennerty M, Margaret N, Marquis S. Fingerstick Helicobacter pylori antibody test: better than laboratory serological testing? The American Journal Of Gastroenterology 1999, 94: ajg1999810. PMID: 10606304, DOI: 10.1111/j.1572-0241.1999.01510.x.
- Schoenfeld, Kimmey, Scheiman, Bjorkman, Laine. Review article: nonsteroidal anti‐inflammatory drug‐associated gastrointestinal complications—guidelines for prevention and treatment. Alimentary Pharmacology & Therapeutics 1999, 13: 1273-1285. PMID: 10540041, DOI: 10.1046/j.1365-2036.1999.00617.x.
- Laine L, Harper S, Simon T, Bath R, Johanson J, Schwartz H, Stern S, Quan H, Bolognese J, Group F. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2–specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis. Gastroenterology 1999, 117: 776-783. PMID: 10500058, DOI: 10.1016/s0016-5085(99)70334-3.
- Laine L. Management of Acute Colonic Pseudo-Obstruction. New England Journal Of Medicine 1999, 341: 192-193. PMID: 10403858, DOI: 10.1056/nejm199907153410309.
- Cave DR, van Zanten S, Carter E, Halpern EF, Klein S, Prather C, Stolte M, Laine L. A multicentre evaluation of the laser assisted ratio analyser (LARA): a novel device for measurement of 13CO2 in the 13C‐urea breath test for the detection of Helicobacter pylori infection. Alimentary Pharmacology & Therapeutics 1999, 13: 747-752. PMID: 10383503, DOI: 10.1046/j.1365-2036.1999.00534.x.
- Schoenfeld* P, Guyatt‡ G, Hamilton§ F, Laine∥ L, Cook‡ D, Bjorkman¶ D, Morgan# D, Peterson** W, Group F. An evidence-based approach to gastroenterology diagnosis. Gastroenterology 1999, 116: 1230-1237. PMID: 10220515, DOI: 10.1016/s0016-5085(99)70026-0.
- Laine L, Estrada R, Trujillo M, Cheybani K, Yeramian P, Smith S, Neil G. Once-daily therapy for H. pylori infection: a randomized comparison of four regimens. The American Journal Of Gastroenterology 1999, 94: 962. PMID: 10201465, DOI: 10.1111/j.1572-0241.1999.995_r.x.
- Laine L, Cohen H. Helicobacter pylori: drowning in a pool of blood? Gastrointestinal Endoscopy 1999, 49: 398-402. PMID: 10049431, DOI: 10.1016/s0016-5107(99)70024-6.
- Acid Peptic DisordersDel Valle J, Cohen H, Laine L, Scheiman J. Acid Peptic Disorders. In Textbook of Gastroenterology, 3rd Edition. Yamada T, Alpers DH, Laine L, Owyang C, Powell D, Eds. Lippincott Williams & Wilkins. 1999; pp. 1370-1444.
- Laine L, Suchower L, Frantz J, Connors A, Neil G. Twice-daily, 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in duodenal ulcer disease: results of three multicenter, double-blind, United States trials. The American Journal Of Gastroenterology 1998, 93: ajg1998488. PMID: 9820381, DOI: 10.1111/j.1572-0241.1998.00602.x.
- Sadowski D, Cohen H, Laine L, Greenberg P, Goldstein J, Mihalov M, Cutler A. Evaluation of the FlexSure HP whole blood antibody test for diagnosis of Helicobacter pylori infection. The American Journal Of Gastroenterology 1998, 93: ajg1998490. PMID: 9820383, DOI: 10.1111/j.1572-0241.1998.00604.x.
- Bonacini M, Laine L. Esophageal Disease in Patients with AIDS: Diagnosis and Treatment. Gastrointestinal Endoscopy Clinics Of North America 1998, 8: 811-823. PMID: 9730933, DOI: 10.1016/s1052-5157(18)30233-2.
- Laine L, Estrada R, Trujillo M, Knigge K, Fennerty MB. Effect of proton-pump inhibitor therapy on diagnostic testing for Helicobacter pylori. Annals Of Internal Medicine 1998, 129: 547-50. PMID: 9758575, DOI: 10.7326/0003-4819-129-7-199810010-00007.
- Laine L, Hopkins R, Girardi L. Has the impact of helicobacter pylori therapy on ulcer recurrence in the united states been overstated? The American Journal Of Gastroenterology 1998, 93: 1409. PMID: 9732917, DOI: 10.1111/j.1572-0241.1998.452_a.x.
- Laine L. Has the impact of helicobacter pylori therapy on ulcer recurrence in the united states been overstated? A meta-analysis of rigorously designed trials. The American Journal Of Gastroenterology 1998, 93: 1409-1415. DOI: 10.1016/s0002-9270(98)00333-5.
- Schoenfeld P, Cook D, Hamilton F, Laine L, Morgan D, Peterson W, Group F. An evidence-based approach to gastroenterology therapy. Gastroenterology 1998, 114: 1318-1325. PMID: 9609770, DOI: 10.1016/s0016-5085(98)70439-1.
- Laine, Johnson, Suchower, Ronca, Hwang, Neil. US double‐blind, controlled trials of omeprazole and amoxycillin for treatment of Helicobacter pylori. Alimentary Pharmacology & Therapeutics 1998, 12: 377-382. PMID: 9690729, DOI: 10.1046/j.1365-2036.1998.00303.x.
- Chey W, Murthy U, Toskes P, Carpenter S, Laine L. Validation of the 13C-urea blood test for H. Pylori infection: A US, multicenter trial. Gastroenterology 1998, 114: a91. DOI: 10.1016/s0016-5085(98)80368-5.
- Laine L, Estrada R, Trujillo M, Cheybani K, Yeramian, Smith S, Nei G. Once-daily therapy for H. pylori: A randomized comparison of four regimens. Gastroenterology 1998, 114: a192-a193. DOI: 10.1016/s0016-5085(98)80784-1.
- Knigge K, Fennerty M, Faigel D, Magaret N, Marquis S, Vartan G, Laine L. An office-based whole blood test is preferable to a laboratory quantitative serology test in the determination of Helicobacter pylori infection documented by endoscopic biopsy. Gastroenterology 1998, 114: a180. DOI: 10.1016/s0016-5085(98)80731-2.
- Laine L, Suchower L, Connors A, Frantz J, Neil G. Twice-daily 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for H. Pylori eradication in duodenal ulcer disease: Results of 3 multicenter, double-blind, U.S. Trials. Gastroenterology 1998, 114: a193. DOI: 10.1016/s0016-5085(98)80787-7.
- Laine L, Suchower L, Connors A, Frantz J, Neil G. Reduced risk of clarithromycin-resistant H. pylori with amoxicillin cotherapy: Results from 3 multicenter double-blind U.S. trials. Gastroenterology 1998, 114: a193. DOI: 10.1016/s0016-5085(98)80786-5.
- Yang R, Hamamoto R, Laine L. 1-week Vs. 2-week bismuth subsalicylate-based triple therapy for H. Pylori: Results of a U.S. randomized trial. Gastroenterology 1998, 114: a340. DOI: 10.1016/s0016-5085(98)81378-4.
- Laine L, Estrada R, Trujillo M, Knigge C, Fennerty M. Prospective evaluation of the effect of proton pump inhibitor therapy on H. Pylori diagnostic testing. Gastroenterology 1998, 114: a193. DOI: 10.1016/s0016-5085(98)80785-3.
- Laine L, Fendrick A. Helicobacter pylori and peptic ulcer disease. Postgraduate Medicine 1998, 103: 231-243. PMID: 9519040, DOI: 10.3810/pgm.1998.03.423.
- Laine L, Suchower L, Johnson E, Ronca P, Neil G. Accuracy of CLOtest after Helicobacter pylori therapy. Gastrointestinal Endoscopy 1998, 47: 250-253. PMID: 9540877, DOI: 10.1016/s0016-5107(98)70321-9.
- Laine L, Sidhom O, Emami S, Estrada R, Cohen H. Effect of blood on rapid urease testing of gastric mucosal biopsy specimens. Gastrointestinal Endoscopy 1998, 47: 141-143. PMID: 9512278, DOI: 10.1016/s0016-5107(98)70346-3.
- Laine L. Management of actively bleeding esophageal varices. Gastrointestinal Endoscopy 1997, 46: 83-84. PMID: 9260714, DOI: 10.1016/s0016-5107(97)70218-9.
- Laine L, Lewin D, Naritoku W, Cohen H. Prospective comparison of H&E, Giemsa, and Genta stains for the diagnosis of Helicobacter pylori. Gastrointestinal Endoscopy 1997, 45: 463-467. PMID: 9199901, DOI: 10.1016/s0016-5107(97)70174-3.
- Crookes P, Leichman C, Leichman L, Tan M, Laine L, Stain S, Baranda J, Casagrande Y, Groshen S, Silberman H. Systemic chemotherapy for gastric carcinoma followed by postoperative intraperitoneal therapy. Cancer 1997, 79: 1767-1775. PMID: 9128994, DOI: 10.1002/(sici)1097-0142(19970501)79:9<1767::aid-cncr19>3.0.co;2-w.
- LAINE L. Introduction. Alimentary Pharmacology & Therapeutics 1997, 11: 1-1. DOI: 10.1046/j.1365-2036.11.s1.8.x.
- Laine L, Stein C, Estrada R. Randomized comparison of saline injection vs. Bipolar electrocoagulation (BPEC) for treatment of patients with high-risk bleeding ulcers. Gastrointestinal Endoscopy 1997, 45: ab94. DOI: 10.1016/s0016-5107(97)80281-7.
- Yang R, Ng S, Nichol M, Laine L. Disposable versus reusable biopsy forceps: A prospective cost and performance evaluation. Gastrointestinal Endoscopy 1997, 45: ab58. DOI: 10.1016/s0016-5107(97)80136-8.
- Gastroinestinal BleedingLaine L. Gastrointestinal bleeding. In Sleisenger and Fordtran’s Gastrointestinal Disease, 6th Edition. Feldman M, Scharschmidt B, Sleisenger MH, Eds. W.B. Saunders Co. 1997; pp. 198-219.
- Laine L, Lewin D, Naritoku W, Estrada R, Cohen H. Prospective comparison of commercially available rapid urease tests for the diagnosis of Helicobacter pylori. Gastrointestinal Endoscopy 1996, 44: 523-526. PMID: 8934155, DOI: 10.1016/s0016-5107(96)70002-0.
- Laine L, Estrada R, Lewin D, Cohen H. The influence of warming on rapid urease test results: a prospective evaluation. Gastrointestinal Endoscopy 1996, 44: 429-432. PMID: 8905363, DOI: 10.1016/s0016-5107(96)70094-9.
- Laine L. Nonsteroidal Anti-Inflammatory Drug Gastropathy. Gastrointestinal Endoscopy Clinics Of North America 1996, 6: 489-504. PMID: 8803564, DOI: 10.1016/s1052-5157(18)30351-9.
- Laine L. Helicobacter pylori and Complicated Ulcer Disease. The American Journal Of Medicine 1996, 100: 52s-59s. PMID: 8644783, DOI: 10.1016/s0002-9343(96)80229-4.
- Laine L. Octreotide after endoscopic variceal ligation reduced recurrent bleeding. Annals Of Internal Medicine 1996, 124: 66. DOI: 10.7326/acpjc-1996-124-3-066.
- Soll A, Achord J, Bozymski G, Brooks S, Lanza F, Lyon D, Meyer G, Reinus J, Schuster M, Achord J, Ofman J, Glassman P, Laine L, Tytgat G, Walsh J, Graham D, Peterson W. Medical Treatment of Peptic Ulcer Disease: Practice Guidelines. JAMA 1996, 275: 622-629. DOI: 10.1001/jama.1996.03530320046033.
- Laine L, Stein C, Sharma V. A prospective outcome study of patients with clot in an ulcer and the effect of irrigation. Gastrointestinal Endoscopy 1996, 43: 107-110. PMID: 8635701, DOI: 10.1016/s0016-5107(06)80109-4.
- Laine L, Stein C, Sharma V. Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices. Gastroenterology 1996, 110: 529-533. PMID: 8566601, DOI: 10.1053/gast.1996.v110.pm8566601.
- Laine L, Chun D, Stein C, El-Beblawi I, Sharma V, Chandrasoma P. The influence of size or number of biopsies on rapid urease test results: a prospective evaluation. Gastrointestinal Endoscopy 1996, 43: 49-53. PMID: 8903818, DOI: 10.1016/s0016-5107(96)70260-2.
- Laine L, Cohen H, Sloane R, Marin-Sorensen M, Weinstein W. Interobserver agreement and predictive value of endoscopic findings for H. pylori and gastritis in normal volunteers. Gastrointestinal Endoscopy 1995, 42: 420-423. PMID: 8566631, DOI: 10.1016/s0016-5107(95)70043-9.
- Laine L, Sloane R, Ferretti M, Cominelli F. A randomized, double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production. Gastrointestinal Endoscopy 1995, 42: 428-433. PMID: 8566633, DOI: 10.1016/s0016-5107(95)70045-5.
- Laine L, Cook D. Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis. Annals Of Internal Medicine 1995, 123: 280-7. PMID: 7611595, DOI: 10.7326/0003-4819-123-4-199508150-00007.
- Laine L. Ligation: Endoscopic treatment of choice for patients with bleeding esophageal varices? Hepatology 1995, 22: 663-665. PMID: 7635437, DOI: 10.1002/hep.1840220242.
- Laine L. Ligation: Endoscopic treatment of choice for patients with bleeding esophageal varices? Hepatology 1995, 22: 663-665. DOI: 10.1016/0270-9139(95)90594-4.
- Laine L, Chun D, Stein C, El-Beblawi I, Sharma V, Chandrasoma P. The influence of size or number of biopsies on rapid urease test results: A prospective evaluation. Gastroenterology 1995, 108: a142. DOI: 10.1016/0016-5085(95)23232-x.
- Yang R, Laine L. Randomized study of monopolar vs. bipolar polypectomy snares. Gastrointestinal Endoscopy 1995, 41: 315. DOI: 10.1016/s0016-5107(05)80116-6.
- Laine L, Stein C, Sharma V. Randomized comparison of ligation VS. Ligation plus sclerotherapy for esophageal variceal bleeding. Gastrointestinal Endoscopy 1995, 41: 353. DOI: 10.1016/s0016-5107(05)80268-8.
- Laine L, Stein C, Sharma V. A prospective outcome study of patients with clots in an ulcer and the effect of irrigation. Gastrointestinal Endoscopy 1995, 41: 368. DOI: 10.1016/s0016-5107(05)80325-6.
- Stein C, Laine L. Randomized comparison of normal saline injection vs. bipolar electrocoagulation in high-risk patients with bleeding ulcers. Gastrointestinal Endoscopy 1995, 41: 371. DOI: 10.1016/s0016-5107(05)80340-2.
- Yang R, Ha T, Roque J, Laine L. Randomized, prospective study of bipolar electrocoagulation (BPEC) vs. infrared coagulation (IRC) for bleeding internal hemorrhoids (IH). Gastrointestinal Endoscopy 1995, 41: 387. DOI: 10.1016/s0016-5107(05)80401-8.
- LAINE L, COMINELLI F, SLOANE R, CASINI‐RAGGI V, MARIN‐SORENSEN M, WEINSTEIN WM. Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: a controlled double‐blind trial. Alimentary Pharmacology & Therapeutics 1995, 9: 127-135. PMID: 7605852, DOI: 10.1111/j.1365-2036.1995.tb00361.x.
- Yang R, Laine L. Mucosal stripping: a complication of push enteroscopy. Gastrointestinal Endoscopy 1995, 41: 156-158. PMID: 7721006, DOI: 10.1016/s0016-5107(05)80601-7.
- Laine L. The long-term management of patients with bleeding ulcers: Helicobacter pylori eradication instead of maintenance antisecretory therapy. Gastrointestinal Endoscopy 1995, 41: 77-79. PMID: 7698632, DOI: 10.1016/s0016-5107(95)70283-0.
- Acid Peptic DisordersIsenberg J, McQuaid KR, Laine L, Walsh JH. Acid Peptic Disorders. In Textbook of Gastroenterology. Yamada T, Ed. J.B. Lippincott Co. 2nd Edition 1995;1347-1430.
- Yang R, Naritoku W, Laine L. Prospective, randomized comparison of disposable and reusable biopsy forceps in gastrointestinal endoscopy. Gastrointestinal Endoscopy 1994, 40: 671-674. PMID: 7859962, DOI: 10.1016/s0016-5107(94)70107-5.
- Laine L, Peterson W. Bleeding Peptic Ulcer. New England Journal Of Medicine 1994, 331: 717-727. PMID: 8058080, DOI: 10.1056/nejm199409153311107.
- Laine L. The natural history of esophageal candidiasis after successful treatment in patients with AIDS. Gastroenterology 1994, 107: 744-746. PMID: 8076760, DOI: 10.1016/0016-5085(94)90122-8.
- Laine L. Esophageal disease in human immunodeficiency virus infection. JAMA Internal Medicine 1994, 154: 1577-1582. DOI: 10.1001/archinte.154.14.1577.
- Laine L, Freeman M, Cohen H. Lack of uniformity in evaluation of endoscopic prognostic features of bleeding ulcers. Gastrointestinal Endoscopy 1994, 40: 411-417. PMID: 7926529, DOI: 10.1016/s0016-5107(94)70202-0.
- Techniques and results for control of gastrointestinal bleeding: bipolar/multi-polar electrocoagulation and heater probeLaine L. Techniques and results for control of gastrointestinal bleeding: bipolar/multi-polar electrocoagulation and heater probe. In: Barkin JS, O’Phelan CA (Eds). Advanced therapeutic endoscopy. 2nd Ed. New York: Raven Press 1994; pp. 119-23.
- Laine L, el-Newihi HM, Migikovsky B, Sloane R, Garcia F. Endoscopic ligation compared with sclerotherapy for the treatment of bleeding esophageal varices. Annals Of Internal Medicine 1993, 119: 1-7. PMID: 8498757, DOI: 10.7326/0003-4819-119-1-199307010-00001.
- Laine L, Garcia F, McGilligan K, Malinko A, Sinatra F, Thomas D. Protein-losing enteropathy and hypoalbuminemia in AIDS. AIDS 1993, 7: 837-840. PMID: 8363760, DOI: 10.1097/00002030-199306000-00012.
- Laine L. Cost-Effective Treatment of Candida Esophagitis. Annals Of Internal Medicine 1993, 118: 824-825. DOI: 10.7326/0003-4819-118-10-199305150-00016.
- Laine L. HELICOBACTER PYLORI, GASTRIC ULCER, AND AGENTS NOXIOUS TO THE GASTRIC MUCOSA. Gastroenterology Clinics Of North America 1993, 22: 117-125. PMID: 8449561, DOI: 10.1016/s0889-8553(21)00267-3.
- Laine L. Refining the prognostic value of endoscopy in patients presenting with bleeding ulcers. Gastrointestinal Endoscopy 1993, 39: 461-462. PMID: 8514088, DOI: 10.1016/s0016-5107(93)70132-7.
- Yang R, Migikovsky B, Peicher J, Laine L. Randomized, prospective trial of direct current versus bipolar electrocoagulation for bleeding internal hemorrhoids. Gastrointestinal Endoscopy 1993, 39: 766-769. PMID: 8293898, DOI: 10.1016/s0016-5107(93)70261-8.
- Gastrointestinal BleedingPeterson WL, Laine L. Gastrointestinal bleeding. In Gastrointestinal Disease, 5th Edition. Sleisenger MH, Fordtran JS, Ed. W.B. Saunders Company 1993; pp. 162-92.
- Laine L. Comment. Gastroenterology 1992, 103: 1980-1981. DOI: 10.1016/0016-5085(92)91462-d.
- Laine L, Dretler RH, Conteas CN, Tuazon C, Koster FM, Sattler F, Squires K, Islam MZ. Fluconazole compared with ketoconazole for the treatment of Candida esophagitis in AIDS. A randomized trial. Annals Of Internal Medicine 1992, 117: 655-60. PMID: 1308663, DOI: 10.7326/0003-4819-117-8-655.
- Laine L. A new double lumen, direct irrigation injection therapy catheter. Gastrointestinal Endoscopy 1992, 38: 594-595. PMID: 1397918, DOI: 10.1016/s0016-5107(92)70525-2.
- Laine L. Endoscopic injection reduced rebleeding in bleeding peptic ulcers. Annals Of Internal Medicine 1992, 117: 38. DOI: 10.7326/acpjc-1992-117-2-038.
- Laine L. Endoscopic injection reduced further bleeding and need for surgery in patients with bleeding duodenal ulcers. Annals Of Internal Medicine 1992, 117: 39. DOI: 10.7326/acpjc-1992-117-2-039.
- Cook D, Laine L. Indications, Technique, and Complications of Balloon Tamponade for Variceal Gastrointestinal Bleeding. Journal Of Intensive Care Medicine 1992, 7: 212-218. PMID: 10147943, DOI: 10.1177/088506669200700408.
- Cook D, Guyatt G, Salena B, Laine L. Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis. Gastroenterology 1992, 102: 139-148. PMID: 1530782, DOI: 10.1016/0016-5085(92)91793-4.
- Laine L, Cohen H, Brodhead J, Cantor D, Garcia F, Mosquera M. Prospective evaluation of immediate versus delayed refeeding and prognostic value of endoscopy in patients with upper gastrointestinal hemorrhage. Gastroenterology 1992, 102: 314-316. PMID: 1727765, DOI: 10.1016/0016-5085(92)91816-m.
- Acid Peptic DisordersMc Quaid KR, Laine L. Acid peptic disorders. In Atlas of Gastroenterology. Yamada T, (Ed.) J.B. Lippincott Company, 1992 pp. 164 -71.
- Endoscopic therapy of non-variceal bleeding: Bipolar/multipolar probe.Laine L. Endoscopic therapy of non-variceal bleeding: Bipolar/multipolar probe. In Gastrointestinal Bleeding. Schuman BM, Sugawa C, Lucas C, (Eds.) Igaku-Shoin Medical Publishers 1992 pp. 314-23.
- Laine L. Bipolar-Multipolar Electrocoagulation of Bleeding Ulcers. Gastrointestinal Endoscopy Clinics Of North America 1991, 1: 291-302. DOI: 10.1016/s1052-5157(18)30672-x.
- Bonacini M, Young T, Laine L. The Causes of Esophageal Symptoms in Human Immunodeficiency Virus Infection: A Prospective Study of 110 Patients. JAMA Internal Medicine 1991, 151: 1567-1572. DOI: 10.1001/archinte.1991.00400080067012.
- Bonacini M, Young T, Laine L. The causes of esophageal symptoms in human immunodeficiency virus infection. A prospective study of 110 patients. JAMA Internal Medicine 1991, 151: 1567-72. PMID: 1651690, DOI: 10.1001/archinte.151.8.1567.
- Cook D, Laine L, Guyatt G, Raffin T. Nosocomial Pneumonia and the Role of Gastric pH A Meta-Analysis. CHEST Journal 1991, 100: 7-13. PMID: 1676361, DOI: 10.1378/chest.100.1.7.
- Laine L. Determination of the optimal technique for bipolar electrocoagulation treatment An experimental evaluation of the BICAP and Gold probes. Gastroenterology 1991, 100: 107-112. PMID: 1983812, DOI: 10.1016/0016-5085(91)90589-d.
- Diseases of the stomach and duodenum: Helicobacter pylori, peptic ulcer diseases and gastritisIsenberg J, Mc Quaid KR, Laine L, Rubin W. Diseases of the stomach and duodenum: Helicobacter pylori, peptic ulcer diseases and gastritis. In Textbook of Gastroenterology. Yamada T, Ed. J.B. Lippincott Company. 1991 pp. 1241-98.
- Laine L. Multipolar electrocoagulation versus injection therapy in the treatment of bleeding peptic ulcers A prospective, randomized trial. Gastroenterology 1990, 99: 1303-1306. PMID: 2210238, DOI: 10.1016/0016-5085(90)91154-x.
- Silvain C, Fort E, Ingrand P, Beauchant M, Valenzuela J, Schubert T, Posillico J, Laine L. Acute variceal bleeding: Still searching for the right treatment. Hepatology 1990, 12: 625-626. PMID: 1976106, DOI: 10.1002/hep.1840120335.
- Laine L, Marin-Sorensen M, Weinstein W. Campylobacter pylori in alcoholic hemorrhagic “gastritis”. Digestive Diseases And Sciences 1989, 34: 677-680. PMID: 2785447, DOI: 10.1007/bf01540337.
- Laine L. Multipolar electrocoagulation in the treatment of peptic ulcers with nonbleeding visible vessels. A prospective, controlled trial. Annals Of Internal Medicine 1989, 110: 510-4. PMID: 2647014, DOI: 10.7326/0003-4819-110-7-510.
- Laine L. A prospective trial of an anti-splatter device for the protection of endoscopic personnel from potentially AIDS-infective fluids. Gastrointestinal Endoscopy 1988, 34: 470-471. PMID: 3234685, DOI: 10.1016/s0016-5107(88)71438-8.
- Pettross C, Appleman M, Cohen H, Valenzuela J, Chandrasoma P, Laine L. Prevalence ofCampylobacter pylori and association with antral mucosal histology in subjects with and without upper gastrointestinal symptoms. Digestive Diseases And Sciences 1988, 33: 649-653. PMID: 3371136, DOI: 10.1007/bf01540425.
- Laine L, Weinstein W. Histology of alcoholic hemorrhagic “gastritis”: A prospective evaluation. Gastroenterology 1988, 94: 1254-1262. PMID: 3258836, DOI: 10.1016/0016-5085(88)90661-0.
- Laine L, Weinstein W. Subepithelial hemorrhages and erosions of human stomach. Digestive Diseases And Sciences 1988, 33: 490-503. PMID: 3280275, DOI: 10.1007/bf01536037.
- Laine L, Bentley E, Chandrasoma P. Effect of oral iron therapy on the upper gastrointestinal tract. Digestive Diseases And Sciences 1988, 33: 172-177. PMID: 3257437, DOI: 10.1007/bf01535729.
- Laine L. Multipolar Electrocoagulation in the Treatment of Active Upper Gastrointestinal Tract Hemorrhage. New England Journal Of Medicine 1987, 316: 1613-1617. PMID: 3295547, DOI: 10.1056/nejm198706253162601.
- Laine L, Politoske EJ, Gill P. Protein-Losing Enteropathy in Acquired Immunodeficiency Syndrome due to Intestinal Kaposi's Sarcoma. JAMA Internal Medicine 1987, 147: 1174-1175. PMID: 3592885, DOI: 10.1001/archinte.1987.00370060170028.
- Laine L. Protein-losing enteropathy in acquired immunodeficiency syndrome due to intestinal Kaposi's sarcoma. JAMA Internal Medicine 1987, 147: 1174-1175. DOI: 10.1001/archinte.147.6.1174.
- Laine L, Holt K. Recurrent Pericarditis and Celiac Disease. JAMA 1984, 252: 3168-3168. PMID: 6502887, DOI: 10.1001/jama.1984.03350220074036.
- Laine L. Recurrent pericarditis and celiac disease. JAMA 1984, 252: 3168-3168. DOI: 10.1001/jama.252.22.3168.
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