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Jon Koff, MD

Pulmonology & Sleep Medicine, Pulmonary Critical Care
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Patient type treated
Accepting new patients
Referral required
From patients or physicians
Board Certified in
Pulmonary Disease and Critical Care Medicine (Internal Medicine)


Jonathan Koff, MD, a pulmonary and critical care physician, is director of the Yale Medicine Adult Cystic Fibrosis Program. He chose pulmonary medicine in part because his grandfather had emphysema. “I wanted to better understand how the disease affected him,” he says.

Dr. Koff was drawn to cystic fibrosis, which is usually diagnosed in childhood, because he was intrigued by the complexity of this genetic disease, which causes recurrent lung infections, and digestive and nutritional problems, among other issues. He works with a multidisciplinary team that includes a nurse, a nutritionist, a physical therapist, a social worker, and respiratory therapists. “We continue to see our patients do better clinically with the multidisciplinary team-based care approach,” he says. He is optimistic about new treatments for cystic fibrosis, such as recently approved therapies that target specific genetic mutations.

An associate professor of medicine (pulmonary) at Yale School of Medicine, Dr. Koff also works in the medical intensive care unit at Yale New Haven Hospital, and conducts laboratory and translational research that focuses on viral infections in asthma and cystic fibrosis. He serves on the board of the Connecticut Chapter of the Cystic Fibrosis Foundation. 


  • Associate Professor Term
  • Associate Director, Fellowship Research, Pulmonary, Critical Care & Sleep Medicine
  • Director, Adult Cystic Fibrosis Program

Education & Training

  • Fellowship
    University of California - San Francisco (2008)
  • Fellowship
    University of California - San Francisco (2008)
  • MD
    Case Western Reserve University School of Medicine (2000)
  • BA
    Hamilton College, World Politics

Languages Spoken

  • English
  • Spanish

Additional Information

  • Winchester Center for Lung Disease
    Fitkin Memorial Pavilion
    789 Howard Avenue, Ste 2nd Floor
    New Haven, CT, 06519
  • Yale Pulmonary & Critical Care Medicine
    Yale New Haven Hospital
    20 York Street
    New Haven, CT, 06510