Albert Ko, MD

Infectious Diseases

Click here to view more about this specialist's research and educational efforts on https://ysph.yale.edu

Click here to view more about this specialist's research and educational efforts onhttps://ysph.yale.edu

Biography

Dr. Albert Icksang Ko is the Raj and Indra Nooyi Professor of Public Health at the Yale School of Public Health and a Collaborating Researcher at the Oswaldo Cruz Foundation, Brazilian Ministry of Health. His research centers on the health problems that have emerged as a consequence of rapid urbanization and social inequity. Dr. Ko coordinates a research program in Brazil, which focuses on delineating the role of social marginalization, urban ecology and climate in the emergence of infectious disease threats in slum communities and informal settlements. He and his team have mobilized research capacity to develop and implement community-based interventions to epidemics of meningitis, leptospirosis, dengue, Zika virus infection and associated birth defects, and the current COVID-19 pandemic. Dr. Ko is also Program Director of the Fogarty/NIH Global Health Equity Scholars Program which provides research training opportunities for US and LMIC post and pre-doctoral fellows at collaborating international sites. He is a member of the WHO R&D Taskforce for Zika Virus and R&D Blueprint Working Group. During the pandemic, he served with Indra Nooyi as co-chair of Governor Lamont’s Reopen Connecticut Advisory Group. Dr. Ko continues to advise the Governor and the State on its pandemic prevention and control plan, in addition to supporting the Oswaldo Cruz Foundation in its COVID-19 response in Brazil.

Titles

Raj and Indra Nooyi Professor of Public Health and Professor of Epidemiology (Microbial Diseases) and of Medicine (Infectious Diseases)
Affiliated Faculty, Yale Institute for Global Health

Education & Training

Postdoctoral Fellow
Weill Medical College of Cornell University (1997)
Infectious Disease Fellow
Massachusetts General Hospital (1997)
Resident
Brigham and Women's Hospital (1994)
MD
Harvard Medical School (1991)
BS
Massachusetts Institute of Technology (1981)

Languages Spoken

English
Português (Portuguese)

Additional Information

Honors & Recognitions

Professional Service

Publications

Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group.
Ko AI, Galvão Reis M, Ribeiro Dourado CM, Johnson WD, Riley LW. Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group. Lancet 1999, 354: 820-5. PMID: 10485724, DOI: 10.1016/s0140-6736(99)80012-9.
Impact of environment and social gradient on Leptospira infection in urban slums.
Reis RB, Ribeiro GS, Felzemburgh RD, Santana FS, Mohr S, Melendez AX, Queiroz A, Santos AC, Ravines RR, Tassinari WS, Carvalho MS, Reis MG, Ko AI. Impact of environment and social gradient on Leptospira infection in urban slums. PLoS Neglected Tropical Diseases 2008, 2: e228. PMID: 18431445, PMCID: PMC2292260, DOI: 10.1371/journal.pntd.0000228.
Leptospirosis-associated severe pulmonary hemorrhagic syndrome, Salvador, Brazil.
Gouveia EL, Metcalfe J, de Carvalho AL, Aires TS, Villasboas-Bisneto JC, Queirroz A, Santos AC, Salgado K, Reis MG, Ko AI. Leptospirosis-associated severe pulmonary hemorrhagic syndrome, Salvador, Brazil. Emerging Infectious Diseases 2008, 14: 505-8. PMID: 18325275, PMCID: PMC2570821, DOI: 10.3201/eid1403.071064.
Global Morbidity and Mortality of Leptospirosis: A Systematic Review.
Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Neglected Tropical Diseases 2015, 9: e0003898. PMID: 26379143, PMCID: PMC4574773, DOI: 10.1371/journal.pntd.0003898.
Emergence of Congenital Zika Syndrome: Viewpoint From the Front Lines.
Costa F, Sarno M, Khouri R, de Paula Freitas B, Siqueira I, Ribeiro GS, Ribeiro HC, Campos GS, Alcântara LC, Reis MG, Weaver SC, Vasilakis N, Ko AI, Almeida AR. Emergence of Congenital Zika Syndrome: Viewpoint From the Front Lines. Annals Of Internal Medicine 2016, 164: 689-91. PMID: 26914810, PMCID: PMC5444536, DOI: 10.7326/M16-0332.
Cathelicidin Insufficiency in Patients with Fatal Leptospirosis.
Lindow JC, Wunder EA, Popper SJ, Min JN, Mannam P, Srivastava A, Yao Y, Hacker KP, Raddassi K, Lee PJ, Montgomery RR, Shaw AC, Hagan JE, Araújo GC, Nery N, Relman DA, Kim CC, Reis MG, Ko AI. Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. PLoS Pathogens 2016, 12: e1005943. PMID: 27812211, PMCID: PMC5094754, DOI: 10.1371/journal.ppat.1005943.
Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region.
Rodriguez-Barraquer I, Costa F, Nascimento EJM, Nery N, Castanha PMS, Sacramento GA, Cruz J, Carvalho M, De Olivera D, Hagan JE, Adhikarla H, Wunder EA, Coêlho DF, Azar SR, Rossi SL, Vasilakis N, Weaver SC, Ribeiro GS, Balmaseda A, Harris E, Nogueira ML, Reis MG, Marques ETA, Cummings DAT, Ko AI. Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. Science (New York, N.Y.) 2019, 363: 607-610. PMID: 30733412, PMCID: PMC8221194, DOI: 10.1126/science.aav6618.
Seroprevalence, Risk Factors, and Rodent Reservoirs of Leptospirosis in an Urban Community of Puerto Rico, 2015.
Briskin EA, Casanovas-Massana A, Ryff KR, Morales-Estrada S, Hamond C, Perez-Rodriguez NM, Benavidez KM, Weinberger DM, Castro-Arellano I, Wunder EA, Sharp TM, Rivera-Garcia B, Ko AI. Seroprevalence, Risk Factors, and Rodent Reservoirs of Leptospirosis in an Urban Community of Puerto Rico, 2015. The Journal Of Infectious Diseases 2019, 220: 1489-1497. PMID: 31342075, PMCID: PMC6761939, DOI: 10.1093/infdis/jiz339.
Risk of Zika microcephaly correlates with features of maternal antibodies.
Robbiani DF, Olsen PC, Costa F, Wang Q, Oliveira TY, Nery N, Aromolaran A, do Rosário MS, Sacramento GA, Cruz JS, Khouri R, Wunder EA, Mattos A, de Paula Freitas B, Sarno M, Archanjo G, Daltro D, Carvalho GBS, Pimentel K, de Siqueira IC, de Almeida JRM, Henriques DF, Lima JA, Vasconcelos PFC, Schaefer-Babajew D, Azzopardi SA, Bozzacco L, Gazumyan A, Belfort R, Alcântara AP, Carvalho G, Moreira L, Araujo K, Reis MG, Keesler RI, Coffey LL, Tisoncik-Go J, Gale M, Rajagopal L, Adams Waldorf KM, Dudley DM, Simmons HA, Mejia A, O'Connor DH, Steinbach RJ, Haese N, Smith J, Lewis A, Colgin L, Roberts V, Frias A, Kelleher M, Hirsch A, Streblow DN, Rice CM, MacDonald MR, de Almeida ARP, Van Rompay KKA, Ko AI, Nussenzweig MC. Risk of Zika microcephaly correlates with features of maternal antibodies. The Journal Of Experimental Medicine 2019, 216: 2302-2315. PMID: 31413072, PMCID: PMC6781003, DOI: 10.1084/jem.20191061.
Zika Virus Infection - After the Pandemic.
Musso D, Ko AI, Baud D. Zika Virus Infection - After the Pandemic. The New England Journal Of Medicine 2019, 381: 1444-1457. PMID: 31597021, DOI: 10.1056/NEJMra1808246.
An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete.
Gibson KH, Trajtenberg F, Wunder EA, Brady MR, San Martin F, Mechaly A, Shang Z, Liu J, Picardeau M, Ko A, Buschiazzo A, Sindelar CV. An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete. ELife 2020, 9 PMID: 32157997, PMCID: PMC7065911, DOI: 10.7554/eLife.53672.
Slum Health: Arresting COVID-19 and Improving Well-Being in Urban Informal Settlements.
Corburn J, Vlahov D, Mberu B, Riley L, Caiaffa WT, Rashid SF, Ko A, Patel S, Jukur S, Martínez-Herrera E, Jayasinghe S, Agarwal S, Nguendo-Yongsi B, Weru J, Ouma S, Edmundo K, Oni T, Ayad H. Slum Health: Arresting COVID-19 and Improving Well-Being in Urban Informal Settlements. Journal Of Urban Health : Bulletin Of The New York Academy Of Medicine 2020, 97: 348-357. PMID: 32333243, PMCID: PMC7182092, DOI: 10.1007/s11524-020-00438-6.
Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States.
Fauver JR, Petrone ME, Hodcroft EB, Shioda K, Ehrlich HY, Watts AG, Vogels CBF, Brito AF, Alpert T, Muyombwe A, Razeq J, Downing R, Cheemarla NR, Wyllie AL, Kalinich CC, Ott IM, Quick J, Loman NJ, Neugebauer KM, Greninger AL, Jerome KR, Roychoudhury P, Xie H, Shrestha L, Huang ML, Pitzer VE, Iwasaki A, Omer SB, Khan K, Bogoch II, Martinello RA, Foxman EF, Landry ML, Neher RA, Ko AI, Grubaugh ND. Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States. Cell 2020, 181: 990-996.e5. PMID: 32386545, PMCID: PMC7204677, DOI: 10.1016/j.cell.2020.04.021.
COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission.
Godri Pollitt KJ, Peccia J, Ko AI, Kaminski N, Dela Cruz CS, Nebert DW, Reichardt JKV, Thompson DC, Vasiliou V. COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission. Human Genomics 2020, 14: 17. PMID: 32398162, PMCID: PMC7214856, DOI: 10.1186/s40246-020-00267-3.
Coast-to-coast spread of SARS-CoV-2 in the United States revealed by genomic epidemiology.
Fauver JR, Petrone ME, Hodcroft EB, Shioda K, Ehrlich HY, Watts AG, Vogels CBF, Brito AF, Alpert T, Muyombwe A, Razeq J, Downing R, Cheemarla NR, Wyllie AL, Kalinich CC, Ott I, Quick J, Loman NJ, Neugebauer KM, Greninger AL, Jerome KR, Roychoundhury P, Xie H, Shrestha L, Huang ML, Pitzer VE, Iwasaki A, Omer SB, Khan K, Bogoch I, Martinello RA, Foxman EF, Landry ML, Neher RA, Ko AI, Grubaugh ND. Coast-to-coast spread of SARS-CoV-2 in the United States revealed by genomic epidemiology. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32511630, PMCID: PMC7276058, DOI: 10.1101/2020.03.25.20043828.
Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.
Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Barakat LA. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. BMC Neurology 2020, 20: 248. PMID: 32552792, PMCID: PMC7301053, DOI: 10.1186/s12883-020-01812-2.
Transmission of Chikungunya Virus in an Urban Slum, Brazil.
Anjos RO, Mugabe VA, Moreira PSS, Carvalho CX, Portilho MM, Khouri R, Sacramento GA, Nery NRR, Reis MG, Kitron UD, Ko AI, Costa F, Ribeiro GS. Transmission of Chikungunya Virus in an Urban Slum, Brazil. Emerging Infectious Diseases 2020, 26: 1364-1373. PMID: 32568045, PMCID: PMC7323528, DOI: 10.3201/eid2607.190846.
SARS-CoV-2 infection of the placenta.
Hosier H, Farhadian SF, Morotti RA, Deshmukh U, Lu-Culligan A, Campbell KH, Yasumoto Y, Vogels CB, Casanovas-Massana A, Vijayakumar P, Geng B, Odio CD, Fournier J, Brito AF, Fauver JR, Liu F, Alpert T, Tal R, Szigeti-Buck K, Perincheri S, Larsen C, Gariepy AM, Aguilar G, Fardelmann KL, Harigopal M, Taylor HS, Pettker CM, Wyllie AL, Dela Cruz CS, Ring AM, Grubaugh ND, Ko AI, Horvath TL, Iwasaki A, Reddy UM, Lipkind HS. SARS-CoV-2 infection of the placenta. The Journal Of Clinical Investigation 2020, 130: 4947-4953. PMID: 32573498, PMCID: PMC7456249, DOI: 10.1172/JCI139569.
Host response-based screening to identify undiagnosed cases of COVID-19 and expand testing capacity.
Cheemarla NR, Brito AF, Fauver JR, Alpert T, Vogels CBF, Omer SB, Ko A, Grubaugh ND, Landry ML, Foxman EF. Host response-based screening to identify undiagnosed cases of COVID-19 and expand testing capacity. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32577694, PMCID: PMC7302303, DOI: 10.1101/2020.06.04.20109306.
Sex differences in immune responses to SARS-CoV-2 that underlie disease outcomes.
Takahashi T, Wong P, Ellingson MK, Lucas C, Klein J, Israelow B, Silva J, Oh JE, Mao T, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, Sun J, Wang EY, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Casanovas-Massana A, Dela Cruz C, Fournier J, Odio CD, Farhadian S, Grubaugh N, Schulz WL, Ko A, Ring AM, Omer S, Iwasaki A. Sex differences in immune responses to SARS-CoV-2 that underlie disease outcomes. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32577695, PMCID: PMC7302304, DOI: 10.1101/2020.06.06.20123414.
Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT-qPCR primer-probe sets.
Vogels CBF, Brito AF, Wyllie AL, Fauver JR, Ott IM, Kalinich CC, Petrone ME, Casanovas-Massana A, Catherine Muenker M, Moore AJ, Klein J, Lu P, Lu-Culligan A, Jiang X, Kim DJ, Kudo E, Mao T, Moriyama M, Oh JE, Park A, Silva J, Song E, Takahashi T, Taura M, Tokuyama M, Venkataraman A, Weizman OE, Wong P, Yang Y, Cheemarla NR, White EB, Lapidus S, Earnest R, Geng B, Vijayakumar P, Odio C, Fournier J, Bermejo S, Farhadian S, Dela Cruz CS, Iwasaki A, Ko AI, Landry ML, Foxman EF, Grubaugh ND. Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT-qPCR primer-probe sets. Nature Microbiology 2020, 5: 1299-1305. PMID: 32651556, DOI: 10.1038/s41564-020-0761-6.
The Sensitivity of Respiratory Tract Specimens for the Detection of SARS-CoV-2: A Protocol for a Living Systematic Review and Meta-Analysis.
Moore AJ, Nakahata MI, Kalinich CC, Nyhan K, Bromberg DJ, Shi X, Ko AI, Grubaugh ND, Casanovas-Massana A, Wyllie AL. The Sensitivity of Respiratory Tract Specimens for the Detection of SARS-CoV-2: A Protocol for a Living Systematic Review and Meta-Analysis. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32637978, PMCID: PMC7340204, DOI: 10.1101/2020.07.02.20144543.
Severe leptospirosis after rat bite: A case report.
Faggion Vinholo T, Ribeiro GS, Silva NF, Cruz J, Reis MG, Ko AI, Costa F. Severe leptospirosis after rat bite: A case report. PLoS Neglected Tropical Diseases 2020, 14: e0008257. PMID: 32645040, PMCID: PMC7347098, DOI: 10.1371/journal.pntd.0008257.
Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators.
Schwarz B, Sharma L, Roberts L, Peng X, Bermejo S, Leighton I, Massana AC, Farhadian S, Ko A, DelaCruz C, Bosio CM. Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32676616, PMCID: PMC7359541, DOI: 10.1101/2020.07.09.20149849.
Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.
Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Cruz CD, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Aoun Barakat L. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. Research Square 2020 PMID: 32702723, PMCID: PMC7336693, DOI: 10.21203/rs.3.rs-28583/v1.
Longitudinal analyses reveal immunological misfiring in severe COVID-19.
Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, Ellingson MK, Mao T, Oh JE, Israelow B, Takahashi T, Tokuyama M, Lu P, Venkataraman A, Park A, Mohanty S, Wang H, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Muenker MC, Fournier JB, Campbell M, Odio CD, Casanovas-Massana A, Herbst R, Shaw AC, Medzhitov R, Schulz WL, Grubaugh ND, Dela Cruz C, Farhadian S, Ko AI, Omer SB, Iwasaki A. Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature 2020, 584: 463-469. PMID: 32717743, PMCID: PMC7477538, DOI: 10.1038/s41586-020-2588-y.
Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators.
Schwarz B, Sharma L, Roberts L, Peng X, Bermejo S, Leighton I, Massana AC, Farhadian S, Ko AI, Cruz CSD, Bosio CM. Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators. Research Square 2020 PMID: 32743565, PMCID: PMC7386513, DOI: 10.21203/rs.3.rs-42999/v1.
Clinical Characteristics and Outcomes for 7,995 Patients with SARS-CoV-2 Infection.
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJ, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical Characteristics and Outcomes for 7,995 Patients with SARS-CoV-2 Infection. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32743602, PMCID: PMC7386526, DOI: 10.1101/2020.07.19.20157305.
Feasibility and acceptability of a pilot, peer-led HIV self-testing intervention in a hyperendemic fishing community in rural Uganda.
Matovu JKB, Bogart LM, Nakabugo J, Kagaayi J, Serwadda D, Wanyenze RK, Ko AI, Kurth AE. Feasibility and acceptability of a pilot, peer-led HIV self-testing intervention in a hyperendemic fishing community in rural Uganda. PloS One 2020, 15: e0236141. PMID: 32764751, PMCID: PMC7413506, DOI: 10.1371/journal.pone.0236141.
Simply saliva: stability of SARS-CoV-2 detection negates the need for expensive collection devices.
Ott IM, Strine MS, Watkins AE, Boot M, Kalinich CC, Harden CA, Vogels CBF, Casanovas-Massana A, Moore AJ, Muenker MC, Nakahata M, Tokuyama M, Nelson A, Fournier J, Bermejo S, Campbell M, Datta R, Dela Cruz CS, Farhadian SF, Ko AI, Iwasaki A, Grubaugh ND, Wilen CB, Wyllie AL. Simply saliva: stability of SARS-CoV-2 detection negates the need for expensive collection devices. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32793924, PMCID: PMC7418742, DOI: 10.1101/2020.08.03.20165233.
Anicteric Leptospirosis-Associated Meningitis in a Tropical Urban Environment, Brazil.
Nabity SA, Araújo GC, Hagan JE, Damião AO, Reis MG, Ko AI, Ribeiro GS. Anicteric Leptospirosis-Associated Meningitis in a Tropical Urban Environment, Brazil. Emerging Infectious Diseases 2020, 26: 2190-2192. PMID: 32818405, PMCID: PMC7454101, DOI: 10.3201/eid2609.191001.
Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2.
Wyllie AL, Fournier J, Casanovas-Massana A, Campbell M, Tokuyama M, Vijayakumar P, Warren JL, Geng B, Muenker MC, Moore AJ, Vogels CBF, Petrone ME, Ott IM, Lu P, Venkataraman A, Lu-Culligan A, Klein J, Earnest R, Simonov M, Datta R, Handoko R, Naushad N, Sewanan LR, Valdez J, White EB, Lapidus S, Kalinich CC, Jiang X, Kim DJ, Kudo E, Linehan M, Mao T, Moriyama M, Oh JE, Park A, Silva J, Song E, Takahashi T, Taura M, Weizman OE, Wong P, Yang Y, Bermejo S, Odio CD, Omer SB, Dela Cruz CS, Farhadian S, Martinello RA, Iwasaki A, Grubaugh ND, Ko AI. Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2. The New England Journal Of Medicine 2020, 383: 1283-1286. PMID: 32857487, PMCID: PMC7484747, DOI: 10.1056/NEJMc2016359.
Sex differences in immune responses that underlie COVID-19 disease outcomes.
Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, Silva J, Mao T, Oh JE, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, Sun J, Wang EY, Casanovas-Massana A, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Shaw A, Fournier JB, Odio CD, Farhadian S, Dela Cruz C, Grubaugh ND, Schulz WL, Ring AM, Ko AI, Omer SB, Iwasaki A. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature 2020, 588: 315-320. PMID: 32846427, PMCID: PMC7725931, DOI: 10.1038/s41586-020-2700-3.
Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.
Holzapfel M, Bonhomme D, Cagliero J, Vernel-Pauillac F, Fanton d'Andon M, Bortolussi S, Fiette L, Goarant C, Wunder EA, Picardeau M, Ko AI, Werling D, Matsui M, Boneca IG, Werts C. Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella. Frontiers In Immunology 2020, 11: 2007. PMID: 32849665, PMCID: PMC7431986, DOI: 10.3389/fimmu.2020.02007.
A multivariate geostatistical framework for combining multiple indices of abundance for disease vectors and reservoirs: a case study of rattiness in a low-income urban Brazilian community.
Eyre MT, Carvalho-Pereira TSA, Souza FN, Khalil H, Hacker KP, Serrano S, Taylor JP, Reis MG, Ko AI, Begon M, Diggle PJ, Costa F, Giorgi E. A multivariate geostatistical framework for combining multiple indices of abundance for disease vectors and reservoirs: a case study of rattiness in a low-income urban Brazilian community. Journal Of The Royal Society, Interface / The Royal Society 2020, 17: 20200398. PMID: 32871096, PMCID: PMC7536052, DOI: 10.1098/rsif.2020.0398.
Pooling saliva to increase SARS-CoV-2 testing capacity.
Watkins AE, Fenichel EP, Weinberger DM, Vogels CBF, Brackney DE, Casanovas-Massana A, Campbell M, Fournier J, Bermejo S, Datta R, Dela Cruz CS, Farhadian SF, Iwasaki A, Ko AI, Grubaugh ND, Wyllie AL. Pooling saliva to increase SARS-CoV-2 testing capacity. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32909003, PMCID: PMC7480055, DOI: 10.1101/2020.09.02.20183830.
Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement.
Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander J, Gallego JA, Lencz T, Walsh H, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement. BioRxiv : The Preprint Server For Biology 2020 PMID: 32935102, PMCID: PMC7491516, DOI: 10.1101/2020.09.11.293464.
Kynurenic acid underlies sex-specific immune responses to COVID-19.
Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker CM, Silva J, Wong P, Ko AJ, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid underlies sex-specific immune responses to COVID-19. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32935119, PMCID: PMC7491534, DOI: 10.1101/2020.09.06.20189159.
Tracking Smell Loss to Identify Healthcare Workers with SARS-CoV-2 Infection.
Weiss JJ, Attuquayefio TN, White EB, Li F, Herz RS, White TL, Campbell M, Geng B, Datta R, Wyllie AL, Grubaugh ND, Casanovas-Massana A, Muenker MC, Handoko R, Iwasaki A, Martinello RA, Ko AI, Small DM, Farhadian SF. Tracking Smell Loss to Identify Healthcare Workers with SARS-CoV-2 Infection. MedRxiv : The Preprint Server For Health Sciences 2020 PMID: 32935121, PMCID: PMC7491536, DOI: 10.1101/2020.09.07.20188813.
Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics.
Peccia J, Zulli A, Brackney DE, Grubaugh ND, Kaplan EH, Casanovas-Massana A, Ko AI, Malik AA, Wang D, Wang M, Warren JL, Weinberger DM, Arnold W, Omer SB. Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics. Nature Biotechnology 2020, 38: 1164-1167. PMID: 32948856, PMCID: PMC8325066, DOI: 10.1038/s41587-020-0684-z.
Seroepidemiology of Leptospira infection in slaughtered cattle in Gauteng province, South Africa.
Dogonyaro BB, van Heerden H, Potts AD, Kolo BF, Lotter C, Katsande C, Fasina FO, Ko AI, Wunder EA, Adesiyun AA. Seroepidemiology of Leptospira infection in slaughtered cattle in Gauteng province, South Africa. Tropical Animal Health And Production 2020, 52: 3789-3798. PMID: 33009586, DOI: 10.1007/s11250-020-02417-0.
Detection of SARS-CoV-2 RNA by multiplex RT-qPCR.
Kudo E, Israelow B, Vogels CBF, Lu P, Wyllie AL, Tokuyama M, Venkataraman A, Brackney DE, Ott IM, Petrone ME, Earnest R, Lapidus S, Muenker MC, Moore AJ, Casanovas-Massana A, Omer SB, Dela Cruz CS, Farhadian SF, Ko AI, Grubaugh ND, Iwasaki A. Detection of SARS-CoV-2 RNA by multiplex RT-qPCR. PLoS Biology 2020, 18: e3000867. PMID: 33027248, PMCID: PMC7571696, DOI: 10.1371/journal.pbio.3000867.
Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study.
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Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators.
Schwarz B, Sharma L, Roberts L, Peng X, Bermejo S, Leighton I, Casanovas-Massana A, Minasyan M, Farhadian S, Ko AI, Dela Cruz CS, Bosio CM. Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators. Journal Of Immunology (Baltimore, Md. : 1950) 2021, 206: 329-334. PMID: 33277388, PMCID: PMC7962598, DOI: 10.4049/jimmunol.2001025.
Effects of Accounting for Interval-Censored Antibody Titer Decay on Seroincidence in a Longitudinal Cohort Study of Leptospirosis.
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Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver.
Waxman DJ, Ko A, Walsh C. Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver. The Journal Of Biological Chemistry 1983, 258: 11937-47. PMID: 6619150.
Diverse Functional Autoantibodies in Patients with COVID-19.
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Kinetics of antibody responses dictate COVID-19 outcome.
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Risk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents.
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Saliva viral load is a dynamic unifying correlate of COVID-19 severity and mortality.
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A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus.
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SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity.
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SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface.
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Knowledge, Attitude, and Practices regarding Leptospirosis among Visitors to a Recreational Forest in Malaysia.
Shafie NJ, Abdul Halim NS, Nor Zalipah M, Mohd Amin NAZ, Syed Esa SM, Md-Nor S, Casanovas-Massana A, Ko AI, Palma F, Neves Souza F, Costa F. Knowledge, Attitude, and Practices regarding Leptospirosis among Visitors to a Recreational Forest in Malaysia. The American Journal Of Tropical Medicine And Hygiene 2021 PMID: 33534768, PMCID: PMC8045624, DOI: 10.4269/ajtmh.20-0306.
Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study.
Aguilar Ticona JP, Nery N, Ladines-Lim JB, Gambrah C, Sacramento G, de Paula Freitas B, Bouzon J, Oliveira-Filho J, Borja A, Adhikarla H, Montoya M, Chin A, Wunder EA, Ballalai V, Vieira C, Belfort R, P Almeida AR, Reis MG, Harris E, Ko AI, Costa F. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLoS Neglected Tropical Diseases 2021, 15: e0009162. PMID: 33544730, PMCID: PMC7891708, DOI: 10.1371/journal.pntd.0009162.
Correction to: Slum Health: Arresting COVID-19 and Improving Well-Being in Urban Informal Settlements.
Corburn J, Vlahov D, Mberu B, Riley L, Caiaffa WT, Rashid SF, Ko A, Patel S, Jukur S, Martínez-Herrera E, Jayasinghe S, Agarwal S, Nguendo-Yongsi B, Weru J, Ouma S, Edmundo K, Oni T, Ayad H. Correction to: Slum Health: Arresting COVID-19 and Improving Well-Being in Urban Informal Settlements. Journal Of Urban Health : Bulletin Of The New York Academy Of Medicine 2021, 98: 309-310. PMID: 33570740, PMCID: PMC7877315, DOI: 10.1007/s11524-020-00491-1.
SARS-CoV-2 Infection Hospitalization Rate and Infection Fatality Rate Among the Non-Congregate Population in Connecticut.
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Tracking smell loss to identify healthcare workers with SARS-CoV-2 infection.
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Household rat infestation in urban slum populations: Development and validation of a predictive score for leptospirosis.
Costa F, Zeppelini CG, Ribeiro GS, Santos N, Reis RB, Martins RD, Bittencourt D, Santana C, Brant J, Reis MG, Ko AI. Household rat infestation in urban slum populations: Development and validation of a predictive score for leptospirosis. PLoS Neglected Tropical Diseases 2021, 15: e0009154. PMID: 33657101, PMCID: PMC7959339, DOI: 10.1371/journal.pntd.0009154.
Stability of SARS-CoV-2 RNA in Nonsupplemented Saliva.
Ott IM, Strine MS, Watkins AE, Boot M, Kalinich CC, Harden CA, Vogels CBF, Casanovas-Massana A, Moore AJ, Muenker MC, Nakahata M, Tokuyama M, Nelson A, Fournier J, Bermejo S, Campbell M, Datta R, Dela Cruz CS, Farhadian SF, Ko AI, Iwasaki A, Grubaugh ND, Wilen CB, Wyllie AL. Stability of SARS-CoV-2 RNA in Nonsupplemented Saliva. Emerging Infectious Diseases 2021, 27: 1146-1150. PMID: 33754989, PMCID: PMC8007305, DOI: 10.3201/eid2704.204199.
Increased SARS-CoV-2 Testing Capacity with Pooled Saliva Samples.
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Incidence and prevalence of tuberculosis in incarcerated populations: a systematic review and meta-analysis.
Cords O, Martinez L, Warren JL, O'Marr JM, Walter KS, Cohen T, Zheng J, Ko AI, Croda J, Andrews JR. Incidence and prevalence of tuberculosis in incarcerated populations: a systematic review and meta-analysis. The Lancet. Public Health 2021, 6: e300-e308. PMID: 33765455, PMCID: PMC8168455, DOI: 10.1016/S2468-2667(21)00025-6.
Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection.
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PloS One 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.
Poverty, sanitation, and Leptospira transmission pathways in residents from four Brazilian slums.
Khalil H, Santana R, de Oliveira D, Palma F, Lustosa R, Eyre MT, Carvalho-Pereira T, Reis MG, Ko AI, Diggle PJ, Alzate Lopez Y, Begon M, Costa F. Poverty, sanitation, and Leptospira transmission pathways in residents from four Brazilian slums. PLoS Neglected Tropical Diseases 2021, 15: e0009256. PMID: 33788864, PMCID: PMC8041187, DOI: 10.1371/journal.pntd.0009256.
Case Study: Longitudinal immune profiling of a SARS-CoV-2 reinfection in a solid organ transplant recipient.
Klein J, Brito AF, Trubin P, Lu P, Wong P, Alpert T, Peña-Hernández MA, Haynes W, Kamath K, Liu F, Vogels CBF, Fauver JR, Lucas C, Oh J, Mao T, Silva J, Wyllie AL, Muenker MC, Casanovas-Massana A, Moore AJ, Petrone ME, Kalinich CC, Cruz CD, Farhadian S, Ring A, Shon J, Ko AI, Grubaugh ND, Israelow B, Iwasaki A, Azar MM. Case Study: Longitudinal immune profiling of a SARS-CoV-2 reinfection in a solid organ transplant recipient. MedRxiv : The Preprint Server For Health Sciences 2021 PMID: 33791729, PMCID: PMC8010761, DOI: 10.1101/2021.03.24.21253992.
The escalating tuberculosis crisis in central and South American prisons.
Walter KS, Martinez L, Arakaki-Sanchez D, Sequera VG, Estigarribia Sanabria G, Cohen T, Ko AI, García-Basteiro AL, Rueda ZV, López-Olarte RA, Espinal MA, Croda J, Andrews JR. The escalating tuberculosis crisis in central and South American prisons. Lancet 2021, 397: 1591-1596. PMID: 33838724, DOI: 10.1016/S0140-6736(20)32578-2.
Angiostrongylus cantonensis in urban populations of terrestrial gastropods and rats in an impoverished region of Brazil.
Souza FN, Aguiar Santos M, Alves DA, Melo LCV, Mota DJGD, Pertile AC, Gava R, Pinto PLS, Eyre MT, Zeppelini CG, Reis MGD, Ko AI, Begon M, Bahiense TC, Costa F, Carvalho-Pereira TSA. Angiostrongylus cantonensis in urban populations of terrestrial gastropods and rats in an impoverished region of Brazil. Parasitology 2021, 148: 994-1002. PMID: 33843507, DOI: 10.1017/S0031182021000597.
Delayed production of neutralizing antibodies correlates with fatal COVID-19.
Lucas C, Klein J, Sundaram ME, Liu F, Wong P, Silva J, Mao T, Oh JE, Mohanty S, Huang J, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Vogels CBF, Muenker MC, Chang CH, Casanovas-Massana A, Moore AJ, Zell J, Fournier JB, Wyllie AL, Campbell M, Lee A, Chun HJ, Grubaugh ND, Schulz WL, Farhadian S, Dela Cruz C, Ring AM, Shaw AC, Wisnewski AV, Yildirim I, Ko AI, Omer S, Iwasaki A. Delayed production of neutralizing antibodies correlates with fatal COVID-19. Nature Medicine 2021, 27: 1178-1186. PMID: 33953384, DOI: 10.1038/s41591-021-01355-0.
Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms.
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Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface.
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Diverse functional autoantibodies in patients with COVID-19.
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Longitudinal immune profiling of a SARS-CoV-2 reinfection in a solid organ transplant recipient.
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Accuracy of Computable Phenotyping Approaches for SARS-CoV-2 Infection and COVID-19 Hospitalizations from the Electronic Health Record.
Khera R, Mortazavi BJ, Sangha V, Warner F, Young HP, Ross JS, Shah ND, Theel ES, Jenkinson WG, Knepper C, Wang K, Peaper D, Martinello RA, Brandt CA, Lin Z, Ko AI, Krumholz HM, Pollock BD, Schulz WL. Accuracy of Computable Phenotyping Approaches for SARS-CoV-2 Infection and COVID-19 Hospitalizations from the Electronic Health Record. MedRxiv : The Preprint Server For Health Sciences 2021 PMID: 34013299, PMCID: PMC8132274, DOI: 10.1101/2021.03.16.21253770.
Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein.
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Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19.
Lucas C, Klein J, Sundaram ME, Liu F, Wong P, Silva J, Mao T, Oh JE, Mohanty S, Huang J, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Vogels CBF, Muenker MC, Chang CH, Casanovas-Massana A, Moore AJ, Zell J, Fournier JB, Wyllie AL, Campbell M, Lee AI, Chun HJ, Grubaugh ND, Schulz WL, Farhadian S, Dela Cruz C, Ring AM, Shaw AC, Wisnewski AV, Yildirim I, Ko AI, Omer SB, Iwasaki A. Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19. Nature Medicine 2021, 27: 1309. PMID: 34145437, PMCID: PMC8212078, DOI: 10.1038/s41591-021-01416-4.
Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis.
Casanovas-Massana A, de Oliveira D, Schneider AG, Begon M, Childs JE, Costa F, Reis MG, Ko AI, Wunder EA. Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis. The Journal Of Infectious Diseases 2022, 225: 130-134. PMID: 34139761, PMCID: PMC8730487, DOI: 10.1093/infdis/jiab323.
Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2.
Zhao M, Su PY, Castro DA, Tripler TN, Hu Y, Cook M, Ko AI, Farhadian SF, Israelow B, Dela Cruz CS, Xiong Y, Sutton RE. Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2. PLoS Pathogens 2021, 17: e1009683. PMID: 34166473, PMCID: PMC8263067, DOI: 10.1371/journal.ppat.1009683.
Kynurenic acid may underlie sex-specific immune responses to COVID-19.
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Maternal outcomes and risk factors for COVID-19 severity among pregnant women.
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Social determinants associated with Zika virus infection in pregnant women.
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Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study.
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Reply to: A finding of sex similarities rather than differences in COVID-19 outcomes.
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Willingness to Get the COVID-19 Vaccine among Residents of Slum Settlements.
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Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity.
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Longitudinal immune profiling of a SARS-CoV-2 reinfection in a solid organ transplant recipient.
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High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19.
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Effect of Sewerage on the Contamination of Soil with Pathogenic Leptospira in Urban Slums.
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De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: A case report.
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